JP2015203006A - oral composition and bad breath inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition and a bad breath inhibitor in which the effects of inhibiting bad breath derived from lower fatty acids, such as isovaleric acid, are improved and which have excellent bad breath inhibiting effects.SOLUTION: The invention provides an oral composition containing extract (A) from Lindera umbellata Thunb. containing 3,5-dihydroxy-2-menthenyl stilbene or 3,5-dihydroxystilbene, or subspecies thereof, and an anti-inflammatory agent (B); and a bad breath inhibitor comprising the components (A) and (B).

Description

  The present invention relates to a composition for oral cavity containing an extract from kuromoji or a subspecies thereof, which has an improved effect of suppressing bad breath derived from lower fatty acids such as isovaleric acid and is excellent in bad breath, and a bad breath suppressant. .

  In recent years, awareness of bad breath has gradually increased. As major halitosis-causing substances, volatile sulfur compounds (VSC) such as methyl mercaptan and hydrogen sulfide and lower fatty acids such as isovaleric acid are known.

  As for the present breath odor suppressant, various techniques such as deodorization, metabolic inhibition, and antibacterial have been proposed focusing on the application of natural products. However, most of them are directed to volatile sulfur compounds (VSC) such as methyl mercaptan and their producing bacteria. Specifically, a deodorant (Patent Document 1; Japanese Patent Laid-Open No. 63-309269) using a plant extract and an oxidoreductase in combination or a specific plant extract and an enzyme that oxidizes a phenolic compound are used in combination. Deodorant (Patent Document 2; JP-A-10-212221, Patent Document 3; JP-A 2010-158375), deodorant using a plurality of specific plant extracts (Patent Document 4; JP 2013-2013) -103905).

  On the other hand, there are almost no reports of halitosis control technology regarding lower fatty acids. Since lower fatty acids such as isovaleric acid have a strong malodor even in a small amount, not only volatile sulfur compounds (VSC) but also bad breath derived from lower fatty acids can be effective in suppressing bad breath.

JP-A 63-309269 JP 10-212221 A JP 2010-158375 A JP 2013-103905 A Japanese Unexamined Patent Publication No. 2011-148783 JP 2013-1701 A

  Accordingly, it is desired to develop a bad breath suppression technology applying natural products that can strongly suppress bad breath derived from lower fatty acids such as isovaleric acid.

  The present invention has been made in view of the above circumstances, and has an object to provide a composition for oral cavity and a mouth odor inhibitor that are particularly effective in suppressing bad breath derived from lower fatty acids such as isovaleric acid and that are excellent in bad breath suppression effect. And

  As a result of intensive studies to achieve the above object, the present inventors have found that an extract from 3,5-dihydroxy-2-mentenylstilbene or chromodi containing 3,5-dihydroxystilbene or a subspecies thereof ( By combining A) and the anti-inflammatory agent (B), in particular, the effect of suppressing bad breath derived from lower fatty acids such as isovaleric acid is remarkably increased, and the effect of suppressing bad breath is excellent, these (A), ( By blending the combination system of the component B) into the oral composition, it is possible to apply a substance derived from natural products to give a remarkably excellent bad breath suppression effect, and to suppress discoloration and to improve the appearance of the preparation over time. The inventors have found that it can be maintained stably, and have reached the present invention.

  The applicant has disclosed that an extract of 3,5-dihydroxy-2-mentenylstilbene, 3,5-dihydroxystilbene, chromodi containing it, or a subspecies thereof has antimicrobial activity, malodor production inhibiting activity, It is effective as an agent and odor production inhibitor, and can be applied to a composition for oral cavity (Patent Document 5; JP-A-2011-148783), a combination of the above components and an extract containing this and a bactericidal antibacterial agent The antimicrobial agent was proposed to be applicable to oral compositions (Patent Document 6; Japanese Patent Application Laid-Open No. 2013-1701), but there was room for improvement because it was difficult to suppress bad breath. Then, as a result of further investigation, the present inventors combined 3,5-dihydroxy-2-mentenylstilbene or an extract (A) containing 3,5-dihydroxystilbene with an anti-inflammatory agent (B). In addition, the bad breath suppression effect is remarkably enhanced over the combination of component (A), and the amount of isovaleric acid can be suppressed by 50% or more even when the oral cleaning is stopped for 3 days, as shown in the experimental examples described later. A bad breath suppressing effect can be imparted, and appearance stability that can suppress the discoloration of the preparation even when stored at 60 ° C. for 1 month can be imparted.

Accordingly, the present invention provides the following oral composition and halitosis inhibitor.
[1]
3. An extract (A) from 3,5-dihydroxy-2-mentenylstilbene or chromodi containing 3,5-dihydroxystilbene or a subspecies thereof, and an anti-inflammatory agent (B) An oral composition.
[2]
(A) In the extract [1], the component contains 3,5-dihydroxy-2-mentenylstilbene in an amount of 1% by mass or more of solids or 3,5-dihydroxystilbene in an amount of 1% by mass or more of solids The composition for oral cavity of description.
[3]
(B) The composition for oral cavity as described in [1] or [2] whose component is (epsilon) -aminocaproic acid and / or tranexamic acid.
[4]
The content of the component (A) is 0.0001 to 3.1% by mass in terms of the pure content of 3,5-dihydroxy-2-mentenylstilbene or 3,5-dihydroxystilbene, and the content of the component (B) is Oral composition as described in [1], [2] or [3] which is 0.002-1 mass%.
[5]
The blending ratio of the component (A) and the component (B) is as described in any one of [1] to [4], in which (A) :( B) is 100: 1 to 1: 1,000 as a mass ratio. Oral composition.
[6]
The composition for oral cavity according to any one of [1] to [5], which is a mouthwash or a dentifrice.
[7]
A halitosis inhibitor comprising an extract (A) from 3,5-dihydroxy-2-mentenylstilbene or chromodi containing 3,5-dihydroxystilbene or a subspecies thereof, and an anti-inflammatory agent (B).
[8]
[7] The component (A) is an extract containing 3,5-dihydroxy-2-mentenylstilbene in an amount of 1% by mass or more of solids or 3,5-dihydroxystilbene in an amount of 1% by mass or more of solids. The bad breath suppressant described.
[9]
The malodor control agent according to [7] or [8], wherein the blending ratio of component (A) to component (B) is (A) :( B) from 100: 1 to 1: 1,000 as a mass ratio. .

  According to the present invention, in particular, the oral odor control effect derived from lower fatty acids such as isovaleric acid is remarkably improved, the oral odor control effect is excellent, the discoloration of the preparation is suppressed, and the appearance stability is good, and A bad breath suppressant can be provided.

  The present invention will be described in further detail below. In the present invention, 3,5-dihydroxy-2-mentenylstilbene or an extract (A) from chromodi or 3,5 dihydroxystilbene-containing subspecies and an anti-inflammatory agent (B) are used in combination. It is characterized by.

  The extract from component (A) chromodi or its subspecies contains 3,5-dihydroxy-2-mentenylstilbene and / or 3,5-dihydroxystilbene, preferably 3,5-dihydroxy-2- Mentenyl stilbene is contained in an amount of 1% by mass or more of solids, and 3,5-dihydroxystilbene is contained in an amount of 1% by mass or more of solids.

  3,5-dihydroxy-2-mentenylstilbene and 3,5-dihydroxystilbene are represented by the following structural formulas (1) and (2), respectively, and are genus Kuromoji, in particular, Kurodoji (LINDERA UMBELLATA) or its It is an active ingredient that can be obtained by solvent extraction from the subspecies. These active ingredients can be used as they are, but in the present invention, an extract of the genus Cromodium which contains the active ingredient in a high concentration is used. As an extract of the plant of the genus Cromodium containing an active ingredient at a high concentration, the contents of 3,5-dihydroxy-2-mentenylstilbene and 3,5-dihydroxystilbene, which are active ingredients, are each 1% by mass of the solid content. Above all, in particular, an extract from black moji or its subspecies that is 3 mass% or more is preferable.

Here, the plant of the genus Kuromoji can use the whole plant as a raw material, but a part thereof (branches, trunks, roots, buds, leaves, flowers, fruits, etc.) can also be used. In particular, it is preferable to use branches, trunks, and roots from the viewpoint of the yield of the target compound. Further, the origin plant may be any plant belonging to the genus Chromoji. Specific examples are: Okinawa leaf varieties (Lindera communis var. Okinawensis), Japanese cypress (Lindera erythrocarpa), Japanese horn beetle (Lindra glauca), L. , Usuda kuromoji (Lindera umbellata var. Aurantia var. Aurantia var. Aurantia var. Aurantia var. umbellata var. lancea), psyllium var. membranacea, linde prax. It is possible to suitably use white moji (Lindera triloba), mareboshi moji (Parabenzoin trilobum f. Integurum), keboshi moji (Parabenzoin trilobum f. aumbellata) and its subspecies can be used from Lindera umbellata var. aurantica, Lindera umbellata var. lancea, and P. umbellata var. membra.
These genus Cromodium genus plants are preferably in a dry state, but can be used even in a wet state.

Extraction from genus Chromomo is one kind of lower alcohol, polyhydric alcohols such as glycerin and propylene glycol, saturated hydrocarbons such as pentane, hexane and heptane, ethyl acetate, acetone, petroleum ether, acidic solution and alkaline solution. Can be used alone or in combination of two or more. Among these, it can extract efficiently with an organic solvent, and especially the hydrophilic organic solvent is excellent from the viewpoint of extraction efficiency. In particular, a lower alcohol having 1 to 4 carbon atoms, that is, methanol, ethanol, propanol, isopropanol, n-butanol, isobutanol, t-butanol, or a mixture thereof can be used more preferably. Further, these water-soluble organic solvents are more preferably water-containing organic solvents, and most preferably, extraction with a water-containing alcohol having a concentration of 30 to 95% by mass can extract the target component more efficiently.
These extraction solvents are preferably used in a mass ratio of about 1 to 50 times, particularly preferably 2 to 20 times, with respect to the extraction raw material.

  From the extract, solids are removed by filtration, centrifugation, and the like, and after concentration, a crude extract fraction can be obtained. Since this crude extract fraction also contains the active substances 3,5-dihydroxy-2-mentenylstilbene and 3,5-dihydroxystilbene, the crude extract fraction can be added to the composition as it is. Although it is good, from the viewpoint of ensuring the stability of the composition, it is preferable to use one that has been further fractionated and purified.

  In this case, fractionation and purification can be performed by combining partition extraction with a solvent and various types of chromatography. In consideration of the molecular weight and physicochemical properties of the target substance, the conditions for the carrier and the elution solvent can be appropriately selected from methods corresponding to various chromatographies.

Moreover, as the second method, a supercritical extraction method by contacting with carbon dioxide in a supercritical state can be suitably employed. In this case, the pulverized product of the genus Cromodium is extracted using a mixture of carbon dioxide in a supercritical state and an aqueous solution of 2 to 10% by mass of ethanol, and the soluble part thereof is collected to obtain an active ingredient of the genus Cromodium. Can also be collected.
Furthermore, a black-skinned plant is extracted with 40 to 100% by mass, preferably 60 to 90% by mass ethanol aqueous solution, and the extract is used as a mixture of carbon dioxide in a supercritical state and 2 to 10% by mass ethanol aqueous solution. It is also possible to extract the extract and extract the extract to collect the active ingredients of the genus Cromodium.
By performing such a supercritical extraction step, usually a mixture of 3,5-dihydroxy-2-mentenylstilbene and 3,5-dihydroxystilbene is obtained, but by appropriately adjusting the extraction conditions, 3,5-Dihydroxy-2-mentenylstilbene or 3,5-dihydroxystilbene can also be obtained alone. If necessary, 3,5-dihydroxy-2-mentenylstilbene or 3,5-dihydroxystilbene can be isolated from the obtained mixture.

  By performing such a step, 3,5-dihydroxy-2-mentenylstilbene and 3,5-dihydroxystilbene are respectively 1% by mass or more, particularly 3% by mass or more, especially 5% by mass of the extract solids. What contains 20 mass% or less can be prepared, and this can be used as an extract from the black moji which contains the active ingredient of Formula (1) and Formula (2) in high concentration, or its subspecies.

  In addition, as the anti-inflammatory agent of component (B), ε-aminocaproic acid, tranexamic acid, β-glycyrrhetinic acid, glycyrrhizic acid, glycyrrhizic acid dipotassium glycyrrhizic acid or salts thereof, dihydrocholesterol, allantoin, allantoindihydroxyaluminum, etc. Examples include allantoin or a derivative thereof, azulene sulfonate such as a buckwheat extract, sodium azulenesulfonate, and the like, and one of these may be used alone or in combination of two or more. Among these, ε-aminocaproic acid, tranexamic acid, β-glycyrrhetinic acid, glycyrrhizic acid or a salt thereof, and a buckwheat extract are preferable, and ε-aminocaproic acid and tranexamic acid are more preferable.

A commercial item can be used for an anti-inflammatory agent. Specifically, the following can be used.
ε-aminocaproic acid; Tranexamic acid manufactured by Daiichi Sankyo Co., Ltd. (Japanese Pharmacopoeia compatible product); β-glycyrrhetinic acid manufactured by Simic CMO Co .; dipotassium glycyrrhizinate manufactured by Alps Pharmaceutical Industries, Ltd .; Allantoin manufactured by Nippon Seika Co., Ltd .; Awaku extract manufactured by ISP Japan Co., Ltd. (water-dried extract, berberine content 5.0 mass%); sodium azulene sulfonate manufactured by Ogi Pharmaceutical Co., Ltd .; manufactured by Alps Pharmaceutical Co., Ltd.

In the present invention, an extract (A) from the above black moji or a subspecies thereof, and an anti-inflammatory agent (B) are combined, and this is blended in the oral composition as a bad breath suppressant.
In this case, the blending amount of the component (A) extract from chromodi or its subspecies is converted to 3,5-dihydroxy-2-mentenylstilbene, and further to 3,5-dihydroxystilbene (pure component conversion). ) Can be determined.
The amount of component (A) is 3,05-dihydroxy-2-mentenylstilbene and 3,5-dihydroxystilbene, and the total amount is 0.0001-3.1% by mass of the total composition. More preferably, it is 0.003-3.1 mass%, Most preferably, it is 0.003-1.6 mass%. When the blending amount is 0.0001% by mass or more, the bad breath suppressing effect is sufficiently exhibited, and when the blending amount is 3.1% by mass or less, the feeling of use and usability of the composition are maintained well, and the taste, smell, etc. It is suitable for suppressing the uncomfortable feeling and the poor dissolution.
In addition, it is preferable that the amount of 3, 5- dihydroxy-2- mentenyl stilbene is 0.0001-3 mass% of the whole composition, More preferably, it is 0.0005-1 mass%. The amount of 3,5-dihydroxystilbene is preferably 0.0001 to 2% by mass, more preferably 0.001 to 1% by mass, based on the entire composition.

  Furthermore, when using a chromodi extract that has been subjected to fractionation purification using 3,5-dihydroxy-2-mentenylstilbene or 3,5-dihydroxystilbene as an active ingredient, impurities in the extract can be incorporated into the composition at a high concentration. May cause problems such as coloring and discoloration. If the concentration is too low, it may be difficult to suppress discoloration. In this case, the blending amount of the chromomy extract that is the extract of the component (A) is preferably 10% by mass or less, more preferably less than 10% by mass of the entire composition from the viewpoint of preventing discoloration, more preferably 5% by mass. It is as follows. Moreover, it is preferable that it is 0.001 mass% or more, More preferably, it is 0.01 mass% or more. When 0.001 mass% or more is mix | blended, the sufficient bad breath suppression effect can be provided and discoloration can also be suppressed. When the amount is 10% by mass or less, the discoloration of the preparation can be sufficiently suppressed.

  Further, the blending amount of the anti-inflammatory agent as the component (B) is preferably 0.002 to 1% by mass, more preferably 0.005 to 1% by mass, and particularly preferably 0.005 to 0.5% of the entire composition. % By mass. When 0.002 mass% or more is blended, the bad breath suppressing effect is sufficiently improved, and when it is 1 mass% or less, discoloration can be sufficiently suppressed, which is preferable.

Furthermore, the anti-inflammatory agent of (B) component can be used in the compounding amount suitable for each anti-inflammatory agent in the range of the said compounding quantity individually by 1 type or in combination of 2 or more types.
The amount of ε-aminocaproic acid, tranexamic acid, β-glycyrrhetinic acid, glycyrrhizic acid or a salt thereof (blending amount as glycyrrhizic acid), dihydrocholesterol, allantoin or a derivative thereof (blending amount as allantoin) 0.002 to 1.0 mass% is preferable, and 0.005 to 0.5 mass% is particularly preferable.
0.005 to 0.5 mass% is preferable as the compounding amount of the buckwheat extract, and it is preferable that the content of berberine is 0.0003 to 0.03 mass% with respect to the total amount of the composition in terms of solid content. In particular, it is more preferable that the compounding amount of the buckwheat extract is 0.02 to 0.2% by mass, and the content of berberine is 0.0012 to 0.012% by mass in terms of solid content.
The blending amount of azulene sulfonate is preferably 0.0002 to 0.05 mass%, particularly preferably 0.001 to 0.02 mass%.

  In the present invention, the blending ratio of the component (A) and the component (B) is based on the total amount of compounds of the formulas (1) and (2) in the component (A) (in terms of pure content) and the anti-inflammatory effect of the component (B). The mass ratio ((A) :( B)) to the agent is preferably 100: 1 to 1: 1,000, more preferably 35: 1 to 1: 500, and even more preferably 10: 1 to 1: 50. Within this range, the bad breath suppression effect is more excellent. It is preferable for the bad breath suppression that the ratio is not too large, and it is preferable for suppressing discoloration of the preparation that the ratio is not too small.

  The composition for oral cavity of the present invention is in the form of solid, solid, liquid, liquid, gel, paste, gum or the like, toothpaste such as toothpaste, liquid toothpaste, liquid toothpaste, or toothpaste, mouthwash It can be prepared into dosage forms such as preparations, gingival massage creams, oral pasta, mouthwashes, troches, chewing gums, etc., and its manufacturing method can also adopt conventional methods according to the dosage form, among which dentifrices and mouthwashes It is suitable as.

  In addition to the above-described components, the oral composition can be blended with known components according to the purpose, dosage form, and the like within a range that does not impede the effects of the present invention. A dentifrice, especially a toothpaste, can contain an abrasive, a thickener, a binder, a surfactant and, if necessary, a sweetener, a colorant, an antiseptic, a fragrance, an active ingredient, and the like. The mouthwash may contain a thickening agent, a surfactant, a solvent such as water, and a sweetener, a coloring agent, a preservative, a fragrance, an active ingredient, a buffering agent and the like as necessary.

  Examples of abrasives include silica-based abrasives such as anhydrous silicic acid, calcium phosphate-based abrasives such as dibasic calcium hydrogen phosphate, anhydrous and dihydrate, calcium carbonate, aluminum hydroxide, alumina, and synthetic resins. Can be mentioned. The blending amount is usually 5 to 60% by mass, and particularly preferably 10 to 55% by mass for toothpaste. In addition, an abrasive | polishing agent is not normally mix | blended with a mouthwash.

  Examples of the binder include synthetic binders such as alginic acid derivatives, gums, and polyvinyl alcohol, and inorganic binders such as silica gel (the amount is usually 0.3 to 10% by mass).

  Examples of the thickener include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin and propylene glycol (the amount is usually 1 to 70% by mass).

  As the surfactant, known surfactants usually blended, for example, nonionic surfactants such as polyoxyethylene hydrogenated castor oil having an average addition mole number of 40 to 100 of ethylene oxide (EO), sodium lauryl sulfate, etc. An anionic surfactant, an amphoteric surfactant, and a cationic surfactant can be blended. The blending amount of the surfactant is appropriately selected according to the form of the composition, the purpose of use and the like, and is usually 0 to 10% by mass for toothpaste, particularly 0.1 to 5% by mass, usually for liquid toothpaste and mouthwash. 0 to 5% by mass, particularly 0.3 to 3% by mass.

Examples of the sweetener include saccharin sodium. As the colorant, a commonly used pigment can be used. Examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof.
As a fragrance | flavor, the well-known fragrance | flavor normally used for the composition for oral cavity can be mix | blended suitably. For example, natural fragrances such as spearmint oil and peppermint oil, single fragrances such as carvone and anethole, further single fragrances, blended fragrances including natural fragrances, and the like are not limited to the fragrances of the examples. Further, the blending amount is not particularly limited, and can be a normal amount.

As an active ingredient, you may mix | blend well-known active ingredients, such as an enzyme, fluoride, vitamins, and those derivatives, for example in addition to the combined use system of this invention. The blending amount can be an effective amount as long as the effects of the present invention are not hindered.
As the buffer, citric acid or a sodium salt thereof can be used.
As the solvent, purified water is usually used, and a lower alcohol having 1 to 3 carbon atoms such as ethanol can also be added.

  EXAMPLES Hereinafter, although a preparation example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Preparation Example]
<Preparation of black moji extract>
5 kg of dry branch of Chinese black moji is heated and extracted twice with 25 L of 80% ethanol heated to 50 ° C. for 2 hours, cooled, solids are removed by filtration, and the filtrate is concentrated under reduced pressure at 50 ° C. or less. About 300 g of chromomy extract was obtained. Add 300 mL of 30% ethanol to 300 g of the resulting black moji extract, stir for 1 hour while warming to 50 ° C., and leave it for a whole day and night to discard the 30% ethanol soluble part, and 3,5-dihydroxy-2 -300 g of a rod-shaped extract containing 8.0% mentenyl stilbene and 7.3% 3,5-dihydroxystilbene was obtained.
After adding 1,500 mL of 50% ethanol to 300 g of the obtained rod-shaped extract, the stirring extraction was repeated twice for 1 hour, the insoluble part was discarded, and the soluble part was previously aged with 50% ethanol Diaion HP-20 ( It was adsorbed by circulating 3 times through Mitsubishi Chemical Corporation and eluted with 1,500 mL of 99.5% ethanol. Further, the adsorbent was washed with 1,000 mL of 99.5% ethanol, and concentrated under reduced pressure at 50 ° C. or lower together with the eluent described above, to give 9.56% of 3,5-dihydroxy-2-mentenylstilbene, 180 g of a soft extract containing 15.19% of 3,5-dihydroxystilbene was obtained (Preparation Example 1). Further, by treating the soft extract with acid clay and diatomaceous earth, 150 g of a soft extract containing 14.1% of 3,5-dihydroxy-2-mentenylstilbene and 16.6% of 3,5-dihydroxystilbene is obtained. Obtained (Preparation Example 2).

[Experimental example]
Using the soft extracts of Preparation Examples 1 and 2 as a chromodi extract, mouthwashes having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and evaluated as follows using this as a sample. The results are shown in Tables 1-3.

Details of the main raw materials used are shown below.
epsilon-aminocaproic acid; Tranexamic acid manufactured by Daiichi Sankyo Co., Ltd. (Japanese Pharmacopoeia compatible product); Dipotassium glycyrrhizinate manufactured by Simic CMO Co., Ltd .: Oubak extract manufactured by Maruzen Pharmaceutical Co., Ltd. (water dried extract, berberine content 5.0% ); Made by Koshiro Pharmaceutical Co., Ltd.

[Experimental example 1] Evaluation of bad breath (isovaleric acid) inhibitory effect 4 healthy subjects who have no systemic disease (age 40-59 years old) as subjects, oral cleaning with dentifrice and toothbrush from 3 days before analysis It stopped and only the oral cavity cleaning by the mouthwash of each Example and the comparative example was implemented. Specifically, after each meal and before going to bed, about 10 mL of the mouthwash of each Example and Comparative Example was included in the mouth and rinsed for 60 seconds. On the day of the analysis, oral cleaning after waking up and eating and drinking were stopped, and gas in the oral cavity (mouth) after the mouth was closed for 3 minutes was slowly discharged into a 200 mL analytic barrier bag. The mouth was kept warm in a 40 ° C. constant temperature bath immediately after collection. One hour later, 100 mL was adsorbed on NeedlEX for fatty acid (manufactured by Shinwa Chemical Co., Ltd.), and the amount of isovaleric acid in the mouth was quantified by gas chromatography mass spectrometry under the following conditions.
The rate of decrease in the amount of isovaleric acid in the mouth with respect to the control (a mouthwash having the same composition as in Examples and Comparative Examples except that the test sample (A) and the anti-inflammatory agent (B) were not added) (Valeric acid) inhibition rate.

Gas chromatograph mass spectrometry conditions Column: HP-INNOwax (inner diameter 0.25 mm, length 30 m, film thickness 0.25 μm)
Agilent Technologies, Inc. Column temperature: 80 ° C. (10 min) to 150 ° C. (5 ° C./min) to 250 ° C. (10 ° C. /
min)
Injection method: Splitless method (high pressure injection, 2 min)
Carrier gas: He (40 cm / sec)
Inlet temperature: 250 ° C
Detector: MS (m / z = 20-600)
Interface temperature: 250 ° C
Ion source temperature: 200 ° C

The following criteria evaluated from the said bad breath (isovaleric acid) suppression rate. The result of 5 points, 4 points and 3 points was judged to be a mouthwash having a high effect of suppressing bad breath (isovaleric acid).
Evaluation criteria for bad breath (isovaleric acid) inhibitory effect 5 points: inhibition rate of 90% or more 4 points: inhibition rate of 70% or more and less than 90% 3 points: inhibition rate of 50% or more and less than 70% 2 points: inhibition rate 30% or more and less than 50% 1 point: Less than 30%

[Experimental Example 2] Evaluation of Appearance Stability (Discoloration) The mouthwashes of Examples and Comparative Examples were stored at 5 ° C. and 60 ° C. for 1 month, and then stored at 5 ° C. for 1 month. The appearance stability (discoloration) of the products stored for 1 month was visually evaluated according to the following criteria. The samples with ◎ and ○ were judged to have good appearance stability (discoloration).
Evaluation criteria for appearance stability (discoloration) A: No change in color compared to the control product.
○: Almost no change in color compared to the control product.
Δ: There is a slight color change compared to the control product.
X: There is a color change compared to the control product.

[Example 19] Toothpaste (A) Chromoji extract (preparation example 2) 0.05%
(Equivalent value 3,5-dihydroxy-2-mentenylstilbene 0.00705%
3,5-dihydroxystilbene 0.0083%)
(B) ε-aminocaproic acid 0.05
Silicic anhydride 20
Sodium lauryl sulfate 1
Propylene glycol 3
Sorbit 30
Xanthan gum 1
Saccharin sodium 0.1
Fragrance 1
Sodium hydroxide
Purified water remaining
Total 100.0%

[Example 20] Liquid dentifrice (A) Chromoji extract (preparation example 2 products) 0.05%
(Equivalent value 3,5-dihydroxy-2-mentenylstilbene 0.00705%
3,5-dihydroxystilbene 0.0083%)
(B) Oat extract 0.05
Glycerin 25
Sorbit (70% aqueous solution) 25
Propylene glycol 5
Silicic anhydride 0.3
Sodium lauryl sulfate 1
Polyoxyethylene hydrogenated castor oil (EO average added mole number 60) 1
Saccharin sodium 0.2
Sodium benzoate 0.3
Fragrance 1
Purified water remaining
Total 100.0%

[Example 21] Mouthwash (A) Chromoji extract (Preparation Example 2) 0.02%
(Equivalent value 3,5-dihydroxy-2-mentenylstilbene 0.00282%
3,5-dihydroxystilbene 0.00332%)
(B) Dipotassium glycyrrhizinate 0.05
Xylitol 3
Glycerin 2
Polyoxyethylene hydrogenated castor oil (EO average added mole number 60) 0.5
Sodium citrate 0.3
Citric acid 0.1
Sodium benzoate 0.3
Methyl benzoate 0.1
Fragrance 0.2
Saccharin sodium 0.002
Propylene glycol 3
Polyethylene glycol # 400 5
Purified water remaining
Total 100.0%

Claims (9)

  3. An extract (A) from 3,5-dihydroxy-2-mentenylstilbene or chromodi containing 3,5-dihydroxystilbene or a subspecies thereof, and an anti-inflammatory agent (B) An oral composition.   The component (A) is an extract containing 3,5-dihydroxy-2-mentenylstilbene in an amount of 1% by mass or more of solids or 3,5-dihydroxystilbene in an amount of 1% by mass or more of solids. Oral composition.   The composition for oral cavity according to claim 1 or 2, wherein the component (B) is ε-aminocaproic acid and / or tranexamic acid.   The content of the component (A) is 0.0001 to 3.1% by mass in terms of the pure content of 3,5-dihydroxy-2-mentenylstilbene or 3,5-dihydroxystilbene, and the content of the component (B) is It is 0.002-1 mass%, The composition for oral cavity of Claim 1, 2, or 3.   The oral cavity according to any one of claims 1 to 4, wherein the blending ratio of the component (A) to the component (B) is (A) :( B) from 100: 1 to 1: 1,000 as a mass ratio. Composition.   The composition for oral cavity according to any one of claims 1 to 5, which is a mouthwash or a dentifrice.   A halitosis inhibitor comprising an extract (A) from 3,5-dihydroxy-2-mentenylstilbene or chromodi containing 3,5-dihydroxystilbene or a subspecies thereof, and an anti-inflammatory agent (B).   The component (A) is an extract containing 3,5-dihydroxy-2-mentenylstilbene in an amount of 1% by mass or more of solids or 3,5-dihydroxystilbene in an amount of 1% by mass or more of solids. Bad breath suppressant.   The malodor control agent according to claim 7 or 8, wherein the blending ratio of the component (A) and the component (B) is (A) :( B) from 100: 1 to 1: 1,000 as a mass ratio.