JPH0678220B2 - Composition for removing bad breath - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for removing halitosis which effectively removes halitosis by using an extract of sage and carvone in combination.

[0002]

[Background Art] [Problems to be Solved by the Invention] Oral compositions such as toothpaste and mouthwash clean the oral cavity,
It is used for cleaning and keeping the oral cavity hygienic. In this case, it is desired that the oral composition has a function of removing bad breath which gives a person an unpleasant feeling.

[0003]

Means and Actions for Solving the Problems The present inventors have
As a result of intensive research on a composition for removing halitosis having an excellent halitosis removing effect, it was found that halitosis can be reliably removed by using a sage extract and carvone together, and the present invention is made. It has come.

The present invention will be described in detail below. The present invention is a toothpaste such as a toothpaste, a moisturized toothpaste and a powdered toothpaste, a mouthwash,
It is a composition in which a sage extract and carvone are blended in a composition for removing bad breath such as pasta for oral use, troche, chewing gum, and gargle tablet.

In this case, the raw material used to obtain the sage extract is sage powder; the residue obtained by steam distilling the sage and other essential oil collecting residues; or sage, ethyl ether, ethylene chloride, dioxane. , Oleoresin and its extraction residue obtained by extraction with a polar solvent such as acetone, lower alcohol such as ethanol or methanol, ethyl acetate, propylene glycol, glycerin, water;
Hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,
One selected from oleoresin obtained by extraction with a nonpolar solvent such as 2-dichloroethane, toluene, benzene and the extraction residue thereof is used. If you want to obtain sage extract from these raw materials,
One or two or more species are subjected to extraction treatment with a polar solvent and / or a non-polar solvent (these solvents may be those exemplified above), and the extract (the extract or the solvent is distilled therefrom) Things). In the present invention, the extract can be used as it is, but the steam distillation residue obtained by steam distillation treatment of the extract, the extract or the steam distillation residue of activated carbon, diatomaceous earth, acid clay or the like. Those treated with an adsorbent, and the residue obtained by treating the extract with an adsorbent and then steam-distilling can also be suitably used as the sage extract. As the extraction method, a known method can be adopted, for example, a method of soaking the dried powder of sage in a solvent can be adopted. In this case, the solvent is preferably an organic solvent, and the organic solvent extract obtained by extracting sage with the organic solvent is more effective.

In the present invention, as the sage extract, one kind obtained by the above-mentioned method may be used, or two or more kinds may be used in combination.

The content of the sage extract in the composition for removing halitosis is 0.0005% (% by weight, the same applies hereinafter) to 5%, and particularly 0.05% to 2%. preferable.

In the present invention, carvone is used in combination with the above-mentioned sage extract, whereby these act synergistically to surely eliminate the bad odor of CH ₃ SH, which is the largest cause of bad breath, and to prevent the occurrence of bad breath. It can be suppressed well. On the other hand, even if the sage extract is used alone, the bad odor of CH ₃ SH cannot be completely removed, and the sage extract may be used as an essential oil, a fragrance component such as vanilla oil,
Even when used in combination with methyl anthranilate or the like, the effect of removing bad breath cannot be sufficiently obtained, and the object of the present invention cannot be achieved.

The carvone used in the present invention may be isolated or synthesized from an essential oil, and an essential oil containing carvone, for example, Spearmint oil (Spearmint).
Oil, native species and Scotch species) may be used as they are. Further, the content of carvone is preferably 0.01 to 2%, particularly preferably 0.05 to 1% of the total composition.

As the other component of the present invention, an appropriate component depending on the kind of the composition for removing bad breath is used. For example, in the case of toothpaste, dibasic calcium phosphate dihydrate and anhydride, calcium carbonate, calcium pyrophosphate,
Abrasives such as calcium sulfate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum hydroxide, aluminum oxide, and resin (the compounding amount is usually 20 to 60%), carboxymethyl cellulose, hydroxyethyl cellulose, alginate. , Carrageenan, gum arabic Binders such as polyvinyl alcohol (0.3-5%), thickeners such as polyethylene glycol, sorbitol, glycerin, propylene glycol (10-70%), sodium lauryl sulphate, dodecylbenzene sulfone Sodium acid, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, lauryl diethanol amide, citric acid Foaming agent such as sucrose fatty acid ester (0 to 5%), and saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, sweeteners such as p-methoxycinnamic aldehyde, thaumatin, preservatives, and other ingredients. It mixes with and is manufactured according to a conventional method. Further, in mouthwashes such as mouthwash and the like, components suitable for the properties of the product are appropriately mixed.

The composition for removing halitosis of the present invention includes lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or a salt thereof, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine. Salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E, sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble primary or secondary phosphate, quaternary ammonium compound,
An active ingredient such as sodium chloride can also be added.

[0012]

EFFECTS OF THE INVENTION The composition for removing bad breath according to the present invention uses the extract of sage and carvone in combination, so that they act synergistically to exert an effect on bad breath caused by the bad odor of CH ₃ SH. To suppress it.

[0013]

EXAMPLES Next, the effects of the present invention will be specifically described by showing experimental examples. [Experimental Example] To 100.0 g of dried sage powder was added 300 ml of methanol, and the mixture was refluxed for 1 hour on a water bath at 70 to 80 ° C with a cooling tube attached. Then the methanol fraction is filtered off,
Fresh methanol was added to the residue, the same reflux was repeated twice, and extraction operation was performed three times in total. The methanol extracts were combined and concentrated under reduced pressure to obtain 27.4 g of a dark green paste.

Other solvents are operated in the same manner as above,
Various extracts of sage were obtained. Table 1 shows the extraction results.

[0015]

[Table 1]

Next, human saliva is spun down (5000 rp).
m, 15 minutes, 4 ° C), after removing solid matter (white blood cells, bacterial cells), 2.5 ml of the solid product has a diameter of 25 mm and a height of 220 m.
The sage extract of various concentrations was added with ethanol to make 1.0 ml, and then the fragrance component (essential oil) was added at various concentrations. CH ₃
0.5 ml of an aqueous solution containing SH (100 ng of CH ₃ SH
Was added, the mixture was immediately capped and incubated at 37 ° C. for 5 minutes.

After the reaction, the cap was opened, and the panel was made up of 4 people.
Sensory evaluation was performed based on the following evaluation criteria using the odor of H ₃ SH as an index. Evaluation Criteria 3 points: Strong CH ₃ SH odor 2 points: CH ₃ SH odor 1 point: CH ₃ SH odor is suspected 0 points: CH ₃ SH no odor . The results are shown by the overall score of 4 panelists.

[0018]

[Table 2]

From the results shown in Table 2, it was found that the combined use of the sage extract and carvone act synergistically to eliminate the odor of CH ₃ SH.

Examples will be shown below. [Example 1] Toothpaste dicalcium phosphate dihydrate 50% Solbit 10 Glycerin 10 Sodium lauryl sulfate 2.0 Carboxymethyl cellulose 1.0 Carvone 0.7 Eugenol 0.05 Sage 80% Ethanol extract 0.1 Sodium monofluorophosphate 0.3 Ethanol 2.0 Saccharin 0.1 Mutanase 0.1 Water 100.0% remaining

[Example 2] Toothpaste Dicalcium phosphate dihydrate 50% Glycerin 20 Carboxymethyl cellulose 2.0 Sodium lauryl sulfate 2.0 Spearmint oil 1.0 Sage water extract 0.1 Chlorhexidine gluconate 0.01 Saccharin 0.1 Glycyrrhizic acid 0.2 Bentonite 0.5 Water Residual 100.0%

Example 3 Oral Pasta Polyoxyethylene Monostearate 2.0% Sorbitan Monooleate 2.0 Cetyl Alcohol 2.0 Palmityl Alcohol 3.0 Propylene Glycol 15.0 Carboxymethyl Cellulose 5.0 Gelatin 1.0 Saccharin 0.2 Sage methanol extract 0.1 Peppermint oil 0.5 Spearmint oil 0.5 Lysozyme chloride 5,000 units / g Chlorhexidine hydrochloride 0.01% Water 100.0% remaining

Example 4 Oral Pasta Glycerin Monolaurate 3.0% Oleyl Alcohol 5.0 Polyethylene Glycol 15.0 White Vaseline 3.0 N-Palmitoyl Glutamate Monosodium 0.5 Hydroxyethyl Cellulose 5.0 Sage Ethylene Chloride extract 0.05 Tocopherol acetate 0.1 Chlorhexidine hydrochloride 0.01 Saccharin 0.2 Japanese peppermint oil 0.7 Carvone 0.5 Anethole 0.3 Eugenol 0.1 Water remaining 100.0%

[Example 5] Lozenge gum arabic 6.0% Glucose 72.0 Gelatin 3.0 Fragrance 0.2 Dextranase 0.1 Chlorhexidine gluconate 0.01 Sage ethanol extract 0.1 l-menthol 0 1 Spearmint oil 0.1 Celerymethanol extract 0.1 Water 100.0% balance

Claims (1)

[Claims] 1. A composition for removing halitosis, which comprises using an extract of sage and carvone in combination.