JPH07309733A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a stable composition for the oral cavity having preventing effects on dental caries and periodontosis without any discoloration with time. CONSTITUTION:The characteristic of this composition for the oral cavity comprises blending an extract of Hovenia dulcis Thunb. with an extract of Foeniculi Fructus, an extract of Glycyrrhizae Radix and a least one of l-menthol and l-carvone therein.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stable oral composition which has an effect of preventing dental caries and periodontal disease and does not discolor over time.

[0002]

2. Description of the Related Art Oral compositions such as dentifrices contain plant extracts such as kenponashi and fennel which have a caries-preventing effect, but discoloration occurs with the addition of these extracts. There was a problem. In addition, the Kemponasi extract shows antibacterial activity against caries-causing bacteria (Japanese Patent Laid-Open No. 02-78).
No. 609), and fennel extract is disclosed to suppress plaque formation by inhibiting glucosyltransferase (JP-A-58-112218). However, Porphyromona is a pathogen of periodontal disease such as alveolar pyorrhea and gingivitis.
The effects on Gram-negative anaerobic bacteria such as S. gingivalis have not been investigated.

[0003]

That is, an object of the present invention is to provide a stable oral composition which has an effect of preventing dental caries and periodontal disease and does not discolor over time.

[0004]

Means for Solving the Problems As a result of intensive studies for achieving the above-mentioned objects, the present inventors have found that at least kaemphorni extract, fennel extract, licorice extract, and l-menthol or l-carvone. By adding one of them, higher antibacterial activity was exhibited, and it was found that there was no discoloration with time, and the present invention was completed.

Accordingly, the present invention is directed to a Kemponasi extract,
An oral composition comprising a fennel extract, a licorice extract and at least one of l-menthol and l-carvone.

The structure of the present invention will be described below. Examples of the extraction solvent for kenponashi, fennel and licorice include water, organic solvents such as methanol, ethanol, propylene glycol, acetone, ether, chloroform, hexane and ethyl acetate. The organic solvent may be used alone, or two or more kinds may be mixed, or water and the organic solvent may be used in combination.

[0007] The method for producing the kenponashi extract, fennel extract and licorice extract in the present invention may be prepared by a conventional method. For example, fruits or seeds of kenponasi, fennel plant or licorice plant are dried, pulverized and powdered. The soaked product (1 kg) was immersed in 50% water / ethanol mixed solvent (1: 1) at room temperature for one day and night,
Extract by filtration (10 g as dry residue
30 g) can be prepared. Alternatively, the solvent of the filtrate may be removed and powdered (solid content) may be used.

The l-menthol and l-carvone used in the present invention may be synthetic products or commercially available products.

In the case of the extract, the compounding concentration of the kenposhi extract, fennel extract and licorice extract in the present invention is 0.0 based on the total amount of the oral composition.
05 wt% to 5 wt% (hereinafter abbreviated as wt%), in the case of solid content, 0.00 based on the total amount of the oral composition.
5 wt% to 1 wt% is preferable. The blending concentration of l-menthol or l-carvone is from 0.05 wt% to
2 wt% is preferable.

Examples of the oral composition according to the present invention include toothpaste such as toothpaste, powder toothpaste, water toothpaste, mouthwash, mouth freshener, troche, pasta, and patch.
Other examples include chewing gum, candy, gummy candy, and candy.

The other compounding ingredients of the present invention are appropriately selected depending on the kind of the oral composition. For example, in the case of toothpaste, calcium carbonate, magnesium carbonate, dicalcium phosphate, and tertiary calcium which are commonly used as abrasives
Calcium phosphate, magnesium phosphate, silica, zeolite, sodium metaphosphate, aluminum hydroxide,
Examples thereof include magnesium hydroxide, calcium pyrophosphate, red iron oxide, calcium sulfate, and silicic acid anhydride.

Further, sodium carboxymethyl cellulose, hydroxyethyl cellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, methyl cellulose, magnesium oxide, alumina sol, calcium silicate, pectin, guar gum, kaolin and other binders, sodium lauryl sulfate, dodecyl. Sodium benzenesulfonate, sodium lauroyl sulfoacetate, N
A foaming agent such as sodium lauryl sulfonate, sodium N-lauroyl sarcosinate, sucrose fatty acid ester, polyoxyethylene sorbitan, and alkylolamide is used.

Furthermore, sweeteners such as sodium saccharin, stevisite, glycyrrhizin, chalcone and dihydrochalcone, moisturizers such as glycerin, sorbitol, propylene glycol, polyethylene glycol, chrysitol, dipropylene glycol, sodium lactate and maltitol, paraoxybenzoic fragrance. Preservatives such as acids, perfumes such as peppermint and essential oils of spearmint, aluminum lactate, edetates, pigments, BHT, etc. are used, and if necessary, other active ingredients such as lysozyme chloride, dextrase, lytic enzyme, mutanase, Sorbic acid, alexidine, cetylpyridinium chloride, alkylglycine, sodium chloride, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, sodium fluoride,
Fluorides such as sodium monofluorophosphate, isopropylmethylphenol, polyethylene glycol, polyvinylpyrrolidone, glycyrrhizin, glycyrrhizic acid, hinokitiol, vitamin E and the like can also be used. These components are mixed with water and produced according to a conventional method. Also,
In the case of mouthwash, troche, chewing gum and the like, the components suitable for the properties of the product are appropriately blended.

[0014]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. Prior to the description of the examples, test methods for antibacterial properties and storage stability will be described below.

[0015] (1) Porphyromona s antimicrobial test method for gingivalis 381 Porphyromona s gingivalis 381 anaerobic conditions in liquid medium, and cultured at 37 ° C., the bacteria are harvested by centrifugation After growth. Further, this bacterium is suspended in physiological saline to obtain a bacterium solution. A certain amount of the composition of Comparative Example and Example was added to this bacterial solution, and the mixture was incubated at 37 ° C. under anaerobic conditions and judged by visual observation. + Indicates antibacterial activity, and-indicates no antibacterial activity.

(2) Storage stability test method The degree of discoloration after storage at 40 ° C. for 3 months is examined. The examples and comparative examples were stored at 40 ° C. for 3 months and evaluated according to the following criteria. ×: Discolored and impairs product value ○: Undiscolored

Example 1 and Comparative Examples 1 and 2 Compositions of liquid dentifrices shown in Table 1 containing extracts of kenponashi, fennel and licorice and 1-menthol (Example 1), kenponashi and fennel One containing no substance, licorice extract and 1-menthol (Comparative Example 1), one containing kenponashi, fennel extract and 1-menthol (Comparative Example 2) were prepared.

[0018]

[Table 1]

[0019]

[Table 2] Table 2 shows the evaluations of the comparative examples and the examples.

Example 2 and Comparative Examples 3 to 4 Comparative examples and examples were prepared in the same manner as the above liquid dentifrice with the composition of toothpaste shown in Table 3.

[0021]

[Table 3]

[0022]

[Table 4] Table 4 shows the evaluations of the above comparative examples and examples.

Example 3 (Toothpaste) Based on the composition shown in Table 5, a toothpaste was prepared by a conventional method.

[0024]

[Table 5]

Example 4 (Toothpaste) Based on the composition shown in Table 6, a toothpaste was prepared by a conventional method.

[0026]

[Table 6]

Example 5 (Toothpaste) Based on the composition shown in Table 7, a toothpaste was prepared by a conventional method.

[0028]

[Table 7]

Example 6 (Ointment formulation) Based on the composition shown in Table 8, an ointment formulation was prepared by a conventional method.

[0030]

[Table 8]

Example 7 (Gel type oral pasta) A gel type oral pasta was prepared according to a conventional method based on the composition shown in Table 9.

[0032]

[Table 9]

Example 8 (lozenge) A lozenge was prepared according to a conventional method based on the composition shown in Table 10.

[0034]

[Table 10]

Example 9 (Gum formulation) Based on the composition shown in Table 11, a gum formulation was prepared by a conventional method.

[0036]

[Table 11]

[0037]

As described above, it is apparent that the present invention can provide a stable oral composition which is excellent in the preventive effect against dental caries and periodontal disease and which does not discolor over time.

Claims (1)

[Claims] 1. A Kemponasi extract, a fennel extract,
An oral composition comprising a licorice extract and at least one of l-menthol and l-carvone.