JPS6258328B2 - - Google Patents
Info
- Publication number
- JPS6258328B2 JPS6258328B2 JP55133846A JP13384680A JPS6258328B2 JP S6258328 B2 JPS6258328 B2 JP S6258328B2 JP 55133846 A JP55133846 A JP 55133846A JP 13384680 A JP13384680 A JP 13384680A JP S6258328 B2 JPS6258328 B2 JP S6258328B2
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- toothpaste
- organic solvent
- arnica
- cardamom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003960 organic solvent Substances 0.000 claims description 13
- 241000196324 Embryophyta Species 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 240000002943 Elettaria cardamomum Species 0.000 claims description 9
- 235000005300 cardamomo Nutrition 0.000 claims description 9
- 240000004371 Panax ginseng Species 0.000 claims description 7
- 235000008434 ginseng Nutrition 0.000 claims description 7
- 235000002789 Panax ginseng Nutrition 0.000 claims description 3
- 241000086254 Arnica montana Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 229940034610 toothpaste Drugs 0.000 description 12
- 239000000606 toothpaste Substances 0.000 description 12
- 208000002064 Dental Plaque Diseases 0.000 description 9
- 241000208983 Arnica Species 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 208000002925 dental caries Diseases 0.000 description 7
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229960003260 chlorhexidine Drugs 0.000 description 6
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 241000194017 Streptococcus Species 0.000 description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 208000028169 periodontal disease Diseases 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 201000001245 periodontitis Diseases 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 229920002307 Dextran Polymers 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- -1 N-acylglutamate Chemical class 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000401 methanolic extract Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 108010001682 Dextranase Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 description 2
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 230000007505 plaque formation Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 229960000414 sodium fluoride Drugs 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- AXCXHFKZHDEKTP-NSCUHMNNSA-N 4-methoxycinnamaldehyde Chemical compound COC1=CC=C(\C=C\C=O)C=C1 AXCXHFKZHDEKTP-NSCUHMNNSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 235000015701 Artemisia arbuscula Nutrition 0.000 description 1
- 235000002657 Artemisia tridentata Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 235000005769 Japanese ginseng Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 241000168720 Panax japonicus Species 0.000 description 1
- 235000003174 Panax japonicus Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- KGUHOFWIXKIURA-VQXBOQCVSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl dodecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCC)O[C@@H]1O[C@@]1(CO)[C@@H](O)[C@H](O)[C@@H](CO)O1 KGUHOFWIXKIURA-VQXBOQCVSA-N 0.000 description 1
- ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000007621 bhi medium Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229910002026 crystalline silica Inorganic materials 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
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- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
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- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000002032 methanolic fraction Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 235000019462 natural additive Nutrition 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- 235000015927 pasta Nutrition 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical group 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical group 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Chemical group 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- NTJHYIRSENEXDR-UHFFFAOYSA-M sodium;fluoro-dioxido-oxo-$l^{5}-phosphane;hydron Chemical compound [Na+].OP([O-])(F)=O NTJHYIRSENEXDR-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940032085 sucrose monolaurate Drugs 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
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- 229910052725 zinc Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
本発明はアルニカ、カルダモン、ゼンコ、チヨ
ウセンニンジン及びキヨウカツより選ばれる植物
の有機溶媒抽出物(粗エキス)を配合することに
より、歯垢の形成を抑制してう蝕及び歯周疾患を
予防する口腔用組成物に関する。
歯の表面に付着する歯垢は、約70%の細菌、細
菌により形成された約20%の多糖、及び約10%の
食物残渣よりなり、固く歯面にこびりついてい
る。そして、その内部に貯えられた酸がエナメル
質を脱灰し、菌及び産生された毒素が歯肉炎、歯
周炎、更には歯槽膿漏をもたらすといわれてお
り、口腔の二大疾患であるう蝕、歯槽膿漏の原因
として注目されている。
この歯垢はストレプトコツカス・ミユータンス
を中心とする口腔内細菌によつて口腔内に存在す
るシヨ糖を利用して形成される。即ち、ストレプ
トコツカス・ミユータンスはGTF(グルコシル
トランスフエラーゼ、デキストラン合成酵素)を
産生し、これによりシヨ糖からデキストラン、ム
タン等の粘着性多糖を合成する。そして、この合
成された多糖はストレプトコツカス・ミユータン
スをはじめ、他の菌(病原菌)を巻き込み、一定
の菌叢を有する歯垢を形成する。また、ストレプ
トコツカス・ミユータンス等の菌は種々の糖を利
用して酸を産生し、この酸は多糖及び菌の壁の中
に滞留することにより、エナメル表面を脱灰して
いく。更に、菌の死骸や産生された種々の物質、
毒素は歯肉に対して悪影響を及ぼし、歯槽膿漏の
原因として作用する。
従つて、歯垢の形成を抑制、阻止することは、
う蝕、歯周疾患を予防するという点から非常に有
効なことである。
本発明者らは、このような点を考慮し、う蝕、
歯周疾患の予防に好適な口腔用組成物につき鋭意
研究を行ない、天然物添加剤として種々の植物を
スクリーニングした結果、アルニカ、カルダモ
ン、ゼンコ、チヨウセンニンジン、キヨウカツの
有機溶媒抽出物がストレプトコツカス・ミユータ
ンスによる歯垢の形成を抑制し、従つて前記有機
溶媒抽出物が口腔用組成物の有効成分としてう
蝕、歯周疾患の予防に好適であることを知見し、
本発明をなすに至つた。
以下、本発明につき詳しく説明する。
本発明に係る口腔用組成物は練歯磨、粉歯磨、
水歯磨などの歯磨類、マウスウオツシユ、トロー
チ、パスタ、塗布剤、チユーインガム、うがい用
錠剤等として使用されるもので、有効成分として
アルニカ、カルダモン、ゼンコ、チヨウセンニン
ジン、キヨウカツの有機溶媒抽出物の1種又は2
種以上を配合してなるものである。
前記植物の抽出に用いる有機溶媒としては、メ
タノール、エタノール等の低級アルコール、アセ
トン、エチルエーテル、酢酸エチルなどの極性溶
媒、ベンゼン、ヘキサン、石油エーテル等の非極
性溶媒が使用でき、また含水メタノール、含水エ
タノール等の混合溶媒も使用し得る。本発明にお
いて有効成分として用いる有機溶媒抽出物は、上
述した植物をこれら有機溶媒の1種もしくは2種
以上の混合物、又はこれらの有機溶媒と水との混
合物で抽出し、その抽出残渣を除去し、必要に応
じて抽出液から溶媒を留去することによつて製造
できる。なお、抽出方法としては公知の方法が採
用でき、例えば有機溶媒中に前記植物の乾燥粉末
を温浸する等の方法が採用し得る。
前記有機溶媒抽出物の口腔用組成物中への配合
量は、全体の0.001〜5%(重量%、以下同じ)、
特に0.005〜2%とすることが好ましい。
本発明の他の成分としては、口腔用組成物の種
類に応じた適宜な成分が用いられる。例えば練歯
磨の場合であれば、第2リン酸カルシウム、炭酸
カルシウム、ピロリン酸カルシウム、不溶性メタ
リン酸ナトリウム、非晶質シリカ、結晶質シリ
カ、アルミノシリケート、酸化アルミニウム、水
酸化アルミニウム、レジン等の研磨剤、カルボキ
シメチルセルロース、ヒドロキシエチルセルロー
ス、アルギン酸塩、カラゲナン、アラビアガム、
ポリビニルアルコール等の粘結剤、ポリエチレン
グリコール、ソルビトール、グリセリン、プロピ
レングリコール等の粘稠剤、ラウリル硫酸ナトリ
ウム、ドデシルベンゼンスルホン酸ナトリウム、
水素添加ココナツツ脂肪酸モノグリセリドモノ硫
酸ナトリウム、ラウリルスルホ酢酸ナトリウム、
N−ラウロイルザルコシン酸ナトリウム、N−ア
シルグルタミン酸塩、シヨ糖脂肪酸エステル等の
発泡剤、それにペパーミント、スペアミント等の
精油、l−メントール、カルボン、オイゲノー
ル、アネトール等の香料素材などの香料、サツカ
リンナトリウム、ステビオサイド、ネオヘスペリ
ジルジヒドロカルコン、グリチルリチン、ペリラ
ルチン、p−メトキシシンナミツクアルデヒドな
どの甘味剤、防腐剤などの成分を水と混和し、常
法に従つて製造する。また、マウスウオツシユ等
の口腔洗浄剤その他においても、製品の性状に応
じた成分が適宜配合される。
なお、本発明においては、上述した植物の有機
溶媒抽出物に加えて塩化リゾチーム、デキストラ
ナーゼ、溶菌酵素、ムタナーゼ、クロルヘキシジ
ン、ソルビン酸、アレキシジン、ヒノキチオー
ル、セチルピリジニウムクロライド、アルキルグ
リシン、アルキルジアミノエチルグリシン塩、ア
ラントイン、ε−アミノカプロン酸、トラネキサ
ム酸、アズレン、ビタミンE、モノフルオロリン
酸ナトリウム、フツ化ナトリウム、フツ化第1
錫、水溶性第一もしくは第二リン酸塩、第四級ア
ンモニウム化合物、塩化ナトリウムなどの有効成
分を配合することもできる。
本発明に係る口腔用組成物は、アルニカ、カル
ダモン、ゼンコ、チヨウセンニンジン及びキヨウ
カツから選ばれる植物の有機溶媒抽出物の1種又
は2種以上を配合したことにより、ストレプトコ
ツカス・ミユータンスによる歯垢の形成を効果的
に抑制し、従つてう蝕の発生、歯周疾患を良好に
防止する。
次に実験例を示し、本発明の効果を具体的に説
明する。
〔実験例〕
カルダモンの乾燥粉末100gにメタノール300ml
を加え、70〜80℃の水浴上で冷却管を付けて1時
間還流した。次いでメタノール画分を別し、残
渣に新しいメタノールを加え、同様の還流を2回
繰り返し、計3回の抽出操作を行なつた。メタノ
ール抽出液はまとめて減圧濃縮し、褐色のペース
ト9.0gを得た。
第1表に示す他の植物についても上記と同様に
操作し、各植物のメタノール抽出物を得た。
次に、上記抽出物を試験試料とし、下記培養付
着法によりその歯垢形成抑制の度合を評価した。
培養付着法
1%のシヨ糖を含むBHI培地に上記試験試料を
0.1%添加し、これを前培養しておいたストレプ
トコツカス・ミユータンス6715株を接種し、
N2:CO2:H2=80:10:10にガス置換されたア
ナエロボツクスで37℃、16時間培養した。培養
後、0.01Mリン酸緩衝液(PH7.0)で静かに2回
洗浄し、次いで培養液と同量の同緩衝液を加えて
激しく撹拌し、約20秒間の超音波処理を行なつて
歯垢を均一に懸濁させた後、フオトメーターを用
いて550nmで吸光度(濁度)を測定し、付着歯垢
量を求めた。
結果を第1表に示す。なお、結果は試験試料を
添加しないコントロールの付着歯垢量を100%と
した場合の百分率で示した。
The present invention suppresses the formation of dental plaque and prevents caries and periodontal disease by blending organic solvent extracts (crude extracts) of plants selected from arnica, cardamom, zenko, ginseng, and chinensis. The present invention relates to oral compositions. Dental plaque that adheres to the tooth surface is made up of about 70% bacteria, about 20% polysaccharide formed by bacteria, and about 10% food residue, and is firmly stuck to the tooth surface. The acid stored inside demineralizes the enamel, and the bacteria and toxins produced are said to cause gingivitis, periodontitis, and even pyorrhea, two major oral diseases. It is attracting attention as a cause of caries and alveolar pyorrhea. This dental plaque is formed by oral bacteria, mainly Streptococcus miutans, using sucrose present in the oral cavity. That is, Streptococcus miutans produces GTF (glucosyltransferase, dextran synthase), which synthesizes sticky polysaccharides such as dextran and mutan from sucrose. This synthesized polysaccharide then attracts Streptococcus miutans and other bacteria (pathogens), forming dental plaque with a certain bacterial flora. Furthermore, bacteria such as Streptococcus miutans produce acids using various sugars, and this acid demineralizes the enamel surface by staying in the walls of polysaccharides and bacteria. Furthermore, dead bacteria and various substances produced,
Toxins have a negative effect on the gums and act as a cause of pyorrhea. Therefore, suppressing and preventing the formation of dental plaque is
This is extremely effective in preventing caries and periodontal disease. Taking these points into consideration, the present inventors have investigated caries, caries,
We conducted extensive research into oral compositions suitable for the prevention of periodontal diseases and screened various plants as natural additives. As a result, we found that organic solvent extracts of arnica, cardamom, zenko, ginseng, and Japanese cutlet were found to be effective as streptococcal ingredients. It has been found that the organic solvent extract suppresses the formation of dental plaque caused by C. myutans, and is therefore suitable as an active ingredient of an oral composition for preventing dental caries and periodontal disease.
The present invention has been accomplished. The present invention will be explained in detail below. The oral composition according to the present invention includes toothpaste, toothpaste,
It is used as toothpaste such as water toothpaste, mouthwash, pastilles, pasta, liniment, chewing gum, gargling tablets, etc.The active ingredients are organic solvent extracts of arnica, cardamom, zenko, ginseng, and chinensis. 1 or 2 of
It is made by blending more than one species. As the organic solvent used for extracting the plants, lower alcohols such as methanol and ethanol, polar solvents such as acetone, ethyl ether, and ethyl acetate, and nonpolar solvents such as benzene, hexane, and petroleum ether can be used. Mixed solvents such as aqueous ethanol may also be used. The organic solvent extract used as an active ingredient in the present invention is obtained by extracting the above-mentioned plants with one type or a mixture of two or more of these organic solvents, or a mixture of these organic solvents and water, and removing the extraction residue. can be produced by distilling off the solvent from the extract, if necessary. Note that a known method can be used as the extraction method, for example, a method such as digesting the dried powder of the plant in an organic solvent can be used. The amount of the organic solvent extract incorporated into the oral composition is 0.001 to 5% (wt%, same hereinafter) of the total,
In particular, it is preferably 0.005 to 2%. As other components of the present invention, appropriate components are used depending on the type of oral composition. For example, in the case of toothpaste, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, abrasives such as resin, carboxylic Methylcellulose, hydroxyethylcellulose, alginate, carrageenan, gum arabic,
Binder such as polyvinyl alcohol, thickening agent such as polyethylene glycol, sorbitol, glycerin, propylene glycol, sodium lauryl sulfate, sodium dodecylbenzenesulfonate,
Hydrogenated Coconut Fatty Acid Monoglyceride Sodium Monosulfate, Sodium Lauryl Sulfoacetate,
Foaming agents such as sodium N-lauroyl sarcosinate, N-acylglutamate, and sucrose fatty acid esters, essential oils such as peppermint and spearmint, fragrance materials such as l-menthol, carvone, eugenol, and anethole, and saccharin. It is produced by mixing ingredients such as sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, sweeteners such as p-methoxycinnamic aldehyde, preservatives, etc. with water and according to a conventional method. Furthermore, in mouthwashes and other mouthwashes, ingredients are appropriately blended depending on the properties of the product. In the present invention, in addition to the above-mentioned organic solvent extract of plants, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine are used. Salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E, sodium monofluorophosphate, sodium fluoride, fluoride 1
Active ingredients such as tin, water-soluble primary or secondary phosphates, quaternary ammonium compounds, sodium chloride, etc. can also be incorporated. The oral composition according to the present invention contains one or more organic solvent extracts of plants selected from arnica, cardamom, zenko, ginseng, and sagebrush. It effectively suppresses the formation of plaque, thus effectively preventing the occurrence of dental caries and periodontal disease. Next, experimental examples will be shown to specifically explain the effects of the present invention. [Experiment example] 100g of dry cardamom powder and 300ml of methanol
was added and refluxed for 1 hour on a 70-80°C water bath with a condenser attached. Next, the methanol fraction was separated, fresh methanol was added to the residue, and the same reflux was repeated twice, for a total of three extraction operations. The methanol extracts were collectively concentrated under reduced pressure to obtain 9.0 g of a brown paste. The other plants shown in Table 1 were operated in the same manner as above to obtain methanol extracts of each plant. Next, the above extract was used as a test sample, and its degree of inhibition of plaque formation was evaluated by the culture attachment method described below. Culture attachment method: Place the above test sample on BHI medium containing 1% sucrose.
Streptococcus miutans strain 6715, which had been pre-cultured with 0.1%, was inoculated.
The cells were cultured at 37° C. for 16 hours in an Anaerobox gas exchanged with N 2 :CO 2 :H 2 =80:10:10. After culturing, gently wash twice with 0.01M phosphate buffer (PH7.0), then add the same amount of the same buffer as the culture solution, stir vigorously, and perform ultrasonication for about 20 seconds. After the dental plaque was homogeneously suspended, the absorbance (turbidity) was measured at 550 nm using a photometer to determine the amount of attached dental plaque. The results are shown in Table 1. The results are expressed as a percentage, with the amount of plaque attached to the control to which no test sample was added as 100%.
【表】
上記の結果より、第1表に示す各植物のメタノ
ール抽出物は歯垢の形成を効果的に抑制すること
が知見された。
以下、実施例を示す。なお、%はいずれも重量
%を示す。また、下記例において植物はいずれも
そのメタノール粗エキスを用いた。
〔実施例1〕 練歯磨
第2リン酸カルシウム・2水和物 50.0%
グリセリン 20.0
カルボキシメチルセルロース 1.0
ソジウムラウリルサルフエート 1.0
香 料 1.0
アルニカ 0.1
カルダモン 0.1
サツカリン 0.1
フツ化ナトリウム 0.1 水 残
100.0%
〔実施例2〕 練歯磨
第2リン酸カルシウム・2水和物 50.0%
ソルビツト 10.0%
グリセリン 10.0
カルボキシメチルセルロース 1.0
ソジウムラウリルサルフエート 2.0
香 料 1.0
サツカリン 0.1
チヨウセンニンジン 0.1
モノフルオロリン酸ナトリウム 0.3
エタノール 2.0
ムタナーゼ 0.1 水 残
100.0%
〔実施例3〕 練歯磨
炭酸カルシウム 50.0%
グリセリン 20.0
カラゲナン 0.5
カルボキシメチルセルロース 1.0
ラウリルジエタノールアマイド 1.0
シヨ糖モノラウレート 2.0
香 料 1.0
ゼ ン コ 0.1%
キヨウカツ 0.1
サツカリン 0.1
クロルヘキシジン 0.005
デキストラナーゼ 0.01 水 残
100.0%
〔実施例4〕 練歯磨
第2リン酸カルシウム・2水和物 50.0%
グリセリン 20.0
カルボキシメチルセルロース 2.0
ソジウムラウリルサルフエート 2.0
香 料 1.0
サツカリン 0.1
アルニカ 0.1
チヨウセンニンジン 0.05
クロルヘキシジン 0.01 水 残
100.0%
〔実施例5〕 練歯磨
無水ケイ酸 30.0%
グリセリン 30.0
ソルビツト 20.0
カルボキシメチルセルロース 1.0
ソジウムラウリルサルフエート 2.0
香 料 1.0
サツカリン 0.1
カルダモン 0.05
ゼ ン コ 0.1
エタノール 2.0 水 残
100.0%
〔実施例6〕 粉歯磨
第2リン酸カルシウム・2水和物 50.0%
炭酸カルシウム 30.0
グリセリン 10.0
α−オレフインスルフオネート 1.0
香 料 1.0
サツカリン 0.1
キヨウカツ 0.1
アルニカ 0.05%
モノフルオロリン酸ナトリウム 0.1
デキストラン 0.5 水 残
100.0%
〔実施例7〕 液状歯磨
ポリアクリル酸ナトリウム 50.0%
グリセリン 30.0
香 料 0.9
サツカリン 0.1
クロルヘキシジン 0.01
ゼ ン コ 0.05
キヨウカツ 0.05
エタノール 3.0
リノール酸 0.05 水 残
100.0%
〔実施例8〕 マウスウオツシユ
エタノール 20.0%
香 料 1.0
サツカリン 0.05%
モノフルオロリン酸ナトリウム 0.1
クロルヘキシジン 0.01
ラウリルジエタノールアマイド 0.3
キヨウカツ 0.05
チヨウセンニンジン 0.05 水 残
100.0%
〔実施例9〕 うがい用錠剤
炭酸水素ナトリウム 54.0%
第2リン酸ナトリウム 10.0
ポリエチレングリコール 3.0
クエン酸 17.0
硫酸ナトリウム(無水) 13.6
香 料 2.0
オレイン酸 0.1
モノフルオロリン酸ナトリウム 0.1
クロルヘキシジン 0.05
アルニカ 0.1 キヨウカツ 0.05
100.0%
〔実施例10〕 歯肉マツサージクリーム
白色ワセリン 8.0%
プロピレングリコール 4.0
ステアリルアルコール 8.0
ポリエチレングリコール4000 25.0
〃 400 37.0
シヨ糖ステアリン酸エステル 0.5
ゼ ン コ 0.2
デキストラナーゼ 1.0 水 残
100.0%
〔実施例11〕 チユーインガム
ガムベース 43.85%
炭酸カルシウム 2.0
水 ア メ 15.0
粉 糖 30.0
シヨ糖パルミテート 1.0
フルクトース 4.0
マルトース 3.0
カルダモン 0.05%
キヨウカツ 0.1 香 料 1.0
100.0%[Table] From the above results, it was found that the methanol extracts of each plant shown in Table 1 effectively suppress the formation of dental plaque. Examples are shown below. Note that all % indicates weight %. Furthermore, in the following examples, methanol crude extracts of plants were used. [Example 1] Toothpaste dicalcium phosphate dihydrate 50.0% Glycerin 20.0 Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 1.0 Fragrance 1.0 Arnica 0.1 Cardamom 0.1 Saccharin 0.1 Sodium fluoride 0.1 Water Remaining 100.0% [Example 2] Toothpaste dicalcium phosphate dihydrate 50.0% Sorbit 10.0% Glycerin 10.0 Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 2.0 Flavoring 1.0 Satucalin 0.1 Panax ginseng 0.1 Sodium monofluorophosphate 0.3 Ethanol 2.0 Mutanase 0.1 Water Remaining 100.0 % [ Example 3] Toothpaste Calcium carbonate 50.0% Glycerin 20.0 Carrageenan 0.5 Carboxymethyl cellulose 1.0 Lauryl diethanolamide 1.0 Sucrose monolaurate 2.0 Flavoring 1.0 Zinc 0.1% Kiyokatsu 0.1 Satucalin 0.1 Chlorhexidine 0.005 Dextranase 0. 01 Wednesday 100.0% remaining [ Example 4 Toothpaste dicalcium phosphate dihydrate 50.0% Glycerin 20.0 Carboxymethyl cellulose 2.0 Sodium lauryl sulfate 2.0 Fragrance 1.0 Satucharin 0.1 Arnica 0.1 Panax ginseng 0.05 Chlorhexidine 0.01 Water Remaining 100.0% [Example 5] training Toothpaste silicic anhydride 30.0% Glycerin 30.0 Sorbit 20.0 Carboxymethyl cellulose 1.0 Sodium lauryl sulfate 2.0 Fragrance 1.0 Satucalin 0.1 Cardamom 0.05 Zenko 0.1 Ethanol 2.0 Water Balance 100.0% [Example 6] Toothpaste dibasic calcium phosphate dihydration Materials 50.0% Calcium carbonate 30.0 Glycerin 10.0 α-olefin sulfonate 1.0 Flavor 1.0 Satucalin 0.1 Kiyokatsu 0.1 Arnica 0.05% Sodium monofluorophosphate 0.1 Dextran 0.5 Water Balance 100.0% [Example 7] Liquid toothpaste Sodium polyacrylate 50.0 % Glycerin 30.0 Flavor 0.9 Satucalin 0.1 Chlorhexidine 0.01 Zenko 0.05 Kiyokatsu 0.05 Ethanol 3.0 Linoleic acid 0.05 Water Remaining 100.0% [Example 8] Mouthwash Ethanol 20.0% Flavor 1.0 Satucalin 0.05% Mono Sodium fluorophosphate 0.1 Chlorhexidine 0.01 Lauryl Diethanolamide 0.3 Japanese cutlet 0.05 Japanese ginseng 0.05 Water remaining 100.0% [Example 9] Gargle tablets Sodium bicarbonate 54.0% Sodium dibasic phosphate 10.0 Polyethylene glycol 3.0 Citric acid 17.0 Sodium sulfate (anhydrous) 13.6 Fragrance 2.0 Oleic acid 0.1 Sodium monofluorophosphate 0.1 Chlorhexidine 0.05 Arnica 0.1 Kiyokatsu 0.05 100.0% [Example 10] Gingival pine surge cream White petrolatum 8.0% Propylene glycol 4.0 Stearyl alcohol 8.0 Polyethylene glycol 4000 25.0 〃 400 37.0 Sugar starch Phosphate ester 0.5 Zenko 0.2 Deki Stranase 1.0 Water remaining 100.0% [Example 11] Chewing gum gum base 43.85% Calcium carbonate 2.0 Water Candy 15.0 Powdered sugar 30.0 Sucrose palmitate 1.0 Fructose 4.0 Maltose 3.0 Cardamom 0.05% Kiyokatsu 0.1 Flavor 1.0 10 0.0%
Claims (1)
ニンジン及びキヨウカツから選ばれる植物の有機
溶媒抽出物の1種又は2種以上を含有することを
特徴とする口腔用組成物。1. An oral composition characterized in that it contains one or more organic solvent extracts of plants selected from arnica, cardamom, Zenko, Panax ginseng, and Japanese cutlet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55133846A JPS5758611A (en) | 1980-09-26 | 1980-09-26 | Composition for oral cavity application |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55133846A JPS5758611A (en) | 1980-09-26 | 1980-09-26 | Composition for oral cavity application |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5758611A JPS5758611A (en) | 1982-04-08 |
JPS6258328B2 true JPS6258328B2 (en) | 1987-12-05 |
Family
ID=15114394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55133846A Granted JPS5758611A (en) | 1980-09-26 | 1980-09-26 | Composition for oral cavity application |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5758611A (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58121218A (en) * | 1982-01-07 | 1983-07-19 | Rooto Seiyaku Kk | Tooth decay preventive |
JPS60228419A (en) * | 1984-04-27 | 1985-11-13 | Kao Corp | Preventive for gingivitis |
JPH0635377B2 (en) * | 1984-07-30 | 1994-05-11 | ライオン株式会社 | Oral composition |
DE3437679C1 (en) * | 1984-10-15 | 1985-08-29 | Richardson GmbH, 6080 Groß-Gerau | Preparation against bad breath |
KR0128494B1 (en) * | 1994-07-26 | 1998-04-04 | 최무섭 | Heab medicine extract-containing non-bleeding striped dentifrice composition |
EP2324821A1 (en) | 2001-02-28 | 2011-05-25 | Axiomedic Ltd. | Oral care compositions |
JP2006248902A (en) * | 2005-03-08 | 2006-09-21 | Clean Eco Kk | Dentifrice and method for producing the same |
JP5675178B2 (en) * | 2010-06-09 | 2015-02-25 | 大島 光宏 | Collagen degradation inhibitor |
CN107811924A (en) * | 2017-12-14 | 2018-03-20 | 柳州市象行教育科技有限责任公司 | A kind of mouthwash and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB963780A (en) * | 1962-08-16 | 1964-07-15 | Inder Sain | A dental medicament |
US4198393A (en) * | 1977-08-24 | 1980-04-15 | International Flavors & Fragrances Inc. | Cyclic acetals of 2-methyl-2-pentenal and food flavor uses thereof |
-
1980
- 1980-09-26 JP JP55133846A patent/JPS5758611A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB963780A (en) * | 1962-08-16 | 1964-07-15 | Inder Sain | A dental medicament |
US4198393A (en) * | 1977-08-24 | 1980-04-15 | International Flavors & Fragrances Inc. | Cyclic acetals of 2-methyl-2-pentenal and food flavor uses thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5758611A (en) | 1982-04-08 |
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