JPH03220117A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity having immediate effects on ordinary foul breath, excellent effects on removal of garlic smell and alcohol smell, etc., comprising crude drug powder such as mint or thyme and an inclusion compound, by adjusting the components to a specific pH. CONSTITUTION:Crude drug powder or water extract selected from mint, thyme, ginger, hydrangea and clove is blended with an inclusion compound (e.g. cyclodextrin and grade of food and drug raw material is used) and optionally dextranase of bacterial plaque decomposing enzyme and adjusted with a pH adjuster such as magnesium oxide or anhydrous calcium hydrogenphosphate to give the title composition. The amount of water extract of the crude drug added to the oral cavity composition is 0.001-20wt.% calculated as solid content based on the whole amounts of the composition and when the crude drug is in powder, the amount is 0.01-50wt.% based on the whole amounts of the composition. The amount of the inclusion compound added is 0.1-50wt.% calculated as solid content based on the whole amounts of the composition. The composition is used as troche, dentifrice, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to an oral composition having an excellent halitosis removing effect.

(Prior Art) Chlorophyll, β-cyclodextrin, green tea flavonoids, lecithin, and the like are generally known as components having a bad breath removing effect.

Although these ingredients have been recognized to have a bad breath removal effect, no product has been found that satisfies all the requirements.

For example, -chlorophyll has a high halitosis-removing effect on normal bad breath (generally referred to as methyl mercaptan odor) and is a promising ingredient. It is highly toxic and stains the inside of the oral cavity a dark green color. Although coloring can be avoided if used at low concentrations, the halitosis removal effect is insufficient. Further, almost no effect is observed on garlic odor or alcohol odor.

Furthermore, although β-cyclodextrin has a high effect on removing bad breath from garlic and alcohol, it is not very effective against normal bad breath.

Furthermore, lecithin or green tea flavonoids are not very effective against common bad breath, garlic odor, alcohol odor, etc.

(Problems to be Solved by the Invention) The present invention provides an oral composition that has a high removal effect on both normal breath odor (especially mercaptan odor) and garlic odor (especially diallyl disulfide odor). The purpose is to

(Means for Solving the Problems) The present inventors have conducted studies to obtain a halitosis remover that has a high deodorizing effect on various types of bad breath and can be easily produced. Alternatively, they have found a solution that satisfies the above requirements by incorporating a water extract (water-soluble fraction), an clathrate compound, and, in some cases, a dental plaque degrading enzyme dextranase. That is, the present invention provides an oral composition containing a powder or water extract of a herbal medicine selected from the group consisting of mint, thyme, sagebrush, amacha, and jouno, and a clathrate compound, and whose pH is adjusted to 6 to 11. .

The herbal medicines used in the present invention are peppermint, thyme, chinensis, amacha, or chitauno, and their dry powders or water extracts are used. Herbal medicines may be used alone or in mixtures.

The raw materials used to obtain the aqueous extracts of the above herbal medicines include dried herbal medicines, dried shreds, dry powders, etc.; The residue obtained by extracting oil from these by steam distillation is used as other essential oil extraction residues: or herbal medicines. Oleolenones and their extraction residues obtained by extracting them with ethyl ether, ethylene chloride, dioxane, acetone, lower alcohols such as ethanol and methanol, and polar solvents such as ethyl acetate, propylene glycol, and glycerin;
-'\xane, petroleum ether, ligroin, noclohexane, carbon tetrachloride, chloroform, dichloromethane, 1
．． Those selected from oleoresins obtained by extraction with nonpolar solvents such as 2-dichloroethane, toluene, and Hensen and their extraction residues are used. When obtaining water extracts of the above crude drugs from these raw materials, one or more of these raw materials are extracted with water, and the extract (extract liquid or water distilled from it) is collected. It is preferable. During extraction, a water-soluble organic solvent (eg, alcohol, ketone) may be added up to about 50% by weight if necessary.

In the present invention, this extract can be used as it is or as a concentrate, or this extract can be used as a steam distillation residue obtained by steam distillation, or this extract or the steam distillation residue can be used as a steam distillation residue, The extract treated with an adsorbent such as diatomaceous earth or acid clay, and the residue obtained by steam distillation after treating the extract with an adsorbent can also be suitably used as the aqueous extract of the present invention. reactor. In addition, the extract can be concentrated under reduced pressure, freeze-dried,
Water may be distilled off and used by a method such as spray drying. Note that any known extraction method can be used, but it is preferable to add at least the same weight to the dried herbal medicine, for example.
Preferably, 5 to 10 times the weight of water is added and the mixture is heated at room temperature or under boiling for 0.5 to 24 hours, preferably 3 to IO.
A method is employed in which a time extraction process is performed, and after the extraction process, the extract is separated into an extract and an extraction residue by a conventional method such as filtration, centrifugation, decanting, etc., preferably under heating. In this case, if necessary, the extraction residue may be subjected to the same extraction process again to obtain an extract, which can be used in combination with the previous extract.

The clathrate compound used in the present invention may be any food or pharmaceutical raw material grade, and 7 clodextrin, maltosyl cyclodextrin, etc. are mainly used, but are not limited to these. Cyclodextrin (hereinafter referred to as “CD”)
It is sometimes abbreviated as. ) is α-CD1β-CD, γ-C
D, or a mixture thereof. Maltosylcyclodextrin (hereinafter sometimes abbreviated as rMcD) is a general term for α-CD1β-CD, γ-CD with one molecule of maltose linked α-1,6, and M-α
-CD, M-β-CD, M-γ-CD, or a mixture thereof.

The dextranase used in the present invention is an enzyme that decomposes dextran, which is the main component of dental plaque in which living bacteria that cause bad breath tend to exist. By decomposing dental plaque, it is expected that the number of living bacteria that cause bad breath will be reduced. This enzyme may be either an endo-type enzyme that randomly degrades dextran, or an exo-type enzyme that degrades dextran into glucose units from its reducing end.

The oral composition of the present invention needs to have a pi-t of 6 to 11, preferably 75 to 9.5. l) I-(
If the pH is less than 6, the bad breath removal effect will be poor, and if the pH is less than 11.
It is not suitable for use as an oral composition. This p
H is measured in aqueous solution after the composition is formed. Therefore, it is not preferable for the pH to deviate from the above range due to additives such as fragrances added to the composition. Usually a p[1 adjuster is added to bring the pH to the range of the invention.

Examples of pH-adjusting agents include magnesium oxide, magnesium oxide, magnesium silicate, tetrasodium pyrophosphate (anhydrous), disodium phosphate (anhydrous), dipotassium phosphate, and magnesium aluminate silicate, as well as synthetic hydrochloride. Examples include talcite, synthetic aluminum silicate, magnenium alumina hydroxide, precipitated calcium carbonate, calcium hydrogen phosphate (anhydrous), sodium hydrogen phosphate, and sodium hydroxide.

The amount of magnesium oxide, sodium hydroxide, and carnoum oxide is 0.01-10% of the total, preferably 0.
．． It is 1 to 8.0%. If the amount is more than this, the pH will be 11 or more and your mouth will feel watery, and if it is less than 6, the pH will be 6.
cannot be maintained. In addition, other pH 114 regulators are 0.
It is 1 to 40%, preferably 1.0 to 20%. If the amount is more than this, the flavor and texture will not be suitable, and if it is less than this, it will not be possible to maintain pH 6.

In the present invention, oral compositions include troches, tablets, round nets, candies, drinks, chewing gum, jelly, mouthwashes, oral pasta, toothpastes, toothpastes such as toothpastes, toothpaste powders, etc. .

The amount of the aqueous extract of the herbal medicine added to the oral composition is 0.001 to 20% of the total solid content, particularly 0.003%.
It is preferable to set it to 10%.

If it is less than 0001%, the bad breath removal effect cannot be expected.
Moreover, if it exceeds 20%, the flavor and formulation properties will be inappropriate, which is undesirable. More preferably, it is blended in an amount of 0.005 to 5%. In the case of crude drug powder, the total composition is 0. O1~
50% by weight, preferably from 0.5 to 25% by weight.

If the amount is less than this amount, the flavor and formulation properties are not suitable, and if the amount is less than this amount, the bad breath removal effect cannot be expected.

The amount of the above-mentioned clathrate compound added to the oral composition is 0.1 to 50% by weight, preferably 5 to 25% by weight of the total solid content.
Weight%. If the amount is more than this, the texture and formulation properties will be unfavorable, and if it is less than this, the halitosis removal effect will be poor.

The amount of the above-mentioned dextranase added to the oral composition is o,oot to 0.1% by weight of the total solid content, preferably 0.01=0.05% by weight.

Even if the amount is more than this, the effect of removing bad breath cannot be expected and the flavor is not suitable, and if it is less than this, the effect of decomposing plaque is poor.

The oral composition of the present invention may contain appropriate components depending on the type. For example, in the case of troches, excipients such as glucose, lactose, and sucrose, binders such as gum arabic, crystalline cellulose, and sodium carboxymethylcellulose, disintegrants such as starch, crystalline cellulose, and calcium carboxymethylcellulose, and magnesium stearate. , a lubricant such as sugar fatty acid ester, a sweetener such as sodium saccharin and glycyrrhizin, and a flavoring agent, and are produced according to a conventional method. Furthermore, in tablets, pills, candies, and drinks, ingredients are appropriately blended according to the properties of the product.

Furthermore, the oral composition of the present invention includes natural chlorophyll,
Active ingredients such as copper chlorophyllin sodium, iron chlorophyllin sodium, lecithin, lysozyme chloride, and Q-menthol can also be blended.

(Effects of the Invention) The oral composition according to the present invention is quick-acting and excellent against normal bad breath, because it contains crude drugs and adjusts the pH, and also contains plaque-degrading enzyme dextranase. Due to the presence of clathrate compounds, it has an excellent effect on removing bad breath from garlic, alcohol, and other odors.

(Example) The present invention will be explained in more detail with reference to Examples.

The present invention should not be construed as being limited to these examples.

Example 1 The effectiveness of removing methyl mercaptan (MM) was measured for dried powders of pepper, thyme, sagebrush, clove, and amacha, suikokisu, and acetone extract. The measurements were performed as follows.

The following experiment was conducted using the obtained specimen. 22-23
m (Put 5-101q of extract in a 1-volume test tube, 0.1M
Add phosphate buffer pH 7.0.3m.

Seal tightly with a silicone cap, stir, add 3QOng of methyl mercaptan, and shake for 3 minutes.

A gas of 1.0z (2) was collected from the headspace and immediately subjected to gas chromatography (detector FPD).

The results were expressed as the residual rate of methyl mercaptan, which is an indicator of general bad breath, using the following calculation formula. The results are shown in Table-1. As a control, the same amount of lactose was added instead of the sample and the same procedure was performed.

Residual rate (%) --X100 Methyl mercaptan a change when adding S extract (ng/l
,0. y C9 control methyl mercaptan i! 2 (ng/1.0a
Prepared as in Q).

Roughly crush the dried herbal medicine in a mill and add 100g of f2 powder to 1rho of water.
was added and left at room temperature for 12 hours, and then the aqueous extract was filtered off. The aqueous extract is concentrated under reduced pressure to obtain a brown paste.

Acetone Extract 1 g of acetone was added to IQOg powder obtained by crushing dried herbal medicine using a mill, and the mixture was left at room temperature for 12 hours, and then the acetone extract was filtered. The acetone extract is concentrated under reduced pressure to obtain an oily extract.

Example 2 The following experiment was conducted to investigate the relationship between pH and methyl mercaptan removal ability.

In a 22-231 g test tube, put 3 zg each of thyme and pepper, and 10 x g each of ginger, amacha, and clove, and add 2nd Q of purified water.

Adjust the pH to 5, 7, 8, 9 with hydrochloric acid or sodium hydroxide, and make the total amount 3yrQ. Thereafter, the residual rate of methyl mercaptan at each pH was determined in the same manner as in Example 1,
It is shown in FIGS. 1 to 5.

Example 3 The effectiveness of removing garlic-smelling noarylnosulfite (DADS) was measured using β-enclodextrin or maltone lunochlodextrin (α:β・γ=6:3:1). . The following experiment was conducted using the obtained specimen. That is, put 0.5 g of dried garlic powder into a 22-23 mQ test tube and add 1 Oy (l) of purified water. After stirring, add a certain amount of the sample shown in Table 2, seal it with a silicone cap, stir, and leave at room temperature for 1 hour. Leave to stand. Gas of 10 mσ was collected from the head space and immediately subjected to gas chromatography (detector FPD).The results were expressed as the residual rate of DADS, which is an indicator of garlic odor, using the following calculation formula.The results are shown in Table- 2. As a control, the same amount of lactose was added instead of the sample and the same operation was performed.

Residual rate (%) = -xlOOS: DADSIIt degree at the time of sample addition (ng/l,
OmQ)C: Control DADS concentration (ng/1, 0
ip) Table-2 Measuring the dextran (main component of dental plaque) decomposition rate of endo-type dextranase produced by Benithurium 1
-ta. The following experiment was conducted using the obtained sample.

Using dextran as a substrate, the amount of reducing sugar produced by the enzymatic reaction was measured using the Somogyi-Nelson method.
1son method). That is, a 2% dextran solution 1.0:J & acetate buffer (pH 7).

0:)2. After adding Ox (!), 100 μg of the above enzyme was added and reacted at 37°C for the time shown in Table 3. The resulting reducing sugar was measured by the Somoky-Nelson method to determine the decomposition rate, which is shown in Table 3. Ta.

Production 1 example 2 [lozenge (%) Maltononochlodextrin corn starch glucose gelatin fragrance Hatsuka time Calcium hydrogen phosphate anhydrous water total l　Olo 0 90 0 2 5.0 2.0 15.0 Residue Too,.

D-cutting example 3: Troche (%) dextranase glucose β-cyclodextrin copper chlorophyllin sodium Noyoukyo clove fragrance Magnesium stearate Magnenium silicate total 01 59.5 10.0 0.3 5, O 15.0 0,l O,1 1010 100,0 Table-3 reaction time Decomposition rate (%) 5 2 Formulation examples are shown below. In addition, all percentages indicate weight percent.

2 formulation example 1 [round net β-cyclodextrin Asenyaku daylily Keihi fennel Hatsuka time Noyoukyo clove amateur corn starch magnesium oxide total 100.0 ! Formulation example 41 Candy (%) Maltononochlodextrin Granulated sugar Starch syrup amateur flavored food fragrance Anhydrous disodium phosphate 40 00 34.9 15.0 1.0 0.1 0 total [Formulation Example 5 Drink preparation 100.0 (%) Maltone cyclodextrin fructose glucose liquid sugar honey amateur dipotassium phosphate fragrance synthetic preservatives purified water 5.0 5.0 5.0 0.02 0.3 0.1 0.01 B2.67 total [Formulation Example 6] Chewing gum β-cyclodextrin t　　　　.

(%) 5.0 Gum hese carbonate lunium starch syrup powdered sugar peppermint oil dextranase powdered anhydrous disodium phosphate water total 1 formulation example 7E Gargle tablets maltonorne clodextrin dipotassium phosphate sodium bicarbonate dibasic phosphate Sodium polyethylene glycol Fragrance Sodium oleate monofluorophosphate Chlorhexidine Hydrochloride Clove powder Allanthin Citric acid (%) 0 3 4 0 3, O 1,0 0,1 1 O805 2,0 1 70 Water balance 000 [Formulation example 8; Mouth rinse Maltonorne Chlodextrin Ethanol Sodium saccharin Flavor Sodium monofluorophosphate Chlorhexidine gluconate Lauryl jetanol Amide Thyme powder Glycyrrhizinate Allantoin Dipotassium phosphate water (%) 0 20.0 0.05 5 0.1 0.01 0.3 0.1 0.1 Oll 3 Remaining 2 Preparation Example 9] Toothpaste β-cyclodextrin diphosphoric acid dihydrate sorbitol glycerin 1 00.0 (%) 0 40.0 10. 0 5.0 Sonorum lauryl sulfate 20 carboxymethyl cellulose sodium 1.0 h
20 Sodium chloride
Magnenium 20 oxide
0.3 fragrance
1.0 water
Remaining total too.

[Brief explanation of drawings]

1 to 5 are diagrams showing the relationship between the residual rate of methyl mercaptan and pH of the single material of Example 2. In the valley diagram, the vertical axis represents the residual rate of methyl mercaptan, and the horizontal axis represents the pH.
Show value. Figure 1 is 3mg time, Figure 2 is 3mg Hatsuka, Figure 3 is 10mg ginger, Figure 4 is 10mg.
Figure 5 is for samples each containing 10 mg of cloves and 10 mg of cloves. Figure 1 Figure 2

Claims (1)

[Scope of Claims] 1. An oral composition containing a powder or water extract of a crude drug selected from the group consisting of mentha, thyme, ginger, amacha, and clove, and a clathrate, and adjusted to pH 6 to 11. thing. 2. The composition according to claim 1, further comprising a dental plaque degrading enzyme dextranase.