JP4336272B2 - Tobacco odor deodorant, food and drink containing the same, deodorant composition, production method and use thereof - Google Patents

Description

The present invention contains a deodorant for tobacco odor, which contains as an active ingredient an extract obtained from boswellia carteri, motherwort (Leonurus cardiaca), akamegashiwa (Malltus japonicus ) and myrtle (Myrtus communis ) The present invention relates to a product and a deodorant composition, and a production method and a use method thereof.

  Tobacco bad breath caused by smoking and tobacco odor adhering to clothes are a bad smell not only for non-smokers but also for smokers. Due to the recent improvement in cleanliness, the need to deodorize tobacco odors is increasing.

  As a method to deodorize tobacco odor, masking reaction to prevent odor from being felt with strong scent, chemical reaction to change odor molecular structure to make it odorless or non-volatile, adsorption reaction of odor, inclusion reaction of odor, medium Sum reaction is currently adopted.

  Deodorizers that contain essential oils such as eucalyptus as an active ingredient have already been proposed in anticipation of a masking reaction (see, for example, Patent Document 1), but these essential oils have a unique strong fragrance, and therefore products with various flavors. Use is limited in application to Therefore, development of a highly practical deodorant by a method other than the masking effect is desired.

  On the other hand, cyclodextrin has an effect of including a malodorous substance in its molecule, but its action is limited to a malodorous substance having a size suitable for inclusion or a structure that can be easily included (see, for example, Non-Patent Document 1). . Accordingly, when the malodorous substance is composed of more than 2,000 components such as tobacco odor, the deodorizing effect by cyclodextrin is insufficient.

  Moreover, since plant extracts such as oyster leaves have a deodorizing effect on nicotine and trimethylamine (see, for example, Patent Document 2), they are expected to have a deodorizing effect on tobacco odor. It is not a satisfactory deodorizing effect. In light of the above, development of a deodorant that is highly safe and has a strong deodorizing effect against tobacco odor is now strongly desired.

In order to solve the above-mentioned problems, the present inventors searched for a plant extract having an effective neutralization reaction against tobacco odor, and made bolus (Boswellia carteri), mother wort (Leonurus cardiaca), and red-spotted (Mallotus japonicus ). And the extract obtained from Myrtus communis was found to have a strong deodorizing effect. The neutralization reaction does not cover the odor with a strong scent like masking, but reduces the odor (tobacco odor) itself. There are no reports on the deodorizing effect of Mother Wort, Angelica and Myrtle. It is disclosed that the fragrance | flavor containing the essential oil component of frankincense has a masking effect with respect to a foot odor (for example, refer patent document 3). However, the foot odor component is a lower fatty acid such as isovaleric acid, and the tobacco odor is composed of more than 2,000 components including nitrogen-containing compounds such as nicotine and its decomposition products. Both compositions are completely different. Therefore, it has not been clarified that frankincense shows a deodorizing effect on tobacco odor. Regarding the red wrinkles, the removal effect of methyl mercaptan, which is a thiol compound, has been clarified (see, for example, Patent Document 4). However, methyl mercaptan is contained in the tobacco smoke component, but its amount is small and it is one of the components exceeding 2,000. Odor reduction cannot be expected and has not been confirmed. Therefore, the tobacco odor deodorizing effect of these plant extracts has been clarified for the first time by the present invention.

Monthly Food Chemical, 1989, No.11, p32-44 JP-A-9-103473 JP 60-261458 A JP-A-6-92831 JP-A-9-164189

  The present invention is a deodorant containing, as an active ingredient, a highly safe natural plant extract that can be used safely for food and drink, and it is against a tobacco odor that is a complex odor without depending on a masking reaction. It is providing the deodorizer which shows a high effect, the food-drinks containing this, and a deodorant composition, its manufacturing method, and its usage.

In order to solve the above problems, the present inventors have focused on natural medicine extracts such as herbal medicines and herbs that have no side effects and are highly safe and have been used since ancient times, and find materials that exhibit a deodorizing effect on tobacco odor. Therefore, a deodorization test using tobacco odor as a bad odor source was conducted. As a result, it was found that an extract obtained from frankincense (Boswellia carteri), motherwort (Leonurus cardiaca), red mulberry (Malltus japonicus ) and myrtle (Myrtus communis ) has tobacco odor deodorizing activity by neutralization reaction, Completed the invention.

In addition, one or two or more kinds of plants selected from the group consisting of frankincense (Boswellia carteri), mother wort (Leonurus cardiaca), red mulberry (Malltus japonicus ) and myrtle (Myrtus communis ) are pulverized alone or in a mixed state, Obtained by extracting the pulverized product alone or in a mixed state at 50 to 80 ° C. for 1 to 5 hours with one or more mixed solvents selected from the group consisting of water, lower alcohol and acetone Tobacco obtained by filtering the extract alone or in a mixed state, and concentrating or lyophilizing the obtained filtrate alone or in a mixed state under reduced pressure, and obtaining the resulting extract alone or mixed If it is a manufacturing method of the deodorant with respect to an odor, the said deodorizer may be manufactured. It was issued.

  It has also been found that the above deodorant can be used by being contained in powders, tablets, troches, gargles, toothpastes, mouth odor sprays or deodorant sprays.

  The deodorizer of this invention has the effect | action which deodorizes tobacco odor by neutralization reaction. Therefore, it is possible to reduce the tobacco odor, which is a complex odor, by including the deodorant in various flavor compositions and foods and beverages, orally ingesting it, or spraying it on exhaled air. .

The present invention is described in detail below. The raw materials of the present invention are bolus (Boswellia carteri), mother wort (Leonurus cardiaca), red wrinkle (Mallotus japonicus), angelica (Angelica archagenica) and myrtle (myrtus communis, whole leaves, myrtus communis, their leaves) Resin, etc. can be used, but for Mother Wort and Myrtle, especially its leaves, for frankincense, especially for the gelatinous resin obtained from the stem bark, for Akamegasiwa, especially for its bark, especially for Angelica It is desirable to use that root.

  In order to obtain the extract of the present invention, first, the plant-derived raw material is pulverized by an appropriate pulverizing means. The method of obtaining the extract of the present invention from the pulverized product is conventionally performed by adding one or more mixed solvents of water, methanol, ethanol, lower alcohols such as n-propanol, and organic solvents such as acetone. The plant extract of the present invention can be obtained by the existing extraction method. However, considering that the product of the present invention is used as a deodorant composition that is taken orally by humans or blown into exhaled air, or a food or drink, the extraction solvent is water and water from the viewpoint of safety. It is preferred to use a combination with ethanol.

  As extraction conditions, extraction can be carried out at any of high temperature, room temperature, and low temperature, but preferably at 50 to 80 ° C. for about 1 to 5 hours. The obtained extract can be used after being filtered and further concentrated or lyophilized under reduced pressure. In addition, those obtained by fractionating and purifying these extracts using an organic solvent, column chromatography, or the like can also be used.

  Further, since the deodorant of the present invention is excellent in fragrance, taste and safety, for example, powders, tablets, emollients, toothpastes, deodorant sprays and other deodorant compositions, chewing gum, candy, It can be blended into foods and drinks such as confectionery such as tablet confectionery, gummy jelly and chocolate, sorbet and beverage, and used on a daily basis. Moreover, it is also possible to use for removing the tobacco odor adhering to clothes etc. by spraying the deodorizer of this invention.

  Moreover, the deodorizer of this invention can recognize a synergistic effect with them by further containing common deodorizers, such as a cyclodextrin. The mixing ratio of cyclodextrin to the deodorant of the present invention is preferably 1: 100 to 100: 1, more preferably 1:10 to 10: 1.

  The addition amount of the deodorant of the present invention is about 0.001% by weight or more, preferably about 0.01% by weight or more in the dry extract state with respect to the food or drink or the deodorant composition. Furthermore, in the case of food / beverage products, it is preferable to add so that the ratio is about 0.001 to 5% by weight, preferably about 0.01 to 1% by weight, particularly in view of palatability.

  Plants that are the raw materials of the present invention, including Angelica and Myrtle, have been used for a long time as herbal medicines, food materials, herbal teas and natural additives, and these extracts and foods and drinks containing these extracts There is no problem with the safety of the product and the deodorant composition.

  EXAMPLES Hereinafter, although an Example is given and this invention product is demonstrated further in detail, the range of this invention product is not restrict | limited by them.

  100 ml of water is added to 10 g of the dry powder of dairy resin, and a reflux condenser is attached, followed by extraction while refluxing at 80 ° C. for 1 hour. The obtained extract was collected by filtration and freeze-dried to obtain 3.3 g of the extract. In the same manner, mother wort, red mulberry, angelica, myrtle, green tea and oyster were extracted using water, and the extract was concentrated or lyophilized to obtain an extract. The yield of the extract is shown in Table 3.

  Add 100 ml of 50% ethanol to 10 g of dried mother wort powder, attach a reflux condenser, and extract while refluxing at 80 ° C. for 1 hour. The obtained extract was filtered off, the solvent was removed, and lyophilized to obtain 2.8 g of the extract. Similarly, extraction was obtained by extracting 50% ethanol with frankincense, red-crowned wrinkle, angelica, myrtle, green tea and oyster, and concentrating or lyophilizing the extract. The yield of the extract is shown in Table 3.

  100 g of 50% acetone is added to 10 g of dry powder of Akamegashi bark that has been subjected to de-essential oil treatment, and a reflux condenser is attached and extraction is performed while refluxing for 1 hour. The obtained extract was collected by filtration, the solvent was removed, and freeze-dried to obtain 2.1 g of the extract. In the same manner, frankincense, mother wort, angelica and myrtle were extracted with 50% acetone, and the extract was concentrated or lyophilized to obtain an extract. The yield of the extract is shown in Table 3.

  100 g of 50% n-propanol is added to 10 g of dried angelica root that has been subjected to de-essential oil treatment, and a reflux condenser is attached and extraction is performed while refluxing for 1 hour. The obtained extract was collected by filtration, the solvent was removed, and freeze-dried to obtain 3.3 g of the extract.

  Similarly, frankincense, mother wort, red mulberry and myrtle were extracted using 50% n-propanol, and the extract was concentrated or lyophilized to obtain an extract. The yield of the extract is shown in Table 3.

  Add 100 ml of 50% methanol to 10 g of Myrtle leaf powder, attach a reflux condenser and extract with reflux for 1 hour. The obtained extract was collected by filtration, the solvent was removed, and freeze-dried to obtain 2.6 g of extract. In the same manner, extraction was obtained by extracting 50% methanol with respect to frankincense, mother wort, red wrinkle and angelica, and concentrating or lyophilizing the extract. The yield of the extract is shown in Table 3.

Comparative Example 1

  Essential oil was obtained from 10 g of eucalyptus leaf powder using a steam distillation apparatus.

  Example 6 was prepared by weighing and mixing 1.5 mg of the fragrance resin water extract and 1.5 mg of the mother wort leaf water extract.

  Example 7 was prepared by weighing and mixing 1.5 mg of 50% ethanol extract of mother wort leaves and 1.5 mg of 50% ethanol extract of Akamegawashi bark.

  Angelica root 50% acetone extract 1.5mg and milk perfume resin water extract 1.5mg were weighed and mixed to give Example 8.

  Example 9 was prepared by weighing and mixing 1.5 mg of Myrtle leaf 50% methanol extract and 1.5 mg of Angelica root 50% propanol extract.

Comparative Example 2

  Cyclodextrin 10 mg was weighed and used as Comparative Example 2.

  10 mg of cyclodextrin and 3 mg of the milk resin water extract were weighed and mixed to obtain Example 10.

  Cyclodextrin 10 mg and mother wort leaf 50% ethanol extract 3 mg were weighed and mixed to give Example 11.

  10 mg of cyclodextrin and 3 mg of angelica root 50% acetone extract were weighed and mixed to obtain Example 12.

Test example

1) Preparation of tobacco odor standard solution After packing 400 mg of quartz wool (A grade: for GC device) into a glass tube (inner diameter 23 mm × 9 cm) and passing tobacco smoke (for 5 mild sevens), quartz wool or glass Tobacco spider adhering to the tube was dissolved in ethanol. This solution was distilled off with ethanol using an evaporator to obtain a tobacco crab extract. This extract was dissolved in 100 ml of pure water and the insoluble matter was filtered off with filter paper (No. 2), and the filtrate was used as a tobacco odor standard solution.

2) Reaction and evaluation 1.9 ml of water, 0.1 ml of tobacco odor standard solution and 3 mg of the deodorant obtained in the examples or comparative examples were placed in a vial, covered, and then statically kept at 37 ° C. for 30 minutes. The deodorant of the present invention obtained in the examples or the deodorant of the comparative example was reacted with the tobacco odor standard solution. For control purposes, only 1.9 ml of water and 0.1 ml of tobacco odor standard solution were treated in the same manner. After the reaction, the headspace gas in the vial was sensorially evaluated by five panelists. The smell of the content for a control | contrast was sniffed first, and the sensory evaluation value was made into the control value of tobacco odor and odor intensity | strength. Subsequently, the contents for material evaluation were smelled by relative comparison with the control value, and the sensory evaluation value was used as the test value.

  As shown in Table 1 and Table 2, the sensory evaluation values are the cigarette odor intensity (0-5: 6 level) and odor intensity (0-3: 4 level), and averaged the values of 5 panelists. Digitized. The intensity of tobacco odor indicates the intensity of smell peculiar to tobacco, and the intensity of odor indicates the intensity of odor including an odor derived from an extract other than tobacco odor. For example, an essential oil having a masking effect has a low tobacco odor intensity and a high odor intensity, and a material having a neutralizing action has a low tobacco odor intensity and an odor intensity. The results are shown in Tables 3, 4 and 5.

  As shown in Table 3, in the water extract (Example 1), frankincense, mother wort, akamegashi wrinkle, angelica and myrtle have a tobacco odor compared to green tea, which is generally known for its deodorizing effect, and oyster leaves that are effective for tobacco odor. At the same time, it showed an excellent deodorizing effect that reduced the odor intensity. Also in 50% ethanol extract (Example 2), Akamega wrinkles, frankincense, mother wort, angelica and myrtle are generally known to have a deodorizing effect, reducing the odor of tobacco compared to green tea and oyster leaves effective for tobacco odor. At the same time, it showed an excellent deodorizing effect that reduced the odor intensity. Eucalyptus essential oil (Comparative Example 1), which has a known masking effect, reduced tobacco odor, but had strong odor intensity because it had a scent specific to essential oil. Also in the examples using other extraction solvents, deodorizing effects of frankincense, mother wort, akamegashi wrinkle, angelica and myrtle were confirmed.

  As shown in Table 4, regarding the deodorizing effect when two kinds of plant extracts are combined, the deodorizing effect is the same as in the case of one kind of plant extract in any of Examples 6 to 9. Admitted.

  As shown in Table 5, with respect to the deodorizing effect when cyclodextrin alone or a plant extract and cyclodextrin are used in combination, the deodorizing effect is improved in any of Examples 10 to 12 as compared with cyclodextrin alone. The plant extract was positive for the deodorizing effect of cyclodextrin.

  From the above results, the deodorant of the present invention is an excellent deodorant for tobacco odor due to neutralization reaction, and since it does not have a unique strong fragrance like essential oil, it can be applied to products with various flavors. is there. Moreover, the plant used as the raw material of the product of the present invention has been used for a long time as a food and drink material, herbal tea, and natural additive, and there is no problem with respect to its safety.

  Using the extract obtained in Example 1, a powder was prepared according to the following formulation.

Lactose 79.0 parts potato starch 20.0 parts
1.0 parts of fragrance resin water extract

  Using the extract obtained in Example 1, tablets were prepared according to the following formulation.

D-mannitol 44.0 parts Lactose 40.0 parts Crystalline cellulose 10.0 parts Hydroxypropyl cellulose 5.0 parts
Mother Wort Leaf Extract 1.0 part

  Using the extract obtained in Example 1, a lozenge was prepared according to the following formulation.

Glucose 72.3 parts Lactose 19.0 parts Gum arabic 6.0 parts Fragrance 1.0 parts Sodium monofluorophosphate 0.7 parts
Akamegawashi bark water extract 1.0 part

  Using the extract obtained in Example 2, a gargle was prepared according to the following formulation.

Ethanol 2.0 parts Fragrance 1.0 parts Saccharin 0.05 parts Chlorhexidine hydrochloride 0.01 parts Akamegawashi bark 50% ethanol extract 0.5 parts
96.44 parts of water

  Using the extract obtained in Example 5, toothpaste was prepared according to the following formulation.

Calcium carbonate 50.0 parts Glycerin 20.0 parts Carboxymethyl cellulose 2.0 parts Sodium lauryl sulfate 2.0 parts Fragrance 1.0 part Saccharin 0.1 part Myrtle leaf 50% methanol extract 1.0 part Chlorhexidine 0.01 Part
23.9 parts of water

  Using the extract obtained in Example 1, a bad breath spray was prepared according to the following formulation.

Ethanol 10.0 parts Glycerin 5.0 parts Milk flavor resin water extract 1.0 part Fragrance 0.05 part Coloring 0.001 part
83.949 parts of water

  Using the extract obtained in Example 4, a deodorant spray was prepared according to the following formulation.

Ethanol 49.5 parts Angelica root 50% n-propanol extract 0.5 parts
50.0 parts of water

  This was filled with an injection gas (nitrogen gas) into an aerosol container to prepare a deodorant spray.

  Using the extract obtained in Example 1, chewing gum was prepared according to the following formulation.

Gum base 20.0 parts Sugar 55.0 parts Glucose 15.0 parts Minamata 9.0 parts Fragrance 0.5 parts
Mother Wort Leaf Extract 0.5 parts

  Using the extract obtained in Example 1, candy was prepared according to the following formulation.

Sugar 50.0 parts Minamata 34.0 parts Fragrance 0.5 parts Akamegawashi bark water extract 0.5 parts
15.0 parts of water

  Using the extract obtained in Example 3, tablet confectionery was prepared according to the following formulation.

Sugar 76.4 parts Glucose 19.0 parts Sucrose fatty acid ester 0.2 parts Fragrance 0.2 parts Mother wort leaf 50% acetone extract 0.1 parts
4.1 parts of water

  Using the extract obtained in Example 1, gummy jelly was prepared according to the following formulation.

Gelatin 60.0 parts Chickenpox 23.0 parts Sugar 8.5 parts Vegetable oil 4.5 parts Mannitol 2.95 parts Lemon juice 1.0 part
Nylon resin water extract 0.05 parts

  Using the extract obtained in Example 5, chocolate was prepared according to the following formulation.

Powdered sugar 40.8 parts Cocoa bitter 20.0 parts Whole milk powder 20.0 parts Cocoa butter 17.0 parts Mannitol 1.0 parts Myrtle leaf 50% methanol extract 1.0 parts
Fragrance 0.2 parts

  Using the extract obtained in Example 1, sherbet was prepared according to the following formulation.

Orange juice 25.0 parts Sugar 25.0 parts Egg white 10.0 parts Akamegasiwa bark water extract 2.0 parts
38.0 parts of water

Claims (7)

Frankincense (Boswellia carterii), Motherwort (Leonurus cardiaca), for Mallotus japonicus (Mallotus japonicus), Ma Toru (Myrtus communis) 1 kind or tobacco odors as an active ingredient more than one plant extract is selected from the group consisting of Deodorants.   Food / beverage products containing the deodorizer with respect to the tobacco odor of Claim 1.   The food or drink according to claim 2, comprising 0.001 to 5% by weight of a deodorant.   A deodorant composition comprising a deodorant for tobacco odor according to claim 1.   The deodorant composition according to claim 4, comprising 0.001 to 5% by weight of a deodorant. Frankincense (Boswellia carterii), Motherwort (Leonurus cardiaca), triturated with Mallotus japonicus (Mallotus japonicus), alone one or more plants selected from the group consisting of Ma Toru (Myrtus communis) or mixed state,
Extracting the pulverized product alone or in a mixed state with one or two or more mixed solvents selected from the group consisting of water, lower alcohol and acetone at 50 to 80 ° C. for 1 to 5 hours,
Filter the resulting extract alone or in a mixed state, and
The obtained filtrate is concentrated or freeze-dried under reduced pressure alone or in a mixed state,
The manufacturing method of the deodorizer with respect to the tobacco odor obtained by individual or mixing the obtained extract. The use method of the deodorizer by which the deodorizer of Claim 1 is contained and used for a powder, a tablet, a troche, a mouthwash, a toothpaste, a bad breath spray liquid, or a deodorant spray liquid.