JP6920803B2 - Oral composition - Google Patents

Description

The present invention relates to oral compositions. More specifically, the present invention relates to an oral composition for deodorizing tobacco odor that can effectively deodorize tobacco odor.

In recent years, against the background of increasing demand for oral care, especially halitosis care, various oral compositions for oral care containing deodorant components have been developed and put on the market. In addition, halitosis includes tobacco odor, garlic odor, alcohol odor, etc. depending on the cause of the odor, and the effective deodorant component changes depending on the cause of the odor. Deodorant components are selected and blended according to the cause of the target odor.

In addition, smokers are becoming more aware of care for tobacco odor, and it is desired to develop an oral composition having a high deodorizing effect on tobacco odor. Conventionally, various studies have been conducted on oral care products for tobacco odor. For example, in Patent Document 1, foods and drinks containing an extract of one or more plants selected from the group consisting of frankincense, motherwort, Mallotus japonicus, angelica, and myrtle as an active ingredient reduce tobacco odor. It is disclosed to get. Further, Patent Document 2 describes a tobacco odor deodorant composition containing a mandarina orange essential oil or a mandarina orange essential oil fraction from which terpene hydrocarbons have been substantially removed, and a tobacco odor deodorant comprising a carrier supporting the composition. It is disclosed that the tobacco odor can be masked by blending the agent into foods and drinks and oral compositions.

However, the techniques of Patent Documents 1 and 2 may not be able to cope with the diversification of oral compositions in recent years due to restrictions on the formulation. Therefore, it is desired to develop a new formulation for an oral composition capable of deodorizing tobacco odor.

Japanese Unexamined Patent Publication No. 2006-55055 JP-A-2002-143285

An object of the present invention is to provide an oral composition for deodorizing tobacco odor, which can effectively deodorize tobacco odor.

As a result of diligent studies to solve the above problems, the present inventor has found that medium-chain fatty acid triglyceride has a high deodorizing effect on tobacco odor, and an oral composition containing medium-chain fatty acid triglyceride is used for deodorizing tobacco odor. Found that it can be used for. Furthermore, the present inventor has found that the oral composition containing a medium-chain fatty acid triglyceride and a dipeptide sweetener, and the oral composition containing a medium-chain fatty acid triglyceride, a dipeptide sweetener, and menthol have a significantly improved deodorizing effect on tobacco odor. I also found. The present invention has been completed by further studies based on these findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. An oral composition for deodorizing tobacco odors, which contains a medium-chain fatty acid triglyceride.
Item 2. Item 2. The oral composition for deodorizing tobacco odor according to Item 1, further containing a long-chain fatty acid triglyceride.
Item 3. Item 2. The oral composition for deodorizing tobacco odor according to Item 2, which further contains a dipeptide sweetener.
Item 4. The oral composition for deodorizing tobacco odor according to Item 2 or 3, further containing menthol.
Item 5. Item 8. The oral composition for deodorizing tobacco odor according to any one of Items 1 to 4, wherein the content of the medium-chain fatty acid triglyceride is 50 to 99.85% by weight.
Item 6. A soft capsule comprising the oral composition according to any one of Items 1 to 5.

The oral composition of the present invention has an excellent deodorizing effect on tobacco odor and can be used for deodorizing tobacco odor, and is therefore effective as an oral care product for smokers.

The oral composition of the present invention is used for deodorizing tobacco odors and is characterized by containing a medium chain fatty acid triglyceride. Hereinafter, the oral composition of the present invention will be described in detail.
[Ingredients]
-Medium-chain fatty acid triglyceride The oral composition of the present invention contains a medium-chain fatty acid triglyceride in order to deodorize the odor of tobacco.

The medium-chain fatty acid triglyceride is a compound having a structure in which three medium-chain fatty acids are ester-bonded to glycerol. In the present invention, the medium-chain fatty acid constituting the medium-chain fatty acid triglyceride may be either a saturated fatty acid or an unsaturated fatty acid, but a saturated fatty acid is preferable. The medium-chain fatty acid constituting the medium-chain fatty acid triglyceride may have 6 to 12 carbon atoms, and specific examples thereof include caproic acid, caprylic acid, capric acid, and lauric acid. From the viewpoint of further improving the deodorizing effect of tobacco odor, the carbon number is more preferably 8 to 12, and even more preferably 8 to 10.

In the medium-chain fatty acid triglyceride used in the present invention, the three medium-chain fatty acids contained in one molecule may be the same medium-chain fatty acid, respectively, and may be a combination of two or three types of medium-chain fatty acids. You may.

Among the medium-chain fatty acid triglycerides, a medium-chain fatty acid triglyceride having at least one of caprylic acid, capric acid and lauric acid is preferable from the viewpoint of further improving the deodorizing effect of tobacco odor, and caprylic acid or caprylic acid is preferable. Medium-chain triglycerides having at least one of the acids are more preferred, and medium-chain triglycerides having caprylic acid and capric acid are even more preferred.

The medium-chain fatty acid triglyceride having capric acid and capric acid is a triglyceride also called tri (capric acid / capric acid) glyceryl, and is a triester of a mixed fatty acid of capric acid and capric acid and glycerin, or It is a mixed triglyceride of a triester of capric acid and glycerin and a triester of capric acid and glycerin. In the medium-chain fatty acid triglyceride having caprylic acid and capric acid, the ratio of caprylic acid and capric acid to the total weight of the constituent medium-chain fatty acids is not particularly limited, but for example, caprylic acid is 30 to 98% by weight. It is preferably 80 to 98% by weight, and caprylic acid is 1 to 35% by weight, preferably 1 to 20% by weight. Further, the medium-chain fatty acid triglyceride having caprylic acid and capric acid may contain lauric acid as a constituent medium-chain fatty acid. When lauric acid is contained as a constituent medium-chain fatty acid in the medium-chain fatty acid triglyceride having caprylic acid and capric acid, the ratio of lauric acid to the total weight of the constituent medium-chain fatty acids is not particularly limited, but is, for example, 0. .1 to 21% by weight, preferably 0.1 to 1% by weight, but it is desirable that the proportion of lauric acid is small. Of course, lauric acid may not be contained as a constituent medium-chain fatty acid.

The content of the medium-chain fatty acid triglyceride in the oral composition of the present invention should be appropriately set according to the content of other components to be blended in the oral composition, the form of the oral composition, the amount of intake per dose, and the like. However, for example, 50% by weight or more can be mentioned. The content of the medium-chain fatty acid triglyceride in the oral composition of the present invention is more specifically 50 to 100% by weight, preferably 50 to 99.85% by weight, more preferably 50 to 99% by weight, still more preferably. 50 to 95% by weight, particularly preferably 50 to 85% by weight.

-Long-chain fatty acid triglyceride The oral composition of the present invention may contain a long-chain fatty acid triglyceride in order to further improve the deodorizing effect of tobacco odor. Long-chain fatty acid triglyceride alone does not show an effective deodorizing effect on tobacco odor, but the combined use of medium-chain fatty acid triglyceride and long-chain fatty acid triglyceride can dramatically improve the deodorizing effect on tobacco odor. ..

The long-chain fatty acid triglyceride is a compound having a structure in which three long-chain fatty acids are ester-bonded to glycerol. In the present invention, the long-chain fatty acid constituting the long-chain fatty acid triglyceride may be either a saturated fatty acid or an unsaturated fatty acid. The long-chain fatty acid constituting the long-chain fatty acid triglyceride may have 14 or more carbon atoms, preferably 14 to 24 carbon atoms, more preferably 16 to 22 carbon atoms, and further preferably 16 to 18 carbon atoms. Frequently, specific examples include mistylic acid, palmitic acid, palmitic acid, stearic acid, oleic acid, vaccenic acid, linoleic acid, arachidic acid, arachidonic acid, bechenic acid, lignoceric acid and the like.

In the long-chain fatty acid triglyceride used in the present invention, the three long-chain fatty acids contained in one molecule may be the same long-chain fatty acid, respectively, and may be a combination of two or three types of long-chain fatty acids. You may.

Among the long-chain fatty acid triglycerides, a long-chain fatty acid triglyceride having at least one of palmitic acid, oleic acid, and linoleic acid is preferable from the viewpoint of further improving the deodorizing effect of tobacco odor, and palmitin. Long-chain fatty acid triglycerides having acids, oleic acid, and linoleic acid are more preferred.

The long-chain fatty acid triglycerides having palmitic acid, oleic acid, and linoleic acid are (i) a triester of three mixed fatty acids of palmitic acid, oleic acid, and linoleic acid and glycerin, and (ii) palmitin. Triester of two mixed fatty acids selected from acid, oleic acid, and linoleic acid and glycerin, and among palmitic acid, oleic acid, and linoleic acid, fatty acids and glycerin not contained in the mixed fatty acids. (Iii) A mixed triglyceride of a triester of oleic acid and glycerin, a triester of oleic acid and glycerin, and a mixed triglyceride of a triester of linoleic acid and glycerin.

When the oral composition of the present invention contains a long-chain fatty acid triglyceride, the content thereof may be appropriately set according to the form of the oral composition, the amount of intake per dose, and the like. 05 to 50% by weight, preferably 0.1 to 40% by weight, more preferably 0.1 to 30% by weight.

When the oral composition of the present invention contains a long-chain fatty acid triglyceride, the ratio of the long-chain fatty acid triglyceride to the medium-chain fatty acid triglyceride is not particularly limited. The chain fatty acid triglyceride is 0.05 to 100 parts by weight, preferably 0.1 to 100 parts by weight.

-Dipeptide sweetener The oral composition of the present invention may contain a dipeptide sweetener together with a long-chain fatty acid triglyceride in order to further improve the deodorizing effect of tobacco odor. Dipeptide sweeteners alone do not show an effective deodorizing effect on tobacco odors, but the combination of medium-chain fatty acid triglycerides, long-chain fatty acid triglycerides, and dipeptide sweeteners can further improve the deodorizing effect on tobacco odors. Can be done.

A dipeptide sweetener is a compound in which two amino acids are bound by a peptide bond to exhibit sweetness.

The type of dipeptide sweetener used in the present invention is not particularly limited, and examples thereof include aspartame and advantame. In the present invention, the dipeptide sweetener may be used alone or in combination of two or more.
Among these dipeptide sweeteners, aspartame is preferable from the viewpoint of further improving the deodorizing effect of tobacco odor.

When the dipeptide sweetener is contained in the oral composition of the present invention, the content thereof may be appropriately set according to the form of the oral composition, the amount of intake per dose, and the like. For example, 0.15. -5% by weight, preferably 0.5-5% by weight, more preferably 1-3% by weight.

When the dipeptide sweetener is contained in the oral composition of the present invention, the ratio of the dipeptide sweetener to the medium-chain fatty acid triglyceride is not particularly limited, but for example, the dipeptide sweetener per 100 parts by weight of the medium-chain fatty acid triglyceride. Is 5 to 60 parts by weight, preferably 11 to 43 parts by weight.

-Menthol The oral composition of the present invention may contain menthol together with a long-chain fatty acid triglyceride in order to further improve the deodorizing effect of tobacco odor. Menthol alone does not show an effective deodorizing effect on tobacco odor, but the combination of medium-chain fatty acid triglyceride, long-chain fatty acid triglyceride, and menthol can further improve the deodorizing effect on tobacco odor. In particular, when it contains a medium-chain fatty acid triglyceride, a long-chain fatty acid triglyceride, a dipeptide sweetener, and menthol, it becomes possible to exert an excellent deodorizing effect of tobacco odor.

The menthol used in the present invention may be d-form, dl-form, or l-form, but d-form and dl-form are preferable. Further, in the present invention, menthol may be used in the state of an essential oil containing menthol. The essential oil containing menthol can be appropriately selected from known ones and used, and examples thereof include peppermint oil and peppermint oil. The description regarding the content and ratio of the menthol component in the present specification is a value converted into the amount of menthol contained in the essential oil when the essential oil containing menthol is used.

When menthol is contained in the oral composition of the present invention, the content thereof may be appropriately set according to the form of the oral composition, the amount of intake per dose, and the like, and is, for example, 1 to 30% by weight. , Preferably 5 to 20% by weight, more preferably 10 to 20% by weight.

-Other additive components The oral composition of the present invention may contain other nutritional components and pharmacological components in addition to the above-mentioned components, if necessary. Such nutritional components and pharmacological components are not particularly limited as long as they can be used in foods and drinks and pharmaceuticals, and for example, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin A, and vitamin D. , Vitamin E, Vitamin K, Niacin, Pantothenic acid, Folic acid, Biotin, Ricopen and other vitamins; Vitamin hydrochloride, Carnitine chloride, Betanecol chloride and other stomachic agents; Minerals such as calcium, sulfur, magnesium, zinc, selenium and iron; Proteins such as soybean protein, egg white powder, milky protein; amino acids such as glycine, alanine, arginine, aspartic acid, cystine, phenylalanine, taurine, tryptophan; fatty acids such as linoleic acid, γ-linolenic acid, α-linolenic acid; Caramel pigment, cutinashi pigment, anthocyanin pigment, anato pigment, paprika pigment, red flower pigment, red koji pigment, flavonoid pigment, cochineal pigment, amaranth, erythrosin, alla red AC, new coxin, floxin, rose bengal, acid red, tartradin, sun Pigments such as set yellow FCF, fast green FCF, brilliant blue FCF, and indigo carmine; fragrances such as flavors and essences of various fruits; citric acid and its salts, malic acid and its salts, tartrate acid and its salts, acetic acid and its salts, Lactic acid and its salt, salt, glutamic acid and its salt, mirin, vinegar, natural fruit juice, plant extract, cuts such as fruits and seafood, or seasonings such as powdered products; mushrooms such as agarix, shiitake extract, reishi, and yamabushitake Or an extract thereof; other functional materials such as dietary fiber, royal jelly, propolis, honey, chondroitin sulfate, glucosamine, ceramide, hyaluronic acid and the like can be mentioned. These additive components may be used alone or in combination of two or more. The content of these additive components is appropriately set according to the type of additive component to be used, the form of the oral composition, and the like.

Further, the oral composition of the present invention may contain a base, additives and the like, if necessary, in order to prepare it into a desired pharmaceutical form. Such bases and additives are not particularly limited as long as they can be used in foods and pharmaceuticals, and are, for example, water, fats and oils, waxes, hydrocarbons, fatty acids, higher alcohols, and esters. , Water-soluble polymers, surfactants, metal soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, UV inhibitors, preservatives, fragrances, powders, thickeners, pigments, Examples include chelating agents. These additive components may be used alone or in combination of two or more. The contents of these bases and additives are appropriately set according to the type of additive component to be used, the form of the oral composition, and the like.

[Production method]
The oral composition of the present invention can be produced by mixing a medium-chain fatty acid triglyceride and other components contained as necessary by a known formulation method according to the formulation form.

Further, when the oral composition of the present invention contains a dipeptide sweetener, the dipeptide sweetener has low compatibility with the long-chain fatty acid triglyceride. Therefore, it is desirable to prepare the dipeptide sweetener in a suspended state. ..

The method for suspending the dipeptide sweetener is not particularly limited, and examples thereof include a method of performing a stirring treatment such as mechanical stirring or ultrasonic stirring under heating conditions. The conditions during the stirring treatment are not particularly limited, but for example, 40 to 100 ° C., preferably 45 to 90 ° C., more preferably 60 to 90 ° C., still more preferably 70 to 90 ° C., particularly preferably 80 to 90 ° C. Under the temperature condition of ° C., 30 to 300 minutes, preferably 40 to 300 minutes, more preferably 60 to 270 minutes can be mentioned.

[form]
The form of the oral composition of the present invention is not particularly limited as long as it contains the above-mentioned components and can be orally ingested, and may be formulated into, for example, a soft capsule, a liquid, a gel or the like. Among these forms, soft capsules are preferable.

When the oral composition of the present invention is formulated as a soft capsule, the oral composition of the present invention may be encapsulated with a soft capsule film generally used in the soft capsule.

The soft capsule film may be any as long as it can form a film and contains an edible water-soluble polymer as a base. Specific examples of the base of the soft capsule film include gelatin, agar, xanthan gum, karaya gum, locust bean gum, gum arabic, purulan, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium alginate and the like. These bases may be used alone or in combination of two or more. Among these bases, gelatin is preferable.

The content of the base in the soft capsule film is not particularly limited, and examples thereof include 40 to 90% by weight, preferably 50 to 80% by weight, and more preferably 55 to 75% by weight.

In addition to the base, the soft capsule film may contain a plasticizer, if necessary, in order to promote the plasticization of the base. Examples of the plasticizer include glycerin, propylene glycol, sorbitol and the like. These plasticizers may be used alone or in combination of two or more.

When the soft capsule film contains a plasticizer, the content thereof may be appropriately set according to the type of the plasticizer to be used, for example, 5 to 50% by weight, preferably 10 to 40% by weight, and more. 20 to 30% by weight is preferable.

Further, the soft capsule film may contain water, emulsifiers, lower alcohols, pH adjusters, buffers, antioxidants, preservatives, etc., if necessary, for the purpose of improving the stability of the film, seasoning, adjusting solubility, etc. Additives such as acidulants, bitterness agents, flavors, powders, thickeners and chelating agents may be included. These additives may be used alone or in combination of two or more.

The method for encapsulating the oral composition of the present invention with a soft capsule film may be any known method for producing a soft capsule, and examples thereof include a rotary soft encapsulation method and a seamless encapsulation method.

[Use / Intake]
The oral composition of the present invention is used for deodorizing tobacco odor. The timing of ingestion of the oral composition of the present invention is not particularly limited and may be before or after smoking, but preferably after smoking.

The intake of the oral composition of the present invention is not particularly limited, but may be, for example, an amount such that the intake of medium-chain fatty acid triglyceride is about 80 to 160 mg at a time.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.

Test Example An oral composition having the composition shown in Table 1 (all liquid except for Reference Example 2) was prepared. Specifically, for Examples 1 to 8, an oral composition was prepared by mixing a predetermined amount of each component shown in Table 1. For the oral compositions of Examples 9 and 10, after mixing a predetermined amount of components other than aspartame, a predetermined amount of aspartame was further added, and a tornado stirrer (“Tornado PM-202”, “Tornado PM-202”, An oral composition was obtained by mechanically stirring the mixture with AS ONE Corporation (rotation speed 500 rpm) to form a suspension state.

The deodorizing effect of the obtained oral composition on tobacco odor was evaluated by the following method. 20 μl of each oral composition was added to 180 μl of 2-methoxyphenol and mixed to obtain a mixed solution. The odor paper (manufactured by Daiichi Yakuhin Sangyo Co., Ltd.) cut to a length of 5 cm was dipped in this mixed solution and allowed to permeate for 30 minutes. Then, the volatilization amount of 2-methoxyphenol was measured by the headspace GC / MS method using the odor paper impregnated with the mixed solution. In this measurement system, when each oral composition is added, the amount of 2-methoxyphenol volatilized is reduced as compared with the case where the oral composition is not added, the effect of deodorizing the tobacco odor is obtained. The smaller the volatilization amount of the 2-methoxyphenol, the higher the deodorizing effect. Then, from the measured volatilization amount of 2-methoxyphenol, the improvement rate (%) of the deodorizing effect was calculated according to the following calculation formula. 2-methoxyphenol is a component known to be a major odor source of tobacco odor.

The results obtained are shown in Table 1. As a result, it was confirmed that the medium-chain fatty acid triglyceride has an excellent deodorizing effect on tobacco odor (Examples 1 to 10). In addition, when medium-chain fatty acid triglyceride and long-chain fatty acid triglyceride were used in combination, the deodorizing effect of tobacco odor was further improved (Examples 2 to 7, 9, and 10), and aspartame or menthol was used in combination with these components. In that case, it was confirmed that the deodorizing effect of the tobacco odor was further improved (Examples 9 and 10). In particular, it was confirmed that the deodorizing effect of tobacco odor was dramatically improved when medium-chain fatty acid triglyceride, long-chain fatty acid triglyceride, aspartame, and menthol were contained (Example 10). Although the description in the table is omitted, when aspartame and menthol were used alone, the amount of 2-methoxyphenol volatilized was the same as when they were not used. Therefore, aspartame and menthol alone were used as tobacco. It was confirmed that it did not show the deodorizing effect of odor.

Pharmaceutical Examples Oral compositions (liquid) having the compositions shown in Tables 2 and 3 were prepared by the same method as in the above test examples. When the obtained oral compositions were evaluated for their deodorizing effect on tobacco odor by the same method as in the above test example, it was confirmed that all of them had an excellent deodorizing effect on tobacco odor.

Further, each of the obtained oral compositions was encapsulated by a seamless encapsulation method using the soft capsule coatings A to G having the compositions shown in Table 4, and thus a translucent soft capsule (oral composition per capsule). (Filled with 100 mg of product) was obtained.

Claims (4)

An oral composition for deodorizing tobacco odors, which comprises a medium-chain fatty acid triglyceride , a long- chain fatty acid triglyceride , and aspartame. The oral composition for deodorizing tobacco odor according to claim 1, further containing menthol. The oral composition for deodorizing tobacco odor according to claim 1 or 2 , wherein the content of the medium-chain fatty acid triglyceride is 50 to 99.85% by weight. A soft capsule comprising the oral composition according to any one of claims 1 to 3.