JP7170770B2 - oral composition - Google Patents

Description

Application of Article 30, Paragraph 2 of the Patent Act 1. Sold at: Ministop Shinanomachi Station South Exit Store, etc. (as shown in the attachment) Dates of sale: May 30 to June 26, 2016

The present invention relates to oral compositions. More specifically, the present invention relates to an oral composition for deodorizing tobacco odor, which can effectively deodorize tobacco odor.

BACKGROUND ART In recent years, against the background of increasing demand for oral care, particularly bad breath care, various oral compositions containing deodorizing ingredients for oral care have been developed and marketed. In addition, halitosis includes tobacco odor, garlic odor, alcohol odor, etc., depending on the cause of the odor. The deodorant component is selected and blended according to the cause of the target odor.

In addition, smokers are becoming increasingly conscious of taking care of tobacco odors, and development of an oral composition having a high deodorizing effect against tobacco odors is desired. Conventionally, various studies have been made on oral care products for tobacco odor. For example, in Patent Document 1, food and drink containing, as active ingredients, extracts of one or more plants selected from the group consisting of frankincense, motherwort, red eyed mandarin orange, angelica, and myrtle, reduce tobacco odor. It is disclosed to obtain In addition, Patent Document 2 discloses a tobacco odor deodorizing composition comprising a mandarin orange essential oil or a mandarin orange essential oil fraction from which terpene hydrocarbons have been substantially removed, and a carrier carrying the composition. It is disclosed that tobacco odor can be masked by incorporating the agent into food, drink or oral compositions.

However, the techniques of Patent Literatures 1 and 2 have restrictions on formulation, and there are cases where they cannot cope with recent diversified formulations of oral compositions. Therefore, it is desired to develop a new formulation for an oral composition capable of deodorizing tobacco odors.

JP-A-2006-55055 Japanese Unexamined Patent Application Publication No. 2002-143285

An object of the present invention is to provide an oral composition for deodorizing tobacco odor, which can effectively deodorize tobacco odor.

The present inventors conducted intensive studies to solve the above problems, and found that medium-chain fatty acid triglycerides have a high deodorant effect on tobacco odor, and oral compositions containing medium-chain fatty acid triglycerides are used for deodorizing tobacco odor. found that it can be used for Furthermore, the present inventors have found that an oral composition containing a medium-chain fatty acid triglyceride and a dipeptide sweetener, and an oral composition containing a medium-chain fatty acid triglyceride, a dipeptide sweetener, and menthol have remarkably improved deodorizing effects on tobacco odor. also found The present invention has been completed through further studies based on these findings.

That is, the present invention provides inventions in the following aspects.
Section 1. An oral composition for deodorizing tobacco odor, containing a medium-chain fatty acid triglyceride.
Section 2. Item 2. The oral composition for tobacco odor deodorization according to Item 1, further comprising a long-chain fatty acid triglyceride.
Item 3. Item 3. The oral composition for deodorizing tobacco odor according to Item 2, further comprising a dipeptide sweetener.
Section 4. Item 4. The oral composition for deodorizing tobacco odor according to Item 2 or 3, further comprising menthol.
Item 5. Item 5. The oral composition for deodorizing tobacco odor according to any one of Items 1 to 4, wherein the content of medium-chain fatty acid triglyceride is 50 to 99.85% by weight.
Item 6. A soft capsule filled with the oral composition according to any one of Items 1 to 5.

INDUSTRIAL APPLICABILITY The oral composition of the present invention has an excellent deodorant effect on tobacco odor, and can be used for deodorizing tobacco odor, and is therefore effective as an oral care product for smokers.

The oral composition of the present invention is used for deodorizing tobacco odor, and is characterized by containing a medium-chain fatty acid triglyceride. The oral composition of the present invention is described in detail below.
[Ingredients]
・Medium chain fatty acid triglyceride
The oral composition of the present invention contains medium-chain fatty acid triglycerides to deodorize tobacco odor.

A medium-chain fatty acid triglyceride is a compound having a structure in which three medium-chain fatty acids are ester-bonded to glycerol. In the present invention, the medium-chain fatty acid constituting the medium-chain fatty acid triglyceride may be either saturated fatty acid or unsaturated fatty acid, preferably saturated fatty acid. The medium-chain fatty acid constituting the medium-chain fatty acid triglyceride may have 6 to 12 carbon atoms, and specific examples thereof include caproic acid, caprylic acid, capric acid, and lauric acid. The number of carbon atoms is more preferably 8-12, still more preferably 8-10, from the viewpoint of further improving the deodorizing effect of tobacco odor.

In the medium-chain fatty acid triglyceride used in the present invention, each of the three medium-chain fatty acids contained in one molecule may be the same medium-chain fatty acid, or may be a combination of two or three medium-chain fatty acids. may

Among medium-chain fatty acid triglycerides, medium-chain fatty acid triglycerides containing at least one of caprylic acid, capric acid and lauric acid are preferable from the viewpoint of further improving the deodorizing effect of tobacco odor, and caprylic acid or capric acid Medium-chain fatty acid triglycerides having at least one of acids are more preferred, and medium-chain fatty acid triglycerides having caprylic acid and capric acid are even more preferred.

Medium-chain fatty acid triglycerides having caprylic acid and capric acid are triglycerides also called tri(caprylic/capric)glyceryl, triesters of mixed fatty acids of caprylic and capric acids and glycerin, or Mixed triglycerides of triesters of caprylic acid and glycerin and triesters of capric acid and glycerin. In medium-chain fatty acid triglycerides containing caprylic acid and capric acid, the ratios of caprylic acid and capric acid to the total weight of constituent medium-chain fatty acids are not particularly limited, but caprylic acid is, for example, 30 to 98% by weight. , preferably 80 to 98% by weight, and 1 to 35% by weight, preferably 1 to 20% by weight, of capric acid. The medium-chain fatty acid triglyceride containing caprylic acid and capric acid may also contain lauric acid as a constituent medium-chain fatty acid. In medium-chain fatty acid triglycerides containing caprylic acid and capric acid, when lauric acid is included as a constituent medium-chain fatty acid, the ratio of lauric acid to the total weight of constituent medium-chain fatty acids is not particularly limited, but may be, for example, 0. .1 to 21% by weight, preferably 0.1 to 1% by weight, but the smaller the proportion of lauric acid, the better. Of course, lauric acid may not be included as a constituent medium-chain fatty acid.

The content of the medium-chain fatty acid triglyceride in the oral composition of the present invention may be appropriately set according to the content of other ingredients blended in the oral composition, the form of the oral composition, the amount of intake per dose, and the like. For example, 50% by weight or more can be mentioned. More specifically, the medium-chain fatty acid triglyceride content in the oral composition of the present invention is 50 to 100% by weight, preferably 50 to 99.85% by weight, more preferably 50 to 99% by weight, still more preferably 50 to 95% by weight, particularly preferably 50 to 85% by weight.

• Long-chain fatty acid triglyceride The oral composition of the present invention may contain a long-chain fatty acid triglyceride in order to further improve the deodorizing effect of tobacco odor. Long-chain fatty acid triglyceride alone does not exhibit an effective deodorizing effect against tobacco odor, but the combined use of medium-chain fatty acid triglyceride and long-chain fatty acid triglyceride can dramatically improve the deodorizing effect against tobacco odor. .

A long-chain fatty acid triglyceride is a compound having a structure in which three long-chain fatty acids are ester-bonded to glycerol. In the present invention, the long-chain fatty acid that constitutes the long-chain fatty acid triglyceride may be either saturated fatty acid or unsaturated fatty acid. In addition, the long-chain fatty acid constituting the long-chain fatty acid triglyceride has 14 or more carbon atoms, preferably 14 to 24 carbon atoms, more preferably 16 to 22 carbon atoms, and still more preferably 16 to 18 carbon atoms. More specifically, myristic acid, palmitic acid, palmitoic acid, stearic acid, oleic acid, vaccenic acid, linoleic acid, arachidic acid, arachidonic acid, behenic acid, lignoceric acid and the like can be mentioned.

In the long-chain fatty acid triglyceride used in the present invention, each of the three long-chain fatty acids contained in one molecule may be the same long-chain fatty acid, or a combination of two or three long-chain fatty acids. may

Among long-chain fatty acid triglycerides, long-chain fatty acid triglycerides containing at least one of palmitic acid, oleic acid, and linoleic acid are preferred from the viewpoint of further improving the deodorizing effect of tobacco odors. Long chain fatty acid triglycerides with acid, oleic acid and linoleic acid are more preferred.

Long-chain fatty acid triglycerides having palmitic acid, oleic acid and linoleic acid are (i) triesters of mixed fatty acids of palmitic acid, oleic acid and linoleic acid and glycerin, (ii) palmitic Triesters of glycerin and two mixed fatty acids selected from acid, oleic acid, and linoleic acid, and glycerin and fatty acids not included in the mixed fatty acids among palmitic acid, oleic acid, and linoleic acid. or (iii) mixed triglycerides of palmitic acid and glycerol triesters, oleic acid and glycerol triesters, and linoleic acid and glycerol triesters.

When the oral composition of the present invention contains a long-chain fatty acid triglyceride, the content thereof may be appropriately set according to the form of the oral composition, the amount taken per time, etc. 05 to 50% by weight, preferably 0.1 to 40% by weight, more preferably 0.1 to 30% by weight.

Further, when the oral composition of the present invention contains a long-chain fatty acid triglyceride, the ratio of the long-chain fatty acid triglyceride to the medium-chain fatty acid triglyceride is not particularly limited. Chain fatty acid triglyceride is 0.05 to 100 parts by weight, preferably 0.1 to 100 parts by weight.

Dipeptide sweetener The oral composition of the present invention may contain a dipeptide sweetener together with long-chain fatty acid triglycerides in order to further improve the deodorizing effect of tobacco odor. A dipeptide sweetener alone does not exhibit an effective tobacco odor deodorizing effect, but a combination of a medium-chain fatty acid triglyceride, a long-chain fatty acid triglyceride, and a dipeptide sweetener further improves the tobacco odor deodorizing effect. can be done.

A dipeptide sweetener is a compound in which two amino acids are linked by a peptide bond and exhibits a sweet taste.

The types of dipeptide sweeteners used in the present invention are not particularly limited, but include, for example, aspartame, advantame, and the like. In the present invention, dipeptide sweeteners may be used singly or in combination of two or more.
Among these dipeptide sweeteners, aspartame is preferred from the viewpoint of further improving the deodorizing effect of tobacco odor.

When the oral composition of the present invention contains a dipeptide sweetener, the content thereof may be appropriately set according to the form of the oral composition, the amount per intake, etc. For example, 0.15 to 5% by weight, preferably 0.5 to 5% by weight, more preferably 1 to 3% by weight.

In addition, when the oral composition of the present invention contains a dipeptide sweetener, the ratio of the dipeptide sweetener to the medium-chain fatty acid triglyceride is not particularly limited. is 5 to 60 parts by weight, preferably 11 to 43 parts by weight.

·Menthol The oral composition of the present invention may contain menthol together with long-chain fatty acid triglycerides in order to further improve the deodorizing effect of tobacco odor. Menthol alone does not exhibit an effective tobacco odor deodorizing effect, but the combination of medium-chain fatty acid triglycerides, long-chain fatty acid triglycerides, and menthol can further improve the tobacco odor deodorizing effect. In particular, when medium-chain fatty acid triglycerides, long-chain fatty acid triglycerides, dipeptide sweeteners, and menthol are contained, it is possible to achieve an excellent deodorizing effect against cigarette smell.

The menthol used in the present invention may be any of d-, dl-, and l-forms, preferably d- and dl-forms. Moreover, in the present invention, menthol may be used in the form of an essential oil containing menthol. Menthol-containing essential oils can be appropriately selected from known ones and used, and examples thereof include peppermint oil and peppermint oil. In addition, the description about the content and ratio of the menthol component in this specification is the value converted into the amount of menthol contained in the said essential oil, when using the essential oil containing menthol.

In the case of containing menthol in the oral composition of the present invention, the content thereof may be appropriately set according to the form of the oral composition, the amount per intake, etc. For example, 1 to 30% by weight. , preferably 5 to 20% by weight, more preferably 10 to 20% by weight.

• Other additive components The oral composition of the present invention may contain other nutritional components and pharmacological components in addition to the components described above, if necessary. Such nutritional ingredients and pharmacological ingredients are not particularly limited as long as they can be used in foods, beverages, and pharmaceuticals. Examples include vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin A, and vitamin D. , vitamin E, vitamin K, niacin, pantothenic acid, folic acid, biotin, lycopene and other vitamins; betaine hydrochloride, carnitine chloride, betanechol chloride and other stomachic agents; calcium, sulfur, magnesium, zinc, selenium, iron and other minerals; Proteins such as soybean protein, egg white powder, and whey protein; amino acids such as glycine, alanine, arginine, aspartic acid, cystine, phenylalanine, taurine, and tryptophan; fatty acids such as linoleic acid, γ-linolenic acid, and α-linolenic acid; Caramel pigment, gardenia pigment, anthocyanin pigment, annatto pigment, paprika pigment, safflower pigment, monascus pigment, flavonoid pigment, cochineal pigment, amaranth, erythrosine, allura red AC, new coccine, phloxine, rose bengal, acid red, tartrazine, sun Pigments such as Set Yellow FCF, Fast Green FCF, Brilliant Blue FCF, Indigo carmine; Flavors such as various fruit flavors and essences; Citric acid and its salts, malic acid and its salts, tartaric acid and its salts, acetic acid and its salts, Seasoning agents such as lactic acid and its salts, salt, glutamic acid and its salts, mirin, vinegar, natural fruit juices, plant extracts, cut or powdered fruits and seafood; or its extract; dietary fiber, royal jelly, propolis, honey, chondroitin sulfate, glucosamine, ceramide, hyaluronic acid and other functional ingredients. These additive components may be used singly or in combination of two or more. Moreover, the content of these additive components is appropriately set according to the type of additive components to be used, the form of the oral composition, and the like.

Furthermore, the oral composition of the present invention may contain bases, additives, and the like, as necessary, in order to prepare a desired pharmaceutical form. Such bases and additives are not particularly limited as long as they can be used in foods and pharmaceuticals. Examples include water, oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, and esters. , water-soluble polymers, surfactants, metal soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, UV inhibitors, preservatives, fragrances, powders, thickeners, pigments, A chelating agent and the like are included. These additive components may be used singly or in combination of two or more. In addition, the contents of these bases and additives are appropriately set according to the types of additive components used, the form of the oral composition, and the like.

[Production method]
The oral composition of the present invention can be produced by mixing medium-chain fatty acid triglycerides and other ingredients, if necessary, by a known formulation method according to the form of formulation.

In addition, when the oral composition of the present invention contains a dipeptide sweetener, it is desirable to formulate the dipeptide sweetener in a suspended state because the dipeptide sweetener has low compatibility with long-chain fatty acid triglycerides. .

The method for suspending the dipeptide sweetener is not particularly limited, and examples thereof include a method of performing a stirring treatment such as mechanical stirring or ultrasonic stirring under heating conditions. The conditions during the stirring treatment are not particularly limited, but for example, 40 to 100° C., preferably 45 to 90° C., more preferably 60 to 90° C., still more preferably 70 to 90° C., particularly preferably 80 to 90° C. ° C. for 30 to 300 minutes, preferably 40 to 300 minutes, more preferably 60 to 270 minutes.

[form]
The form of the oral composition of the present invention is not particularly limited as long as it contains the above-described components and is orally ingestible. Among these forms, soft capsules are preferred.

When the oral composition of the present invention is formulated as a soft capsule, the oral composition of the present invention may be encapsulated with a soft capsule shell generally used for soft capsules.

The soft capsule shell may be any material as long as it is capable of forming a coating and contains an edible water-soluble polymer as a base. Specific examples of bases for soft capsule shells include gelatin, agar, xanthan gum, karaya gum, locust bean gum, gum arabic, pullulan, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose and sodium alginate. These bases may be used singly or in combination of two or more. Among these bases, gelatin is preferred.

The content of the base in the soft capsule shell is not particularly limited, but is, for example, 40 to 90% by weight, preferably 50 to 80% by weight, and more preferably 55 to 75% by weight.

In addition to the base, the soft capsule shell may also contain a plasticizer, if necessary, in order to promote plasticization of the base. Examples of plasticizers include glycerin, propylene glycol, sorbitol and the like. These plasticizers may be used singly or in combination of two or more.

When a plasticizer is contained in the soft capsule shell, the content may be appropriately set according to the type of plasticizer used. 20 to 30% by weight is preferred.

Furthermore, if necessary, the soft capsule shell may contain water, emulsifiers, lower alcohols, pH adjusters, buffers, antioxidants, preservatives, Additives such as souring agents, bittering agents, flavors, powders, thickeners, chelating agents, etc. may be included. These additives may be used singly or in combination of two or more.

The method for encapsulating the oral composition of the present invention with a soft capsule shell may be any known method for producing soft capsules, and examples thereof include a rotary soft encapsulation method and a seamless encapsulation method.

[Use and intake]
The oral composition of the present invention is used for deodorizing tobacco odor. The timing of ingestion of the oral composition of the present invention is not particularly limited, and may be before or after smoking, preferably after smoking.

In addition, the intake amount of the oral composition of the present invention is not particularly limited.

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these.

Test Examples Oral compositions having compositions shown in Table 1 (all liquids except Reference Example 2) were prepared. Specifically, for Examples 1 to 8, oral compositions were prepared by mixing predetermined amounts of each component shown in Table 1. In addition, for the oral compositions of Examples 9 and 10, after mixing predetermined amounts of the components other than aspartame, a predetermined amount of aspartame was further added and heated at 85 ° C. for 1 hour with a tornado stirrer ("Tornado PM-202", A suspension was formed by mechanical stirring with AS ONE Co., Ltd. (500 rpm) to obtain an oral composition.

The deodorant effect of the obtained oral composition on tobacco odor was evaluated by the following method. 20 μl of each oral composition was added to 180 μl of 2-methoxyphenol and mixed to obtain a mixed solution. A piece of odorous paper (manufactured by Daiichi Yakuhin Sangyo Co., Ltd.) cut to a length of 5 cm was immersed in this mixture for 30 minutes. Then, using the odorous paper impregnated with the mixed solution, the volatilization amount of 2-methoxyphenol was measured by the headspace GC/MS method. In this measurement system, by adding each oral composition, if the volatilization amount of 2-methoxyphenol is reduced compared to the case where the oral composition is not added, it will have a deodorant effect on tobacco odor. , the smaller the volatilization amount of the 2-methoxyphenol, the higher the deodorizing effect. Then, from the measured volatilization amount of 2-methoxyphenol, the deodorizing effect improvement rate (%) was calculated according to the following formula. 2-Methoxyphenol is a component known to be a major odor source of tobacco odor.

Table 1 shows the results obtained. As a result, it was confirmed that medium-chain fatty acid triglycerides have an excellent deodorizing effect against cigarette smell (Examples 1 to 10). Further, when medium-chain fatty acid triglycerides and long-chain fatty acid triglycerides were used in combination, the deodorizing effect against tobacco odor was further improved (Examples 2 to 7, 9, 10), and aspartame or menthol was used together with these ingredients. In this case, it was confirmed that the effect of deodorizing tobacco odor was further improved (Examples 9 and 10). In particular, it was confirmed that the deodorizing effect against tobacco odor was dramatically improved when medium-chain fatty acid triglycerides, long-chain fatty acid triglycerides, aspartame, and menthol were contained (Example 10). Although not shown in the table, when aspartame and menthol were used alone, the volatilization amount of 2-methoxyphenol was the same as when they were not used. It was confirmed that it does not exhibit an odor eliminating effect.

Formulation Examples Oral compositions (liquid) having compositions shown in Tables 2 and 3 were prepared in the same manner as in the above test examples. The obtained oral composition was evaluated for its deodorant effect on tobacco odor in the same manner as in the above test examples, and it was confirmed that all of the oral compositions had excellent deodorant effect on tobacco odor.

In addition, each of the obtained oral compositions was encapsulated by a seamless encapsulation method using soft capsule shells A to G having the compositions shown in Table 4 to obtain translucent soft capsules (per capsule, oral composition 100 mg of product) was obtained.

Claims (4)

An oral composition for deodorizing tobacco smell, containing 50-99.85% by weight of medium-chain fatty acid triglyceride and 0.05-50% by weight of long-chain fatty acid triglyceride. The oral composition for deodorizing tobacco odor according to claim 1, further comprising a dipeptide sweetener. The oral composition for deodorizing tobacco odor according to claim 1 or 2, further comprising menthol. A soft capsule filled with the oral composition according to any one of claims 1 to 3 .