JPH01180817A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity having excellent removing effects on fowl breath, containing a water-soluble fraction of Zingiberis Rhizoma. CONSTITUTION:Dried Zingiberis Rhizoma is treated with >=the same weight of water, preferably 5-10 times as much as water at room temperature or under boiling for 3-10hr. After the extraction treatment, the treated substance is separated by an ordinary method such as filtration or centrifuging preferably under heating into an extracted solution and extraction residue. The extracted solution is collected and a water-soluble fraction is obtained. 0.003-10wt.%, preferably 0.005-5wt.% calculated as solid content of the fraction is used to give a composition for oral cavity.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to an oral composition that has an excellent halitosis-removing effect by incorporating a water-soluble fraction of Soyoukyou.

(Prior art and its problems) Chlorophyll, β-nchodextrin, lecithin, etc. are generally known as components having a bad breath removal effect. Although these ingredients have been recognized to have excellent breath odor removal effects, no product has been found that satisfies all requirements.

For example, chlorophyll has a high halitosis removal effect against various odors and is a promising ingredient, but as it becomes more readily available, rolophyll, or chlorophyllins, has a high coloring property and colors the inside of the oral cavity dark green. . Although coloring can be avoided if used at low concentrations, the halitosis removal effect is insufficient.

Additionally, β-noclodegistrin, lecithin, and the like are also used as components for removing bad breath, but they have almost no effect on normal breath odor (generally referred to as mercaptan odor).

(Means for Solving the Problems) The present inventors have demonstrated a high removal effect on normal bad breath,
Furthermore, in order to obtain a breath odor removing component that can be easily produced, we have developed Z ingiberisRhi.
It has been found that an aqueous extract (water-soluble fraction) of Zoma) can satisfy the above requirements. That is, the present invention provides an oral composition containing a water-soluble fraction of Soyflower.

Z ingiberis Rhizo
ma) is a crude drug listed in the Japanese Pharmacopoeia, and the essential oil is 025-3.
%, and is generally used as a compounding ingredient in aromatic stomachic medicines, as well as as a cold medicine, antiemetic, and analgesic. It is also known that when incorporated into oral compositions, the organic solvent extract of Ginger can inhibit plaque formation and acid production, thereby increasing the effect of preventing dental caries and periodontal disease. (Japanese Unexamined Patent Publication No. 56-83416). However, neither ginger per se nor organic solvent extracts of ginger have been used for breath odor removal. On the contrary, it has been reported that the organic solvent (methanol) extract of ginger has almost no deodorizing ability for methyl mercaptan odor (Japanese Society of Agricultural Chemistry Vol. 1.5g, No.
, 6 pp585-589.1984).

The water-soluble fraction used in the present invention is obtained by extracting ginger with water, and has a deodorizing effect by directly acting on normal bad breath.

The raw materials used to obtain the water-soluble fraction of Gingerbread include dried herbal medicines, dried shreds, dry powders, etc. of Ginkgo, the residues obtained by extracting oil from these by steam distillation, the residues of other essential oils, or Oleoresin and its extraction residue obtained by extracting Gingerbread with polar solvents such as ethyl ether, ethylene chloride, dioxane, acetone, lower alcohols such as ethanol and methanol, ethyl acetate, propylene glycol, and glycerin; -Oleoresins obtained by extraction with non-polar solvents such as hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, benzene, etc., and their extraction residues. is used. In order to obtain a water-soluble fraction of Soyoukyou from these raw materials, one or more of these raw materials are extracted with water, and the extract (extract liquid or a product from which water has been distilled off) is collected. It is preferable.

In the present invention, this extract can be used as it is or in the form of a concentrate. However, this extract can be used as a steam distillation residue obtained by steam distillation, or this extract or the steam distillation residue can be used on activated carbon, diatomaceous earth, etc. , those treated with an adsorbent such as acid clay, and the residue obtained by steam distillation after treating the extract with an adsorbent can also be suitably used as the water-soluble fraction of ginger. Alternatively, the extract may be used after removing water by methods such as vacuum concentration, freeze drying, and spray drying. Note that any known method can be used for the extraction method, but preferably, for example, water of equal or higher weight, preferably 5 to 10 times the weight, is added to dried ginger, and the mixture is heated at room temperature or under boiling for 0.5 to 0.05 hours. The extraction process is performed for 24 hours, preferably 3 to 10 hours, and after the extraction process, the extract is separated into an extract and an extraction residue and collected by a conventional method such as filtration, centrifugation, decantation, etc., preferably under heating. The method will be adopted. In this case, if necessary, the extraction residue may be subjected to the same extraction process again to obtain an extract, which can be used in combination with the previous extract.

In the present invention, oral compositions refer to dentifrices such as troches, tablets, pills, candies, drinks, chewing gum, jelly, mouthwashes, oral pasta, toothpastes, moist toothpastes, and powdered toothpastes. etc.

The amount of the water-soluble fraction of the ginger to be incorporated into the oral composition is preferably 0.001 to 20%, particularly 0.003 to 10% of the total solid content. More preferably, it is blended in an amount of 0005 to 5%.

The oral composition of the present invention may contain appropriate components depending on the type. For example, in the case of troches, excipients such as glucose, lactose, and sucrose, binders such as gum arabic, crystalline cellulose, and sodium carboxymethyl cellulose, disintegrants such as starch, crystalline cellulose, and calcium carboxymethyl cellulose, and stearic acid. It is produced according to a conventional method by mixing ingredients such as a lubricant such as magnesium and soyosugar fatty acid ester, a sweetener such as zacharin sodium and glycyrrhizin, and a flavoring agent. Further, in tablets, pills, candies, drinks, etc., ingredients are appropriately blended according to the properties of the product.

Furthermore, the oral composition of the present invention includes natural chlorophyll,
Copper chlorophyllin Na, iron chlorophyllin Na.

β-cyclodextrin, lecithin, lysozyme chloride,
Active ingredients such as ρ-menthol can also be blended.

(Effects of the Invention) The oral composition according to the present invention has a fast-acting and excellent halitosis-removing effect on normal halitosis due to the combination of the water-soluble fraction of Aspergillus chinensis. In particular, the water-soluble fraction of Ginkgo shows the above-mentioned effects even at a relatively low concentration. In addition, the water-soluble fraction of Gingerbread has had its essential oil components removed, so it does not have the unique spiciness of Gingerbread. In addition, it has little odor and is light brown in color, so the odor of the oral composition,
It does not lose its color and is not colored like chlorophyll. Furthermore, Ginkgo is a crude drug listed in the Japanese Pharmacopoeia, and the use of its water-soluble fraction in oral compositions is extremely safe.

(Example) The present invention will be explained in more detail with reference to Examples.

The present invention should not be construed as being limited to these examples.

Example 1 Powder 10 obtained by pulverizing dried herbal medicine of Ginkgo using a mill
Add 800ml of water to 09 and heat on a water bath at 50-60'C.
The mixture was heated for a certain period of time, and then the aqueous extract was filtered while still warm, fresh water was added to the residue, and the same operation was repeated twice, for a total of three extraction operations. The aqueous extracts were combined and freeze-dried to obtain pale brown powders s, sy (Ginkgo aqueous extract I).

The following experiment was conducted using the obtained ginger water extract. 22-23 Place 100xy of the extract in a liquor test tube and add 311Q of purified water. Seal tightly with a silicone cap, and after stirring, add 3°Ong of methyl mercaptan.
Shake for a minute. A gas of 101ρ was collected from the headspace and immediately subjected to gas chromatography (detector FPD).
). The results were expressed as the residual rate of methyl mercaptan, which is an indicator of general bad breath, using the following calculation formula. Results first
It is shown in the table-7. As a control, the same amount of lactose was added instead of the ginger extract, and the same operation was performed.

Residual rate (%) - Methyl mercaptan concentration (ng/i
, 0) C: Control methyl mercaptan concentration (ng/l,
OmQ) Example 2 1Q of water was added to dried minced ginger 1009, and the mixture was decooked until the amount of water was reduced to about half, and then the preliquid was filtered off. The preliquid was freeze-dried to obtain light brown powder 4o7 (Ginkgo aqueous extract II).

The obtained extract was tested in the same manner as in Example 1. The results are shown in Table 1.

Example 3 500 mQ of water was added to Dried Ginger Powder 1009, stirred at room temperature for 8 hours, and then the water extract was filtered. The aqueous extract was concentrated under reduced pressure to obtain light brown paste 2.2@ (Ginkgo aqueous extract III).

The obtained extract was tested in the same manner as in Example 1. The results are shown in Table 1.

Table 1 From Table 1, it was confirmed that the ginger water extract effectively deodorized the odor of methyl mercaptan, which is a causative component of bad breath.

Example 4 This example shows a comparison of the halitosis-removing effects of the water-soluble fraction of ginger of the present invention and other compounds having halitosis-removing ability.

The same test as in Example 1 was carried out using the water extract of N. japonica obtained in the same manner as in Example 3 in the sample amounts shown in Table 2. The residual rate of methyl mercaptan is shown in Table 2.

For comparison, similar experiments were conducted using conventionally used β-cyclodextrin, lecithin, and sodium copper chlorophyllin. The results are shown in Table 2.

From the upper table of Table 2, the halitosis removing effect of sodium copper chlorophyllin and aqueous extract of Nordicum japonica is significantly higher than that of β-cyclodextrin and renotin.

Example 5 This example shows a comparison of the coloring properties of the aqueous extract of N. chinensis of the present invention and other compounds having the ability to remove bad breath.

Tablets containing the ginger water extract obtained in the same manner as in Example 3 were manufactured. That is, powdered sugar was added to the ginger water extract to prepare granules, glucose, gum arabic, and magnesium stearate were added thereto, and the mixture was compression molded to obtain tablets (700ff9).

The tablets were licked in the mouth for 5 minutes, and the coloring of the tongue was visually observed. The results are shown in Table 3.

For comparison, similar tests were conducted on sodium copper chlorophyllin, β-cyclodextrin, and renotin. The results are shown in Table 3.

From the above table, copper chlorophyllin sodium has a coloring property in the mouth, which is not preferable, but the ginger water extract does not have a coloring property in the mouth.

Formulation examples are shown below. In addition, all percentages indicate weight percent.

[Formulation Example 1] Lozenge Gum Arabic 6.O glucose 720 Seratin 30 Flavor
02 Dextranase
Ol Kryrhequinodine Gluconate 001 Chrysanthemum Water Extract III
1.0 spearmint oil
02 Sodium ascorbate
01 Wednesday
Total remaining 1000 [Formulation example 2] Troche (%) Glucose 835β
-cyclodextrin io,.

Sodium copper chlorophyllin 02 Soybean phospholipid 01 Perilla extract I11 5.0 Gum arabic 10 Fragrance
0.1 Magnesium stearate 0.1 Total 1000 [Formulation example 3] Pills (%) White sugar 75.9 Gum arabic powder 30 Crystalline cellulose 70 Cornstarch
100 Porphyra aqueous extract 1
1.0β-cyclodextrin
30 fragrances
01 Total 1000 [Formulation Example 4] Candy (%) Granulated sugar 585 Starch syrup
374 Nyokiyo Water Extract ■ 3.0 Flavor
10 fragrances
O1 total 100.0 [Formulation example 5] Drink (%) Fructose glucose liquid sugar 50 Honey 50 Canola aqueous extract 1 1.0 dl-malic acid
02 fragrance
01 Synthetic preservative
0.01 [Formulation Example 6] Oral pasta (%) Polyoxyethylene monostearate 20 Sorbitan monooleate 20 Cetyl alcohol 20 Palmityl alcohol 30 Propylene glycol
150 carboxymethylcellulose
50 gelatin 1
．． 0 Saccharin 0.2 Chlorophyllus aqueous extract II 1.0 Fragrance 10 Lysozyme chloride 5000 units/9 Chlorhexidine hydrochloride 0.01 Water
Remaining - total 10
00 [Formulation Example 7] Chewing gum (%) Gum base 40.0 Calcium carbonate 20 Water syrup
15.0 powdered sugar
40.0 peppermint oil
02 dextranase
01 Water extract I [1,0 Water
Total remaining 1000 [Formulation example 8] Gargling tablet (%) Sodium hydrogen carbonate 54 Sodium phosphate dibasic 10 Polyethylene glycol 30 Flavoring
10 oleic acid
o, i Sodium monofluorophosphate
0.1 Chlorhexin hydrochloride
0.05 Cucumber aqueous extract■
05 Allantoin Ol citric acid 170 water
Total remaining 100.0 [Formulation Example 9] Mouthwash (%) Ethanol 200 Saccharin Sodium 005 Fragrance
15 Sodium monofluorophosphate 01 Chlorhegicinone gluconate 001 Laurylnoethanolamide O3 Water extract n
O,05 glycyrrhizinate
0.1 allantoin
01 Wednesday
Remaining total i o o,.

[Formulation Example 10] Toothpaste (%)

Claims (1)

[Scope of Claims] 1. An oral composition containing a water-soluble fraction of ginger. 2. The oral composition according to item 1, wherein the water-soluble fraction is present in a solid content of 0.003 to 10% by weight. 3. The oral composition according to item 1, wherein the oral composition is a tablet, pill, drink, or candy.