JP2006022053A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity, which is highly safe and effectively prevents or ameliorates a foul breath. <P>SOLUTION: The composition for the oral cavity comprises an extract extracted from a roasted material prepared by roasting bran obtained from seeds of at least one kind of plant. The bran is rice bran. The amount of the extract extracted from the roasted material mixed is 0.1-20 wt.%. The composition comprises a propolis extract besides the extract extracted from the roasted material. The amount of the propolis extract mixed is 0.1-20 wt.%. The composition comprises a crude medicine having hemostatic and/or antiphlogistic and anti-inflammatory effect, its extract or processed material. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an oral composition.

  In recent years, people's desire for cleanliness has increased, and in particular, interest in bad breath has been increasing.

  In general, halitosis is a malodor produced from the oral cavity together with exhaled breath, and is mainly caused by volatile sulfur compounds such as methyl mercaptan.

  By the way, as means for preventing and improving bad breath, many oral compositions such as dentifrice and mouthwash containing a deodorant component have been proposed.

  By the way, such a composition for oral cavity is known to contain a plant-derived component as a deodorizing component from the viewpoint of safety (for example, see Patent Document 1).

  However, the conventional oral composition has a problem that a sufficient deodorizing effect cannot be obtained and the sustainability of the effect is low.

JP 2001-151654 A

  An object of the present invention is to provide an oral composition that is highly safe and can effectively prevent and improve bad breath.

Such an object is achieved by the present inventions (1) to (8) below.
(1) An oral composition comprising an extract obtained by roasting a koji obtained from at least one seed and then extracting the koji.

  (2) The oral cavity composition according to (1), wherein the rice bran is a rice bran.

  (3) The composition for oral cavity as described in said (1) or (2) with which the propolis extract is mix | blended.

  (4) The composition for oral cavity according to any one of (1) to (3), wherein a copper chlorophyllin salt is blended.

  (5) The composition for oral cavity according to any one of (1) to (4), wherein isopropylmethylphenol is blended.

  (6) The composition for oral cavity according to any one of the above (1) to (5), wherein a herbal medicine having hemostatic and / or anti-inflammatory / anti-inflammatory effects, an extract thereof, and a processed product are blended.

  (7) The composition for oral cavity according to (6) above, wherein the herbal medicine is a plant belonging to the genus Carrot family.

  (8) The oral cavity composition according to the above (7), wherein the plant is Tabata.

  According to the present invention, since the extract obtained by roasting rice cake after roasting is used as a deodorizing component, safety is high, and bad breath can be effectively prevented and improved.

  In particular, when used in combination with propolis extract, it is possible to exert a higher bad breath prevention effect and a higher bactericidal effect due to its synergistic effect.

Hereinafter, preferred embodiments of the oral composition of the present invention will be described in detail.
The oral composition in the present specification includes toothpastes, toothpastes, liquid dentifrices, dentifrices such as liquid dentifrices, troches, tablets, creams, ointments, patches, mouthwashes Agent, chewing gum and the like.

  The composition for oral cavity according to the present invention is used for the purpose of prevention and improvement of bad breath, and contains an extract extracted from a roasted product obtained by roasting straw obtained from at least one seed. It has the characteristics.

  Here, the cocoon refers to a mixture of the seed coat and germ obtained when the seeds of a plant are fertilized.

  An extract extracted from a roasted product obtained by roasting koji (hereinafter referred to as roasted koji extract) contains maltol and derivatives thereof (hereinafter referred to as maltols) as main components.

  It is considered that the deodorizing effect of the roasted koji extract is mainly due to the chemical reaction between the maltols and malodorous components. As described above, since the deodorizing effect is exhibited by the chemical reaction, the deodorizing effect is exhibited for a long time in the composition for oral cavity of the present invention containing the roasted koji extract.

  Moreover, the roasted rice cake extract used by this invention contains various polyphenols as a component which contributes to a deodorizing effect other than the maltol mentioned above.

  Therefore, the roasted koji extract used in the present invention exhibits a high deodorizing effect due to the synergistic effect of the deodorizing function of maltols and the deodorizing function of various polyphenols, and further exhibits the effect for a long time. It will be a thing.

  In addition, the roasted koji extract used in the present invention has an effect of improving storage stability, particularly an excellent effect of preventing discoloration.

  Such an effect is particularly prominent when used in combination with a propolis extract described later. This is because the roasted koji extract suppresses quality deterioration of the propolis extract and suppresses discoloration.

  Examples of the koji include rice koji, barley koji, wheat koji, soybean koji, etc., and one or more of these can be used in combination.

  Among the above, it is particularly preferable to use rice bran. Thereby, a deodorizing effect becomes more remarkable.

  The roasted rice cake extract used for the composition for oral cavity of this invention can be obtained as follows, for example. In the following description, a case where rice bran is typically used as the rice bran will be described.

First, prepare rice bran.
Next, the rice bran is roasted under predetermined conditions (for example, a temperature of 120 to 210 ° C., a time of 20 to 60 minutes).

  Next, the roasted rice bran is subjected to a first extraction treatment using an extraction solvent under predetermined conditions (for example, a temperature of 80 to 100 ° C., a time of 60 to 180 minutes). Thereby, the component which contributes to the deodorization in rice bran is extracted in an extraction solvent, and a 1st extract is obtained.

  Examples of the extraction solvent in the first extraction treatment include water, ethanol, 1,3-butylene glycol, and the like, and one or more of these can be used in combination. Among these, water is preferably used as the extraction solvent.

Next, after filtering the obtained 1st extract, a filtrate is concentrated.
Next, the concentrate obtained by concentration is spray-dried.

  Next, an extraction treatment is performed on the dried product obtained by spray drying using an extraction solvent under predetermined conditions (for example, a temperature of 40 to 70 ° C., a time of 60 to 180 minutes).

  As this extraction solvent, for example, an alcohol aqueous solution such as ethanol, propanol, or 1,3-butylene glycol can be used. In this case, the alcohol concentration is preferably 60% or more.

  Thereafter, the second extract is filtered and the filtrate is concentrated. Thereby, the roasted rice bran extract (roasted rice bran extract) used for the composition for oral cavity of this invention is obtained.

  The blending amount of such roasted koji extract is preferably 0.1 to 20 wt%, more preferably 0.5 to 10 wt%, and even more preferably 1 to 5 wt%. Thereby, the bad breath can be prevented and improved more effectively. On the other hand, if the blending amount of the roasted potato extract is less than the lower limit, a sufficient deodorizing effect may not be obtained depending on the dosage form of the oral composition. On the other hand, even if the blending amount of the roasted koji extract is increased above the upper limit, not only a sufficient increase in the effect cannot be expected, but also the feeling of use may be impaired.

  Moreover, it is preferable that the composition for oral cavity of this invention is mix | blended with the propolis extract other than the component mentioned above.

Propolis extract is a naturally derived component having effects such as deodorization, sterilization, and anti-inflammation.
The propolis extract used in the present invention is an extract of a spider-like substance (generally referred to as “propolis”) collected from a plant by bees and produced with a hydrophilic organic solvent.

  More specifically, this spider-like substance is obtained from the nest of the honey bee family (Apismellifera L., Apis indica RODOSZKOWSKI), and its main component is a flavonoid. As a specific extraction solvent, ethanol is well known and is typically used in the present invention.

  Moreover, it does not specifically limit as a form of a propolis extract, For example, there exist liquid, solid form, a powder form, etc. Such a propolis extract is generally available on the market, and a commercially available product can be used in the present invention.

  The blending amount of this propolis extract is preferably 0.01 to 10.0 wt%, and more preferably 1.0 to 5.0 wt%. Thereby, the more superior deodorizing effect is exhibited. On the other hand, if the blending amount of the propolis extract is less than the lower limit value, a sufficient bactericidal effect and anti-inflammatory effect can be obtained depending on the types of other components contained in the oral composition and the blending amount thereof. There may not be. On the other hand, if the blending amount of the propolis extract exceeds the upper limit, a sufficient effect corresponding to the blending amount cannot be obtained, and the usability may be impaired.

  As described above, the propolis extract has an excellent effect and is effective as one component of the oral composition. However, when the deodorant component and the propolis extract that have been used conventionally are used in combination, On the contrary, the deodorizing effect of each may be inhibited, and the effects of propolis extract (effects such as bactericidal and anti-inflammatory) may be inhibited.

  However, when the roasted rice cake extract and the propolis extract are used in combination, the high deodorizing function of the roasted rice cake extract, on the contrary, without inhibiting the effects such as sterilization and anti-inflammation of the propolis extract, It was found that a particularly excellent deodorizing effect was exhibited by the synergistic effect with the deodorizing function of the propolis extract. Furthermore, it has also been found that the combined use of the roasted koji extract and the propolis extract suppresses the unique odor of the propolis extract and improves the feeling of use of the oral composition. In addition, in the deodorant component used conventionally, when trying to acquire such an effect, the compounding quantity must be enlarged and the problem that a feeling of use may be impaired on the contrary may arise.

  In addition to the above-mentioned components, the composition for oral cavity of the present invention contains a herbal medicine having hemostasis and / or anti-inflammatory / anti-inflammatory effects, an extract thereof, and a processed product (hereinafter also simply referred to as a herbal medicine-derived product). It is preferable.

  Examples of herbal medicines that have a hemostatic effect include urgon, geese, button pi, and plants belonging to the genus Carrot genus. In addition, examples of herbal medicines having anti-inflammatory / anti-inflammatory effects include bacmonds, ogi, licorice, aloe, teas (and their catechins), plants belonging to the genus Carrot genus, and the like. Among the above-mentioned, it is particularly preferable to use a plant belonging to the genus Carrot family.

  Such plants belonging to the genus Carrot family contain triterpene saponins.

  Triterpene-based saponins are a kind of surfactant, and are mainly components having analgesic, anti-inflammatory, anti-inflammatory and other effects.

  Examples of the plant belonging to the genus Carrot genus include ginseng, bamboo ginseng, tabuchi, eleganius, and the like, and one or more of them can be used in combination.

  Among the above-mentioned, it is preferable to use Tabashi. Tabashi contains particularly more triterpene saponins than other plants belonging to the genus Carrot, and exhibits higher analgesic, anti-inflammatory and anti-inflammatory effects.

  Further, Tabanachi contains ODAP (β-N-Oxalyl-α, β-diampropionic acid) called dencithin, and the herbal medicine derived from Tabuchi has an excellent hemostatic effect.

  Examples of the site used for obtaining the crude drug-derived product include the plant itself, leaves, stems, rhizomes, roots, and the like, and one or more of these can be used in combination. Especially, since many triterpene-type saponins mentioned above are contained, a root is used suitably.

  When these are taken into consideration, it is preferable to use the root of Tabana as the plant part to be used. Thereby, effects such as higher analgesia, anti-inflammation, anti-inflammation, and hemostasis are exhibited.

  The composition for oral cavity of the present invention may contain the above-described herbal medicine or its part as it is as a herbal medicine-derived material, and, for example, those obtained by drying / pulverizing, extracting (extract), processing You may mix | blend what was processed (processed material). Moreover, you may mix | blend what refine | purified them with the column etc.

  The extract (extract extract) should be obtained by performing extraction by a generally known method using a polar or non-polar solvent, removing the insoluble material by operations such as filtration and centrifugation, etc., if necessary, and concentrating. Can do.

  The processed product can be obtained by fermentation by generally known microorganisms, reaction by enzyme, and the like.

  Examples of microorganisms used in fermentation include Aspergillus genus, Trichoderma genus, Lactobacillus genus, Bacillus genus and the like.

  Examples of the enzyme used for the enzyme reaction include lactase enzymes, cellulase enzymes, hemicellulase enzymes, pectinase enzymes, and the like.

  If the composition for oral cavity of the present invention contains a herbal medicine-derived product as described above, periodontitis that is a factor of bad breath due to the high anti-inflammatory and anti-inflammatory effects of the herbal medicine-derived product. Gingivitis and the like can be suppressed, and as a result, a higher deodorizing effect is exhibited.

  The blending amount of such crude drug-derived products is preferably 0.01 to 15.0 wt%, and more preferably 0.05 to 10.0 wt%. Thereby, while suppressing the bleeding of the affected part by periodontitis, gingivitis etc. more effectively, the inflammation of an affected part can be suppressed.

  In addition, as a form (shape) of a crude drug origin thing, any, such as a powder form, a granular form, a small lump shape, a pellet form, a liquid form, may be sufficient, for example.

  In the oral composition of the present invention, various components may be blended depending on the dosage form. For example, when the composition for oral cavity of the present invention is applied to a toothpaste, an abrasive, a wetting agent, a binder, a foaming agent, a sweetener, an antiseptic, a fragrance component, a medicinal component, and the like can be blended.

  As abrasives, silica-based abrasives such as silica gel, precipitated silica, pyrogenic silica, hydrous silicic acid, silicic anhydride, zeolite, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate, dicalcium phosphate Non-hydrated toothpaste calcium hydrogen phosphate, calcium pyrophosphate, tribasic magnesium phosphate, tribasic calcium phosphate, aluminum hydroxide, alumina, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, zirconium silicate, synthetic resin system An abrasive | polishing agent etc. are mentioned, Among these, 1 type (s) or 2 or more types can be used together.

  Although the compounding quantity of an abrasive | polishing agent is not specifically limited, 3-60 wt% is preferable and it is more preferable that it is 10-45 wt%.

  Examples of the wetting agent include polyhydric alcohols such as glycerin, concentrated glycerin, diglycerin, sorbitol, maltitol, dipropylene glycol, propylene glycol, 1,3-butylene glycol, and xylitol. More than one species can be used in combination.

  Although the compounding quantity of a wetting agent is not specifically limited, 1-60 wt% is preferable and it is more preferable that it is 5-50 wt%.

  Examples of the binder include carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol ester alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate and derivatives thereof, xanthan gum, guar gum, Examples thereof include gelatin, agar, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, and the like, and one or more of these can be used in combination.

  Although the compounding quantity of a binder is not specifically limited, 0.1-5.0 wt% is preferable and it is more preferable that it is 0.5-3.0 wt%.

  Examples of the foaming agent include sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkylsulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acyl glutamate and the like, 2-alkyl- N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxy Ethylene fatty acid ester etc. are mentioned, Among these, 1 type (s) or 2 or more types can be used together.

  Although the compounding quantity of a foaming agent is not specifically limited, 0.1-10.0 wt% is preferable and it is more preferable that it is 0.5-5.0 wt%.

  Examples of the sweetening agent include saccharin sodium, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, and the like, and one or more of these may be used in combination. it can.

  Although the compounding quantity of a sweetening agent is not specifically limited, 0.005-5.0 wt% is preferable and it is more preferable that it is 0.01-3.0 wt%.

  Examples of preservatives include parabens such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben, sodium benzoate, phenoxyethanol, alkyldiaminoethyl glycine hydrochloride, and the like, and one or more of these are used in combination. be able to.

  The blending amount of the preservative varies depending on the type and the like, but is preferably 0.005 to 5.0 wt%, and more preferably 0.01 to 3.0 wt%.

  Examples of the fragrance component include l-menthol, anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamic aldehyde, trans-2-hexenal, etc. Two or more kinds can be used in combination. Although these components may be mix | blended with a single item, you may mix | blend the essential oil etc. which contain these. In addition to the above fragrance components, fragrance components such as aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes, ketones, and lactones, and essential oils may be blended within a range that does not interfere with the effects of the present invention.

  Although the compounding quantity of a fragrance | flavor component is not specifically limited, It is preferable that it is 0.02-2 wt%, and it is more preferable that it is 0.05-1.5 wt%.

  Medicinal ingredients include lysozyme chloride, monofluorophosphate, sodium fluoride, potassium fluoride, sodium monofluorophosphate, polyethylene glycol, polyvinylpyrrolidone, zeolite, hinokitiol, ascorbic acid, chlorhexidine salts, cetylpyridinium chloride, benzalkonium chloride , Benzethonium chloride, bisabolol, triclosan, isopropylmethylphenol, tocopherol acetate, ε-aminocaproic acid, tranexamic acid, aluminum hydroxyl allantoin, aluminum lactate, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinate, copper chlorophyllin salt, guaiazulene sulfonate Dextranase, pyridoxine hydrochloride, etc., and one or more of these It is possible to focus.

  Among the above, when a copper chlorophyllin salt is used as a medicinal component, the deodorizing effect of the roasted potato extract as described above can be further enhanced. In particular, when the three components of roasted koji extract, propolis extract, and copper chlorophyllin salt are used in combination, the above-described synergistic effect of the roasted koji extract and propolis extract can be made more remarkable.

  Moreover, in the above-mentioned, when isopropylmethylphenol is used as a medicinal component, a higher bactericidal effect is manifested by a synergistic effect with the bactericidal action of the propolis extract.

  The compounding amount of the active ingredient in the oral composition varies depending on the type and the like, but is preferably 0.001 to 5.0 wt%, and more preferably 0.01 to 3.0 wt%.

  In addition to the above-mentioned components, for example, pigments such as Blue No. 1, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, chelating agents such as edetate, cha extract, tea dry distillation liquid, sodium glutamate And so on.

  In addition, the composition for oral cavity of this invention which combined the said component can be manufactured according to a conventional method, The manufacturing method is not specifically limited. The obtained composition such as a toothpaste can be used by being filled into an aluminum tube, a laminate tube, a glass vapor deposition tube, a plastic tube, a plastic bottle, an aerosol container or the like.

  As mentioned above, although the composition for oral cavity of this invention was demonstrated, this invention is not limited to this. For example, the composition for oral cavity of this invention can mix | blend the component which has arbitrary functions other than the component mentioned above.

  Moreover, the manufacturing method of the roasted rice cake extract used for the composition for oral cavity of this invention is not limited to the method as mentioned above, You may obtain by a different method.

  In addition, as the roasted koji extract used in the oral composition of the present invention, for example, a product extracted with a solvent such as water in the above-described production method or a product obtained by concentrating them may be used as it is. The spray-dried product may be used as it is, or the spray-dried product extracted with a solvent such as ethanol may be used as it is.

  The oral composition of the present invention can be applied not only to human toothpastes, but also to animal toothpastes.

Next, specific examples of the present invention will be described.
Example 1
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 3.0
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Examples 2 to 5)
A toothpaste was produced in the same manner as in Example 1 except that the blending amount of the roasted rice bran extract and the blending amounts of other components were as shown in Table 1.

(Example 6)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 2.0
Propolis extract: 3.0
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Examples 7 to 10)
A toothpaste was produced in the same manner as in Example 6 except that the blending amount of the roasted rice bran extract, the blending amount of the propolis extract and the blending amount of other components were as shown in Table 1.

(Example 11)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 5.0
Propolis extract: 3.0
Copper chlorophyllin salt: 0.05
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Example 12)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 10.0
Propolis extract: 5.0
Isopropylmethylphenol: 0.02
Tocopherol acetate: 0.1
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Example 13)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 3.0
Propolis extract: 3.0
Copper chlorophyllin salt: 0.04
Isopropylmethylphenol: 0.02
Tocopherol acetate: 0.1
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Example 14)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 15.0
Tabuchi powder (dried and crushed): 5.0
Calcium pyrophosphate: 20.0
Silicic anhydride: 5.0
Concentrated glycerin: 15.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Example 15)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 15.0
Propolis extract: 5.0
Tabuchi powder (dried and crushed): 3.0
Calcium pyrophosphate: 20.0
Silicic anhydride: 5.0
Concentrated glycerin: 15.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Example 16)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 10.0
Propolis extract: 5.0
Tabuchi extract (extracted extract): 3.0
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 20.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Example 17)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Roasted rice bran extract: 5.0
Propolis extract: 5.0
Tabuchi extract (extracted extract): 10.0
Calcium pyrophosphate: 20.0
Silicic anhydride: 5.0
Concentrated glycerin: 20.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Comparative Example 1)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: appropriate amount

(Comparative Example 2)
A toothpaste was produced by a conventional method according to the following formulation (unit: wt%).

Propolis extract: 3.0
Calcium pyrophosphate: 25.0
Silicic anhydride: 5.0
Concentrated glycerin: 30.0
Sodium carboxymethylcellulose: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Ethyl paraoxybenzoate: 0.1
Fragrance: 1.0
Water: Appropriate amount Table 1 shows the ingredients of each Example and each Comparative Example.

<Evaluation>
[Evaluation of deodorizing effect]
The deodorizing effect on methyl mercaptan was evaluated by the following method.

  First, 10 g of the toothpaste obtained in each of the above Examples and Comparative Examples was taken in a 50 mL beaker and dispersed using 25 g of water to prepare a dispersion.

  Next, 5 g (in the case of control, only water) of the dispersion is collected in a 20 mL test tube.

  0.5 mL of a 1 μg / mL solution of methyl mercaptan (manufactured by Wako Pure Chemical Industries, Ltd.) was added to a test tube containing the dispersion of each example and each comparative example and water as a control, and immediately plugged with a silicon stopper. The mixture was stirred for 5 seconds with a touch mixer and kept in a 37 ° C. water bath.

After 6 minutes, 5 mL of air was injected with a gas tight syringe, and after stirring for 5 seconds, 5 mL of the headspace gas was withdrawn, and methyl mercaptan was extracted by gas chromatography (column temperature: 100 ° C., carrier gas: N ₂ , detector: FPD). The peak area was measured. The same sample was repeated twice, and the deodorization rate (%) was calculated from the average value as follows.

Deodorization rate (%) = {(C−S) / C} × 100
C: Control methyl mercaptan peak area
S: Methyl mercaptan peak area after dispersion addition

The evaluation was performed according to the following five steps based on the deodorization rate.
A: Deodorization rate is 90% or more.
A: Deodorization rate is 75% or more and less than 90%.
○: Deodorization rate is 50% or more and less than 75%.
Δ: Deodorization rate is 20% or more and less than 50%.
X: Deodorization rate is 20% or less.

[Sustainability evaluation of deodorizing effect]
Three healthy adult males with normal dentition and no serious illness in the oral cavity were subjects, and the dentifrices obtained in each of the examples and comparative examples were used, and each dentifrice was used. Then, the bad breath after 2 hours was evaluated in the following two stages.

○: Almost bad breath was not felt.
X: Bad breath was felt.
The above evaluation results are shown in Table 2.

As is clear from Table 2, the dentifrices obtained in each Example had an excellent deodorizing effect. In particular, the examples in which the roasted rice bran extract and the propolis extract are used in combination show a particularly excellent deodorizing effect, and the examples in which the roasted rice bran extract, the propolis extract and the copper chlorophyllin salt are used in combination are further The tendency was remarkable.
On the other hand, the dentifrice obtained in each comparative example was low in deodorizing effect.

  Moreover, it was confirmed that the dentifrice obtained in each Example can suppress bad breath for a long time compared with a comparative example, and has high persistence.

Claims (8)

  An oral composition comprising an extract obtained by roasting koji obtained from at least one seed and then extracting.   The composition for oral cavity according to claim 1, wherein the rice bran is rice bran.   The composition for oral cavity of Claim 1 or 2 with which the propolis extract is mix | blended.   The oral composition according to any one of claims 1 to 3, wherein a copper chlorophyllin salt is blended.   The composition for oral cavity according to any one of claims 1 to 4, wherein isopropylmethylphenol is blended.   The oral composition according to any one of claims 1 to 5, wherein a herbal medicine having hemostatic and / or anti-inflammatory / anti-inflammatory effects, an extract thereof, and a processed product are blended.   The composition for oral cavity according to claim 6, wherein the herbal medicine is a plant belonging to the genus Carrot family.   The composition for oral cavity according to claim 7, wherein the plant is Tabata.