JP6405396B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition containing thymoquinone in which discoloration is suppressed, and a method for preventing discoloration of a thymoquinone-containing composition.

Conventionally, toothpastes, mouthwashes, and the like have been used to keep teeth clean and keep the oral cavity healthy. More recently, toothpastes and mouthwashes are not limited to such health and hygiene, but are expected to have more functions.
In recent years, interest in the prevention of bad breath has increased due to an increase in hygiene awareness of the oral environment. The main cause of bad breath is a volatile sulfur compound (VSC) such as methyl mercaptan or hydrogen sulfide, which is generated by the degradation of oral dirt (food residue, exfoliated mucous membrane, etc.) by the bacteria that cause bad breath. In particular, methyl mercaptan is a substance that feels offensive odor even at low concentrations, so even a small amount gives discomfort to many people.

  For this reason, various techniques for suppressing bad breath have been studied so far. For example, there has been proposed a method for capturing and deodorizing halitosis-causing substances by blending plant extracts such as sage, rosemary, Lamiaceae, and seaweed that are highly safe to the human body (Patent Document 1). ~ 3). Further, thymoquinone or black cumin seed extract is known as a deodorant having a good deodorizing effect on malodorous components such as mercaptans (Patent Document 4).

JP-A-57-203445 JP-A-57-204278 Japanese Patent Laid-Open No. 62-152463 JP 2011-168554 A

However, although the plant extracts described in Patent Documents 1 to 3 have high safety to the human body, the deodorizing power is weak and the deodorizing effect is insufficient. In addition, when a large amount of the plant extract is blended, there is a problem of feeling of use such as taste and discoloration after long-term storage.
On the other hand, the extract of thymoquinone or black cumin seed described in Patent Document 4 is a component expected in oral use as a deodorant having a good deodorizing effect on malodor components such as mercaptans. In solution, there was a problem that discoloration of the solution occurred after long-term storage.
Therefore, it is required to suppress discoloration after long-term storage in an oral composition containing thymoquinone having a good deodorizing effect.

  Then, the objective of this invention is providing the composition for oral cavity containing the thymoquinone by which discoloration was suppressed. Moreover, it is providing the method of preventing discoloration of a thymoquinone containing composition.

  As a result of intensive studies, the present inventors have determined that one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants are used in oral cavity containing thymoquinone. It has been found that the above-mentioned problems can be solved by making it contained in a composition for use, or by making it present in a composition containing thymoquinone, and the present invention has been completed.

That is, the present invention is achieved by the following (1) to (4).
(1) An oral composition containing one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants, and thymoquinone.
(2) An oral composition containing one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants, and processed black cumin seeds.
(3) The composition for oral cavity according to (1) or (2) above, containing 2.5 to 5000 parts by weight of the surfactant per 1 part by weight of thymoquinone.
(4) A method for preventing discoloration of a thymoquinone-containing composition, wherein thymoquinone and at least one surfactant selected from nonionic surfactants, anionic surfactants and cationic surfactants are present.

  The composition for oral cavity containing thymoquinone of the present invention can maintain high safety to the human body by containing thymoquinone, and can exhibit a good deodorizing effect against malodorous components such as mercaptans. However, by further containing one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants, discoloration of the composition is suppressed and excellent. It has the effect of having storage stability.

Hereinafter, the present invention will be described in more detail.
The oral composition of the present invention contains one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants along with thymoquinone. In the present invention, the nonionic surfactant, the anionic surfactant, and the cationic surfactant suppress the discoloration of the oral composition containing thymoquinone, and have an effect of excellent stability during storage. This is based on finding a point that can be demonstrated.

Specifically, as one aspect of the composition for oral cavity of the present invention, with one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants, An oral composition containing thymoquinone.
Another aspect of the composition for oral cavity of the present invention is a black cumin together with one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants. An oral composition containing a processed seed product. As will be described later, the processed black cumin seed contains thymoquinone.

<Thymoquinone>
Thymoquinone used in the present invention is represented by the following formula and has a chemical name of 2-isopropyl-5-methyl-1,4-benzoquinone. Thymoquinone is known as an essential oil component contained in black cumin seeds and the like. Thymoquinone exhibits a good deodorizing effect against malodorous components such as mercaptans.

As the thymoquinone used in the present invention, both natural products and synthetic products can be used. When using a natural product, plants containing thymoquinone such as oregano, thyme, and winter savory can be used in addition to the black cumin seed described later. Plants containing these thymoquinones can also be used that have been variously processed by the methods described later, as with black cumin.
Moreover, as a synthetic product of thymoquinone, the Tokyo Chemical Industry Co., Ltd. product name Thymoquinone etc. can be used, for example.

<Processed black cumin seeds>
Black cumin has the scientific name Nigella sativa L. Is a plant. The essential oil component of black cumin seeds contains thymoquinone. For example, a black cumin seed steam-distilled extract obtained by steam distillation of black cumin seeds described later contains about 40 w / w% of thymoquinone. In addition to thymoquinone, for example, α-pinene, p-cymene, γ-terpinene, carvacrol and the like are included.

  The black cumin seed processed product in the present invention is exemplified by black cumin seed extract, crushed product, dried product and the like, and contains thymoquinone. The processed black cumin seeds are appropriately used for various processing such as extraction processing, pulverization processing, purification processing, concentration processing, and drying processing (including freeze-drying processing) depending on the form and the intended dosage form. It refers to what was prepared as a processed product.

  When the processed product is an extract, its production method (extraction conditions and the like) is not particularly limited, and a conventionally known method may be followed. For example, an extract can be obtained by extracting, solvent extraction, water distillation, steam distillation, or the like after any part of black cumin seed as it is or after cutting, pulverizing, or the like. As a method for solvent extraction, a method known in the art may be employed, and conventionally known methods such as water (including warm water and hot water) extraction, alcohol extraction, supercritical extraction, microwave extraction, and press extraction are known. The extraction method can be used.

When solvent extraction is performed, examples of the solvent include water; alcohols such as methanol, ethanol, isopropyl alcohol, ethylene glycol, propylene glycol, and 1,3-butylene glycol (anhydrous, regardless of water content); acetone, and the like Ketones; esters such as diethyl ether, dioxane, acetonitrile, and ethyl acetate; hexane, xylene, benzene, chloroform, and the like.
Preferred solvents for solvent extraction are water, alcohols, ketones, hexane, and the like, and more preferred are water, alcohols, and ketones. These solvents may be used alone or in combination of two or more.

  The obtained extract may be used as it is, or may be used after being dried. Moreover, you may refine | purify and a concentration process etc. to the obtained extract as needed. Examples of the purification treatment include filtration, adsorption, decolorization, and separation using an ion exchange resin or activated carbon column. Moreover, as a concentration process, conventional methods, such as an evaporator, can be illustrated. These may be further subjected to a drying treatment such as freeze-drying, and may be further pulverized according to a conventionally known method. Moreover, you may use the extract obtained by dissolving in water, ethanol, etc. as needed.

<Non-ionic surfactant>
Examples of the nonionic surfactant used in the present invention include polyoxyethylene (hereinafter also referred to as POE) hydrogenated castor oil, POE alkyl ethers such as POE cetyl ether and POE stearyl ether, polyoxyethylene polyoxy POE / POP alkyl ether such as propylene (hereinafter also referred to as POE / POP) cetyl ether, POE sorbitan fatty acid ester such as POE sorbitan coconut fatty acid ester (also referred to as POE coconut oil fatty acid sorbitan), glycerin fatty acid such as polyglyceryl monolaurate Esters, polyethylene glycol fatty acid esters such as polyethylene glycol monostearate, POE / POP block polymers, POE alkylphenyl ethers, POE / POP fatty acid esters, sorbita Fatty acid esters, propylene glycol fatty acid esters, and POE phytosterol and the like, may be used either singly or in combination.
In addition, from the viewpoint that the discoloration of the oral composition containing thymoquinone can be further suppressed, and from the viewpoint of less influence on taste, POE hydrogenated castor oil, POE alkyl ethers such as POE cetyl ether and POE stearyl ether, POE · POP POE / POP alkyl ethers such as cetyl ether, POE sorbitan fatty acid esters such as POE sorbitan coconut oil fatty acid ester (also referred to as POE coconut oil fatty acid sorbitan), and polyethylene glycol fatty acid esters such as polyethylene glycol monostearate are preferred.
Among these, POE hydrogenated castor oil, POE alkyl ethers such as POE cetyl ether and POE stearyl ether are particularly preferable because they have less influence on taste.
Here, the influence on taste refers to the influence on bitterness, irritation, oily odor (odor), and the like, as described in the test examples described later.

<Anionic surfactant>
Examples of the anionic surfactant used in the present invention include POE alkyl ether phosphates such as POE lauryl ether phosphate and sodium POE lauryl ether phosphate or POE alkyl ether phosphates, lauroyl sarcosine sodium, and myristoyl sarcosine. N-acyl amino acid salts such as sodium, alkyl ether carboxylates such as sodium POE lauryl ether acetate, N-acyl taurine salts such as sodium lauroylmethyl taurate, alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sulfosuccinic acid Examples thereof include sulfonates such as sodium di (2-ethylhexyl), POE alkyl ether sulfates, and alkyl phosphates, and one kind or two or more kinds can be used.
Among these, from the viewpoint that the discoloration of the oral composition containing thymoquinone can be further suppressed, POE alkyl ether phosphate such as POE lauryl ether phosphate and sodium POE lauryl ether phosphate, POE alkyl ether phosphate, lauroyl N-acyl taurine salts such as sodium methyl taurate, alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, and sulfonates such as sodium di (2-ethylhexyl) sulfosuccinate are preferred.
Among these, N-acyl taurine salts such as sodium lauroylmethyl taurate, and alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate are particularly preferable because they have little influence on taste.

<Cationic surfactant>
Examples of the cationic surfactant used in the present invention include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, and POE alkylamine / fatty acid amide. Single or 2 or more types can be used. Among these, cetylpyridinium chloride and benzethonium chloride are preferable from the viewpoint that the discoloration of the oral composition containing thymoquinone can be further suppressed and the influence on the taste is small.

  The nonionic surfactant, the anionic surfactant and the cationic surfactant may be contained alone or in combination of two or more in the oral composition of the present invention. Moreover, it is preferable to contain the said surfactant so that it may become 0.01-30 w / w%, for example with respect to the oral cavity composition whole quantity of this invention, and it will be 0.01-20 w / w%. It is more preferable to contain it, and it is further more preferable to contain so that it may become 0.1-1 w / w%. If it is 0.01 w / w% or more, discoloration of the composition for oral cavity containing a thymoquinone can fully be suppressed. Moreover, by making content of surfactant into 30 w / w% or less, when the composition for oral cavity of this invention is a liquid, it can suppress solidifying and can maintain the state of a liquid. it can.

  The nonionic surfactant, the anionic surfactant and the cationic surfactant are preferably contained in an amount of 2.5 to 7500 parts by weight with respect to 1 part by weight of thymoquinone. The content is more preferably 5 to 5000 parts by weight, still more preferably 12.5 to 5000 parts by weight, and particularly preferably 25 to 250 parts by weight. If it is the said range, discoloration of the composition for oral cavity containing a thymoquinone can fully be suppressed.

  Further, among nonionic surfactants, anionic surfactants and cationic surfactants, from the viewpoint of having little influence on taste to the oral composition of the present invention, nonionic surfactants are used. An agent is preferably used.

  The form of the composition for oral cavity of the present invention is not particularly limited, and examples thereof include forms such as liquids, solids, gels, and semi-solids such as pastes. Specifically, mouthwash, liquid toothpaste, cool in mouth It can be in the form of toothpastes such as an agent, mouthwash (gargle), liquid toothpaste, and toothpaste, mouthwash (gargle), troche, chewing gum and the like.

  Among these, from the viewpoint that the effects of the present invention are better achieved, that is, from the viewpoint that discoloration of the composition for oral cavity containing thymoquinone can be suppressed more favorably, mouthwash, liquid toothpaste, mouth freshener, It is preferably used as a liquid oral composition such as a mouthwash (gargle). These can be made into preparations by known means.

  When setting it as the said composition for liquid oral cavity, water, ethanol, a wetting agent, etc. should just be contained according to each form. It is preferable to use a solvent mainly composed of water from the viewpoint of application in the oral cavity, and it is preferable to include other solvents such as ethanol and a wetting agent in an amount smaller than water. For example, 0-20 w / w% is mentioned as the quantity of ethanol contained in a composition. Moreover, as a quantity of the water contained in a composition, 50-99 w / w% is mentioned, for example. As a quantity of the wetting agent contained in a composition, 0-30 w / w% is mentioned, for example.

<Color difference (ΔE)>
As described above, the oral composition containing thymoquinone of the present invention contains at least one surfactant selected from nonionic surfactants, anionic surfactants, and cationic surfactants. By containing, discoloration is suppressed. Discoloration of the oral composition of the present invention is confirmed by measuring the color difference ΔE on the appearance or using a colorimetric color difference meter immediately after the preparation of the composition and after a predetermined number of days. it can. For example, ZE-2000 (manufactured by Nippon Denshoku Industries Co., Ltd.) can be used as the colorimetric color difference meter.
The color difference ΔE can be calculated by an equation of ΔE = [(ΔL) ² + (Δa) ² + (Δb) ² ] ^1/2 by measuring L, a, and b values using a colorimetric color difference meter.
ΔL = L value immediately after preparation−L value after storage Δa = a value immediately after preparation−a value after storage Δb = b value immediately after preparation−b value after storage

  Preferably, the color difference ΔE of the composition immediately after preparation of the composition and after storage for 7 days at 25 ° C. is less than 3.00, more preferably less than 2.00, and even more preferably less than 1.00. It is the composition for oral cavity prepared. Alternatively, the color difference ΔE of the composition immediately after preparation of the oral composition and after storage at 5 ° C. or 50 ° C. for 10 days is preferably less than 3.00, more preferably less than 2.00, and even more preferably 1. It is a composition for oral cavity prepared so that it may become less than 00.

  The discoloration (color difference ΔE) of the composition for oral cavity of the present invention is the kind and content of the above-mentioned nonionic surfactant, anionic surfactant and cationic surfactant, and the content of thymoquinone. It can adjust by changing suitably.

<Other ingredients>
The composition for oral cavity of the present invention can contain various components applicable to the oral cavity as long as the effects of the invention are not impaired.
For example, purified water and water such as ionic water; ethanol; humectants such as glycerin and propylene glycol; sweeteners such as steviaside, xylitol, erythritol, sorbitol, and sodium saccharin; chlorhexidine salt, triclosan, and isopropylmethylphenol Bactericides; enzymes such as proteases; fluoride ion sources such as sodium fluoride, fluorophosphate and fluoroborate; phosphate ion sources such as calcium phosphate and hydroxyapatite; parahydroxybenzoate esters and sodium benzoate Preservatives such as peppermint oil, peppermint oil, menthol, carvacrol, eucalyptus oil, eugenol, anethole, cineol, hinokitiol and other essential oil components; Scan, and crude drugs such Toukiekisu; Blue No. 1, Yellow No. 4, Red No. 102, and pigments such as green No. 201, and various perfumes.

  In addition, lysozyme chloride, dextranase, mutanase, glycyrrhizinate and derivatives thereof, glycyrrhetinate and derivatives thereof, azulene, azulene sulfonic acid, dihydrocholesterol, epidihydrocholesterin, allantoin, allantoinchlorohydroxyaluminum, chloride Examples include sodium, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, epsilon aminocaproic acid, tranexamic acid, polyphosphate, thymol, copper chlorophyllin sodium, vitamins, and amino acids.

  In the method for preventing discoloration of the thymoquinone-containing composition of the present invention, in addition to thymoquinone, one or more surfactants selected from nonionic surfactants, anionic surfactants and cationic surfactants are present. To prevent discoloration of the thymoquinone-containing composition. As the nonionic surfactant, the anionic surfactant and the cationic surfactant, those described above can be used. The said surfactant suppresses discoloration of the composition containing thymoquinone, and can exhibit the effect excellent in the stability at the time of a preservation | save.

  The method for preventing discoloration of the present invention can be used for a thymoquinone-containing composition, and the form of the composition is not particularly limited, and examples thereof include forms such as semisolids such as liquids, solids, gels, and pastes. Is done. Specifically, it can be used in oral preparations such as mouthwash, liquid toothpaste, mouth freshener, mouthwash (gargle), and liquid toothpaste, deodorant, fragrance, and bactericidal agent, Various known components can be included as long as the effects of the invention are not impaired.

  The nonionic surfactant, the anionic surfactant and the cationic surfactant may be present alone or in combination of two or more in the thymoquinone-containing composition. Moreover, it is preferable to make the said surfactant exist so that it may become 0.01-30 w / w% with respect to the thymoquinone containing composition whole quantity, for example, it exists so that it may become 0.01-20 w / w% More preferably, it is made to exist so that it may become 0.1-1 w / w%. If it is the said range, discoloration of a thymoquinone containing composition can fully be suppressed.

  The nonionic surfactant, the anionic surfactant and the cationic surfactant are preferably present in the liquid composition so as to be 2.5 to 7500 parts by weight with respect to 1 part by weight of thymoquinone. More preferably 2.5 to 5000 parts by weight, still more preferably 12.5 to 5000 parts by weight, and even more preferably 25 to 250 parts by weight. Particularly preferred. If it is the said range, discoloration of a thymoquinone containing composition can fully be suppressed.

  Although the preferable formulation example is shown below, this invention is not limited to these.

  EXAMPLES Hereinafter, although an Example and a comparative example further demonstrate this invention, this invention is not restrict | limited to the following example.

(Test Example 1)
In accordance with the formulation of Table 6 and Table 7 below, various components were mixed to prepare various compositions of Examples 1 to 13 and Comparative Examples 1 and 2. Immediately after the preparation of the various compositions obtained and after color storage at 25 ° C. for 7 days in a thermostatic bath, the visual appearance and ΔE by a colorimetric color difference meter were measured and calculated. The results are shown in Table 7. In Table 7, the case where there was no visual discoloration compared with immediately after the preparation was evaluated as “◯”, and the case where visual discoloration occurred was evaluated as “x”.
Measurement of the color difference by calorimetric color difference meter, the calculation of the Delta] E is, L, a, b values were measured using colorimetric color sakei ZE-2000 (manufactured by Nippon Denshoku Industries Co., ^{Ltd.), ΔE = [(ΔL)} 2 + (Δa) ² + (Δb) ² ] ^1/2 was calculated according to the formula ^1/2 .
ΔL = L value immediately after preparation−L value after storage Δa = a value immediately after preparation−a value after storage Δb = b value immediately after preparation−b value after storage

  From the results of Table 7, while Examples 1 to 13 containing a nonionic surfactant or an anionic surfactant are markedly suppressed in discoloration of the composition, an amphoteric surfactant was added. Comparative Examples 1 and 2 caused significant discoloration of the composition. Thereby, it was confirmed that the nonionic surfactant and the anionic surfactant sufficiently suppress the discoloration of the thymoquinone-containing composition.

(Test Example 2)
In accordance with the formulation of Table 6 and Table 8, various components were mixed to prepare various compositions. Immediately after the preparation of the various compositions obtained and in a thermostatic bath, the color change after storage at 5 ° C. and 50 ° C. for 10 days was measured and calculated by visual appearance and ΔE by a color difference meter. The results are shown in Table 8. The visual evaluation criteria, color difference measurement, and ΔE calculation were performed according to the method of Test Example 1.

From the results shown in Table 8, the above examples containing a nonionic surfactant, an anionic surfactant or a cationic surfactant were subjected to high temperature conditions (50 ° C.) and low temperature conditions (5 ° C.). Also, the discoloration of the composition was remarkably suppressed.
On the other hand, in Comparative Examples 1 and 2 containing an amphoteric surfactant, a significant discoloration of the composition occurred.
As a result, nonionic surfactants, anionic surfactants, and cationic surfactants can sufficiently suppress discoloration of the thymoquinone-containing composition even under high-temperature and low-temperature conditions. confirmed.

(Test Example 3)
In this test, in the thymoquinone-containing composition, the relationship between the surfactant content and the discoloration of the composition was confirmed. Thymoquinone (standard product) manufactured by Tokyo Chemical Industry Co., Ltd., product name Thymoquinone was used.

Various components were mixed according to the formulation of Table 9 and Table 10 below to prepare various compositions having different surfactant contents.
The pH change and color change of various compositions obtained by the above preparation were measured immediately after preparation and after storage at 50 ° C. for 10 days in a thermostatic bath. For color change, ΔE was measured and calculated using a color difference meter. The results are shown in Table 10. The color difference measurement and ΔE calculation were performed in the same manner as in Test Example 1.

  As can be seen from the results of Test Example 3, it was confirmed that discoloration was suppressed in any of the compositions having different surfactant contents. That is, it was confirmed that the discoloration of the composition could be suppressed if the surfactant content was at least 0.01 w / w% (2.5 parts by weight per 1 part by weight of thymoquinone). Moreover, it was confirmed that discoloration of a composition is suppressed, so that there is much content of surfactant.

(Test Example 4)
In this test, the effect on the state taken by the thymoquinone-containing composition when the surfactant content was increased was confirmed.
First, various components were mixed according to the formulation of Table 11 and Table 12 below to prepare various compositions.
The prepared various compositions were filled in an 80 mL capacity PET container and then sealed with a PE cap.
Thereafter, the container was laid down with the liquid temperature at 5 ° C., the surface of the composition after 5 seconds was visually confirmed, and the states of various compositions were evaluated according to the following criteria.
○: The composition surface after laying down for 5 seconds became horizontal (maintaining a liquid state)
X: The composition surface after laying down for 5 seconds did not become horizontal (solidified)
The results are shown in Table 12.

  From the above results, in order to maintain the liquid state in the thymoquinone-containing composition of the present invention, the upper limit of the content is 20 w / w% to 30 w / w% (depending on the type of surfactant). It turned out that it is preferable to set it as 5000-7500 weight part per 1 weight part of thymoquinone.

(Test Example 5)
In this test, various compositions containing a surfactant and thymoquinone were prepared, and the influence on the taste by the type of the contained surfactant was evaluated.
First, according to the formulation of Table 13 and Table 14 below, various components were mixed to prepare various compositions containing a surfactant and thymoquinone. Subsequently, the taste of each of the various compositions obtained was evaluated by eight panelists. Taste evaluation was performed by assigning points according to the evaluation criteria shown below for a total of four evaluation items of bitterness, irritation, oily odor (odor), and taste synthesis. For each item, “◎” when the average score of 8 panelists is 3.5 or more and 4.0 or less, “○” when the average score is 3.0 or more and less than 3.5, and “average” Was evaluated as “Δ” when the score was 2.0 or more and less than 3.0, and “X” when the average score was less than 2.0. The results of evaluation are shown in Table 14.

[Bitter taste]
4 points: no bitterness 3 points: bitterness is faint 2 points: bitterness is slightly 1 point: bitterness is considerable

[stimulation]
4 points: No stimulation 3 points: Slight stimulation 2 points: Slight stimulation 1 point: Stimulation is considerable

[Odor smell (odor)]
4 points: No oily odor 3 points: Oily odor is faint 2 points: Oily odor is slightly 1 point: Oily odor is considerable

[Taste synthesis]
4 points: no influence on taste 3 points: slight influence on taste 2 points: slight influence on taste 1 point: considerable influence on taste

  As can be seen from the results shown in Table 14, non-ionic surfactants among surfactants have relatively little bitterness, irritation, and oily odor (odor), resulting in less influence on taste. It was.

Claims (3)

Timoquinone, POE hydrogenated castor oil, POE cetyl ether, POE stearyl ether, POE · POP cetyl ether, polyethylene glycol monostearate, polyglyceryl monolaurate, sodium POE lauryl ether, sodium POE lauryl ether acetate per 1 part by weight of thymoquinone Oral composition containing 2.5 to 5000 parts by weight of one or more selected from sodium lauroylmethyltaurine, sodium di (2-ethylhexyl) sulfosuccinate, and cetylpyridinium chloride . Processed black cumin seed and 1 part by weight of thymoquinone in the processed black cumin seed, POE hydrogenated castor oil, POE cetyl ether, POE stearyl ether, POE / POP cetyl ether, polyethylene glycol monostearate, polyglyceryl monolaurate, POE Oral composition containing 2.5 to 5000 parts by weight of one or more selected from sodium lauryl ether phosphate, sodium POE lauryl ether acetate, sodium lauroylmethyl taurate, sodium di (2-ethylhexyl) sulfosuccinate, and cetylpyridinium chloride object. In a thymoquinone-containing composition, POE hydrogenated castor oil, POE cetyl ether, POE stearyl ether, POE / POP cetyl ether, polyethylene glycol monostearate, polyglyceryl monolaurate, sodium POE lauryl ether, POE lauryl per 1 part by weight of thymoquinone A method for preventing discoloration of a thymoquinone- containing composition , comprising 2.5 to 5000 parts by weight of at least one selected from sodium ether acetate, sodium lauroylmethyltaurine, sodium di (2-ethylhexyl) sulfosuccinate, and cetylpyridinium chloride .