KR20170117406A - Liquid oral composition - Google Patents

Abstract

(C) a nonionic surfactant and (D) an amphoteric surfactant in an ethanol-free liquid oral composition containing (A) potassium nitrate and (B) cetylpyridinium chloride, By mass or more and less than 92% by mass and the pH of the composition is set to 6.8 or more and less than 8.0, and precipitation of insoluble precipitates formed by the combination of (A) and (B) cetylpyridinium chloride is suppressed, A liquid oral composition having excellent caries inhibiting effect is provided.

Description

Liquid oral composition

The present invention relates to a liquid oral composition containing no potassium nitrate, which is excellent in an inhibitory effect on perceived hypersensitivity and a sterilizing effect of floating bacteria in the oral cavity.

As a preventive measure for dentin hypersensitivity, potassium nitrate known as an effective ingredient is incorporated into an oral composition (Patent Documents 1 and 2). This potassium nitrate has a problem that insoluble precipitates are formed in the presence of sodium lauryl sulfate generally contained in oral compositions. Patent Document 3 discloses that potassium hydroxide and sodium lauryl sulfate are added to oral compositions containing polyhydric alcohol, amphoteric surfactant , Precipitation of potassium lauryl sulfate is prevented and low-temperature precipitation is suppressed.

In addition, in particular, in the liquid oral composition, a non-alcohol type liquid preparation having less mucosal irritation and hypotonicity is more suitable for suppressing the sensory hyperactivity.

On the other hand, cetylpyridinium chloride, which is a cationic fungicide, has an excellent germicidal effect against airborne bacteria in the oral cavity and is effective for preventing or inhibiting oral diseases such as caries, but is easily affected by surfactants. Patent Document 4 discloses that a specific compound is added to an oral composition containing a cationic fungicide of the acetophenone type and a nonionic surfactant to prevent inactivation of the cationic fungicide by the nonionic surfactant, One technique has been proposed.

Patent Document 1: U.S. Patent No. 3,863,006 Patent Document 2: JP-A-7-101842 Patent Document 3: JP-A-2005-68071 Patent Document 4: Japanese Patent Application Laid-Open No. 60-255717 Patent Document 5: JP-A-2013-35792 Patent Document 6: Japanese Patent Application Laid-Open No. 2007-84471

Therefore, it is more effective in preventing or suppressing oral diseases, if it is possible to inhibit the hypersensitivity in a non-alcohol type liquid oral preparation containing potassium nitrate and at the same time to exhibit a high sterilizing power against the floating bacteria in the oral cavity. And it has been desired to develop liquid oral preparations having such excellent properties.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a liquid oral composition containing no potassium nitrate, which is excellent in inhibiting the hypersensitivity and sterilizing the floating bacteria in the oral cavity.

The inventors of the present invention have found that (A) a nonionic surfactant (C) and a nonionic surfactant (B) are added to a liquid oral composition having no ethanol blended with potassium nitrate (B) and cetylpyridinium chloride (A) and (B) by combining the component (D) and the amphoteric surfactant (E) with the water content of 55 mass% or more and less than 92 mass% It is possible to obtain a non-alcoholic liquid oral composition which suppresses the precipitation of insoluble precipitates that are produced and has an effect of inhibiting the hypersensitivity and sterilization of floating bacteria in the oral cavity, and can be used to suppress the hypersensitivity and caries, The present invention has been accomplished.

In other words, it was expected that by adding cetylpyridinium chloride, which is a cationic fungicide, to a liquid oral composition containing potassium nitrate, it is possible to impart a sensory hypersensitivity effect and a germicidal effect in the oral cavity, but potassium nitrate and cetylpyridinium chloride Is mixed with an ethanol-containing liquid oral composition does not cause any particular problem, when potassium nitrate and cetylpyridinium chloride are used in combination with a liquid oral composition having no ethanol-containing low-polarity, insoluble precipitates It was found that the effect of inhibiting the hypersensitivity is lowered and the sterilizing effect is not sufficiently manifested. For this reason, a new problem has arisen in that potassium nitrate and cetylpyridinium chloride are used in combination in an ethanol-free liquid oral composition without precipitation of an insoluble precipitate to exert satisfactorily the action effects of potassium nitrate and cetylpyridinium chloride. In order to solve these problems, the inventors of the present invention have conducted further investigations. As a result, they have found that (C) a nonionic surfactant and (D) an amphoteric surfactant are added in combination, The precipitation of insoluble precipitates caused by the combined use of the above components (A) and (B) is suppressed even in the course of time, and a high antinociception inhibitory effect and a sterilizing effect of a floating bacteria can be simultaneously given, It was possible to maintain the appearance stably and to suppress the bitter taste (bitterness) to give a good feeling of use. In this case, although cetylpyridinium chloride is susceptible to being influenced by a surfactant such as a nonionic surfactant and inactivated, in the present invention, the combination of the surfactants (C) and (D) (Water content) and pH of the water-absorbing agent specifically function within a specific range to give distinct and remarkable action effects.

Therefore, the liquid oral composition containing no ethanol in the present invention has substantially no precipitation of insoluble precipitates even after 4 weeks from the preparation of a composition for oral cavity as evidenced by the later-described examples, the appearance is stable with time, A hypersensitive hypersensitive effect and a germicidal effect in the oral cavity are high, and a bitter taste after use is suppressed, so that a good taste is obtained with good taste.

Patent Document 3 is directed to inhibiting the precipitation of potassium lauryl sulfate caused by the combined use of potassium nitrate and sodium lauryl sulfate in the oral composition and Patent Document 4 discloses that the cationic fungicide There is no mention of the prevention of inactivation and the use of a cationic bactericide in combination with potassium nitrate. Patent Documents 5 and 6 disclose liquid oral compositions containing potassium nitrate and cetylpyridinium chloride, but these are ethanol blended compositions. Patent Literatures 3 to 6 show that inhibition of precipitation of insoluble precipitates caused by the combined use of potassium nitrate and cetylpyridinium chloride in a liquid oral composition without ethanol is unpredictable.

Accordingly, the present invention provides the liquid oral composition described below and a method for inhibiting the precipitation of insoluble precipitates in the composition.

[One]

(C) a nonionic surfactant and (D) an amphoteric surfactant in an ethanol-free liquid oral composition containing (A) potassium nitrate and (B) cetylpyridinium chloride, By mass to less than 92% by mass, and the pH of the composition is set to 6.8 or more and less than 8.0.

[2]

(C) the liquid non-ionic surfactant is a polyoxyethylene hardened castor oil, and (D) the amphoteric surfactant is an alkylamide betaine or a salt thereof.

[3]

1] or [2], wherein the nonionic surfactant (C) is a polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, (D) the amphoteric surfactant is coconut fatty acid amide propyl betaine, ≪ / RTI >

[4]

The liquid oral composition according to [1], [2] or [3], wherein 0.1 to 2 mass% of component (C) and 0.1 to 2 mass% of component (D) are combined.

[5]

The liquid oral composition according to any one of [1] to [4], wherein the content of the component (A) is 0.01 to 10 mass% and the content of the component (B) is 0.001 to 0.1 mass%.

[6]

A liquid oral composition according to any one of [1] to [5], which is a mouth rinse.

[7]

The liquid oral composition according to any one of [1] to [6], which is suitable for inhibiting the hypersensitivity and dental caries.

[8]

(C) a nonionic surfactant and (D) an amphoteric surfactant in an ethanol-free liquid oral composition containing (A) potassium nitrate and (B) cetylpyridinium chloride, (A) nitric acid potassium and (B) cetylpyridinium chloride in the liquid oral composition, wherein the composition has a pH of not less than 92 mass% and a pH of the composition of not less than 6.8 and less than 8.0. A method for inhibiting precipitation of insoluble precipitates.

[9]

A method for inhibiting the precipitation of an insoluble precipitate caused by the combined use of (A) potassium nitrate and (B) cetylpyridinium chloride in a liquid oral composition according to [8], wherein the composition for liquid oral use is a detergent.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a composition for oral administration of potassium nitrate-free ethanol-free formulation having an excellent inhibitory effect on hypersensitivity and a germicidal effect in the oral cavity.

Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention is characterized by containing (A) potassium nitrate, (B) cetylpyridinium chloride, (C) a nonionic surfactant, (D) an amphoteric surfactant, (E) water (water) (No blending).

(A) Potassium nitrate is compounded as an active ingredient for preventing or treating dental hypersensitivity, and is a hypersensitivity inhibitor.

The blending amount of potassium nitrate as the component (A) is preferably 0.01 to 10% (mass%, the same applies hereinafter), more preferably 0.1 to 7% of the whole composition. The more the compounding amount is, the higher the inhibitory effect of inhibiting the hypersensitivity, but the less than 10% is more suitable for inhibiting sufficient precipitation and suppressing the bitter taste.

(B) Cetylpyridinium chloride is a cationic fungicide and a disinfectant for oral bacteria. Cetylpyridinium chloride may be commercially available.

The blending amount of cetylpyridinium chloride as the component (B) is preferably 0.001 to 0.1%, more preferably 0.005 to 0.1%, and still more preferably 0.01 to 0.05% of the whole composition. The greater the blending ratio, the higher the bactericidal effect. However, the blending amount of 0.1% or less is more suitable for inhibiting sufficient precipitation and suppressing the bitter taste.

In the present invention, the combination of (C) a nonionic surfactant and (D) an amphoteric surfactant is important for manifesting the effect. If the component (C) or the component (D) is not used, an insoluble precipitate is precipitated, and the effect of suppressing the hypersensitivity and the effect of sterilizing the floating bacteria are poor. Also, the bitter taste is not suppressed and the feeling of use is poor.

Examples of the nonionic surfactant (C) include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and polyglycerin fatty acid ester. One or more of these surfactants may be used. In particular, ethylene oxide (EO Polyoxyethylene hydrogenated castor oil having an average addition mole number of 40 to 100 mol, in particular 60 to 100 mol, of alkyl groups having 16 to 18 carbon atoms and an average addition molar number of EO of 10 to 40 mol, especially 20 to 40 mol, of poly Oxyethylene alkyl ethers, and decaglycerol mono fatty acid ester polyglycerin fatty acid esters having 12 to 18 carbon atoms, particularly 12 to 14 carbon atoms. Among them, polyoxyethylene hydrogenated castor oil having an average addition mole number of EO of 40 to 100 mol desirable.

Concretely, commercially available products such as those shown below that are commercialized can be used.

Polyoxyethylene hydrogenated castor oil;

NIKKOL HCO series manufactured by Nikko Chemicals Co., Emarex HC series manufactured by Nippon Emulsion Co., Uniox HC series manufactured by Nippon Oil &

Polyoxyethylene alkyl ethers;

NIKKOL BC series manufactured by Nikko Chemicals Co., NIKKOL BS series, Emarex 100 series manufactured by Nihon Emulsion Co., Emarex 600 series

Decaglycerol mono fatty acid esters;

NIKKOL Decagln series manufactured by Nikko Chemicals Co., Ltd., Ryogo (registered trademark) polyglycol ester D series manufactured by Mitsubishi Chemical Foods Co.,

The blending amount of the nonionic surfactant as the component (C) is preferably from 0.1 to 2%, more preferably from 0.1 to 1%, and still more preferably from 0.2 to 0.5% based on the whole composition. When the content is 0.1% or more, sufficient precipitation inhibiting effect, crustal hypersensitivity inhibiting effect and floating bacteria germicidal effect are achieved, and the bitter taste can be sufficiently suppressed. 2% or less is more suitable for preventing the hypersensitivity inhibiting effect and the sterilizing effect of the floating bacteria from being deteriorated.

Examples of the amphoteric surfactant (D) include alkyl amide betaine or salts thereof such as palm oil fatty amide propylbetaine, betaine acetate type such as lauryldimethylaminoacetic acid betaine, N-fatty acid acyl-N-carboxymethyl- And amino acid types such as imidazoline type and N-fatty acid acyl-L-alginate salt, and the like, and they may be used alone or in combination of two or more. In particular, alkylamide beta Phosphorus or a salt thereof is preferable, and palm oil fatty amide propyl betaine is particularly suitable.

Specifically, commercially available products such as coconut oil fatty acid amide propyl betaine (TEGO Betaine CK OK (30% aqueous solution) manufactured by Degussa Corporation, Anichtor 5AB (30% aqueous solution) manufactured by Kao Corporation) and the like can be used.

The blending amount of the amphoteric surfactant as the component (D) is preferably from 0.1 to 2%, more preferably from 0.1 to 1%, and still more preferably from 0.2 to 0.5%, based on the whole composition. When the content is 0.1% or more, sufficient precipitation inhibiting effect, crustal hypersensitivity inhibiting effect and floating bacteria germicidal effect are achieved, and the bitter taste can be sufficiently suppressed. 2% or less is more suitable for preventing the hypersensitivity inhibiting effect and the sterilizing effect of the floating bacteria from being deteriorated.

The liquid oral composition of the present invention is characterized in that (E) the content of water, that is, the water content in the composition, is 55% or more and less than 92%, preferably 60% or more and 91% or less, more preferably 60% or more, % Or less. When the water content is within the above range, the insoluble precipitate can be inhibited from being precipitated, and a superior antihyperglycemic effect and a bitter taste suppressing effect can be imparted. If it is less than 55%, precipitation can not be inhibited and the effect of suppressing the hypersensitivity and the effect of sterilizing the floating bacteria are inferior. If it is more than 92%, the precipitation inhibiting effect is inferior, the perineal hypersensitivity inhibiting effect and the sterilizing effect of the floating bacteria are also inferior, and the bitter taste can not be suppressed.

In the present invention, the pH of the liquid oral composition is from 6.8 to less than 8.0, preferably from 6.8 to 7.8, more preferably from 6.8 to 7.5. Within this range, the precipitation inhibiting effect, the perineal hypersensitive inhibiting effect and the bitter taste suppressing effect are excellent. If the pH is less than 6.8 or the pH is 8.0 or more, precipitation can not be inhibited, and the effect of suppressing the hypersensitivity and the effect of sterilizing the floating bacteria are inferior.

The pH value was measured by using a pH meter (model number Hm-30S) manufactured by Doi Kagaku Kogyo Co., Ltd. immediately after preparation, and the value after 3 minutes at 25 캜 (the same applies hereinafter).

In the present invention, a known pH adjuster may be added to adjust the pH of the composition within the above range. For example, an alkali metal hydrogen phosphate such as sodium dihydrogenphosphate and an alkali metal hydroxide such as sodium hydroxide.

The liquid oral composition of the present invention is ethanol-free. Herein, " no ethanol blended " means that ethanol is not blended. However, in the liquid oral composition, there is a case where a trace amount of ethanol derived from the raw material is contained in the perfume blended in the composition. Therefore, It does not contain ethanol in addition to ethanol which is contained in a trace amount. In this case, the amount of ethanol in the composition is preferably 100 ppm or less, more preferably 50 ppm or less, further preferably 10 ppm or less, and 0 ppm in the composition.

In the present invention, precipitation of an insoluble precipitate is suppressed in the ethanol-free formulation, and an excellent inhibitory effect on hypersensitivity and a sterilization effect of a floating bacteria are achieved.

The liquid oral composition of the present invention is particularly suitable as a detergent. In addition to the above-mentioned components, other known components may be added to the composition of the present invention within a range that does not interfere with the effect of the present invention. Specifically, a wetting agent, a solvent and, if necessary, a sweetening agent, a coloring agent, an antiseptic, a fragrance, and an active ingredient are blended.

In the composition for liquid oral cavity, particularly, the cleansing agent, it is preferable that a solid component not to be solubilized by an abrasive or the like is not ordinarily compounded, but does not contain an abrasive.

As the surfactant, a surfactant other than the nonionic surfactant (C) and the amphoteric surfactant (D) may not be blended, but in the case of blending, 0.5% or less (0 to 0.5%), particularly 0.05 to 0.2% desirable.

Examples of the wetting agent include sugar alcohols such as sorbitol, and polyhydric alcohols such as glycerin and polyethylene glycol. The blending amount of these wetting agents is usually 1 to 40%, particularly 2 to 40%.

As the solvent, purified water is generally used, and the water content in the composition can be added within the above range. Further, lower monohydric alcohols having 1 to 3 carbon atoms such as ethanol, propylene glycol and the like may be blended.

As the sweetening agent, xylitol, maltitol, saccharin, sodium saccharin, stevioside, aspartame and the like can be mixed. As the coloring agent, a water-soluble coloring matter having high safety such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105 can be added. Examples of the preservative include paraoxybenzoic acid ester, benzoic acid and salts thereof.

Examples of the perfume include natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, time oil, sage oil, cardamon oil, rosemary oil, marzam oil, lemon oil, nutmeg oil, lavender oil, paracrine oil Methylene salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, lauric acid, lauric acid, A perfume ingredient contained in the natural essential oils such as citral, camphor, borneol, pinene, spilan tall and the like, and a perfume ingredient such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenyl, methyl anthranilate, Ethyl-p-menthane-3-carboxamide, menthyllactate, ethyleneglycol, ethyleneglycol, ethyleneglycol, trimethylolpropane, -l-menthyl carbonate and the like And furthermore it is also possible to use a flavoring agent such as apple, banana, strawberry, blueberry, melon, pitch, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt One or two or more kinds of combine flavors may be used in an amount of 0.00001 to 3% in the composition so long as they do not interfere with the effect of the present invention.

Examples of the active ingredient include, in addition to potassium nitrate and cetylpyridinium chloride, fungicides such as isopropylmethylphenol, antiinflammatory agents such as tranexamic acid and epsilon aminocaproic acid, enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate , Allantoin, vitamins such as vitamin C, copper compounds, and plant extracts. The amount of the active ingredient to be added may be within a range that does not hinder the effect of the present invention.

Example

Hereinafter, the present invention will be described in detail by way of examples, comparative examples, and formulations, but the present invention is not limited to the following examples. In the following examples,% represents mass% unless otherwise specified. The pH was measured at 25 캜 as described above.

[Practical example, comparative example]

A liquid oral composition (salve) having the compositions shown in Tables 1 and 2 was prepared by a routine method. The results are shown in Tables 1 and 2, with respect to the obtained curing agent, by the following methods and criteria.

(1) Evaluation method of appearance stability (precipitation inhibiting effect)

80 mL of each of the tax remedies listed in the table was placed in a 100 mL PET bottle and stored in a constant temperature bath at 25 ° C. The appearance after 4 weeks was judged visually according to the following criteria. The average value of 5 samples was obtained and evaluated according to the following evaluation criteria.

Rated by:

4 points: There was no precipitate

3 point: The precipitate was slightly

2 points: There were some precipitates

1 point: There was considerable precipitate

Evaluation criteria for appearance stability (precipitation inhibiting effect):

◎: Average point 3.5 or more and 4.0 or less

○: 3.0 points or more and less than 3.5 points

△: Average point of 2.0 points or more and less than 3.0 points

X: Average point less than 2.0 point

(2) Evaluation method of inhibiting the hypersensitive hypersensitivity

Each of the cigarette removers listed in the table was used for five months to dentine sensitive hypoglycemia for one month in a conventional manner, and the suppressive effect of the hypersensitivity was evaluated on the basis of the following criteria. The average value of 5 subjects was obtained and evaluated according to the following evaluation criteria.

Rating criteria for inhibiting the hypersensitivity:

3 points: I did not feel any pain

2 points: I almost did not feel any pain.

1 point: I feel pain

Evaluation criteria for inhibiting hypersensitivity:

◎: 2.5 points or more and 3.0 points or less

○: 2.0 points or more and less than 2.5 points

?: 1.5 or more and less than 2.0 points

×: less than 1.5 points

(3) Evaluation method of sterilization effect on airborne bacteria in oral cavity

The bacterial solution to be used was prepared by dissolving 30 g of a tryptic case soy broth (Difco) as a culture solution in 1 L of purified water to prepare a bacterial suspension containing 10 mg of Lactococcus mutans ATCC10449 Co., Ltd. as an oral bacterium , And was prepared by adding physiological saline so that the permeability (permeability) at 550 nm of the liquid cultured for 1 day under anaerobic conditions (5 volume% carbonic acid gas, 95 volume% nitrogen) was 20 at 37 ° C. 0.3 ml of the bacterial solution was added to 2.7 ml of the sample (liquid oral composition), and the mixture was stirred and reacted at 37 占 폚 for 1 minute. After stirring again, five test tubes containing 2.7 ml of the culture solution were prepared in advance, , 0.3 ml of the sample to which the bacterial solution was added was added and stirred. 0.3 ml of this solution was sampled, added to a second test tube, and stirred. This operation was likewise carried out successively in the third to fifth test tubes. The culture medium in the 1st, 3rd and 5th test tubes was stirred and then 50 쨉 l of a tryptic case soybean agar plate (Difco) containing 10% sheep desensitized blood was smoothed, Lt; / RTI > The grown colonies were counted and the viable cell count (cfu) of the remaining Leptococcus mutans bacteria was determined. The bactericidal effect of the floating bacteria was determined according to the following criteria.

Criteria :

&Amp; cir &: Less than 10 < ^{2 &}

○: Number of living cells 10 ² or more and less than 10 ³

?: The number of viable cells was 10 ³ or more and less than 10 ⁴

×: number of viable bacteria is 10 ⁴ or more

(4) Evaluation method of feelings (no bitterness)

Ten milliliters of each corticosteremic agent listed in the table was placed in the mouth and rinsed for 30 seconds. Five judges of the bitter taste after the cuffing were judged according to the following criteria. The average value of 5 persons was obtained and evaluated according to the following evaluation criteria.

Rated by:

4 points: There was no bitter taste.

3 points: Almost no bitter taste.

2 points: There was bitter taste.

1 point: There was a bitter taste.

Feeling of use (no bitterness after categorization) Evaluation criteria:

◎: Average point 3.5 or more and 4.0 or less

○: 3.0 points or more and less than 3.5 points

△: Average point of 2.0 points or more and less than 3.0 points

X: Average point less than 2.0 point

Details of the raw materials used are shown below.

(A) potassium nitrate; Potassium nitrate super tablet (manufactured by Otsuka Food Chemical Co., Ltd.)

(B) cetylpyridinium chloride; Cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.)

(C) polyoxyethylene (100) hardened castor oil;

Average addition mole number 100 of ethylene oxide (manufactured by Nikko Chemicals Co., Ltd.)

Polyoxyethylene (40) hardened castor oil;

Average addition mole number 40 of ethylene oxide (manufactured by Nikko Chemicals)

(D) alkylamide betaine;

30% aqueous solution of palm oil fatty amide propyl betaine, TEGO Betain CK OK (manufactured by Degussa)

Incidentally, the compounding amount of the alkylamide betaine in the tables is the net conversion value (the same applies hereinafter).

[Table 1]

[Table 2]

*; In the ethanol-blended composition of Comparative Example 8, there was no precipitation of insoluble precipitates, and the effect of suppressing the hypersensitivity and the sterilizing effect of the floating bacteria were not lowered even when the components (A) and (B) were blended.

Hereinafter, a prescription example is shown. The materials used are the same as above. These three remedies were all excellent in appearance stability (precipitation inhibiting effect), retarding hypersensitivity effect, sterilizing effect of floating bacteria, and feeling of use (no bitter taste).

[Prescription]

(A) Potassium nitrate 5.0%

(B) cetylpyridinium chloride 0.05

(C) Polyoxyethylene (60) Hardened castor oil 0.5

(D) Alkyl amide betaine 0.3

Glycerin 3.0

Propylene glycol 8.0

Sodium saccharin 0.1

Sodium dihydrogen phosphate 0.5

Sodium hydroxide 0.16

Fragrance 0.2

(E) Purified water  82.19

Total 100.0%

pH 6.8

Claims (9)

(C) a nonionic surfactant and (D) an amphoteric surfactant in an ethanol-free liquid oral composition containing (A) potassium nitrate and (B) cetylpyridinium chloride, By mass to less than 92% by mass, and the pH of the composition is set to 6.8 or more and less than 8.0. The method according to claim 1,
(C) the nonionic surfactant is a polyoxyethylene hardened castor oil, and (D) the amphoteric surfactant is an alkylamide betaine or a salt thereof. 3. The method according to claim 1 or 2,
(C) the nonionic surfactant is polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, and (D) the amphoteric surfactant is palm oil fatty acid amide propyl betaine. Composition. 4. The method according to any one of claims 1 to 3,
, 0.1 to 2 mass% of component (C), and 0.1 to 2 mass% of component (D). 5. The method according to any one of claims 1 to 4,
0.01 to 10 mass% of component (A) and 0.001 to 0.1 mass% of component (B). 6. The method according to any one of claims 1 to 5,
Or a salt thereof. 7. The method according to any one of claims 1 to 6,
Wherein the composition is for inhibiting hypersensitivity and dental caries. (C) a nonionic surfactant and (D) an amphoteric surfactant in an ethanol-free liquid oral composition containing (A) potassium nitrate and (B) cetylpyridinium chloride, (A) nitric acid potassium and (B) cetylpyridinium chloride in the liquid oral composition, wherein the composition has a pH of not less than 92 mass% and a pH of the composition of not less than 6.8 and less than 8.0. A method for inhibiting precipitation of insoluble precipitates. A method for inhibiting the precipitation of an insoluble precipitate caused by the combined use of (A) potassium nitrate and (B) cetylpyridinium chloride in the liquid oral composition according to claim 8, wherein the liquid oral composition is a three-part cleansing agent.