JP6688072B2 - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
- Publication number
- JP6688072B2 JP6688072B2 JP2015256172A JP2015256172A JP6688072B2 JP 6688072 B2 JP6688072 B2 JP 6688072B2 JP 2015256172 A JP2015256172 A JP 2015256172A JP 2015256172 A JP2015256172 A JP 2015256172A JP 6688072 B2 JP6688072 B2 JP 6688072B2
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- mass
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- oil
- liquid oral
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- 239000000203 mixture Substances 0.000 title claims description 71
- 239000007788 liquid Substances 0.000 title claims description 69
- 210000000214 mouth Anatomy 0.000 claims description 30
- 239000006260 foam Substances 0.000 claims description 20
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 239000002736 nonionic surfactant Substances 0.000 claims description 15
- -1 alkyl betaine Chemical compound 0.000 claims description 14
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 claims description 10
- 229960003237 betaine Drugs 0.000 claims description 10
- 239000002304 perfume Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 8
- 239000002280 amphoteric surfactant Substances 0.000 claims description 8
- 235000019864 coconut oil Nutrition 0.000 claims description 7
- 239000003240 coconut oil Substances 0.000 claims description 7
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 7
- 239000000194 fatty acid Substances 0.000 claims description 7
- 229930195729 fatty acid Natural products 0.000 claims description 7
- 150000004665 fatty acids Chemical class 0.000 claims description 7
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 6
- 229960003500 triclosan Drugs 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 claims description 4
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 claims description 4
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- 239000003205 fragrance Substances 0.000 description 24
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- CFAKWWQIUFSQFU-UHFFFAOYSA-N 2-hydroxy-3-methylcyclopent-2-en-1-one Chemical compound CC1=C(O)C(=O)CC1 CFAKWWQIUFSQFU-UHFFFAOYSA-N 0.000 description 2
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
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- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
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- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
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- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 2
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 2
- MLFHJEHSLIIPHL-UHFFFAOYSA-N isoamyl acetate Chemical compound CC(C)CCOC(C)=O MLFHJEHSLIIPHL-UHFFFAOYSA-N 0.000 description 2
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- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
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- 239000001627 myristica fragrans houtt. fruit oil Substances 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
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- 239000010678 thyme oil Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
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- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、液体口腔用組成物に関する。 The present invention relates to liquid oral compositions.
従来より、歯面に付着した歯垢又は歯石の除去効果や、う蝕防止効果、着色汚れの除去効果等、種々の性能を発揮し得る液体口腔用組成物が開発されている。例えば、特許文献1には、pHが8以上12以下であるアルカリ性の口腔洗浄剤が開示されており、かかる洗浄剤が高いバイオフィルムの除去効果を発揮している。このように、アルカリ性領域であれば、歯垢又は歯石の除去やバイオフィルムの除去等、口腔内における洗浄性能を高めることができる。 BACKGROUND ART Conventionally, a liquid composition for oral cavity has been developed which can exhibit various properties such as an effect of removing plaque or tartar attached to a tooth surface, an effect of preventing dental caries, an effect of removing colored stains, and the like. For example, Patent Document 1 discloses an alkaline mouthwash having a pH of 8 or more and 12 or less, and such a detergent exhibits a high biofilm removal effect. Thus, in the alkaline region, the cleaning performance in the oral cavity such as removal of plaque or tartar and removal of biofilm can be enhanced.
一方、液体口腔用組成物に香料を配合する際、かかる香料の溶解又は分散を促進するうえで、一般にはポリオキシエチレン硬化ヒマシ油等のノニオン界面活性剤が用いられている。例えば、かかるノニオン界面活性剤や香料に加え、特許文献2には、イミダゾリニウムベタイン型等の両性界面活性剤等を含む泡状口腔用組成物が開示されている。また、特許文献3には、カルボン酸型両性界面活性剤等を含む泡沫状となる口腔用組成物が開示されており、pHを3〜9の範囲に調整することも記載されている。 On the other hand, when blending a fragrance into a liquid oral composition, a nonionic surfactant such as polyoxyethylene hydrogenated castor oil is generally used to accelerate the dissolution or dispersion of the fragrance. For example, Patent Document 2 discloses a foamy oral composition containing an amphoteric surfactant such as an imidazolinium betaine type in addition to the nonionic surfactant and the fragrance. Further, Patent Document 3 discloses a foamy oral composition containing a carboxylic acid type amphoteric surfactant and the like, and also describes adjusting the pH to a range of 3 to 9.
しかしながら、こうしたポリオキシエチレン硬化ヒマシ油等のノニオン界面活性剤は、アルカリ性領域においては、エステル結合が加水分解されることが知られており、また、ポリオキシエチレン鎖を有する界面活性剤は溶解し難くなることも知られているだけでなく、風味が低下するおそれもある。そのため、口腔内における洗浄性能を高めるべく、液体口腔用組成物をアルカリ性領域に調整しつつ、香料の含有量を増大させようとするにあたり、上記特許文献2〜3の組成物では、いずれも香料や併用する界面活性剤の量的関係に関する検討が不十分であるため、ノニオン界面活性剤の安定性が損なわれて香料を良好に溶解又は分散させることが困難となり、依然として改善の余地がある。 However, in nonionic surfactants such as polyoxyethylene hydrogenated castor oil, it is known that the ester bond is hydrolyzed in the alkaline region, and the surfactant having a polyoxyethylene chain is not dissolved. Not only is it known to be difficult, but the flavor may be reduced. Therefore, in order to increase the content of the perfume while adjusting the liquid oral composition to the alkaline region in order to enhance the cleaning performance in the oral cavity, in the compositions of Patent Documents 2 to 3 described above, all of the perfume are perfume. Since the study on the quantitative relationship between the surfactants used in combination with the above is insufficient, the stability of the nonionic surfactant is impaired, and it becomes difficult to dissolve or disperse the fragrance well, and there is still room for improvement.
したがって、本発明は、洗浄性能が高められるアルカリ性領域でありながら、安定かつ充分な量で香料を含有することのできる液体口腔用組成物に関する。 Therefore, the present invention relates to a liquid oral composition capable of containing a fragrance in a stable and sufficient amount in an alkaline region where the cleaning performance is enhanced.
そこで本発明者らは、種々検討したところ、香料と両性界面活性剤とを特定の量比としつつ、ノニオン界面活性剤を両性界面活性剤に対して特定の量で用いることにより、アルカリ性領域であっても、充分な量の香料を安定に含有することのできる液体口腔用組成物が得られることを見出した。 Therefore, the present inventors have made various studies, and while using a specific amount ratio of the fragrance and the amphoteric surfactant, by using the nonionic surfactant in a specific amount with respect to the amphoteric surfactant, in the alkaline region Even if it exists, it has been found that a liquid oral composition capable of stably containing a sufficient amount of perfume can be obtained.
すなわち、本発明は、次の成分(A)、(B)、及び(C):
(A)両性界面活性剤、
(B)香料 0.2質量%以上1.5質量%以下(b−1)のみ、或いは
香料 0.2質量%以上1.5質量%以下(b−1)と、トリクロサン、イソプロピルメチルフェノール、β−グリチルレチン酸、及びアズレンから選ばれる1種又は2種以上の油溶性薬効成分(b−2)、
(C)水 55質量%以上98質量%以下
を含有し、ノニオン界面活性剤の含有量が成分(A)の含有量に対して1倍未満であり、成分(b−1)と成分(A)との質量比((b−1)/(A))が0.1以上1.7以下であり、成分(B)が成分(b−2)を含む場合における成分(b−2)と成分(A)との質量比((b−2)/(A))が0.005以上0.2以下であり、かつ
25℃におけるpHが8以上11以下である液体口腔用組成物に関する。
That is, the present invention provides the following components (A), (B), and (C):
(A) Amphoteric surfactant,
(B) Perfume 0.2 mass% or more and 1.5 mass% or less (b-1) only, or perfume 0.2 mass% or more and 1.5 mass% or less (b-1), triclosan, isopropylmethylphenol, β-glycyrrhetinic acid, and one or more oil-soluble medicinal components (b-2) selected from azulene,
(C) Water contains 55% by mass or more and 98% by mass or less, the content of the nonionic surfactant is less than 1 time the content of the component (A), and the components (b-1) and (A) In the case where the mass ratio ((b-1) / (A)) is 0.1 or more and 1.7 or less and the component (B) contains the component (b-2), The present invention relates to a liquid oral composition having a mass ratio ((b-2) / (A)) of component (A) of 0.005 or more and 0.2 or less and a pH at 25 ° C of 8 or more and 11 or less.
本発明の液体口腔用組成物によれば、25℃におけるpHが8以上11以下なるアルカリ性領域であっても、製造直後から低温保存後に至るまで、充分な量の香料を安定に含有することができる。また、こうした良好な安定性を確保したまま特定の油溶性薬効成分も含有することができ、所望の薬効も作用させることが可能であるとともに、透明性又は半透明性の外観を付与することも可能である。 According to the liquid oral composition of the present invention, a sufficient amount of fragrance can be stably contained from immediately after production to after low-temperature storage even in an alkaline region where the pH at 25 ° C. is 8 or more and 11 or less. it can. Further, it is possible to contain a specific oil-soluble medicinal component while ensuring such good stability, and it is possible to act a desired medicinal effect, and also to impart a transparent or translucent appearance. It is possible.
以下、本発明について詳細に説明する。
本発明の液体口腔用組成物は、成分(A)として、両性界面活性剤を含有する。かかる成分(A)を含有し、かつ後述するように成分(A)とノニオン界面活性剤や成分(B)とが特定の量的関係を有することにより、製造直後から低温保存後に至るまで、成分(B)を充分な量で良好に溶解又は分散させつつ、高い安定性を確保することができる。
Hereinafter, the present invention will be described in detail.
The liquid composition for oral cavity of the present invention contains an amphoteric surfactant as the component (A). Since the component (A) contains the component (A) and the component (A) and the nonionic surfactant or the component (B) have a specific quantitative relationship as described below, the component can be used immediately after production until after low temperature storage. High stability can be secured while satisfactorily dissolving or dispersing (B) in a sufficient amount.
成分(A)の両性界面活性剤としては、ラウリルジメチルアミノ酢酸ベタイン等の酢酸ベタイン;2−アルキル−N−カルボキシメチル−N−ヒドロキシエチル−N−イミダゾリウムベタイン等のイミダゾリニウムベタイン;ラウリルスルホベタインやラウリルヒドロキシスルホベタイン等のアルキルスルホベタイン;ヤシ油脂肪酸アミドプロピルベタイン等のヤシ油脂肪酸アミドアルキルベタイン;N−アルキル−1−ヒドロキシエチルイミダゾリンベタインナトリウム等の長鎖アルキルイミダゾリンベタイン塩から選ばれる1種又は2種以上が挙げられる。なかでも、低温での析出物の発生を効果的に抑制する観点、及び使用感の観点から、ヤシ油脂肪酸アミドアルキルベタイン、及びアルキルスルホベタインから選ばれる1種又は2種以上が好ましく、ヤシ油脂肪酸アミドアルキルベタインがより好ましく、アルキルの炭素数が2〜5であるヤシ油脂肪酸アミドアルキルベタインがさらに好ましく、ヤシ油脂肪酸アミドプロピルベタインがよりさらに好ましい。 As the amphoteric surfactant of the component (A), betaine acetate such as lauryldimethylaminoacetic acid betaine; imidazolinium betaine such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; laurylsulfo 1 selected from alkylsulfobetaines such as betaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amide alkylbetaines such as coconut oil fatty acid amide propyl betaine; long-chain alkylimidazoline betaine salts such as N-alkyl-1-hydroxyethylimidazoline betaine sodium Or two or more species. Among them, from the viewpoint of effectively suppressing the generation of precipitates at low temperatures, and from the viewpoint of feeling of use, one or more selected from coconut oil fatty acid amide alkylbetaine and alkylsulfobetaine are preferable, and coconut oil Fatty acid amide alkyl betaine is more preferable, coconut oil fatty acid amide alkyl betaine in which the alkyl has 2 to 5 carbon atoms is further preferable, and coconut oil fatty acid amide propyl betaine is even more preferable.
成分(A)の含有量は、ノニオン界面活性剤の含有量が制限されるpHがアルカリ性の液体口腔用組成物においても香料を良好に溶解又は分散させる観点から、本発明の液体口腔用組成物中に、好ましくは0.2質量%以上であり、低温での析出物の発生を有効に抑制する観点、及び低温保存後においても高い安定性を保持する観点から、より好ましくは0.3質量%以上であり、さらに好ましくは0.4質量%以上である。また、成分(A)の含有量は、良好な使用感を確保する観点から、本発明の液体口腔用組成物中に、好ましくは1.5質量%以下であり、より好ましくは1.2質量%以下であり、さらに好ましくは1質量%以下である。そして、成分(A)の含有量は、本発明の液体口腔用組成物中に、好ましくは0.2〜1.5質量%であり、より好ましくは0.3〜1.2質量%であり、さらに好ましくは0.4〜1質量%である。 The content of the component (A) is the liquid oral composition of the present invention from the viewpoint of satisfactorily dissolving or dispersing the fragrance even in a liquid oral composition having an alkaline pH in which the content of the nonionic surfactant is limited. It is preferably 0.2% by mass or more, and more preferably 0.3% by mass from the viewpoint of effectively suppressing the generation of precipitates at low temperature and maintaining high stability even after storage at low temperature. % Or more, and more preferably 0.4% by mass or more. Further, the content of the component (A) is preferably 1.5% by mass or less, more preferably 1.2% by mass in the composition for liquid oral cavity of the present invention, from the viewpoint of ensuring a good feeling in use. % Or less, and more preferably 1% by mass or less. The content of the component (A) in the liquid oral composition of the present invention is preferably 0.2 to 1.5% by mass, more preferably 0.3 to 1.2% by mass. , And more preferably 0.4 to 1% by mass.
本発明の液体口腔用組成物は、成分(B)として、香料を0.2質量%以上1.5質量%以下(b−1)のみ含有するか、或いは香料を0.2質量%以上1.5質量%以下(b−1)と、トリクロサン、イソプロピルメチルフェノール、β−グリチルレチン酸、及びアズレンから選ばれる1種又は2種以上の油溶性薬効成分(b−2)とを含有する。すなわち、本発明の液体口腔用組成物中において、成分(b−1)の香料は、特定の油溶性薬効成分である成分(b−2)を含有するか否かにかかわらず、後述する成分(b−1)と成分(A)との間で特定の質量比を有することとも相まって、常に0.2質量%以上1.5質量%以下もの高含有量でありながら、良好に溶解又は分散している。 The liquid oral composition of the present invention contains, as the component (B), only 0.2% by mass or more and 1.5% by mass or less (b-1) of a fragrance, or 0.2% by mass or more and 1% of a fragrance. 0.5 mass% or less (b-1) and one or more oil-soluble medicinal components (b-2) selected from triclosan, isopropylmethylphenol, β-glycyrrhetinic acid, and azulene are contained. That is, in the liquid composition for oral cavity of the present invention, the fragrance of the component (b-1) is a component described below regardless of whether it contains the component (b-2) which is a specific oil-soluble medicinal component. In combination with having a specific mass ratio between (b-1) and component (A), the content is always as high as 0.2% by mass or more and 1.5% by mass or less, but is well dissolved or dispersed. is doing.
香料(b−1)としては、ペパーミント油、スペアミント油、シナモン油、アニス油、ユーカリ油、ウィンターグリーン油、カシア油、クローブ油、タイム油、セージ油、セージクラリー油、ナツメグ油、ファンネル油、レモン油、オレンジ油、ハッカ油、カルダモン油、コリアンダー油、バジル油、マンダリン油、ライム油、ラベンダー油、ローズマリー油、ジンジャ−油、グレープフルーツ油、ローレル油、カモミル油、キャラウェイ油、マジョラム油、ベイ油、レモングラス油、レモンバーム油、ピメントベリー油、パルマローザ油、オリバナム油、パインニードル油、ペチグレン油、ネロリ油、ローズ油、ジャスミン油等の天然香料成分、及びこれら天然香料成分を加工処理した香料成分;メントール、プレトール、カルボン、アネトール、シネオール、サリチル酸メチル、シンナミックアルデヒド、オイゲノール、3−1−メントキシプロパン−1,2−ジオール、チモール、シトロネリルアセテート、リナロール、リナリルアセテート、ゲラニオール、ゲラニルアセテート、シトロネロール、リモネン、メントン、メンチルアセテート、N−置換−パラメンタン−3−カルボキサミド、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビルアセテート、ジヒドロカルビルアセテート、アニスアルデヒド、ベンズアルデヒド、カンファー、ラクトン、エチルアセテート、エチルブチレート、アリルシクロヘキシルプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、バニリン、ウンデカラクトン、ヘキサナール、ブチルアセテート、イソアミルアセテート、ヘキセノール、ジメチルサルファイド、シクロテン、フルフラール、トリメチルピラジン、エチルラクテート、メチルラクテート、エチルチオアセテート等の単品香料成分;ストロベリーフレーバー、アップルフレーバー、バナナフレーバー、パイナップルフレーバー、グレープフレーバー、マンゴーフレーバー、バターフレーバー、ミルクフレーバー、フルーツミックスフレーバー、トロピカルフルーツフレーバー等の調合香料成分が挙げられる。 Examples of the fragrance (b-1) are peppermint oil, spearmint oil, cinnamon oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, sage clary oil, nutmeg oil, funnel oil, Lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, basil oil, mandarin oil, lime oil, lavender oil, rosemary oil, ginger oil, grapefruit oil, laurel oil, chamomile oil, caraway oil, marjoram oil. Processing natural fragrance ingredients such as bay oil, lemongrass oil, lemon balm oil, pimento berry oil, palmarosa oil, olibanum oil, pine needle oil, petiglene oil, neroli oil, rose oil, jasmine oil, and these natural fragrance ingredients Fragrance ingredients: menthol, pretol, carvone, rape , Cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, citronellyl acetate, linalool, linalyl acetate, geraniol, geranyl acetate, citronellol, limonene, menthone, Menthyl acetate, N-substituted paramenthane-3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, dihydrocarbyl acetate, anisaldehyde, benzaldehyde, camphor, lactone, ethyl acetate, ethyl butyrate, allyl cyclohexyl propio Nate, methyl anthranilate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, butyl acetate Fragrance ingredients such as isoamyl acetate, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioacetate; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor. Formulated perfume ingredients such as milk flavor, fruit mix flavor, tropical fruit flavor, and the like.
成分(b−1)の含有量は、本発明の液体口腔用組成物がアルカリ性であっても、良好な香味等をもたらしつつ溶解性又は分散性を確保する観点から、本発明の液体口腔用組成物中に、0.2質量%以上であって、好ましくは0.3質量%以上であり、例えば泡吐出容器から吐出された泡状の液体口腔用組成物であっても香味を有効に感じさせる観点から、より好ましくは0.4質量%以上であり、1.5質量%以下であって、好ましくは1.2質量%以下であり、さらに好ましくは1質量%以下である。そして、成分(b−1)の含有量は、0.2質量%以上1.5質量%以下であって、好ましくは0.3〜1.2質量%であり、より好ましくは0.4〜1質量%である。 The content of the component (b-1) is for the liquid oral cavity of the present invention from the viewpoint of ensuring solubility or dispersibility while providing a good flavor even if the liquid oral cavity composition of the present invention is alkaline. It is 0.2% by mass or more, preferably 0.3% by mass or more in the composition, and even if it is a foamy liquid oral composition discharged from a foam discharge container, the flavor is effectively provided. From the viewpoint of feeling, the content is more preferably 0.4% by mass or more, 1.5% by mass or less, preferably 1.2% by mass or less, and further preferably 1% by mass or less. The content of the component (b-1) is 0.2% by mass or more and 1.5% by mass or less, preferably 0.3 to 1.2% by mass, and more preferably 0.4 to It is 1% by mass.
成分(b−1)と成分(A)との質量比((b−1)/(A))は、成分(b−1)の良好な香味等をもたらす観点から、0.1以上であって、好ましくは0.2以上であり、より好ましくは0.3以上であり、さらに良好な香味等をもたらす観点から、好ましくは0.4以上であり、成分(b−1)を良好に溶解又は分散させる観点から、1.7以下であって、好ましくは1.5以下であり、低温での析出物の発生を有効に抑制する観点、及び低温保存後においても高い安定性を保持する観点から、より好ましくは1.2以下であり、よりさらに好ましくは1以下である。そして、成分(b−1)と成分(A)との質量比((b−1)/(A))は、0.1以上1.7以下であって、好ましくは0.2〜1.5であり、良好な香味等をもたらしつつ低温での析出物の発生を有効に抑制する観点、及び低温保存後においても高い安定性を保持する観点から、より好ましくは0.3〜1.2であり、さらに好ましくは0.4〜1である。 The mass ratio ((b-1) / (A)) of the component (b-1) and the component (A) is 0.1 or more from the viewpoint of providing a good flavor and the like of the component (b-1). It is preferably 0.2 or more, more preferably 0.3 or more, and more preferably 0.4 or more from the viewpoint of providing a good flavor and the like, and dissolves the component (b-1) well. Or from the viewpoint of dispersion, it is 1.7 or less, preferably 1.5 or less, the viewpoint of effectively suppressing the generation of precipitates at low temperatures, and the viewpoint of maintaining high stability even after storage at low temperatures. Therefore, it is more preferably 1.2 or less, still more preferably 1 or less. The mass ratio ((b-1) / (A)) of the component (b-1) and the component (A) is 0.1 or more and 1.7 or less, preferably 0.2 to 1. 5, more preferably 0.3 to 1.2 from the viewpoint of effectively suppressing the generation of precipitates at low temperature while providing a good flavor and the like, and from the viewpoint of maintaining high stability even after storage at low temperature. And more preferably 0.4 to 1.
本発明の液体口腔用組成物は、成分(B)として、成分(b−1)の香料とともに、トリクロサン、イソプロピルメチルフェノール、β−グリチルレチン酸、及びアズレンから選ばれる1種又は2種以上の油溶性薬効成分(b−2)を含有することができる。本発明の液体口腔用組成物であれば、製造直後から低温保存後に至るまで、充分な量の成分(b−1)を安定に含有することができるため、後述する成分(b−2)と成分(A)との間で特定の質量比を有することとも相まって、上記特定の油溶性薬効成分である成分(b−2)をも安定に含有して所望の薬効を得ることができる。成分(b−2)の油溶性薬効成分は、低温保存後の安定性の観点から、トリクロサン、β−グリチルレチン酸、及びアズレンから選ばれる1種又は2種以上であることが好ましく、トリクロサン及びβ−グリチルレチン酸から選ばれる1種又は2種であることがさらに好ましく、β−グリチルレチン酸であることが好ましい。 The liquid oral composition of the present invention comprises, as the component (B), one or more oils selected from triclosan, isopropylmethylphenol, β-glycyrrhetinic acid, and azulene together with the fragrance of the component (b-1). A soluble drug component (b-2) can be contained. Since the liquid composition for oral cavity of the present invention can stably contain a sufficient amount of the component (b-1) from immediately after the production to after the low temperature storage, the component (b-2) described later and Coupled with having a specific mass ratio with the component (A), the specific oil-soluble drug component (b-2), which is the specific oil-soluble drug component, can also be stably contained to obtain a desired drug effect. From the viewpoint of stability after low-temperature storage, the oil-soluble drug component of component (b-2) is preferably one or more selected from triclosan, β-glycyrrhetinic acid, and azulene, and triclosan and β More preferably, it is one or two selected from glycyrrhetinic acid, and is preferably β-glycyrrhetinic acid.
このように、成分(B)が成分(b−1)とともに成分(b−2)を含む場合における、成分(b−2)と成分(A)との質量比((b−2)/(A))は、成分(b−2)の有効性を確保する観点から、0.005以上であって、好ましくは0.01以上であり、より好ましくは0.02以上であり、さらに好ましくは0.03以上である。また、成分(b−2)と成分(A)との質量比((b−2)/(A))は、成分(b−1)と成分(b−2)の双方の溶解性又は分散性を確保する観点から、0.2以下であって、好ましくは0.15以下であり、より好ましくは0.1以下である。そして、成分(b−2)と成分(A)との質量比((b−2)/(A))は、0.005以上0.2以下であって、好ましくは0.01〜0.15であり、より好ましくは0.02〜0.1であり、さらに好ましくは0.03〜0.1である。 Thus, when the component (B) contains the component (b-1) together with the component (b-1), the mass ratio of the component (b-2) and the component (A) ((b-2) / ( A)) is 0.005 or more, preferably 0.01 or more, more preferably 0.02 or more, and further preferably from the viewpoint of ensuring the effectiveness of the component (b-2). It is 0.03 or more. Further, the mass ratio ((b-2) / (A)) of the component (b-2) and the component (A) is the solubility or dispersion of both the component (b-1) and the component (b-2). From the viewpoint of securing the property, it is 0.2 or less, preferably 0.15 or less, and more preferably 0.1 or less. The mass ratio ((b-2) / (A)) of the component (b-2) and the component (A) is 0.005 or more and 0.2 or less, preferably 0.01 to 0. It is 15, more preferably 0.02-0.1, still more preferably 0.03-0.1.
本発明の液体口腔用組成物において、ノニオン界面活性剤の含有量は、成分(A)の含有量に対して1倍以下である。このように、成分(A)の含有量に対してノニオン界面活性剤の含有を制限することにより、アルカリ性領域においてエステル結合が加水分解されることが知られており、また、ポリオキシエチレン鎖を有する界面活性剤は溶解し難くなることが知られているノニオン界面活性剤に左右されることなく、製造直後から低温保存後に至るまで充分な量の成分(b−1)を安定に含有させることができる。 In the liquid composition for oral cavity of the present invention, the content of the nonionic surfactant is not more than 1 time the content of the component (A). Thus, it is known that the ester bond is hydrolyzed in the alkaline region by limiting the content of the nonionic surfactant with respect to the content of the component (A). It is known that the surfactant has a stable amount of the component (b-1) from immediately after production to after low-temperature storage without being affected by the nonionic surfactant which is known to be difficult to dissolve. You can
ノニオン界面活性剤の含有量は、アルカリ性領域におけるエステル結合の加水分解を抑制し、界面活性剤の溶解性の低下を抑制し、或いは成分(b−1)を良好に溶解又は分散を向上させる観点から、成分(A)の含有量に対して1倍未満であって、好ましくは0.5倍以下であり、成分(b-2)の口腔内の粘膜や歯肉等への吸着性を高める観点から、より好ましくは0.2倍以下である。また、ノニオン界面活性剤の含有量は、同様の観点から、本発明の液体口腔用組成物中に、好ましくは1質量%以下であり、より好ましくは0.5質量%以下であり、さらに好ましくは0.2質量%以下であり、よりさらに好ましくは0.1質量%以下であり、或いは本発明の液体口腔用組成物は、ノニオン界面活性剤を含有しないのが好ましい。 The content of the nonionic surfactant is such that the hydrolysis of the ester bond in the alkaline region is suppressed, the decrease in the solubility of the surfactant is suppressed, or the component (b-1) is favorably dissolved or dispersed. From the viewpoint of increasing the adsorptivity of the component (b-2) to the mucous membrane in the oral cavity, gingiva, etc., it is less than 1 time, preferably 0.5 times or less, the content of the component (A). Therefore, it is more preferably 0.2 times or less. From the same viewpoint, the content of the nonionic surfactant in the liquid oral composition of the present invention is preferably 1% by mass or less, more preferably 0.5% by mass or less, and further preferably Is 0.2% by mass or less, more preferably 0.1% by mass or less, or the liquid oral composition of the present invention preferably contains no nonionic surfactant.
本発明の液体口腔用組成物は、成分(C)として、水を55質量%以上98質量%以下含有する。本発明における成分(C)の水とは、液体口腔用組成物に配合した精製水やイオン交換水等だけでなく、配合した各成分に含まれる水分をも含む、液体口腔用組成物中に含まれる全水分を意味する。かかる成分(C)の水を含有することにより、各成分を良好に分散又は溶解させて口腔内で良好に拡散させつつ、良好な外観と使用感を保持することができる。 The liquid composition for oral cavity of the present invention contains 55% by mass or more and 98% by mass or less of water as the component (C). The water as the component (C) in the present invention means not only purified water and ion-exchanged water mixed in the liquid oral composition, but also water contained in each of the mixed components in the liquid oral composition. Means total water content. By containing such component (C), water, each component can be dispersed or dissolved well and diffused well in the oral cavity, while maintaining a good appearance and feeling of use.
成分(C)の含有量は、良好な外観と使用感を確保する観点から、本発明の液体口腔用組成物中に、55質量%以上であって、好ましくは60質量%以上であり、より好ましくは65質量%以上である。また、成分(C)の含有量は、良好な外観と使用感を確保する観点、本発明の液体口腔用組成物を泡吐出容器に充填した際に、良好な泡質と容器からの吐出性を保持する観点、及び本発明の液体口腔用組成物が成分(b−2)を含有する場合には、かかる成分(b−2)の口腔内での吸着性を高める観点から、本発明の液体口腔用組成物中に、98質量%以下であって、好ましくは90質量%以下であり、より好ましくは85質量%以下である。そして、成分(C)の含有量は、本発明の泡吐出容器入り液体口腔用組成物中に、55質量%以上98質量%以下であって、好ましくは60〜90質量%であり、より好ましくは65〜85質量%である。 The content of the component (C) in the liquid oral composition of the present invention is 55% by mass or more, preferably 60% by mass or more, from the viewpoint of ensuring a good appearance and a feeling of use. It is preferably 65% by mass or more. In addition, the content of the component (C) is from the viewpoint of ensuring a good appearance and feeling of use, when the liquid composition for oral cavity of the present invention is filled in a foam discharge container, good foam quality and dischargeability from the container are obtained. Of the present invention, and from the viewpoint of increasing the adsorptivity of the component (b-2) in the oral cavity, when the composition for a liquid oral cavity of the present invention contains the component (b-2). In the composition for liquid oral cavity, it is 98 mass% or less, preferably 90 mass% or less, more preferably 85 mass% or less. And the content of the component (C) is 55% by mass or more and 98% by mass or less, preferably 60 to 90% by mass, more preferably in the liquid composition for a liquid oral cavity containing a foam discharge container of the present invention. Is 65 to 85 mass%.
本発明の液体口腔用組成物は、泡吐出容器に充填した際に良好な吐出性を保持する観点から、20℃において液体のポリオール(D)を含有するのが好ましい。かかる成分(D)としては、例えば、グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上が挙げられる。なかでも、グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる2種以上のポリオールを用いるのが好ましく、グリセリン、プロピレングリコール、及びブチレングリコールから選ばれる1種又は2種以上を用いることが好ましく、グリセリン、及びプロピレングリコールから選ばれる1種又は2種を用いることが好ましい。なお、上記ポリエチレングリコールの平均分子量とは、GPC(ゲルパーミェーションクロマトグラフィ)により測定される質量平均分子量を意味する。
成分(D)として用いるポリエチレングリコールの質量平均分子量は、本発明の液体口腔用組成物を泡吐出容器に充填した際、泡吐出容器の多孔質部材の目詰まりを有効に防止する観点から、1000以下であって、好ましくは850以下であり、良好な泡質の観点から、好ましくは200以上であり、より好ましくは400以上である。
The liquid composition for oral cavity of the present invention preferably contains a liquid polyol (D) at 20 ° C. from the viewpoint of maintaining good dischargeability when filled in a foam discharge container. Examples of the component (D) include one or more selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 1,000 or less. Among them, it is preferable to use two or more kinds of polyols selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 1,000 or less, and one or more kinds selected from glycerin, propylene glycol, and butylene glycol. Is preferably used, and it is preferable to use one or two selected from glycerin and propylene glycol. The average molecular weight of the polyethylene glycol means a mass average molecular weight measured by GPC (gel permeation chromatography).
The weight average molecular weight of the polyethylene glycol used as the component (D) is 1000 from the viewpoint of effectively preventing clogging of the porous member of the foam discharge container when the liquid composition for oral cavity of the present invention is filled in the foam discharge container. Or less, preferably 850 or less, and from the viewpoint of good foam quality, it is preferably 200 or more, more preferably 400 or more.
成分(D)の含有量は、泡吐出容器に充填した際に良好な吐出性を保持する観点から、本発明の液体口腔用組成物中に、好ましくは10質量%以上であり、より好ましくは15質量%以上であり、低温における粘度上昇を抑制する観点から、好ましくは35質量%以下であり、より好ましくは32質量%以下である。なお、平均分子量1000以下のポリエチレングリコールの含有量は、低温における粘度上昇を抑制する観点から、本発明の液体口腔用組成物中に、好ましくは7質量%以下であり、より好ましくは5質量%以下であり、さらに好ましくは2質量%以下であり、含有しないものであってもよい。 The content of the component (D) is preferably 10% by mass or more, and more preferably in the liquid oral cavity composition of the present invention, from the viewpoint of maintaining good dischargeability when filled in a foam discharge container. It is 15% by mass or more, preferably 35% by mass or less, and more preferably 32% by mass or less from the viewpoint of suppressing the increase in viscosity at low temperature. The content of polyethylene glycol having an average molecular weight of 1,000 or less is preferably 7% by mass or less, and more preferably 5% by mass in the composition for liquid oral cavity of the present invention, from the viewpoint of suppressing increase in viscosity at low temperature. It is below, more preferably 2% by mass or less, and may not be contained.
本発明の液体口腔用組成物において、成分(b−1)による良好な香味等を確保しつつ、刺激性を低減する観点から、エタノールの含有を制限するのが好ましく、エタノールの含有を制限しても各成分の溶解性又は分散性を確保することができる。かかるエタノールの含有量は、成分(b−1)の含有量に対し、好ましくは15倍以下であり、より好ましくは10倍以下であり、さらに好ましくは5倍以下であり、3倍以下であってもよい。また、エタノールの含有量は、同様の観点から、本発明の液体口腔用組成物中に、好ましくは8質量%以下であり、より好ましくは5質量%以下であり、さらに好ましくは3質量%以下であり、或いは本発明の液体口腔用組成物は、エタノールを含有しないのが好ましい。 In the liquid oral composition of the present invention, it is preferable to limit the content of ethanol from the viewpoint of reducing irritation while ensuring good flavor and the like due to the component (b-1), and limiting the content of ethanol. However, the solubility or dispersibility of each component can be secured. The content of such ethanol is preferably 15 times or less, more preferably 10 times or less, further preferably 5 times or less, and 3 times or less with respect to the content of the component (b-1). May be. From the same viewpoint, the content of ethanol is preferably 8% by mass or less, more preferably 5% by mass or less, and further preferably 3% by mass or less in the liquid oral composition of the present invention. Or the liquid oral composition of the present invention preferably does not contain ethanol.
本発明の液体口腔用組成物において、各成分の溶解性又は分散性を確保しつつ、透明性又は半透明性の外観を付与する観点、及び泡吐出容器に充填した際に良好な吐出性を保持する観点から、研磨性粉体の含有を制限するのが好ましい。かかる研磨性粉体としては、例えば、軽質炭酸カルシウム、重質炭酸カルシウム、ゼオライト、吸油量が50〜150mL/100gの研磨性シリカ、第二リン酸カルシウム、第三リン酸カルシウム、不溶性メタリン酸ナトリウム、水酸化アルミニウム、リン酸マグネシウム、ピロリン酸カルシウム、及び炭酸マグネシウム等から選ばれる1種又は2種以上が挙げられる。
なお、吸油量とは、シリカが担持できる油量を示したものであり、測定方法はJIS K5101−13−2(2004年制定)に基づく方法により、吸収される煮あまに油の量により特定する。
In the liquid oral composition of the present invention, while ensuring the solubility or dispersibility of each component, from the viewpoint of imparting a transparent or translucent appearance, and good dischargeability when filled in a foam discharge container. From the viewpoint of holding, it is preferable to limit the content of the abrasive powder. Examples of the abrasive powder include light calcium carbonate, heavy calcium carbonate, zeolite, abrasive silica having an oil absorption of 50 to 150 mL / 100 g, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide. And one or more selected from magnesium phosphate, calcium pyrophosphate, magnesium carbonate, and the like.
The oil absorption amount indicates the amount of oil that can be supported by silica, and the measuring method is a method based on JIS K5101-13-2 (established in 2004), which is specified by the amount of boiled linseed oil absorbed. To do.
研磨性粉体の含有量は、製造直後から低温保存後に至るまで、各成分の溶解性又は分散性を確保する観点、及び透明性又は半透明性の外観を付与する観点から、本発明の液体口腔用組成物中に、好ましくは0.1質量%以下であり、より好ましくは0.05質量%以下であり、さらに好ましくは0.01質量%以下であり、或いは本発明の液体口腔用組成物は、研磨性粉体を含有しないのが好ましい。 The content of the abrasive powder is the liquid of the present invention from the viewpoint of ensuring the solubility or dispersibility of each component from immediately after production until after storage at low temperature, and from the viewpoint of imparting a transparent or translucent appearance. In the oral composition, preferably 0.1% by mass or less, more preferably 0.05% by mass or less, further preferably 0.01% by mass or less, or the liquid oral composition of the present invention. The article preferably does not contain abrasive powder.
本発明の液体口腔用組成物は、洗浄性能が高められるアルカリ性領域とする観点から、25℃におけるpHが8以上11以下であり、好ましくは8.5以上であり、より好ましくは9以上であり、好ましくは10.8以下であり、より好ましくは10.5以下である。
なお、本発明の液体口腔用組成物の25℃におけるpHを上記範囲に調整する上で、pH調整剤を用いてもよい。かかるpH調整剤としては、炭酸塩や重炭酸塩;水酸化カリウムや水酸化ナトリウム;クエン酸、リンゴ酸、乳酸、酒石酸、コハク酸等の有機酸又はこれらの塩から選ばれる1種又は2種以上が挙げられる。なかでも、炭酸塩、重炭酸塩が好ましく、炭酸ナトリウム、炭酸水素ナトリウム、セスキ炭酸ナトリウムが好ましい。この場合、pH調整剤の含有量は、液体口腔用組成物のpHを安定化させる観点から、本発明の液体口腔用組成物中に、好ましくは0.1〜2質量%であり、より好ましくは0.15〜1.5質量%であり、さらに好ましくは0.18〜1質量%であり、よりさらに好ましくは0.2〜0.8質量%である。
The liquid oral composition of the present invention has a pH at 25 ° C. of 8 or more and 11 or less, preferably 8.5 or more, and more preferably 9 or more, from the viewpoint of an alkaline region where the cleaning performance is enhanced. , Preferably 10.8 or less, more preferably 10.5 or less.
A pH adjuster may be used to adjust the pH of the liquid oral composition of the present invention at 25 ° C to the above range. As the pH adjuster, one or two kinds selected from carbonates and bicarbonates; potassium hydroxide and sodium hydroxide; organic acids such as citric acid, malic acid, lactic acid, tartaric acid and succinic acid, or salts thereof. The above is mentioned. Of these, carbonates and bicarbonates are preferable, and sodium carbonate, sodium hydrogen carbonate, and sodium sesquicarbonate are preferable. In this case, the content of the pH adjuster in the liquid oral composition of the present invention is preferably 0.1 to 2% by mass, and more preferably from the viewpoint of stabilizing the pH of the liquid oral composition. Is 0.15 to 1.5% by mass, more preferably 0.18 to 1% by mass, and even more preferably 0.2 to 0.8% by mass.
本発明の液体口腔用組成物は、本発明の効果を阻害しない範囲で、上記成分のほか、例えば、アルキル硫酸エステル塩等のアニオン界面活性剤;アルギン酸ナトリウム、カルボキシメチルセルロース又はその塩、ヒドロキシエチルセルロース、カラギーナン、キサンタンガム等の粘結剤;保存剤;顔料;色素等を適宜含有させることができる。なかでもアルキル硫酸エステル塩の含有量は、製造直後から低温保存後に至るまで良好な安定性を確保する観点から、本発明の液体口腔用組成物中に、好ましくは0.2質量%以下であり、より好ましくは0.1質量%以下であり、さらに好ましくは0.05質量%以下であり、よりさらに好ましくは0.01質量%以下であり、或いはアルキル硫酸エステル塩を含有しなくともよい。 The liquid oral composition of the present invention, in addition to the above components, within the range that does not impair the effects of the present invention, for example, anionic surfactants such as alkyl sulfate ester salts; sodium alginate, carboxymethyl cellulose or a salt thereof, hydroxyethyl cellulose, A binding agent such as carrageenan or xanthan gum; a preservative; a pigment; a dye or the like may be appropriately contained. Among them, the content of the alkyl sulfate ester salt is preferably 0.2% by mass or less in the liquid oral composition of the present invention from the viewpoint of ensuring good stability immediately after production until after storage at low temperature. , More preferably 0.1% by mass or less, further preferably 0.05% by mass or less, still more preferably 0.01% by mass or less, or the alkyl sulfate ester salt may not be contained.
本発明の液体口腔用組成物は、泡状で口腔内へ適用することにより、優れた使用感を実感しながら、口腔内の隅々まで上記液体口腔用組成物を行き渡らせる観点から、泡吐出容器に充填されてなるのが好ましい。かかる泡吐出容器は、吐出口を備えていればよく、ノンエアゾールタイプの容器であってもエアゾールタイプの容器であってもよい。本発明の液体口腔用組成物を使用する際には、泡吐出容器が備える吐出口から、内容物である上記液体口腔用組成物を口腔内へ直接吐出して、吐出口を経由した液体口腔用組成物を泡状で口腔内へ適用することができる。 The liquid oral composition of the present invention is applied to the oral cavity in the form of foam, and while realizing an excellent feeling of use, from the viewpoint of spreading the liquid oral composition to every corner of the oral cavity, foam ejection It is preferably filled in a container. The foam discharge container may be a non-aerosol type container or an aerosol type container as long as it has a discharge port. When using the liquid oral composition of the present invention, the liquid oral composition, which is the content, is directly ejected from the ejection opening of the foam ejection container into the oral cavity, and the liquid oral cavity is passed through the ejection opening. The composition can be applied in the oral cavity in the form of foam.
ノンエアゾールタイプの容器とは、圧縮ガス等の噴射剤が不要の常圧容器であり、かかる容器としては、例えば、スクイズタイプの容器とポンプタイプの容器が挙げられる。これらの容器は、内容物が吐出口を経由する際に良好に泡状の組成物を形成する観点、及び形成された泡が良好な保持性や均質性を有し、使用感等を高める等の観点から、いずれも容器本体から吐出口に至るまでの内容物の流路中に、メッシュや複数の小孔を設けた多孔質部材を介在させてなる容器であるのが好ましい。 The non-aerosol type container is a normal pressure container that does not require a propellant such as a compressed gas, and examples of such a container include a squeeze type container and a pump type container. These containers have a viewpoint of forming a foamy composition satisfactorily when the contents pass through the discharge port, and the formed foam has good retention and homogeneity, and enhances the usability, etc. From the viewpoint, it is preferable that each of the containers has a mesh or a porous member having a plurality of small holes interposed in the flow path of the content from the container body to the discharge port.
スクイズタイプの容器とは、変形可能な容器本体に位置する胴部をスクイズ変形させることにより、必要に応じて多孔質部材を経由させながら、ヘッドスペース内から圧送される空気と内容物を混合して泡を形成させ、かかる泡を吐出口から吐出させるものである。具体的には、例えば、特開平7−215352号公報、実開昭58−174272号公報、及び実開昭62−42787号公報に記載の容器等を用いることができる。 A squeeze-type container is a squeeze-deformation of the body located in the deformable container body to mix air with the air pressure-fed from within the headspace while passing through a porous member as necessary. To form bubbles, and the bubbles are discharged from the discharge port. Specifically, for example, the containers described in JP-A-7-215352, JP-A-58-174272, and JP-A-62-42787 can be used.
ポンプタイプの容器とは、吐出口を有する泡吐出器に備えられたポンプヘッドを押し込むことにより、必要に応じて多孔質部材を経由させながら、外部から流入する空気と内容物を混合して泡を形成させ、かかる泡を吐出口から吐出させるものである。通常、外部から空気を流入させるための空気シリンダーと、内容物の流路となる液シリンダーを備えるとともに、ポンプヘッドの押し込みにより圧送される空気と内容物とを混合させるための混合室を備える。具体的には、例えば、特開平7−315463号公報、特開平8−230961号公報、及び実開平3−7963号公報に記載の容器等を用いることができる。 A pump-type container is a foam head that is equipped with a foam dispenser that has a discharge port. Is formed and the bubbles are discharged from the discharge port. Usually, an air cylinder for inflowing air from the outside and a liquid cylinder serving as a flow path for the contents are provided, and a mixing chamber for mixing the air pressure-fed by pushing the pump head with the contents. Specifically, for example, the containers described in JP-A-7-315463, JP-A-8-230961, and JP-A-3-7963 can be used.
エアゾールタイプの容器とは、噴射剤として圧縮ガスを充填してなる容器であり、吐出口から内容物が吐出される際、バルブ機構を介してガスを取り込みながら泡が形成される。用いる圧縮ガスとしては、炭酸ガスを90質量%以上含有するガスであるのが好ましい。 An aerosol type container is a container filled with a compressed gas as a propellant, and when the content is discharged from a discharge port, bubbles are formed while taking in the gas through a valve mechanism. The compressed gas used is preferably a gas containing 90% by mass or more of carbon dioxide gas.
これら泡吐出容器のなかでも、使用性の観点、すなわち吐出口から内容物を口腔内へ直接吐出しやすい観点、及び利便性や携帯性にも優れる観点から、スクイズ容器が好ましく、容器本体から吐出口に至るまでの内容物の流路中に、#90〜#305のメッシュを備える容器がより好ましい。 Among these foam discharge containers, a squeeze container is preferable from the viewpoint of usability, that is, from the viewpoint of easily discharging the contents directly from the discharge port into the oral cavity, and also from the viewpoint of convenience and portability, and is discharged from the container body. A container having meshes of # 90 to # 305 in the flow path of the contents up to the outlet is more preferable.
本発明の液体口腔用組成物は、成分(B)を安定に溶解又は分散することができるため、透明又は半透明であって、着色されていてもよい。透明又は半透明であるとは、具体的には、液体口腔用組成物を光路長10mmのセルに充填した際における吸収波長550nmの光の透過率が80%以上であることを意味し、かかる透過率は、さらに90%以上であることが好ましい。なお、セルとしては、石英セルを用いる。 The liquid composition for oral cavity of the present invention can dissolve or disperse the component (B) in a stable manner, and thus may be transparent or translucent and may be colored. The term “transparent or translucent” specifically means that the transmittance of light having an absorption wavelength of 550 nm is 80% or more when a liquid oral composition is filled in a cell having an optical path length of 10 mm. The transmittance is preferably 90% or more. A quartz cell is used as the cell.
以下、本発明について、実施例に基づき具体的に説明する。なお、表中に特に示さない限り、各成分の含有量は質量%を示す。 Hereinafter, the present invention will be specifically described based on Examples. Unless otherwise specified in the table, the content of each component is% by mass.
[実施例1〜14、比較例1〜3]
表1に示す処方にしたがって、25℃におけるpHを10に調整した液体口腔用組成物を製造し、以下の方法にしたがって、各評価を行った。
結果を表1に示す。
また、本発明の液体口腔用組成物において、成分(b−1)の香料として用い得る具体的な香料を表2〜4に示す。なお、実施例1〜10、比較例1〜2では、表3に示す香料を用いた。
[Examples 1 to 14, Comparative Examples 1 to 3]
According to the formulation shown in Table 1, a liquid oral composition in which the pH at 25 ° C. was adjusted to 10 was produced, and each evaluation was performed according to the following methods.
The results are shown in Table 1.
Further, Tables 2 to 4 show specific fragrances that can be used as the fragrance of the component (b-1) in the liquid oral composition of the present invention. In addition, in Examples 1-10 and Comparative Examples 1-2, the fragrance | flavor shown in Table 3 was used.
《安定性の評価》
得られた各液体口腔用組成物をガラス瓶に充填し、充填直後と−5℃で一週間保存した後との双方について、ガラス瓶の外側から内容物の液体口腔用組成物を目視により観察し、以下の基準にしたがって評価した。
A:透明で均一であった
B:多少白濁していたものの、均一であった
C:白濁していたものの、析出物までは確認されなかった
D:析出物が確認された
《Stability evaluation》
Each of the obtained liquid oral compositions was filled in a glass bottle, and both immediately after filling and after storage for 1 week at -5 ° C, the liquid oral composition of the contents was visually observed from the outside of the glass bottle, Evaluation was made according to the following criteria.
A: Transparent and uniform B: Slightly cloudy but uniform C: Cloudy but no precipitate D: Precipitate was confirmed
表1の結果によれば、成分(b−1)と成分(A)との質量比((b−1)/(A))が1.7を超える比較例1、及び成分(b−2)と成分(A)との質量比((b−2)/(A))が0.2を超える比較例2〜3に比して、成分(B)として成分(b−1)のみを含有する実施例1〜7、及び成分(b−1)と成分(b−2)の双方を含有する実施例8〜14は、いずれも製造後に、香料、或いは香料と特定の油溶性薬効成分とを安定に含有し、透明性を良好に保持しており、実施例1〜2、4〜7、8〜11は、低温保存後においても、香料、或いは香料と特定の油溶性薬効成分とを安定に含有し、透明性を良好に保持できることがわかる。 According to the results of Table 1, Comparative Example 1 in which the mass ratio ((b-1) / (A)) of the component (b-1) and the component (A) exceeds 1.7, and the component (b-2) ) And the component (A) in a mass ratio ((b-2) / (A)) of more than 0.2, in comparison with Comparative Examples 2 to 3, only the component (b-1) is used as the component (B). Examples 1 to 7 containing, and Examples 8 to 14 containing both the component (b-1) and the component (b-2), after production, are fragrances, or fragrances and specific oil-soluble medicinal ingredients. Stable and contain transparency, and maintain good transparency, Examples 1-2, 4-7, 8-11, even after low temperature storage, fragrance, or fragrance and specific oil-soluble medicinal ingredients It can be seen that is contained stably, and the transparency can be satisfactorily maintained.
Claims (6)
(A)ヤシ油脂肪酸アミドアルキルベタイン、及びアルキルスルホベタインから選ばれる1種又は2種以上の両性界面活性剤、
(B)香料 0.2質量%以上1.5質量%以下(b−1)のみ、或いは
香料 0.2質量%以上1.5質量%以下(b−1)と、トリクロサン、イソプロピルメチルフェノール、β−グリチルレチン酸、及びアズレンから選ばれる1種又は2種以上の油溶性薬効成分(b−2)、
(C)水 55質量%以上98質量%以下
を含有し、ノニオン界面活性剤の含有量が1質量%以下であって成分(A)の含有量に対して1倍未満であり、成分(b−1)と成分(A)との質量比((b−1)/(A))が0.1以上1.7以下であり、成分(B)が成分(b−2)を含む場合における成分(b−2)と成分(A)との質量比((b−2)/(A))が0.005以上0.2以下であり、かつ
25℃におけるpHが8.5以上11以下である液体口腔用組成物。 The following components (A), (B), and (C):
(A) One or more amphoteric surfactants selected from coconut oil fatty acid amide alkyl betaine and alkyl sulfobetaine,
(B) Perfume 0.2 mass% or more and 1.5 mass% or less (b-1) only, or perfume 0.2 mass% or more and 1.5 mass% or less (b-1), triclosan, isopropylmethylphenol, β-glycyrrhetinic acid, and one or more oil-soluble medicinal components (b-2) selected from azulene,
(C) contained the following 55 wt% or more 98% by weight of water, the content of nonionic surfactant is less than 1 times the amount of the component (A) I der most 1 mass%, the component ( When the mass ratio ((b-1) / (A)) of b-1) and component (A) is 0.1 or more and 1.7 or less, and component (B) contains component (b-2). The mass ratio ((b-2) / (A)) between the component (b-2) and the component (A) in 0.005 to 0.2 and the pH at 25 ° C. is 8.5 to 11 A liquid oral composition which is:
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