JP7479254B2 - Dentifrice composition and method for inhibiting adsorption of isopropyl methylphenol to a container of a dentifrice composition - Google Patents

Description

The present invention relates to a dentifrice composition suitable for preventing or inhibiting periodontal disease, in which the adsorption of isopropyl methylphenol to a container is inhibited and isopropyl methylphenol is stabilized over time, and to a method for inhibiting the adsorption of isopropyl methylphenol to a container in a dentifrice composition.

The two major oral diseases, dental caries and periodontal disease, are believed to be caused by various bacteria in oral biofilms. Periodontal disease in particular is an infectious disease caused mainly by obligate anaerobic gram-negative bacilli such as Porphyromonas gingivalis, and the ability of a bactericide to penetrate into biofilms is an important criterion for selecting a bactericide.
Isopropyl methylphenol, a poorly water-soluble bactericide, has high oral biofilm penetration, and toothpastes containing isopropyl methylphenol are on the market.

However, because isopropylmethylphenol is a poorly water-soluble component, when it is mixed into an oral composition and filled into a container such as a tube, there is a problem that it is adsorbed by the resin, such as polyethylene, used as the container material, reducing stability, especially if the solubilization state is insufficient.

In response to this problem of container adsorption, Patent Documents 1 to 3 propose techniques for stably blending poorly water-soluble fungicides from the container surface, but these techniques have the problem that new issues arise in container manufacturing. For this reason, it is more effective to stabilize the poorly water-soluble fungicide from the perspective of the contents filled into the container.

As a technology for suppressing adsorption to the container from the viewpoint of the contents to be filled, Patent Documents 4 to 7 propose a technology for improving the residual rate of a poorly water-soluble bactericide over time by blending an appropriate surfactant or a salt such as sodium sulfate together with the poorly water-soluble bactericide in a dentifrice composition. Patent Documents 4 and 5 disclose that the residual rate of isopropyl methylphenol is improved by polyoxyethylene alkyl ether or polyoxyethylene hydrogenated castor oil and a cationic surfactant, and Patent Document 6 discloses that the bactericidal power of isopropyl methylphenol after storage is improved by polyoxyethylene alkyl ether and sodium sulfate.

Japanese Patent Application Laid-Open No. 2-288820 Japanese Patent Application Laid-Open No. 6-92830 Japanese Patent Application Laid-Open No. 6-279248 JP 2003-292426 A JP 2005-179266 A JP 2008-115115 A JP 2012-136446 A

However, there is a problem that the greater the amount of nonionic surfactant or salt used, the lower the bactericidal activity of isopropyl methylphenol and the lower the stability of the formulation. For this reason, there is a need for the development of a new technology that can suppress the adsorption of isopropyl methylphenol to the container and improve stability.

The present invention has been made in consideration of the above circumstances, and aims to provide a dentifrice composition in which adsorption of isopropyl methylphenol to a container is suppressed and in which isopropyl methylphenol is stabilized over time, and a method for suppressing adsorption of isopropyl methylphenol to a container in a dentifrice composition.

As a result of extensive investigations aimed at solving the above problems, the inventors have discovered that by blending (A) isopropyl methyl phenol with (B) an anionic surfactant and (C) a nonionic surfactant together, and filling a dentifrice composition in a container with an innermost layer made of polyethylene, and blending (D) a fluorine compound at 1,100 to 3,000 ppm in terms of fluorine, the adsorption of isopropyl methyl phenol to the container is suppressed, isopropyl methyl phenol is stabilized over time, sufficient and appropriate foaming is achieved, and the appearance stability of the formulation can be ensured, which has led to the creation of the present invention.

Fluorine is generally added to dentifrice compositions, but the concentration is generally about 1,000 ppm or less. If a fluorine compound is added at a fluorine concentration of less than 1,100 ppm, it will be impossible to suppress adsorption of isopropyl methylphenol to the container in a dentifrice composition in which component (A) is combined with components (B) and (C) and packed in the above-mentioned container. However, when a fluorine compound of component (D) is used at a high concentration of 1,100 ppm or more in terms of fluorine, unexpectedly, the fluorine compound of component (D) acts as an adsorption inhibitor to suppress adsorption of isopropyl methylphenol to the container, thereby providing the above-mentioned special functional effect.
In this case, even if the dentifrice composition contains (A) isopropyl methylphenol, (B) anionic surfactant to ensure foaming, and (C) nonionic surfactant to solubilize isopropyl methylphenol, the problem of isopropyl methylphenol adsorbing to the container and decreasing the remaining rate over time cannot be solved, and an increase in the amount of nonionic surfactant leads to a decrease in the stability of the preparation and further to a decrease in the bactericidal power of isopropyl methylphenol, and an increase in the amount of anionic surfactant leads to a loss of solubilization balance, which leads to an increase in container adsorption. Therefore, the present inventors have further investigated in order to ensure sufficient and appropriate foaming without decreasing the stability of the preparation and to suppress the adsorption of isopropyl methylphenol to the container, and as a result, in the combination of (A), (B), and (C), the fluorine compound of (D) component acts specifically as an adsorption inhibitor as described above, thereby providing stability in which isopropyl methylphenol remains at a high rate over time, and also providing sufficient and appropriate foaming and external appearance stability of the preparation that can suppress liquid separation even when stored at 60°C for one month. Furthermore, the taste was also maintained at a good level. Therefore, according to the dentifrice composition of the present invention, it is possible to effectively use isopropyl methylphenol and fully exhibit its oral biofilm penetrating bactericidal activity, and the composition can be suitably used for preventing or suppressing periodontal disease.

Based on Patent Documents 4 to 7, which show that the adsorption of poorly water-soluble disinfectants to containers is suppressed and the residual rate is improved by using surfactants and salts such as sodium sulfate, it is not possible to predict that isopropylmethylphenol would be stabilized by fluorine compounds.

Therefore, the present invention provides the following dentifrice composition and method for inhibiting adsorption of isopropylmethylphenol to a container of a dentifrice composition.
Claim 1:
(A) isopropyl methylphenol,
(B) an anionic surfactant,
(C) A dentifrice composition containing a nonionic surfactant and filled in a container having an innermost layer made of polyethylene,
(D) Fluorine compounds: 1,100 to 3,000 ppm as fluorine
A dentifrice composition comprising:
Claim 2:
The dentifrice composition according to claim 1, wherein the nonionic surfactant (C) is polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 100 and/or polyoxyethylene alkyl ether having an average added mole number of ethylene oxide of 5 to 40 and an alkyl group having 10 to 18 carbon atoms.
Claim 3:
3. The dentifrice composition according to claim 1 or 2, wherein the anionic surfactant (B) is sodium lauryl sulfate.
Claim 4:
4. A dentifrice composition according to claim 1, 2 or 3, containing 0.01 to 0.3 mass% of component (A), 0.6 to 2.5 mass% of component (B), and 0.5 to 3 mass% of component (C).
Claim 5:
5. The dentifrice composition according to claim 1, wherein the mass ratio of (B)/(C) is 0.2 to 3.
Claim 6:
The dentifrice composition according to any one of claims 1 to 5, further comprising an abrasive.
Claim 7:
(A) isopropyl methylphenol,
(B) an anionic surfactant,
(C) A dentifrice composition containing a nonionic surfactant and filled in a container having an innermost layer made of polyethylene,
(D) Fluorine compounds: 1,100 to 3,000 ppm as fluorine
A method for inhibiting adsorption of isopropyl methylphenol to a container of a dentifrice composition, comprising:
Claim 8:
8. A method for inhibiting adsorption of isopropylmethylphenol to a container of a dentifrice composition according to claim 7, wherein the mass ratio of (B)/(C) is 0.2 to 3.

According to the present invention, it is possible to provide a dentifrice composition in which isopropyl methylphenol is inhibited from being adsorbed to a container, isopropyl methylphenol is stabilized over time, and the composition foams sufficiently and appropriately, and has good stability in the appearance of the formulation. This dentifrice composition is capable of effectively acting on isopropyl methylphenol to fully express its oral biofilm penetrating bactericidal power, and can be suitably used for preventing or suppressing periodontal disease.

The present invention will be described in further detail below. The dentifrice composition of the present invention contains (A) isopropylmethylphenol, (B) anionic surfactant, (C) nonionic surfactant, and (D) a fluorine compound.

In the present invention, the content of (A) isopropyl methylphenol is preferably 0.01 to 0.3% (mass%, the same applies below) of the entire composition, and more preferably 0.02 to 0.1%. The greater the amount, the greater the bactericidal effect, and if it is 0.01% or more, a sufficient bactericidal effect is exhibited and the stability of isopropyl methylphenol can be sufficiently ensured. A content of 0.3% or less is preferable to ensure good taste.

(B) Anionic surfactants are not particularly limited, but examples include alkyl sulfates such as sodium lauryl sulfate, acyl sarcosinates such as sodium lauroyl sarcosine, acyltaurates such as sodium lauroyl methyl taurate, N-acyl amino acid salts such as sodium lauroyl glutamate, N-acylsulfonates such as sodium α-olefin sulfonate, sulfates of glycerin fatty acid esters, etc. Among these, in terms of foaming and taste, alkyl sulfates, acyl sarcosinates, acyltaurates, N-acyl amino acid salts, particularly alkyl sulfates, and especially sodium lauryl sulfate are preferred.

The content of (B) anionic surfactant is 0.6% or more of the total composition, preferably 0.6 to 2.5%, and more preferably 0.8 to 1.8%. A content of 0.6% or more ensures sufficient foaming. A content of 2.5% or less is suitable for ensuring sufficient stability of isopropyl methylphenol and stability of the appearance of the formulation.

(C) Nonionic surfactants are not particularly limited, but examples include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, sucrose fatty acid esters, alkyl glycosides, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene ethers of glycerin esters, fatty acid alkylol amides, and glycerin fatty acid esters. Among these, in terms of the stability and taste of isopropylmethylphenol, polyoxyethylene hydrogenated castor oil with an average number of added moles of ethylene oxide of 20 to 100 moles, polyoxyethylene alkyl ether with an alkyl group having 10 to 18 carbon atoms and an average number of added moles of ethylene oxide of 5 to 40 moles, sucrose fatty acid ester with a fatty acid having 10 to 22 carbon atoms and a ratio of monoester esterified with one fatty acid of 50% or more, and alkyl glycoside with an alkyl group having 8 to 16 carbon atoms are preferred, and in particular, polyoxyethylene hydrogenated castor oil with an average number of added moles of ethylene oxide of 20 to 100 moles, polyoxyethylene alkyl ether with an alkyl group having 10 to 18 carbon atoms and an average number of added moles of ethylene oxide of 5 to 40 moles, and polyoxyethylene hydrogenated castor oil with an average number of added moles of ethylene oxide of 20 to 100 moles are preferred.

The content of (C) the nonionic surfactant is preferably 0.5 to 3% of the total composition, more preferably 1.0 to 2.5%. If it is 0.5% or more, the stability of isopropyl methylphenol can be sufficiently ensured. If it is 3% or less, it is suitable for ensuring sufficient stability of the appearance of the formulation.

Furthermore, (B)/(C), which indicates the blending ratio of (B) the anionic surfactant and (C) the nonionic surfactant, is preferably 0.2 to 3, more preferably 0.4 to 1.5, as a mass ratio. When (B)/(C) is within the above range, it is more suitable for improving the stability of isopropyl methylphenol, and the appearance stability and foaming of the formulation can be sufficiently ensured. If it is less than 0.2, the foaming and taste may be inferior, and if it exceeds 3, the stability of isopropyl methylphenol may be inferior.

In the present invention, in the combination of components (A), (B) and (C), the fluorine compound (D) acts as a stabilizer for isopropylmethylphenol.
(D) Examples of the fluorine compound include sodium fluoride, sodium monofluorophosphate, and strontium fluoride, with sodium fluoride and sodium monofluorophosphate being particularly preferred.

The content of the fluorine compound (D) is 1,100 to 3,000 ppm, preferably 1,200 to 3,000 ppm, more preferably 1,400 to 2,500 ppm, in terms of fluorine, relative to the entire composition. If the content is less than 1,100 ppm, the stability of isopropyl methyl phenol is poor and it cannot be stabilized. As the fluorine concentration increases, the stability of isopropyl methyl phenol improves, but if it exceeds 3,000 ppm, the appearance stability of the formulation deteriorates.
In addition, within the above-mentioned range of the fluorine content, specifically, the content of sodium fluoride is preferably 0.25 to 0.66% of the entire composition, and the content of sodium monofluorophosphate is preferably 0.84 to 2.27% of the entire composition.

The dentifrice composition of the present invention is preferably prepared as a dentifrice such as toothpaste or liquid dentifrice, particularly toothpaste, and in addition to the above-mentioned components, other known components may be blended depending on the dosage form within the range that does not impair the effects of the present invention. Specifically, abrasives, thickening agents, binders, sweeteners such as sodium saccharin, preservatives such as paraoxybenzoic acid esters or salts thereof, colorants such as titanium oxide, flavors, active ingredients, etc. may be blended.
It is not necessary to add surfactants other than anionic surfactants and nonionic surfactants, but cationic surfactants and amphoteric surfactants may be added within the range that does not impair the effects of the present invention.

Examples of the abrasive include silica-based abrasives such as silicic acid anhydride and silicic acid hydrate, calcium phosphate-based abrasives such as calcium hydrogen phosphate, calcium carbonate, zeolite, calcium pyrophosphate, aluminum hydroxide, alumina, hydroxyapatite, magnesium carbonate, magnesium tertiary phosphate, zirconium silicate, crystalline cellulose, etc. In particular, silica-based abrasives and calcium phosphate-based abrasives are preferred from the viewpoint of usability, and among them, silicic acid anhydride, which is a silica-based abrasive, is more suitable from the viewpoint of fully exerting the effect of the fluorine compound.
Furthermore, when a silicic anhydride having a BET specific surface area of preferably 50 to 400 ^m2 /g, more preferably 80 to 250 ^m2 /g is used, it is possible to obtain a sufficient cleaning effect while reducing abrasiveness. The BET specific surface area is a value measured based on the Japanese Industrial Standard (JIS 8830).
The content of the abrasive is preferably 5 to 40%, more preferably 5 to 20%, of the entire composition.

Thickening agents include sugar alcohols such as sorbitol, propylene glycol, etc. The amount of thickening agent is usually 5 to 50%, and particularly 20 to 45%.

Examples of binders include organic binders such as sodium polyacrylate, alginic acid derivatives such as sodium alginate, cellulose derivatives such as sodium carboxymethylcellulose, and gums such as xanthan gum, as well as inorganic binders. The amount of binder used is usually 0.1 to 5%.

Fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, and sweet ginger oil. Natural fragrances such as yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, and processed fragrances (front distillation, back distillation, liquid-liquid extraction, essences, powdered fragrances, etc.) of these natural fragrances, as well as menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthoxypropane-1,2-diol, methyl salicylate, ethyl ... [0043] The flavoring materials may be used in combination with known flavoring materials used in oral compositions, such as single flavorings such as tallow, menthyl acetate, N-substituted-paramenthan-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioacetate, as well as blended flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor, but are not limited to the flavors described in the examples.
The above-mentioned flavor materials are preferably used in an amount of 0.000001 to 1% in the formulation, and flavorings using the above-mentioned flavor materials are preferably used in an amount of 0.1 to 2% in the formulation.

Active ingredients include isopropylmethylphenol, fluorine compounds, and other known oral medicinal ingredients, specifically cationic bactericides, anti-inflammatory agents, enzymes, plant extracts, anti-tartar agents, and anti-plaque agents, which can be blended in effective amounts within a range that does not interfere with the effects of the present invention.

The dentifrice composition of the present invention is suitably packed in a tube container whose innermost layer is made of polyethylene.
Examples of such containers include those having a laminate layer structure consisting of, from the outer layer, low-density polyethylene/ethylene-acrylic acid copolymer resin/aluminum/ethylene-acrylic acid copolymer resin/linear low-density polyethylene (innermost layer), low-density polyethylene/ethylene-vinyl alcohol copolymer/low-density polyethylene/ethylene-vinyl alcohol copolymer/linear low-density polyethylene (innermost layer), and low-density polyethylene/polyethylene terephthalate/low-density polyethylene/glass-deposited polyethylene terephthalate/ethylene-methacrylic acid copolymer resin/linear low-density polyethylene (innermost layer). As long as the innermost layer is polyethylene, the other layer configurations may be any, and it is particularly preferable that the innermost layer is linear low-density polyethylene.

Linear low-density polyethylene is also called linear low-density polyethylene, and is produced by copolymerizing an α-olefin (e.g., butene-1, hexene-1, 4-methylpentene, octene-1) with a linear polymer in the high-density polyethylene production process to introduce short chain branches and reduce the density. Linear low-density polyethylene for extrusion coating generally has a density of 0.915 to 0.938 g/ ^cm3 .
The thickness of the innermost polyethylene layer is not particularly limited, but is usually about 30 to 100 μm, and the total thickness of the laminate layer is usually 200 to 450 μm.
In the above-mentioned tube container, the ingredients in the contents are easily adsorbed, particularly to the contents discharge port and the shoulder connecting the body, especially to the shoulder. However, in the present invention, even if the innermost layer of each of the above-mentioned parts is polyethylene, adsorption of isopropyl methylphenol is suppressed, and the stability is excellent.

Such tube containers with an innermost layer made of polyethylene can be commercially available. For example, toothpaste tubes can be obtained from container and packaging manufacturers such as Dai Nippon Printing Co., Ltd. and Toppan Printing Co., Ltd.

The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following, % means mass % unless otherwise specified. Examples 5 and 10 are reference examples.

[Examples and Comparative Examples]
Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method and filled into tube containers as described below. These test dentifrice compositions were evaluated by the following methods. The results are shown in Tables 1 to 3.

Preparation of test dentifrice compositions 60 g of each dentifrice composition was packed into a laminate tube having a diameter of 26 mm and an innermost layer made of linear low-density polyethylene (LDPE55/PET12/LDPE20/white LDPE60/EMAA20/AL10/EMAA30/LDPE20/LLDPE30, thickness 257 μm (manufactured by Dai Nippon Printing Co., Ltd.)).
The abbreviations and names of the layer structures of the laminate tubes used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: White low-density polyethylene LDPE: White low-density polyethylene LLDPE: Linear low-density polyethylene AL: Aluminum EAA: Ethylene-acrylic acid copolymer resin PET: Polyethylene terephthalate EMAA: Ethylene-methacrylic acid copolymer resin SiOx-PET: Glass-deposited polyethylene terephthalate

(1) Method for evaluating the stability of isopropyl methylphenol The amount of isopropyl methylphenol in the dentifrice composition after storage at 60° C. for one month was measured using HPLC under the following test conditions. The remaining rate was calculated when the amount of isopropyl methylphenol immediately after the preparation of each sample was taken as 100%, and the stability of isopropyl methylphenol was evaluated according to the following evaluation criteria, and shown in the table as IPMP stability.
Test condition;
Detector: ultraviolet spectrophotometer (measurement wavelength: 285 nm)
Column: YMC-Pack ODS-A A-303 (4.6 mmφ×250 mm)
Column temperature: 45°C
Mobile phase: Acetonitrile/water/acetic acid mixture (60:40:1)
Used equipment;
Pump: JASCO Corporation, PU-980
Sample introduction section: JASCO Corporation, AS-950
Detector: JASCO Corporation, UV-970
Column thermostat: JASCO Corporation, CO-960
Flow rate: 1 mL/min
Judgment criteria;
◎: 97% or more and 100% or less ○: 94% or more and less than 97% △: 90% or more and less than 94% ×: Less than 90%

(2) Evaluation method for appearance stability of preparations Dentifrice compositions stored at 60° C. for one month were ejected onto a piece of straw paper to a depth of about 15 cm. Liquid separation stability was evaluated based on the length of water that had soaked into the back of the straw paper, according to the following criteria.
Criteria: ◎: Less than 0.2 cm ○: 0.2 cm or more but less than 0.5 cm ×: 0.5 cm or more

(3) Method for evaluating foaming The dentifrice composition was applied to a toothbrush and the foaming generated when the oral cavity was cleaned was evaluated by five subjects according to the following rating scale. The scores of the five subjects were averaged and the foaming was evaluated according to the following judging scale.
Scoring criteria:
5 points: good foaming; 4 points: some foaming; 3 points: neither good nor bad; 2 points: some poor foaming; 1 point: poor foaming. Evaluation criteria:
◎: Average score of 4.0 points or more ○: Average score of 3.0 points or more and less than 4.0 points △: Average score of 2.0 points or more and less than 3.0 points ×: Average score of less than 2.0 points

As is clear from the results in Tables 1 to 3, when component (A) is mixed with components (B) and (C), as shown in the comparative examples, IPMP stability is poor, and even if component (D) is added, the IPMP stability is poor if the amount of component (D) or the (B)/(C) ratio is inappropriate. However, the dentifrice composition of the present invention (Example) in which component (A), (B), and (C) are combined with component (D) in an appropriate amount and within an appropriate (B)/(C) ratio range, exhibited excellent IPMP stability, formulation appearance stability, and foaming. In addition, the taste after brushing was also good.

Claims (11)

(A) isopropyl methylphenol,
(B) an anionic surfactant,
(C) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 100 is blended, (B)/(C) is a mass ratio of 0.4 to 1.3, and the dentifrice composition is filled in a container having an innermost layer made of linear low-density polyethylene,
(D) Fluorine compounds: 1,400 to 2,500 ppm as fluorine
A dentifrice composition comprising: The dentifrice composition according to claim 1, which contains component (D) as an agent for inhibiting the adsorption of component (A) to the innermost layer of the container. 3. The dentifrice composition according to claim 1 or 2 , containing 0.01 to 0.3 mass% of component (A), 0.6 to 2.5 mass% of component (B), and 0.5 to 3 mass% of component (C). The dentifrice composition according to any one of claims 1 to 3, wherein the mass ratio of (B)/(C) is 0.5 to 1.2. The dentifrice composition according to any one of claims 1 to 4 further contains 5 to 40% by mass of an abrasive. The dentifrice composition according to any one of claims 1 to 5, which is a toothpaste. The dentifrice composition according to any one of claims 1 to 6, which is used to inhibit the adsorption of isopropyl methylphenol to the innermost layer of a container. (A) isopropyl methylphenol,
(B) an anionic surfactant,
(C) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 100 is blended, (B)/(C) is a mass ratio of 0.4 to 1.3, and the dentifrice composition is filled in a container having an innermost layer made of linear low-density polyethylene,
(D) Fluorine compounds: 1,400 to 2,500 ppm as fluorine
A method for inhibiting adsorption of isopropyl methylphenol to a container of a dentifrice composition, comprising: A method for inhibiting adsorption of isopropylmethylphenol to a container in a dentifrice composition according to claim 8, wherein the mass ratio of (B)/(C) is 0.5 to 1.2. The method for suppressing adsorption of isopropylmethylphenol to the innermost layer of a container of a dentifrice composition according to claim 8 or 9, which further comprises 5 to 40% by mass of an abrasive. A method for inhibiting adsorption of isopropylmethylphenol to the innermost layer of a container of a dentifrice composition according to any one of claims 8 to 10, wherein the dentifrice composition is a toothpaste.