JP6985786B2 - Method for suppressing adsorption of isopropylmethylphenol to a dentifrice composition and a container in the dentifrice composition - Google Patents

Description

INDUSTRIAL APPLICABILITY According to the present invention, adsorption of isopropylmethylphenol to a container is suppressed, and isopropylmethylphenol is stabilized over time, which is suitable for the prevention or suppression of periodontal disease. The present invention relates to a method for suppressing the adsorption of phenol.

The causes of the two major oral diseases, caries and periodontal disease, are thought to be due to various bacteria in the oral biofilm. In particular, periodontal disease is an infectious disease caused by bacteria such as Porphyromonas gingivalis and obligate anaerobic gram-negative bacilli, and its ability to penetrate biofilms is important as a criterion for selecting a bactericidal agent.
Since isopropylmethylphenol, which is a poorly water-soluble fungicide, has high permeability to oral biofilms, dentifrices using isopropylmethylphenol have been put on the market.

However, since isopropylmethylphenol is a poorly water-soluble component, when it is mixed with an oral composition and filled in a container such as a tube, a resin such as polyethylene used as a container material is used especially when the solubilized state is insufficient. There was a problem that it was adsorbed on polyethylene and its stability was lowered.

To solve such a problem of container adsorption, Patent Documents 1 to 3 propose techniques for stably blending a poorly water-soluble bactericidal agent from the surface of the container, but these techniques are new to those involved in container manufacturing. There is a problem that a problem arises, and therefore, it is effective to stabilize the poorly water-soluble bactericide in terms of the contents to be filled in the container.

As a technique for suppressing adsorption to a container from the aspect of the contents to be filled, Patent Documents 4 to 7 include an appropriate surfactant and a salt such as sodium sulfate in the dentifrice composition together with a poorly water-soluble disinfectant. By doing so, a technique for improving the residual rate of the poorly water-soluble fungicide over time has been proposed. In Patent Documents 4 and 5, the residual ratio of isopropylmethylphenol is improved by polyoxyethylene alkyl ether, or polyoxyethylene hydrogenated castor oil and a cationic surfactant, and in Patent Document 6, polyoxyethylene alkyl ether and sodium sulfate are used. Discloses that the bactericidal activity of isopropylmethylphenol after storage is improved.

Japanese Unexamined Patent Publication No. 2-288820 Japanese Unexamined Patent Publication No. 6-92830 Japanese Unexamined Patent Publication No. 6-279248 Japanese Unexamined Patent Publication No. 2003-292426 Japanese Unexamined Patent Publication No. 2005-179266 Japanese Unexamined Patent Publication No. 2008-115115 Japanese Unexamined Patent Publication No. 2012-136446

However, as the amount of the nonionic surfactant or salt is increased, there is a problem that the bactericidal activity of isopropylmethylphenol is lowered and the formulation stability is lowered. Therefore, the adsorption of isopropylmethylphenol to the container is suppressed. It was desired to develop a new technology to improve the stability.

The present invention has been made in view of the above circumstances. Adsorption of isopropylmethylphenol to a container in a toothpaste composition and a toothpaste composition in which adsorption of isopropylmethylphenol to a container is suppressed and isopropylmethylphenol is stabilized over time The purpose is to provide a suppression method.

As a result of repeated studies to solve the above problems, the present inventors have blended (B) an anionic surfactant and (C) a nonionic surfactant together with (A) isopropylmethylphenol, and the innermost layer is polyethylene. By blending 1,100 to 3,000 ppm of the (D) fluorine compound as fluorine in the toothpaste composition filled in the container made of isopropylmethylphenol, the adsorption of isopropylmethylphenol to the container is suppressed, and isopropylmethylphenol is produced over time. The present invention has been made by finding that it can be stabilized, and that sufficient and appropriate foaming and appearance stability of the pharmaceutical product can be ensured.

Generally, fluorine is added to the toothpaste composition, but the concentration is generally about 1,000 ppm or less, and if the fluorine compound is added at such a fluorine concentration of less than 1,100 ppm, ( In the toothpaste composition in which the components (B) and (C) are combined together with the component A) and filled in the above container, the fluorine compound of the component (D) is used as fluorine 1, although the adsorption of isopropylmethylphenol in the container cannot be suppressed. When used at a high concentration of 100 ppm or more, the fluorine compound of the component (D) acts as an adsorption inhibitor to suppress the adsorption of isopropylmethylphenol in a container, which gives the above-mentioned special action and effect.
In this case, (A) isopropylmethylphenol is blended in the toothpaste composition, (B) an anionic surfactant is blended to ensure foaming, and (C) a nonionic interface is blended to solubilize the isopropylmethylphenol. Even if an activator is added, the problem that isopropylmethylphenol is adsorbed on the container and the residual rate decreases over time cannot be solved, and increasing the amount of nonionic surfactant reduces the formulation stability and further, isopropylmethylphenol. In addition, the increase in the amount of anionic surfactant caused the solubilization balance to be disturbed, resulting in an increase in container adsorption. Therefore, the present inventors have further studied in order to secure sufficient and appropriate foaming without deteriorating the stability of the pharmaceutical product and suppress the adsorption of isopropylmethylphenol in a container, and as a result, (A) and (B). ), In the combination of the components (C), the fluorine compound of the component (D) acts specifically as an adsorption inhibitor as described above, thereby giving the stability that isopropylmethylphenol remains at a high rate over time. In addition, it was possible to impart sufficient and moderate foaming and appearance stability of the preparation capable of suppressing liquid separation even when stored at 60 ° C. for 1 month. Furthermore, the taste could be kept good. Therefore, according to the toothpaste composition of the present invention, isopropylmethylphenol can be effectively allowed to act and its oral biofilm penetrating bactericidal activity can be sufficiently expressed, and is suitably used for prevention or suppression of periodontal disease. can do.

From Patent Documents 4 to 7 in which the adsorption of the poorly water-soluble bactericide to the container is suppressed by a surfactant, a salt such as sodium sulfate, and the residual ratio is improved, it cannot be predicted that the isopropylmethylphenol will be stabilized by the fluorine compound. ..

Therefore, the present invention provides a method for suppressing adsorption of isopropylmethylphenol to the innermost layer of a container in the following dentifrice compositions and dentifrice compositions.
[1]
(A) 0.02 to 0.3% by mass of isopropylmethylphenol,
(B) Sodium lauryl sulfate in an amount of 0.6 to 1.8% by mass,
(C) 1.0 to 2.5% by mass of polyoxyethylene hydrogenated castor oil having an average addition mole number of 20 to 100 of ethylene oxide.
(B) / (C) as a mass ratio of 0.4 to 1.3, and (D) a fluorine compound was added to a toothpaste composition filled in a container having an innermost layer made of linear low-density polyethylene. A toothpaste composition comprising 1,400 to 2,500 ppm of fluorine as fluorine.
[2]
The toothpaste composition according to [1], which contains the component (D) as an inhibitor for the adsorption of the component (A) to the innermost layer of the container.
[ 3 ]
The toothpaste composition according to [1] or [2], wherein (B) / (C) has a mass ratio of 0.5 to 1.2.
[ 4 ]
The dentifrice composition according to any one of [1] to [3], which further contains 5 to 40% by mass of an abrasive.
[ 5 ]
Dentifrice composition according to any one of which is for inhibiting adsorption of isopropyl methylphenol to the innermost layer of the container in dentifrices compositions [1] to [4].
[ 6 ]
The toothpaste composition according to any one of [1] to [ 5], which is a toothpaste.
[ 7 ]
(A) 0.02 to 0.3% by mass of isopropylmethylphenol,
(B) Sodium lauryl sulfate in an amount of 0.6 to 1.8% by mass,
(C) 1.0 to 2.5% by mass of polyoxyethylene hydrogenated castor oil having an average addition mole number of 20 to 100 of ethylene oxide.
(B) / (C) as a mass ratio of 0.4 to 1.3, and the fluorine compound (D) was added to the toothpaste composition filled in a container whose innermost layer was made of linear low-density polyethylene. A method for suppressing adsorption of isopropylmethylphenol to the innermost layer of a container in the toothpaste composition, which comprises blending 1,400 to 2,500 ppm of fluorine.
[ 8 ]
The method for suppressing the adsorption of isopropylmethylphenol on the innermost layer of a container in the toothpaste composition according to [7 ], wherein (B) / (C) has a mass ratio of 0.5 to 1.2.
[ 9 ]
Further, a method for suppressing adsorption of isopropylmethylphenol to the innermost layer of a container in the dentifrice composition according to [7 ] or [ 8 ], which is a dentifrice composition containing 5 to 40% by mass of an abrasive.
[ 10 ]
The method for suppressing the adsorption of isopropylmethylphenol on the innermost layer of a container in the toothpaste composition according to any one of [7 ] to [ 9 ], wherein the toothpaste is a toothpaste.

According to the present invention, it is possible to provide a dentifrice composition in which isopropylmethylphenol is suppressed from being adsorbed in a container, isopropylmethylphenol is stabilized over time, sufficient and appropriate foaming is performed, and the appearance stability of the pharmaceutical product is good. The composition can effectively exert isopropylmethylphenol to sufficiently express its oral biofilm penetrating bactericidal activity, and can be suitably used for prevention or suppression of periodontal disease.

Hereinafter, the present invention will be described in more detail. The toothpaste composition of the present invention contains (A) isopropylmethylphenol, (B) anionic surfactant, (C) nonionic surfactant, and (D) a fluorine compound.

In the present invention, the content of (A) isopropylmethylphenol is preferably 0.01 to 0.3% (mass%, hereinafter the same) of the entire composition, and more preferably 0.02 to 0.1%. Is. The larger the amount, the higher the bactericidal effect, and when it is 0.01% or more, a sufficient bactericidal effect is exhibited, and the stability of isopropylmethylphenol can be sufficiently ensured. It is suitable that it is 0.3% or less in order to secure a good taste.

The (B) anionic surfactant is not particularly limited, and is, for example, an alkyl sulfate such as sodium lauryl sulfate, an acyl sulcosate such as sodium lauroyl sulcocin, an acyl taurine salt such as sodium lauroylmethyl taurine, and lauroyl glutamate. Examples thereof include N-acylamino acid salts such as sodium, N-acylsulfonates such as α-olefin sulfonic acid sodium, and sulfates of glycerin fatty acid ester. Of these, alkyl sulfates, acylsulfosates, acyltaurine salts, N-acylamino acid salts, particularly alkyl sulfates, especially sodium lauryl sulfate are preferable in terms of foaming and taste.

The content of the (B) anionic surfactant is preferably 0.6% or more, particularly preferably 0.6 to 2.5%, and more preferably 0.8 to 1.8% of the entire composition. When it is 0.6% or more, sufficient foaming can be secured. It is suitable that the content is 2.5% or less in order to sufficiently secure the stability of the isopropylmethylphenol and the appearance stability of the pharmaceutical product.

(C) The nonionic surfactant is not particularly limited, and is, for example, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, sucrose fatty acid ester, alkyl glycoside, polyoxyethylene-polyoxypropylene block co-weight. Examples thereof include polyoxyethylene ether of glycerin ester, fatty acid alkylolamide, and glycerin fatty acid ester. Among these, in terms of stability and taste of isopropylmethylphenol, polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 20 to 100 mol, and having an alkyl group having 10 to 18 carbon atoms and ethylene. Polyoxyethylene alkyl ether having an average addition molar number of oxides of 5 to 40 mols, sucrose fatty acid having a fatty acid having 10 to 22 carbon atoms and having a monoester having one fatty acid esterified in an proportion of 50% or more. Esters and alkyl glycosides having an alkyl group having 8 to 16 carbon atoms are preferable, and in particular, polyoxyethylene hydrogenated castor oil having an average addition molar number of 20 to 100 mol of ethylene oxide and having an alkyl group having 10 to 18 carbon atoms are preferable. Polyoxyethylene alkyl ethers having an average added mole number of ethylene oxide of 5 to 40 mol, particularly polyoxyethylene hydrogenated castor oil having an average added mole number of 20 to 100 mol of ethylene oxide are preferable.

The content of the (C) nonionic surfactant is preferably 0.5 to 3%, more preferably 1.0 to 2.5% of the total composition. When it is 0.5% or more, the stability of isopropylmethylphenol can be sufficiently ensured. It is suitable that the content is 3% or less in order to sufficiently secure the appearance stability of the pharmaceutical product.

Further, (B) / (C) indicating the blending ratio of the (B) anionic surfactant and the (C) nonionic surfactant is preferably 0.2 to 3 as a mass ratio, which is more preferable. Is 0.4 to 1.5. When (B) / (C) is within the above range, it is more suitable for improving the stability of the isopropylmethylphenol, and the appearance stability and foaming of the pharmaceutical product can be sufficiently ensured. If it is less than 0.2, it may foam and the taste may be inferior, and if it exceeds 3, the stability of isopropylmethylphenol may be inferior.

In the present invention, in the combination of the components (A), (B) and (C), the fluorine compound (D) acts as a stabilizer for isopropylmethylphenol.
Examples of the fluorine compound (D) include sodium fluoride, sodium monofluorophosphate, strontium fluoride and the like, and sodium fluoride and sodium monofluorophosphate are particularly preferable.

The content of the fluorine compound (D) is 1,100 to 3,000 ppm as fluorine, preferably 1,200 to 3,000 ppm, and more preferably 1,400 to 2,500 ppm with respect to the entire composition. be. If it is less than 1,100 ppm, the stability of isopropylmethylphenol is inferior and cannot be stabilized. The stability of isopropylmethylphenol improves as the fluorine concentration increases, but if it exceeds 3,000 ppm, the appearance stability of the pharmaceutical product deteriorates.
Within the range of the content as fluorine, specifically, the content of sodium fluoride is preferably 0.25 to 0.66% of the whole composition, and the content of sodium monofluorate is contained. The amount is preferably 0.84 to 2.27% of the total composition.

The dentifrice composition of the present invention is suitably prepared as a dentifrice such as dentifrice and liquid dentifrice, particularly as a dentifrice, and depending on the dosage form, other known components in addition to the above components do not interfere with the effect of the present invention. Can be blended in a range. Specifically, it may contain an abrasive, a thickener, a binder, a sweetener such as sodium saccharin, a preservative such as paraoxybenzoic acid ester or a salt thereof, a coloring agent such as titanium oxide, a fragrance, and an active ingredient. ..
It is not necessary to add a surfactant other than an anionic surfactant and a nonionic surfactant, but a cationic surfactant and an amphoteric surfactant are added within a range that does not interfere with the effect of the present invention. You may.

Examples of the polishing agent include silica-based polishing agents such as anhydrous silicic acid and hydrous silicic acid, calcium phosphate-based polishing agents such as calcium hydrogen phosphate, calcium carbonate, zeolite, calcium pyrophosphate, aluminum hydroxide, alumina, hydroxyapatite, and carbonic acid. Examples thereof include magnesium, tertiary magnesium phosphate, zirconium silicate, and crystalline cellulose. In particular, a silica-based abrasive and a calcium phosphate-based abrasive are preferable from the viewpoint of usability, and among them, the silica-based abrasive anhydrous silicic acid is more preferable from the viewpoint of sufficiently exhibiting the effect of the fluorine compound.
Further, when silicic anhydride having a BET specific surface area of preferably 50 to 400 m ² / g, more preferably 80 to 250 m ² / g is used, a sufficient cleaning effect can be provided while reducing the polishability. .. The BET specific surface area is a value measured based on the Japanese Industrial Standards (JIS8830).
The content of the abrasive is preferably 5 to 40%, more preferably 5 to 20% of the total composition.

Examples of the thickener include sugar alcohols such as sorbitol and propylene glycol. The blending amount of the thickener is usually 5 to 50%, particularly 20 to 45%.

Examples of the binder include alginic acid derivatives such as sodium polyacrylate and sodium alginate, cellulosic derivatives such as sodium carboxymethyl cellulose, organic binders such as gums such as xanthan gum, and inorganic binders. The blending amount of the binder is usually 0.1 to 5%.

As fragrances, peppermint oil, spare mint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, distilling, liquid extraction, essence, powder Fragrances (such as fragrances), and menthol, carboxylic, anator, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, timole, linalol, linalyl acetate, limonene, Menton, Menthyl Acetate, N-Substituted Paramentan-3-Carboxamide, Pinen, Octylaldehyde, Citral, Pregon, Calvier Acetate, Anisaldehyde, Ethyl Acetate, Ethyl Butyrate, Allyl Cyclohexane Propionate, Methyl Anthranilate, Ethyl Single flavors such as methylphenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, flufural, trimethylpyrazine, ethyllactate, ethylthioacetate, as well as strawberry flavor, apple flavor, banana Although known perfume materials used in oral compositions can be used in combination, such as flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, fruit mix flavors, and tropical fruit flavors. , The fragrance is not limited to the fragrances described in the examples.
It is preferable to use 0.000001 to 1% of the above fragrance material in the formulation composition, and 0.1 to 2% of the fragrance for perfume using the above fragrance material is used in the formulation composition. preferable.

As active ingredients, isopropylmethylphenol, medicinal ingredients known for oral use other than fluorine compounds, specifically, cationic bactericides, anti-inflammatory agents, enzymes, plant extracts, tartar inhibitors, plaque inhibitors, etc. , An effective amount can be blended within a range that does not interfere with the effects of the present invention.

The dentifrice composition of the present invention is suitably filled in a tube container whose innermost layer is made of polyethylene.
Examples of such a container include low-density polyethylene / ethylene / acrylic acid copolymer resin / aluminum / ethylene / acrylic acid copolymer resin / linear low-density polyethylene (innermost layer), low-density polyethylene / ethylene, from the outer layer. Vinyl alcohol copolymer / low density polyethylene / ethylene / vinyl alcohol copolymer / linear low density polyethylene (innermost layer), and low density polyethylene / polyethylene terephthalate / low density polyethylene / glass vapor deposition polyethylene terephthalate / ethylene Examples thereof include those having a laminated layer structure made of a methacrylic acid copolymer resin / linear low-density polyethylene (innermost layer), but if the innermost layer is polyethylene, any other layer structure may be used, and in particular, the innermost layer. Is preferably linear low-density polyethylene.

The linear low-density polyethylene is also referred to as linear low-density polyethylene, and as a manufacturing method, α-olefin (for example, butene-1, hexene-1, 4-methylpentene) is added to the linear polymer in the high-density polyethylene manufacturing process. , Octen-1) is copolymerized and short chain branching is introduced to reduce the density, and the linear low density polyethylene for extrusion coating has a density of 0.915 to 0.938 g / cm ³ . Is commonly used.
The thickness of polyethylene in the innermost layer is not particularly specified, but usually has a thickness of about 30 to 100 μm, and the entire laminated layer having a thickness of 200 to 450 μm is usually used.
In the above-mentioned tube container, the compounding components in the contents are easily adsorbed particularly on the content discharge port and the shoulder portion connecting the body portion, particularly on the shoulder portion, but in the present invention, the innermost layer of each of the above-mentioned portions is polyethylene. However, the adsorption of isopropylmethylphenol is suppressed and the stability is excellent.

As such a tube container whose innermost layer is made of polyethylene, a commercially available one can be used, and for example, it can be obtained as a toothpaste tube from a container packaging material manufacturer such as Dai Nippon Printing Co., Ltd. or Toppan Printing Co., Ltd.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Toothpaste compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method, filled in a tube container as shown below, and evaluated as a test toothpaste composition by the following method. The results are also shown in Tables 1 to 3.

Preparation of test toothpaste composition Toothpaste composition was prepared by laminating a 26 mm diameter laminated tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30, thickness 257 μm) in which the innermost layer was made of linear low-density polyethylene. (Manufactured by Dai Nippon Printing Co., Ltd.)) was filled with 60 g.
The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low-density polyethylene White LDPE: White Low-density polyethylene LLDPE: Linear low-density polyethylene AL: Aluminum EAA: Polyethylene / acrylic acid copolymer resin PET: Polyethylene terephthalate EMA: Ethylene / methacrylic acid copolymer resin SiOx -PET: Glass-deposited polyethylene terephthalate

(1) Method for evaluating stability of isopropylmethylphenol The amount of isopropylmethylphenol was measured by HPLC using HPLC according to the following test conditions for the dentifrice composition after storage at 60 ° C. for 1 month. The residual rate when the amount of isopropylmethylphenol immediately after production of each sample was set to 100% was calculated, the stability of isopropylmethylphenol was determined according to the following criteria, and the stability was shown in the table as IPMP stability.
Test condition;
-Detector: Ultraviolet absorptiometer (measurement wavelength: 285 nm)
-Column: YMC-Pack ODS-A A-303 (4.6 mmφ x 250 mm)
-Column temperature: 45 ° C
-Mobile phase: Acetonitrile / water / acetic acid mixed solution (60:40: 1)
Used equipment;
-Pump: JASCO Corporation, PU-980
-Sample introduction section: JASCO Corporation, AS-950
-Detector: JASCO Corporation, UV-970
-Column constant temperature bath: JASCO Corporation, CO-960
・ Flow rate: 1 mL / min
criterion;
⊚: 97% or more and 100% or less ○: 94% or more and less than 97% Δ: 90% or more and less than 94% ×: less than 90%

(2) Method for evaluating the appearance stability of the pharmaceutical product The dentifrice composition after being stored at 60 ° C. for 1 month was discharged on a straw paper by about 15 cm. Based on the length of the water soaked into the back of the straw paper, the liquid separation stability was evaluated according to the following criteria.
Judgment criteria ◎: Less than 0.2 cm ○: 0.2 cm or more and less than 0.5 cm ×: 0.5 cm or more

(3) Evaluation method of foaming The toothpaste composition was placed on a toothbrush, and the foaming when the oral cavity was washed was evaluated by 5 subjects according to the following scoring criteria. The evaluation points of 5 persons were averaged, and the foaming was evaluated according to the following criteria.
Score criteria;
5 points: Good foaming 4 points: Slightly good foaming 3 points: Neither can be said 2 points: Slightly bad foaming 1 point: Poor foaming criteria;
⊚: Average score 4.0 points or more ○: Average score 3.0 points or more and less than 4.0 points Δ: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

As is clear from the results in Tables 1 to 3, when the components (B) and (C) are blended together with the component (A) as shown in the comparative example, the IPMP stability deteriorates, and the component (D) is added. If the blending amount or the (B) / (C) ratio is inappropriate, the IPMP stability will be inferior, but the component (D) will be added to the components (A), (B) and (C) in an appropriate amount and appropriate ( The toothpaste composition (Example) of the present invention blended in combination within the range of B) / (C) was excellent in IPMP stability, appearance stability of the preparation, and foaming. The taste after brushing the teeth was also good.

Claims (10)

(A) 0.02 to 0.3% by mass of isopropylmethylphenol,
(B) Sodium lauryl sulfate in an amount of 0.6 to 1.8% by mass,
(C) 1.0 to 2.5% by mass of polyoxyethylene hydrogenated castor oil having an average addition mole number of 20 to 100 of ethylene oxide.
(B) / (C) as a mass ratio of 0.4 to 1.3, and (D) a fluorine compound was added to a toothpaste composition filled in a container having an innermost layer made of linear low-density polyethylene. A toothpaste composition comprising 1,400 to 2,500 ppm of fluorine as fluorine. The toothpaste composition according to claim 1, wherein the component (D) is blended as an inhibitor for the adsorption of the component (A) to the innermost layer of the container. The toothpaste composition according to claim 1 or 2, wherein (B) / (C) is 0.5 to 1.2 in mass ratio. The dentifrice composition according to any one of claims 1 to 3, further comprising 5 to 40% by mass of an abrasive. Dentifrice composition according to any one of claims 1-4 is for inhibiting adsorption of isopropyl methylphenol to the innermost layer of the container in dentifrices composition. The toothpaste composition according to any one of claims 1 to 5, which is a toothpaste. (A) 0.02 to 0.3% by mass of isopropylmethylphenol,
(B) Sodium lauryl sulfate in an amount of 0.6 to 1.8% by mass,
(C) 1.0 to 2.5% by mass of polyoxyethylene hydrogenated castor oil having an average addition mole number of 20 to 100 of ethylene oxide.
(B) / (C) as a mass ratio of 0.4 to 1.3, and the fluorine compound (D) was added to the toothpaste composition filled in a container whose innermost layer was made of linear low-density polyethylene. 1,400 to 2,500 ppm as fluorine
A method for suppressing the adsorption of isopropylmethylphenol on the innermost layer of a container in the dentifrice composition, which comprises blending. The method for suppressing the adsorption of isopropylmethylphenol on the innermost layer of a container in the toothpaste composition according to claim 7, wherein (B) / (C) has a mass ratio of 0.5 to 1.2. Further, the method for suppressing adsorption of isopropylmethylphenol to the innermost layer of a container in the toothpaste composition according to claim 7 or 8 , which is a toothpaste composition containing 5 to 40% by mass of an abrasive. The method for suppressing the adsorption of isopropylmethylphenol on the innermost layer of a container in the toothpaste composition according to any one of claims 7 to 9, wherein the toothpaste is a toothpaste.