JP2007084471A - Composition for oral cavity and method of selecting product for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for oral cavity, having preventing and suppressing effects for dental caries, periodontosis and the like and excellent in refrigerant feeling, and to provide a method for selecting the most proper product for oral cavity, corresponding to oral cavity state and symptoms even if having no expertise. <P>SOLUTION: The composition for oral cavity contains one or more antibacterial agent selected from a group consisting of cetylpyridinium chloride, a chlorhexidine salt, hexetidine, dequalinium chloride, benzalkonium chloride and benzethonium chloride, and Mentha arvensis extracts. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to oral compositions and methods for selecting oral products suitable for treatment of conditions and / or symptoms in the oral cavity of a subject.

  As an oral composition, a dentifrice and a mouthwash are common. However, in recent years, chewing gums, wrinkles, tablets, supplements, and mouse sprays that have a preventive or suppressive action against caries and periodontal diseases are sometimes included in oral compositions. In addition to these preventive and inhibitory effects, oral compositions are also required to have a refreshing feeling and a bad breath suppressing action.

  For example, since the composition for mouse spray described in Patent Document 1 is oily, a relatively large amount of fat-soluble fragrance can be blended without using a surfactant that impairs the flavor, and the refreshing feeling is enhanced. It is what.

  In addition, as described above, various functions are required for oral compositions, and commercially available oral compositions are also various. In addition to oral compositions, various types of oral appliances such as toothbrushes, interdental brushes, and dental floss have been developed. Therefore, it is difficult to select an oral product that is optimal for the condition and symptoms in the oral cavity unless there is advice from a specialist such as a dentist.

Under such circumstances, Patent Document 2 discloses a technique that can easily make a comprehensive risk determination of oral disease. The technology relates to a risk improvement table having a risk estimation unit for estimating the risk of oral disease and a presentation unit for risk avoidance measures, and appropriate risk avoidance measures are obtained based on the obtained determination results. It is done.
JP 2003-286144 A (Claims, Examples) JP 2001-46381 A (Claims)

  As described above, various effects have been required for oral compositions, and oral compositions having a refreshing feeling are required. In addition, in the situation where not only oral compositions but also a wide variety of oral products are distributed in the market, there has been a technology that can present risk avoidance measures according to risks such as oral diseases. However, it is not a method that can directly select an optimal oral product according to the condition and symptoms in the oral cavity.

  Therefore, the problem to be solved by the present invention is to provide an oral composition having an effect of preventing or suppressing caries and periodontal diseases and having an excellent refreshing feeling. Another object of the present invention is to provide a method capable of selecting an optimal oral product according to the condition and symptoms in the oral cavity without having specialized knowledge.

  In order to solve the above-mentioned problems, the present inventors proceeded with studies on the component constitution of the oral composition. As a result, even when an antibacterial agent that impairs the flavor was blended, the present invention was completed by finding that an oral composition having a refreshing feeling can be obtained by adding a Japanese mint extract.

That is, the composition for oral cavity of the present invention is
It contains one or more antibacterial agents selected from the group consisting of cetylpyridinium chloride, chlorhexidine salt, hexetidine, decalinium chloride, benzalkonium chloride and benzethonium chloride, and a Japanese mint extract.

  As the antibacterial agent, cetylpyridinium chloride and / or chlorhexidine salt is preferable. This is because these antibacterial agents have particularly high antibacterial activity against causative bacteria of caries and periodontal diseases.

  In addition, one or more active ingredients selected from the group consisting of vitamin E, vitamin E derivatives, glycyrrhizic acid, glycyrrhizinate, tranexamic acid, potassium nitrate, aluminum lactate, sodium fluoride, monofluorophosphate Is preferably blended. This is because the value of the composition for oral cavity can be increased by further blending an active ingredient that is effective for treating caries and periodontal diseases.

  As the composition for oral cavity, one further containing a nonionic surfactant is preferable. This is because the stability of the liquid or liquid composition is particularly enhanced. Further, as the wetting agent, one containing three or more kinds of mixtures selected from the group consisting of glycerin, sorbitol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polyethylene glycol and polypropylene glycol is preferable. Each of these wetting agents has excellent characteristics, but by mixing three or more kinds, it becomes possible to make up for each other's drawbacks while making use of the characteristics of each wetting agent, making formulation easier, etc. The effect is obtained.

  Examples of the dosage form of the oral composition according to the present invention include toothpastes, liquid dentifrices, liquid dentifrices, mouthwashes, and mouse sprays as representative examples. In particular, a mouse spray containing 30% by mass or more of ethanol is excellent in a refreshing feeling.

  In addition, the present inventors have also found that the above problem can be solved by using a database capable of linking data such as the condition in the oral cavity of the subject and an oral product optimal for the treatment.

That is, the first method for selecting an oral product according to the present invention is as follows.
A method of selecting an oral product suitable for treatment of a condition and / or symptoms in a subject's oral cavity, comprising:
Obtaining data on the condition and / or symptoms in the oral cavity of the subject and inputting the data to a computer;
A step of selecting one or more oral products suitable for treatment of a condition and / or symptoms in the oral cavity of a subject from a database by a computer and outputting the selected oral products (hereinafter, “output step”) )
It is characterized by including.

In addition, the second method for selecting an oral product according to the present invention is as follows.
A method of selecting an oral product suitable for treatment of a condition and / or symptoms in a subject's oral cavity, comprising:
Obtaining one or more types of data suitable for the treatment of conditions and / or symptoms in the oral cavity of the subject, and obtaining data on the subject's oral conditions and / or symptoms and recording the data in a data sheet; A step of selecting an oral product from a database in accordance with the data recorded in the data sheet (hereinafter referred to as “selection step”),
It is characterized by including.

  As the above-mentioned database, those having data on the condition and / or symptom in the oral cavity, components suitable for the treatment, and the component composition of the composition for oral cavity are used, and suitable for the treatment of the condition and / or symptom in the oral cavity. The aspect which outputs or selects the composition for oral cavity selected as is suitable.

  In the above method, the database further includes data on the dosage form, usage, usage amount and / or precautions of the oral composition suitable for treatment of oral conditions and / or symptoms. In the output step or the selection step, together with the selected oral product, an aspect of outputting or selecting one or more data relating to the dosage form, usage, usage amount and / or usage precautions, and the database, Using an oral appliance suitable for treatment of conditions and / or symptoms in the oral cavity, data having specifications, usage and / or usage precautions, in the above output step or selection step, the oral appliance, its specification, Output one or more data regarding usage and / or usage precautions or Manner of-option is also suitable.

  The subject's oral condition and / or symptom data includes interviews, occult blood tests, bacterial tests, biochemical mediator tests, biomarker tests, x-ray tests, dental clinical indicators, plaque clinical indicators and periodontal disease Conveniently obtained by one or more means selected from the group consisting of clinical indicators.

  The composition for oral cavity of the present invention has an effect of preventing and suppressing caries and periodontal diseases and is also excellent in a refreshing feeling. Therefore, the composition for oral cavity of the present invention is very useful as having excellent usability. In addition, the method of the present invention is useful as a method for selecting an optimal oral product according to the condition and symptoms in the oral cavity without having specialized knowledge.

The composition for oral cavity of the present invention is
It contains one or more antibacterial agents selected from the group consisting of cetylpyridinium chloride, chlorhexidine salt, hexetidine, decalinium chloride, benzalkonium chloride and benzethonium chloride, and a Japanese mint extract.

  The antibacterial agents used in the present invention, cetylpyridinium chloride, chlorhexidine salt, hexetidine, decalinium chloride, benzalkonium chloride and benzethonium chloride are all classified as cationic antibacterial agents. These cationic antibacterial agents have the disadvantage of impairing the flavor of the composition while having excellent antibacterial activity against bacteria causing caries and periodontal diseases. However, in this invention, the refreshing feeling of the whole composition is improved by mix | blending Japanese seed mint extract as a fragrance | flavor.

  One type of the antibacterial agent of the present invention may be selected from the above group, or two or more types may be used in combination. Preferably, cetylpyridinium chloride or chlorhexidine salt, or a mixture of cetylpyridinium chloride and chlorhexidine salt is used. These are excellent as antibacterial agents against bacteria causing caries and periodontal diseases.

  The blending amount of the antibacterial agent with respect to the entire composition of the present invention is preferably 0.01% by mass or more and 0.5% by mass or less. If it is less than 0.01% by mass, the antibacterial action may not be sufficiently exhibited, while if it exceeds 0.5% by mass, the flavor of the composition may be lowered.

  The extract of Japanese species mint (Mentha arvensis) used in the present invention uses oil refinement obtained from Japanese species mint by the steam distillation method, but in addition to oil production, a solvent using water, an organic solvent, liquid carbon dioxide gas, or the like. Extracts obtained by the extraction method, oleoresin, and the like can also be used as necessary.

  The Japanese mint extract of the present invention may be used alone or in combination with other perfume ingredients. Other perfume ingredients used in combination with Japanese mint extract include, for example, vanillin, anethole, benzyl succinate, carvone, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, menthyl Examples include acetate, citronellyl acetate, methyl eugenol, cineol, linalool, ethyl linalool, and thymol. Moreover, you may mix | blend the fat-soluble extract of other plants. As perfumes that are such vegetable fat-soluble extracts, thyme oil, nutmeg oil, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, winter green oil Eucalyptus oil, basil oil, tea tree oil, tabana oil and the like.

  The blending amount of the fragrance added to the oral composition of the present invention, that is, the Japanese mint extract, is preferably 0.1% by mass or more and 2% by mass or less with respect to the whole composition. If the amount is less than 0.1% by mass, the effect may not be sufficiently exhibited. On the other hand, if the amount exceeds 2% by mass, stimulation may become stronger. As described above, the Japanese mint extract may be combined with other fragrance ingredients, and the other fragrance ingredients may contain the Japanese mint extract. It is preferable that the amount of mint is relatively small, and more preferably, the total amount of the fragrance is within the above range.

  In addition to the antibacterial activity or in addition to the antibacterial activity, the oral composition of the present invention may be blended with components having further medicinal effects. Examples of such active ingredients include vitamin E, vitamin E derivatives, glycyrrhizic acid, glycyrrhizinate, tranexamic acid, potassium nitrate, aluminum lactate, sodium fluoride, and monofluorophosphate. Of these active ingredients, vitamin E and vitamin E derivatives promote blood circulation. Glycyrrhizic acid and glycyrrhizinate have anti-inflammatory analgesic effects. Tranexamic acid has a hemostatic effect. Potassium nitrate and aluminum lactate have a stimulus-suppressing action. Sodium fluoride and monofluorophosphate release fluoride ions in the oral cavity, and this fluoride ions promote tooth remineralization.

  The active ingredient of the present invention may be used by selecting one from the above group, or may be used in combination after selecting two or more.

  The compounding amount of the active ingredient varies depending on the type of the active ingredient. For example, the blending amount of vitamin E, vitamin E derivative or tranexamic acid is preferably 0.01% by mass or more and 0.5% by mass or less based on the entire composition. The blending amount of glycyrrhizic acid or glycyrrhizinate is preferably 0.005% by mass or more and 0.05% by mass or less. 1 mass% or more and 10 mass% or less are suitable for the compounding quantity of potassium nitrate or aluminum lactate. A suitable blending amount of sodium fluoride or monofluorophosphate is preferably 0.05% by mass or more and 0.2% by mass or less as fluoride ions.

You may mix | blend a nonionic surfactant further to the composition for oral cavity of this invention. In particular, when the oral composition is a liquid preparation, it is preferably blended. The type is not particularly limited as long as it is conventionally used for oral cavity. For example, polyoxyethylene fatty acid ester such as polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monolaurate, polyoxyethylene Hydrogenated castor oil, lauric acid monoethanolamide, myristic acid monoethanolamide, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester alkyl glycoside (eg alkyl chain: C _{8 -16} ), polyglycerin fatty acid ester (for example, alkyl chain of fatty acid portion: about C _8-16 ), sucrose fatty acid ester (for example, alkyl chain of fatty acid portion: about C _8-16 ), and the like. Among these, polyoxyethylene addition type surfactants are preferred, and polyoxyethylene addition selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene sorbitan fatty acid ester A type of surfactant is more preferred.

  The blending amount of the nonionic surfactant with respect to the entire composition of the present invention is preferably 0.1% by mass or more and 1% by mass or less. If the amount is less than 0.1% by mass, a sufficient stabilizing effect may not be exhibited. On the other hand, if it exceeds 1% by mass, the feeling in use may be impaired.

  You may mix | blend a wetting agent with the composition for oral cavity of this invention. In particular, when the oral composition is a toothpaste or a liquid dentifrice, it is preferably blended. The type of the wetting agent is not particularly limited, and examples thereof include glycerin, sorbitol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polyethylene glycol, and polypropylene glycol. As the wetting agent to be blended, one or more of these can be selected and used, but a mixture of three or more is preferably used. Even if one type of wetting agent is effective, it is possible to make up for the disadvantages of the respective wetting agents by combining three or more types of wetting agents.

  For example, sorbitol is a common wetting agent, but may form aggregates when formulated into a composition with water. Then, since the addition amount of water can be reduced by adding glycerin, the formation of the said aggregate can be suppressed as a result. However, when the amount of glycerin added is increased, the viscosity increases too much and uniform mixing may become difficult. In that case, propylene glycol, ethylene glycol, 1,3-butylene glycol, polyethylene glycol or polypropylene glycol may be added to adjust the viscosity. Moreover, when there are too many compounding quantities, such as these propylene glycols, irritation | stimulation may become strong. Therefore, such stimulation can be suppressed by adding sorbitol or glycerin.

  A combination of three or more of the above, ie, one selected from the group consisting of (1) sorbitol, (2) glycerin, and (3) propylene glycol, ethylene glycol, 1,3-butylene glycol, polyethylene glycol, and polypropylene glycol Or it is preferable that the addition ratio of 2 or more types of mixtures shall be about (1) 10-30: (2) 2-8: (3) 1-5 grade suitably. Further, the blending amount of the wetting agent with respect to the entire composition is 5% by mass or more and 20% by mass or less in the case of a liquid or liquid composition, and 20% by mass or more and 40% by mass in the case of a solid composition such as a toothpaste paste. The following are preferred.

  The composition for oral cavity of the present invention is a dentifrice, liquid dentifrice, liquid dentifrice, powder dentifrice, mouthwash, mouse spray, gel, profi paste, pasta, chewing gum, patch, sealant, tablet, etc. However, toothpastes, liquid dentifrices, liquid dentifrices, mouth washes or mouth sprays are particularly preferred from the viewpoint of usability.

  In the composition for oral cavity of the present invention, water, lower alcohol, higher alcohol and additives usually used in the field can be appropriately blended in addition to the above essential components depending on the dosage form. Examples of such additives include abrasives, excipients, foaming agents, fragrances, sweeteners, binders, pH adjusters, wetting agents, preservatives, coloring agents, various medicinal ingredients, and the like. It can mix | blend in the range which is not impaired.

  The amount of water can be appropriately set according to the dosage form, etc., but in the case of a liquid or liquid composition, it is about 40 to 90% by mass, and in the case of a solid composition such as a toothpaste, it is 10 to 30% by mass. Degree. The blending amount of alcohol such as ethanol is usually about 0 to 60% by mass with respect to the whole composition, but is particularly preferably 30% by mass or more, particularly in the case of a mouse spray that requires a refreshing feeling. It is about 30-50 mass%. In the case of a composition other than mouse spray, 0 to 20% by mass is preferable, more preferably 0 to 10% by mass, and still more preferably 0 to 5% by mass.

  When the composition of the present invention is used as a dentifrice, dibasic calcium phosphate dihydrate and anhydrous, calcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silica gel, aluminum silicate Precipitating silica, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin, and the like can be used. These abrasives may be used alone or in combination of two or more, and the blending amount is usually about 5 to 90% by mass relative to the total weight of the composition, and 5 to 50 in the case of toothpaste. It is about mass%.

  Examples of the excipient include silica such as igneous silica and thickening silica (generally indicating silica having an RDA value of about 30 or less), powdered cellulose such as carboxymethyl cellulose, crystalline cellulose, and the like. Two or more kinds may be mixed and used. Of these, silica is preferred. The blending amount of the excipient is usually about 0.1 to 30% by mass, preferably about 0.5 to 10% by mass with respect to the total weight of the composition.

In addition to the nonionic surfactants described above, amphoteric surfactants and anionic surfactants that are usually used in oral compositions may be blended. Examples of such surfactants include N-alkyldiaminoethylglycine, alkylbetaine, fatty acid amidopropylbetaine (for example, alkyl chain of fatty acid moiety: about C _8-16 ), alkylsulfobetaine, alkylbetaine, imidazolinium. Amphoteric surfactants such as betaine; higher alkyl sulfates having 8 to 18 carbon atoms in the alkyl group, such as sodium lauryl sulfate and sodium myristyl sulfate; sulfosuccinic acid surfactants; N-lauroyl sarcosine sodium and N-myristoyl N-acyl sarcosine sodium such as sarcosine sodium; N-long chain acyl amino acid salt; α-olefin sulfonate salt; higher fatty acid sodium monoglyceride monosulfate; N-methyl-N-palmitoyl tauride salt; Examples thereof include anionic surfactants such as rumate, sodium N-methyl-N-acyl taurine, sodium N-methyl-N-acylalanine, and sodium α-olefin sulfonate.

  As the binder, cellulose derivatives such as sodium carboxymethiscellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose; propylene glycol ester of alginic acid; gums such as xanthan gum, alginic acid and its salt, tragacanth gum, caraya gum, gum arabic, carrageenan; polyvinyl alcohol And synthetic binders such as sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone. A binder may be used independently or may use 2 or more types together. The compounding quantity is about 0.3-5 mass% normally with respect to the whole composition.

  Examples of the sweetener include saccharin sodium, trehalose, stevioside, acesulfame K, glycyrrhizin or a salt thereof, perilartin, thaumatin, aspartylphenylalanine methyl ester, xylitol, palatinose, palatinit, erythritol, maltitol and the like. Sweetening agents may be used alone or in combination of two or more. The compounding quantity of a sweetener is about 0.01-5 mass% normally with respect to the whole composition.

  Examples of the pH adjuster include phosphoric acid and salts thereof (sodium phosphate, sodium hydrogen phosphate, etc.), citric acid and salts thereof (sodium, etc.), malic acid and salts thereof, gluconic acid and salts thereof, maleic acid and Its salts, aspartic acid and its salts, gluconic acid and its salts, succinic acid and its salts, glucuronic acid and its salts, fumaric acid and its salts, glutamic acid and its salts, adipic acid and its salts, hydrochloric acid, sodium hydroxide, Examples thereof include potassium hydroxide and sodium silicate. A pH adjuster may be used independently or may use 2 or more types together. Although the compounding quantity of a pH adjuster will not be restrict | limited especially as long as it becomes desired pH, It is about 0.01-5 mass% normally with respect to the whole composition, Preferably it is about 0.1-3 mass%. The pH of the composition of the present invention is not particularly limited as long as the effect of the present invention is exerted, but is usually about 4 to 10, and preferably about 5.5 to 9.

  Examples of preservatives include benzoates such as sodium benzoate; parabens such as methylparaben and butylparaben. A preservative may be used independently or may use 2 or more types together. The compounding amount of the preservative is usually about 0.01 to 3% by mass with respect to the whole composition.

  Examples of the colorant include legal dyes such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3; mineral dyes such as ultramarine blue, enhanced ultramarine blue, and bitumen; and titanium oxide. A colorant may be used independently or may use 2 or more types together. The compounding quantity of a coloring agent is about 0.0001-1 mass% normally with respect to the whole composition.

  The composition for oral cavity of this invention can be manufactured by the conventional method matched with the dosage form. For example, a water-soluble blending component is dissolved in water or a mixture of water and a wetting agent to obtain an aqueous solution. Further, a water-insoluble component such as an abrasive may be added to form a dispersion. A surfactant, fragrance, oil-soluble component, lower alcohol, etc. are added to this aqueous solution or dispersion. These additive components may be added in advance or separately. If viscosity is required for the oral composition, a binder is added and stirred. If defoaming is necessary, the mixture is stirred in a vacuum. However, the method for producing the composition for oral cavity according to the present invention is not limited to the above-described method, and an optimal method may be selected according to the dosage form, its formulation, and the like.

The first method for selecting an oral product according to the present invention is a method for selecting an oral product suitable for treatment of a condition and / or symptoms in the oral cavity of a subject,
Acquiring data on the condition and / or symptoms in the oral cavity of the subject and inputting the data to a computer (hereinafter referred to as “data input step”);
Selecting one or more oral products suitable for treatment of conditions and / or symptoms in the oral cavity of the subject from a database by a computer and outputting the selected oral products (output step);
It is characterized by including. Hereinafter, embodiments of the method of the present invention will be described with reference to the drawings.

Data Input Step First, data on the condition and symptoms in the oral cavity of the subject is acquired. Specifically, for example, answers to questions related to caries and periodontal diseases (interview results), occult blood test results, bacterial test results related to caries and periodontal diseases, and caries and periodontal diseases In the oral cavity in light of biochemical mediator test results, biomarker test results related to dental caries and periodontal disease, X-ray test results, clinical indicators related to teeth, clinical indicators related to plaque, or clinical indicators related to periodontal disease Status data and symptom data. The acquired data is input to the computer. The "input" to this computer may be one that inputs data recorded on a predetermined data sheet, or one that can be input by reading data in a format like a mark sheet. Good.

  Here, “subject” means not only patients who feel discomfort or abnormalities in the oral cavity or purchasers of oral products, but also patients who have oral symptoms such as periodontal disease but have no subjective symptoms. Or a person including a person who has no subjective symptom or disease or a person who has a test for oral condition. In addition, when a subject does not have abnormality in an oral cavity, of course, a suitable oral product may not be selected.

Output step Based on the input data, one or more oral products suitable for treatment of conditions and symptoms in the oral cavity of the subject are selected from the database by the computer. The “oral product” herein is not particularly limited as long as it can be used for treatment of the condition and symptoms in the oral cavity of the subject. For example, the oral composition; a toothbrush, an interdental brush, Examples include interdental cleaning tools such as dental floss and oral appliances such as an irrigator.

  The database has data on at least oral conditions and / or symptoms, components suitable for the treatment, and component composition of the oral composition. Therefore, the computer can first select a component related to the condition and symptom in the oral cavity of the subject from the database, and then select an oral composition having the component.

  In addition, the database may include data relating to the dosage form, usage, usage amount and / or precautions of the oral composition suitable for treatment of the condition and symptoms in the oral cavity of the subject. For example, when a plurality of oral compositions are selected, an optimal composition can be selected in consideration of the dosage form. Depending on the dosage form, there may be a plurality of usages, and the effect may vary depending on the amount used. Therefore, if the database has usage and usage data, the optimal usage and usage can be selected for treatment of the condition and symptoms in the oral cavity of the subject. Here, the “usage” includes, for example, an oral appliance for applying the oral composition, a method for using the oral composition, a use time, and the like. Oral appliances can also be selected depending on the type of oral composition used.

  In addition, the database relates to conditions and / or symptoms in the oral cavity and oral appliances suitable for the treatment, their specifications, usage and / or precautions independent of oral appliances suitable for oral compositions. Those having data are preferred. For example, when cleaning between teeth, oral appliances according to the condition in the oral cavity such as dental floss when the gap between teeth is narrow, and interdental brush when the gap is wide can be selected. In addition, the specifications of the oral appliance can be further selected, such as selecting a dental floss made of polytetrafluoroethylene when the gap is narrow and using a wide dental floss when the gap is relatively wide. Other specifications for oral appliances include toothbrush hardness (soft and stiff), bristles (usually tapered, feathered, etc.), flocked surfaces (flats, chops, etc.); The whole drive system (manual, electric, sonic type, ultrasonic type); the shape of the irrigator chip in the irrigator (for gingival margin or subgingival margin) can be mentioned.

  The computer is the cause of the condition and symptoms in the oral cavity of the subject based on the input data and the correlation with caries and periodontal disease, algorithm such as decision tree, pattern recognition, etc. It is preferable to determine the priority of the condition to be treated in consideration of the activity, severity, and risk of the disease. Next, a component necessary to deal with it is selected from a high priority state or the like, and an oral product having the component is selected. In addition, as described above, it is also preferable to select a dosage form of an oral composition suitable for treatment of a high priority state or the like, its usage, its use amount, and an oral appliance. For example, if the condition to be dealt with most preferentially is bleeding, an effective ingredient for hemostasis is selected, and then an oral composition containing the active ingredient is selected. Moreover, you may select the goods set (system) containing not only an oral composition but the instrument for applying it.

  Finally, the oral product selected as suitable for treating the condition and symptoms in the subject's oral cavity is output. At that time, if the database has not only the composition of the composition for oral cavity but also its dosage form and data on oral appliances, etc., select the most suitable combination for the condition and symptoms in the oral cavity. Can do. Therefore, it becomes possible to know the oral product and the combination thereof that are optimal for the treatment of the state of the subject's oral cavity and the like without having specialized knowledge.

The second method for selecting an oral product according to the present invention is a method for selecting an oral product suitable for treatment of a condition and / or symptoms in the oral cavity of a subject,
Obtaining one or more types of data suitable for the treatment of conditions and / or symptoms in the oral cavity of the subject, and obtaining data on the subject's oral conditions and / or symptoms and recording the data in a data sheet; Selecting an oral product from a database according to the data recorded in the data sheet (selection step);
It is characterized by including.

  In the second selection method, similar to the data input step of the first method, data on the condition and symptoms in the oral cavity of the subject is acquired and recorded on a data sheet. Although the subject person may fill in the data sheet, there is no particular limitation, and the dentist or a person following the data sheet may do so.

  Next, according to the data recorded on the data sheet, one or more oral products suitable for treatment of the condition and / or symptoms in the oral cavity of the subject are selected from the database. This database is the same as that described in the first method. This selection step is the same as the step of selecting the oral product in the output step of the first selection method. However, in the first method, since a suitable oral product is selected by a computer, the database needs to be electronic data. However, in the second method, the database is not limited to this, and may be written.

  The selected oral product may be purchased by the subject himself / herself, but may be prepared by a pharmacist or the like, and the route to reach the subject is not particularly limited.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited by the following examples, but may be appropriately modified within a range that can meet the purpose described above and below. It is also possible to implement, and they are all included in the technical scope of the present invention.

Example 1 Dentifrice With the composition shown in Table 1, a toothpaste was prepared according to a conventional method.

  The toothpaste contains cetylpyridinium chloride, which exhibits excellent antibacterial activity against germs that cause caries and periodontal disease, and tocopherol acetate that promotes blood circulation, and further monofluoroline that promotes remineralization of teeth. It is an excellent composition for oral cavity containing sodium acid. In addition, since it has an appropriate amount of herb-based fragrance containing Japanese mint extract, its flavor was also good.

Example 2 Mouthwash and mouse spray With the composition shown in Table 2, a mouthwash (No. 1-3) and a mouse spray (No. 4) were prepared according to a conventional method.

  No. 1 to 4 mouthwashes and mouse sprays contain cetylpyridinium chloride which exhibits excellent antibacterial activity against germs causing caries and periodontal disease. No. No. 1 mouthwash has glycyrrhizic acid that exhibits anti-inflammatory action. No. 2 mouthwash has tranexamic acid showing hemostatic action, No. 2 No. 3 mouthwash has potassium nitrate which shows an irritation suppressing action and sodium fluoride which promotes remineralization of teeth. Therefore, an effective treatment can be performed by selecting these compositions according to the swelling of the gums, the presence or absence, hypersensitivity, the presence or absence of caries, and the like. In addition, since each composition has an appropriate amount of a fragrance containing a Japanese mint extract, its flavor was also good.

Example 3 Mouthwash With the composition shown in Table 3, a mouthwash (No. 5 to 12) was prepared according to a conventional method.

  Since the mouthwash has an excellent antibacterial agent such as chlorhexidine gluconate and an appropriate amount of a fragrance containing a Japanese mint extract, the flavor was also good.

Example 4 Mouthwash and mouse spray With the composition shown in Table 4, mouse sprays (No. 13 to 15) were prepared.

  The above-mentioned mouse spray also has excellent antibacterial properties and also has a good flavor because it has an appropriate amount of a fragrance containing a Japanese mint extract.

Example 5 Toothpaste With the composition shown in Table 5, a toothpaste (No. 16-18) was prepared according to a conventional method, and a liquid dentifrice (No. 19) was similarly prepared with the composition shown in Table 6.

  The above dentifrice also has excellent antibacterial properties and has an appropriate amount of a fragrance containing a Japanese mint extract, so that its flavor is also good.

It is a figure which shows the flowchart of the selection method of the oral product which concerns on this invention.

Explanation of symbols

1: Data input unit 2: Computer 3: Database 4: Data output unit

Claims (13)

An oral cavity comprising one or more antibacterial agents selected from the group consisting of cetylpyridinium chloride, chlorhexidine salt, hexetidine, decalinium chloride, benzalkonium chloride, and benzethonium chloride, and a Japanese mint extract Composition.   The composition for oral cavity according to claim 1, wherein the antibacterial agent is cetylpyridinium chloride and / or chlorhexidine salt.   And one or more active ingredients selected from the group consisting of vitamin E, vitamin E derivatives, glycyrrhizic acid, glycyrrhizinate, tranexamic acid, potassium nitrate, aluminum lactate, sodium fluoride, monofluorophosphate The composition for oral cavity of Claim 1 or 2 containing.   Furthermore, the composition for oral cavity in any one of Claims 1-3 containing a nonionic surfactant.   Furthermore, as a wetting agent, any one of Claims 1-4 containing 3 or more types of mixtures selected from the group which consists of glycerol, sorbitol, propylene glycol, ethylene glycol, 1, 3- butylene glycol, polyethylene glycol, polypropylene glycol. The composition for oral cavity according to 2.   It is a toothpaste, a liquid dentifrice, a liquid dentifrice, a mouthwash, or a mouth spray, The composition for oral cavity in any one of Claims 1-5.   The mouse spray according to claim 6, comprising 30% by mass or more of ethanol. A method of selecting an oral product suitable for treatment of a condition and / or symptoms in a subject's oral cavity, comprising:
Obtaining data on the condition and / or symptoms in the oral cavity of the subject and inputting the data to a computer;
A step of selecting one or more oral products suitable for treatment of a condition and / or symptoms in the oral cavity of a subject from a database by a computer and outputting the selected oral products (hereinafter, “output step”) )
A method for selecting an oral product, comprising: A method of selecting an oral product suitable for treatment of a condition and / or symptoms in a subject's oral cavity, comprising:
Obtaining one or more types of data suitable for the treatment of conditions and / or symptoms in the oral cavity of the subject, and obtaining data on the subject's oral conditions and / or symptoms and recording the data in a data sheet; A step of selecting an oral product from a database in accordance with the data recorded in the data sheet (hereinafter referred to as “selection step”),
A method for selecting an oral product, comprising: The database has data on oral conditions and / or symptoms, ingredients suitable for its treatment, and the composition of the oral composition;
The method for selecting an oral product according to claim 8 or 9, wherein the oral composition selected as suitable for treatment of an intraoral condition and / or symptom is output or selected. The database further includes data on the dosage form, usage, usage and / or precautions of oral compositions suitable for treatment of oral conditions and / or symptoms;
11. The oral cavity according to claim 10, wherein in the output step or selection step, one or more data relating to the dosage form, usage, usage amount and / or usage precautions are output or selected together with the selected oral product. Product selection method. The database further comprises data on oral appliances suitable for treatment of oral conditions and / or symptoms, their specifications, usage and / or precautions for use;
The oral product according to any one of claims 8 to 11, wherein in the output step or the selection step, one or more data relating to an oral appliance, its specification, usage and / or usage precautions are output or selected. Selection method.   The subject's oral condition and / or symptom data is obtained from interviews, occult blood tests, bacterial tests, biochemical mediator tests, biomarker tests, X-ray tests, dental clinical parameters, plaque clinical parameters, and periodontal disease. The method for selecting an oral product according to any one of claims 8 to 12, obtained by one or more means selected from the group consisting of clinical indicators.

Images