CN105521164A - Chinese eaglewood oral spraying agent and preparation method thereof - Google Patents
Chinese eaglewood oral spraying agent and preparation method thereof Download PDFInfo
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- CN105521164A CN105521164A CN201511027774.4A CN201511027774A CN105521164A CN 105521164 A CN105521164 A CN 105521164A CN 201511027774 A CN201511027774 A CN 201511027774A CN 105521164 A CN105521164 A CN 105521164A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention discloses a Chinese eaglewood oral spraying agent including the following substances: 7-10% of sorbitol, 3-5% of propylene glycol, 1-3% of PEG-50 hydrogenated castor oil, 0.05-0.2% of menthol, 1-3% of xylitol, 0.1-0.2% of sodium benzoate and balance of a Chinese eaglewood extract. The Chinese eaglewood oral spraying agent is added with the Chinese eaglewood extract, so that the Chinese eaglewood oral spraying agent has the effects of anesthetization, relieving pains, muscular relaxation, calming, relieving asthma, lowering blood pressure, resisting arrhythmia and resisting myocardial ischemia, the effects are not seen in oral sprays in prior art, and the Chinese eaglewood oral spraying agent also has the significant cough-relieving effects on dry cough caused by pharyngitis, colds and upper respiratory tract infection, and is easy to use and simple to make.
Description
Technical field
The present invention and Lignum Aquilariae Resinatum field, particularly a kind of Lignum Aquilariae Resinatum mouth sprays and preparation method thereof.
Background technology
In recent years, there is the phenomenon of halitosis in increasing people, halitosis can make people closely associate with people thus to produce inferiority complex, the orthobiosis and the social communication that have a strong impact on people affect self mood: the secretory function of halitosis on human hypothalamic hypophysis has out and out impact, nervous system is also had a direct impact, even can affect judgement.Affect self appetite: although somebody is insensitive to the halitosis of self, among it is really unconscious, have impact on appetite and gustatory glands.Market there is the mouth sprays of many types, but but lack a kind of Lignum Aquilariae Resinatum mouth spray spray, cause failing occurring the mouth spray spray of a kind of pressure of releiving, sleeping anti-strongly fragrant, conditioning body and mind.
Summary of the invention
The present invention is for solving the problems of the technologies described above as providing a kind of pressure of releiving, sleeping anti-strongly fragrant Lignum Aquilariae Resinatum mouth sprays.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of Lignum Aquilariae Resinatum mouth sprays, comprise following material, be 7-10% Sorbitol, 3-5% propylene glycol, 1-3%PEG-50 castor oil hydrogenated, 0.05-0.2% menthol, 1-3% xylitol, 0.1-0.2% sodium benzoate by percentage composition, all the other are Lignum Aquilariae Resinatum extract.
Beneficial effect of the present invention is: by adding Lignum Aquilariae Resinatum extract in mouth sprays, thus make the effect that mouth sprays has anesthesia, pain relieving, flesh pine, calmness, Zhichuan, blood pressure lowering, arrhythmia and resists myocardial ischemia, do not occur at original mouth sprays, also there is effect that the dry cough obviously caused pharyngitis, flu, upper respiratory tract infection has significant antitussive cough-relieving, easy to use, make simple.
As a kind of preferred structure of the present invention, in order to the problem that the content improving Lignum Aquilariae Resinatum extract is inadequate, the percentage composition of described Lignum Aquilariae Resinatum extract is 80-87.85%.So, by the Lignum Aquilariae Resinatum extract of 80-87.85%, strengthen the effect of Lignum Aquilariae Resinatum, the effect of Lignum Aquilariae Resinatum is embodied further.
As a kind of preferred structure of the present invention, in order to improve the indefinite problem of Lignum Aquilariae Resinatum extract composition, described Lignum Aquilariae Resinatum extract comprises baimuxinic acid, baimuxinal, Lignum Aquilariae Resinatum spiral alcohol, baimuxinol, benzylacetone, furan baimuxinal, Ainenofuranol.So, the composition of further clear and definite Lignum Aquilariae Resinatum extract, provides foundation for making Lignum Aquilariae Resinatum extract.
As a kind of preferred structure of the present invention, in order to improve the problem that Lignum Aquilariae Resinatum extract cannot obtain, described Lignum Aquilariae Resinatum extract is obtained by following steps,
Extract the timber being rich in Lignum Aquilariae Resinatum oils and fats;
Removing is not containing Rhizoma Atractylodis macrocephalae's part of Lignum Aquilariae Resinatum;
Dry in the shade, pulverize with physical pulverization machine and obtain Lignum Aquilariae Resinatum superfines;
Add water and put into supersonic wave wall breaking pulverizer, carry out vibration and pulverize, allow fat-soluble Lignum Aquilariae Resinatum component dissolves in water, make it to produce emulsion, thus obtain ultra tiny Lignum Aquilariae Resinatum extract.
So, effectively can obtain Lignum Aquilariae Resinatum extract by above-mentioned steps, make processing technology definitely, make Lignum Aquilariae Resinatum extract be more prone to be dissolved in the middle of mouth sprays.
As a kind of preferred structure of the present invention, in order to improve the bad problem of Lignum Aquilariae Resinatum mouth sprays mouthfeel effect, the pH value of described Lignum Aquilariae Resinatum mouth sprays is 6-7.So, by the pH value of clear and definite Lignum Aquilariae Resinatum mouth sprays, make Lignum Aquilariae Resinatum mouth sprays mouthfeel good effective, more meet food sanitation standard.
For solving the problems of the technologies described above, present invention also offers Lignum Aquilariae Resinatum mouth sprays preparation method, comprising the following steps:
Step one, menthol to be dissolved in propylene glycol completely;
Step 2, by dissolve after liquid in, add Lignum Aquilariae Resinatum extract, sorbitol, PEG-50 castor oil hydrogenated, xylitol successively, be stirred to and mix completely;
Step 3, add sodium benzoate by mixed liquid, stir to the stable liquid becoming transparent and homogeneous;
Step 4, stable liquid is at room temperature placed into cooling, survey its pH value, if pH value is between 6-7, then fill is in spraying bottle, makes finished product.
Beneficial effect of the present invention is: by adding Lignum Aquilariae Resinatum extract in mouth sprays, thus make the effect that mouth sprays has anesthesia, pain relieving, flesh pine, calmness, Zhichuan, blood pressure lowering, arrhythmia and resists myocardial ischemia, do not occur at original mouth sprays, also there is effect that the dry cough obviously caused pharyngitis, flu, upper respiratory tract infection has significant antitussive cough-relieving, easy to use, make simple.
As a kind of preferred structure of the present invention, in order to improve the uncertain problem of mouth sprays composition, also comprised before described step one:
Get the Lignum Aquilariae Resinatum extract that mass parts is respectively the Sorbitol of 7-10 part, the propylene glycol of 3-5 part, the PEG-50 castor oil hydrogenated of 1-3 part, the menthol of 0.05-0.2 part, the xylitol of 1-3 part, the sodium benzoate of 0.1-0.2 part and 78.6-87.85 part, for subsequent use.So, the composition of mouth sprays can being specified, providing foundation for making Lignum Aquilariae Resinatum mouth sprays.
As a kind of preferred structure of the present invention, in order to improve the problem that cannot make Lignum Aquilariae Resinatum extract, also comprised before described step one:
Timber containing resin is made Lignum Aquilariae Resinatum extract, Lignum Aquilariae Resinatum extract is clayed into power, for subsequent use.So, effectively can obtain Lignum Aquilariae Resinatum extract by above-mentioned steps, make processing technology definitely, make Lignum Aquilariae Resinatum extract be more prone to be dissolved in the middle of mouth sprays.
Detailed description of the invention
By describing technology contents of the present invention, structural feature in detail, being realized object and effect, be explained in detail below in conjunction with embodiment.
Lignum Aquilariae Resinatum mouth sprays of the present invention, comprise following material, be 7-10% Sorbitol, 3-5% propylene glycol, 1-3%PEG-50 castor oil hydrogenated, 0.05-0.2% menthol, 1-3% xylitol, 0.1-0.2% sodium benzoate by percentage composition, all the other are Lignum Aquilariae Resinatum extract.Lignum Aquilariae Resinatum has anesthesia, pain relieving, Muscle relaxation, still has calmness, anti-asthmatic action, hypotensive effect, arrhythmia and function of resisting myocardial ischemia, and Lignum Aquilariae Resinatum also has obvious antitumaous effect.Lignum Aquilariae Resinatum is avoided and sees fire, raw mill use, QI stagnated by cold, can with the Radix Linderae, the Radix Aucklandiae, Semen Arecae compatibility, with circulation of qi promoting warming middle-JIAO to relieve pain.All insufficiency of kidney-YANG, decline of the fire from the gate of life, umbilicus abdomen cold type of pain, soreness of the waist and knees, sexual impotence cold sperm person, all can use.The percentage composition of Lignum Aquilariae Resinatum extract is 80-87.85%.So, by the Lignum Aquilariae Resinatum extract of 80-87.85%, strengthen the effect of Lignum Aquilariae Resinatum, the effect of Lignum Aquilariae Resinatum is embodied further.Lignum Aquilariae Resinatum extract comprises baimuxinic acid, baimuxinal, Lignum Aquilariae Resinatum spiral alcohol, baimuxinol, benzylacetone, furan baimuxinal, Ainenofuranol.So, the composition of further clear and definite Lignum Aquilariae Resinatum extract, provides foundation for making Lignum Aquilariae Resinatum extract.Lignum Aquilariae Resinatum extract is obtained by following steps: S1, extract the timber being rich in Lignum Aquilariae Resinatum oils and fats; S2, removing be not containing Rhizoma Atractylodis macrocephalae's part of Lignum Aquilariae Resinatum; S3, to dry in the shade, pulverize with physical pulverization machine and obtain Lignum Aquilariae Resinatum superfines; S4, add water and put into supersonic wave wall breaking pulverizer, carry out vibration and pulverize, allow fat-soluble Lignum Aquilariae Resinatum component dissolves in water, make it to produce emulsion, thus obtain ultra tiny Lignum Aquilariae Resinatum extract.So, effectively can obtain Lignum Aquilariae Resinatum extract by above-mentioned steps, make processing technology definitely, make Lignum Aquilariae Resinatum extract be more prone to be dissolved in the middle of mouth sprays.
In the present embodiment, the practical operation of Lignum Aquilariae Resinatum is: the large tree selecting trunk diameter more than 30 centimetres, apart from the trunk at 1 ~ 2 meter of, ground, with cutter along cutting several cutter, deeply about 3 ~ 4 centimetres, treating its secretion resin, after the several years, can extract Lignum Aquilariae Resinatum.The new wound caused when extracting, still can continue to generate Lignum Aquilariae Resinatum.On the trunk at distance about 1 meter of, ground, dark 3 ~ 6 centimetres can also be cut a hole into, several osculums (being commonly called as " opening fragrant door ") that diameter is about 3 ~ 10 centimetres, then seal with earth, treat the xylem secretion resin near wound, generate Lignum Aquilariae Resinatum after the several years, can extract.The Isolated From Thymelaeaceae Species such as Rhizoma Atractylodis macrocephalae's XIANGSHU withered again, sweet XIANGSHU, eagle ebon, also can find natural agilawood sometimes, this perfume (or spice) because of the age comparatively of a specified duration, fat content is high, and quality is better, but output is few.Come after Lignum Aquilariae Resinatum, then reject not resiniferous part with pocket knife, after drying, be finished product.Must be stored in airtight container, put shady and cool dry place, prevent from going rancid, drying up.So, effectively can obtain Lignum Aquilariae Resinatum extract by above-mentioned steps, make processing technology definitely, make Lignum Aquilariae Resinatum extract be more prone to be dissolved in the middle of mouth sprays.The pH value of Lignum Aquilariae Resinatum mouth sprays is 6-7.So, by the pH value of clear and definite Lignum Aquilariae Resinatum mouth sprays, make Lignum Aquilariae Resinatum mouth sprays mouthfeel good effective, more meet food sanitation standard.
Embodiment of the present invention additionally provides a kind of Lignum Aquilariae Resinatum mouth sprays preparation method, comprises the following steps:
Step one, menthol to be dissolved in propylene glycol completely;
Step 2, by dissolve after liquid in, add Lignum Aquilariae Resinatum extract, sorbitol, PEG-50 castor oil hydrogenated, xylitol successively, be stirred to and mix completely;
Step 3, add sodium benzoate by mixed liquid, stir to the stable liquid becoming transparent and homogeneous;
Step 4, stable liquid is at room temperature placed into cooling, survey its pH value, if pH value is between 6-7, then fill is in spraying bottle, makes finished product.
Also comprised before described step one:
Get the Lignum Aquilariae Resinatum extract that mass parts is respectively the Sorbitol of 7-10 part, the propylene glycol of 3-5 part, the PEG-50 castor oil hydrogenated of 1-3 part, the menthol of 0.05-0.2 part, the xylitol of 1-3 part, the sodium benzoate of 0.1-0.2 part and 78.6-87.85 part, for subsequent use.So, the composition of mouth sprays can being specified, providing foundation for making Lignum Aquilariae Resinatum mouth sprays.
Also comprised before described step one:
Timber containing resin is made Lignum Aquilariae Resinatum extract, Lignum Aquilariae Resinatum extract is clayed into power, for subsequent use.So, effectively can obtain Lignum Aquilariae Resinatum extract by above-mentioned steps, make processing technology definitely, make Lignum Aquilariae Resinatum extract be more prone to be dissolved in the middle of mouth sprays.
In use procedure, make mouth sprays by above-mentioned steps, when and where, can mouth sprays be used, can spray outward also can in spray, the feature of pressure of releiving, sleeping anti-strongly fragrant, conditioning body and mind can be played.The present invention by adding Lignum Aquilariae Resinatum extract in mouth sprays, thus make the effect that mouth sprays has anesthesia, pain relieving, flesh pine, calmness, Zhichuan, blood pressure lowering, arrhythmia and resists myocardial ischemia, do not occur at original mouth sprays, also there is effect that the dry cough obviously caused pharyngitis, flu, upper respiratory tract infection has significant antitussive cough-relieving, easy to use, make simple.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (8)
1. a Lignum Aquilariae Resinatum mouth sprays, it is characterized in that: comprise following material, be 7-10% Sorbitol, 3-5% propylene glycol, 1-3%PEG-50 castor oil hydrogenated, 0.05-0.2% menthol, 1-3% xylitol, 0.1-0.2% sodium benzoate by percentage composition, all the other are Lignum Aquilariae Resinatum extract.
2. Lignum Aquilariae Resinatum mouth sprays according to claim 1, is characterized in that: the percentage composition of described Lignum Aquilariae Resinatum extract is 80-87.85%.
3. Lignum Aquilariae Resinatum mouth sprays according to claim 1, is characterized in that: described Lignum Aquilariae Resinatum extract comprises baimuxinic acid, baimuxinal, Lignum Aquilariae Resinatum spiral alcohol, baimuxinol, benzylacetone, furan baimuxinal, Ainenofuranol.
4. Lignum Aquilariae Resinatum mouth sprays according to claim 1, is characterized in that: described Lignum Aquilariae Resinatum extract is obtained by following steps,
Extract the timber being rich in Lignum Aquilariae Resinatum oils and fats;
Removing is not containing Rhizoma Atractylodis macrocephalae's part of Lignum Aquilariae Resinatum;
Dry in the shade, pulverize with physical pulverization machine and obtain Lignum Aquilariae Resinatum superfines;
Add water and put into supersonic wave wall breaking pulverizer, carry out vibration and pulverize, allow fat-soluble Lignum Aquilariae Resinatum component dissolves in water, make it to produce emulsion, thus obtain ultra tiny Lignum Aquilariae Resinatum extract.
5. Lignum Aquilariae Resinatum mouth sprays according to claim 1, is characterized in that: the pH value of described Lignum Aquilariae Resinatum mouth sprays is 6-7.
6. a Lignum Aquilariae Resinatum mouth sprays preparation method, is characterized in that, comprises the following steps:
Step one, menthol to be dissolved in propylene glycol completely;
Step 2, by dissolve after liquid in, add Lignum Aquilariae Resinatum extract, sorbitol, PEG-50 castor oil hydrogenated, xylitol successively, be stirred to and mix completely;
Step 3, add sodium benzoate by mixed liquid, stir to the stable liquid becoming transparent and homogeneous;
Step 4, stable liquid is at room temperature placed into cooling, survey its pH value, if pH value is between 6-7, then fill is in spraying bottle, makes finished product.
7. Lignum Aquilariae Resinatum mouth sprays preparation method according to claim 6, is characterized in that, also comprised before described step one:
Get the Lignum Aquilariae Resinatum extract that mass parts is respectively the Sorbitol of 7-10 part, the propylene glycol of 3-5 part, the PEG-50 castor oil hydrogenated of 1-3 part, the menthol of 0.05-0.2 part, the xylitol of 1-3 part, the sodium benzoate of 0.1-0.2 part and 78.6-87.85 part, for subsequent use.
8. Lignum Aquilariae Resinatum mouth sprays preparation method according to claim 6, is characterized in that, also comprised before described step one:
Timber containing resin is made Lignum Aquilariae Resinatum extract, Lignum Aquilariae Resinatum extract is clayed into power, for subsequent use.
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| CN201511027774.4A CN105521164A (en) | 2015-12-31 | 2015-12-31 | Chinese eaglewood oral spraying agent and preparation method thereof |
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Cited By (4)
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| CN108542976A (en) * | 2018-07-12 | 2018-09-18 | 草本搭档有限公司 | A kind of agalloch eaglewood spray formula and preparation method thereof |
| CN110693834A (en) * | 2019-10-24 | 2020-01-17 | 大连怡爽口腔医疗科技有限公司 | Oral moistening spray |
| CN110721241A (en) * | 2019-12-12 | 2020-01-24 | 李志俊 | Medicine for treating chronic pharyngitis and preparation method thereof |
| CN111437240A (en) * | 2020-04-30 | 2020-07-24 | 云南风联科技有限公司 | Plant agilawood-flavor oral cavity atomized liquid and preparation method thereof |
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| CN108542976A (en) * | 2018-07-12 | 2018-09-18 | 草本搭档有限公司 | A kind of agalloch eaglewood spray formula and preparation method thereof |
| CN110693834A (en) * | 2019-10-24 | 2020-01-17 | 大连怡爽口腔医疗科技有限公司 | Oral moistening spray |
| CN110721241A (en) * | 2019-12-12 | 2020-01-24 | 李志俊 | Medicine for treating chronic pharyngitis and preparation method thereof |
| CN111437240A (en) * | 2020-04-30 | 2020-07-24 | 云南风联科技有限公司 | Plant agilawood-flavor oral cavity atomized liquid and preparation method thereof |
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