CN110721241A

CN110721241A - Medicine for treating chronic pharyngitis and preparation method thereof

Info

Publication number: CN110721241A
Application number: CN201911277193.4A
Authority: CN
Inventors: 李志俊
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-12
Filing date: 2019-12-12
Publication date: 2020-01-24

Abstract

The invention provides a medicine for treating chronic pharyngitis, which is an extract obtained by soaking Chinese medicine agilawood in 45-60 vol% edible alcohol. The extract is used as a raw material, and is prepared into various oral preparations or buccal tablets according to the conventional process and auxiliary materials of pharmacy. The preparation method of the leaching solution comprises the following steps: mixing Chinese medicine lignum Aquilariae Resinatum with edible alcohol at a weight ratio of 3-10:100, soaking in edible alcohol at room temperature under sealed condition for 5-10 days, and filtering to obtain filtrate to obtain product extract. The medicine can achieve the effect of curing chronic pharyngitis, has high cure rate, and is not easy to relapse after being cured; the medicinal components are taken from natural Chinese herbal medicines, so that the toxic and side effects are small; the raw materials are easy to obtain, and the preparation is simple.

Description

Medicine for treating chronic pharyngitis and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for treating chronic pharyngitis and a preparation method thereof.

Background

Chronic pharyngitis is a common frequently-occurring disease, is a diffuse chronic inflammation of pharyngeal mucosa, submucosa and lymphoid tissue, is a part of chronic inflammation of upper respiratory tract, and is often seen in adults. The disease has long course of disease, stubborn symptoms and difficult cure. The causes of the disease are mainly: 1. recurrent attacks of acute pharyngitis, the main cause; 2. chronic rhinitis, sinusitis, etc. can also be caused by long-term nasal obstruction, mouth breathing, nasal discharge, throat irritation, chronic tonsillitis, periodontitis, etc.; 3. excessive smoking and drinking for a long time, dust, harmful gas stimulation, overeating stimulating food and the like; 4. occupational factors such as teachers, announcers, etc., excessive speaking and voice consumption; 5. systemic factors such as anemia, chronic bronchitis, bronchial asthma, endocrine disturbance and the like cause the disease secondarily.

Clinically, the disease has no obvious general symptoms, and is mainly manifested by various uncomfortable sensations in the pharynx, such as foreign body sensation, dryness, burning sensation, itching, slight pain, and the like. The sticky and thick secretions often adhere to the back wall of the pharynx, and frequent irritating dry cough with nausea and even bloody secretions can appear in the morning. The secretion is increased and sticky, so it is usually a throat clearing action. At present, no effective treatment means for the disease is available in medicine. The existing treatment methods are summarized mainly as follows: 1. for the reasons, the treatment mainly comprises the steps of keeping on outdoor activities, giving up smoking, giving up drinking and other bad hobbies, keeping indoor air fresh, and actively treating rhinitis, tracheobronchitis and other chronic respiratory inflammations and the like; 2. the traditional Chinese medicine is used for treating the diseases, and the commonly used Chinese patent medicines comprise pills of six ingredients with rehmannia, pills of medlar, chrysanthemum and rehmannia, capsules of ginseng and wheat, certain traditional Chinese medicine buccal tablets and the like; the commonly used single proved recipe mainly comprises boat-fruited sterculia seed, honeysuckle flower, chrysanthemum flower, dwarf lilyturf tuber, liquorice root and the like which are brewed by boiled water and drunk as tea; 3. the topical treatment mainly comprises gargling with compound borax solution, and smearing throat with 5% silver nitrate or 2% iodine glycerol.

The above methods generally only achieve the effect of relieving symptoms, and are difficult to cure, and although there are cases of cure, the overall cure rate is still not high.

Disclosure of Invention

The invention aims to provide a medicine capable of effectively treating chronic pharyngitis, aiming at the problems in the prior art.

Therefore, the invention adopts the following technical scheme:

a medicine for treating chronic pharyngitis is prepared by soaking lignum Aquilariae Resinatum in 45-60% vol edible alcohol to obtain extractive solution.

Furthermore, the extract is used as a raw material to prepare various oral preparations or buccal tablets according to the conventional process and auxiliary materials of pharmacy.

Further, the oral preparation comprises tablets, pills, capsules or oral liquid.

Further, the edible alcohol is white spirit.

The preparation method of the medicine for treating chronic pharyngitis comprises the following steps:

mixing Chinese medicine lignum Aquilariae Resinatum with edible alcohol at a weight ratio of 3-10:100, soaking in edible alcohol at room temperature under sealed condition for 5-10 days, and filtering to obtain filtrate to obtain product extract.

Further, before soaking, the agilawood is crushed into 0.3-0.6cm fragments, so as to be beneficial to leaching out the active ingredients of the agilawood.

The quality standard of the raw material agilawood medicinal material is required to meet the record of agilawood in the 2015 edition of Chinese pharmacopoeia. The source is a resin-containing wood derived from Gilg of Aquilaria sinensis (Lour.) of the Thymelaeaceae family.

Chen Xiang is pungent and bitter in flavor and slightly warm in nature. Move qi and alleviate pain, warm middle energizer and arrest vomiting, receive qi and relieve dyspnea. The bibliography: treat wind-damp-toxicity swelling and remove bad breath. "(materia Medica of sea medicine): "governing heart and abdominal pain, cholera, nausea and vomiting, refreshing mind; it is used in plaster for treating sores and swelling. "

The clinical treatment difficulty of the chronic pharyngitis is more difficult than that of the acute pharyngitis, the course of disease is long, the chronic pharyngitis is not easy to cure, and no better treatment method exists in the traditional Chinese medicine and the western medicine at present. According to the traditional Chinese medicine theory, the disease is equivalent to slow throat impediment, deficiency fire throat impediment and yang deficiency throat impediment. As for the pathogenesis of the disease, the current traditional Chinese medicine theory generally holds that the disease is caused by viscera deficiency, throat malnutrition, phlegm coagulation and blood stasis and the like. According to the ancestral treatment method and clinical medication practice, the inventor thinks that the pathogenesis of the disease is mainly caused by qi disorder and deficiency and cold of lower elements. Because the efficacy of Chenxiang is characterized by pungent and warm property entering kidney meridian, it can warm kidney and receive qi, move qi and alleviate pain, and it is good at treating qi stagnation syndrome and deficiency-cold syndrome of lower origin, so it is used singly. Because the traditional usage of the agilawood is decoction in water and then administration is carried out, the dosage is generally 1-5g, the effective ingredients are not easy to dissolve out under the drug administration method, and the drug effect cannot be fully exerted, the treatment is carried out by using edible alcohol or white spirit leachate. In order to ensure the safety of medication, the treatment dosage of the method is far lower than the traditional Chinese medicine dosage of agilawood.

Modern medical research shows that the agilawood contains benzyl acetone, so that the agilawood has an effective cough relieving effect, and experiments also show that the linalool extract can promote the in-vitro guinea pig trachea antihistamine effect, so that the cough relieving effect is achieved. In addition, the agilawood extract also has anti-inflammatory and antibacterial effects, and has obvious inhibitory effect on bacillus bonder, typhoid bacillus, staphylococcus aureus and the like (huhuoxepin, sunhui, zhanyunfeng and the like, pharmacological action and quality control research progress of traditional Chinese medicine agilawood [ J ] evaluation and analysis of medication in hospitals in China, 2018,18 (2)).

However, the Chinese medicine for treating chronic pharyngitis, or the symptoms of chronic pharyngitis, deficiency fire pharyngitis, yang deficiency pharyngitis and the like which are called by Chinese medicine, has no report in traditional Chinese medicine literature and modern medical research data.

In conclusion, the beneficial effects of the invention are as follows: provides a new medicament for treating chronic pharyngitis, can achieve the effect of healing, has higher healing rate and is not easy to relapse after healing; the medicinal components are taken from natural Chinese herbal medicines, so that the toxic and side effects are small; the raw materials are easy to obtain, and the preparation is simple.

Detailed Description

The present invention will be further described with reference to the following specific examples.

Example 1: stock solution of alcohol leaching

Preparation: proportioning Chinese medicine agilawood and 45% (vol) edible alcohol according to the weight ratio of 3:100, then crushing the agilawood into 0.3-0.6cm fragments, putting the agilawood fragments into the edible alcohol, hermetically soaking for 5-10 days at normal temperature, and filtering to obtain filtrate, namely the product medicine.

The use method comprises the following steps: 10ml of the agilawood alcohol extract prepared by the method is taken for direct drinking twice a day. The composition is administered continuously for 7-14 days. When administered, the medicine is retained in oral cavity and pharynx as long as possible.

Example 2: tablet formulation

Preparation: the Chinese medicine agilawood tablet is prepared by mixing Chinese medicine agilawood and 60% (vol) edible alcohol according to the weight ratio of 4:100, then preparing a leaching stock solution according to the method of the embodiment 1, taking the stock solution as a raw material, adding auxiliary materials according to the conventional preparation process of Chinese medicine tablets, and drying and tabletting.

The use method comprises the following steps: the dosage of the extract is 10ml per time, calculated according to the effective components, and the extract is taken twice a day. The composition is administered continuously for 7-14 days. When administered, the medicine is retained in oral cavity and pharynx as long as possible.

Example 3: pill preparation

Preparation: the Chinese medicine agilawood pill is prepared by proportioning Chinese medicine agilawood and 55% (vol) edible alcohol according to the weight ratio of 6:100, then preparing a leaching stock solution according to the method of the embodiment 1, taking the stock solution as a raw material, and adding auxiliary materials according to the conventional preparation process of Chinese medicine pills.

Example 4: capsule preparation

Preparation: the Chinese medicine agilawood capsule is prepared by mixing Chinese medicine agilawood and 60% (vol) edible alcohol according to the weight ratio of 3:100, then preparing a leaching stock solution according to the method of the embodiment 1, taking the stock solution as a raw material, adding auxiliary materials according to the conventional preparation process of Chinese medicine capsules, and drying.

The use method comprises the following steps: the dosage of the extract is 10ml per time, calculated according to the effective components, and the extract is taken twice a day. The composition is administered continuously for 7-14 days.

Example 5: oral liquid

Preparation: the Chinese medicine agilawood oral liquid is prepared by mixing Chinese medicine agilawood and 50% (vol) edible alcohol according to the weight ratio of 10:100, then preparing a leaching stock solution according to the method of the embodiment 1, taking the stock solution as a raw material, adding auxiliary materials according to the conventional preparation process of the Chinese medicine oral liquid, and concentrating.

Example 6: buccal tablet

Preparation: the Chinese medicine agilawood tablet is prepared by mixing Chinese medicine agilawood and 45% (vol) white spirit according to the weight ratio of 5:100, then preparing a leaching stock solution according to the method of the embodiment 1, taking the stock solution as a raw material, and adding auxiliary materials according to the conventional preparation process of Chinese medicine buccal tablets.

The use method comprises the following steps: the dosage of the extract is 10ml based on the effective components, and the extract is taken twice a day. It is administered continuously for 7-14 days.

Observation and statistics of curative effect:

the curative effect observation statistics is carried out on 61 chronic pharyngitis patients treated between years of 2015-2018 in the clinic of the applicant, wherein: 22 men and 39 women with age between 28-57 years. Order to take the agilawood alcohol extract obtained in the example 1 continuously for one week, the male patients can be cured by 14 patients, and 6 patients with obvious effect and effectiveness can be cured; the cure rate is 64 percent, the obvious effect and the effective rate are 27 percent, and the total effective rate is 91 percent. 27 female patients are cured, and 7 effective patients are cured; the cure rate is 69%, the significant effect and the effective rate are 18%, and the total effective rate is 87%.

Typical cases are:

somebody, a woman, in the age of 52 years, perceives the throat as dry and itchy for many years, and is diagnosed as chronic pharyngitis through hospitals. The Chinese eaglewood alcohol extract is taken for two weeks, the symptoms completely disappear, and the throat is dry and itchy.

When a certain old woman is aged 55 years old, the foreign body sensation of the pharynx is obvious, and the pharynx has symptoms of dryness and itching for many years, and the chronic pharyngitis is diagnosed by a hospital. The Chinese eaglewood alcohol extract is taken for two weeks, foreign body sensation symptoms are obviously relieved, and dry throat and itching feel disappear.

A certain old woman in 31 years old feels a remarkable foreign body sensation in the pharynx, is accompanied by symptoms such as excessive phlegm and frequent throat clearing actions for many years, and is diagnosed as chronic pharyngitis through hospital diagnosis. After the Chinese eaglewood alcohol extract is taken for a week, foreign body sensation in the pharynx is completely disappeared, and excessive phlegm symptoms are obviously relieved.

In Zhan Yi, male, 38 years old, has long-term smoking experience, conscious pharynx has obvious foreign body sensation and slight pain for many years, and frequent irritative dry cough and retching appear in the morning. The chronic pharyngitis is diagnosed by hospital diagnosis. After the Chinese eaglewood alcohol extract is taken for two weeks, foreign body sensation, slight pain sensation, dry cough, retching and other symptoms of the pharynx disappear, and after tracking and observation for 1 month, no relapse occurs.

Wang somebody, male, age 54, has a history of drinking. Foreign body sensation, dry sensation and itching sensation in pharynx can be sensed for a long time, and frequent irritant dry cough and throat clearing action appear in the morning. The chronic pharyngitis is diagnosed by hospital diagnosis and is more serious. The agilawood buccal tablet is used for treating two weeks, foreign body sensation of pharynx disappears, and symptoms such as dry sensation, itching sensation, dry cough, throat clearing and the like are obviously relieved.

Claims

1. A medicine for treating chronic pharyngitis is characterized in that the medicine is an extract obtained by soaking Chinese medicine agilawood in 45-60 vol% edible alcohol.

2. The medicine for treating chronic pharyngitis according to claim 1, wherein the medicine is various oral preparations or buccal tablets prepared from the extract as a raw material by using conventional pharmaceutical processes and auxiliary materials.

3. The medicine for treating chronic pharyngitis according to claim 2, wherein the oral preparation comprises tablet, pill, capsule or oral liquid.

4. The medicine for treating chronic pharyngitis according to claim 1, wherein the edible alcohol is white spirit.

5. A method for preparing a medicament for treating chronic pharyngitis according to claim 1, which comprises the steps of:

6. A process for preparing a medicine according to claim 5, wherein the lignum Aquilariae Resinatum is pulverized into 0.3-0.6cm pieces before soaking.