JP2011126818A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dentifrice composition that is obtained by stably mixing a dentifrice composition mixed with an extract of a plant selected from rosemary, sage, roots of Scutellaria baicalensis Georgi, carrot, peony, soapberry and Angelica acutiloba with water and/or an organic solvent with glycyrrhizic acid, its salt and glycyrrhetinic acid, has high anti-inflammatory effect, improved bad taste derived from a crude drug, good foaming and excellent sense of use. <P>SOLUTION: The dentifrice composition is obtained by mixing a dentifrice composition mixed with an extract of a plant selected from rosemary, sage, roots of Scutellaria baicalensis Georgi, carrot, peony, soapberry and Angelica acutiloba with water and/or an organic solvent with (A) one or more selected from glycyrrhizic acid, its salt and glycyrrhetinic acid, (B) sodium chloride and (C) a polyoxyethylene hardened castor oil having an average addition mole number of ethylene oxide of 5-30 and has a mass ratio of the component (B)/the component (C) of 0.3-20. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a dentifrice composition containing an extract of plant and water and / or organic solvent selected from rosemary, sage, dragon, carrot, peony, mukuroji and toki. The present invention relates to a dentifrice composition that is improved in bad taste derived from the above, has excellent storage stability of glycyrrhizinate and glycyrrhetinic acid, has a high anti-inflammatory effect, and has a good feeling of use such as foaming.

  Conventionally, various components are blended in the dentifrice composition for the purpose of preventing problems in the oral cavity. For the purpose of preventing gingivitis, various components having an anti-inflammatory effect, a blood circulation promoting effect, a tissue activation effect and the like are used. Among them, herbal extracts such as rosemary, sage, oxon, carrot, peony, mugwort, and toki have anti-inflammatory action, blood circulation promoting action, astringent action, antibacterial action, moisturizing action, cleaning action, etc. It is known to mix | blend more with a composition for oral cavity (refer patent documents 1-5).

  On the other hand, glycyrrhizinate such as dipotassium glycyrrhizinate and glycyrrhetinic acid have a high anti-inflammatory effect, and are conventionally known to be blended into oral compositions (see Patent Documents 6 to 9).

  However, when glycyrrhizinate or glycyrrhetinic acid is added to the oral composition, there is a problem that the glycyrrhizinate or glycyrrhetinic acid is decomposed and the stability decreases with time. Applicants have so far formulated glycyrrhetinic acid and its derivatives and fragrances selected from origanum oil, thyme oil, capsicum extract and spirantol in oral compositions containing fragrances such as menthol, cineol and anethole. It has been proposed that a composition for oral cavity with good stability of the derivatives thereof and derivatives thereof can be obtained (see Patent Document 6). Moreover, when a fatty acid alkanolamide is added to an oral composition containing a water-soluble salt of glycyrrhetinic acid and / or a derivative thereof and a higher alkyl ester, decomposition of glycyrrhetinic acids is effectively suppressed, and stability of glycyrrhetinic acids is improved. It has been proposed that a good oral composition can be obtained (see Patent Document 7).

  Combined with herbal extracts such as rosemary, sage, oxon, carrot, peony, mukuroji, touki, etc., which have anti-inflammatory effects, and glycyrrhizic acid, its salts, and glycyrrhetinic acid, which have high anti-inflammatory effects, in oral compositions If so, a high anti-inflammatory effect can be expected. However, in this case, since the herbal extract is a component collected from a natural product, there is a problem that when blended in a dentifrice composition, the taste becomes bitter and the feeling of use becomes worse, and such a crude drug that is such a natural product. When the extract is used in combination with glycyrrhizic acid, its salt, and glycyrrhetinic acid, it is affected by impurities contained in the herbal extract or the extraction solvent, and glycyrrhizic acid, its salt, and glycyrrhetinic acid are easily degraded over time. Therefore, it is difficult to stably mix glycyrrhizinate and glycyrrhetinic acid with time, and these points are technical problems.

  The applicant has proposed a dentifrice composition in which the bitterness derived from tannin is suppressed, in which a herbal extract containing tannin such as rosemary extract and licorice extract are combined in Patent Document 10. The licorice extract is an extract obtained from the roots and rhizomes of the legumes, licorice (licorice), and the extract and powder contain glycyrrhizic acid, a sweetening ingredient. Thus, a tannin-containing dentifrice composition with improved bitterness derived from tannin in the herbal extract and improved usability can be obtained. Patent Document 10 describes a dentifrice composition in which Example 9 is blended with 0.2% by weight of rosemary extract, 0.02% by weight of licorice extract, and 0.05% by weight of dipotassium glycyrrhizinate. In Example 22, 0.05% by mass of glycyrrhetinic acid, 0.001% by mass of Toki extract, 0.1% by mass of rosemary extract, 0.1% by mass of sage extract, and 0.0% by weight of dried argonian extract. A dentifrice composition containing 1% by mass and 0.1% by mass of licorice extract is described. However, Patent Document 10 does not mention the storage stability of glycyrrhizinate or glycyrrhetinic acid, although the taste derived from the herbal extract is improved. In the compositions of Examples 9 and 22, sodium chloride and polyoxyethylene hydrogenated castor oil are not blended, so it is difficult to stably blend dipotassium glycyrrhizinate and glycyrrhetinic acid.

  Accordingly, in any technique, in a dentifrice composition in which a herbal extract selected from rosemary, sage, dragon, carrot, peony, mukuroji, touki and glycyrrhizic acid or a salt thereof or glycyrrhetinic acid is used in combination, glycyrrhizin It is difficult to obtain a dentifrice composition with a stable blend of acid or its salt and glycyrrhetinic acid over time, high anti-inflammatory effect, improved taste derived from herbal extracts, and excellent use feeling such as foaming there were,

JP 2000-297022 A JP 2000-20253 A JP 2003-81800 A JP 2005-289918 A JP 2006-306932 A Japanese Patent Laid-Open No. 61-152622 JP 62-155207 A JP 7-165545 A JP-A-8-40858 Japanese Patent Laid-Open No. 11-222419

  As described above, in a dentifrice composition containing a herbal extract, even if the herbal extract and glycyrrhizic acid and its salt or glycyrrhetinic acid are blended simultaneously, glycyrrhizic acid, its salt and glycyrrhetinic acid are stored over time. It is difficult to obtain a dentifrice composition having excellent stability, high anti-inflammatory effect, improved bad taste derived from these herbal extracts, and excellent foaming. Development is desired.

  The present invention has been made in response to such a demand, and a dentifrice composition containing an extract of water and / or organic solvent of a plant selected from rosemary, sage, dragon, carrot, peony, mukuroji, and touki, An object of the present invention is to provide the above-mentioned dentifrice composition that can stably contain glycyrrhizic acid and its salts and glycyrrhetinic acid, has high anti-inflammatory effect, has improved bad taste derived from herbal medicine, has good foaming, and has a good feeling of use. And

  As a result of intensive studies to achieve the above object, the present inventors formulated an extract of water and / or organic solvent of a plant selected from rosemary, sage, hornon, carrot, peony, mukuroji and toki. To the dentifrice composition, (A) one or more selected from glycyrrhizic acid and salts thereof, glycyrrhetinic acid, (B) sodium chloride, and (C) polyoxyethylene having an average added mole number of ethylene oxide of 5 to 30 When blended with hardened castor oil and the blending ratio of component (B) / component (C) is 0.3 to 20 by mass ratio, it is excellent in aging stability of glycyrrhizic acid and its salts and glycyrrhetinic acid. The present inventors have found that a dentifrice composition having a high anti-inflammatory effect, improved bad taste derived from the above-mentioned herbal medicine, and excellent foaming feeling can be obtained.

  In the present invention, when blending glycyrrhizic acid and its salt and glycyrrhetinic acid into the dentifrice composition blended with the above-mentioned specific plant extract, sodium chloride and a specific polyoxyethylene hydrogenated castor oil are blended appropriately in combination. Thus, sodium chloride improves the taste such as bitterness derived from a plant (herbal medicine) extract, and the mode of action is due to an appropriate salt concentration and a specific nonionic surfactant present in the composition. Although unknown, by increasing the solubilization amount of oil-soluble components in the composition, the degradation of glycyrrhizic acid and its salts and glycyrrhetinic acid over time is suppressed, and the storage stability of glycyrrhizic acid and its salts and glycyrrhetinic acid In combination with the above herbal extract, which is a natural product, glycyrrhizic acid and its salts and glycyrrhetinic acid In stably be formulated, high anti-inflammatory effects, foaming may be considered that it is possible to obtain the above excellent characteristics combines the dentifrice composition. Glycyrrhizic acid and its salt, glycyrrhetinic acid, sodium chloride, polyoxyethylene hydrogenated castor oil are known ingredients for dentifrice composition, but glycyrrhizic acid, its salt and glycyrrhetinic acid are used in combination with the above herbal extracts It is a new finding of the present inventors that the problem in this case can be solved by combining sodium chloride and polyoxyethylene hydrogenated castor oil.

Accordingly, the present invention provides the following dentifrice composition.
Claim 1:
Toothpaste composition formulated with water and / or organic solvent extract of plant selected from rosemary, sage, oxon, carrot, peony, mukuroji, touki, selected from (A) glycyrrhizic acid and its salt, glycyrrhetinic acid 1 or more, (B) sodium chloride, and (C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 5 to 30, and (B) component / (C) component mass ratio The dentifrice composition characterized by having 0.3 to 20.
Claim 2:
The dentifrice composition of Claim 1 which mix | blended 0.01-0.5 mass% of (A) component, 0.5-15 mass% of (B) component, and 0.3-3 mass% of (C) component. object.

  According to the present invention, in the dentifrice composition containing the herbal extract, the bad taste derived from the herbal extract is improved, and glycyrrhizic acid, its salt and glycyrrhetinic acid, which are one of the active ingredients, are stabilized. Can be blended in the composition, has excellent storage stability, has a high anti-inflammatory effect, has a good foaming feeling, and can be effectively used to prevent oral diseases such as periodontal disease.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention contains an extract of water and / or an organic solvent of a plant selected from rosemary, sage, oxon, carrot, peony, mukuroji and toki. And (A) one or more selected from glycyrrhizic acid and salts thereof, glycyrrhetinic acid, (B) sodium chloride, (C) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 5 to 30 It is a thing.

  The herbal medicine extract blended in the dentifrice composition of the present invention is an extract of plant and water and / or organic solvent selected from rosemary, sage, dragonfly, carrot, peony, mukuroji, and touki. May be used alone or in combination of two or more. Such herbal extracts are widely used for pharmaceuticals, cosmetics, foods, sundries and the like, and are commercially available in liquid or powder form. In the present invention, commercially available products can be used.

  The rosemary extract is prepared from leaves of mannen wax, or leaves and flowers, water, ethanol, propylene glycol, 1,3-butylene glycol, a mixed solution thereof, a 1% by weight urea-containing ethanol solution, or 1% by weight urea-containing 1, An extract obtained by extraction with a 3-butylene glycol solution, or an essential oil obtained by steam distillation from fresh leaves, branches, flowers, etc. of mannerou, especially as an extract to be blended in a dentifrice composition What extracted with water, ethanol, or these liquid mixture is preferable. As the rosemary extract, a commercially available product can be used, for example, rosemary extract-J (Maruzen Pharmaceutical Co., Ltd.) and the like.

  The sage extract is obtained from sage flowers, leaves or whole plants, water, ethanol, propylene glycol, 1,3-butylene glycol, a mixture thereof, a 1% by weight urea-containing ethanol solution or a 1% by weight urea-containing 1, An extract obtained by extraction with a 3-butylene glycol solution or an essential oil obtained by steam distillation from a sage leaf, and as an extract to be blended in a dentifrice composition, in particular, water, ethanol, or these What was extracted with the liquid mixture is preferable. In addition, since sage is closely related to salvia, a sage extract obtained by extracting from a leaf of a Labiatae salvia can be used. A commercial item can be used for a sage extract, for example, a salvia extract (Maruzen Pharmaceutical Co., Ltd.) etc. are mentioned.

  Ogon extract is extracted from the roots excluding perennial herb periwinkle planted in northern Siberia and the Korean peninsula from northern China with water, ethanol, absolute ethanol, 1,3-butylene glycol, or a mixture of these. As the extract to be obtained and mixed with the dentifrice composition, those extracted with water, ethanol, or a mixture thereof are particularly preferable. A commercially available product can be used as the ougon extract, and examples thereof include ougon extract-J (Maruzen Pharmaceutical Co., Ltd.).

  The carrot extract is obtained by extracting the root of ginseng root or the root dried root with ethanol, propylene glycol, 1,3-butylene glycol, a mixture thereof, or absolute ethanol, and is used for dentifrice. As the extract blended in the agent composition, those extracted with water, ethanol, or a mixture thereof are preferable. The carrot extract can use a commercial item, for example, a carrot extract (Maruzen Pharmaceutical Co., Ltd.) etc. are mentioned.

  The peonies extract is obtained by extraction from the roots of peonies or other closely related plants with water, ethanol, 1,3-butylene glycol, or a mixture thereof, and is an extract that is blended into the dentifrice composition As for, what was extracted with water, ethanol, or these liquid mixture is preferable. Commercially available products can be used as the peonies extract, and examples thereof include peonies extract-J (Maruzen Pharmaceutical Co., Ltd.).

  Mukuroji extract is obtained by extraction from the peel of mukuroji or other related plants with water, ethanol, 1,3-butylene glycol, or a mixture thereof, and as an extract to be blended into a dentifrice composition Is preferably extracted with water, ethanol, or a mixture thereof. A commercially available product can be used as the extract of mukuroji, and examples thereof include mukuroji extract powder (Maruzen Pharmaceutical Co., Ltd.).

  The touki extract is obtained by extracting from the roots of toki or other related plants (umbelliferae) with water, ethanol, propylene glycol, 1,3-butylene glycol, or a mixture thereof, and a dentifrice composition As the extract to be blended with, an extract extracted with water, ethanol, or a mixture thereof is preferable. A commercial item can be used for a touki extract, for example, a touki extract-JC (Maruzen Pharmaceutical Co., Ltd.) etc. are mentioned.

  The compounding quantity of these plant extracts is 0.00001-0.02 mass% in conversion of extract amount, Preferably it is 0.00001-0.01 mass%. If it is less than 0.00001% by mass, the anti-inflammatory effect may not be exhibited, and if it exceeds 0.02% by mass, an unpleasant taste may appear.

  In the composition of the present invention, the component (A) is one or more selected from glycyrrhizic acid and its salts and glycyrrhetinic acid, and these are known as active ingredients contained in the licorice extract.

As the glycyrrhizinate, for example, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, etc. can be used. Among them, glycyrrhizic acid is preferred because of its ease of incorporation into a dentifrice composition. Dipotassium is most preferred. As dipotassium glycyrrhizinate, for example, those manufactured by Maruzen Pharmaceutical Co., Ltd. can be used.
As glycyrrhetinic acid, β-glycyrrhetinic acid can be used. As β-glycyrrhetinic acid, for example, one manufactured by Maruzen Pharmaceutical Co., Ltd. can be used.
As the component (A), dipotassium glycyrrhizinate and β-glycyrrhetinic acid are particularly preferable.

  The blending amount of the component (A) is 0.01 to 0.5% (mass%, the same applies hereinafter), particularly 0.02 with respect to the entire composition (hereinafter the same unless otherwise specified). ~ 0.1% is preferred. If it is less than 0.01%, the stability due to storage may be reduced or a sufficient anti-inflammatory effect may not be obtained. If it exceeds 0.5%, foaming may be deteriorated and the feeling in use may be inferior.

The component (B) sodium chloride is a component effective for improving the bitterness derived from the herbal extract and stabilizing the component (A), and those sold by Iki Shiogyo Co., Ltd. can be used.
The amount of sodium chloride is preferably 0.5 to 15%, more preferably 3.0 to 10%. If it is less than 0.5%, stability due to storage of glycyrrhizic acid and its salts and glycyrrhetinic acid may be reduced, and bitterness derived from herbal extracts may not be improved. If it exceeds 15%, sufficient foaming may occur. It may not be obtained, or the feeling of use may be worse, for example, it may be too salty.

(C) Polyoxyethylene hydrogenated castor oil has an average added mole number of ethylene oxide of 5 to 30 mol, preferably 10 to 20 mol. Less than 5 moles are generally not commercially available. Moreover, when it exceeds 30 mol, glycyrrhizic acid, its salt, and glycyrrhetic acid may not be stably blended.
As such polyoxyethylene hydrogenated castor oil, for example, HCO-5, HCO-10, HCO-20, HCO-30 from Nikko Chemicals Co., Ltd., HC-5, HC-7 from Nippon Emulsion Co., Ltd., HC-10, HC-20, HC-30, BLAUNON RCW-20 (polyoxyethylene 20 mol) manufactured by Aoki Oil & Fat Co., Ltd. can be used.

  The blending amount of the polyoxyethylene hydrogenated castor oil as component (C) is preferably 0.3 to 3%, and more preferably 0.5 to 2%. If it is less than 0.3%, sufficient foaming may not be obtained, and if it exceeds 3%, a problem may occur in terms of bitterness.

  In the present invention, the glycyrrhizinate and glycyrrhetinic acid are stably blended, the bitterness and salty taste at the time of dentifrice are improved, and the ratio of (B) component / (C) component is obtained by mass ratio. It is important that it is 0.3 to 20, preferably 2 to 10. If the component (B) / component (C) is less than 0.3, the bitterness derived from the herbal extract cannot be improved, or the storage stability of glycyrrhizic acid and its salts and glycyrrhetinic acid is reduced. On the other hand, if it exceeds 20, a bitter taste will occur or sufficient foaming will not be obtained, and a satisfactory feeling of use will not be obtained.

  The dentifrice composition of the present invention can be prepared by a conventional method as a dentifrice such as a toothpaste, a liquid dentifrice, a liquid dentifrice, and a toothpaste, especially a toothpaste, and the effects of the present invention can be obtained depending on the dosage form. In addition to the above essential components, the following known components can be arbitrarily blended as long as they are not impaired. For example, in the case of toothpaste, abrasives, thickeners, binders, surfactants other than the component (C), sweeteners, pigments, preservatives, perfumes, the above herbal extracts and various components other than the component (A) An active ingredient etc. can be mix | blended and these ingredients and water can be mixed and it can manufacture according to a conventional method.

As abrasives, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, phosphoric acid abrasives such as calcium pyrophosphate, water Aluminum oxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, magnesium triphosphate, zeolite, zirconium silicate, hydroxyapatite, fluoro Apatite, calcium deficient apatite, tricalcium phosphate, quaternary calcium phosphate, eighth calcium phosphate, synthetic resin-based abrasives, etc. are used, and one of these may be used alone or in combination of two or more. Can. Among these, silica-based abrasives, calcium carbonate-based abrasives, and calcium phosphate-based abrasives are preferably used from the viewpoint of usability such as a feeling of brushing.
The blending amount of the abrasive is usually 7 to 50%, generally 7 to 30% for the silica-based abrasive and 15 to 50% for the calcium carbonate-based abrasive or calcium phosphate-based abrasive.

  As the thickener, sugar alcohols such as glycerin, sorbit, propylene glycol, polyethylene glycol (PEG), xylitol, maltitol, lactitol, polyhydric alcohols such as 1,3-butylene glycol, polypropylene glycol, ethanol, modified ethanol, Examples thereof include sugar alcohol-reduced starch saccharified products, and one or more of these can be blended. A compounding quantity is 5.0 to 50% normally.

  As the binder, cellulose-based binders such as sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl ethyl cellulose, methyl cellulose, carrageenan, sodium alginate, xanthan gum, guar gum, cationized cellulose, montmorillonite, Examples include tragacanth gum, karaya gum, arabic gum, locust bean gum, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, carbopol, silica gel, aluminum silica gel, veegum, laponite, and organic binders and inorganic binders. . These can mix 1 type (s) or 2 or more types, and a compounding quantity is 0.1 to 5.0% normally.

As a foaming agent (surfactant), in addition to the polyoxyethylene hydrogenated castor oil (C), other nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants Can be blended.
Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sucrose fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyethylene glycol fatty acid esters. Such as polyhydric alcohol fatty acid ester such as polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, ether type surfactant such as polyoxyethylene alkylphenyl ether, and fatty acid alkanolamides such as lauric acid diethanolamide. Can be mentioned.

  Anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid N-acyl glutamate such as sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Is mentioned.

  Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Examples of amphoteric surfactants include lauryl dimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, and coconut oil fatty acid amidopropyl. Examples include betaine.

  These surfactants can be used singly or in combination of two or more, and the blending amount thereof is appropriately selected according to the form, purpose of use and the like of the dentifrice composition of the present invention. A range in which the total blending amount with ethylene hydrogenated castor oil is 0.3 to 4.0% is preferable.

  In addition to these components, in addition to the above-mentioned specific herbal extract, (A) component glycyrrhizic acid and salts thereof, and glycyrrhetinic acid, other components do not interfere with the effects of the present invention. An effective amount can be blended within a range. Specifically, alkali metal monofluorophosphates such as sodium fluoride and sodium monofluorophosphate, fluorine compounds such as stannous fluoride, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, Enzymes such as dextranase, amylase, proteinase, mutanase, tramoxamic acid, epsilon-aminocaproic acid, aluminum chlorohydroxyallantoin, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, copper chlorophyllin Chelating phosphate compounds such as sodium, chlorophyll, glycerophosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxa Contains bactericides such as acid and its derivatives, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, cetylpyridinium chloride, benzalkonium chloride, triclosan, lysozyme chloride, and anticalculus agents such as polyphosphates and zeolites it can.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid extraction, essence, powder fragrance, etc.), and Menthol, Carvone, Anethole, Cineol, Methyl salicylate , Synamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylacetate Dehydr, citral, pregon, calbeetoacetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol , Butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate Single-flavored ingredients such as ethyl thioacetate, and strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known fragrance | flavor raw material used for a thing can be used, It is not limited to the fragrance | flavor of an Example.

  Moreover, although the compounding quantity of a fragrance | flavor is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perlartin, thaumatin, asparatylphenylalanine methyl ester and the like.

As colorants (pigments), Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204 No., Green No. 3, titanium oxide and the like.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben, methylparaben, and ethylparaben, sodium benzoate, and the like.

  In addition, the compounding quantity of a sweetener, a coloring agent, and an antiseptic | preservative can be made into a normal quantity in the range which does not prevent the effect of this invention.

  The material in particular of the container which accommodates the dentifrice composition of this invention is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In addition, unless otherwise indicated,% is the mass%. Further, sorbitol was used with a pure content of 70%, and other components were used with a pure content of 100%.

Examples and comparative examples
A dentifrice composition (toothpaste) having the composition shown in Tables 1 to 4 was prepared by the production method shown below, and the obtained dentifrice composition had anti-inflammatory effect, storage of β-glycyrrhetinic acid or dipotassium glycyrrhizinate. The following stability, the bitterness at the time of dentifrice, saltiness, and foaming were evaluated by the following methods. The results are shown in Tables 1-4.

Preparation of test dentifrice composition:
(1) A phase was prepared by mixing and dissolving water-soluble components (excluding binder, propylene glycol, etc.) in purified water at room temperature.
(2) A phase B in which a binder and a preservative were dispersed at room temperature in propylene glycol was prepared.
(3) B phase was added and mixed in A phase under stirring, and C phase was prepared.
(4) In the C phase, ingredients other than water-soluble ingredients such as fragrances, abrasives, and surfactants are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kogakusho) and decompressed (2,666 Pa). Was defoamed to obtain 1.2 kg of a dentifrice composition.

(1) Anti-inflammatory effect Using the dentifrice composition as a specimen, the rat carrageenin edema method shown below, which is a typical in vitro evaluation method as an anti-inflammatory effect determination method, was used to evaluate the efficacy of each specimen.
Rat carrageenan edema method:
Cover the head of a 5 week old female Wistar rat in good health with a hood to prevent licking, and inject 0.1 mL of 1% carrageenan solution subcutaneously into the right hind leg of the rat. Immediately measure the foot volume. It measured with the apparatus (PLETYSMOMETER, TK101 Unicom Co., Ltd. product). After the measurement, 0.5 g of the specimen was applied to the inflamed site, and the foot edema volume after 1 hour was measured. In addition, the number of animals used was 5 per group, and the edema inhibition rate was calculated according to the following criteria by calculating the ratio with respect to the edema rate without treatment at the same time as the following formula.

Edema rate (%) =
[(Edema volume at the time of measurement−Edema volume immediately after inflammation) / Edema volume immediately after inflammation] × 100
Edema suppression rate (%) =
[(Untreated edema rate−edema rate after drug treatment) / Untreated edema rate] × 100

Evaluation criteria ◎: Edema suppression rate is 60% or more ○: Edema suppression rate is 50% or more and less than 60% Δ: Edema suppression rate is 40% or more and less than 50% ×: Edema suppression rate is less than 40%

(2) Stability after storage of β-glycyrrhetinic acid The dentifrice composition is filled in a container (tube container), and β-glycyrrhetinic acid in the composition immediately after filling is quantitatively determined (%) as an initial value. The concentration in the composition of β-glycyrrhetinic acid after storage in a 60 ° C. constant temperature bath for 1 month was defined as an evaluation sample value (%), and the residual rate was calculated by the following formula. Those having a residual ratio of 90% or more were judged to have no problem in storage stability.
The β-glycyrrhetinic acid was quantified by separating 5 g of the dentifrice composition (using the first 5 g extruded from the tube), the internal standard solution (fluoranthene in methanol) and the methanol / water / acetic acid mixture (volume ratio). 900: 100: 1) was added and dispersed uniformly, followed by filtration with a 0.45 μm liquid chromatograph filter to obtain a sample solution. If necessary, it may be centrifuged after uniform dispersion. Separately, standard β-glycyrrhetinic acid was dissolved in a methanol / water / acetic acid mixture (volume ratio 900: 100: 1), diluted according to the β-glycyrrhetinic acid concentration of the composition, and then the internal standard solution was added accurately. Was used as a standard solution. The sample solution and 20 μL of the standard solution were tested by liquid chromatography under the following conditions, and QT (ratio of the peak area of β-glycyrrhetinic acid of the sample solution to the peak area of the internal standard substance) and QS (of the internal standard substance) The ratio of the peak area of β-glycyrrhetinic acid in the standard solution to the peak area was determined.

β-glycyrrhetinic acid content (%) = WS × (QT / QS) × K / WT
WS: amount of standard β-glycyrrhetinic acid (g)
WT: Sample amount (g)
K: Constant (set by dilution concentration, etc.)

Measurement conditions and equipment used Column temperature: 45 degrees Mobile phase: methanol / water / acetic acid (volume ratio 28: 11: 1)
Measurement wavelength: UV absorbance (wavelength 250 nm)
Flow rate: 1.0 mL / min Pump: PU-980 (JASCO Corporation)
Sample introduction part: AS-950 (JASCO Corporation)
Detector: UV-970 (JASCO Corporation)
Recording device: Chromatocoder 21J (System Instruments Co., Ltd.)
Column thermostatic chamber: CO-966 (JASCO Corporation)
Column: Nacalai Tesque COSMSIL 5C18
(4.6mmφ × 150mm) (Waters)

Residual rate of β-glycyrrhetinic acid (%) =
[Evaluation Sample Value (%) / Initial Value (%)] × 100

(3) Stability of dipotassium glycyrrhizinate after storage The dentifrice composition was filled in a container (tube container), and a value obtained by quantitatively determining (%) dipotassium glycyrrhizinate in the composition immediately after filling was used as the initial value. The concentration in the composition of dipotassium glycyrrhizinate after storage in a thermostatic bath at 1 ° C. for 1 month was used as an evaluation sample value (%), and the residual rate was calculated by the following formula. Those having a residual ratio of 90% or more were judged to have no problem in storage stability.
In addition, for determination of dipotassium glycyrrhizinate, 5 g of the dentifrice composition was taken (using the first 5 g extruded from the tube), an internal standard solution (ethanol solution of isoamyl parahydroxybenzoate) and 60% ethanol were added, After being uniformly dispersed, it was filtered through a 0.45 μm liquid chromatograph filter to obtain a sample solution. If necessary, it may be centrifuged after uniform dispersion. Separately, standard dipotassium glycyrrhizinate was dissolved in 60% ethanol, diluted according to the dipotassium glycyrrhizinate concentration of the composition, and then the internal standard solution was accurately added to obtain a standard solution. A 20 μL sample solution and a standard solution were tested by liquid chromatography under the following conditions, and QT (ratio of the peak area of dipotassium glycyrrhizinate in the sample solution to the peak area of the internal standard substance) and QS (peak of the internal standard substance) The ratio of the peak area of dipotassium glycyrrhizinate in the standard solution to the area was determined.

Dipotassium glycyrrhizinate content (%) = WS × (QT / QS) × K / WT
WS: Standard amount of dipotassium glycyrrhizinate (g)
WT: Sample amount (g)
K: Constant (set by dilution concentration, etc.)

Measurement conditions and equipment used Column temperature: 45 degrees Mobile phase: water / acetonitrile / glacial acetic acid (volume ratio 50: 30: 1)
Measurement wavelength: UV absorbance (wavelength 250 nm)
Flow rate: 1.0 mL / min Pump: PU-980 (JASCO Corporation)
Sample introduction part: AS-950 (JASCO Corporation)
Detector: UV-970 (JASCO Corporation)
Recording device: Chromatocoder 21J (System Instruments Co., Ltd.)
Column thermostatic chamber: CO-966 (JASCO Corporation)
Column: ODS-80Ts (4.6 mmφ × 150 mm) (Tosoh Corporation)

Residual rate of dipotassium glycyrrhizinate (%) =
[Evaluation Sample Value (%) / Initial Value (%)] × 100

(4) Evaluation of bitterness during dentifrice:
Using 10 test subjects, about 1 g of the dentifrice composition was taken on a toothbrush and brushed for about 3 minutes, and then (i) felt no bitterness, (ii) felt almost no bitterness, Responses were obtained in four stages: (iii) feeling slightly bitter, (iv) feeling very bitter. Of these answers, the following criteria are based on the average score of 10 people, with 4 points indicating no bitterness, 3 points indicating little bitterness, 2 points indicating slightly bitterness, and 1 point indicating very bitterness. The feeling of use was evaluated.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(5) Evaluation of saltiness during dentifrice:
Using 10 subjects, about 1 g of the dentifrice composition was put on a toothbrush, and after brushing for about 3 minutes, the degree of saltiness of the toothpaste was (i) moderately salty and easy to brush, (ii) slightly salty The answer was obtained in four stages: strong feeling but easy to polish, (iii) slightly salty and slightly hard to polish, and (iv) very salty and hard to polish. Of these answers, 4 points that feel moderately salty and easy to polish, 3 points that feel slightly salty but easy to polish, 2 points that feel very salty and hard to polish, 2 points that feel salty very hard and polish Using the difficulty as one point, the feeling of use was evaluated from the average score of 10 people according to the following criteria.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(6) Method for evaluating foaming during dentifrice Using 10 subjects, about 1 g of the dentifrice composition was put on a toothbrush, and foaming when brushing for 3 minutes was performed. (I) Foaming was very good, (ii) Foaming The answer was obtained in four stages: (iii) a little foaming, (iv) little foaming. Of these answers, 4 points for very good foaming, 3 points for good foaming, 2 points for slightly foaming, and 1 point for low foaming, give a feeling of use based on the following criteria from the average score of 10 people. evaluated.
◎: Average point 3.5 or more and 4.0 point or less ○: Average point 3.0 or more and less than 3.5 point △: Average point 2.0 or more and less than 3.0 point ×: Average point 1.0 point More than 2.0 points

注：表中の植物抽出物の配合量において、（ ）内の数値は各エキス量である（以下、同様。）。

Note: In the blending amount of the plant extract in the table, the numerical value in () is the amount of each extract (the same applies hereinafter).

Details of the raw materials used are as follows.
Rosemary extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Rosemary extract-J (rosemary leaf extract 0.96%, ethanol 49.52%, water 49.52%))
Sage extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Salvia extract (1% sage leaf extract, 49.5% ethanol, 49.5% water))
Ougon extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Ogon extract-J (Ougon extract 2.0%, ethanol 49%, water 49%))
Carrot extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Carrot extract (Ginseng root extract 2.5%, ethanol 48.75%, water 48.75%))
Peonies extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Peonies extract-J (peony root extract 3.5%, ethanol 48.25%, water 48.25%))
Mukuroji extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Mukuroji extract powder (100% Mukuroji extract))
Toki extract: Maruzen Pharmaceutical Co., Ltd. (trade name: Toki extract-JC (Toki root extract 2.5%, ethanol 48.75%, water 48.75%))
β-glycyrrhetinic acid: Maruzen Pharmaceutical Co., Ltd.
Dipotassium glycyrrhizinate: Maruzen Pharmaceutical Co., Ltd.
Sodium chloride: Iki Salt Industry Co., Ltd.
Polyoxyethylene (10) hydrogenated castor oil: Nippon Chemicals Co., Ltd.
Polyoxyethylene (20) hydrogenated castor oil: Nippon Chemicals Co., Ltd.
Polyoxyethylene (30) hydrogenated castor oil: Nippon Chemicals Co., Ltd.
Polyoxyethylene (60) hydrogenated castor oil: Nippon Chemicals Co., Ltd.
As for other components, standard products of quasi-drug raw material standards were used.

Claims (2)

  Toothpaste composition formulated with water and / or organic solvent extract of plant selected from rosemary, sage, oxon, carrot, peony, mukuroji, touki, selected from (A) glycyrrhizic acid and its salt, glycyrrhetinic acid 1 or more, (B) sodium chloride, and (C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 5 to 30, and (B) component / (C) component mass ratio The dentifrice composition characterized by having 0.3 to 20.   The dentifrice composition of Claim 1 which mix | blended 0.01-0.5 mass% of (A) component, 0.5-15 mass% of (B) component, and 0.3-3 mass% of (C) component. object.