JP2011153138A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for oral cavity in which stain adsorption to a tooth based on cetylpyridinium chloride can be controlled while promoting adsorption to a tooth of cetylpyridinium chloride. <P>SOLUTION: The composition for oral cavity includes: 0.1-0.5 mass% of cetylpyridinium chloride; and 0.2-2 mass% of glycyrrhizic acid or its salt. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an oral composition, and more particularly to an oral composition containing cetylpyridinium chloride and glycyrrhizic acid or a salt thereof.

  Cetylpyridinium chloride (CPC), a cationic fungicide, has high bactericidal activity against oral bacteria, adsorbs to the oral mucosa and tooth surface, inhibits the adsorption of oral bacteria to the tooth surface, and suppresses the formation of plaque It is known to do.

  Conventionally, various methods for increasing the activity of cationic fungicides have been disclosed. Patent Document 1 describes that when cetylpyridinium chloride is combined with a lower alkyl ester of an N-long-chain acyl basic amino acid or a salt thereof, adsorption of cetylpyridinium chloride to a tooth is promoted. Patent Document 2 discloses that the action of promoting the adsorption of a cationic bactericide on a tooth by a lower alkyl ester of an N-long chain acyl basic amino acid or a salt thereof is most enhanced in the region of pH 5.5 to 6.5. Is described.

However, the protein film (pelicle) contained in saliva and covering the teeth is insolubilized by adsorption of cationic fungicides such as cetylpyridinium chloride and polyphenols contained in tea, etc., and adheres firmly to the tooth surface. In addition, it is known that coloring occurs when metal ions such as iron are present. For this reason, promoting the adsorption of cetylpyridinium chloride to the tooth can provide the merit of inhibiting the formation of plaque by inhibiting the adsorption of oral bacteria to the tooth surface, while promoting the adsorption of stain to the tooth. , There was a problem that the appearance of the teeth deteriorated by coloring. (Hereinafter, the adsorption of stains to teeth promoted by the presence of cetylpyridinium chloride is referred to as “stain adsorption to teeth based on cetylpyridinium chloride” or “stain adsorption to teeth by cetylpyridinium chloride”, etc. Say.)
Therefore, there has been a demand for an oral composition that can promote (or reduce) the adsorption of stain to teeth based on cetylpyridinium chloride while promoting the adsorption of cetylpyridinium chloride to teeth.

JP-A-4-36231 JP-A-9-286712

  An object of the present invention is to provide an oral composition that can promote the adsorption of cetylpyridinium chloride to a tooth while suppressing the adsorption of stain to a tooth based on cetylpyridinium chloride.

  The inventors surprisingly found that oral compositions containing specific amounts of cetylpyridinium chloride and glycyrrhizic acid or salts thereof are based on cetylpyridinium chloride while promoting adsorption of cetylpyridinium chloride to teeth. It has been found that stain adsorption to teeth can be suppressed, and further improvements have been made to complete the present invention.

That is, the present invention relates to a composition for oral cavity and a method described in the following section.
Item 1.
An oral composition containing 0.1 to 0.5% by mass of cetylpyridinium chloride and 0.2 to 2% by mass of glycyrrhizic acid or a salt thereof.
Item 2.
The composition for oral cavity of Claim 1 which contains 0.7-7 mass parts of glycyrrhizic acid or its salt per 1 mass part of cetyl pyridinium chloride.
Item 3.
Containing 0.3 to 0.5 mass% of glycyrrhizic acid or a salt thereof,
Item 3. The oral cavity composition according to Item 2, comprising 1 to 4 parts by mass of glycyrrhizic acid or a salt thereof per 1 part by mass of cetylpyridinium chloride.
Claim | item 4-1.
Item 4. A method for promoting adsorption of cetylpyridinium chloride to a tooth by using the oral composition according to any one of Items 1 to 3.
Item 4-2.
Item 4. A method for suppressing stain adsorption to a tooth based on cetylpyridinium chloride by using the oral composition according to any one of Items 1 to 3.
Item 4-3.
0.1 to 0.5% by mass of cetylpyridinium chloride including a step of blending glycyrrhizic acid or a salt thereof so that 0.2 to 2.0% by mass of glycyrrhizic acid or a salt thereof is contained in the oral composition. A method for promoting adsorption of cetylpyridinium chloride to a tooth during use of a composition for oral cavity.
Item 4-4.
0.1 to 0.5% by mass of cetylpyridinium chloride including a step of blending glycyrrhizic acid or a salt thereof so that 0.2 to 2.0% by mass of glycyrrhizic acid or a salt thereof is contained in the oral composition. A method for reducing the adsorption of stain to teeth by cetylpyridinium chloride when using a composition for oral cavity.
Item 5-1.
Composition for oral cavity in which adsorption of cetylpyridinium chloride to teeth is increased by blending 0.1 to 0.5% by mass of cetylpyridinium chloride and 0.2 to 2.0% by mass of glycyrrhizic acid or a salt thereof. How to manufacture.
Item 5-2.
Oral for oral use that reduces stain adsorption to teeth based on cetylpyridinium chloride by blending 0.1 to 0.5% by mass of cetylpyridinium chloride and 0.2 to 2.0% by mass of glycyrrhizic acid or a salt thereof A method for producing a composition.
Item 5-3.
Containing 0.1 to 0.5% by mass of cetylpyridinium chloride, including a step of blending so that glycyrrhizic acid or a salt thereof is contained in the oral composition in an amount of 0.2 to 2.0% by mass; A method for producing an oral composition having increased adsorption of cetylpyridinium to teeth.
Item 5-4.
Containing 0.1 to 0.5% by mass of cetylpyridinium chloride, including a step of blending glycyrrhizic acid or a salt thereof in the oral composition so as to be contained by 0.2 to 2.0% by mass; A method for producing an oral composition in which stain adsorption to teeth by cetylpyridinium is reduced.
Item 6-1.
A tooth adsorption accelerator for cetylpyridinium chloride, comprising glycyrrhizic acid or a salt thereof.
Item 6-2.
An inhibitor of stain adsorption to teeth based on cetylpyridinium chloride, comprising glycyrrhizic acid or a salt thereof.
Claim | item 6-3.
Dental dentistry for promoting dental adsorption of cetylpyridinium chloride, comprising glycyrrhizic acid or a salt thereof.
Item 6-4.
A dental oral medicine for suppressing stain adsorption to teeth based on cetylpyridinium chloride, comprising glycyrrhizic acid or a salt thereof.

  The oral composition containing cetylpyridinium chloride and glycyrrhizic acid or a salt thereof according to the present invention can promote adsorption of cetylpyridinium chloride to teeth, but can suppress stain adsorption to teeth based on cetylpyridinium chloride. . Furthermore, the bactericidal power of cetylpyridinium chloride does not change. Therefore, by using the oral composition, the adsorption of cetylpyridinium chloride to teeth is promoted while maintaining the bactericidal power of cetylpyridinium chloride, and the stain adsorption to teeth based on cetylpyridinium chloride is suppressed. It becomes possible.

The examination result of the stain adsorption to the tooth based on CPC is shown. Specifically, the results of an experiment in which an acrylic plate is regarded as a tooth and the operation of immersing it in each solution sample and black tea was repeated, and the absorbance was measured each time. The examination result of adsorption | suction to the tooth | gear of CPC is shown. Specifically, the hydroxyapatite powder is regarded as a tooth, immersed in each solution sample, the amount of CPC adsorbed on the powder is measured, and the adsorption rate calculated based on this is shown. The examination result of adsorption | suction to the tooth | gear of CPC is shown. Specifically, the hydroxyapatite powder is regarded as a tooth, immersed in each solution sample, the amount of CPC adsorbed on the powder is measured, and the CPC adsorption acceleration rate calculated based on this is shown. The examination result of the stain adsorption to the tooth based on CPC is shown. Specifically, the results of an experiment in which an acrylic plate is regarded as a tooth and the operation of immersing it in each mouthwash and black tea was repeated, and the absorbance was measured each time.

  Hereinafter, the present invention will be described in more detail.

  The composition for oral cavity of the present invention contains cetylpyridinium chloride and glycyrrhizic acid or a salt thereof.

  Cetylpyridinium chloride is a cationic bactericidal component contained in quaternary ammonium compounds, and is widely used in the field of oral compositions. The content of cetylpyridinium chloride in the oral composition of the present invention is not particularly limited, but the effect of the present invention is particularly preferably exerted in an amount in which stain adsorption to a tooth based on cetylpyridinium chloride is a problem. , Preferably 0.1 to 0.5% by mass, more preferably 0.1 to 0.4% by mass, further preferably 0.1 to 0.3% by mass, and still more preferably 0.15 to 0.3%. % By mass.

  Glycyrrhizic acid is an active ingredient contained in licorice root, and is known to have anti-inflammatory action. Further, glycyrrhizic acid salts are also known to have anti-inflammatory effects. The salt of glycyrrhizic acid contained in the oral composition of the present invention is not particularly limited as long as the effects of the present invention are not impaired, and examples thereof include potassium salts, sodium salts, ammonium salts and the like. Specific examples include dipotassium glycyrrhizinate, disodium glycyrrhizinate, and monoammonium glycyrrhizinate. Of these, dipotassium glycyrrhizinate is preferable.

  In the oral composition of the present invention, glycyrrhizic acid or a salt thereof promotes tooth adsorption of cetylpyridinium chloride. Furthermore, in the composition for oral cavity of the present invention, glycyrrhizic acid or a salt thereof suppresses stain adsorption to teeth based on cetylpyridinium chloride.

  The content of glycyrrhizic acid or a salt thereof in the oral composition of the present invention is not particularly limited, and can be appropriately set according to the amount of cetylpyridinium chloride contained in the oral composition. The content of glycyrrhizic acid or a salt thereof is preferably 0.2 to 2% by mass, more preferably 0.3 to 1% by mass, still more preferably 0.3 to 0.8% by mass, and still more preferably 0.00. 3 to 0.5% by mass.

  Furthermore, the amount of glycyrrhizic acid or a salt thereof can be appropriately set according to the amount of cetylpyridinium chloride. For example, when the content of cetylpyridinium chloride is 1 part by mass, the content of glycyrrhizic acid or a salt thereof is preferably 0.7 to 7 parts by mass, more preferably 0.7 to 6.7 parts by mass, and still more preferably Is 1 to 4 parts by mass, more preferably 1 to 2.7 parts by mass. In other words, the mass ratio of (glycyrrhizic acid or a salt thereof / cetylpyridinium chloride) is preferably 0.7 to 7, more preferably 0.7 to 6.7, still more preferably 1 to 4, and even more preferably. 1 to 2.7.

  The oral composition of the present invention can be used as, for example, a pharmaceutical product or a quasi-drug. Particularly preferred are pharmaceuticals. Further, the form of the composition for oral cavity of the present invention is not particularly limited, but for example, an ointment, paste, pasta, gel, liquid, spray, mouthwash, liquid dentifrice, It can be in a form (dosage form) such as a toothpaste or gum. Of these, mouthwash, liquid dentifrice, toothpaste, ointment, paste, liquid, spray, and gel are preferred.

  As described above, the oral composition of the present invention promotes the adsorption of cetylpyridinium chloride to teeth while maintaining the sterilizing power of cetylpyridinium chloride, and suppresses the adsorption of stain to teeth based on cetylpyridinium chloride. It is possible. Furthermore, glycyrrhizic acid or a salt thereof has an anti-inflammatory effect. Therefore, the composition for oral cavity of the present invention can be suitably used for oral care as an anti-inflammatory agent or bactericidal agent for oral cavity. In particular, it can be preferably used as a dental oral medicine such as alveolar purulent medicine for alleviation of various symptoms associated with periodontal disease, periodontitis, and / or gingivitis. Examples of the symptoms include gingival bleeding, redness, swelling, itchiness, pain, itching, or stickiness of the mouth, bad breath, and the like. It can also be preferably used for treatment and / or alleviation of stomatitis.

  The oral composition of the present invention may further contain, in addition to cetylpyridinium chloride and glycyrrhizic acid or a salt thereof, optional components that can be blended in the oral composition within a range not impairing the effects of the present invention.

  For example, a nonionic surfactant, an anionic surfactant or an amphoteric surfactant can be blended as the surfactant. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters; fatty acid alkanolamides; sorbitan fatty acid esters; fatty acid monoglycerides; A polyoxyethylene alkyl ether having an alkyl group having 13 to 15 carbon atoms; a polyoxyethylene addition coefficient of 10 to 18 and a polyoxyethylene alkyl phenyl ether having an alkyl group having 9 carbon atoms; diethyl sebacate; polyoxy Ethylene hydrogenated castor oil; fatty acid polyoxyethylene sorbitan and the like. Anionic surfactants include sulfate esters such as sodium lauryl sulfate and polyoxyethylene lauryl ether sulfate; sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate; cocoyl sarcosine sodium and lauroylmethylalanine Acyl amino acid salts such as sodium; cocoyl methyl taurine sodium and the like. Zwitterionic surfactants include betaine acetate type activators such as lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine; imidazoline type such as N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium Activating agents; amino acid type activating agents such as N-lauryldiaminoethylglycine. These surfactants can be blended alone or in combination of two or more. The compounding quantity is 0.1-5 mass% normally with respect to the composition whole quantity.

  As flavoring agents, menthol, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, ocimen, n-decyl alcohol, citronell, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, ethyl linalool , Thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, Perfumes such as fennel oil, cinnamon oil, cinnamaldehyde, mint oil, and vanillin can be blended in an amount of 0.01 to 1.5% by mass based on the total amount of the composition alone or in combination of two or more.

  In addition, sweeteners such as saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, perilartin, thaumatin, asparatylphenylalanyl methyl ester, p-methoxycinnamic aldehyde, etc. are 0.001 to 1 based on the total amount of the composition. It can mix | blend the mass%.

  Furthermore, as a wetting agent, sorbit, ethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, polypropylene glycol, xylite, maltite, lactit, polyoxyethylene glycol, etc. can be blended alone or in combination of two or more. it can.

  As preservatives, parabens such as methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like can be blended.

  As colorants, legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3, mineral pigments such as ultramarine blue, enhanced ultramarine blue, and bitumen, and titanium oxide may be blended.

  As a pH adjuster, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or a chemically possible salt thereof, sodium hydroxide, or the like may be blended. These can be blended singly or in combination of two or more so that the pH of the composition is in the range of 4-8, preferably 5-7. The normal amount of the pH adjuster is 0.01 to 2% by weight.

  The oral composition of the present invention further includes, as a medicinal component, vitamin E such as dl-α-tocopherol acetate, tocopherol succinate or tocopherol nicotinate, an amphoteric fungicide such as dodecyldiaminoethylglycine, triclosan , Nonionic fungicides such as isopropylmethylphenol, enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (Litec Enzyme), alkali metal mono, such as sodium monofluorophosphate and potassium monofluorophosphate Fluorophosphates, fluorides such as sodium fluoride and stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhetinic acid, glycerophosphine Over DOO, chlorophyll, sodium chloride, Karopeputaido, allantoin, carbazochrome, hinokitiol, potassium nitrate, and Palatinit like, can be blended alone or in combination of two or more.

  In addition, alcohols, silicon, apatite, white petrolatum, paraffin, liquid paraffin, microcrystalline wax, squalane and the like can be added as a base.

  As described above, glycyrrhizic acid or a salt thereof promotes tooth adsorption of cetylpyridinium chloride, and further suppresses stain adsorption to teeth based on cetylpyridinium chloride. Accordingly, the present invention also includes a cetylpyridinium chloride tooth adsorption promoter comprising glycyrrhizic acid or a salt thereof. Furthermore, this invention also includes the stain adsorption inhibitor to the tooth based on cetylpyridinium chloride which consists of glycyrrhizic acid or its salt. Specific examples of salts of glycyrrhizic acid used as these agents include the same as those described above.

  These agents can be preferably used particularly when an oral composition containing cetylpyridinium chloride is produced or applied to the oral cavity. That is, in producing an oral composition containing cetylpyridinium chloride, by mixing cetylpyridinium chloride and glycyrrhizic acid or a salt thereof together, tooth adsorption of cetylpyridinium chloride when using the oral composition is achieved. It is possible to promote and / or suppress stain adsorption to teeth based on cetylpyridinium chloride when using the oral composition. In addition, as a form of the composition for oral cavity here, the thing similar to what was mentioned above specifically, is mentioned, for example. Moreover, manufacture of the composition for oral cavity here can also be performed in accordance with a conventional method like the above-mentioned.

  In addition, the amount of glycyrrhizic acid or a salt thereof used as these agents is not particularly limited, and can be appropriately set according to the amount of cetylpyridinium chloride. For example, when the amount of cetylpyridinium chloride used is 1 part by mass, the preferred range of the amount of glycyrrhizic acid or its salt is (in other words, the preferred range of the mass ratio of (glycyrrhizic acid or its salt / cetylpyridinium chloride) Is the same as the case of blending into the above-mentioned composition for oral cavity.

  Furthermore, the present invention also includes (i) a method of promoting adsorption of cetylpyridinium chloride to a tooth by using the above oral composition. Moreover, this invention also includes the method of suppressing the stain adsorption | suction to the tooth based on (ii) cetyl pyridinium chloride by using the said composition for oral cavity.

  Moreover, this invention includes the process of mix | blending glycyrrhizic acid or its salt so that (iii) glycyrrhizic acid or its salt may be contained in the composition for oral cavity (preferably 0.2-2.0 mass%). Also included is a method of promoting adsorption of cetylpyridinium chloride to teeth when using an oral composition containing cetylpyridinium chloride (preferably 0.1 to 0.5% by mass). Further, the present invention includes (iv) a step of blending glycyrrhizic acid or a salt thereof so that glycyrrhizic acid or a salt thereof is contained in the oral composition (preferably 0.2 to 2.0% by mass). Also included is a method for reducing the adsorption of stain to teeth by cetylpyridinium chloride when using an oral composition containing cetylpyridinium chloride (preferably 0.1 to 0.5% by mass). In the methods (iii) and (iv), the order of adding glycyrrhizic acid or a salt thereof and cetylpyridinium chloride is not particularly limited. That is, in these methods, cetylpyridinium chloride may be blended or not blended at the time of blending glycyrrhizic acid or a salt thereof.

  In the present invention, (v) cetylpyridinium chloride (preferably 0.1 to 0.5% by mass) and glycyrrhizic acid or a salt thereof (preferably 0.2 to 2.0% by mass) are blended. Thus, a method for producing an oral composition having increased adsorption of cetylpyridinium chloride to teeth is included. Moreover, this invention mix | blends (vi) cetyl pyridinium chloride (preferably 0.1-0.5 mass%), and glycyrrhizic acid or its salt (preferably 0.2-2.0 mass%). By the above, the method of manufacturing the composition for oral cavity which reduced the stain adsorption | suction to the tooth based on cetyl pyridinium chloride is also included.

  Furthermore, the present invention provides (vii) cetylpyridinium chloride (preferably including a step of blending so that glycyrrhizic acid or a salt thereof is contained in the oral composition (preferably 0.2 to 2.0% by mass). Includes 0.1 to 0.5% by mass) and includes a method for producing a composition for oral cavity in which adsorption of cetylpyridinium chloride to teeth is increased. The present invention also relates to (viii) cetylpyridinium chloride comprising a step of blending glycyrrhizic acid or a salt thereof so as to be contained in the oral composition (preferably 0.2 to 2.0% by mass) ( A method for producing an oral composition containing 0.1 to 0.5% by mass) and having reduced stain adsorption to teeth by cetylpyridinium chloride is also included. In the methods (v) to (viii), the order of adding glycyrrhizic acid or a salt thereof and cetylpyridinium chloride is not particularly limited. That is, in these methods, if glycyrrhizic acid or a salt thereof (preferably 0.2 to 2.0% by mass) is contained in the manufactured oral composition, glycyrrhizic acid or a salt thereof is blended. At that time, the cetylpyridinium chloride may or may not be blended.

  In the methods (iii) to (viii), it is preferable that the oral composition obtained by these methods satisfies various conditions such as the above-described various component contents and mass ratios.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. “CPC” represents cetylpyridinium chloride, and “GK2” represents dipotassium glycyrrhizinate. Unless otherwise specified, “%” indicates “mass%”.

<Examination of stain adsorption to teeth based on CPC>
According to the composition described in Table 1, CPC and GK2 were dissolved in purified water to prepare 11 types of sample solutions (Examples 1-1 to 1-5 and Comparative Examples 1-A to 1-F). In addition, Comparative Example 1-A is purified water.

  These sample solutions were tested according to the following test method to examine whether GK2 can suppress stain adsorption based on CPC. The adsorption of stain was measured by the intensity of the absorbance (the greater the absorbance, the more the stain adsorption is occurring).

〔Test method〕
An acrylic plate (10 mm × 30 mm × 5 mm) was immersed in 0.3% bovine serum albumin for 2 minutes. The acrylic plate was washed by immersing it in distilled water for 30 seconds, and then immersed in each sample solution for 2 minutes. The acrylic plate was washed by immersing it in distilled water for 30 seconds, and then immersed in black tea (extracted with [10 g dried tea leaves / 1000 mL boiling water] for 2 minutes) for 60 minutes. The acrylic plate was washed by immersing it in distilled water for 30 seconds and then naturally dried, and the absorbance of the acrylic plate surface was measured (measurement wavelength: 395 nm).

  These operations were repeated 10 times.

  The results are also shown in Table 1 (“Absorbance” in Table 1 indicates the value obtained in the 10th measurement). A graph of the results is shown in FIG.

  From Table 1 and FIG. 1, it was found that the greater the amount of GK2 relative to the amount of CPC, the more the CPC-based stain adsorption was suppressed.

<Examination of adsorption of CPC on teeth>
In accordance with the composition described in Table 2, CPC and GK2 were dissolved in purified water to prepare 11 types of sample solutions (Examples 2-1 to 2-7 and Comparative Examples 2-A to 2-D). Comparative Example 2-A is the same as Comparative Example 1-D, and Example 2-3 is the same as Example 1-5.

  Using these sample solutions, a test was performed according to the following test method to examine whether GK2 can promote adsorption of CPC to teeth.

〔Test method〕
300 mg of hydroxyapatite (DNA GradeBio-Gel HTP; manufactured by BIO-RAD) was immersed in 2 mL of human saliva sterilized by ultraviolet light at 37 ° C. for 15 hours to form a pellicle on the hydroxyapatite surface. Thereafter, the mixture was centrifuged (3000 rpm, 10 minutes) to precipitate hydroxyapatite, and the supernatant was removed. Next, the hydroxyapatite was immersed in 2 mL of each solution sample at 37 ° C. for 15 minutes. After centrifugation (3000 rpm, 10 minutes), the supernatant was discarded, 2 mL of distilled water was added, and the mixture was stirred and then centrifuged (3000 rpm, 10 minutes). Further, the supernatant was discarded, 2 mL of distilled water was added, the mixture was stirred and then centrifuged (3000 rpm, 10 minutes), and the supernatant was discarded.

  Next, 5 mL of the following extract was added, stirred and centrifuged, and the supernatant was transferred to a 50 mL volumetric flask. The same operation was repeated twice, CPC was extracted, and the amount of CPC adsorbed on 300 mg of hydroxyapatite was determined by quantifying by HPLC using a sample that was made up with an extract.

[Extract]
Solution in which 2.88 g of sodium lauryl sulfate was dissolved per liter of 0.02 M citrate buffer at pH 3: acetonitrile = 1: 3

And the said adsorption amount was compared with the theoretical value, and the adsorption rate and the CPC adsorption acceleration rate were computed from the following formula. The theoretical value is the total amount of CPC theoretically contained in 2 mL of the solution sample.
Adsorption rate = (adsorption amount / theoretical value) × 100 [%]

CPC adsorption acceleration rate = (adsorption rate of each solution sample) − (adsorption rate of Comparative Example 2-A) [%]

* Comparative Example 2-A does not contain GK2.

  The results are also shown in Table 2. A graph of the results is shown in FIG.

  From Table 2 and FIG. 2, it was found that the adsorption of CPC to the teeth is promoted or suppressed depending on the amount of GK2 with respect to the amount of CPC. Furthermore, by calculating from Table 2, when the amount of CPC was 1 part by mass, it was found that when the amount of GK2 was 0.7 to 6.7 parts by mass, adsorption of CPC to teeth was promoted. . Moreover, when the amount of CPC was 1 part by mass, it was also found that when the amount of GK2 was 1 to 3.3 parts by mass, the adsorption of CPC to the teeth was particularly promoted.

  CPC has a bactericidal action and is adsorbed on the tooth surface to inhibit the adsorption of oral bacteria on the tooth surface and suppress the formation of plaque. Therefore, accelerating the adsorption of CPC to the teeth can be said to enhance the adsorption inhibition action of oral bacteria and enhance the plaque formation inhibition action.

<Examination of prescription>
According to the composition described in Table 3, CPC, GK2 and other components were dissolved in purified water to prepare six types of solution samples (Examples 3-1 to 3-5 and Comparative Example 3-A). Moreover, the commercially available mouthwash P was used as Comparative Example 3-B. The mouthwash liquid P contains 0.07% by mass of CPC. In addition, the numerical value of Table 3 shows the mass%.

  In the same manner as the test method performed in “Examination of stain adsorption to teeth based on CPC”, the stain adsorption of each solution sample (mouth rinse solution) was measured by the intensity of absorbance. The results are shown in Table 4 and FIG.

As for the mouthwash liquid agent (Examples 3-1 to 3-5) which mix | blended GK2, as for all, stain adsorption | suction was suppressed. On the other hand, in the mouthwash solution containing no GK2 (Comparative Example 3-A), stain adsorption based on CPC (stain adsorption by CPC) was observed. In addition, a commercially available mouthwash P (Comparative Example 3-B) also showed stain adsorption based on CPC.

  Below, a prescription example is described. The numerical value of each component in the formulation example indicates mass%. Moreover, in the following prescription examples, pH was adjusted to 5.5-7.0 with the pH adjuster.

Claims (7)

An oral composition containing 0.1 to 0.5% by mass of cetylpyridinium chloride and 0.2 to 2% by mass of glycyrrhizic acid or a salt thereof. The composition for oral cavity of Claim 1 which contains 0.7-7 mass parts of glycyrrhizic acid or its salt per 1 mass part of cetyl pyridinium chloride. Containing 0.3 to 0.5 mass% of glycyrrhizic acid or a salt thereof,
The composition for oral cavity of Claim 2 which contains 1-4 mass parts of glycyrrhizic acid or its salt per 1 mass part of cetyl pyridinium chloride. Containing 0.1 to 0.5% by mass of cetylpyridinium chloride, including a step of blending so that glycyrrhizic acid or a salt thereof is contained in the oral composition in an amount of 0.2 to 2.0% by mass; A method for producing an oral composition having increased adsorption of cetylpyridinium to teeth. Containing 0.1 to 0.5% by mass of cetylpyridinium chloride, including a step of blending glycyrrhizic acid or a salt thereof in the oral composition so as to be contained by 0.2 to 2.0% by mass; A method for producing an oral composition in which stain adsorption to teeth by cetylpyridinium is reduced. 0.1 to 0.5% by mass of cetylpyridinium chloride including a step of blending glycyrrhizic acid or a salt thereof so that 0.2 to 2.0% by mass of glycyrrhizic acid or a salt thereof is contained in the oral composition. A method for promoting adsorption of cetylpyridinium chloride to a tooth during use of a composition for oral cavity. 0.1 to 0.5% by mass of cetylpyridinium chloride including a step of blending glycyrrhizic acid or a salt thereof so that 0.2 to 2.0% by mass of glycyrrhizic acid or a salt thereof is contained in the oral composition. A method for reducing the adsorption of stain to teeth by cetylpyridinium chloride when using a composition for oral cavity.

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