JP2002338457A - Prophylactic/therapeutic agent for periodontosis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a prophylactic/therapeutic agent for periodontoses enabling periodontoses to be mitigated or ameliorated in a short period, thus having excellent prophylactic/therapeutic effects on the periodontoses, and to provide an oral cavity composition including the agent and therefore also having excellent prophylactic/therapeutic effects on the periodontoses. SOLUTION: This prophylactic/therapeutic agent for periodontoses comprises a sesquiterpene alcohol having a cedrene skeleton.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an agent for preventing and treating periodontal disease.

[0002]

2. Description of the Related Art Periodontal disease is a multifactorial disease consisting of factors, environment, host and the like. Therapeutic agents include, for example, tranexamic acid, allantoin, epsilon for the purpose of disinfecting periodontopathic bacteria, improving blood flow of periodontal tissue, activating tissue, improving inflammation, preventing bleeding, etc. Pharmaceutical ingredients such as aminocaproic acid, lysozyme, sodium chloride, dihydrocholesterol, and β-glycyrrhetinic acid have been used.

[0003]

However, in the lesion of periodontal disease, periodontopathic bacteria form a biofilm and have resistance to bactericidal and antibacterial agents, and preventive and therapeutic effects of periodontal disease Is not enough (The Quint Essence
(the Quintessence) Volume 16, Issue 11, 2629-264
0, 1997). An object of the present invention is to provide a prophylactic and / or therapeutic agent for periodontal disease excellent in periodontal disease induced by periodontal pathogenic bacteria forming a biofilm.

[0004]

DISCLOSURE OF THE INVENTION The present inventors have found that certain sesquiterpene alcohols are extremely effective in preventing and treating periodontal disease. The present invention provides a prophylactic / therapeutic agent for periodontal disease comprising a sesquiterpene alcohol having a sedren skeleton or an aromadendrene skeleton, and an oral composition containing the same.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Examples of sesquiterpene alcohols having a cedrene skeleton used in the present invention include cedrol and cedrenol.

[0006] The sesquiterpene alcohols having a sedren skeleton used in the present invention are essential oils containing sesquiterpene alcohols having a sedrene skeleton obtained by extraction from plants or by steam distillation, such as hay oil, cedar oil, and cedar wood oil. , May be used essential oils such as cade oil, granberry oil, lemon oil,
Further, these fermented products may be used. Here, the fermented product is obtained, for example, by allowing a microorganism belonging to the genus Rhodococcus to act on α-sedren (Japanese Patent Laid-Open No. 4-365).
488).

The sesquiterpene alcohols having an aromadendrene skeleton used in the present invention include globulol, redolol, and pulse tol. Sesquiterpene alcohols having an aromadendrene skeleton used in the present invention include eucalyptus, teninka,
Essential oils such as eucalyptus oil, eucalyptus extract, tenninka extract, salvia extract, and sage extract obtained by extraction or steam distillation from plants such as salvia and sage may be used.

The prophylactic / therapeutic agent for periodontal disease of the present invention is further formulated into a formulation containing bases such as oils and fats, lanolin, petrolatum, paraffin, wax, resin, glycols, higher alcohols, glycerin, water and emulsifiers. You may.

The oral composition of the present invention contains a sesquiterpene alcohol having a sedren skeleton or an aromadendrene skeleton as an active ingredient for preventing periodontal disease.
In the case of sesquiterpene alcohols having a sedrene skeleton, preferably 0.06-
The content is preferably 6% by weight, particularly preferably 0.1 to 1% by weight. In the case of sesquiterpene alcohols having an aromadendrene skeleton, the oral composition of the present invention preferably contains 0.001 to 5% by weight, particularly 0.01 to 0.5% by weight.
It is preferred that the content be contained by weight. In addition, two kinds of sesquiterpene alcohols may be used in combination.

The oral composition of the present invention comprises an ointment, a toothpaste, and a liquid dentifrice, together with sesquiterpene alcohols having a sedren skeleton or an aromadendrene skeleton, as well as components to be added to ordinary oral compositions. , Mouthwash, oral pasta, gum massage cream and the like are preferable.

Among the components used in an appropriate amount according to the purpose of use, particularly preferred components are calcium carbonate, aluminum hydroxide, silicic anhydride, hydrous silicic acid, and dibasic calcium phosphate, which can provide a synergistic effect by plaque control. Abrasives such as dihydrate, dibasic calcium phosphate (anhydride), alumina, etc., benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, isopropylmethylphenol, alkyldiaminoethyl glycine hydrochloride And bactericides such as decalinium chloride. Furthermore, anti-inflammatory agents such as allantoin, allantoinchlorohydroxyaluminum, glycyrrhizic acid, β-glycyrrhetinic acid, dihydrocholesterol, and lysozyme chloride also have a synergistic effect of improving periodontal disease.

Sesquiterpene alcohols are hardly soluble in water. To promote dissolution, anionic surfactants such as sodium lauryl sulfate and lauroylglutamic acid, sucrose fatty acid esters, monoglycerin fatty acid esters, polyglycerin fatty acid esters, etc. It is preferable to use a nonionic surfactant such as sorbitan fatty acid ester, hydrogenated castor oil, and polyoxyethylene polyoxypropylene glycol in combination.

As excipients, carboxymethylcellulose, hydroxyethylcellulose, carrageenan, xanthan gum, sodium alginate, sodium polyacrylate, polyethylene glycol, polyvinylpyrrolidone, silica gel, gelled hydrocarbon (liquid paraffin gelled with polyethylene resin) ), Vaseline and the like are preferably used in combination.

As a flavor component for masking a unique flavor or enhancing palatability, menthol, peppermint oil, spearmint oil, clove oil, cinnamon oil, orange oil, anise oil, lemon oil, anethole, cassia oil, A combination of saccharin sodium, stevioside, aspartame and the like is preferred.

In addition, it is preferable to appropriately use a humectant such as glycerin, sorbitol, xylitol, propylene glycol or polyethylene glycol, or a preservative such as parabens or sodium benzoate.

[0016]

EXAMPLES The preventive and therapeutic agents for periodontal disease shown in Table 1 were produced.

[0017]

[Table 1]

Effect on Periodontal Disease 0.5 g of a preventive / therapeutic agent for periodontal disease in Table 1 was applied to gums of five men with periodontal disease every 12 hours in the morning and evening. The gum condition was diagnosed by palpation and visual inspection and indexed according to the following evaluation criteria. Evaluation criteria 0: No inflammation 1: Mild inflammation-slight change in gingival color and surface morphology 2: Moderate inflammation-Moderate gingival surface gloss, redness, edema and swelling. Compression bleeding 3: Severe inflammation-marked redness and swelling, propensity for sporadic bleeding, and ulcer mean score Six representative teeth of the oral cavity (left upper first molar, left incisor, upper jaw,
The right first premolar and the lower left first premolar, the right incisor, the right first molar) of the mandible are limited to a total of 4 faces (buccal, lingual, mesial, distal). Twenty-four sites were diagnosed, and the average value of all the evaluation points of five subjects was used as an index of the effect on periodontal disease.

Table 1 shows the average evaluation points. All the products of the present invention showed a remarkable periodontal disease improving effect in a short period of time. In the product 1 of the present invention, 15 sites where inflammation with an evaluation point of 2 or more was observed before the start of the test were all improved to 1 or less on the 7th day from the start of application. In the same way, the same 14 and 15 sites were all scored 1 on the seventh day.
Because of the following improvements, a remarkable periodontal disease-improving effect was observed, especially for moderate and severe inflammation.

Example 2 A gum massage cream having the following composition was produced. Cedrol 0.2% by weight Gelated hydrocarbon 56 Glycerin 20 Sucrose fatty acid ester 5 Fragrance 0.7 Saccharin sodium 0.1 This gum massage cream had a remarkable periodontal disease improving effect.

[0021]

The prophylactic / therapeutic agent for periodontal disease of the present invention can reduce and improve periodontal disease in a short period of time and is excellent in the effect of preventing and treating periodontal disease.
In addition, an oral composition containing the same is also excellent in periodontal disease preventing effect.

 ────────────────────────────────────────────────── ─── Continuing from the front page (72) Inventor Hiromi Kubota 2606 Akabane, Kaigamachi, Haga-gun, Tochigi Pref.

Claims (6)

[Claims] 1. A prophylactic or therapeutic agent for periodontal disease comprising a sesquiterpene alcohol having a sedren skeleton or an aromadendrene skeleton. 2. The prophylactic / therapeutic agent for periodontal disease according to claim 1, wherein the sesquiterpene alcohol having a sedren skeleton is cedrenol or cedrol. 3. The prophylactic / therapeutic agent for periodontal disease according to claim 1, wherein the sesquiterpene alcohol having an aromadendrene skeleton is globulol, redolol or pulse tol. 4. An oral composition comprising the prophylactic / therapeutic agent for periodontal disease according to claim 1. 5. The oral composition according to claim 4, wherein the content of the sesquiterpene alcohol having a sedrene skeleton is 0.06 to 6% by weight. 6. The content of the sesquiterpene alcohol having an aromadendrene skeleton is 0.001 to 5% by weight.
The oral composition according to claim 4, which is: