JPS62198611A - Composition for oral cavity application - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity application having improved taste such as acidulant taste and astringent taste and giving improved feeling to the palate, by adding a specific perfume component to an oral cavity composition containing an organic acid and/or its salt. CONSTITUTION:A composition for oral cavity application containing an organic acid (e.g. phytic acid, ethylenediaminetetraacetic acid, citric acid, tartaric acid, malonic acid, L-ascorbic acid, etc.) and/or its salt and optionally other drug component (e.g. stannous compound such as stannous fluoride) is compounded with one or more kinds of perfume components selected from 1-500ppm of oleoresin (e.g. cayenne-pepper, pepper, sage, etc.), 0.1-100ppm of concrete (e.g. iris concrete), 2-500ppm of sesquiterpene (e.g. caliofilen, sedolor, etc.), 40-4,000ppm of cineole, natural essential oil (e.g. eucalyptus oil, laurel oil, etc.) containing 20-3,000ppm of cineole, 0.1-300ppm of vaniline and 1-200ppm of spilanthol.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition containing an organic acid, and more specifically, by blending a specific flavoring ingredient, it is possible to improve acidity, astringency, etc. The present invention relates to an oral composition with improved taste and feeling of use.

Conventionally, stannous fluoride was combined as a medicinal ingredient, and phytic acid, citric acid, or their salts were used as stabilizers for stannous fluoride. Oral compositions containing organic acids are known (Japanese Unexamined Patent Publication No. 56-45407, etc.), and oral compositions containing tannic acid as an anti-hemostasis agent and various organic acids as stabilizers ( Japanese Patent Publication No. 55-69508
Also known are toothpastes containing polycarboxylic acids such as citric acid as stabilizers (Japanese Unexamined Patent Publication No. 129215/1983).

However, organic acids blended into oral compositions exhibit acidity and astringency, which adversely affect palatability.

In order to improve such poor palatability, it is conceivable to add a sweetener, but according to the studies conducted by the present inventors,
Adding sweeteners does not improve acidity or astringency. Also,
Conventionally, even if peppermint-based, spearmint-based flavorings, anethole, and the like, which are commonly used in oral compositions such as toothpastes, are added, acidity and astringency are not similarly improved.

Therefore, it is desired to improve the feel of oral compositions containing organic acids.

The present invention was made in view of the above circumstances, and an object of the present invention is to remove the sour taste and astringency of an oral composition containing organic acids such as phytic acid, and to provide an oral composition with excellent taste. shall be.

As a result of intensive research to achieve the above object, the present inventors have developed an oral composition containing organic acids such as phytic acid, especially fluoride as a medicinal ingredient. For oral compositions containing a stannous compound such as stannous tin and an organic acid as a stabilizer thereof, certain fragrance ingredients, such as oleoresins, concretes, sesquiterpenes, cineole, and natural substances containing cineole, are used. The present invention was made based on the discovery that when essential oils, vanillin, and spilanthols are blended alone or in combination, the sourness and astringency of oral compositions are improved and excellent taste is exhibited. It is.

Therefore, the present invention contains an organic acid and/or a salt thereof,
In an oral composition containing a medicinal ingredient such as a stannous compound if necessary, the flavoring ingredient is selected from oleoresins, concretes, sesquiterpenes, cineole, natural essential oils containing cineole, vanillin, and spiran-1-hales. Provided is an oral composition characterized in that it contains one or more of the following.

The present invention will be explained in more detail below.

As described above, the present invention provides an oral composition containing organic acids, in particular, a composition containing a stannous compound such as stannous fluoride as a medicinal ingredient for strengthening teeth, and an organic acid as a stabilizer thereof. This is an oral composition containing a specific fragrance ingredient.

Here, when a stannous compound is blended into the oral composition of the present invention, examples of the stannous compound include stannous fluoride, stannous pyrophosphate, etc., and one or two of these compounds may be used. The above can be blended. In addition, when blending stannous fluoride, the blending amount is preferably 0.05 to 0.4% (weight %, same hereinafter), particularly 0.25 to 0.4% of the entire composition. .

There are no particular restrictions on the organic acids, but when a stannous tin compound is added, those that are effective in stabilizing tin due to metal chelating action are preferably used; examples include phytic acid, ethylenediaminetetraacetic acid. (EDTA),
One or more selected from citric acid, tartaric acid, malonic acid, L-ascorbic acid, and salts thereof can be mentioned.

Its blending amount is 0.01 to 5% of the total composition, especially 0.5%.
~3% is preferred.

In addition to the above-mentioned organic acids, the present invention blends specific fragrance ingredients, namely oleoresins, concretes, sesquiterpenes, cineole, natural essential oils containing cineole, vanillins, and spilanthols. This is an oral composition containing acids with improved taste.

Here, the oleoresins used as fragrance ingredients include chili pepper, ginger, and pepper.

One or two selected from oleoresins of sage, cardamom, pimento berry, celery seed, and nutmeg
It is preferable that more than one species is used effectively, and the amount thereof is 1 to 500 ppm, particularly 5 to 1,100 ppm based on the total composition. In addition, Iris concrete is preferable as the concrete type, and its blending amount is O, 1 of the entire composition.
It is preferable to set it to 1100 ppm, especially 2 to 20 PPm. Furthermore, as the sesquiterpenes, one or more selected from caryophyllene, cedrol, cedrene, and caryophyllene alcohol are suitable. The blending amount is 2 to 500 ppm, especially 10 to 50 ppm of the entire composition.
It is preferable to use PPm.

In addition, examples of fragrance components include cineole and essential oils containing cineole, and the cineole-containing essential oil is preferably one or more selected from eucalyptus oil, laurel oil, rosemary oil, and sage oil. In the case of cineole, the blending amount is 40 to 400% of the total composition.
0 ppm, especially 500-2000 ppm, in the case of essential oils containing cineole, 20-3000 ppm of the total composition.
ppm, particularly preferably 100 to 11000 ppm. Furthermore, as the vanillin, vanillin and/or ethylvanillin are preferably used.

The blending amount is 0.1 to 300 ppm of the entire composition.

In particular, it is preferably 0.4 to 10 pPm.

As the spilanthols, spilanthol, oleoresin containing spilanthol, and natural essential oils containing spilanthol such as baracles oil are preferably used, and among these, oleoresin containing baracres oil is preferred. Its blending amount is 1 to 200% of the total composition.
It is preferable to set it as ppm, especially 2-50PPm.

In addition, the above-mentioned oleoresins, concretes, sesquiterpenes, cineole, essential oils containing cineole, vanillins, and spilanthols can suppress the sourness and astringency of organic acids even when used alone, but
By using two or more types in combination, the effect is further exhibited, and the taste of the oral composition is further improved, giving it a round, sweet taste.

In addition, vanillins react with metal ions in the composition and cause coloration or discoloration, but in the present invention, by blending organic acids, coloring or discoloration of the composition does not occur even if a large amount of vanillin is blended. Therefore, it does not cause any problems with wanirin.
It also has the advantage that it can be used without any restrictions on the amount of compounding.

The oral composition of the present invention includes dentifrices such as toothpaste, moisturized toothpaste, and liquid toothpaste, mouthwash, troche, chewing gum, oral pasta, gum pine surge cream, other liquid mouth fresheners, and solid mouth fresheners. However, as other components of the present invention, appropriate components commonly used may be blended depending on the type of oral composition, purpose of use, etc.

For example, in the case of toothpaste, dibasic calcium phosphate
Hydrates and anhydrides, monocalcium phosphate, tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate,
Silica-based abrasives such as titanium oxide, alumina, hydrated alumina, silica gel, colloidal silica, and anhydrous alkali metal silicate complexes.

One or more synthetic resins such as aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, silicic acid, zirconium, polymethyl methacrylate, etc. Can be blended (compounding amount usually 2
0% to 90%, 20% to 60% in case of toothpaste).

In addition, in the case of paste-form oral compositions such as toothpaste, carrageenan and carboxymethylcellulose sodium! Cellulose derivatives such as methylcellulose, hydroxyethylcellulose, and sodium carboxymethylhydroxyethylcellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, gum tragacanth, gum karaya, and gum arabic, polyvinyl alcohol, and sodium polyacrylate. , carboxyvinyl polymers, synthetic binders such as polyvinylpyrrolidone, and silica gel.

One or more inorganic binders such as aluminum silica gel, Veegum, Laponite, etc. may be blended (the blending amount is usually 0.3 to 5%).

Furthermore, in the production of dentifrices and other oral compositions,
As a thickening agent, one or more of sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltit, laftit, etc. may be blended (the amount usually ranges from 10 to 70%).

In addition, as a surfactant, sodium lauryl sulfate, sodium myristyl sulfate, etc. with an alkyl group of 8 to 1 carbon atoms are used.
Water-soluble salts of higher alkyl sulfates such as No. 8, water-soluble higher fatty acid monoglyceride monosulfates such as hydrogenated coconut oil fatty acid monoglyceride sodium monosulfate, alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, higher alkyl sulfonic acids salt, higher fatty acid ester of 1,2-dihydroxypropanesulfonate,
anionic activators such as substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds such as the sodium, potassium or ethanolamine salts of N-lauroyl, N-myristoyl or N-balmitoyl sarcosine, sucrose; Sucrose fatty acid esters, lactose fatty acid esters, lactitol fatty acid esters, maltitol fatty acid esters, stearic acid monoglycerides, in which the fatty acid group has 12 to 18 carbon atoms such as mono- and dilaurate;
Polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene (10,20°40.60,80,100 mol), hydrogenated castor oil, polymer of ethylene oxide and propylene oxide, and polyoxyethylene poly One or more types of nonionic active agents such as condensation products of polyethylene oxide such as oxypropylene monolauryl ester and fatty acids, fatty alcohols, polyhydric alcohols, and polypropylene oxide, and amphoteric active agents such as betaine type and amino acid type. Surfactant (compounding amount usually 0~7%)
, preferably 0.3 to 5%).

The oral composition of the present invention further contains saccharin sodium, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanine methyl ester, P-methoxycinnamic aldehyde, sucrose, lactose, fructose, saccharin sodium, etc. Sweetener (0-1%, preferably 0
．． 01-0.5%), and further p-hydroxymethyl benzoic acid, p-hydroxyethyl benzoic acid, p-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, sodium benzoate, lower fatty acid monoglyceride if necessary. Appropriate amounts of preservatives such as these may be added.

Also, in addition to the above fragrance ingredients, peppermint oil.

Spearmint oil, clove oil, cinnamic, orange oil, cassia oil, cardamom oil, lemon oil, neroli oil, lavender oil, 11-menthol, Ω-carvone, anethole, dodecylaldehyde, angelica root oil, isoamyl acetate, ethyl butyrate, Methyl cellulose
essential oils and fragrance materials such as (O,OOI~2%, preferably 0.5~1.5%), whitening agents such as gelatin, peptone, arginine hydrochloride, albumin, casein, titanium dioxide, Silicone, pigments, various active ingredients, etc. can be blended, and for example, in the case of toothpaste, it can be manufactured by mixing the above-mentioned desired ingredients with water from the office.

Moreover, when producing other oral compositions, they can be produced according to conventional methods using appropriate commonly used ingredients.

As explained above, the oral composition according to the present invention improves the sourness and astringency of the organic acids by blending a specific fragrance ingredient into the oral composition containing organic acids. can be removed, and will not cause coloring or discoloration even when vanillin is used. Therefore, in the oral composition of the present invention, flavor components can be freely combined and blended, and a desired flavor can be imparted.

EXAMPLES Next, the present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples. Incidentally, Table 1 shows the fragrance composition formulations blended into the toothpastes of Examples and Comparative Examples.

Table 1 (The amounts of the above raw material components are in parts by weight) [Example 1.
Comparative Examples 1 and 2] Toothpastes having the formulations shown in Table 2 were prepared, and 13 expert panels conducted a sensory test for masking degree of sourness, astringency, and palatability. The results are shown in Table 3.

Table 2 (Toothpaste Prescription) Table 3 From the results shown in Table 3, the toothpaste of Example 1 had less acidity and astringency than the toothpaste of Comparative Example 1, and also had better palatability (sweet taste). It is found that this is high.

In addition, the toothpastes with the formulations shown in Table 2 were stored for 3 months at temperatures of -5°C, room temperature, 40''C, and 50'C, respectively, and the degree of coloration was examined.The results are shown in Table 4.

Table 4 -: No coloring ±: Slightly colored +: Colored ++: Colored Colored 10: Colored considerably However, it is found that the toothpaste of Example 1, in which vanillin and pentasodium phytate were used in combination, significantly suppresses the coloring caused by vanillin.

[Example 2, 3. Comparative Example 3] Toothpastes having the formulations shown in Table 5 were prepared, and the masking degree of sourness, astringency, and palatability were sensory tested in the same manner as in Example 1. The results are shown in Table 6.

Table 5 (Toothpaste Prescription) Table 6 From the results shown in Table 6, the toothpastes of Examples 2 and 3 suppressed the sourness and astringency caused by pentasodium phytic acid salt compared to the toothpaste of Comparative Example 3, and It is also found that palatability is excellent.

[Example 4, 5. Comparative Example 4 A toothpaste having the formulation shown in Table 7 was prepared, and 17 expert panels conducted a sensory test for masking degree of acidity, astringency, and palatability. The results are shown in Table 8.

Table 7 (Toothpaste Prescription) Table 8 From the results shown in Table 8, the toothpastes of Examples 4 and 5 suppressed the acidity and astringency caused by pentasodium phytate salt to a lower level than the toothpaste of Comparative Example 4, and It is also found that palatability is excellent.

[Examples 6 and 7, Comparative Example 5] Toothpastes having the formulations shown in Table 9 were prepared, and the masking degree of sourness, astringency, and palatability were sensory tested in the same manner as in Example 4.5. The results are shown in Table 10.

Table 9 (Toothpaste Prescription) Table 10 From the results shown in Table 10, the toothpastes of Examples 6 and 7 suppressed the acidity and astringency caused by pentasodium phytate salt to a lower level than the toothpaste of Comparative Example 5, and It is also found that palatability is excellent.

Claims (1)

[Scope of Claims] 1. An oral composition containing an organic acid and/or a salt thereof, and optionally a medicinal ingredient, which contains oleoresins, concretes, sesquiterpenes, as fragrance ingredients;
An oral composition comprising one or more selected from cineole, a natural essential oil containing cineole, vanillins, and spilanthols. 2. The oral composition according to claim 1, which contains a stannous compound as a medicinal ingredient. 3. Organic acids such as phytic acid, ethylenediaminetetraacetic acid, citric acid, tartaric acid, malonic acid, L-ascorbic acid,
The oral composition according to claim 1 or 2, which uses one or more selected from the group consisting of: and salts thereof. 4. Claims 1 to 3 in which one or more oleoresins selected from chili pepper, ginger, pepper, sage, cardamom, pimento berry, celery sheet, and nutmeg oleoresins are used as oleoresins.
The composition for oral cavity according to any one of the above. 5. The composition for oral cavity according to any one of claims 1 to 3, which uses iris concrete as the concrete. 6. The oral composition according to any one of claims 1 to 3, which uses one or more selected from caryophyllene, cedrol, cedrene, and caryophyllene alcohol as the sesquiterpenes. 7. Eucalyptus oil as a natural essential oil containing cineole,
The oral composition according to any one of claims 1 to 3, which uses one or more selected from laurel oil, rosemary oil, and sage oil. 8. The composition for oral cavity according to any one of claims 1 to 3, which uses vanillin and/or ethyl vanillin as the vanillin. 9. The method according to any one of claims 1 to 3, in which one or more types selected from spilanthol, oleoresin containing spilanthol, and natural essential oil containing spilanthol are used as the spilanthols. Oral composition.