JPH10152424A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition, capable of raising the blood flow rate by excellent massaging effects and excellent in preventing and therapeutic effects on periodontosis by including a granular common salt having a specific average grain diameter in a specific proportion therein. SOLUTION: This composition is obtained by formulating (A) 3-15wt.% granular common salt having 700-1,400μm, preferably 800-1,200μm average grain diameter with, as necessary, (B) 5-30wt.% sodium bicarbonate having 30-500μm average particle diameter, granular common salt having the grain diameter other than that in the ingredient A, 15-40wt.% common salt in the form other than that in the ingredient A such as a solutionlike common salt, a humectant, a binder, a dentine reinforcing agent, a germicide, enzymes, an antiinflammatory agent, a blood circulation promoter, a surfactant, a sweetener, a colorant, coloring matters, a perfume, etc. The resultant composition can be used as, e.g. a toothpaste, a tooth powder or a gingival local liniment.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition which can enhance blood flow by an excellent massage effect and is excellent in the effect of preventing and treating periodontal disease.

[0002]

2. Description of the Related Art Periodontal disease is one of the two major diseases in the oral region along with caries. In particular, alveolar pyorrhea is a serious problem in today's aging society.
Therefore, its prevention and treatment have a very important meaning in oral hygiene, and toothpastes using salt as a medicinal agent for these purposes are commercially available. It is said that the action of this salt is to improve tissue circulation in local gingiva by absorbing tissue fluid in inflamed gingiva. But,
When a high concentration of sodium chloride is added for the purpose of enhancing the effect of the salt, there is a disadvantage that the saltiness becomes strong and the palatability as an oral composition is significantly impaired. Therefore, saltiness is reduced by blending an undissolved granular salt having a large particle diameter into the oral composition (Japanese Patent Publication No. 3-2122). Conventionally, granular salt having an average particle size of about 300 to 500 μm has been used to reduce saltiness.

[0003] However, in the oral composition containing such a granular salt, although the effect of the salt as a medicinal agent can be obtained, a sufficient blood flow promoting effect cannot be obtained.

[0004]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide an oral composition which has a high blood flow promoting effect and is excellent in the prevention and treatment of periodontal disease.

[0005]

Under such circumstances, the present inventors have conducted intensive studies and as a result, it has been found that the use of granular salt having a specific particle size can increase the blood flow rate due to an excellent massage effect, and to increase the periodontal periodontal. The present inventors have found that an oral composition excellent in the effects of preventing and treating diseases can be obtained, and have completed the present invention.

That is, the present invention provides a composition comprising:
It is intended to provide an oral composition containing 3 to 15% by weight of granular salt having an average particle size of 700 to 1400 µm.

[0007]

DETAILED DESCRIPTION OF THE INVENTION The granular salt used in the present invention is:
The average particle size in the composition is 700 to 1400 μm, preferably 700
12001200 μm, particularly preferably 800-1200 μm. If the average particle diameter is less than 700 μm, the particle diameter is small, so that a sufficient massage effect cannot be obtained.If the average particle diameter is more than 1,400 μm, the number of particles per unit weight decreases, and the number of times of contact with the gingiva decreases. A good massage effect cannot be obtained.

[0008] Such a granular salt may have an average particle diameter in the above-mentioned range, but it is preferable that particles having a diameter of 700 µm or more account for 30% or more, particularly 40% or more of the whole. Further, it is more preferable that particles having an average particle diameter of 750 to 900 μm be 50% or more, particularly 70% or more of the whole in terms of feeling in the mouth.

In the present invention, granular salt is contained in the composition at 3%.
-15% by weight, preferably 3-12% by weight, particularly preferably 5-10% by weight. If it is less than 3% by weight, a sufficient massage effect cannot be obtained, and if it exceeds 15% by weight,
The feel and taste during use are very poor. In addition, the granular salt is dissolved during the production to reduce the particle size, or the content of the salt having the particle size decreases, so that the average particle size and the content in the composition obtained after the production are reduced. It is preferable to use a granular salt having a compounding amount larger than a desired amount in the composition in advance so as to be in the above range.

The oral composition of the present invention further comprises an average particle size.
Baking soda having a particle size of 30 to 500 µm, particularly preferably 80 to 250 µm, can be blended, and the particles can further enhance the massage feeling. Such baking soda has 5 to 30 parts in the total composition.
% By weight, and more preferably 10 to 20% by weight, because the massage feeling can be further improved.

The composition for oral cavity of the present invention comprises a salt in a form other than the above-mentioned granular salt, for example, a granular salt having a particle size other than the above,
A solution salt or the like can be contained at an arbitrary ratio. The content of the entire salt is preferably 15% by weight or more in the composition of the present invention, and the upper limit is not particularly limited. However, considering the practical shape and form of the composition for oral cavity, it is about About 40% by weight is preferred.

The oral composition of the present invention can be produced by a conventional method, and can be made into a dosage form usually used as an oral composition, for example, toothpaste, powdered toothpaste, topical gingival preparation and the like. it can.

Various known components can be used in the oral composition of the present invention depending on the form and the like. For example, glycerin, sorbit, propylene glycol, 1,3-
Wetting agents such as butylene glycol, ethylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactit; carboxymethylcellulose and salts thereof, methylcellulose, hydroxyethylcellulose, carrageenan, sodium polyacrylate, hydroxypropylcellulose, sodium carboxymethylhydroxyethylcellulose, Binders such as sodium alginate, propylene glycol alginate, xanthan gum, gum tragacanth, gum karaya, gum arabic, polyvinyl alcohol, polyvinylpyrrolidone, veegum, laponite; tooth toughening such as sodium monofluorophosphate, tin fluoride, sodium fluoride Agents: Chlorhexidine salts, cetylpyridinium chloride, etc. pH such as sodium phosphate; fungicides
Regulators; enzymes such as dextranase, amylase, protease, lysozyme, and mutanase; hinokitiol, ε-aminocaproic acid, tranexamic acid, allantoins, tocopherols, dihydrocholesterol,
Glycyrrhetinic acid, glycyrrhizic acid and its salts, glycerophosphate, chlorophyll, water-soluble inorganic phosphate compounds, azulene, chamomile, Toki, Kawaumi, herbal medicines and other anti-inflammatory agents and blood circulation promoters; lauryl sulfate, myristyl sulfate , Α-olefin sulfonate, N-acyl amino acid salt, acyl monoglyceride sulfate, soap, fatty acid monoglyceride, fatty acid monoalkanolamide, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, alkyl glycoside, imidazolinium betaine Surfactants such as sodium, alkylbetaine, alkylamidobetaine, sulfobetaine, and amine oxide; sweeteners such as saccharin sodium, stevioside, thaumatin, and asparatylphenylalanine methyl ester; Carboxy - benzoic acid, p- hydroxy -
Ethyl benzoate, p-hydroxy-propyl benzoate,
Preservatives such as p-hydroxy-butyl benzoate and sodium benzoate; coloring agents and pigments such as titanium dioxide; peppermint oil, spearmint oil, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl Alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, crocodile, thymol, anise oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil , Laurel oil, perilla oil, winter green oil,
Flavors such as clove oil, eucalyptus oil and the like can be appropriately used as long as the effects of the present invention are not impaired.

[0014]

EFFECT OF THE INVENTION The oral composition of the present invention can enhance blood flow by an excellent massage effect, and is excellent in prevention and treatment of periodontal disease. In addition, since salt having a larger particle size is blended than the granular salt used in the conventional oral composition, the saltiness is reduced and the taste is good, and since the particle size is large and the surface area is small, it is difficult to dissolve. , The feeling of massage lasts.

[0015]

EXAMPLES The present invention will be further described with reference to the following examples, but the present invention is not limited thereto. The average particle size of the granular salt is measured according to JIS Z8.
The test was carried out using a standard sieve for 801-1994 test.

Example 1 Toothpaste compositions were prepared by a conventional method using the components having the compositions shown in Table 1, and the effect of promoting blood flow when these compositions were used was evaluated. The results are shown in FIG. In addition, the content of the granular salt in the obtained composition was in the range of 3 to 15% by weight.

[0017]

[Table 1]

(Evaluation method) Six males with gingival inflammation were taken as subjects, and blood flow was measured for 3 to 3 maxillary teeth when brushing with a round-cut toothbrush (8/1000) and 1 g of toothpaste. . For the measurement, the subject was laid on his / her back, brushed for 1 minute with the surgeon's polish while holding the angle weider, and then the blood flow was measured by the laser Doppler method every 5 minutes. The results were the relative blood flow before brushing, and were shown as the average value of 6 subjects.

As is apparent from the results shown in FIG.
When the product of the present invention containing 1000 μm of granular salt was used, the blood flow rate was higher than that of the comparative product containing granular salt of 350 μm in average particle size.

Example 2 An oral composition was prepared by a conventional method using the following components. In the obtained composition, the content of granular salt (average particle size: 1000 μm) was in the range of 3 to 15% by weight. The resulting composition was excellent in terms of massage effect and taste.

[0021]

(Components) (% by weight) Granular salt (average particle size: 1000 μm) 16.00 Sorbitol 14.00 Purified glycerin 7.00 Carrageenan 0.60 Carboxymethylcellulose 0.60 Silica 2.01 Saccharin sodium 0.03 Hydroxide Aluminum 38.70 Sodium alkyl sulfate 2.00 Fragrance 0.80 Sodium hydroxide (48%) 0.21 Purified water Balance 100.00

[Brief description of the drawings]

FIG. 1 is a graph showing changes in blood flow when brushing is performed using a toothpaste composition in Example 1.

Claims (1)

[Claims] 1. The composition has an average particle size of 700 to 140.
An oral composition containing 3 to 15% by weight of 0 μm granular salt.