JP2021054765A - Oral composition - Google Patents

Abstract

To give a refreshing feel in the mouth while obtaining a relaxing effect.SOLUTION: An oral composition contains component A: a mint flavor, component B: at least one selected from limonene and linalool, and component C: an acetate ester compound. The component A is contained by 0.01-0.6 mass%; of the component B, limonene is contained by 0.01 mass% or more and/or linalool is contained by 0.001 mass% or more; and the component C is contained by 0.001 mass% or more.SELECTED DRAWING: None

Description

The present invention relates to an oral composition having a relaxing effect while giving a refreshing feeling in the mouth.

Patent Document 1 describes an oral composition. It contains 0.1 to 1.0% by mass of menthol, which is a mint-based fragrance, and 0.001 to 0.4% by mass of linalool.

JP-A-2018-104377

Since the oral composition of Patent Document 1 contains a relatively large amount of menthol, which is a mint-based fragrance, a refreshing feeling in the mouth can be obtained, but the awakening effect of menthol provides sedation before going to bed. It has a problem that it may not be suitable for use in a desired state.

The present invention has been made in view of such circumstances, and an object of the present invention is to provide an oral composition having a relaxing effect while giving a refreshing feeling in the mouth.

An oral composition for solving the above problems is an oral composition containing A component: a mint-based fragrance, B component: limonene, at least one selected from linalool, and C component: an acetate ester compound. In the composition for use, the A component is 0.01 to 0.6% by mass, the limonene is 0.01% by mass or more, and / or the linalool is 0.001% by mass or more among the B components. , The C component is contained in an amount of 0.001% by mass or more.

With respect to the oral composition, it is preferable that the mint-based fragrance is at least two or more selected from menthol, menthone, and isomenthone.
For the oral composition, the acetic acid ester compound is preferably at least one selected from ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, hexenyl acetate, benzyl acetate, linaryl acetate and geranyl acetate.

The oral composition preferably contains the limonene as the B component.
The oral composition is preferably composed in a liquid state.

According to the oral composition of the present invention, a relaxing effect can be obtained while giving a refreshing feeling in the mouth.

Hereinafter, an embodiment in which the oral composition of the present invention is embodied will be described.
The oral composition of the present embodiment contains a component A: a mint-based fragrance, a component B: limonene, and at least one selected from linalool, and a component C: an acetic acid ester compound.

The mint-based fragrance as the component A is not particularly limited, and mint-based natural fragrances and synthetic fragrances can be used. Specific examples of the components of the mint-based fragrance include menthol, menthol, isomenthol, eucalyptol, pulegone, mentholacetate and the like. Among them, it is preferable to contain at least two kinds selected from menthol, menthone and isomenthone.

The component A is contained in the oral composition in an amount of 0.01 to 0.6% by mass. The component A is preferably contained in the oral composition in an amount of 0.01 to 0.1% by mass, more preferably 0.01 to 0.06% by mass. By defining the content of component A in such a range, a refreshing feeling in the mouth can be obtained. The content of each component in the oral composition indicates the content in the oral composition including a solvent such as water. Further, in the present specification, when the numerical range is represented by using "~", the numerical values at both ends thereof are included.

When limonene is contained as the B component, it is contained in an oral composition in an amount of 0.01% by mass or more. Limonene is preferably contained in the oral composition in an amount of 0.01 to 0.1% by mass, more preferably 0.01 to 0.05% by mass.

When linalool is contained as the B component, it is contained in an oral composition in an amount of 0.001% by mass or more. Linalool is preferably contained in the oral composition in an amount of 0.001 to 0.05% by mass, more preferably 0.001 to 0.005% by mass.

By defining the content of the B component in such a range, a relaxing effect can be obtained without deteriorating the refreshing feeling in the mouth and the palatability of the flavor.
Specific examples of the acetic acid ester compound as the C component are not particularly limited, and examples thereof include ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, hexenyl acetate, benzyl acetate, linaryl acetate, and geranyl acetate. Can be done. Among them, it is preferable to contain at least one selected from hexenyl acetate, isoamyl acetate, linalyl acetate and benzyl acetate.

The C component is contained in the oral composition in an amount of 0.001% by mass or more. The component C is preferably contained in the oral composition in an amount of 0.001 to 0.01% by mass, more preferably 0.001 to 0.005% by mass.

By defining the content of the C component in such a range, a relaxing effect can be obtained without deteriorating the refreshing feeling in the mouth and the palatability of the flavor.
The application form of the oral composition is not particularly limited, and can be used as, for example, pharmaceuticals, quasi-drugs, and cosmetics. As the use of the oral composition, known ones can be appropriately adopted, for example, denture polish, mouthwash, rinsing agent, liquid toothpaste, biofilm dispersant, mouth odor preventive agent, gum massage agent, etc. Oral moisturizer, tongue moss remover, oral coating agent, oral sterilizer, throat sterilizer, oropharyngeal agent, periodontal disease treatment agent, denture wearing agent, denture coating agent, denture stabilizer, denture preservative, Examples include denture cleaning agents and implant care agents.

The dosage form of the oral composition is not particularly limited, and for example, by containing a solvent such as water or alcohol, an ointment, a paste, a pasta, a spray, a gel, a liquid, a suspension / emulsifier, or a gum It can be applied to agents and the like.

The type of water used as the solvent is not particularly limited, and for example, distilled water, pure water, ultrapure water, purified water, tap water, or the like can be used. The type of alcohol used as the solvent is not particularly limited, and for example, ethanol can be used. Water and alcohol can be mixed and used.

When the oral composition is composed of a liquid, the content of the solvent such as water is preferably 60 to 99.8% by mass, more preferably 70 to 90% by mass.
The oral composition has components other than the above-mentioned components, such as antibacterial agents, anti-inflammatory agents, fragrances, wetting agents, surfactants, abrasives, alcohols, and thickeners, depending on the purpose of application, form, application, and the like. , Sweetness component, medicinal component, colorant, stabilizer, pH adjuster and the like may be blended. As each of these components, known ones to be blended in the oral composition can be used. Only one type of each of these components may be applied, or two or more types may be applied in combination.

Specific examples of the antibacterial agent include cetylpyridinium chloride, paraben, sodium benzoate, triclosan, chlorhexidine hydrochloride, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, hinokithiol and the like.

Specific examples of the anti-inflammatory agent include glycyrrhizate, tranexamic acid, ε-aminocaproic acid, Phellodendron amur extract and the like.
Specific examples of the fragrance include anethole, eugenol, carboxylic, winter green, methyl salicylate, thymol, clove oil, sage oil, osimene oil, citronellol and the like.

Specific examples of the wetting agent include polyhydric alcohols such as sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, and polyethylene glycol.

Specific examples of the surfactant include nonionic surfactants, anionic surfactants, and amphoteric surfactants.
Specific examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester and maltose fatty acid ester, sugar alcohol fatty acid esters such as multitoll fatty acid ester, sorbitan fatty acid ester such as sorbitan monolaurate, and polyoxyethylene. Polyoxyethylene sorbitan fatty acid esters such as sorbitan monolaurate and polyoxyethylene sorbitan monostearate, fatty acid alkanolamides such as laurate diethanolamide, polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether and polyoxyethylene oleyl ether, Polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, alkyl glucosides such as lauryl glucoside and decyl glucoside, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, poly Examples thereof include oxyethylene hydrogenated castor oil, glycerin fatty acid ester, and polyoxyethylene propylene block copolymer.

Specific examples of the anionic surfactant include sulfate esters such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate, sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate, and sodium cocoyl sarcosin. , Acrylic amino acid salts such as sodium lauroylmethylalanine, sodium cocoylmethyltaurine and the like.

Specific examples of amphoteric tensides include amino acid amphoteric tensides such as N-lauryldiaminoethylglycine and N-myristyldiethylglycine, alkyldimethylaminoacetate betaine, and N-alkyl-N'-carboxymethyl-N'. Examples thereof include −hydroxyethylethylenediamine salt and betaine amphoteric surfactants such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

Specific examples of the abrasive include calcium carbonate, magnesium carbonate, calcium dibasic phosphate, calcium tribasic phosphate, magnesium phosphate, silica, zeolite, sodium metaphosphate, aluminum hydroxide, magnesium hydroxide, calcium pyrophosphate, red iron oxide, calcium sulfate. , Calcium anhydride and the like.

Specific examples of alcohols include ethyl alcohol, lauryl alcohol, myristyl alcohol and the like.
Specific examples of the thickener include sodium polyacrylate, carrageenan, sodium carboxymethyl cellulose, sodium alginate, xanthan gum, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, propylene glycol alginate and the like.

Specific examples of the sweetening component include saccharin, sodium saccharin, sucralose, stebioside, acesulfame potassium, aspartame, xylitol, maltitol, erythritol, cycloheptaamylose and the like.

Specific examples of medicinal ingredients include fluorides such as sodium monofluorophosphate, sodium fluoride, stannous fluoride and strontium chloride, condensed phosphates such as sodium pyrophosphate and sodium polyphosphate, and monophosphate. Phosphates such as sodium hydrogen hydrogen and trisodium phosphate, vitamins such as ascorbic acid, sodium ascorbate, pyridoxin hydrochloride, tocopherol acetate, glucanase enzymes such as dextranase and mutanase, degrading enzymes such as protease and lysoteam, chloride Examples thereof include inorganic salts such as zinc, zinc citrate, strontium chloride and potassium nitrate, chelating compounds such as chlorophyll and glycerophosphate, polyethylene glycol which dissolves fat, sodium chloride, aluminum lactate and strontium chloride.

Specific examples of the colorant include legal dyes such as Green No. 1, Blue No. 1, and Yellow No. 4, titanium oxide, and the like.
Specific examples of the stabilizer include sodium edetate, sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate and the like.

Specific examples of the pH adjuster include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphate, glycerophosphate, various salts such as potassium salt, sodium salt and ammonium salt thereof, and sodium hydroxide. And so on. The oral composition is preferably adjusted so that the pH is in the range of 4 to 9, particularly 5 to 7, by blending a pH adjusting agent.

The effect of the oral composition of the present embodiment will be described.
(1) The oral composition of the present embodiment contains A component: a mint-based fragrance, B component: limonene, at least one selected from linalool, and C component: an acetic acid ester compound. A component is 0.01 to 0.6% by mass, limonene is 0.01% by mass or more, and / or linalool is 0.001% by mass or more, and C component is 0.001% by mass or more. To do. By containing the component A in the above numerical range, a refreshing feeling in the mouth can be given. Further, by containing the B component and the C component in the above numerical range, a relaxing effect can be obtained without deteriorating the refreshing feeling in the mouth and the palatability of the flavor. Therefore, it is possible to obtain an oral composition suitable for use in a state where sedation is desired, such as before going to bed.

(2) At least two or more mint-based fragrances are selected from menthol, menthone, and isomenthon. Therefore, the refreshing feeling in the mouth due to the component A becomes more preferable.

(3) The acetic acid ester compound is at least one selected from ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, hexenyl acetate, benzyl acetate, linaryl acetate and geranyl acetate. Therefore, the relaxing effect of the C component becomes more preferable.

(4) Contains limonene as component B. Therefore, the relaxing effect of the B component becomes more preferable.
(5) The oral composition is composed of a liquid. Therefore, the effect can be obtained in a shorter time after the oral composition is applied into the oral cavity, as compared with the embodiment in which the oral composition is formed in a solid state.

This embodiment can be modified and implemented as follows. The present embodiment and the following modified examples can be implemented in combination with each other within a technically consistent range.
-In the above embodiment, the above-mentioned A component, B component, and C component may be blended in the oral composition at the time of use, and may be divided into a plurality of agents at the time of storage. Further, the oral composition may be stored as a solid agent such as powder, and may be made liquid by adding a solvent such as water at the time of use. Even in such a configuration, a relaxing effect can be obtained while giving a refreshing feeling in the mouth.

The oral composition of the present invention will be described in more detail based on the following test examples. The present invention is not limited to the configuration described in the Example column.
The oral compositions of Examples 1 and 2 and Comparative Examples 1 and 2 shown in Table 1 were produced by mixing and stirring each component according to a conventional method. As the fragrance in the other components of the oral composition, those containing almost no A component, B component, and C component were used. Here, it is assumed that "things that are hardly contained" include not only those that are not contained at all but also those that are contained at an impurity level. The oral composition produced was liquid. In Table 1, the numerical value shown on the right side of each component means the content (mass%) in the oral composition.

(Evaluation test)
The oral compositions of Examples 1 and 2 and Comparative Examples 1 and 2 were subjected to a sensory evaluation of the refreshing feeling in the mouth and the taste of flavor. In addition, the skin electrical reaction (hereinafter, also referred to as "GSR") was measured for the relaxing effect. GSR is a general term for the potential activity observed in the skin and the impedance fluctuation associated with sweating. When the sympathetic nerve becomes active due to psychological agitation such as tension, stress, and anxiety, sweating occurs in the peripheral. GSR is used as an index of the sympathetic nerve of the peripheral autonomic nervous system by attaching electrodes to the fingertips and palms that easily reflect such mental sweating and measuring them.

(Sensory evaluation of refreshing feeling)
The sensory evaluation of the feeling of cleanliness was performed by 10 monitors. The oral composition prepared in each Example and each Comparative Example was contained in a 10 ml mouthwash as a mouthwash, and the mouth was washed for 20 seconds. After the mouthwash was spit out, the feeling of cleanliness in the mouth was evaluated using the following evaluation criteria using a visual evaluation scale (hereinafter, also referred to as "VAS").

(Evaluation criteria)
The left end of the straight line was "not felt at all" and the right end of the straight line was "very felt", and the evaluation was made by marking arbitrary positions according to the felt intensity. The left end of the straight line was set to 0 points, the right end of the straight line was set to 100 points, and the score was calculated from the distance from the left end side of the straight line. The values of sensory evaluation by 10 monitors were totaled to calculate the average value. As shown below, it was assumed that good results were obtained when the average value was 60 points or more. The results are shown in Table 1.

⊚: 80 points or more ○: 60 points or more and less than 80 points Δ: 40 points or more and less than 60 points ×: less than 40 points (sensory evaluation of flavor preference)
The sensory evaluation of the taste of flavor was performed in the same manner as the sensory evaluation of the refreshing feeling, and was performed at the same time as the sensory evaluation of the refreshing feeling. The taste of flavor was evaluated using VAS according to the following evaluation criteria.

(Evaluation criteria)
The left end of the straight line was "disliked" and the right end of the straight line was "liked". The left end of the straight line was set to 0 points, the right end of the straight line was set to 100 points, and the score was calculated from the distance from the left end side of the straight line. The values of sensory evaluation by 10 monitors were totaled to calculate the average value. As shown below, it was assumed that good results were obtained when the average value was 60 points or more. The results are shown in Table 1.

⊚: 80 points or more ○: 60 points or more and less than 80 points △: 40 points or more and less than 60 points ×: less than 40 points (relaxing effect)
The relaxing effect was measured by measuring the GSR of 10 monitors.

The GSR measurement procedure will be described below.
First, 10 monitors rested for 10 minutes as a resting period, and then a Kleperin test was continuously performed for 20 minutes as a stress task. Then, 10 ml of the prepared oral composition as a mouthwash was contained in the mouth, and the mouth was washed for 20 seconds. After spitting out the mouthwash, the patient was rested for 20 minutes as a recovery period. The GSR was measured by the GSR measurement sensor attached to the monitor throughout the rest period, stress task, and recovery period. The GSR measurement was repeatedly performed by 10 monitors using the mouthwashes of each Example and each Comparative Example according to the above-mentioned GSR measurement procedure.

For the evaluation of the relaxing effect, the Z value obtained by standardizing the measured value of GSR was used. The Z value was calculated from Z = (X−μ) / σ. Here, X means sample data, μ means the average of X, and σ means the standard deviation. The Z value increases during the stress task and then gradually decreases. The absolute value of the amount of change in the Z value for 10 minutes after the end of the stress task was measured with reference to the end of the stress task. The average value of 10 people was calculated, and it was assumed that good results were obtained when the average value was 1.0 or more as follows. The results are shown in Table 1.

(Evaluation criteria)
⊚: 1.2 or more ○: 1.0 or more and less than 1.2 Δ: 0.8 or more and less than 1.0 ×: less than 0.8

表１に示されるように、比較例１では、Ｂ成分のリモネンとリナロールの両方、及び、Ｃ成分の酢酸リナリルの含有量が本発明において規定の含有量より少ないため、各実施例に対してリラックス効果が十分ではなかった。また、比較例２では、Ｃ成分の酢酸リナリルの含有量が本発明において規定の含有量より少ないため、比較例１よりは効果があったもののリラックス効果が十分ではなかった。

As shown in Table 1, in Comparative Example 1, since the contents of both limonene and linalool of the B component and linalyl acetate of the C component are smaller than the contents specified in the present invention, for each example, The relaxing effect was not enough. Further, in Comparative Example 2, since the content of linalyl acetate of the C component was less than the content specified in the present invention, it was more effective than Comparative Example 1, but the relaxing effect was not sufficient.

Claims (5)

Ingredient A: Mint-based fragrance and
Ingredient B: At least one selected from limonene and linalool,
C component: An oral composition containing an acetic acid ester compound.
The A component is 0.01 to 0.6% by mass,
Among the B components, 0.01% by mass or more of the limonene and / or 0.001% by mass or more of the linalool.
An oral composition comprising 0.001% by mass or more of the C component. The oral composition according to claim 1, wherein the mint-based flavor is at least two or more selected from menthol, menthone, and isomenthon. The oral composition according to claim 1 or 2, wherein the acetic acid ester compound is at least one selected from ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, hexenyl acetate, benzyl acetate, linaryl acetate, and geranyl acetate. Stuff. The oral composition according to any one of claims 1 to 3, which contains the limonene as the B component. The oral composition according to any one of claims 1 to 4, which is composed of a liquid.