JP2013067568A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition capable of continuing a high bactericidal effect on bacteria in the oral cavity, improving use feeling (lowering of irritation) and an appearance stability (reduction of turbidity ), and having a high dental caries preventing effect.SOLUTION: This dentifrice composition containing no abrasive contains (A) cationized cellulose, (B) cationic fungicide, and (C) amphoteric surfactant, wherein a mass ratio of (A) cationized cellulose/(B) fungicide o is 0.1-10.

Description

  The present invention relates to a dentifrice composition having a high caries prevention effect.

  The cause of the two major oral diseases of caries and periodontal disease is considered to be caused by various bacteria in the oral cavity. In particular, caries is an infection caused by bacteria such as Streptococcus mutans (S. mutans), and periodontal disease is mainly anaerobic gram-negative bacilli such as Porphyromonas gingivalis. In addition, oral bacteria such as Fusobacterium nucleatum are involved as a cause of bad breath. Therefore, it is said that it is useful to keep the number of pathogenic bacteria in the oral cavity at a low level as an effective means for prevention and improvement of oral diseases.

  In order to reduce the number of pathogenic bacteria in the oral cavity, it is effective to use a slightly water-soluble fungicide, a cationic fungicide, or an anionic fungicide. In particular, cationic bactericides have a high bactericidal effect, and it is known that the action reduces the total number of bacteria in the oral cavity and suppresses the formation of plaque causing disease.

  However, cationic bactericides form complexes with anionic surfactants such as sodium lauryl sulfate, a foaming agent used in dentifrices, and the bactericidal effect may be significantly reduced. Similarly, if it coexists with a nonionic surfactant, it is taken into the micelle and the bactericidal effect is lowered.

  As means for solving this problem, a technique (Patent Document 1) for improving the bactericidal power by reducing the amount of the nonionic surfactant, or the oral cavity of a cationic bactericide by combining a cationic bactericide and a cationic polymer. Techniques (Patent Document 2, Patent Document 3, and Patent Document 4) that improve the internal retention and exert the sterilizing effect have been proposed.

JP 2006-16309 A JP 2001-64137 A JP-A-6-239725 JP 2001-139443 A

  However, in patent document 1, the special fragrance | flavor component is mix | blended and the anionic surfactant is further mix | blended. In the technique of this patent document 1, since the versatility is low in that a special perfume ingredient is blended, and further an anionic surfactant is included, it is possible to form a complex with a cationic fungicide. There was concern, and there was room for improvement in order to obtain a long-term sterilization effect.

  In Patent Documents 2, 3, and 4, a nonionic surfactant is blended. In the techniques of Patent Documents 2, 3, and 4, it can be said that there remains a problem that a bactericide is incorporated into micelles in that a nonionic surfactant is blended. Further, the nonionic surfactant may not be sufficiently foamed by itself, and if it is added in a large amount to enhance the foaming, a specific taste may occur. Moreover, since patent document 2, 4 is a proposal regarding the composition for liquid oral cavity, the proposal in a dentifrice is anticipated. Furthermore, the cationic bactericidal agent has a unique bitter taste, and when used in combination with an anionic surfactant, it may be felt as a stimulus to the user, and improvement is desired.

  The present invention has been made in view of the above, and its problem is that it can have a high bactericidal effect for bacteria in the oral cavity, and it has a feeling of use (reduction of irritation) and appearance stability (turbidity). An object of the present invention is to provide a dentifrice composition having a high effect of preventing dental caries, which also improves (reduction).

In order to solve the problems described above, the present invention provides a dentifrice composition having the following constitution.
[1] An abrasive-free dentifrice composition containing (A) cationized cellulose, (B) a cationic fungicide, and (C) an amphoteric surfactant,
A dentifrice composition having a mass ratio of (A) cationized cellulose / (B) cationic fungicide of 0.1 to 10.
[2] The dentifrice composition according to the above [1], wherein (A) the cationized cellulose is hydroxyethyl cellulose dimethyl diallylammonium chloride.
[3] The dentifrice composition according to the above [1] or [2], wherein the (B) cationic fungicide is cetylpyridinium chloride.
[4] The dentifrice composition according to any one of the above [1] to [3], wherein (C) the amphoteric surfactant is a coconut oil fatty acid amidopropyl betaine solution.

  The dentifrice composition of the present invention increases the retention in the oral cavity of the (B) cationic bactericidal agent by blending (A) cationized cellulose and (C) an amphoteric surfactant. Therefore, the dentifrice composition of the present invention can have a high bactericidal effect for bacteria in the oral cavity, resulting in a feeling of use (reduction of irritation) and appearance stability (reduction of turbidity). It is useful as a dentifrice in various dosage forms to improve the caries prevention effect.

  The dentifrice composition of the present invention contains (A) cationized cellulose, (B) a cationic fungicide, and (C) an amphoteric surfactant as active ingredients. Hereinafter, these active ingredients will be described in the order of description.

[(A) Cationized cellulose]
The cationized cellulose is a cellulose having a cation or a cellulose derivative having a cation. The cationized cellulose may have a counter ion [for example, halogen ion (chlorine ion), methosulphate ion, etc.]. The molecular weight of cationized cellulose is not particularly limited. As a component (A), a cationized cellulose may be used individually by 1 type, and may be used in combination of 2 or more type.

  Examples of cationized cellulose include hydroxyethyl cellulose dimethyl diallylammonium salt (eg, hydroxyethyl cellulose dimethyl diallylammonium chloride), O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose chloride, preferably And hydroxyethyl cellulose dimedyl diallylammonium chloride.

  By coexisting (A) cationized cellulose with (B) the cationic fungicide, the retention in the oral cavity of (B) the cationic fungicide can be improved, and the bactericidal effect of the dentifrice composition of the present invention can be improved. Can last. (A) By using hydroxyethyl cellulose dimedyl diallylammonium chloride as the cationized cellulose, it is possible to further improve the oral retention of the (B) cationic fungicide, and the sterilization of the dentifrice composition of the present invention. The sustainability of the effect can be further increased.

  (A) It is preferable that the compounding quantity of cationized cellulose is 0.001 mass%-1.0 mass% when the whole composition is 100 mass%. When the blending amount is less than 0.001% by mass, the sustainability of the intended bactericidal effect is insufficient, and when it exceeds 1.0% by mass, the amount of foam at the time of use is not an appropriate amount and the feeling of use is deteriorated. From the viewpoint of improving the sustainability of the bactericidal effect and improving the usability, the optimum blending amount is 0.05% by mass.

[(B) Cationic fungicide]
Examples of the cationic bactericidal agent include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, and the like. Although not particularly limited, cetylpyridium chloride is preferable. By adding a cationic bactericidal agent to the dentifrice composition, the total number of bacteria in the oral cavity can be greatly reduced by using the dentifrice composition, and the formation of dental plaque that causes caries is suppressed. be able to. (B) By using cetylpyridinium chloride as the cationic bactericidal agent, a further bactericidal effect can be expected.

  (B) It is preferable that the compounding quantity of a cationic disinfectant is 0.01 mass%-0.1 mass% when the whole composition is 100 mass%. If the blending amount is less than 0.01% by mass, the intended bactericidal effect is insufficient, and if it exceeds 0.1% by mass, bitterness is felt during use and the usability is deteriorated. From the viewpoint of obtaining a bactericidal effect and good usability, the optimum blending amount is 0.02% by mass.

[(C) Amphoteric surfactant]
(C) Examples of amphoteric surfactants include betaine acetate type such as coconut oil fatty acid amidopropyl betaine, lauryldimethylaminoacetic acid betaine, and imidazoline type such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt. , N-fatty acid acyl-L-alginate salts and the like, and coconut oil fatty acid amidopropyl betaine is preferably used.

  (C) The amphoteric surfactant coexists in the mixed system of (A) cationized cellulose and (B) cationic fungicide to maintain the bactericidal effect of the dentifrice composition with (B) cationic fungicide. The irritation | stimulation at the time of use of a dentifrice composition can be reduced, and a favorable usability | use_condition can be provided. (C) By using coconut oil fatty acid amide propyl betaine as an amphoteric surfactant, the sustainability of the bactericidal effect of the dentifrice composition of the present invention can be further enhanced and the usability can be improved.

  (C) It is preferable that the compounding quantity of an amphoteric surfactant is 0.1 mass%-1.0 mass% when the whole composition is 100 mass%. If the blending amount is less than 0.1% by mass, the sustainability of the intended bactericidal effect becomes insufficient, and the amount of foam at the time of use is not an appropriate amount and the feeling of use deteriorates. Bitterness is felt at the time of use and the feeling of use deteriorates. From the viewpoint of improving the sustainability of the bactericidal effect and improving the usability, the optimum blending amount is 0.3% by mass.

[(A) Mass ratio of cationized cellulose / (B) cationic fungicide]
The mass ratio of (A) cationized cellulose / (B) cationic fungicide is preferably 0.1-10. When the mass ratio is less than 0.1, (B) the sterilization effect of the cationic bactericide is insufficiently maintained, and bitterness is felt when the dentifrice composition is used. Further, if the mass ratio exceeds 10, foaming at the time of use of the dentifrice composition is deteriorated, and (B) the bactericidal effect by the cationic bactericidal agent becomes difficult to be exhibited, and as a result, the bactericidal effect is sustained. Disappear.

[No compounding of abrasive]
As described above, the dentifrice composition according to the present invention can exhibit the bactericidal effect of the (B) cationic bactericidal agent contained therein, and further, maintains this bactericidal effect and has a high caries-preventing effect. It is intended to bring to the user.
Conventionally, an abrasive is usually blended in a dentifrice composition in order to remove dirt such as plaque. However, the use of an abrasive may invade teeth and oral mucosa. It is considered that there is a particular concern for so-called caries high-risk individuals who are particularly susceptible to caries.
As described above, the dentifrice composition of the present invention is intended to provide the user with a high caries prevention effect. Therefore, the dentifrice composition of the present invention is a dentifrice composition that does not contain an abrasive that may adsorb an active ingredient (containing no abrasive), so that the above-described essential components (A) and (B ) And (C) can exhibit a high caries prevention effect.
As explained above, in the present invention, since the bactericidal effect of the blended (B) cationic fungicide can be maximized, the total number of bacteria in the oral cavity can be obtained by using the dentifrice composition of the present invention. Can be greatly reduced, and the formation of dental plaque causing caries can be suppressed. Therefore, even if the abrasive that has been responsible for removing plaque in the conventional dentifrice composition is not blended in the dentifrice composition of the present invention, there will be no problem with plaque formation.

[Dosage form of dentifrice composition of the present invention]
The dosage form of the dentifrice composition of the present invention is not particularly limited, and examples thereof include powder toothpaste, moistened toothpaste, toothpaste, liquid toothpaste, liquid toothpaste and gel toothpaste, preferably toothpaste, liquid toothpaste and liquid. It is toothpaste and gel-like toothpaste.

[Method for producing dentifrice composition of the present invention]
The manufacturing method of the dentifrice composition of this invention is not specifically limited, According to dosage form, it can select suitably. For example, the essential components (A) to (C), water, and other optional components used as necessary can be blended and prepared by a usual method.

[Other ingredients]
Examples of optional components other than the essential components (A) to (C) that can be blended in the dentifrice composition of the present invention include a binder, a thickener, a medicinal component, a fragrance, a sweetener, a colorant, a preservative, and the like. Is mentioned. The optional component may be one kind or a combination of two or more kinds. Optional components can be selected according to the dosage form.

  The binder is not particularly limited as long as it is other than the component (A) cationized cellulose. Examples include the following: cellulose derivatives such as sodium carboxymethylcellulose, sodium hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, methylcellulose; carrageenan, guar gum, tragacanth gum, caraya gum, arabiya gum, locust bean gum, sodium alginate Polysaccharides such as polyvinyl alcohol, carboxyvinyl polymer, etc .; inorganic substances such as silica gel, laponite, and aluminum silica gel; clay minerals such as montmorillonite and bee gum. The binder may be one type or a combination of two or more types.

  Although the compounding quantity in the case of mix | blending a binder is not specifically limited, For example, when the whole composition is 100 mass%, it is 0.2-3 mass% normally, for example.

  Examples of the thickener include the following: sugar alcohols such as sorbit, xylit, maltitol, and lactitol; polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, 1,3-butylene glycol, and polypropylene glycol. Alcohols such as ethanol and denatured ethanol; sugar alcohol-reduced starch saccharified products and the like.

  One type of thickener may be used, or a combination of two or more types may be used. Although the compounding quantity in the case of mix | blending a viscous agent is not specifically limited, When the whole composition is 100 mass%, it is 5-60 mass% normally.

  The medicinal component may be any medicinal or active component that can be added to the dentifrice composition other than the component (B) cationic fungicide. The blending amount can be blended in an effective amount as long as the effects of the present invention are not hindered. Examples include: alkali metal monofluorophosphates such as sodium fluoride and sodium monofluorophosphate, fluorine compounds such as stannous fluoride, water-soluble phosphorus such as potassium salt and sodium salt of orthophosphoric acid Acid compounds; enzymes such as dextranase, amylase, proteinase, mutanase; tranexamic acid, epsilon-aminocaproic acid, aluminum chlorohydroxy allantoin, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene , Copper chlorophyllin sodium, chlorophyll, chelating phosphate compounds such as glycerophosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, Hydroxamic acid and its derivatives, glycyrrhizic acid and its salts, glycyrrhetinic acid maleic anhydride copolymer, bactericides such as polyvinylpyrrolidone, epidihydrocholesterin, trichlonsan, lysozyme chloride, anticalculus agents such as polyphosphates and zeolites. The medicinal component (active ingredient) may be one type or a combination of two or more types.

  The perfume may be any known perfume material used in the dentifrice composition, and examples thereof include the following: peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, Thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, bay oil, Natural fragrances such as lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute peppermint, absolute rose, orange flower; processed natural fragrances (front reservoir cut, rear reservoir) Cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.) Fragrances obtained by: menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate , N-substituted-paramentane-3-carboxamide, pinene, octyl acetate, citral, pulegone, calbetoacetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycine Dating, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, Single flavors such as roten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacetate; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical Blended fragrances such as fruit flavors.

  The perfume may be one kind or a combination of two or more kinds. Although the compounding quantity in the case of mix | blending a fragrance | flavor is not specifically limited, Usually, it is 0.000001-1 mass% when the whole composition is 100 mass%. When mix | blending the said fragrance | flavor raw material as a fragrance | flavor for fragrance | flavors, it is preferable that the compounding quantity of the fragrance | flavor for fragrance | flavors is 0.05-2 mass% when the whole composition is 100 mass%.

  Examples of the sweetener include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, thaumatin, asparatylphenylalanine methyl ester and the like.

  Examples of the colorant include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201 and Blue No. 204. , Green No. 3, titanium oxide and the like.

  Examples of the preservative include parabens such as butyl paraben, methyl paraben and ethyl paraben, paraoxybenzoic acid ester, sodium benzoate and the like.

  The amount of the sweetener, the colorant, and the preservative to be blended can be set to the usual blending amount for each dentifrice as long as the effects of the present invention are not hindered.

  The container which accommodates the dentifrice composition of this invention is not restrict | limited in particular, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

[Examples 1 to 10 and Comparative Examples 1 to 6]
A dentifrice composition sample having the composition and composition amount shown in the following (Table 1) and (Table 2) was produced according to the following production procedure.

(Procedure for preparing dentifrice composition)
(A) A phase was prepared by mixing and dissolving water-soluble components (excluding binder, propylene glycol, etc.) in purified water at room temperature.
(B) A phase B in which a binder and a cationic bactericide were dispersed at room temperature in propylene glycol was prepared.
(C) B phase was added and mixed with the A phase under stirring, and C phase was prepared.
(D) In the C phase, ingredients other than water-soluble ingredients such as fragrances and surfactants are mixed at room temperature using a 5 kg vacuum emulsifier (manufactured by Mizuho Kogyo Co., Ltd.) and defoamed under reduced pressure (3000 Pa). The dentifrice composition 5kg was obtained.

  In producing the dentifrice composition shown in the following (Table 1) and (Table 2), as hydroxyethyl cellulose dimethyl diallyl ammonium chloride, “Cell Coat L-200 (trade name)” marketed by Akzo Nobel Co., Ltd. is available. For cetylpyridinium chloride, “cetylpyridinium chloride (trade name)” marketed by Wako Pure Chemical Industries, Ltd., coconut oil fatty acid amidopropyl betaine as the amphoteric surfactant, and other raw materials In all cases, products conforming to the original regulations were used.

  The following evaluation was performed about the dentifrice composition of each Example shown in the said (Table 1) and (Table 2) produced based on the said preparation procedure, and each comparative example.

(1) Evaluation of persistence of bactericidal effect by cationic bactericides (Method for evaluating bactericidal effect persistence)
Hydroxyapatite powder as a tooth surface model was stirred in human filtered saliva for 30 minutes. Then, each dentifrice composition sample shown in the above (Table 1) and (Table 2) diluted 3 times with water to hydroxyapatite powder was added and stirred for 60 minutes.
Next, the diluted dentifrice solution was removed, and each hydroxyapatite powder was washed 4 times, 6 times, 8 times and 10 times with phosphate buffer (pH 7.0, 10 mM), and the washing solution was removed. A THBHM medium was added to the hydroxyapatite powder for each washing. Actinomyces viscosus T14V was added to each medium, and anaerobic culture was performed at 37 ° C. for 24 hours.
The growth inhibition state of the bacteria after the culture was visually evaluated.
The bactericidal effect persistence was evaluated according to the following criteria based on the average value of the number of washings before the number of washings until the growth of the bacteria was observed by performing this test three times. In the following evaluation criteria, for example, the evaluation that the number of times of washing is 10 is that the bactericidal effect by the dentifrice composition remains on the hydroxyapatite powder even after 10 times of washing, and thus no growth of bacteria is observed. means.

(Evaluation criteria for bactericidal effect persistence)
Double circle: Washed 10 times
Circle (○): Number of cleanings 8 to less than 10 Triangle (△): Number of cleanings 6 to less than 8 X (x): Number of cleanings less than 4 Double circle, circle, triangle The results of evaluation of the bactericidal effect persistence indicated by cross marks are shown in the column “Durability of cationic fungicides” in (Table 1) and (Table 2).

(2) Evaluation of bactericidal power of dentifrice composition (Method for evaluating bactericidal power)
40 μL of the Porphyromonas gingivalis culture solution that had been cryopreserved contains Todd Hewit broth (Becton and Dickinson) containing 5 mg / L hemin (manufactured by Sigma) and 1 mg / L vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.). The product was added to 4 mL of a culture solution (THBHM) and anaerobic (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) was cultured overnight at 37 ° C. to obtain a bacterial solution.
After adding 49 mL of THBHM medium to 1 g of each dentifrice composition sample shown in (Table 1) and (Table 2) and stirring, THBHM medium is further added, and the dilution rate of each dentifrice composition is 400 to 2400 times. A dilution medium for each dentifrice composition was prepared as described above.
50 μL of the above bacterial solution was added to 3 mL of the diluted medium of each dentifrice composition obtained, and anaerobic culture was performed at 37 ° C. for 10 days.
The presence or absence of growth of the bacteria after the culture was visually evaluated.
The bactericidal power was evaluated according to the following criteria based on the highest dilution at which no growth of bacteria was observed.

(Evaluation criteria for bactericidal activity)
Double circle: Dilution degree is 1600 times or more Circle (◯): Dilution degree is 1200 times or more and less than 1600 times Triangle (△): Dilution degree is 800 times or more and less than 1200 times X (X): Dilution degree is less than 800 times The evaluation results of the bactericidal power by the double circle mark, circle mark, triangle mark, and cross mark display are shown in the “bactericidal power” column of (Table 1) and (Table 2).

(3) Evaluation of good feeling of use (Evaluation method of good feeling of use)
Using 10 test subjects, about 1 g of each dentifrice composition sample shown in the above (Table 1) and (Table 2) was taken on a toothbrush and evaluated for the following criteria on the irritation felt during use for brushing for 3 minutes. did.

(Evaluation criteria 1 for good usability)
3 points: I do not feel stimulation 2 points: I feel some stimulation 1 point: I feel stimulation I averaged the evaluation results of 10 people based on the above evaluation criteria, and also evaluated the feeling of use (less irritation) according to the following criteria .
(Evaluation criteria 2 for good usability)
Double circle: The average score of stimulus evaluation is 2.5 or more and 3.0 or less Circle (◯): The average score of stimulus evaluation is 2.0 or more and less than 2.5 Triangle (△): Average of evaluation of stimulus Point is 1.5 or more and less than 2.0 x (x): average point of evaluation of stimulation is 1.0 or more and less than 1.5 Good feeling of use due to the above double circle mark, circle mark, triangle mark, cross mark display The evaluation results are shown in the “Dentability of toothpaste (degree of irritation)” column in (Table 1) and (Table 2).

(4) Evaluation of the amount of foam when brushing teeth (Method for evaluating the amount of foam when brushing teeth)
Using 10 test subjects, about 1 g of each dentifrice composition sample shown in the above (Table 1) and (Table 2) was put on a toothbrush, and the final foam amount when brushing for 3 minutes was evaluated according to the following criteria. did.

(Evaluation criteria 1 for the amount of foam when brushing teeth)
3 points: Easy to polish with a moderate amount of foam 2 points: Slightly less foam or slightly more difficult to polish 1 point: Too little foam amount or too hard to polish 10 results based on the above evaluation criteria On average, the foaming feeling was evaluated according to the following criteria.
(Evaluation criteria 1 for the amount of foam when brushing teeth)
Double circle: Average point of foam amount evaluation is 2.5 or more and 3.0 points or less Circle (◯): Average point of bubble amount evaluation is 2.0 points or more and less than 2.5 points Triangle (△): Bubble amount The average score of evaluation is 1.5 points or more and less than 2.0 points X (x): The average score of bubble amount evaluation is less than 1.5 points The amount of bubbles by the above double circle mark, circle mark, triangle mark, cross mark display The evaluation results are shown in the “Dentability of the dentifrice (amount of foam)” column in (Table 1) and (Table 2).

(5) Evaluation of appearance (turbidity) of dentifrice (Evaluation method of appearance (turbidity) of dentifrice)
60 g of each dentifrice composition sample shown in the above (Table 1) and (Table 2) was filled in a blow tube, each sample was stored for 3 months at -5 ° C, returned to room temperature (25 ° C) for 1 day After leaving, each dentifrice sample is pushed out of the tube on paper with two 0.2mm width lines drawn at 0.5mm intervals, and the light of a shakassen (medical radiograph observer) is applied from the back of the paper. Then, the state of turbidity of each dentifrice composition sample was evaluated according to the following criteria according to the appearance of the line.

(Evaluation criteria 1 for appearance (turbidity) of dentifrice)
3 points: 2 are clearly visible 2 points: 1 are clearly visible 1 point: 2 are both cloudy The average value of 3 evaluation points of each dentifrice composition sample is obtained, and the appearance (turbidity) is determined according to the following criteria ) Was evaluated.
(Evaluation criteria 2 for appearance (turbidity) of dentifrice)
Double circle: Average point of turbidity evaluation is 2.5 or more and 3.0 point or less Circle (○): Average point of turbidity evaluation is 2.0 point or more and less than 2.5 points Triangle (△): Average of turbidity evaluation 1.5 points or more and less than 2.0 points x (x): The average score of turbidity evaluation is less than 1.5 points Appearance of the dentifrice by the double circle mark, circle mark, triangle mark and cross mark display (turbidity) ) Evaluation results are shown in the "Appearance of dentifrice (turbidity)" column in (Table 1) and (Table 2).

  The dentifrice compositions of Examples 1 to 10 are “sustained effect on cationic fungicide”, “bactericidal power”, “feel of use of dentifrice (degree of irritation)”, “feel of use of dentifrice (foam amount). ”And“ appearance of dentifrice (turbidity) ”, and at least one evaluation item is evaluated as a double circle (Table 1). On the other hand, none of the dentifrice compositions of Comparative Examples 1 to 6 has obtained good evaluation in all evaluation items, and evaluation is impossible or at least one evaluation item is obtained in at least one evaluation item (Table 2). ).

  This means that the dentifrice composition of the present invention can have a high bactericidal effect on bacteria in the oral cavity and has a feeling of use (reduction of irritation) and appearance stability (reduction of turbidity). It also shows that it is a dentifrice composition with a high caries prevention effect that is improved.

Claims (4)

A dentifrice composition containing no abrasive and containing (A) cationized cellulose, (B) a cationic fungicide, and (C) an amphoteric surfactant,
A dentifrice composition having a mass ratio of (A) cationized cellulose / (B) cationic fungicide of 0.1 to 10.   The dentifrice composition according to claim 1, wherein (A) the cationized cellulose is hydroxyethyl cellulose dimethyl diallylammonium chloride.   (B) The dentifrice composition according to claim 1 or 2, wherein the cationic fungicide is cetylpyridinium chloride.   (C) The dentifrice composition according to any one of claims 1 to 3, wherein the amphoteric surfactant is a coconut oil fatty acid amidopropyl betaine solution.