WO2016133063A1

WO2016133063A1 - Oral liquid composition

Info

Publication number: WO2016133063A1
Application number: PCT/JP2016/054370
Authority: WO
Inventors: 友美子平嶋; 赤羽　康宏
Original assignee: ライオン株式会社
Priority date: 2015-02-17
Filing date: 2016-02-16
Publication date: 2016-08-25
Also published as: KR102491340B1; JP2016150912A; JP6547324B2; KR20170117406A; CN107249546B; MY183114A; CN107249546A

Abstract

Provided is an oral liquid composition which is prepared by adding, to an oral liquid composition being free from ethanol and comprising potassium nitrate (A)and cetyl pyridinium chloride (B), a nonionic surfactant (C) and an amphoteric surfactant (D), wherein the content of water (E) is controlled to 55 mass% or higher and lower than 92 mass% and the pH of the composition is adjusted to 6.8 or higher and lower than 8.0. The oral liquid composition, wherein the sedimentation of an insoluble precipitate, said precipitate being formed by the combined use of the components (A) and (B) in the aforesaid oral liquid composition, is suppressed, has excellent effects of suppressing hypersensitivity and preventing dental caries.

Description

Liquid oral composition

The present invention relates to a liquid oral composition containing no potassium nitrate and containing no ethanol, which is excellent in hypersensitivity suppression effect and bactericidal effect in the oral cavity.

As a preventive measure against dentin hypersensitivity, known potassium nitrate is blended into the oral composition as an active ingredient (Patent Documents 1 and 2). This potassium nitrate has a problem that an insoluble precipitate is formed in the presence of sodium lauryl sulfate which is generally blended in an oral composition. In Patent Document 3, there are many oral compositions containing potassium nitrate and sodium lauryl sulfate. By adding a monohydric alcohol and an amphoteric surfactant, precipitation of potassium lauryl sulfate is prevented and low temperature precipitation is suppressed.
In addition, non-alcohol type liquid preparations with less mucosal irritation and low irritation are more suitable for suppressing hypersensitivity particularly in liquid oral compositions.

On the other hand, cetylpyridinium chloride, a cationic fungicide, has an excellent bactericidal effect on airborne bacteria in the oral cavity and is effective in preventing or suppressing oral diseases such as caries, but is easily affected by a surfactant. In Patent Document 4, a specific compound is added to an oral composition containing a biguanide-based cationic fungicide and a nonionic surfactant to prevent deactivation of the cationic fungicide by the nonionic surfactant. Then, a stabilized blending technique has been proposed.

U.S. Pat. No. 3,863,006 Japanese Patent Laid-Open No. 7-101842 JP 2005-68071 A JP 60-255717 A JP 2013-35792 A JP 2007-84471 A

Therefore, if non-alcohol type liquid oral preparation containing potassium nitrate can suppress hypersensitivity and at the same time exert high bactericidal power against oral floating bacteria, it is more effective for prevention or suppression of oral diseases. However, the current situation is that it is difficult with conventional techniques, and the development of liquid oral preparations having such excellent characteristics has been desired.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an ethanol-free liquid oral composition containing potassium nitrate, which is excellent in the hypersensitivity suppressing effect and the bactericidal effect of airborne bacteria in the oral cavity.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) potassium nitrate and (B) cetylpyridinium chloride are combined with an ethanol-free liquid oral composition, and (C) nonionic By blending a surfactant and (D) an amphoteric surfactant, (E) the water content is 55% by mass or more and less than 92% by mass, and the pH of the composition is 6.8 or more and less than 8.0 by ( A), non-alcohol-type liquid oral composition is obtained, in which precipitation of insoluble precipitates generated by the combined use of components (B) is suppressed, and the perceptual hypersensitivity suppressing effect and the bactericidal effect of airborne bacteria in the oral cavity are excellent. The present inventors have found that it can be suitably used for caries suppression and have made the present invention.

In other words, it was expected that potassium nitrate-containing cetyl chloride and potassium nitrate and cetyl chloride were expected to be added to the liquid oral composition containing potassium nitrate by adding cetylpyridinium chloride, a cationic fungicide, to prevent hypersensitivity and bactericidal bacteria. When pyridinium is blended into an ethanol-containing liquid oral composition, it is formulated with potassium nitrate and cetylpyridinium chloride in combination with a mild oral ethanol-free liquid oral composition, even though there are no particular problems. Then, it discovered that an insoluble precipitate was produced and precipitated, and this caused a problem that the hypersensitivity suppressing effect was lowered and the bactericidal effect was not sufficiently developed. For this reason, a new problem has emerged in which potassium nitrate and cetylpyridinium chloride are used in combination in a liquid oral composition containing no ethanol without precipitation of insoluble precipitates, and the effects of potassium nitrate and cetylpyridinium chloride are exhibited satisfactorily. did. Therefore, as a result of further investigation by the present inventors in order to solve these problems, (C) a nonionic surfactant and (D) an amphoteric surfactant are added in combination, and moisture in the composition is added. By setting the amount and pH within the above ranges, the precipitation of insoluble precipitates caused by the combined use of the above-described components (A) and (B) is suppressed over time, and a high perceptual hypersensitivity suppressing effect and a floating fungicidal effect are simultaneously achieved. In addition, it was possible to maintain a stable appearance, to suppress the bitterness and to give a good feeling of use. In this case, although cetylpyridinium chloride is easily deactivated due to the influence of a surfactant such as a nonionic surfactant, the combination of (C) and (D) surfactants is used in the present invention. However, the water content and pH in the composition act specifically within a specific range, and give the above-mentioned exceptional and remarkable effects.
Accordingly, as is clear from the examples described later, the liquid oral composition of the present invention containing no ethanol shows almost no insoluble precipitate even after 4 weeks have passed since the preparation of the liquid oral composition. Appearance is stable over time, high sensitivity to hypersensitivity and bactericidal effect on airborne bacteria in the oral cavity, and bitterness after use is suppressed, resulting in a good feeling of good use.

Patent Document 3 suppresses precipitation of potassium lauryl sulfate caused by the combined use of potassium nitrate and sodium lauryl sulfate in the oral composition, and Patent Document 4 describes a cationic bactericide using a nonionic surfactant. No mention is made of using a cationic bactericide in combination with potassium nitrate. Patent Documents 5 and 6 describe liquid oral compositions containing potassium nitrate and cetylpyridinium chloride, but these are ethanol-containing compositions. From Patent Documents 3 to 6, the suppression of precipitation of insoluble precipitates caused by the combined use of potassium nitrate and cetylpyridinium chloride in a liquid oral composition containing no ethanol cannot be predicted.

Accordingly, the present invention provides the following liquid oral composition and a method for suppressing the precipitation of insoluble precipitates in the composition.
[1]
(A) A non-ethanol-containing liquid oral composition containing potassium nitrate and (B) cetylpyridinium chloride, (C) a nonionic surfactant and (D) an amphoteric surfactant, and (E) water content The composition for liquid oral cavity, wherein the pH of the composition is 6.8 or more and less than 8.0.
[2]
(C) The liquid oral composition according to [1], wherein the nonionic surfactant is polyoxyethylene hydrogenated castor oil, and (D) the amphoteric surfactant is alkylamide betaine or a salt thereof.
[3]
(C) The nonionic surfactant is polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 mol, and (D) the amphoteric surfactant is coconut oil fatty acid amidopropyl betaine [ 1] or [2] liquid oral composition.
[4]
The liquid oral composition according to [1], [2] or [3], wherein 0.1 to 2% by mass of component (C) and 0.1 to 2% by mass of component (D) are blended.
[5]
The liquid oral composition according to any one of [1] to [4], wherein 0.01 to 10% by mass of component (A) and 0.001 to 0.1% by mass of component (B) are blended.
[6]
The liquid oral composition according to any one of [1] to [5], which is a mouthwash.
[7]
The liquid oral composition according to any one of [1] to [6], which is used for suppressing hypersensitivity and caries.
[8]
(A) A non-ethanol-containing liquid oral composition containing potassium nitrate and (B) cetylpyridinium chloride, (C) a nonionic surfactant and (D) an amphoteric surfactant, and (E) water content 55% by mass or more and less than 92% by mass, and the pH of the composition is 6.8 or more and less than 8.0, wherein (A) potassium nitrate and (B) cetylpyridinium chloride in the liquid oral composition A method for suppressing the precipitation of insoluble precipitates produced by the combined use.
[9]
The method for suppressing precipitation of insoluble precipitates produced by the combined use of (A) potassium nitrate and (B) cetylpyridinium chloride in the liquid oral composition according to [8], wherein the liquid oral composition is a mouthwash.

According to the present invention, it is possible to provide a liquid oral composition containing no potassium nitrate and containing no ethanol, which is excellent in the effect of suppressing hypersensitivity and the bactericidal effect of floating bacteria in the oral cavity.

Hereinafter, the present invention will be described in further detail. The composition for liquid oral cavity of the present invention contains (A) potassium nitrate, (B) cetylpyridinium chloride, (C) nonionic surfactant, (D) amphoteric surfactant, (E) water, and contains no ethanol It is.

(A) Potassium nitrate is blended as an active ingredient for preventing or treating dentin hypersensitivity, and is a hypersensitivity inhibitor.
The blending amount of the component (A) potassium nitrate is preferably 0.01 to 10% (mass%, hereinafter the same) of the whole composition, more preferably 0.1 to 7%. As the blending amount increases, the perceptual hypersensitivity suppression effect increases, but 10% or less is more suitable for sufficient precipitation suppression and bitterness suppression.

(B) Cetylpyridinium chloride is a cationic bactericidal agent and a bactericidal agent against floating bacteria in the oral cavity. A commercially available cetylpyridinium chloride can be used.
The amount of component (B) cetylpyridinium chloride is preferably 0.001 to 0.1%, more preferably 0.005 to 0.1%, still more preferably 0.01 to 0.05% of the total composition. %. The more the compound is added, the higher the bactericidal effect, but 0.1% or less is more suitable for sufficient precipitation suppression and bitterness suppression.

In the present invention, it is important for the expression of effects to combine (C) a nonionic surfactant and (D) an amphoteric surfactant in combination. When component (C) or component (D) is lacking, an insoluble precipitate is deposited, resulting in poor perceptual hypersensitivity suppressing effect and airborne fungicidal effect. Moreover, a bitter taste is not suppressed but a usability | use_condition is inferior.

Examples of (C) nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and polyglycerin fatty acid ester, and one or more of these may be used. (E.O.) polyoxyethylene hydrogenated castor oil having an average added mole number of 40 to 100 moles, particularly 60 to 100 moles, and an alkyl group having 16 to 18 carbon atoms. O. Preferred are polyoxyethylene alkyl ethers having an average addition mole number of 10 to 40 moles, particularly 20 to 40 moles, and decaglycerin monofatty acid esters polyglycerin fatty acid esters having a fatty acid number of 12 to 18, particularly 12 to 14, among others. E. O. Polyoxyethylene hydrogenated castor oil having an average added mole number of 40 to 100 moles is preferred.

Specifically, commercialized products as shown below that are commercialized can be used.
Polyoxyethylene hydrogenated castor oil;
NIKKOL HCO manufactured by Nikko Chemicals, Emalex HC manufactured by Nippon Emulsion, UNIOX HC manufactured by Nippon Yushi Co., Ltd. polyoxyethylene alkyl ether;
NIKKOL BC series, NIKKOL BS series manufactured by Nikko Chemicals, Emalex 100 series, Emalex 600 series decaglycerin mono fatty acid ester manufactured by Nippon Emulsion Co., Ltd .;
NIKKOL Decagln series manufactured by Nikko Chemicals, Ryoto (registered trademark) polyglycerester D series manufactured by Mitsubishi Chemical Foods

The blending amount of the nonionic surfactant as the component (C) is preferably 0.1 to 2% of the total composition, more preferably 0.1 to 1%, still more preferably 0.2 to 0.5%. is there. When 0.1% or more is blended, a sufficient precipitation suppressing effect, a hypersensitivity suppressing effect and a floating bacteria sterilizing effect are exhibited, and the bitterness can be sufficiently suppressed. 2% or less is more suitable for preventing the perceptual hypersensitivity suppressing effect and the floating bacteria bactericidal effect from decreasing.

(D) Amphoteric surfactants include alkylamidobetaines such as coconut oil fatty acid amidopropylbetaine or salts thereof, betaine acetates such as lauryldimethylaminoacetic acid betaine, N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl Examples include imidazoline type such as ethylenediamine salt, amino acid type such as N-fatty acid acyl-L-alginate salt, and the like, and one or more of these may be used, and alkylamide betaine or a salt thereof is particularly preferable. Among these, coconut oil fatty acid amidopropyl betaine is preferable.
Specifically, commercially available products such as coconut oil fatty acid amidopropyl betaine (TEGO Betaine CK OK (30% aqueous solution) manufactured by Degussa Co., Ltd., and Amphitol 55AB (30% aqueous solution) manufactured by Kao Corporation) can be used.

The blending amount of the amphoteric surfactant as component (D) is preferably 0.1 to 2% of the total composition, more preferably 0.1 to 1%, and still more preferably 0.2 to 0.5%. . When 0.1% or more is blended, a sufficient precipitation suppressing effect, a hypersensitivity suppressing effect and a floating bacteria sterilizing effect are exhibited, and the bitterness can be sufficiently suppressed. 2% or less is more suitable for preventing the perceptual hypersensitivity suppressing effect and the floating bacteria bactericidal effect from decreasing.

In the liquid oral cavity composition of the present invention, (E) the water content, that is, the water content in the composition is 55% or more and less than 92% of the whole composition, preferably 60% or more and 91% or less. Preferably they are 60% or more and 70% or less. When the amount of water is within the above range, insoluble precipitates can be prevented from being precipitated, and excellent perceptual hypersensitivity suppressing effects and bitterness suppressing effects can be imparted. If it is less than 55%, the precipitation cannot be suppressed, and the perceptual hypersensitivity suppressing effect and the floating bacteria sterilizing effect are inferior. When it is 92% or more, the precipitation suppressing effect is inferior, the perceptual hypersensitivity suppressing effect and the floating bacteria sterilizing effect are also inferior, and the bitterness cannot be suppressed.

In the present invention, the liquid oral composition has a pH of 6.8 or more and less than 8.0, preferably pH 6.8 to 7.8, more preferably pH 6.8 to 7.5. Within the above range, the precipitation suppression effect, the hypersensitivity suppression effect and the bitterness suppression effect are excellent. When the pH is less than 6.8 or pH 8.0 or more, the precipitation cannot be suppressed, and the perceptual hypersensitivity suppressing effect and the floating bacteria sterilizing effect are inferior.
The pH was measured immediately after preparation using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd., and the value after 3 minutes at 25 ° C. (the same applies hereinafter).

In the present invention, a known pH adjusting agent may be added to adjust the pH of the composition within the above range. Examples thereof include alkali metal hydrogen phosphates such as sodium dihydrogen phosphate and alkali metal hydroxides such as sodium hydroxide.

The liquid oral cavity composition of the present invention contains no ethanol. Here, “ethanol-free formulation” is one in which ethanol is not blended, but in liquid oral compositions, there are cases where a small amount of ethanol derived from the raw material is contained in the fragrance blended in the composition. In consideration of these reasons, ethanol is not included in addition to ethanol contained in a trace amount in a fragrance. In this case, the amount of ethanol in the composition is preferably 100 ppm or less, more preferably 50 ppm or less, still more preferably 10 ppm or less, and may be 0 ppm with respect to the entire composition.
In the present invention, such an ethanol-free composition suppresses the precipitation of insoluble precipitates, and exhibits an excellent perceptual hypersensitivity suppressing effect and a floating bacteria sterilizing effect.

The liquid oral cavity composition of the present invention is particularly suitable as a mouthwash. Moreover, in addition to the said component, other well-known components can be mix | blended with this invention composition in the range which does not prevent the effect of this invention as needed. Specifically, a wetting agent, a solvent, and if necessary, a sweetening agent, a coloring agent, a preservative, a fragrance, an active ingredient, and the like are blended.
In addition, it is preferable that solid components which do not solubilize, such as an abrasive | polishing agent, are not normally mix | blended with a liquid oral composition, especially a mouthwash, and an abrasive | polishing agent is not included.
Further, as the surfactant, surfactants other than (C) nonionic surfactant and (D) amphoteric surfactant may not be added, but in the case of adding 0.5% or less (0 to 0.5%), particularly 0.05 to 0.2% is desirable.

Examples of the wetting agent include sugar alcohols such as sorbitol, and polyhydric alcohols such as glycerin and polyethylene glycol. The blending amount of these wetting agents is usually 1 to 40%, particularly 2 to 40%.

As the solvent, purified water is generally used, and the water content in the composition can be added within the above range. Further, a lower monohydric alcohol having 1 to 3 carbon atoms such as ethanol, propylene glycol or the like may be blended.

As sweetening agents, xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame, and the like can be blended. As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, or the like can be added. Examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof.

Natural flavors such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Essential oils and l-menthol, l-carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, Perfume ingredients contained in the above-mentioned natural essential oils such as spiranthol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methylanthranilate, ethylmethylphenylglycidide , Benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-1-menthyl Perfume ingredients such as carbonate, and also a combination of several perfume ingredients and natural essential oils, apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, One or more kinds of blended flavors such as yogurt can be used within the range of 0.00001 to 3% in the composition without impairing the effects of the present invention.

Active ingredients include potassium nitrate, cetylpyridinium chloride, bactericides such as isopropylmethylphenol, anti-inflammatory agents such as tranexamic acid and epsilon-aminocaproic acid, enzymes such as dextranase, sodium fluoride, monofluorophosphoric acid Examples include fluorides such as sodium, allantoin, vitamins such as vitamin C, copper compounds, and plant extracts. In addition, the addition amount of these active ingredients can be made into the range which does not prevent the effect of this invention.

Hereinafter, although an Example, a comparative example, and a formulation example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. The pH was measured at 25 ° C. as described above.

[Examples and Comparative Examples]
Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 and 2 were prepared by a conventional method. When the mouthwash thus obtained was evaluated by the following methods and criteria, the results shown in Tables 1 and 2 were obtained.

(1) Evaluation method of appearance stability (precipitation suppression effect) Each mouthwash described in the table is put in 80 mL in a 100 mL PET bottle and stored in a constant temperature bath at 25 ° C., and the appearance after 4 weeks is shown below. It was judged visually according to the rating criteria. The average value of 5 samples was calculated and evaluated according to the following evaluation criteria.
Score criteria:
4 points: no precipitates 3 points: slight precipitates 2 points: some precipitates 1 point: considerable precipitates Evaluation criteria for appearance stability (precipitation suppression effect):
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 2.0 points Less than

(2) Evaluation method of hypersensitivity suppression effect Each mouthwash listed in the table was used by 5 people with dentin hypersensitivity for 1 month by mouthwashing in a normal manner, and the suppression effect of hypersensitivity Was determined according to the following criteria. An average value of five subjects was obtained and evaluated according to the following evaluation criteria.
Evaluation criteria for hypersensitivity suppression:
3 points: no longer feel pain 2 points: almost no pain 1 point: feel pain Evaluation criteria for hypersensitivity suppression effect:
◎: 2.5 points or more and 3.0 points or less ○: 2.0 points or more and less than 2.5 points △: 1.5 points or more and less than 2.0 points ×: Less than 1.5 points

(3) Method for evaluating bactericidal effect against oral floating bacteria The bacterial solution used was Streptococcus as an oral resident bacteria prepared by dissolving 30 g of Trypticase Soy Broth (Difco) in 1 L of purified water as a culture solution. Prepared by adding physiological saline so that the permeability at 550 nm of a solution cultured for 1 day under anaerobic conditions (5 vol% carbon dioxide gas, 95 vol% nitrogen) using mutans ATCC 10449 strain is 20 did. Add 0.3 mL of the bacterial solution to 2.7 mL of the sample (liquid oral composition), stir, react at 37 ° C. for 1 minute, stir again, and then add five test tubes containing 2.7 mL of the culture solution in advance. Prepared and added to the first test tube 0.3 mL of the sample with the bacterial solution added, and stirred. 0.3 mL of this solution was collected, added to the second test tube, and stirred. This operation was similarly performed in order on the third to fifth test tubes. After stirring the culture solution in the first, third, and fifth test tubes, 50 μL of the culture solution was spread on a 10% cotton defibrinated blood-containing trypticase soy agar plate (manufactured by Difco) and cultured under anaerobic conditions. The grown colonies were counted, the number of surviving Streptococcus mutans bacteria (cfu) was determined, and the bactericidal effect of planktonic bacteria was determined according to the following criteria.
Judgment criteria:
◎: Viable count is less than 10 ² ○: Viable count is 10 ² or more and less than 10 ³ △: Viable count is 10 ³ or more and less than 10 ⁴ ×: Viable count is 10 ⁴ or more

(4) Evaluation method of feeling of use (no bitterness) Each mouthwash containing 10 mL of mouthwashes listed in the table was rinsed for 30 seconds, and after the mouthwash, 5 judges were judged according to the following scoring standards. did. The average value of 5 persons was calculated | required and evaluated according to the following evaluation criteria.
Score criteria:
4 points: no bitterness 3 points: little bitterness 2 points: Some bitterness
1 point: There was considerable bitterness Evaluation criteria for feeling of use (no bitterness after mouthwash):
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 2.0 points Less than

Details of the raw materials used are shown below.
(A) Potassium nitrate; potassium nitrate super tablet (manufactured by Otsuka Food Chemical Co., Ltd.)
(B) Cetylpyridinium chloride; cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.)
(C) polyoxyethylene (100) hydrogenated castor oil;
Average number of moles of ethylene oxide added (Nikko Chemicals)
Polyoxyethylene (40) hydrogenated castor oil;
Average addition mole number of ethylene oxide 40 (manufactured by Nikko Chemicals)
(D) an alkylamidobetaine;
30% aqueous solution of palm oil fatty acid amidopropyl betaine, TEGO B
etain CK OK (Degussa)
In addition, the compounding quantity of alkylamide betaine is also a pure part conversion value also including the inside of a table | surface (following, the same).

*: In the ethanol blending composition of Comparative Example 8, even when the components (A) and (B) were blended, there was no precipitation of insoluble precipitates, and the hypersensitivity suppressing effect and the floating fungicidal effect were not reduced.

The following are examples of prescriptions. The raw materials used are the same as described above. This mouthwash was all excellent in appearance stability (precipitation suppression effect), hypersensitivity suppression effect, airborne bacteria sterilization effect, and feeling of use (no bitterness).

[Prescription example] mouthwash (A) potassium nitrate 5.0%
(B) Cetylpyridinium chloride 0.05
(C) Polyoxyethylene (60) hydrogenated castor oil 0.5
(D) Alkylamidobetaine 0.3
Glycerin 3.0
Propylene glycol 8.0
Saccharin sodium 0.1
Sodium dihydrogen phosphate 0.5
Sodium hydroxide 0.16
Fragrance 0.2
(E) Purified water 82.19
Total 100.0%
pH 6.8

Claims

(A) A non-ethanol-containing liquid oral composition containing potassium nitrate and (B) cetylpyridinium chloride, (C) a nonionic surfactant and (D) an amphoteric surfactant, and (E) water content The composition for liquid oral cavity, wherein the pH of the composition is 6.8 or more and less than 8.0.
The liquid oral composition according to claim 1, wherein (C) the nonionic surfactant is polyoxyethylene hydrogenated castor oil, and (D) the amphoteric surfactant is alkylamide betaine or a salt thereof.
(C) The nonionic surfactant is polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 mol, and (D) the amphoteric surfactant is coconut oil fatty acid amidopropyl betaine. Item 3. The liquid oral composition according to Item 1 or 2.
4. The composition for liquid oral cavity according to claim 1, wherein 0.1 to 2% by mass of component (C) and 0.1 to 2% by mass of component (D) are blended.
5. The liquid oral composition according to any one of claims 1 to 4, wherein 0.01 to 10% by mass of component (A) and 0.001 to 0.1% by mass of component (B) are blended.
The liquid oral composition according to any one of claims 1 to 5, which is a mouthwash.
The liquid oral composition according to any one of claims 1 to 6, which is used for suppressing hypersensitivity and caries.
(A) A non-ethanol-containing liquid oral composition containing potassium nitrate and (B) cetylpyridinium chloride, (C) a nonionic surfactant and (D) an amphoteric surfactant, and (E) water content 55% by mass or more and less than 92% by mass, and the pH of the composition is 6.8 or more and less than 8.0, wherein (A) potassium nitrate and (B) cetylpyridinium chloride in the liquid oral composition A method for suppressing the precipitation of insoluble precipitates produced by the combined use.
The method for suppressing precipitation of insoluble precipitates produced by the combined use of (A) potassium nitrate and (B) cetylpyridinium chloride in the liquid oral composition according to claim 8, wherein the liquid oral composition is a mouthwash.