JP2023111302A - Disinfecting composition - Google Patents

Abstract

To provide a disinfecting composition having high persistence of moisturizing effect after hand washing, excellent bactericidal effect, sense of use, and formulation stability.SOLUTION: There is provided a disinfecting composition which comprises a component A: an ester oil, a component B: a hydrophobized hydroxyalkyl cellulose, a component C: a cationic bactericide and no ethanol, wherein the content of the component A is 0.1 to 40 mass%, the content of the component B is 0.01 to 15 mass%, the content of the component C is 0.001 to 1 mass% and when the content of the component A is defined as 1 pts.mass, the content of the component D preferably is 1/4000 pts.mass or more and 150 pts.mass or less.SELECTED DRAWING: None

Description

The present invention relates to disinfecting compositions.

Conventionally, it is generally known that lower alcohols with 1 to 3 carbon atoms such as ethanol and isopropyl alcohol have a disinfecting effect on bacteria and viruses by destroying bacterial cell membranes and viral envelopes and coagulating proteins such as enzymes. Disinfectant compositions containing these lower alcohols are widely known.
However, disinfecting compositions containing lower alcohols having 1 to 3 carbon atoms, such as ethanol and isopropyl alcohol, generally have the problem of roughening the user's hands. Rough hands refer to a state in which the stratum corneum and lipid membrane have been removed, the stratum corneum has been cut, and the skin barrier function has deteriorated, and this condition makes it easier for bacteria and viruses to invade through barrier defects. Therefore, there is a demand for a disinfecting composition with excellent moisturizing properties that can prevent rough hands, that is, deterioration of the skin barrier function, while maintaining the disinfecting effect.

In order to impart an anti-roughness effect to the disinfecting composition, moisturizing ingredients such as glycerin, propylene glycol, and sorbitol are blended (for example, Patent Document 1), and moisturizing ingredients (water-soluble polyhydric alcohols) and fatty acid triglycerides are blended. Attempts have been made such as (for example, Patent Document 2).

JP-A-2004-155712 JP 2011-219410 A

However, the hands and fingers are always prone to dryness due to activities that occur in daily life, such as washing hands and touching things. It wasn't.

It is also conceivable to use a cationic disinfectant such as benzalkonium chloride, which has a high disinfecting effect, instead of lower alcohol, which is the main cause of rough hands. However, when a cationic fungicide is blended, there is a problem that the fungicidal effect is inhibited depending on the balance of other components of the composition.
Accordingly, an object of the present invention is to provide a disinfecting composition which has a long-lasting moisturizing effect after hand washing, excellent bactericidal effect, good feeling during use, and excellent formulation stability.

The disinfecting composition according to the present invention comprises component A: ester oil, component B: hydrophobized hydroxyalkyl cellulose, and component C: cationic fungicide,
does not contain ethanol
The content of the component A is 0.1 to 40% by mass,
The content of the component B is 0.01 to 15% by mass,
The content of component C is 0.001 to 1% by mass.

According to the present invention, it is possible to provide a disinfecting composition that has a long-lasting moisturizing effect after hand-washing, and is excellent in bactericidal effect, feeling of use, and formulation stability.

Preferred embodiments of the disinfecting composition of the present invention are described in detail below.
The disinfecting composition of the present invention is characterized in that it contains predetermined amounts of component A: ester oil, component B: hydrophobized hydroxyalkyl cellulose, and component C: a cationic germicide, and does not contain ethanol. are doing.
The properties of the disinfecting composition of the present invention are not particularly limited, and may be, for example, liquid, gel, emulsion, or cream. Among these, the creamy type is preferable.

<Component A>
The disinfecting composition of the present invention contains 0.1 to 40% by mass of ester oil as component A. By including the above-mentioned predetermined amount of component A, the moisturizing effect can be maintained even after washing hands with soap or the like.

Examples of ester oils include glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, isononyl isononanoate, ethylene glycol dioctanoate, glyceryl tri(capryl-caprate), isopropyl myristate, butyl myristate, isopropyl palmitate, stearin. Ethyl acid, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, decyl myristate, hexyl laurate, myristyl myristate, cetyl myristate, cetyl palmitate, stearyl stearate, oleyl oleate , decyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isotridecyl isononanoate, isocetyl myristate, isostearyl myristate, 2-octyldodecyl myristate, octyl palmitate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, 2-octyldodecyl oleate, 2-octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, cetyl octanoate, cetostearyl octanoate, stearyl octanoate, hexyl isostearate, ethylene dioleate Glycol, propylene glycol dicaprate, di(caprylic-capric) propylene glycol, propylene glycol dioleate, neopentyl glycol dicaprate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, glyceryl triundecylate, tri Glyceryl isopalmitate, glyceryl triisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, pentaerythritol tetramyristate, pentaerythritol tetraisostearate, neopentanoic acid 2-octyldodecyl, isocetyl octanoate, isostearyl octanoate, 2-hexyldecyl neodecanoate, 2-octyldodecyl neodecanoate, octyl isopalmitate, isocetyl isostearate, isostearyl isostearate, 2-octyldodecyl isostearate, lactic acid Lauryl, myristyl lactate, cetyl lactate, 2-octyldodecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, tri-2-ethylhexyl citrate, triisocetyl citrate, tri-2-octyldodecyl citrate, dimalate Isostearyl, 2-ethylhexyl hydroxystearate, dioctyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, dibutyloctyl sebacate, cholesteryl stearate, cholesteryl isostearate , cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, hexyldecyl dimethyloctanoate, diethyl phthalate, dibutyl phthalate, dialkyl carbonate, etc., and one of these Alternatively, two or more kinds can be used in combination.

Among these, it is preferable to use, as component A, at least one selected from the group consisting of isopropyl palmitate, isopropyl myristate, isotridecyl isononanoate, and cetyl 2-ethylhexanoate. By using these components, the durability of the moisturizing effect after hand washing can be increased without impairing the bactericidal effect of component C described later.

The content of component A in the disinfecting composition is 0.1 to 40% by mass, preferably 1 to 30% by mass, more preferably 3 to 20% by mass. As a result, the durability of the moisturizing effect after hand-washing can be increased without impairing the bactericidal effect of component C, which will be described later.

<Component B>
The disinfecting composition of the present invention contains 0.01 to 15% by weight of hydrophobized hydroxyalkylcellulose as component B. By including the above-mentioned predetermined amount of component B, it is possible to improve the feeling of use and the stability of the formulation without impairing the bactericidal effect of component C described later.

A hydrophobized hydroxyalkyl cellulose is obtained by introducing a long-chain alkyl group as a hydrophobic group into a hydroxyalkyl cellulose.
Hydroxyalkyl cellulose includes, for example, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose and the like. Hydrophobic groups include, for example, a stearyl group and a cetyl group.
Among these, as component B, hydrophobized hydroxypropylmethylcellulose is preferably used, and stearoxyhydroxypropylmethylcellulose is more preferably used. As a result, the feeling of use and the stability of the preparation can be improved without impairing the bactericidal effect of component C, which will be described later.

The content of component B in the disinfecting composition is 0.01 to 15% by mass, preferably 0.05 to 10% by mass, more preferably 0.1 to 1% by mass. . As a result, the feeling of use and the stability of the preparation can be improved without impairing the bactericidal effect of component C, which will be described later.

Further, when the content of component A described above is 1 part by mass, the content of component B is preferably 1/4000 parts by mass or more and 150 parts by mass or less, and 1/600 parts by mass or more and 10 parts by mass or less. and more preferably 1/200 parts by mass or more and 1/3 parts by mass or less. As a result, it is possible to further improve the durability of the moisturizing effect after hand-washing, and further improve the feeling of use and the stability of the formulation.

<Component C>
The disinfecting composition of the present invention contains 0.001 to 1% by mass of a cationic fungicide as Component C. By including the above-mentioned predetermined amount of component C, a formulation having excellent bactericidal properties can be obtained.
Examples of cationic fungicides include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, dequalinium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, and lauryltrimethylammonium chloride. , quaternary ammonium salts such as laurylpyridinium chloride, cationic fungicides such as biguanide fungicides such as alexidine gluconate, alexidine hydrochloride, alexidine acetate, chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine hydrochloride, and chlorhexidine gluconate. , among these, it is possible to use one or a combination of two or more.

Among these, it is preferable to use benzalkonium chloride and/or benzethonium chloride as the C component. As a result, it is possible to exhibit higher bactericidal activity while providing excellent usability and stability of the formulation.

The content of component C in the disinfecting composition is 0.001 to 1% by mass, preferably 0.005 to 0.5% by mass, and 0.01 to 0.3% by mass. is more preferable. As a result, it is possible to make the bactericidal property more effective and excellent while providing excellent usability and stability of the formulation.

<Ethanol>
The disinfecting composition of the present invention does not contain ethanol. As a result, the occurrence of rough hands can be suppressed.
As used herein, the expression "free of ethanol" means that the content of ethanol in the disinfecting composition is 0.5% by mass or less.
In addition, it is preferable not to contain lower alcohols (alcohols having 3 or less carbon atoms, such as isopropanol) other than ethanol. As a result, it is possible to more reliably suppress the occurrence of rough hands.

<Component D>
The disinfecting composition of the present invention preferably contains glycerin fatty acid ester as Component D. By containing such a component D, the durability of the moisturizing effect can be increased even when the skin is washed by hand. In addition, the feeling of use and the stability of the formulation can be enhanced.
Glycerin fatty acid esters include glyceryl monocaprylate, glyceryl monocaprate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monoisostearate, glyceryl diisostearate, monohydroxy Monoglycerin fatty acid esters such as glyceryl stearate, glyceryl monooleate, glyceryl monobehenate, glyceryl dibehenate, polyglyceryl monostearate (diglyceryl monostearate (polyglyceryl-2 stearate), tetraglyceryl monostearate (polyglyceryl stearate) -4), pentaglyceryl monostearate (polyglyceryl-5 stearate), hexaglyceryl monostearate (polyglyceryl-6 stearate), decaglyceryl monostearate (polyglyceryl-10 stearate), polyglyceryl monooleate ( Diglyceryl monooleate, tetraglyceryl monooleate, hexaglyceryl monooleate, decaglyceryl monooleate, etc.), polyglyceryl monolaurate (hexaglyceryl monolaurate, decaglyceryl monolaurate, etc.), polyglyceryl monomyristate (monomyristate hexaglyceryl, decaglyceryl monomyristate, etc.), polyglycerin fatty acid monoesters such as diglyceryl monoisostearate; polyglycerin fatty acid diesters such as diglyceryl dioleate, decaglyceryl distearate, decaglyceryl diisostearate; tetraglyceryl tristearate , hexaglyceryl tristearate, decaglyceryl tristearate, decaglyceryl trioleate, and other polyglycerol fatty acid triesters; and polyglycerin fatty acid esters such as polyglycerin fatty acid pentaesters, etc., and among these, one or more of them can be used in combination.

Among these, polyglycerin fatty acid monoester is preferably used, polyglyceryl monostearate is more preferably used, and polyglyceryl-5 stearate is even more preferably used.

The content of component D is preferably 0.01 to 15% by mass, more preferably 0.1 to 10% by mass, even more preferably 1 to 5% by mass. Thereby, the stability of the formulation can be improved. Moreover, the durability of the moisturizing effect can be made more excellent.

When the content of component A described above is 1 part by mass, the content of component D is preferably 1/4000 parts by mass or more and 150 parts by mass or less, and is 1/3000 parts by mass or more and 10 parts by mass or less. More preferably, it is 1/20 to 5/3 parts by mass. As a result, the stability of the formulation can be made particularly excellent while maintaining excellent moisturizing effects and feeling during use.

<Other ingredients>
In addition to the above components, the disinfectant composition of the present invention may contain other commonly used components depending on the purpose and dosage form.
Examples of such ingredients include hyaluronic acid, hyaluronic acid salts, heparinoids, nicotinamide, antioxidants, mineral/synthetic oils, animal and vegetable oils, waxes, fatty acids, alcohols (other than lower alcohols), and polymer compounds. , animal and plant extracts, amino acids, solvents, anti-inflammatory agents, preservatives, UV inhibitors, sequestering agents, antioxidants, pH adjusters, dyes/pigments, fragrances, etc., which do not impair the effects of the present invention. It can be blended in a range. Specific examples thereof are given below.

(antioxidant)
Examples of antioxidants include vitamin E and derivatives thereof (dl-α(β,γ)-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, dl-α-tocopherol linoleate, tocopherol such as dl-α-tocopherol succinate and its derivatives, ubiquinones, etc.), vitamin A and its derivatives (retinol palmitate, retinol acetate and other retinol and its derivatives, dehydroretinal and other retinal and its derivatives, etc.), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acids, benzyl nicotinate) nicotinic acids, cholines, etc.), vitamin C and its derivatives (L-ascorbyl alkyl esters such as L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate, L-ascorbyl phosphate, L-ascorbyl acid sulfate ester, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal, etc.), rutin and its derivatives, thiotaurine, taurine, hydroquinone and its derivatives, histidine, catechin and its derivatives, glabridin, glabren , liquiritin, isoliquiritin, and licorice extracts containing these.

(mineral/synthetic oil)
Mineral/synthetic oils include, for example, liquid paraffin, liquid isoparaffin, petrolatum, paraffin, ceresin, microstarin wax, α-olefin oligomer, polyethylene, polybutene, synthetic squalane, etc. One or two of these The above can be used in combination.

(animal and vegetable oils)
Animal and vegetable oils include, for example, squalane, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea butter, liquid shea butter, palm oil, palm kernel oil, hydrogenated oil, horse oil, and lanolins. , egg yolk oil, clove oil, rosehip oil, lavender oil, peppermint oil, spearmint oil, rosemary oil, macadamia nut oil, apricot kernel oil, safflower oil, safflower oil (2), sunflower oil, sunflower oil (2), Meduhome oil, almond oil, perilla oil, sesame oil, borage oil, cacao butter, rice bran oil, rice germ oil, fennel oil, orange oil, chamomile oil, cucumber oil, kukui nut oil, soybean oil, tea tree oil, corn oil, Rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, argania spinosa kernel oil, cranberry avicinica seed oil, almond oil, peach kernel oil, grapeseed oil, emu oil, mink oil, cannabis Seed oil, linseed oil, sasanqua oil, Japanese wax, coconut oil, evening primrose oil, pistachio seed oil, mango butter, etc., may be used alone or in combination of two or more of these.

(waxes)
Waxes include, for example, jojoba oil, beeswax, carnauba wax, rice bran wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac, and orange roughy oil. It can be used alone or in combination of two or more.

(fatty acid)
Examples of fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, and lanolin. Natural fatty acids such as fatty acids, synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, isopentanoic acid, etc., and among these, one or a combination of two or more can be used.

(alcohol)
The disinfecting composition of the present invention may contain alcohols other than lower alcohols, such as ethanol and isopropanol.
Such alcohols include, for example, butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyldecanol, behenyl alcohol, octyldodecanol, lanolin alcohol, cholesterol, Phytosterol, 2-hexyldecanol, 2-octyldodecanol, batyl alcohol, etc., may be used alone or in combination of two or more thereof.

(silicon oil)
Examples of silicone oils include methylpolysiloxane, methylphenylpolysiloxane, silicone resin, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and cyclic silicon. Resin, octamethyltrisiloxane, tetradecamethylhexasiloxane, high polymerization methylpolysiloxane, trimethylsiloxysilicate, poly(oxyethylene・oxypropylene) methylpolysiloxane copolymer, poly(oxyethylene・oxypropylene)・butylene・Methylpolysiloxane copolymer, polyoxyethylene/methylpolysiloxyacid copolymer, polyoxypropylene/methylpolysiloxane copolymer, dimethylsiloxane/methylcetyloxysiloxane copolymer, dimethylsiloxane/methylstearoxysiloxane copolymer and the like, and among these, one kind or two or more kinds can be used in combination.

(Surfactant)
Surfactants other than component D may be included.
Examples of such surfactants include lauryl sulfate, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, lauroyl sarcosinate, alkylmethyl-β-alanine. salt, polyoxyethylene alkyl ether phosphate, fatty acid soap, N-acyl glutamate, lauric acid diethanolamide, coconut oil fatty acid diethanolamide, alkyldimethylamine oxide, alkylmethyltaurate, alkylaminopropionate, polyoxyethylene Alkyl ether carboxylate, alkyl phosphate, alkyl glucoside, polyether-modified silicone, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, amidoamine, dialkyldimethylammonium chloride dimethylacetate betaine, alkylamidopropyl betaine, alkylcarboxymethylhydroxyethyl Imidazolinium betaine, lecithin (soybean or egg yolk) and its derivatives, propylene glycol fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxy Propylene alkyl ethers, polyoxyethylene alkyl nonylphenyl ethers, polyoxyethylene alkyl ether phosphates/phosphates, sucrose fatty acid esters, etc., may be used alone or in combination of two or more thereof. .

(wetting agent)
Wetting agents include, for example, glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, polyethylene glycol, 1,2-pentanediol, 1,3-hexanediol, propylene glycol, dipropylene glycol, isopropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, maltitol, reduced starch syrup, lactitol, palatinit, erythritol, sorbitol, mannitol, xylitol, xylose, trehalose, glycoside trehalose, glucose, glucose, lactose, mannose, maltose, fructose, inositol, pentaerythritol, maltotriose, starch-decomposing sugar, starch-decomposing sugar reducing alcohol, ethylene oxide, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, propylene oxide, water-soluble proteoglycan, collagen, ceramide etc., and among these, one or more of them can be used in combination.

(Polymer compound)
A polymer compound other than the component B may be included.
Polymer compounds include, for example, sodium alginate, carrageenan, agar, furcelleran, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, arabic gum, gutti gum, karaya gum, tragacanth gum, and arabinogalactan. , pectin, quince, wheat protein, soy protein, albumin, casein, gelatin, chitosan, hyaluronic acid, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, crystalline cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, Hydroxypropylmethylcellulose, carboxymethylcellulose, cationized cellulose, cationized guar gum, hydroxypropylated guar gum, carboxyvinyl polymer, polyacrylic acid amide, sodium polyacrylate, polyethyleneimine, highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, and the like. Among these, one type or two or more types can be used in combination.

(animal and plant extracts)
Examples of animal and plant extracts include placenta extract, hydrolyzed keratin, hydrolyzed silk, yeast extract, aloe extract, comfrey extract, peony extract, perilla extract, sage extract, assembly extract, hamamelis water, cypress extract, hop extract, horse chestnut extract. extract, peach leaf extract, saxifrage extract, melissa extract, mugwort extract, rosemary extract, fermented rice bran extract and the like, and among these, one or more of them can be used in combination.

(amino acids)
Examples of amino acids include L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-asparagine, L-cysteine, L-serine, L-tyrosine, L-proline, pyrrolidone carboxylate, glycine. , valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, cystine, hydroxyproline, hydroxylysine, ornithine, histidine, γ-aminobutyric acid, ε-aminocaproic acid, etc., of which one or Two or more kinds can be used in combination.

(solvent)
Examples of the solvent include purified water and ordinary water, and among these, one or more of them can be used in combination.

(Anti-inflammatory agent)
Antiphlogistic agents include, for example, glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, guaiazulene, sodium guaiazulene sulfonate, allantoin, ε-aminocaproic acid, and tranexamic acid. , can be used alone or in combination of two or more.

(Preservative)
Examples of antiseptics include methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, bisabolol, hinokitiol, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate, undecylenic acid, pionin. , l-menthol, d-camphor, isopropylmethylphenol, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, ethylhexylglycerin and the like, and among these, one or more of them can be used in combination.

(UV inhibitor)
Examples of UV inhibitors include para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone sulfonate, and hydroxymethoxybenzophenone. sodium sulfonate, octyl salicylate, 4-tert-butyl-4′-methoxy-dibenzoylmethane, ferulic acid, titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide and the like, and among these, one or Two or more kinds can be used in combination.

(Sequestering agent)
Sequestering agents include, for example, edetic acid, edetate, ethylenediaminehydroxyethyltriacetate trisodium, diethylenetriaminepentaacetic acid, diethylenetriaminepentaacetic acid pentasodium, ethylenediaminetetrakis(2-hydroxyisopropyl)dioleate, hydroxyethanediphosphone. acid, tetrasodium hydroxyethanediphosphonate, phytic acid, and the like, and among these, one or more of them can be used in combination.

(Antioxidant)
Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, d-δ-tocopherol and the like, and among these, one or more of them can be used in combination. .

(pH adjuster)
Examples of pH adjusters include citric acid, glycolic acid, malic acid, tartaric acid, lactic acid, succinic acid, phosphoric acid and salts thereof, and among these, one or more of them may be used in combination. can.

(pigment)
Examples of organic pigments include azo pigments and phthalocyanine pigments, and laked ones are also used. Examples of organic pigments include organic pigment powders such as Red No. 201, Red No. 202, Red No. 205, Red No. 226, Red No. 228, Orange No. 203, Orange No. 204, Blue No. 404 and Yellow No. 401, and Red No. 3. , Red No. 104, Red No. 106, Orange No. 205, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, zirconium, barium or aluminum lakes, etc., and inorganic pigments such as silicic anhydride, magnesium silicate , talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjo, chromium oxide, water Chromium oxide, carbon black, calamine, cerium oxide, barium sulfate iron oxide, Prussian blue and the like.

Although the disinfecting composition of the present invention has been described above, the present invention is not limited thereto.

Next, specific examples of the present invention will be described.
<Production of disinfecting composition>
(Examples 1 to 9, Comparative Examples 1 to 9)
Using the ingredients and blending amounts shown in Tables 1 and 2, a cream-like disinfecting composition was produced according to a conventional method.
In Tables 1 and 2, hydrophobized HPMC indicates stearoxyhydroxypropyl methylcellulose. Polyglyceryl-5 stearate was used as polyglyceryl monostearate.

<Evaluation>
(Evaluation of moisture retention after rinsing with soap)
It was evaluated according to the following procedures.
(1) The stratum corneum water content (initial value) of the inner part of the forearm of two sensory evaluators was measured.
(2) 15 mg of the disinfecting composition of each example and each comparative example was applied.
(3) After 3 hours, the water content of the keratin was measured after rinsing with soap.
(4) The change in keratin moisture content from the initial value was converted into a percentage, and the average value of two persons was evaluated according to the following evaluation criteria.
A: Initial is 250% or more B: Initial is 200% or more and less than 250% C: Initial is 140% or more and less than 200% D: Initial is 135% or more and less than 140% E: Initial is less than 135%

(Evaluation of bactericidal effect)
Escherichia coli (Escherichia coli NBRC3972) was precultured in SCD medium at 32.5°C for 24 hours to obtain a culture solution. After diluting the obtained culture solution with physiological saline so that the number of bacteria was 10 ⁸ CFU/mL, 1/100 amount of the culture solution prepared for 20 g of the disinfecting composition of each example and each comparative example was added. was added and mixed to obtain a mixture. After 3 minutes, 1 mL of each resulting mixture was serially diluted with 9 mL of LP diluent to obtain diluted solutions. 1 mL of each diluted solution thus obtained was mixed with a TSA medium, and the number of viable cells was determined by the pour culture method. Here, in the pour culture method, the sample solution and agar medium are mixed and solidified in a petri dish, cultured at 32.5 ° C. under aerobic conditions, and the number of colonies generated after culture is visually measured, and the multiplier was multiplied by the number of viable bacteria. Based on the number of viable bacteria, evaluation was made according to the following evaluation criteria.
A: Less than 1.0×10 ² CFU/mL B: 1.0×10 ² CFU/mL or more and less than 1.0×10 ³ CFU/mL C: 1.0×10 ³ CFU/mL or more 5.0× Less than 10 ³ CFU/mL D: 5.0 × 10 ³ CFU/mL or more and less than 1.0 × 10 ⁴ CFU/mL E: 1.0 × 10 ⁴ CFU/mL or more

(Evaluation of stability)
After storing the disinfecting composition of each example and each comparative example at 40° C. for one month, the stability was evaluated by visual judgment according to the following criteria.
A: Not separated at all, uniform B: Slightly separated, but almost uniform C: Slightly separated, slightly non-uniform D: Slightly separated, non-uniform is in a good state.
E: Completely separated and in a heterogeneous state

(Evaluation of usability)
The disinfecting compositions of each example and each comparative example were evaluated for "good spreadability", "no stickiness", and "balance between hardness and finger rubbing" according to the following evaluation criteria.
A: Good B: Somewhat good C: Neither D: Somewhat bad E: Bad

(comprehensive evaluation)
Evaluation was made according to the following evaluation criteria from the four evaluation items of "Evaluation of moisturizing after rinsing with soap", "Evaluation of bactericidal effect", "Evaluation of stability" and "Evaluation of feeling in use".
A: No E and 3 or more A B: No E and 2 A C: No E and 1 A D: No E and no A E: E These results are shown in Table 1.

As can be seen from Tables 1 and 2, the antiseptic composition of the present invention has excellent moisturizing properties even after rinsing with soap, excellent bactericidal effect, excellent stability of the formulation, and excellent usability, and is overall excellent. there were. On the other hand, in the comparative examples, satisfactory results were not obtained. In particular, in Comparative Example 8 containing ethanol, no long-lasting moisturizing effect was obtained. Further, in Comparative Examples 1 to 3, in which the component A ester oil was not used or contained in a small amount, the durability of the moisturizing effect after rinsing with soap was not sufficient. In addition, in Comparative Example 4 in which the hydrophobized hydroxyalkyl cellulose, which is the component B, was not used, the bactericidal effect was inhibited by the thickening component, and a sufficient bactericidal effect was not obtained. Moreover, in Comparative Example 6, in which the cationic fungicide that is component C was not used, a sufficient fungicidal effect was not obtained.

Claims (7)

Component A: Ester oil, Component B: Hydrophobized hydroxyalkyl cellulose, Component C: Cationic fungicide,
does not contain ethanol
The content of the component A is 0.1 to 40% by mass,
The content of the component B is 0.01 to 15% by mass,
A disinfecting composition, wherein the content of component C is 0.001 to 1% by mass. The disinfecting composition according to claim 1, wherein the content of component B is 1/4000 parts by mass or more and 150 parts by mass or less when the content of component A is 1 part by mass. The disinfecting composition according to claim 1 or 2, wherein the component A is at least one selected from the group consisting of isopropyl palmitate, isopropyl myristate, isotridecyl isononanoate, and cetyl 2-ethylhexanoate. The disinfecting composition according to any one of claims 1 to 3, wherein said C component is benzalkonium chloride and/or benzethonium chloride. 5. The disinfecting composition according to any one of claims 1 to 4, comprising a glycerin fatty acid ester as component D. The disinfecting composition according to claim 5, wherein the content of component D is 1/4000 parts by mass or more and 150 parts by mass or less when the content of component A is 1 part by mass. 7. A disinfecting composition according to any one of claims 1 to 6, which is a cream formulation.