KR20160068302A - Antibacterial or conservative composition containing polyglycerine-3 - Google Patents

Abstract

The present invention relates to an antibacterial or preserving composition containing polyglycerin-3 as a preserved agent. The antibacterial or preserving composition according to the present invention has excellent resistance against microorganisms by comprising the polyglycerin-3, has no skin side-effects, and has excellent skin moisturizing ability.

Description

ANTIBACTERIAL OR CONSERVATIVE COMPOSITION CONTAINING POLYGLYCERINE-3 "

The present invention relates to an antibacterial or preservative composition containing a specific glycerin derivative and excellent in antibacterial and repellent properties.

Various products such as cosmetics and human body products are suitable for growing microorganisms because they contain various materials such as moisturizing agent, oil, surfactant, inorganic powder, organic water-soluble polymer, and perfume. Therefore, it is common to add a chemical preservative in order to prevent the product from being corrupted by the microorganism, to kill the microorganism over time and to prevent deterioration of the product. As such chemical preservatives, parabens, imidazolidinyl urea, phenoxyethanol, paraoxybenzoic acid esters, or benzalkonium chloride are generally used.

However, recently, new additives such as proteins, gums, vitamins and medicinal plants have been added to the product, and the changes due to the action of microorganisms have also become diverse, and the effect of the chemical preservatives has weakened and the content of chemical preservatives has been increasing. As the content of the chemical preservative is increased, there arises a problem of toxicity such as irritation to the skin, allergic symptoms, and the like.

Therefore, there is a need for new products that do not contain a chemical preservative or contain a low content, but which are not spoiled by microorganisms.

The present invention is not only excellent in antibacterial and repellency even when a chemical preservative is not used or in a small amount, but also can achieve a moisturizing effect without being tacky, and is excellent in stability of a formulation, It is an object of the present invention to provide an antibacterial or preservative composition free from skin side effects.

The present invention provides an antimicrobial or preservative composition comprising a compound represented by the following formula (1).

[Chemical Formula 1]

In order to solve the problems of the prior art, the present inventors have tested various components, and polyglycerin-3 of the above-mentioned formula (1) has been able to achieve antibacterial and antiseptic effects.

As a result, it has been found that by using polyglycerin-3, a chemical preservative can not be used or its content can be reduced, skin side effects do not occur, and besides antibacterial and antiseptic effects, moisturizing effect can be achieved without stickiness. .

The antimicrobial or preservative composition according to the present invention contains polyglycerin-3 so that it has excellent resistance to microorganisms even when used with or without a chemical preservative, and is excellent in moisture retention and does not cause skin side effects.

The present invention relates to an antimicrobial or preservative composition comprising polyglycerin-3 of formula (1).

[Chemical Formula 1]

Hereinafter, the antimicrobial or preservative composition according to the present invention will be described in more detail.

In the present invention, the term "antibacterial" means the ability to resist bacteria and means all mechanisms that are performed to defend against the action of microorganisms such as bacteria or fungi.

In the present invention, the term "bacterium" is a bacterium belonging to bacteria. It is the most prolific species among living organisms, and most of them are pathogenic bacteria, but they do not have nucleus, mitochondria and chloroplast. Sizes range from 0.5 μm to 0.5 mm. Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, and Escherichia coli ATCC 10536 may be used as the bacterium. For example, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, and Escherichia coli ATCC 10536 may be used.

The term "fungus" in the present invention refers to a group of microorganisms consisting of more than 72,000 species including fungi, yeast, and mushroom. It belongs to eukaryotes with nuclear membrane, and mitochondria and endoplasmic reticulum are developed, Chitin, and glucan. Most of them are characterized by the formation of cell-grown mycelium to elongate, develop, sexual reproduction and asexual reproduction. Spores are formed in the form of reproductive sperm but some of the species are unicellular. It is mainly a negative bacterium, but it is involved in the organic decomposition of nature, but some parasitism or symbiosis with plants and animals. As the fungi, for example, Aspergillus niger ATCC 9642 and Candida albicans ATCC 10231 can be used.

In the present invention, polyglycerin-3 is used as a preservative and can exhibit excellent antibacterial and antiseptic effects.

The content of the polyglycerin-3 may be 0.01 to 40% by weight or 1 to 10% by weight based on the total weight of the total composition. It has excellent antimicrobial and preservative effect in the above content range. If the content of the polyglycerol-3 is less than 0.01% by weight, it does not greatly contribute to the antibacterial and antiseptic effect, and if it exceeds 40% by weight, the feeling of use may become sticky.

The antimicrobial or preservative composition of the present invention may further contain a chemical preservative in addition to polyglycerin-3.

Polyglycerin-3 is used together with a chemical preservative to produce synergistic effects and to exhibit even better antimicrobial and preservative effects. Specifically, since the polyglycerin-3 exhibits excellent antibacterial and antiseptic effects, excellent antimicrobial and antiseptic effects can be exhibited even when a small amount of a chemical preservative is used. Thus, unlike conventional cosmetic compositions that use excessive amounts of chemical preservatives cause skin irritation and skin adverse effects such as allergies, the antimicrobial or preservative compositions of the present invention scarcely cause side effects such as skin irritation and allergies.

Examples of the chemical preservative include polyols such as 3-hexyloxy-1,2-propanediol, 1,2-hexanediol, and octanediol, parabens such as methylparaben, ethylparaben, And phenoxyethanol, or a mixture of two or more thereof.

The amount of the chemical preservative may be 0.01 to 30% by weight, 0.1 to 10% by weight or 0.5 to 5% by weight based on the total weight of the composition. The synergistic effect with polyglycerin-3 is excellent in the above range, and if it exceeds 30% by weight, skin side effects such as skin irritation and allergy may occur.

As described above, the present invention provides an antimicrobial or preservative composition containing polyglycerin-3 of Chemical Formula 1 and having excellent antibacterial and repellency. Such antimicrobial or preservative compositions can be used for cosmetics, quasi-drugs, medicines or preservatives.

In one aspect, the present invention can provide a cosmetic composition comprising an antimicrobial or preservative composition according to the present invention. In the present invention, the cosmetic composition contains polyglycerin-3, thereby improving not only the antibacterial activity but also the stability.

The polyglycerin-3 contained as an active ingredient is a colorless and transparent liquid and is excellent in stability of a cosmetic composition because it is excellent in solubilization ability and emulsion stabilization ability as compared with a conventional moisturizer. However, the effect of stabilizing the composition of the polyglycerin-3 of the present invention is not limited to the above theoretical assumption. Accordingly, the polyglycerin-3 according to the present invention can be used as an oil-in-water or water-in-oil type cosmetic composition, emulsion, microemulsion, skin, lotion, cream, foundation, essence, gel, pack, foam cleanser, softening liquor, The present invention can be used for improving the stability of various formulations such as liners, shampoos, rinses, soaps, body cleansers, correctives, and hair formers, but the present invention is not limited to these formulations.

The present invention provides a method for improving the stability of a cosmetic composition characterized by adding polyglycerin-3 to a cosmetic composition. The polyglycerin-3 may be used as a moisturizer.

Preferably, the present invention is characterized in that it comprises water of 1-60 wt.%, Water-moisturizer of 1-10 wt.%, Surfactant of 0.1-5 wt.%, Oil of 0.1-30 wt.%, And a water-in-oil type cosmetic composition.

In the cosmetic composition with improved stability according to the present invention, as the moisturizing agent, in addition to polyglycerin-3 according to the present invention, propylene glycol, 1,3-butylene glycol, dipropylene glycol , Glycols such as polyethylene glycol; Glycerol such as glycerin and diglycerin; Sugars such as sorbitol, multitol, sucrose, starch sugar, and raquitiol; Hyaluronic acid; Water-soluble ingredients such as betaine may be further used. However, it is preferable that the humectant is polyglycerin-3 of the above formula (1) for the purpose of the present invention. Such a moisturizing agent enhances the moisturizing ability of the skin and lowers the polarity of the water, and low wax, high alcohol, surfactant and the like interact with the water phase to help form a stable emulsion.

The cosmetic composition with improved stability of the present invention may further contain a higher alcohol, a wax, a flavoring agent, a coloring agent and the like within the range not hindering the object of the present invention, Can be selected and used.

In another aspect, the present invention can provide a quasi-drug composition comprising an antibacterial or preservative composition according to the present invention. That is, the composition of the present invention can be added to a quasi-drug composition which requires antibacterial or preservation.

When the composition of the present invention is used as an additive, the composition may be added as it is or may be used together with other quasi-drugs or quasi-drugs, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient can be appropriately determined depending on the purpose of use.

The quasi-drug composition may be, for example, disinfectant cleaner, shower foam, gagrin, wet tissue, detergent soap, hand wash, humidifier filler, mask, ointment agent, coating agent or filter filler.

In another aspect, the present invention can provide a pharmaceutical composition comprising an antimicrobial or preservative composition according to the present invention.

The pharmaceutical composition of the present invention may be formulated in the form of tablets, pills, powders, capsules, suspensions, oral solutions, emulsions or syrups, oral preparations, suppositories or injection solutions according to a conventional method have. In detail, when formulated, it can be prepared by using diluents or excipients such as fillers, weighing agents, binders, wetting agents, disintegrants, surfactants and the like which are generally used. Solid formulations for oral administration include, but are not limited to, tablets, pills, powders, granules, capsules, and the like. Such a solid preparation may be prepared by mixing at least one excipient such as starch, calcium carbonate, sucrose, lactose, gelatin and the like in addition to the polyglycerin-3 of Formula 1 above.

In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral administration, liquid paraffin, and various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like. Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations and suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, injectable esters such as ethyl oleate, and the like. Examples of the suppository base include withexol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.

The composition of the present invention may be administered orally or parenterally (for example, intravenously, subcutaneously, intraperitoneally or topically) depending on the desired method, and the dose may be determined depending on the condition and weight of the patient, The mode of administration, the route of administration, and the time, but may be suitably selected by those skilled in the art.

In another aspect, the present invention can provide a preservative composition comprising an antimicrobial or preservative composition according to the present invention.

The preservative composition may be used in an appropriate amount depending on the kind of the product containing the preservative composition and the intended use. For example, it is possible to add acetic acid, sodium acetate, sorbic acid, benzoic acid and propionic acid. It is emulsified with natural emulsifier such as natural linseed oil soap, propolis soap and acacia sap, Powder, etc. can be freely manufactured and supplied.

Hereinafter, the present invention will be described in detail with reference to examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Reference Example  One: Polyglycerin -3 Material Information

[Chemical Formula 1]

Compound name: polyglycerin-3;

         3- [3- (2,3-dihydroxypropoxy) -2-hydroxypropoxy] propane-1,2-diol

CAS No .: 56090-54-1

≪ Comparative Example and Example 1-4 >

An emulsion type antibacterial or preservative cosmetic composition was prepared by a conventional method using the composition components and contents shown in Table 1 below.

Ingredients Ingredients Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Polyglycerin-3 - 2,000 2.000 4.000 6.000 Purified water To 100 To 100 To 100 To 100 To 100 glycerin 4.000 4.000 4.000 4.000 4.000 1,2-hexanediol 0.500 - 0.500 0.500 0.500 Panthenol 0.500 0.500 0.500 0.500 0.500 Tree sodium 0.002 0.002 0.002 0.002 0.002 Wax 0.500 0.500 0.500 0.500 0.500 PIGGY-40 Hydrogenated Castor Oil 0.300 0.300 0.300 0.300 0.300 Xanthan gum 0.030 0.030 0.030 0.030 0.030 incense Q.S Q.S Q.S Q.S Q.S Methyl paraben 0.200 -  - - - Ethyl paraben 0.100 - - - - Propylparaben 0.100 - - - -

<Experimental Example 1>

To test the antimicrobial and preservative effects of the compositions of Comparative Example 1 and Examples 1 to 4, bacteria or fungi were added to the samples and the change of inoculum number was checked. When the number of fungi or bacteria was less than 20 CFU / g The starting date was recorded and is shown in Table 2 below. The test was conducted up to 28 days. The test procedure is as follows.

First, 40 g of the cosmetic composition was contained, and then the bacteria, that is, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, Escherichia coli ATCC 10536, Were added to the samples to give a total of 106 tablets per 1 g of the sample, mixed and stored for 4 weeks. Then, the number of inoculated bacteria was checked every 1 day, 7 days, 14 days, 21 days, 28 days from the day of inoculation.

The test procedure using fungi was the same as the test using bacteria, and Aspergillus niger ATCC 9642 and Candida albicans ATCC 10231 were used as fungi.

Evaluation items
Comparative Example Example One One 2 3 4 Germ 14 days 14 days 7 days 3 days 1 day Fungus 14 days 14 days 7 days 3 days 1 day

As shown in Table 2, in the case of the comparative example, the number of fungi or bacteria was 20 CFU / g or less from the 14th day using a chemical preservative.

On the other hand, Example 1 of the present invention showed the number of fungi or bacteria of 20 CFU / g or less from the 14th day even though no chemical preservative was used, and the antibacterial and preservative effect similar to that of Comparative Example 1 using a chemical preservative Was found. In particular, in the case of Examples 3 and 4 containing 4% by weight or more of polyglycerin-3, the number of fungi and bacteria was sharply reduced and the number of fungi or bacteria was 20 CFU / g or less from day 3 and day 1 respectively The antimicrobial and preservative effect was far superior to the comparative example containing the chemical preservative. This shows that the synergistic effect of polyglycerin-3 and 1,2-hexanediol showed very excellent antibacterial and antiseptic effects.

&Lt; Test Example 2 &

In order to evaluate the skin irritation of Example 4 and Comparative Example 1, the first stimulation test was performed on the human body through the human patch test according to the following method.

The stimulation test was conducted on 50 healthy adults aged 50 years. The CTFA guidelines [References: The Cosmetic, Toility and FragranceAssociation. Inc. Washington, D.C., 2003 June 1994). 15 mL of the sample and solution was dropped into a Finn chamber, and the sample was placed on the back of the human body to be tested and fixed with a tape. After 24 hours, the patches were removed. After 4 hours, the skin reaction of the test site was judged according to the following criteria, and the results are shown in Table 3 below.

<Criteria>

-: No erythema or unusual phenomenon

+/-: Slightly redder than surrounding

+: Significantly reddened than surrounding

++: More reddening and swelling than the surrounding area

Number of stimuli = [{(+/-) number x 1} + {(+) number x 2} + {(++) number x 3}

sample Tested embroidery Judgment result Irritation degree ++ + +/- - Example 4 50 0 0 3 47 0.06 Comparative Example 1 50 0 3 4 43 0.20

As shown in Table 3, in Example 4 using polyglycerin-3, skin irritation was significantly reduced as compared with Comparative Example 1 using a chemical preservative.

Claims (9)

3. A composition for antibacterial or antimicrobial preservation comprising polyglycerin-3 of the formula (1).
[Chemical Formula 1]

The method according to claim 1,
Wherein the polyglycerin-3 is contained in an amount of 0.01 to 40% by weight based on the total weight of the composition.
The method according to claim 1,
A composition for antimicrobial or preservation, which further comprises a chemical preservative.
The method of claim 3,
The chemical preservative may further comprise one or more selected from the group consisting of 3-hexyloxy-1,2-propanediol, 1,2-hexanediol, octanediol, paraben and phenoxyethanol, Composition.
The method of claim 3,
Wherein the chemical preservative is included in an amount of 0.01 to 30% by weight based on the total weight of the composition.
A cosmetic composition comprising the antibacterial or preservative composition according to claim 1.
A quasi-drug composition comprising the antibacterial or preservative composition of claim 1.
A pharmaceutical composition comprising the antimicrobial or preservative composition of claim 1.
A preservative composition comprising the antimicrobial or preservative composition of claim 1.