JP6230502B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition.

  Allantoin and its derivatives are known to be useful active ingredients that activate cell functions and have anti-inflammatory and anti-ulcer effects.

  On the other hand, allantoin and its derivatives have the property of being easily hydrolyzed, so that their stability is extremely poor. For this reason, various studies have been made to improve the stability of allantoin and its derivatives in each field.

  For example, Patent Document 1 discloses that in an aqueous preparation containing allantoin, an organic acid or inorganic acid, an amino acid, an alkali metal salt thereof, or a combination of two or more thereof can stably add allantoin to an aqueous base. Have been described. In Patent Document 2, in a liquid oral composition containing allantoin, the combination of citric acid and citrate, citric acid and alkaline agent, or citrate and acid has an allantoin hydrolysis inhibiting effect during high-temperature storage. It is described that it has. Patent Document 3 describes that, in a composition for transparent liquid oral cavity containing allantoin, the pH can be maintained in a pH range that maintains the stability of allantoin by blending lactic acid.

  On the other hand, a dentifrice used for the purpose of cleaning the oral cavity by placing it on an applicator such as a toothbrush requires moderate viscosity and needs to suppress the solidification of the paste, and thus a viscous agent such as sorbitol has been blended. .

JP-A 63-159317 JP 2010-143889 A JP20131651A

  However, when allantoin or a derivative thereof is added to a dentifrice, even if an acid is added to adjust the pH of the dentifrice, as in the aqueous preparations and solutions described in Patent Documents 1 to 3, the stability of allantoin or a derivative thereof is improved. Sex was not improved sufficiently and the cause was unknown.

  The inventors of the present invention have made extensive studies to solve the above problems, and have found that the inclusion of a specific amount of sorbitol affects the stability of allantoin. However, it has been found that when potassium nitrate is further added to the system, precipitates are formed during low-temperature storage and the low-temperature stability is impaired.

  Moreover, if the sorbitol content is lowered in order to suppress precipitation of potassium nitrate, allantoin and / or its derivatives are hydrolyzed. Therefore, there has been a demand for a technique that can ensure both the stability of allantoin and / or its derivatives and the suppression of precipitation of potassium nitrate.

  An object of the present invention is to provide a dentifrice composition that is compatible with ensuring the stability of allantoin and / or its derivatives and suppressing precipitation of potassium nitrate.

  As a result of intensive studies to solve the above problems, the inventors of the present invention include a specific thickener in a specific amount range in a dentifrice composition containing allantoin and / or a derivative thereof and potassium nitrate. As a result, the inventors have found that the above problems can be solved, and have completed the present invention.

The present invention provides the following.
Component (A): allantoin and / or a derivative thereof,
Component (B): potassium nitrate,
Component (C): glycerin, and component (D): sorbitol,
The dentifrice composition whose content of a component (C) is 20 mass%-45 mass% with respect to the total mass of a dentifrice composition, and whose content of a component (D) is 10 mass%-32 mass%.

  ADVANTAGE OF THE INVENTION According to this invention, the dentifrice composition in which the ensuring of stability of allantoin and / or its derivative and the precipitation suppression of potassium nitrate were compatible was provided.

  The dentifrice composition of the present invention contains components (A) to (D). Each component will be sequentially described below.

[Component (A)]
Component (A) is allantoin and / or a derivative thereof.

  Examples of allantoin derivatives include allantoinchlorohydroxyaluminum and allantoindihydroxyaluminum.

  It is preferable that content of the component (A) in the dentifrice composition of this invention is 0.01 mass% or more with respect to the dentifrice composition total mass. Thereby, a periodontal disease disease inhibitory effect can fully be expressed.

  Although there is no restriction | limiting in particular in the upper limit of content of a component (A), It is preferable that it is 0.5 mass% or less with respect to the dentifrice composition total mass. Thereby, the occurrence of astringency can be suppressed.

  In addition, in this invention, content of each component in a dentifrice composition is based on the preparation amount of each component at the time of manufacturing a composition unless there is particular notice.

[Component (B)]
Component (B) is potassium nitrate.

  Content of the component (B) in the dentifrice composition of this invention becomes like this. Preferably it is 1 mass% or more with respect to the dentifrice composition total mass, More preferably, it is 3 mass% or more. If it is less than 1% by mass, the hypersensitivity suppressing effect may be reduced.

  The upper limit of the content of component (B) is preferably 10% by mass or less, more preferably 7% by mass or less, with respect to the total mass of the dentifrice composition. If it exceeds 10% by mass, potassium nitrate may be precipitated.

[Component (C)]
Component (C) is glycerin.

  Content of the component (C) in the dentifrice composition of this invention is 20 mass% or more with respect to the dentifrice composition total mass, Preferably it is 25 mass% or more, More preferably, it is 30 mass% or more. . Thereby, the stabilization effect of a component (A) can fully be acquired.

  The upper limit of content of a component (C) is 45 mass% or less with respect to the dentifrice composition total mass, Preferably it is 35 mass% or less. Thereby, spinnability can be suppressed and precipitation of a component (B) can be suppressed.

[Component (D)]
Ingredient (D) is sorbitol.

  Content of the component (D) in the dentifrice composition of this invention is 10 mass% or more with respect to the dentifrice composition total mass, Preferably it is 20 mass% or more, More preferably, it is 25 mass% or more. . Thereby, the precipitation inhibitory effect of a component (B) and the stabilization effect of a component (A) can fully be acquired.

  The upper limit of content of a component (D) is 32 mass% or less with respect to the dentifrice composition total mass, Preferably it is 30 mass% or less. Thereby, the stabilization effect of a component (A) can fully be acquired.

[Component (C) / Component (D)]
The ratio of the content of component (C) to the content of component (D) (hereinafter abbreviated as component (C) / component (D)) is preferably 0.5 to 5, Is more preferable, and it is still more preferable that it is 1-2. Thereby, the stabilization effect of a component (A) and the precipitation inhibitory effect of a component (B) can be acquired more fully.

[Other ingredients]
The dentifrice composition of the present invention comprises, in addition to the above-mentioned components, an additive component (pharmacologically or cosmetically acceptable carrier) that can be used in the dentifrice composition within a range that does not impair the effects of the present invention. You may contain. Examples of such additional components include abrasives, binders, thickeners (wetting agents) other than components (C) and (D), surfactants, sweeteners, preservatives, fragrances, colorants, and components ( A medicinal component other than A) and (B), a pH adjuster, and a solvent are mentioned, and can be appropriately selected according to the dosage form. Although the specific example of an additional component is described below, the component which the dentifrice composition of this invention may contain is not restrict | limited to these.

  Examples of the abrasive include silica-based abrasives such as silicic anhydride, crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, calcium hydrogen phosphate, calcium hydrogen phosphate anhydrous, calcium hydrogen phosphate. Examples thereof include dihydrate, calcium pyrophosphate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasive. Of these, anhydrous silicic acid and calcium hydrogen phosphate are preferred, and anhydrous silicic acid is more preferred.

  The amount of silicic acid absorbed is usually preferably in the range of 0.5 mL / g to 2.0 mL / g, more preferably 0.7 mL / g to 1.5 mL / g. When a material in this range is used, a higher polishing effect can be obtained.

  In the present invention, the liquid absorption is a value measured by the following method. That is, 1 g of a sample is weighed on a glass plate, and mixed with a spatula while the 42.5 mass% glycerin aqueous solution is dropped using a burette. The end point is when the sample becomes one lump and can be removed from the glass plate with a spatula, and the amount of glycerin aqueous solution required for 1.0 g of the sample is expressed as the liquid absorption amount (mL / g).

  The said abrasive | polishing agent can be used individually by 1 type or in combination of 2 or more types. When mix | blending an abrasive | polishing agent, it is preferable that the compounding quantity is 5 mass%-30 mass% with respect to dentifrice composition total mass, and it is more preferable that it is 5 mass%-20 mass%.

  Examples of the binder include organic binders and inorganic binders, and one or a combination of two or more selected from these may be used.

  Examples of organic binders include sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, sodium alginate, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, propylene glycol alginate, pullulan, gelatin, hydroxypropylcellulose, gum arabic , Guar gum, locust bean gum, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, and the like. Examples of the inorganic binder include thickening silicic anhydride and bentonite. In addition, it is preferable that it is 1.5 mL / g or more, and, as for the liquid absorption amount of thickening silicic anhydride, it is more preferable that it is 1.5 mL / g-3 mL / g.

  The organic binder may be one type or a combination of two or more types. One kind of inorganic binder may be used, or a combination of two or more kinds may be used. The binder is preferably a combination of an organic binder and an inorganic binder.

  When using an organic binder, the content thereof is usually 0.5% by mass to 3% by mass with respect to the total mass of the dentifrice composition. When using an inorganic binder, the content thereof is preferably 1 to 10% by mass, more preferably 1 to 7% by mass, and still more preferably 2 to 6% by mass. Thereby, the usability as a dentifrice composition improves.

  Examples of other thickening agents (wetting agents) other than (C) and (D) include sugar alcohols such as xylitol, maltitol, and erythritol; ethylene glycol, propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, and the like. A polyhydric alcohol is mentioned. Other viscous agents can be used alone or in combination of two or more. The total content (including C and D) of the viscous agent can be determined within a range not impeding the effects of the present invention, and is usually 30 to 80% by mass with respect to the total mass of the dentifrice composition.

  As the surfactant, for example, an anionic surfactant, a nonionic surfactant, an amphoteric surfactant and the like can be used.

  Examples of the anionic surfactant include N-acyl amino acid salts, α-olefin sulfonates, N-acyl sulfonates, alkyl sulfates, sulfates of glycerol fatty acid esters, and the like. Among these, N-acylamino acid salts, α-olefin sulfonates, alkyl sulfates and the like are preferable in terms of versatility, and lauroyl sarcosine sodium, sodium lauryl sulfate, sodium lauroyl methyl taurate in terms of taste and foaming properties. More preferred is sodium lauroyl glutamate.

  Nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, glycerin ester polyoxyethylene ether, sucrose fatty acid ester, alkyl glucoside, Examples include fatty acid alkylolamide and glycerin fatty acid ester. Of these, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, fatty acid alkylolamide, sorbitan fatty acid ester and the like are preferably used from the viewpoint of versatility. The polyoxyethylene alkyl ether preferably has a carbon chain length of 12 to 18 carbon atoms. The polyoxyethylene alkyl ether preferably has an average ethylene oxide addition mole number of 3 to 30. The polyoxyethylene hydrogenated castor oil preferably has an ethylene oxide average addition mole number (average addition EO) of 20 to 100. The fatty acid alkylolamide preferably has an alkyl chain with a carbon chain length of 12 to 14 carbon atoms. The sorbitan fatty acid ester preferably has 12 to 18 carbon atoms in the fatty acid. The polyoxyethylene sorbitan fatty acid ester preferably has 16 to 18 carbon atoms in the fatty acid. In addition, the polyoxyethylene sorbitan fatty acid ester preferably has an average ethylene oxide addition mole number of 10 to 40.

  Examples of amphoteric surfactants include alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples of the amphoteric surfactant include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and coconut oil fatty acid amide alkylbetaine, and coconut oil fatty acid amidopropyl betaine is preferred.

  The surfactant may be used alone or in combination of two or more. When a dentifrice composition contains surfactant, it is preferable that the content is 0.01 mass%-10 mass% with respect to the dentifrice composition total mass.

  Examples of the sweetening agent include saccharin sodium, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, thaumatin, palatinose, maltitol, xylitol, arabitol and the like. One sweetener may be used alone, or two or more sweeteners may be used in combination. When using a sweetener, content can be suitably determined in the range which does not impair the effect of this invention.

  Examples of the preservative include paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, and butylparaben, ethylenediaminetetraacetate, benzalkonium chloride, and the like. One preservative may be used alone, or two or more preservatives may be used in combination. In the case of using a preservative, the content can be appropriately determined within a range not impairing the effects of the present invention.

  As a fragrance | flavor, the normal fragrance | flavor component which can be used for a formulation for oral cavity can be used individually or as a fragrance | flavor composition which combined multiple. It is preferable that content of a fragrance | flavor is 0.00001 mass%-3 mass% with respect to the dentifrice composition total mass.

  Examples of the colorant include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red potato pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina pigment, and coumarindo pigment. Red 3, No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and other legal dyes, riboflavin, copper chlorofin sodium, titanium oxide, titanium dioxide, etc. Is mentioned. When a dentifrice composition contains a coloring agent, it is preferable that the content is 0.00001 mass%-3 mass% with respect to the dentifrice composition total mass.

  Examples of the medicinal component include components other than components (A) and (B), that is, the following components: fluorides such as sodium monofluorophosphate, sodium fluoride, stannous fluoride, and strontium fluoride; Bactericidal or antibacterial agents such as chlorhexidine hydrochloride, triclosan, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride; condensed phosphates such as sodium pyrophosphate and sodium polyphosphate, zeolite, sodium monohydrogen phosphate and phosphorus Calculus preventives such as phosphates such as trisodium acid; anti-inflammatory agents such as tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, ε-aminocaproic acid, and buckwheat extract; astringents such as sodium chloride ; Lactic acid aluminum And hypersensitivity inhibitors such as strontium chloride; vitamins such as ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, tocopherol acetate, and the like. One medicinal component may be used alone, or two or more medicinal components may be used in combination. When using a medicinal component, the content can be appropriately set within a pharmaceutically acceptable range for each medicinal component.

  Examples of the solvent include lower alcohols having 3 or less carbon atoms such as ethanol and propanol. When a dentifrice composition contains a lower alcohol, it is preferable that the content is 1 mass%-20 mass% with respect to the dentifrice composition total mass.

  The pH (25 ° C.) of the dentifrice composition of the present invention is preferably 4 or more, more preferably 4.5 or more. Thereby, decalcification of teeth can be suppressed. The upper limit of pH is preferably 6.5 or less, and more preferably 6 or less. Thereby, the stabilization effect of a component (A) can be acquired more fully. Accordingly, the pH is preferably 4 to 6.5, and more preferably 4.5 to 6.5.

  The pH adjuster is not particularly limited, and examples of the acidic component include inorganic acids such as hydrochloric acid, sulfuric acid, and phosphoric acid, organic acids such as acetic acid, gluconic acid, citric acid, maleic acid, succinic acid, and glutamic acid, bases Examples of the sexual component include sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate and the like. Among these, an organic acid is preferably used as the acid, and citric acid is more preferably used. Moreover, when using an organic acid, it is preferable to use an organic acid salt in addition to the organic acid, and it is more preferable to combine citric acid and sodium citrate. When using a pH adjuster, the content can be suitably determined within a range not impairing the effects of the present invention.

  The dentifrice composition of the present invention usually contains water.

  The water content in the dentifrice composition of the present invention is 10% by mass or more, preferably 15% by mass or more, based on the total mass of the dentifrice composition.

  The upper limit of the water content in the dentifrice composition of the present invention is not particularly limited as long as it can be used as a dentifrice composition, but it is 50% by mass or less and 45% by mass with respect to the total mass of the dentifrice composition. Or less, more preferably 40% by mass or less.

  In addition, content of water means the total water content in a dentifrice composition.

  The dosage form of the dentifrice composition of the present invention is not particularly limited, and examples thereof include a paste form and a liquid form. The dentifrice composition prepared in the dosage form can be various dentifrice products such as toothpaste, liquid dentifrice, and gel-like dentifrice. The preferred product form of the present invention is a toothpaste.

  EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to such examples. In the following, “%” means “mass%” unless otherwise specified.

[Main raw materials used in Examples and Comparative Examples]
<Component (A)>
Allantoin (manufactured by Permachem Asia)
Allanto chlorohydroxyaluminum (manufactured by Permachem Asia Co., Ltd., trade name “ALCLOXA”)
Allanto dihydroxyaluminum (manufactured by Permachem Asia, trade name “Aldioxa”)

<Component (B)>
Potassium nitrate (Matsumoto Trading Co., Ltd.)

<Ingredient (C)>
85% glycerin (manufactured by Lion Chemical)

<Component (D)>
Sorbitol (Rocket)

  As for other additive components, outer standard products were used.

[Examples 3 and 5 to 8, Reference Examples 1, 2, 4, and 9 to 11 and Comparative Examples 1 to 4]
Using the above components, a toothpaste composition was prepared by the following preparation method according to the blending amount shown in Table 1. In addition, the compounding quantity of each component shown in Table 1 is the value (AI) converted into a pure part except for 85% glycerin and 70% sorbitol. The values (AI) in terms of pure content for 85% glycerin and 70% sorbitol are also shown in the table. The unit of each blending amount is mass%.

(Method for preparing toothpaste composition)
(1) Component (A), Component (B), Component (C) and / or (D) in purified water, sodium fluoride, sodium saccharin, citric acid, sodium citrate, anhydrous silicic acid (thickening), titanium oxide Were mixed and dissolved at room temperature (mixture X).
(2) Sodium carboxymethyl cellulose and sodium polyacrylate were dispersed in propylene glycol at room temperature (mixture Y). Titanium oxide and the mixture Y were added and mixed in the stirring mixture X (mixture Z).
(3) In the mixture Z, a fragrance, sodium lauryl sulfate, and anhydrous silicic acid (abrasive) are mixed at room temperature using a kneader (made by Ishiyama Kogyo), defoamed under reduced pressure (5.3 kPa), and dentifrice A composition was obtained.

  About the prepared toothpaste composition, according to the following procedure, the allantoin decomposition inhibitory effect in an oral cavity and potassium nitrate precipitation were evaluated. The evaluation results are shown in Table 1.

(Evaluation method of allantoin decomposition inhibitory effect)
About the toothpaste composition after 1-month storage at 50 degreeC, the allantoin density | concentration was measured using HPLC according to the following test conditions. The residual rate when the allantoin concentration immediately after the production of each sample was 100% was calculated, and the allantoin decomposition inhibitory effect was determined according to the following criteria.

<Test conditions>
Detector: UV absorption photometer (measurement wavelength: 210 nm)
Column: Inertsil NH ₂ (4.6 mmφ × 250 mm)
Column temperature: 35 ° C
Mobile phase: acetonitrile / phosphate buffer solution mixture (4: 1)
Phosphate buffer solution: 5.75 g of ammonium dihydrogen phosphate was dissolved in 750 mL of water, phosphoric acid was added to adjust to pH 2.5, and water was added to make 1,000 mL.

<Devices used>
Pump: JASCO Corporation PU-980
Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X
Detector: JASCO Corporation UV-970
Column thermostat: Senshu Scientific Co., Ltd. SCC-2100
Flow rate: 1 mL / min

<Criteria>
◎: 95% or more ○: 90% or more and less than 95% ×: less than 90%

(Confirmation method for suppression of precipitation of potassium nitrate)
The toothpaste composition after storage at -5 ° C for 1 month was taken out of the tube, and the appearance was visually evaluated.

<Criteria>
◎: No precipitation ○: Slight precipitation ×: Precipitation

Table 1 shows the following. The toothpaste compositions of Examples 3 and 5 to 8, Reference Examples 1, 2, 4 and 9 to 11 were excellent in all evaluations of the allantoin decomposition inhibiting effect and the potassium nitrate precipitation inhibiting. In contrast, component Comparative Example 1-2 purity terms content is greater 20 than mass%, or 45 wt% of (C), purity converted content of the component D is less than 10 wt%, or 32 wt% Comparative Examples 3 to 4, which are super, were inferior in allantoin decomposition inhibitory effect or potassium nitrate precipitation inhibitory effect.

  These results show that the dentifrice composition of the present invention has a component (A) stabilizing effect and a component (B) precipitation suppressing effect, and is excellent in usability.

[Example 12] Toothpaste A toothpaste composition having the following composition was prepared.
Allantoin 0.1%
Potassium nitrate 5%
85% glycerin 29%
70% sorbitol 29%
Tranexamic acid 0.05%
Isopropyl methylphenol 0.05%
Sodium carboxymethylcellulose 1.2%
Sodium polyacrylate 0.5%
Propylene glycol 3%
Sodium fluoride 0.21%
Sodium citrate 0.5%
Citric acid 0.6%
Saccharin sodium 0.18%
Silicic anhydride (thickening) 5%
Titanium oxide 0.1%
Fragrance 1.2%
Silicic anhydride (abrasive) 10%
Sodium lauryl sulfate 1.2%
Water balance 100.0% by mass
Total water content: 26% pH: 5.8

[Example 13] Toothpaste A toothpaste composition having the following composition was prepared.
Allantoin 0.1%
Potassium nitrate 5%
85% glycerin 29%
70% sorbitol 29%
Palm oil fatty acid amidopropyl betaine 1.2%
Monoammonium glycyrrhizinate 0.2%
Sodium carboxymethylcellulose 0.5%
Xanthan gum 1%
Propylene glycol 3%
Sodium fluoride 0.21%
Sodium citrate 0.5%
Citric acid 0.6%
Saccharin sodium 0.18%
Silicic anhydride (thickening) 5%
Titanium oxide 0.1%
Fragrance 1.2%
Silicic anhydride (abrasive) 10%
Water balance 100.0% by mass
Total water content: 26% pH: 5.7

[Example 14] Toothpaste composition A toothpaste composition having the following composition was prepared.
Allantoin 0.1%
Potassium nitrate 5%
85% glycerin 35%
70% Sorbitol 36%
Polyoxyethylene (20) hydrogenated castor oil 1.2%
Cetylpyridinium chloride 0.2%
Tocopherol acetate 0.1%
Dipotassium glycyrrhizinate 0.2%
Pyridoxine hydrochloride 0.02%
Xanthan gum 1.0%
Sodium alginate 0.5%
Propylene glycol 3%
Sodium fluoride 0.21%
Sodium citrate 0.5%
Citric acid 0.6%
Saccharin sodium 0.18%
Silicic anhydride (thickening) 5%
Titanium oxide 0.1%
Fragrance 1.2%
Silicic anhydride (abrasive) 9%
Sodium lauryl sulfate 1%
Water balance 100.0% by mass
Total water content: 16% pH: 5.7

  Said dentifrice composition was excellent in any evaluation of a component (A) stabilization effect and a component (B) precipitation inhibitory effect.

Claims (5)

Component (A): one or more selected from the group consisting of allantoin , allantoinchlorohydroxyaluminum, and allantoindihydroxyaluminum ,
Component (B): potassium nitrate,
Component (C): glycerin, and component (D): sorbitol,
The content of the component (C) is 25 % by mass to 45% by mass, the content of the component (D) is 20 % by mass to 32% by mass with respect to the total mass of the dentifrice composition, and the content of the component (D) The dentifrice composition whose content ratio of a component (C) is 1-2 . The content of the component (A) is 0.01% by mass to 0.5% by mass with respect to the total amount of the dentifrice composition, and the content of the component (B) is 1% by mass to 10% by mass. The dentifrice composition of Claim 1 satisfy | filling at least any one of these.   The dentifrice composition of Claim 1 or 2 whose moisture content with respect to the whole quantity of a dentifrice composition is 15 mass%-40 mass%.   The dentifrice composition of any one of Claims 1-3 whose pH in 25 degreeC is 4-6.5.   The dentifrice composition of any one of Claims 1-4 which is a toothpaste.