JPS62181212A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:A composition for oral cavity, containing a specific monoterpene, e.g. diosphenol, etc., and having improved effect on removal or nicotine of tobacco. CONSTITUTION:A composition for oral cavity obtained by using (A) one or more monoterpenes selected from diosphenol, phellandral, albomenthone, thymoquinone, chrysanthenone, cryptone, thujone, fenchone, picrocrocin, santenone, alpha-ionone, beta-ionone, alpha-irone, gamma-thujaplicin, artemisia ketone and citral in an amount of preferably 0.01-10wt% based on the total composition together with (B) one or more polishing agents selected from calcium hy drogenphosphate.dihydrate or nonhydrate, neutralized aluminum hydroxide and silicon dioxide. When prepared as a dentifrice, chemical removing action of the component (A) on nicotine and physical removing action of the component (B) on nicotine synergize to provide the aimed composition for the oral cavity capable of exhibiting remarkable removing action on nicotine.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition particularly effective in removing tobacco tar.

In general, oral compositions such as toothpaste and profilakis paste contain stains as a tooth cleaning base.

Abrasives are blended to efficiently remove plaque, food particles, and other substances that adhere to or settle on teeth through physical action, but in order to effectively remove these stains, the abrasive power of the abrasive must be High is desirable. In particular, tobacco tar is strongly stuck to the teeth of smokers, and it is necessary to use a highly abrasive abrasive to remove such cigarette tar.

However, the higher the abrasive power of the abrasive, the more easily the tooth surface is scraped and damaged, and there is a risk of tooth wear. Conversely, if the polishing power is lowered in order to avoid damage to the teeth, there is a problem in that the cleaning power also decreases. In addition, cigarette tar that has adhered or settled on the teeth can be removed to some extent by brushing the tooth surface with a toothbrush, but areas that the toothbrush cannot reach cannot be cleaned, and therefore, physical effects such as brushing with abrasives cannot be used. It is desired to clean the teeth without relying on the teeth, and for this reason, active ingredients that remove the adhesion and deposits of cigarette tar from the teeth through chemical action have been proposed, but active ingredients with even higher tar removal effects have been proposed. is desired.

The present invention was made in response to the above-mentioned needs, and an object of the present invention is to provide an oral composition that is effective in removing tar from cigarettes.

The inventors of the present invention conducted intensive studies to achieve the above objectives, and found that diosphenol, ferlandral, carbomentone, thymoquinone, chrysantenone, krypton,
Thujone, fenchone, picrocrocin, santenone, alpha
It has been found that monoterpenes selected from -ionone, β-ionone, α-ionone, hinokitiol, α-huyapurin, γ-thujapurin, artemisia ketone, and citral specifically exhibit a tobacco tar removal effect.

That is, as shown in the experimental examples described later, even though they are the same monoterpenes, pinene, cineole, terpineol, limonene, etc. have almost no ability to remove tobacco tar, but the above-mentioned diosphenols, ferlandral, carbomentone, thymoquinone, chrysantenone,
krypton.

Thujone, fencon, pikurokuchishin, sante, non,
α-ionone, β-ionone, α-ionone.

Hinokitiol, α-thujapurin, γ-thujapurin, artemisia ketone, and citral are highly effective in removing tobacco tar, and therefore, these monoterpenes have specific effects as active tar-removing ingredients incorporated into oral compositions. I discovered that. In addition, when these monoterpenes are combined with an abrasive, especially calcium hydrogen phosphate dihydrate, calcium hydrogen phosphate anhydrate, neutralized aluminum hydroxide, and silicon dioxide, and prepared as a toothpaste, It was discovered that the chemical stain removal effect of the monoterpene and the physical stain removal effect of the abrasive are synergistic, and a remarkable cigarette tar removal effect can be obtained, leading to the present invention.

The present invention will be explained in more detail below.

The oral composition according to the present invention contains diosphenol as an active ingredient for removing tobacco tar.

ferlandral, carbomentone, thymoquinone.

Chrysantenone, krypton, thujone, fenchone, bicrocrocin, santenone, alpha ionone.

One or more monoterpenes selected from β-ionone, α-iron, hinokitiol, α-thujapurin, γ-thujapurin, artemisia ketone, and citral are blended.

Here, the blending amount of these monoterpenes is preferably 0.01 to 10%, particularly 0.1 to 5% of the total composition. If the amount exceeds 10%, irritation to the oral mucosa may occur.

The oral composition of the present invention can be prepared and applied as a toothpaste, mouthwash, chewing gum, etc. for removing cigarette tar adhering to teeth. By incorporating terpenes, it exhibits a remarkable sludge-removal effect. Therefore, the amount of abrasive during tooth brushing can be reduced, or an abrasive with low abrasive power can be used, resulting in a toothpaste with high cleaning power and significantly reduced abrasiveness to teeth.・High cleaning efficiency can be achieved.

Here, as the polishing agent, calcium hydrogen phosphate dihydrate and anhydrate, calcium carbonate, calcium pyrophosphate, calcium sulfate, insoluble sodium metaphosphate,
Silicon dioxide, aluminosilicate, aluminum hydroxide, aluminum oxide.

Resins, etc., and one or more of these may be used, but polishing agents whose 10% aqueous slurry has a pH of 9 or less, especially calcium hydrogen phosphate dihydrate and anhydrate,
Neutralized aluminum hydroxide (modified aluminum hydroxide whose surface has been treated with phosphoric acid or phosphates, etc.) and silicon dioxide are preferable, and by using this type of abrasive, it will be good even after long-term storage. You can get effective toothpaste. The blending amount of the abrasive is 1 to 50%, especially 5 to 50%.
It is preferable to set it to 40%.

As for the other components of the oral composition of the present invention, appropriate components are selected and used depending on the type of composition.

For example, when used as a toothpaste, in addition to the above-mentioned abrasives, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium alginate, and carragetin are used. Binder such as gum arabic, xanthan gum, polyvinyl alcohol (compounding amount usually 0.3 to 5%), polyethylene glycol.

Thickening agents (10-70%) such as sorbitol, glycerin, propylene glycol, sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, Surfactants (0-5%) such as N-acyl glutamate, lauryl diethanolate, and Shoto fatty acid ester, as well as saccharin sodium, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, perillartine, and p-methoxycinnamine dialdehyde. Sweeteners such as thaumatin, fragrances, preservatives, various active ingredients, etc. may be added.

Effects of the Invention The oral composition of the present invention is highly effective in removing tobacco tar due to the inclusion of the above-mentioned monoterpene.

Next, the effects of the present invention will be specifically explained using experimental examples.

[Experimental Example 1] The cleaning power of the following compositions A to C containing the monoterpenes shown in Table 1 was evaluated by the following method. The results are shown in Table 1.

Composition A Monoterpene 1% Sodium Lauryl Sulfate l Water Balance 100
．． 0% Composition B, CBC Monoterpene 1% 1% Sodium lauryl sulfate 11 Calcium hydrogen phosphate dihydrate 25-Silicon dioxide
-25 polishing solvent
Remaining Remaining 100.0χ100.0χ The polishing solvent is glycerin, propylene glycol,
It is a mixture of sodium carboxymethylcellulose and water.

Cleaning power evaluation method Cigarette tar was collected in the usual manner and spread uniformly onto a 13.5 m square tile. This is about 130-140
After heating and drying at C for a day and night, set it in a polishing container,
A sample (15 mm) was plunged under a load of 200 g, and the removal rate of tobacco tar from the polished tile was visually evaluated.

The number of times of brushing differs depending on the loft of the tar, so the internal standard l-carvone (1% aqueous dispersion of sodium lauryl sulfate, hereinafter referred to as the same number of brushing times that will give a removal rate of about 6) will be used. It was set each time.

l-carvone at 6.0° 3-octatool at 4.5. Using peppermint oil as a standard of 2.0° and water as a standard of 0, the evaluation of the sample was calculated by creating a calibration curve from the experimental values and standard values of these internal standards.

Also, as a brushing brush, there are 44 bristles in 1
The material used was nylon (62) with a hair thickness of 8 mil (approximately 0.211 per bundle) and a hair length of 12 m11, and the hardness of the material was M according to the Household Goods Quality Indication Law.

Evaluation criteria rating 1: Tobacco tar removal rate 0-10% Almost no tar removed 10: 90-100 Completely removed Table 1 * Calcium hydrogen phosphate, 2 No.
Suspended in 75% of the old π-yong.

From the results in Table 1, it is recognized that among the monoterpenes, krypton, diosphenol, carbomentone, suntenone, citral, and thujone have a specific oxidation-removal effect. In addition, it has been found that when these monoterpenes are used together with abrasives (calcium hydrogen phosphate dihydrate, silicon dioxide), these act synergistically and exhibit a remarkable slag removal effect. .

In addition, it was confirmed that ferlandral, thymoquinone, chrysantenone, fenchone, picrocrocin, α-ionone, β-ionone, α-iron, hinokitiol, α-thujapurine, γ-thujapurine, and artemisia ketone also have excellent tar removal effects. did.

[Experimental Example 2] Toothpastes having the formulations shown in Table 2 were prepared, and their stain removal and inhibition effects were investigated by the methods shown below.

Eight healthy people (male, smokers) were selected and tested using the toothpaste shown in Table 2 (Nal, 2: Invention toothpaste, patient 3: Comparison toothpaste) for one month each. .

Scaling was performed two weeks before the start of each test,
The subjects were only allowed to brush until the start of the test.

The amount of tooth brushing was approximately 2/3 of the length of the hair strands, and the subjects were asked to brush their teeth three times a day, with no particular instructions on how to brush their teeth.

Photographs were taken twice, before the start of the test and 4 weeks after the start of the test, and the degree of stain adhesion was evaluated using the following method.

In addition, colloidal silica is used as a filler and thickener in the formulation, and has almost no abrasive power.

Stin's evaluation method: Cover the photograph (enlarged to 3.5 times the actual size) with a transparent plastic film depicting a lattice with an interval of 3.5, and count the squares that have dirt on them. It was set as Stin's rating. The evaluation site was 3-3 maxillary and labial surfaces, a total of 12 teeth.

The results are shown in Table 3.

Table 2 Hayashi: Does not contain monoterpenes.

Table 3 From the results shown in Table 3, it is found that the toothpaste of the present invention containing krypton has excellent stain removal and inhibition effects.

Examples will be shown below, but the present invention is not limited to the following examples.

[Example 1] Toothpaste calcium hydrogen phosphate dihydrate 45.0%85%
Glycerin 10.060% Sorbitol 25.0 Carboxymethyl Cellulose 0.5 Sodium Veegum 0.2 Lagenan 0.3 Sodium Satucharin 0.2 Sodium Lauryl Sulfate 1.2 Vitamin E#: Acid Acid
0.1 Fragrance (contains 50% carbomentone) 1
．． 0 Preservative Trace amount [Example 2] Toothpaste abrasive silicon dioxide 1000% Propylene glycol 2.060% Sorbitol 20.0 Carboxymethylcellulose 2.0 Sodium saccharin 0.1 Sodium lauryl sulfate 1.5 α-Alumina anhydrate 3. 0 colloidal silica
3.0 fragrance (citral 40%,
Contains 30% thujone) 1.0 preservative
Trace amount [Example 3] Toothpaste Aluminum hydroxide 18.0% Propylene glycol 2.085% Glycerin 25.0 Hydroxyethyl cellulose 1.2 Saccharin sodium
0.1 Sodium lauryl sulfate
0.7 Lauroyl diethanolamide 0.8 Colloidal silica 3.0 Sodium monofluorophosphate 0.76 Preservatives
trace water
1 total
100.0% [Example 4] Mouthwash ethanol 5.0% Sodium saccharin 0.05 Sodium monofluorophosphate 0.05 Chlorhexidine gluconate 0.005 Lauryl diethanolamide 0.4 Pigment
Appropriate amount of preservative
[Antioxidant] [Example 5] Lozenge

Claims (1)

[Claims] 1. Diosphenol, phelandral, carbomentone, thymoquinone, chrysantenone, krypton, thujone, fenchone, picrocrocin, santenone, α-ionone, β-ionone, α-ionone, hinokitiol,
An oral composition comprising one or more monoterpenes selected from α-thujapurin, γ-thujapurin, artemisia ketone, and citral. 2. Monoterpene content is 0.01 to 1 in the entire composition
The oral composition according to claim 1, which has a content of 0% by weight. 3. It is prepared as a toothpaste, and its abrasive contains one or more selected from calcium hydrogen phosphate dihydrate, calcium hydrogen phosphate anhydrate, neutralized aluminum hydroxide, and silicon dioxide. The oral composition used according to claim 1 or 2.