JP2003183141A - Toothpaste composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a taurine-containing toothpaste composition which allows no precipitation of taurine crystals at low temperatures, inhibits discoloration upon storage under heating conditions and exerts an excellent shelf stability and usability. <P>SOLUTION: This composition contains 0.5-4 mass% taurine and ≥2 mass% at least one water-soluble, neutral salt selected from sodium chloride, sodium sulfate and potassium nitrate and has a water content of 30-55 mass% and a pH of 5-7. <P>COPYRIGHT: (C)2003,JPO

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition containing taurine, and more particularly, to a use in which both low-temperature storage stability and warm storage stability are improved. The present invention relates to a taurine-containing dentifrice composition having a good feeling. 2. Description of the Related Art It has been known that a compound having an amino group such as taurine is incorporated into an oral composition (Japanese Patent Laid-Open No. 63-132).
820, JP-A-6-247834). However, there is a problem that discoloration occurs in a compound-containing oral composition having an amino group, and it is also known to suppress discoloration by using a specific fragrance (Japanese Patent Laid-Open No. 59-510).
9, JP-A-11-35436, JP-A-11-712
No. 52). [0003] Further, in the taurine-containing dentifrice composition, there is a problem that crystals of taurine are precipitated at a low temperature, which impairs the appearance and the feeling of use. And the pH is 7.5 to 10
Thus, a method for suppressing crystal precipitation was proposed (Japanese Patent Application No. 2001-46026). However, in the prior art, it has not been possible to suppress both the crystal precipitation of the taurine-containing dentifrice composition at a low temperature and the discoloration due to storage under heating. [0005] The present invention has been made in view of the above circumstances,
An object of the present invention is to provide a dentifrice composition having excellent feeling in use, in which taurine crystals do not precipitate at a low temperature and discoloration due to storage under heating is suppressed. Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to achieve the above object, and as a result, have found that taurine is 0.5 to 4% (mass percentage, hereinafter the same). In a dentifrice composition having a pH of 5 to 7 and a water content of 30 to 55%, one or more of water-soluble neutral salts selected from sodium chloride, sodium sulfate, and potassium nitrate are unexpectedly added. It has been found that by containing 2% or more, a dentifrice composition excellent in feeling in use can be obtained in which taurine crystals do not precipitate at a low temperature and discoloration due to storage under heating is suppressed, and the present invention is achieved. It has been reached. Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention contains taurine. In this case, the amount of taurine to be added to the dentifrice composition of the present invention is in the range of 0.5 to 4%, particularly preferably 2 to 4% of the whole composition. If the amount is less than 0.5%, sufficient pharmacological effect of taurine cannot be obtained, and if it exceeds 4%, the low-temperature storage stability is inferior and the object of the present invention cannot be achieved. [0008] The dentifrice composition of the present invention further contains at least 2%, particularly at least 2.5%, of one or more water-soluble neutral salts selected from sodium chloride, sodium sulfate and potassium nitrate. If the amount is less than 2%, the effect of adding the water-soluble neutral salt is low, and the low-temperature storage stability is poor. The upper limit of the amount of these water-soluble neutral salts is not particularly limited, but is preferably 20% or less, particularly preferably 15% or less, from the viewpoint of usability. [0009] In the dentifrice composition of the present invention, the water content of the whole composition is 30 to 55%, particularly 30 to 50%. If the amount is more than 55%, the feeling of use will be watery and worse, and if it is less than 30%, the low-temperature storage stability will be poor, and the object of the present invention will not be achieved. [0010] The dentifrice composition of the present invention has a pH of 5 to 7, especially 5.5 to 7. If the pH is less than 5, safety issues such as demineralization of teeth and irritation of oral mucosa occur, and if it exceeds 7, the storage stability under heating is poor, and the object of the present invention cannot be achieved. The dentifrice composition of the present invention contains an abrasive. In this case, the compounding amount is 40% or less, especially 3%.
It is preferable that the content be 5% or less. If the amount exceeds 40%, the low-temperature storage stability is poor, and the object of the present invention may not be achieved in some cases. Examples of the polishing agent include calcium hydrogen phosphate dihydrate, calcium hydrogen phosphate anhydrous, calcium pyrophosphate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, sedimentable amorphous silica, and aluminosilicate. , Zirconosilicate, aluminum oxide, aluminum hydroxide, microcrystalline cellulose, resin,
One or more base materials such as tribasic magnesium phosphate and zeolite can be used in combination. Preferably, silicic acid or silicates such as silicic anhydride, precipitated silica, aluminosilicate, and zirconosilicate are used. The composition of the present invention may further contain ordinary dentifrices such as thickeners, binders, surfactants, sweeteners, preservatives, active ingredients, pigments, fragrances and the like in addition to the above-mentioned components. Ingredients used in the blending within the range that does not impair the effects of the present invention,
Can be manufactured. [0013] For example, in addition to the above-mentioned components, solvit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, erythritol One or more of these can be blended. The compounding amount is usually 10 to 60% of the whole composition, especially 15
６０60%. Examples of the binder include sodium carboxymethylcellulose, hydroxyethylcellulose, carrageenan, xanthan gum, tragacanth gum, karaya gum, gum arabic, polyvinyl alcohol, polyacrylate, carboxyvinyl polymer and / or a salt thereof.
Examples include polyvinylpyrrolidone, guar gum, gelatin, Avicel, montmorillonite, kaolin, bentonite and the like. The compounding amount is usually 0.1 to 4 of the whole composition.
%, More preferably 0.2 to 3%. The surfactant includes an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like. Specifically, sodium lauryl sulfate, sodium N-lauroyl taurine, N-acyl sarcosinate, sodium α-olefin sulfonate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-
N-hydroxyethyl imidazolinium betaine, N-
Acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic, decaglyceryl laurate and the like. These surfactants may be used alone or in combination of two or more, and the compounding amount is usually 0.01 to 5%, more preferably 0.05 to 4% of the whole composition. Various active ingredients include fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride and sodium monofluorophosphate, and water-soluble compounds such as potassium and sodium orthophosphates. Phosphoric acid compounds, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, isopropylmethylphenol, chlorhexidine salts, triclosan , Biosol, cetylpyridinium chloride, benzethonium chloride, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate Chelating phosphoric acid compounds, copper compounds such as copper gluconate, strontium chloride, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, epidihydrocholesterine dihydrocholesterol, trichlorocarbanilide, zinc citrate, touki soft Extracts, extracts of oak, chamomile, clove, rosemary, ogre, safflower and the like. As the fragrance, JP-A-11-354 is used.
No. 36, it is preferable to blend a compatible aldehyde-based flavor, and further, other flavors such as menthol, carvone, anethole, cineol, methyl salicylate,
Cinamic aldehyde, eugenol, 3,1-menthoxypropane-1,2-diol, thymol, linalool, linalool acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthan-3-carboxamide, pinene, octyl aldehyde, Citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate,
Ethylmethylethynylglycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazone, ethyl lactate, ethylthioacetate, etc. , Peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, Lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil Mixtures of natural flavors such as iris concrete, absolute peppermint, absolute rose and orange flower, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. One or more kinds of fragrances and the like can be blended. As a sweetener, saccharin sodium,
Preservatives such as aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perillartin; preservatives such as paraoxybenzoic acid esters such as butyl paraben and ethyl paraben; sodium benzoate; and a coloring agent blue. No. 1, yellow No. 4, green No. 3, titanium dioxide and the like. The amounts of these components may be any ordinary amounts within a range that does not impair the effects of the present invention. The composition of the present invention can be used as a container, in addition to tubes such as an aluminum laminated tube, an EVAL tube, a glass-deposited plastic tube, and a resin-baked aluminum tube, a dispenser container and a squeeze container by mechanical or differential pressure, and a laminated film. Containers and bottles can also be filled. A laminated film usually has two or more layers, and is made of a synthetic resin such as polyethylene, polyethylene terephthalate, polyester, biaxially-stretched polypropylene, unstretched polypropylene, polyacrylonitrile, ethylene-vinyl acetate copolymer, aluminum, or gold. , Metal foil such as silver, paper, and the like. In consideration of strength, flexibility, weather resistance and the like, generally, about 2 to 5 layers are used. The material of the bottle is not particularly limited, but synthetic resins such as polyethylene, polyethylene terephthalate, polyester, and polypropylene, and glass can be suitably used. The method for producing the bottle is not limited to injection molding, hollow molding, pressing, vacuum molding, or the like, or a so-called in-line filling method for simultaneously molding and filling a container. The taurine-containing dentifrice composition of the present invention does not precipitate taurine crystals at a low temperature, suppresses discoloration due to storage under heating, and has excellent storage stability and usability. is there. EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition,% in each example is all mass%. Examples 1 to 5 and Comparative Examples 1 to 5 Stability test of dentifrice (1) A dentifrice was prepared by adding the components shown in Table 1 to the following common composition, and the dentifrice was prepared at 60 ° C. for one month. After storage at −5 ° C. and −10 ° C. for one month, the product stored at 60 ° C. changes color to −5 ° C.
The samples stored at -10 ° C and at -10 ° C were evaluated for the presence of crystals.
In addition, the usability was evaluated for each. The evaluation criteria are shown below. Common composition for dentifrice Taurine Amount (%) shown in Table 1 Citric acid 0.15 Sodium carboxymethylcellulose 1.6 Propylene glycol 3.0 Sodium lauryl sulfate 1.8 Water-soluble neutral salt Amount shown in Table 1 Saccharin sodium 0 .15 Methyl paraben 0.1 Butyl paraben 0.01 Silicic anhydride 20.0 Fragrance 1.0 Purified water 70% sorbite solution shown in Table 1 Total balance (amount shown in Table 1) 100.0% 1) [Examples 6 to 8, Comparative Examples 6 and 7] Stability test of dentifrice (2) In the same manner as in dentifrice stability test (1), the components shown in Table 2 in the following common compositions Was prepared and evaluated. Common dentifrice composition taurine Amount (%) shown in Table 2 Citric acid 0.05 Sodium carboxymethyl cellulose 2.2 Propylene glycol 3.0 Sodium lauryl sulfate 1.8 Sodium sulfate Amount shown in Table 2 Saccharin sodium 0.15 Methyl paraben 0.1 Butylparaben 0.01 Silicic anhydride 9.0 Fragrance 1.0 Purified water 70% sorbite liquid as shown in Table 2 Total balance (amount as shown in Table 2) 100.0% As shown in Tables 1 and 2, the dentifrice composition containing taurine has a water content of 30 to 55%, a pH of 7 or less, and a water-soluble neutral salt selected from sodium chloride, sodium sulfate and potassium nitrate. By adding 2% or more,
It can be seen that discoloration during warm storage is suppressed, and no taurine crystals are precipitated even after low-temperature storage, and a dentifrice composition excellent in use feeling can be obtained. [Example 9, Comparative Examples 8, 9] Stability test of dentifrice (3) In the same manner as stability test of dentifrice (1), the components shown in Table 3 were added to the following common composition. A prepared dentifrice was prepared and evaluated. Common dentifrice composition taurine Amount shown in Table 3 (%) Sodium hydroxide Amount shown in Table 3 Sodium carboxymethylcellulose 1.4 Propylene glycol 3.0 Sodium lauryl sulfate 1.8 Sodium sulfate Amount shown in Table 3 Saccharin sodium 0.15 Methyl paraben 0.1 butyl paraben 0.01 silicic anhydride 25.0 fragrance 1.0 purified water 70% sorbite solution described in Table 3 Total of balance (amount described in Table 3) 100.0% [Table 3] As shown in Table 3, the dentifrice composition containing taurine had a water content of 30 to 55% and a pH of 7 or less.
By adding 2% or more of sodium sulfate, a water-soluble neutral salt, discoloration during warm storage is suppressed, and taurine crystals do not precipitate even after low-temperature storage, so that a dentifrice composition excellent in feeling in use can be obtained. It was confirmed. [Examples 10, 11 and Comparative Examples 10, 11] Stability test of dentifrice (4) In the same manner as in dentifrice stability test (1), the components shown in Table 4 were used in the following common compositions. Was prepared and evaluated. Dentifrice common composition taurine Amount (%) shown in Table 4 Citric acid 0.30 Sodium carboxymethylcellulose 1.0 Propylene glycol 3.0 Sodium lauryl sulfate 1.8 Sodium sulfate Amount shown in Table 4 Saccharin sodium 0.15 Methyl paraben 0.1 Butylparaben 0.01 Abrasive (type shown in Table 4) Perfume shown in Table 4 1.0 Purified water 70% sorbite solution shown in Table 4 Total balance (amount shown in Table 4) 100.0% [Table 4] As shown in Table 4, the dentifrice composition containing taurine had a water content of 30 to 55% and a pH of 7 or less.
By adding 2% or more of sodium sulfate, a water-soluble neutral salt, discoloration during warm storage is suppressed, and taurine crystals do not precipitate even after low-temperature storage, so that a dentifrice composition excellent in feeling in use can be obtained. It was confirmed. Examples are shown below. In any of the compositions, there is almost no discoloration after storage at 60 ° C. for one month, and no precipitation of crystals after storage at -5 ° C. and -10 ° C. for one month. The feeling of use was also good. Example 12 Toothpaste Taurine 2.5% Citric acid 0.15 Sodium carboxymethylcellulose 1.6 Propylene glycol 3.0 70% Sorbite solution 20.25 Sodium lauryl sulfate 1.8 Potassium nitrate 5.0 Saccharin sodium 0 .15 methyl paraben 0.1 butyl paraben 0.01 silicic anhydride 25.0 titanium oxide 0.5 fragrance 1.0 purified water 38.94 total 100.0% (moisture content 45%, pH 5.9) Example 13 Toothpaste Taurine 2.5% Tranexamic acid 0.1 Triclosan 0.1 Citric acid 0.15 Sodium carboxymethylcellulose 1.1 Sodium polyacrylate 0.5 Propylene glycol 3.0 70% sorbit solution 37.84 sodium lauryl sulfate Arm 1.8 Sodium 2.5 Sodium saccharin 0.15 Methylparaben 0.1 Butylparaben 0.01 20.0 Titanium oxide 0.5 Perfume 1.0 Purified water 28.65 Total 100.0% silicic anhydride sulfate (in the composition [Example 14] toothpaste taurine 2.5% sodium monofluorophosphate 0.75 glycyrrhetinic acid 0.1 citric acid 0.15 xanthan gum 0.8 sodium alginate 0 0.8 Propylene glycol 3.0 70% sorbite liquid 33.34 Sodium lauryl sulfate 1.8 Sodium sulfate 2.5 Saccharin sodium 0.15 Methyl paraben 0.1 Butyl paraben 0.01 Silicic anhydride 20.0 Titanium oxide 0.5 Fragrance 1.0 Purified water 30.00 Total 100.0% (Group [Example 15] Toothpaste Taurine 2.5% Dipotassium glycyrrhizinate 0.1 Tocopherol acetate 0.1 Citric acid 0.15 Xanthan gum 0.8 Sodium alginate 0 .8 Propylene glycol 3.0 70% sorbite solution 35.00 Sodium lauryl sulfate 1.8 Sodium chloride 5.0 Saccharin sodium 0.15 Methyl paraben 0.1 Butyl paraben 0.01 Silicic anhydride 20.0 Titanium oxide 0.5 Fragrance 1.0 Purified water 29.49 Total 100.0% (Moisture content 40%, pH 6.4) Example 16 Toothpaste Taurine 3.5% Citric acid 0.15 Xanthan gum 0.8 Sodium alginate 0.8 Propylene glycol 3.0 70% sorbit 32.82 Xylitol 5.0 Sodium lauroyl sarcosine 0.3 Sodium lauryl sulfate 1.8 Sodium chloride 10.0 Saccharin sodium 0.15 Methyl paraben 0.1 Butyl paraben 0.01 Silicic anhydride 15.0 Titanium oxide 0.5 Fragrance 1 2.0 purified water 25.17 total 100.0% (moisture content 35%, pH 5.9)

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Claims (1)

Claims: 1. Containing 0.5 to 4% by mass of taurine and 2% by mass or more of one or more water-soluble neutral salts selected from sodium chloride, sodium sulfate and potassium nitrate. ,
A dentifrice composition characterized in that the composition has a water content of 30 to 55% by mass and a pH of 5 to 7.