CN108113943A - A kind of Pediatric Oral Emergency care method - Google Patents
A kind of Pediatric Oral Emergency care method Download PDFInfo
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Abstract
The invention discloses a kind of Pediatric Oral Emergency care method, including at least once daily using Pediatric Oral Emergency conditioning liquid containing gargling 5 15 minutes, being used continuously more than surrounding or surrounding.The oral care method of the present invention can clean oral cavity and tooth, to toothache, bleeding gums, canker sore, gingivitis, periodontitis, abscess of throat, the common orals such as oral peculiar smell problem has good mitigation, it can maintain normal oral microorganism flora, ensure oral health, it is finally reached and dispels oral peculiar smell, pre- anti-caries, promote tooth calcification, firm tooth, the effect of nutrition gum and healthy periodontal, the Pediatric Oral Emergency care method of the present invention can effectively take good care of protection Pediatric Oral Emergency health, both oral cavity was suitble to not use in due course, it is also suitable for common oral care.
Description
Technical field
The present invention relates to a kind of oral health method, more particularly to a kind of Pediatric Oral Emergency care method.
Background technology
Oral cavity, throat are the passage of feed and breathing, and are the only way which must be passed that diet water enters human body, raw with the health of people
It deposits closely bound up.So health generates human body important influence, bacterium and virus infection, air pollution, with sound excessively,
The factors such as pungent scorching stimulation food easily lead to oral problem, if mistake is controlled, misdiagnosis, mistake are controlled, easily evolve into periodontitis etc..
In daily life, people are accustomed to cleaning tooth and oral cavity with toothpaste, but always have some specific crowds or specific field
Close, do not have condition for various reasons or cannot be brushed teeth with toothpaste, as with after the meal, see client before, before and after tooth treatment.Particularly with
The children that will not be brushed teeth maintain oral health just to seem extremely important by effective oral care method.
It not only includes the congenital development situation in oral cavity to the oral health of children, closely related with whole body health situation, and
And further including posteriori factor, i.e., good eating habit, good oral sanitary habit, periodic oral inspection prevent oral cavity
Unexpected injury etc..At present, Pediatric Oral Emergency care method is mainly contained by using some mouthwashes, oral nursing liquid etc. and gargled
Chamber reaches cleaning, eliminates oral peculiar smell effect, also has some oral nursing liquids to play an important role of to eliminate dental plaque and kill mouth
The effect of intracavitary bacterium.But the qualities such as oral nursing liquid, mouthwash sold currently on the market are irregular.Research is a kind of new
Pediatric Oral Emergency care method, the new oral nursing liquid of exploitation just seem very necessary.
The content of the invention
The present invention provides a kind of Pediatric Oral Emergency care methods.The present invention adopts the following technical scheme that：
A kind of Pediatric Oral Emergency care method：At least once daily using Pediatric Oral Emergency conditioning liquid containing gargling 5-15 minutes, continuously
More than surrounding or surrounding.
A kind of Pediatric Oral Emergency care method：At least once daily, contained every time using 15-30mL Pediatric Oral Emergencies conditioning liquid and gargle 5-
It 15 minutes, is used continuously more than surrounding or surrounding, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：Plant extract
0.5-5 parts of object, 0.3-0.9 parts of xylitol, 0.05-0.5 parts of vitamin C, 0.05-0.2 parts of ethyl alcohol, lauroyl arginine ethyl ester salt
0.001-0.003 parts of hydrochlorate, 0.005-0.02 parts of microcrystalline cellulose, 0.001-0.01 parts of Glucosamine, allantoin 0.001-
0.01 part, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
A kind of Pediatric Oral Emergency care method：At least once daily, contained every time using 15-30mL Pediatric Oral Emergencies conditioning liquid and gargle 5-
It 15 minutes, is used continuously more than surrounding or surrounding, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：Plant extract
0.5-5 parts of object, 0.01-0.1 parts of Sipunculidae preparation on mice, 0.3-0.9 parts of xylitol, 0.05-0.5 parts of vitamin C, ethyl alcohol
0.05-0.2 parts, 0.001-0.003 parts of lauroyl arginine ethyl ester hydrochloride, 0.005-0.02 parts of microcrystalline cellulose, amino Portugal
0.001-0.01 parts of grape sugar, 0.001-0.01 parts of allantoin, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
The present invention also provides a kind of Pediatric Oral Emergency conditioning liquid, including following components in parts by weight：Plant extracts 0.5-5
Part, 0.3-0.9 parts of xylitol, 0.05-0.5 parts of vitamin C, 0.05-0.2 parts of ethyl alcohol, lauroyl arginine ethyl ester hydrochloride
0.001-0.003 parts, 0.005-0.02 parts of microcrystalline cellulose, 0.001-0.01 parts of Glucosamine, allantoin 0.001-0.01
Part, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
The present invention also provides a kind of Pediatric Oral Emergency conditioning liquid, including following components in parts by weight：Plant extracts 0.5-5
Part, 0.01-0.1 parts of Sipunculidae preparation on mice, 0.3-0.9 parts of xylitol, 0.05-0.5 parts of vitamin C, 0.05-0.2 parts of ethyl alcohol,
0.001-0.003 parts of lauroyl arginine ethyl ester hydrochloride, 0.005-0.02 parts of microcrystalline cellulose, Glucosamine 0.001-
0.01 part, 0.001-0.01 parts of allantoin, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
Preferably, the preparation method of heretofore described plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, point ground
Plum, Chinese violet smash it through 20-50 mesh sieves respectively, take Radix Ophiopogonis 6-15g, cassia bark 2-10g, Herba Andrographitis 1-5g, point after sieving
Ground plum 1-5g, Chinese violet 0.5-2.5g are added to 30-90g mass fractions and are 65-85%, are pre-heated to 30-40 DEG C of ethyl alcohol
In aqueous solution, ultrasonic extraction 20-60 minutes under the conditions of power is 200-300W, frequency is 40-50KHz, with 5000-8000
Rev/min rotating speed centrifuge 25-45 minute, take centrifugation after supernatant liquid, cross 100-500 mesh sieves, reservation filtrate, filtrate is steamed
Hair is concentrated into 50 DEG C and measures the medicinal extract that relative density is 1.31-1.33, by medicinal extract under the conditions of 55-65 DEG C, 0.04-0.06MPa
It is dry, obtain the plant extracts that dry basis moisture content is 0.8-1.2%.
It is further preferred that the preparation method of the plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata,
Chinese violet smashes it through 20 mesh sieves respectively, takes the Radix Ophiopogonis 9-9.5g after sieving, cassia bark 6-6.5g, Herba Andrographitis 2-2.3g, point ground
Plum 3-3.5g, Chinese violet 1-1.2g are added to 85-90g mass fractions and are 80-85%, are pre-heated to 35-38 DEG C of ethanol water
In solution, ultrasonic extraction 30-40 minutes under the conditions of power is 200W, frequency is 40KHz, with 7000-8000 revs/min turn
Speed centrifugation 30-35 minutes, takes the supernatant liquid after centrifugation, crosses 300 mesh sieves, retains filtrate, and filtrate is concentrated by evaporation to 50 DEG C of surveys
Determine the medicinal extract that relative density is 1.31-1.33, medicinal extract is dry under the conditions of 55-60 DEG C, 0.04-0.06MPa, it obtains butt and contains
Water is the plant extracts of 0.8-1.0%.
Most preferably, the preparation method of the plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, pale reddish brown
Chinese violet smashes it through 20 mesh sieves respectively, takes Radix Ophiopogonis 9g, cassia bark 6g, Herba Andrographitis 2g, Androsace umbellata 3g, Chinese violet 1g after sieving,
Be added to 90g mass fractions for 85%, be pre-heated in 35 DEG C of ethanol water, power be 200W, frequency is 40KHz items
Ultrasonic extraction 30 minutes under part are centrifuged 30 minutes with 8000 revs/min of rotating speed, take the supernatant liquid after centrifugation, cross 300 mesh
Sieve retains filtrate, and filtrate is concentrated by evaporation to 50 DEG C and measures the medicinal extract that relative density is 1.31, by medicinal extract in 55 DEG C, 0.04MPa
Under the conditions of it is dry, obtain the plant extracts that dry basis moisture content is 0.8%.
Preferably, the preparation method of heretofore described Sipunculidae preparation on mice is：By the sodium-chloride water solution of 4mol/L,
The EDTA aqueous solutions of 6mmol/L, the Na of 0.2mol/L2HPO3The NaH of aqueous solution and 0.2mol/L2PO3Aqueous solution is according to volume ratio
For (80-100):(80-100):(3-7):(4-8) is uniformly mixed, and obtains extractant, ocean siphon-worm is cleaned, drain surface water
Point, it is 200- in power in being pre-heated in 35-40 DEG C of 1000-1200g extractants to take the siphon-worm homogenate of 250-260g oceans
Ultrasonic extraction 45-60 minutes, is then centrifuged with 8000-10000 revs/min of rotating speed under the conditions of 250W, frequency are 40-50KHz
30-45 minutes, the supernatant liquid after centrifugation is taken, 300-500 mesh sieves is crossed, first-time filtrate and a filter residue is obtained, to first-time filtrate
Middle addition 300-320g ethyl alcohol when temperature is small for 3-4 DEG C of preservation 3-3.5, crosses 300-500 mesh sieves, obtains secondary filtrate and two
Secondary filter residue adds in 200-230g ethyl alcohol into secondary filtrate, when 2-3 DEG C of preservation 3-3.5 is small, crosses 300-500 mesh sieves, obtains three
Secondary filtrate and three times filter residue add in 100-110g ethyl alcohol into filtrate three times, when 4-5 DEG C of preservation 2-2.5 is small, cross 300-500
Mesh sieve obtains four filtrates and four filter residues, merges secondary filter residue, three times filter residue and four filter residues, freeze-dried, is done
Base water content is the Sipunculidae preparation on mice of 2.5-3%.
Preferably, the preparation method of the Sipunculidae preparation on mice is：By the sodium-chloride water solution of 4mol/L, 6mmol/L
EDTA aqueous solutions, the Na of 0.2mol/L2HPO3The NaH of aqueous solution and 0.2mol/L2PO3Aqueous solution is 100 according to volume ratio:
100:3:8 are uniformly mixed, and obtain extractant, ocean siphon-worm is cleaned, drains surface moisture, take the siphon-worm homogenate of 250g oceans in
Be preheated in 35 DEG C of 1000g extractants, the ultrasonic extraction 45 minutes under the conditions of power is 200W, frequency is 40KHz, then with
10000 revs/min of rotating speed centrifuges 45 minutes, takes the supernatant liquid after centrifugation, crosses 300 mesh sieves, obtains first-time filtrate and once
Filter residue adds in 300g ethyl alcohol into first-time filtrate, when temperature is small for 4 DEG C of preservations 3, crosses 300 mesh sieves, obtains secondary filtrate and two
Secondary filter residue adds in 200g ethyl alcohol into secondary filtrate, when 3 DEG C of preservations 3 are small, cross 300 mesh sieves, obtains filtrate three times and filter three times
Slag adds in 100g ethyl alcohol into filtrate three times, when 5 DEG C of preservations 2 are small, cross 300 mesh sieves, obtains four filtrates and four filter residues,
Merge secondary filter residue, three times filter residue and four filter residues, it is freeze-dried, it obtains the ocean siphon-worm that dry basis moisture content is 2.5% and carries
Take object.
Preferably, the conditional parameter of the freeze-drying is：Pre-freezing temperature is set as -40~-35 DEG C, sublimation temperature setting
For 3-5 DEG C, resolution temperature is set as 25-35 DEG C, vacuum degree 10-15Pa.
Preferably, the solubilizer is the mixture of Glycerin, mixed triester with caprylic acid capric acid and gum arabic, the Glycerin, mixed triester with caprylic acid capric acid
Mass ratio with gum arabic is (3-5)：(1-2).
It is further preferred that the solubilizer is Glycerin, mixed triester with caprylic acid capric acid and the mixture of gum arabic, pungent capric acid glycerine
The mass ratio of ester and gum arabic is 3：2.
The present invention also provides the preparation methods of Pediatric Oral Emergency conditioning liquid：Each raw material is weighed by weight, is uniformly mixed.
The present invention also provides application of the Pediatric Oral Emergency conditioning liquid in Pediatric Oral Emergency nursing.
The present invention oral care method can clean oral cavity and tooth, to toothache, bleeding gums, canker sore, gingivitis,
The common orals such as periodontitis, abscess of throat, oral peculiar smell problem has good mitigation, can maintain the micro- life in normal oral cavity
Object flora ensures oral health, is finally reached and dispels oral peculiar smell, pre- anti-caries, promotes tooth calcification, firm tooth, nutrition
The effect of gum and healthy periodontal, Pediatric Oral Emergency care method of the invention can effectively take good care of protection Pediatric Oral Emergency health, both fit
The chamber that heals up does not use in due course, is also suitable for common oral care.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can be each preferably to get the present invention in any combination
Embodiment.
Specific embodiment
It is further illustrated the present invention below by the mode of embodiment, but does not therefore limit the present invention to the reality
It applies among a scope.The experimental method of actual conditions is not specified in the following example, according to conventional methods and conditions or according to business
Product specification selects.
In following embodiments, primary raw material and instrument used are as follows：
Herba Andrographitis, the ground of acanthaceous plant Herba Andrographitis Andrographis paniculata (Burm.f.) Nees. are done
Dry complete stool.There is clearing heat and detoxicating, cool blood, detumescence.
Androsace umbellata, the drying using Ofthe Primulaceae Androsace umbellata Androsace umbellata (Lour.) Merr. are complete
Grass.With clearing heat and detoxicating, the effect of swelling and pain relieving.For tonsillitis, sphagitis, wind-fire red eye, injury from falling down and throat
The diseases such as swelling and pain.
Chinese violet uses the drying herb of Violaceae Chinese violet Viola yedoensis Makino.Heat-clearing
Removing toxic substances, cool detumescence.Belong to the heat-clearing and detoxifying drug of antipyretic subordinate classification.
Radix Ophiopogonis, liliaceous plant Radix Ophiopogonis (Classification system：Ophiopogonjaponicus (Thunb.) ker-Gawl.)
Dried root plays the role of protecting cardiovascular system, enhances resist oxygen lack, extends the time-to-live of normobaric hypoxia, enhances immune work(
Can, it is hypoglycemic, it slows down aging.
Cassia bark is the dry bark of canella cinnamomum japonicum CinnamomumjaponicumSieb., has warming spleen and stomach for dispelling cold,
The effect of regulating qi-flowing for relieving pain.
Glycerin, mixed triester with caprylic acid capric acid, No. CAS：65381-09-1.
Ocean siphon-worm, is called extra large ginseng, and scientific name Sipunculus nudus, also known as Sipunculus nudus are commonly called as " sandworm ".Not only taste is fresh
U.S. and a kind of low sugar, low fat, high protein, the high-grade nutrient health care food rich in several mineral materials such as zinc, iron, calcium, phosphorus, iodine
Product.In addition to as eating, ocean siphon-worm is considered as " extra large medicine " since ancient times, and the traditional Chinese medical science thinks that ocean siphon-worm nature and flavor are sweet, salty, cold, has
The effect of clearing lung-heat qi-restoratives, nourishing yin and lessening fire.
Lauroyl arginine ethyl ester hydrochloride, No. CAS：60372-77-2.
Xylitol, No. CAS：87-99-0.
Vitamin C, No. CAS：50-81-7.
Ethyl alcohol, No. CAS：64-17-5, purity 99.5%.
Microcrystalline cellulose, No. CAS：9004-36-8, degree of polymerization 3000-10000.
Glucosamine, No. CAS：3416-24-8.
Allantoin, No. CAS：97-59-6.
1,2-PD, No. CAS：57-55-6.
Gum arabic, No. CAS：9000-01-5, food-grade.
It is further illustrated the present invention below by the mode of embodiment, unless otherwise specified, used number is attached most importance to
Measure number.
Embodiment 1
A kind of Pediatric Oral Emergency care method：Contained every time using 20mL Pediatric Oral Emergencies conditioning liquid three times altogether in the morning, afternoon and evening daily and gargle 5
Minute, surrounding is used continuously, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：1.5 parts of plant extracts, xylose
0.6 part of alcohol, 0.25 part of vitamin C, 0.1 part of ethyl alcohol, 0.001 part of lauroyl arginine ethyl ester hydrochloride, microcrystalline cellulose 0.007
Part, 0.004 part of Glucosamine, 0.002 part of allantoin, 0.009 part of solubilizer, 80 parts of water.
The solubilizer is 1,2- propylene glycol.
The preparation method of the plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet difference powder
20 mesh sieves are crossed after broken, Radix Ophiopogonis 15g, cassia bark 10g, Herba Andrographitis 1g, Androsace umbellata 1g, Chinese violet 0.5g after sieving is taken, is added to
90g mass fractions are 85%, are pre-heated in 35 DEG C of ethanol water, are surpassed under the conditions of power is 200W, frequency is 40KHz
Sound extracts 30 minutes, is centrifuged 30 minutes with 8000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, crosses 300 mesh sieves, retains
Filtrate is concentrated by evaporation to 50 DEG C and measures the medicinal extract that relative density is 1.31, by medicinal extract under the conditions of 55 DEG C, 0.04MPa by filtrate
It is dry, obtain the plant extracts that dry basis moisture content is 0.8%.
The preparation method of the Pediatric Oral Emergency conditioning liquid is：Each raw material is weighed by weight, is uniformly mixed.
Embodiment 2
It is substantially the same manner as Example 1, it differs only in, the preparation method of plant extracts is as follows described in the present embodiment 2：It will
Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet smash it through 20 mesh sieves respectively, take the Radix Ophiopogonis 9g after sieving, cassia bark 6g, wear
Heart lotus 2g, Androsace umbellata 3g, Chinese violet 1g are added to 90g mass fractions and are 85%, are pre-heated to 35 DEG C of ethanol water
In, the ultrasonic extraction 30 minutes under the conditions of power is 200W, frequency is 40KHz centrifuges 30 points with 8000 revs/min of rotating speed
Clock, take centrifugation after supernatant liquid, cross 300 mesh sieves, retain filtrate, by filtrate be concentrated by evaporation to 50 DEG C measure relative densities be
1.31 medicinal extract, medicinal extract is dry under the conditions of 55 DEG C, 0.04MPa, obtain the plant extracts that dry basis moisture content is 0.8%.
Embodiment 3
It is substantially the same manner as Example 1, it differs only in, the preparation method of plant extracts is as follows described in the present embodiment 3：It will
Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet smash it through 20 mesh sieves respectively, take the Radix Ophiopogonis 6g after sieving, cassia bark 2g, wear
Heart lotus 5g, Androsace umbellata 5g, Chinese violet 2.5g are added to 90g mass fractions and are 85%, are pre-heated to 35 DEG C of ethanol water
In, the ultrasonic extraction 30 minutes under the conditions of power is 200W, frequency is 40KHz centrifuges 30 points with 8000 revs/min of rotating speed
Clock, take centrifugation after supernatant liquid, cross 300 mesh sieves, retain filtrate, by filtrate be concentrated by evaporation to 50 DEG C measure relative densities be
1.31 medicinal extract, medicinal extract is dry under the conditions of 55 DEG C, 0.04MPa, obtain the plant extracts that dry basis moisture content is 0.8%.
Embodiment 4
A kind of Pediatric Oral Emergency care method：Contained every time using 20mL Pediatric Oral Emergencies conditioning liquid three times altogether in the morning, afternoon and evening daily and gargle 5
Minute, surrounding is used continuously, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：1.5 parts of plant extracts, ocean
0.05 part of siphon-worm extract, 0.6 part of xylitol, 0.25 part of vitamin C, 0.1 part of ethyl alcohol, lauroyl arginine ethyl ester hydrochloride
0.001 part, 0.007 part of microcrystalline cellulose, 0.004 part of Glucosamine, 0.002 part of allantoin, 0.009 part of solubilizer, water 80
Part.
The solubilizer is 1,2- propylene glycol.
The preparation method of the plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet difference powder
20 mesh sieves are crossed after broken, Radix Ophiopogonis 9g, cassia bark 6g, Herba Andrographitis 2g, Androsace umbellata 3g, Chinese violet 1g after sieving is taken, is added to 90g matter
Amount fraction is 85%, is pre-heated in 35 DEG C of ethanol water, and ultrasound carries under the conditions of power is 200W, frequency is 40KHz
It takes 30 minutes, is centrifuged 30 minutes with 8000 revs/min of rotating speed, take the supernatant liquid after centrifugation, cross 300 mesh sieves, retain filtrate,
Filtrate is concentrated by evaporation to 50 DEG C and measures the medicinal extract that relative density is 1.31, medicinal extract is dry under the conditions of 55 DEG C, 0.04MPa,
Obtain the plant extracts that dry basis moisture content is 0.8%.
The preparation method of the Sipunculidae preparation on mice is：By the sodium-chloride water solution of 4mol/L, the EDTA water of 6mmol/L
The Na of solution, 0.2mol/L2HPO3The NaH of aqueous solution and 0.2mol/L2PO3Aqueous solution is 100 according to volume ratio:100:3:8 is mixed
It closes uniform, obtains extractant, ocean siphon-worm is cleaned, drains surface moisture, take the siphon-worm homogenate of 250g oceans in being pre-heated to 35
DEG C 1000g extractants in, the ultrasonic extraction 45 minutes under the conditions of power is 200W, frequency is 40KHz, then with 10000 turns/
The rotating speed of minute centrifuges 45 minutes, takes the supernatant liquid after centrifugation, crosses 300 mesh sieves, obtains first-time filtrate and a filter residue, Xiang Yi
300g ethyl alcohol is added in secondary filtrate, when temperature is small for 4 DEG C of preservations 3,300 mesh sieves is crossed, obtains secondary filtrate and secondary filter residue, to
200g ethyl alcohol is added in secondary filtrate, when 3 DEG C of preservations 3 are small, 300 mesh sieves crossed, filtrate three times and three times filter residue is obtained, to three times
100g ethyl alcohol is added in filtrate, when 5 DEG C of preservations 2 are small, 300 mesh sieves crossed, obtains four filtrates and four filter residues, merge secondary filter
Slag, three times filter residue and four filter residues, it is freeze-dried, obtain the Sipunculidae preparation on mice that dry basis moisture content is 2.5%.It is described cold
Freezing dry conditional parameter is：Pre-freezing temperature is set as -35 DEG C, and sublimation temperature is set as 5 DEG C, and resolution temperature is set as 35 DEG C,
Vacuum degree 15Pa.
The preparation method of the Pediatric Oral Emergency conditioning liquid is：Each raw material is weighed by weight, is uniformly mixed.
Embodiment 5
It is substantially the same manner as Example 4, it differs only in：The preparation method of Sipunculidae preparation on mice described in the present embodiment 5
For：By the sodium-chloride water solution of 4mol/L, the EDTA aqueous solutions of 6mmol/L, 0.2mol/L Na2HPO3Aqueous solution and 0.2mol/
The NaH of L2PO3Aqueous solution is 100 according to volume ratio:80:4:6 are uniformly mixed, and obtain extractant, ocean siphon-worm is cleaned, is drained
Surface moisture takes the homogenate of 250g oceans siphon-worms in being pre-heated in 35 DEG C of 1000g extractants, power be 200W, frequency is
Then ultrasonic extraction 45 minutes under the conditions of 40KHz are centrifuged 45 minutes with 10000 revs/min of rotating speed, take the upper liquid after centrifugation
Body crosses 300 mesh sieves, obtains first-time filtrate and a filter residue, and 300g ethyl alcohol is added in into first-time filtrate, and 3 are preserved for 4 DEG C in temperature
Hour, 300 mesh sieves are crossed, obtain secondary filtrate and secondary filter residue, 200g ethyl alcohol is added in into secondary filtrate, it is small to preserve 3 at 3 DEG C
When, 300 mesh sieves are crossed, obtain filtrate three times and three times filter residue, 100g ethyl alcohol is added in into filtrate three times, when 5 DEG C of preservations 2 are small,
300 mesh sieves are crossed, obtain four filtrates and four filter residues, merge secondary filter residue, three times filter residue and four filter residues, it is freeze-dried,
Obtain the Sipunculidae preparation on mice that dry basis moisture content is 2.5%.The conditional parameter of the freeze-drying is：Pre-freezing temperature is set
For -35 DEG C, sublimation temperature is set as 5 DEG C, and resolution temperature is set as 35 DEG C, vacuum degree 15Pa.
Embodiment 6
It is substantially the same manner as Example 4, it differs only in：The preparation method of Sipunculidae preparation on mice described in the present embodiment 6
For：By the sodium-chloride water solution of 4mol/L, the EDTA aqueous solutions of 6mmol/L, 0.2mol/L Na2HPO3Aqueous solution and 0.2mol/
The NaH of L2PO3Aqueous solution is 80 according to volume ratio:100:7:4 are uniformly mixed, and obtain extractant, ocean siphon-worm is cleaned, is drained
Surface moisture takes the homogenate of 250g oceans siphon-worms in being pre-heated in 35 DEG C of 1000g extractants, power be 200W, frequency is
Then ultrasonic extraction 45 minutes under the conditions of 40KHz are centrifuged 45 minutes with 10000 revs/min of rotating speed, take the upper liquid after centrifugation
Body crosses 300 mesh sieves, obtains first-time filtrate and a filter residue, and 300g ethyl alcohol is added in into first-time filtrate, and 3 are preserved for 4 DEG C in temperature
Hour, 300 mesh sieves are crossed, obtain secondary filtrate and secondary filter residue, 200g ethyl alcohol is added in into secondary filtrate, it is small to preserve 3 at 3 DEG C
When, 300 mesh sieves are crossed, obtain filtrate three times and three times filter residue, 100g ethyl alcohol is added in into filtrate three times, when 5 DEG C of preservations 2 are small,
300 mesh sieves are crossed, obtain four filtrates and four filter residues, merge secondary filter residue, three times filter residue and four filter residues, it is freeze-dried,
Obtain the Sipunculidae preparation on mice that dry basis moisture content is 2.5%.The conditional parameter of the freeze-drying is：Pre-freezing temperature is set
For -35 DEG C, sublimation temperature is set as 5 DEG C, and resolution temperature is set as 35 DEG C, vacuum degree 15Pa.
Embodiment 7
It is substantially the same manner as Example 4, it differs only in, solubilizer described in the present embodiment 7 is Glycerin, mixed triester with caprylic acid capric acid.
Embodiment 8
It is substantially the same manner as Example 4, it differs only in, solubilizer described in the present embodiment 8 is gum arabic.
Embodiment 9
It is substantially the same manner as Example 4, it differs only in, solubilizer described in the present embodiment 9 is Glycerin, mixed triester with caprylic acid capric acid and I
The mass ratio of the mixture of uncle's natural gum, Glycerin, mixed triester with caprylic acid capric acid and gum arabic is 3：2.
Comparative example 1
A kind of Pediatric Oral Emergency care method：Contained every time using 20mL Pediatric Oral Emergencies conditioning liquid three times altogether in the morning, afternoon and evening daily and gargle 5
Minute, surrounding is used continuously, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：0.6 part of xylitol, vitamin
C0.25 parts, 0.1 part of ethyl alcohol, 0.001 part of lauroyl arginine ethyl ester hydrochloride, 0.007 part of microcrystalline cellulose, Glucosamine
0.004 part, 0.002 part of allantoin, 0.009 part of solubilizer, 80 parts of water.
The solubilizer is 1,2- propylene glycol.
The preparation method of the Pediatric Oral Emergency conditioning liquid is：Each raw material is weighed by weight, is uniformly mixed.
Comparative example 2
A kind of Pediatric Oral Emergency care method：Contained every time using 20mL Pediatric Oral Emergencies conditioning liquid three times altogether in the morning, afternoon and evening daily and gargle 5
Minute, surrounding is used continuously, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：1.5 parts of plant extracts, xylose
0.6 part of alcohol, 0.25 part of vitamin C, 0.1 part of ethyl alcohol, 0.001 part of lauroyl arginine ethyl ester hydrochloride, microcrystalline cellulose 0.007
Part, 0.004 part of Glucosamine, 0.002 part of allantoin, 0.009 part of solubilizer, 80 parts of water.
The solubilizer is 1,2- propylene glycol.
The preparation method of the plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet difference powder
20 mesh sieves are crossed after broken, Radix Ophiopogonis 4g, cassia bark 1g, Herba Andrographitis 7g, Androsace umbellata 7g, Chinese violet 0.5g after sieving is taken, is added to 90g
Mass fraction is 85%, is pre-heated in 35 DEG C of ethanol water, ultrasonic under the conditions of power is 200W, frequency is 40KHz
Extraction 30 minutes is centrifuged 30 minutes with 8000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, crosses 300 mesh sieves, retains filter
Filtrate is concentrated by evaporation to 50 DEG C and measures the medicinal extract that relative density is 1.31 by liquid, and medicinal extract is done under the conditions of 55 DEG C, 0.04MPa
It is dry, obtain the plant extracts that dry basis moisture content is 0.8%.
The preparation method of the Pediatric Oral Emergency conditioning liquid is：Each raw material is weighed by weight, is uniformly mixed.
Comparative example 3
A kind of Pediatric Oral Emergency care method：Contained every time using 20mL Pediatric Oral Emergencies conditioning liquid three times altogether in the morning, afternoon and evening daily and gargle 5
Minute, surrounding is used continuously, the Pediatric Oral Emergency conditioning liquid includes following components in parts by weight：1.5 parts of plant extracts, xylose
0.6 part of alcohol, 0.25 part of vitamin C, 0.1 part of ethyl alcohol, 0.001 part of lauroyl arginine ethyl ester hydrochloride, microcrystalline cellulose 0.007
Part, 0.004 part of Glucosamine, 0.002 part of allantoin, 0.009 part of solubilizer, 80 parts of water.
The solubilizer is 1,2- propylene glycol.
The preparation method of the plant extracts is as follows：By Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet difference powder
20 mesh sieves are crossed after broken, Radix Ophiopogonis 20g, cassia bark 15g, Herba Andrographitis 0.5g, Androsace umbellata 0.2g, Chinese violet 0.1g after sieving is taken, adds
Enter to 90g mass fractions for 85%, be pre-heated in 35 DEG C of ethanol water, power be 200W, frequency is 40KHz conditions
Lower ultrasonic extraction 30 minutes is centrifuged 30 minutes with 8000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, crosses 300 mesh sieves,
Retain filtrate, filtrate is concentrated by evaporation to 50 DEG C and measures the medicinal extract that relative density is 1.31, by medicinal extract in 55 DEG C, 0.04MPa items
It is dry under part, obtain the plant extracts that dry basis moisture content is 0.8%.
The preparation method of the Pediatric Oral Emergency conditioning liquid is：Each raw material is weighed by weight, is uniformly mixed.
Measure of merit 1Gum disease remission effect is tested
The age is selected as 120 people of children's gingivitis patient of 8-10 Sui.It is divided into 12 groups, every group of 10 people, respectively using real
Apply a 1-9, the Pediatric Oral Emergency care method of comparative example 1-3 is nursed：Use 20mL children every time three times altogether in the morning, afternoon and evening daily
Surrounding is used continuously containing gargling 5 minutes in oral nursing liquid, observes curative effect.Experimental applications SPSS16.0 statistical softwares, technical data are adopted
Use x2It examines, level of signifiance α=0.05.Gingivitis patient using improvement Loe-Silness index of gingivitis (GI) method come
Assessment：0：Without oulitis；1：Slight oulitis, gum color and luster and quality are slightly changed, but are visited and examined no bleeding；2：Moderate oulitis, gum
Light, redness, hyperplasia, palpation bleeding；3：Severe oulitis, gum apparent redness, hyperplasia have hematostaxis.Each group result it
Between comparison have statistical significance.
Table 1：Gum disease therapeutic effect tests table
Measure of merit 2Fungistatic effect is tested
Test strain：Streptococcus mutans (ATCC 25923), Candida albicans (ATCC 76615).Test method：Respectively
By each actication of culture, with a small amount of thalline of oese picking, it is placed in 10mL sterile waters, through gradient dilution, is made 106-107CFU/
The bacteria suspension of mL, it is spare.Filter paper with card punch is broken into the filter paper of a diameter of 6mm, 10mL is put into after 160 DEG C of hot air sterilization 2h
It impregnates for 24 hours in the Pediatric Oral Emergency conditioning liquid that the present invention uses, is compareed with sterile water.Draw the 100 μ L of bacteria suspension that prepare in
Even spread on corresponding culture dish.It is put into after above-mentioned filter paper is drained surplus liquid with aseptic nipper in culture dish containing bacterium,
Per 2, ware, the culture dish for being inoculated with Candida albicans is put into 37 DEG C of incubators, is incubated for 24 hours；Streptococcus mutans will be inoculated with
Culture dish is put into 37 DEG C of incubation 48h in anaerobism bag, each bacterium is cooked 3 repetitions and tested, and vernier caliper measures each inhibition zone respectively
Two vertical direction diameter (be in cross), be averaged, judge its fungistatic effect.
Table 2：Inhibition zone diameter tests table, unit：mm
As shown in Table 1, the Pediatric Oral Emergency care method nursing oral cavity using the present invention is continued, the index of gingivitis of patient is apparent
Decline, Pediatric Oral Emergency care method of the invention can effectively alleviate gum disease.Embodiment 1-3 is to the Pediatric Oral Emergency conditioning liquid that uses
The plant extracts contained carries out preferably, and by optimizing the dosage of different plants, plant extracts, which has, preferably alleviates children
The effect of gum disease.Also contain Sipunculidae preparation on mice in the Pediatric Oral Emergency conditioning liquid that the present invention uses, it is found that ocean siphon-worm carries
Take object that there are good oral health benefits, it is with obvious effects to alleviating children's gum disease.Embodiment 7-9 is to Pediatric Oral Emergency conditioning liquid
Solubilizer carry out preferred, promote antibacterial in conditioning liquid, the dissolubility of anti-inflammation components and stability.It is of the invention as shown in Table 2
Pediatric Oral Emergency care method nursing oral cavity have good restraining and sterilizing bacteria effect, to common streptococcus mutans, Candida albicans
Bacterium bactericidal effect is notable.
The preferred embodiment of the present invention described in detail above.It should be appreciated that those of ordinary skill in the art without
Creative work is needed according to the present invention can to conceive and makes many modifications and variations.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical solution, all should be in the protection domain being defined in the patent claims.
Claims (10)
1. a kind of Pediatric Oral Emergency care method, which is characterized in that contained using Pediatric Oral Emergency conditioning liquid gargle 5-15 at least once daily
Minute, it is used continuously more than surrounding or surrounding.
2. a kind of Pediatric Oral Emergency care method, which is characterized in that protected at least once daily, every time using 15-30mL Pediatric Oral Emergencies
Reason liquid is used continuously more than surrounding or surrounding, the Pediatric Oral Emergency conditioning liquid includes the group of following weight parts containing gargling 5-15 minutes
Point：0.5-5 parts of plant extracts, 0.3-0.9 parts of xylitol, 0.05-0.5 parts of vitamin C, 0.05-0.2 parts of ethyl alcohol, lauroyl
0.001-0.003 parts of arginine ethyl ester hydrochloride, 0.005-0.02 parts of microcrystalline cellulose, 0.001-0.01 parts of Glucosamine,
0.001-0.01 parts of allantoin, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
3. a kind of Pediatric Oral Emergency care method, which is characterized in that protected at least once daily, every time using 15-30mL Pediatric Oral Emergencies
Reason liquid is used continuously more than surrounding or surrounding, the Pediatric Oral Emergency conditioning liquid includes the group of following weight parts containing gargling 5-15 minutes
Point：0.5-5 parts of plant extracts, 0.01-0.1 parts of Sipunculidae preparation on mice, 0.3-0.9 parts of xylitol, vitamin C 0.05-0.5
Part, 0.05-0.2 parts of ethyl alcohol, 0.001-0.003 parts of lauroyl arginine ethyl ester hydrochloride, 0.005-0.02 parts of microcrystalline cellulose,
0.001-0.01 parts of Glucosamine, 0.001-0.01 parts of allantoin, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
4. the Pediatric Oral Emergency care method according to Claims 2 or 3, which is characterized in that the preparation of the plant extracts
Method is as follows：Radix Ophiopogonis, cassia bark, Herba Andrographitis, Androsace umbellata, Chinese violet are smashed it through into 20-50 mesh sieves respectively, take the wheat after sieving
Winter 6-15g, cassia bark 2-10g, Herba Andrographitis 1-5g, Androsace umbellata 1-5g, Chinese violet 0.5-2.5g, are added to 30-90g mass fractions
It for 65-85%, is pre-heated in 30-40 DEG C of ethanol water, under the conditions of power is 200-300W, frequency is 40-50KHz
Ultrasonic extraction 20-60 minutes is centrifuged 25-45 minutes with 5000-8000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, mistake
100-500 mesh sieves retain filtrate, and filtrate is concentrated by evaporation to 50 DEG C and measures the medicinal extract that relative density is 1.31-1.33, by medicinal extract
It is dry under the conditions of 55-65 DEG C, 0.04-0.06MPa, obtain the plant extracts that dry basis moisture content is 0.8-1.2%.
5. Pediatric Oral Emergency care method according to claim 3, which is characterized in that the preparation of the Sipunculidae preparation on mice
Method is：By the sodium-chloride water solution of 4mol/L, the EDTA aqueous solutions of 6mmol/L, 0.2mol/L Na2HPO3Aqueous solution and
The NaH of 0.2mol/L2PO3Aqueous solution is (80-100) according to volume ratio:(80-100):(3-7):(4-8) is uniformly mixed, and is obtained
Ocean siphon-worm is cleaned, drains surface moisture by extractant, takes the homogenate of 250-260g oceans siphon-worms in being pre-heated to 35-40 DEG C
In 1000-1200g extractants, ultrasonic extraction 45-60 minutes under the conditions of power is 200-250W, frequency is 40-50KHz, so
It is centrifuged 30-45 minutes with 8000-10000 revs/min of rotating speed afterwards, takes the supernatant liquid after centrifugation, crossed 300-500 mesh sieves, obtain
To first-time filtrate and a filter residue, 300-320g ethyl alcohol is added in into first-time filtrate, when temperature is small for 3-4 DEG C of preservation 3-3.5,
300-500 mesh sieves are crossed, obtain secondary filtrate and secondary filter residue, 200-230g ethyl alcohol is added in into secondary filtrate, in 2-3 DEG C of preservation
When 3-3.5 are small, 300-500 mesh sieves are crossed, obtain filtrate three times and three times filter residue, 100-110g ethyl alcohol is added in into filtrate three times,
When 4-5 DEG C of preservation 2-2.5 is small, 300-500 mesh sieves are crossed, four filtrates and four filter residues is obtained, merges secondary filter residue, filters three times
Slag and four filter residues, it is freeze-dried, obtain the Sipunculidae preparation on mice that dry basis moisture content is 2.5-3%.
6. the Pediatric Oral Emergency care method according to Claims 2 or 3, it is characterised in that the solubilizer is pungent capric acid glycerine
One or more mixture in ester, 1,2- propylene glycol, gum arabic.
7. a kind of Pediatric Oral Emergency conditioning liquid, which is characterized in that including following components in parts by weight：0.5-5 parts of plant extracts, wood
0.3-0.9 parts of sugar alcohol, 0.05-0.5 parts of vitamin C, 0.05-0.2 parts of ethyl alcohol, lauroyl arginine ethyl ester hydrochloride 0.001-
0.003 part, 0.005-0.02 parts of microcrystalline cellulose, 0.001-0.01 parts of Glucosamine, 0.001-0.01 parts of allantoin, solubilising
0.005-0.03 parts of agent, 65-85 parts of water.
8. a kind of Pediatric Oral Emergency conditioning liquid, which is characterized in that including following components in parts by weight：0.5-5 parts of plant extracts, sea
Foreign 0.01-0.1 parts of siphon-worm extract, 0.3-0.9 parts of xylitol, 0.05-0.5 parts of vitamin C, 0.05-0.2 parts of ethyl alcohol, bay
0.001-0.003 parts of acyl arginine ethyl ester hydrochloride, 0.005-0.02 parts of microcrystalline cellulose, Glucosamine 0.001-0.01
Part, 0.001-0.01 parts of allantoin, 0.005-0.03 parts of solubilizer, 65-85 parts of water.
9. the preparation method of the Pediatric Oral Emergency conditioning liquid described in claim 7 or 8, which is characterized in that weigh each original by weight
Material is uniformly mixed.
10. application of the Pediatric Oral Emergency conditioning liquid in Pediatric Oral Emergency nursing according to claim 7 or 8.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567967A (en) * | 2019-01-15 | 2019-04-05 | 青岛市口腔医院 | Pediatric Oral Emergency care method and system |
| CN111096932A (en) * | 2018-10-29 | 2020-05-05 | 好维股份有限公司 | Oral care composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430975A (en) * | 2003-01-23 | 2003-07-23 | 上海澳博海洋生物技术开发有限公司 | Extractive of ocean star worm, its preparing method and application |
| CN102000005A (en) * | 2010-11-27 | 2011-04-06 | 天津市顶硕科贸有限公司 | Oral care solution |
| CN106937932A (en) * | 2015-12-29 | 2017-07-11 | 青岛智通四海家具设计研发有限公司 | A kind of Chinese herbal medicine multiple-effect mouthwash |
| CN107412131A (en) * | 2017-08-14 | 2017-12-01 | 武汉美棠口腔有限公司 | Oral nursing liquid and Pediatric Oral Emergency maintenance method |
-
2018
- 2018-02-05 CN CN201810110327.2A patent/CN108113943B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430975A (en) * | 2003-01-23 | 2003-07-23 | 上海澳博海洋生物技术开发有限公司 | Extractive of ocean star worm, its preparing method and application |
| CN102000005A (en) * | 2010-11-27 | 2011-04-06 | 天津市顶硕科贸有限公司 | Oral care solution |
| CN106937932A (en) * | 2015-12-29 | 2017-07-11 | 青岛智通四海家具设计研发有限公司 | A kind of Chinese herbal medicine multiple-effect mouthwash |
| CN107412131A (en) * | 2017-08-14 | 2017-12-01 | 武汉美棠口腔有限公司 | Oral nursing liquid and Pediatric Oral Emergency maintenance method |
Non-Patent Citations (1)
| Title |
|---|
| 刘淑兰等编: "《中国动物药用研究与临床应用》", 31 July 2006, 黑龙江人民出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111096932A (en) * | 2018-10-29 | 2020-05-05 | 好维股份有限公司 | Oral care composition |
| CN111096932B (en) * | 2018-10-29 | 2022-07-15 | 好维股份有限公司 | Oral care composition |
| CN109567967A (en) * | 2019-01-15 | 2019-04-05 | 青岛市口腔医院 | Pediatric Oral Emergency care method and system |
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