CN115364016A - Toothpaste with effect of improving periodontal disease and preparation method thereof - Google Patents

Toothpaste with effect of improving periodontal disease and preparation method thereof Download PDF

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CN115364016A
CN115364016A CN202211186169.1A CN202211186169A CN115364016A CN 115364016 A CN115364016 A CN 115364016A CN 202211186169 A CN202211186169 A CN 202211186169A CN 115364016 A CN115364016 A CN 115364016A
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parts
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toothpaste
periodontal disease
extract
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CN115364016B (en
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吴剑锋
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Yunnan Bakai Biotechnology Co ltd
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Yunnan Bakai Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
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  • Rheumatology (AREA)
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  • Cosmetics (AREA)

Abstract

The invention discloses toothpaste with an effect of improving periodontal disease and a preparation method thereof, wherein the toothpaste comprises the following components in parts by weight: 0.2 to 0.8 portion of tartary buckwheat rutin, 0.5 to 1.0 portion of tea polyphenol, 1 to 3 portions of honeysuckle extract, 0.5 to 1 portion of liquorice extract, 40 to 60 portions of humectant, 2 to 4 portions of surfactant, 3 to 5 portions of thickening agent, 15 to 20 portions of friction agent, 1 to 2 portions of sweetening agent, 0.5 to 1.5 portions of titanium dioxide, 1 to 2 portions of essence and 10 to 25 portions of water; the toothpaste effectively inhibits pathogenic bacteria of periodontal disease through the combined action of the components, promotes the repair of periodontal tissue injury, relieves and alleviates the problems of red swelling and bleeding of gum, effectively improves the periodontal disease, and finally achieves the purpose of treating periodontal disease.

Description

Toothpaste with effect of improving periodontal disease and preparation method thereof
Technical Field
The invention relates to the technical field of toothpaste preparation, in particular to toothpaste with an effect of improving periodontal disease and a preparation method thereof.
Background
Gingivitis is an early and reversible inflammatory lesion of gingival tissue, which is one of periodontal diseases. Gingivitis may be developed if bleeding occurs during brushing, or if blood stains are found on the toothbrush. Furthermore, if a bloodstain is found on the teeth when biting a hard object such as apple or steamed bread, inflammation of the gums may also be evidenced. Because gingivitis is reversible, the plaque and tartar can be removed from the teeth by effective brushing, or clinical washing of the teeth, thereby restoring the normal gums. Clinically, the most common oral diseases are caries and periodontal disease, which in turn includes gingivitis and periodontitis.
At present, most of the existing toothpastes are used for removing stains and improving tooth brightness, and few toothpastes have the effects of removing stains and improving periodontal diseases, so that the provision of a toothpaste with an excellent effect of improving periodontal diseases is particularly critical.
Disclosure of Invention
The invention aims to provide toothpaste with an effect of improving periodontal diseases and a preparation method thereof.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the invention provides toothpaste with an effect of improving periodontal diseases, which comprises the following components in parts by weight:
0.2 to 0.8 portion of tartary buckwheat rutin, 0.5 to 1.0 portion of tea polyphenol, 1 to 3 portions of honeysuckle extract, 0.5 to 1 portion of liquorice extract, 40 to 60 portions of humectant, 2 to 4 portions of surfactant, 3 to 5 portions of thickening agent, 15 to 20 portions of friction agent, 1 to 2 portions of sweetening agent, 0.5 to 1.5 portions of titanium dioxide, 1 to 2 portions of essence and 10 to 25 portions of water.
Preferably, the toothpaste comprises the following components in parts by weight:
0.5 part of tartary buckwheat rutin, 0.8 part of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of liquorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickening agent, 18 parts of friction agent, 1.5 parts of sweetening agent, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water.
Preferably, the humectant is sorbitol and/or polyethylene glycol.
Preferably, the surfactant is sodium lauryl sulfate and/or sodium lauryl sulfate.
Preferably, the thickener is at least one of xanthan gum, hydroxyethyl cellulose and carbomer resin.
Preferably, the abrasive is calcium carbonate or hydrated silica.
Preferably, the sweetener is saccharin sodium or erythritol.
Preferably, the honeysuckle extract and the licorice extract are aqueous extracts.
The second aspect of the present invention provides a preparation method of the above toothpaste, comprising the steps of:
(a) Weighing the components in parts by weight;
(b) Mixing the components, stirring to obtain paste, and packaging to obtain the toothpaste.
Compared with the prior art, the invention has the beneficial effects that at least:
according to the toothpaste, tartary buckwheat rutin is adopted to improve the microcirculation of periodontal tissues and is used for cooperating with tea polyphenol and honeysuckle extracts to achieve excellent antibacterial and anti-inflammatory effects, and licorice is used for promoting the cell activity in the periodontal tissues and harmonizing the effects of the components, so that the pathogenic bacteria of periodontal diseases are effectively inhibited under the combined action of the components, the damage repair of the periodontal tissues is promoted, the problems of redness and swelling and bleeding of gingiva are relieved and relieved, the symptoms of periodontal diseases are effectively improved, and the purpose of treating periodontal diseases is finally achieved.
Detailed Description
The following describes embodiments of the present invention in detail with reference to the following embodiments. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
The following examples employ the following raw materials:
the tartary buckwheat rutin is prepared by the following method:
(a) Selecting fresh tartary buckwheat flowers in a flowering period, and then carrying out freeze grinding on the tartary buckwheat flowers for 0.2h to obtain tartary buckwheat powder;
(b) Under the ultrasonic condition of 600W, according to the mass ratio of the tartary buckwheat powder to the extracting solution of 1: 10, placing the tartary buckwheat powder into the extracting solution with the pH value of 8.8, extracting for 0.5h at room temperature, and filtering to obtain the tartary buckwheat extracting solution, wherein the extracting solution comprises the following components: ethanol, sodium sulfite and water; the volume concentration of ethanol in the extracting solution is 60 percent, and the mass concentration of sodium sulfite is 0.2 percent;
(c) Adjusting the pH value of the tartary buckwheat extracting solution to 3.5, standing for 5 hours, and filtering to obtain a tartary buckwheat rutin crude product;
(d) And (3) washing the buckwheat rutin crude product with water, and drying in vacuum to obtain the buckwheat rutin.
Water extract of honeysuckle: obtained by ordinary commercial purchase;
tea polyphenol: obtained by ordinary commercial purchase;
licorice aqueous extract: commonly commercially available.
Example 1
1. Toothpaste with effect of improving periodontal disease
The toothpaste with the effect of improving periodontal disease comprises the following components in parts by weight:
0.2 part of tartary buckwheat rutin, 1.0 part of tea polyphenol, 3 parts of honeysuckle extract, 0.5 part of liquorice extract, 40 parts of humectant, 2 parts of surfactant, 5 parts of thickening agent, 20 parts of friction agent, 1 part of sweetener, 1.5 parts of titanium dioxide, 2 parts of essence and 25 parts of water;
wherein the humectant is polyethylene glycol;
the surfactant is sodium dodecyl sulfate;
the thickening agent is carbomer resin;
the abrasive is calcium carbonate;
the sweetener is saccharin sodium;
2. preparation method
The preparation method of the toothpaste with the efficacy of improving periodontal disease comprises the following steps:
(a) Weighing the components in parts by weight;
(b) Mixing the components, stirring to obtain paste, and packaging to obtain the toothpaste.
Example 2
1. Toothpaste with effect of improving periodontal disease
The toothpaste with the effect of improving periodontal diseases comprises the following components in parts by weight:
0.8 part of tartary buckwheat rutin, 0.5 part of tea polyphenol, 1 part of honeysuckle extract, 1 part of liquorice extract, 60 parts of humectant, 4 parts of surfactant, 3 parts of thickening agent, 15 parts of friction agent, 2 parts of sweetener, 0.5 part of titanium dioxide, 1 part of essence and 10 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickening agent is xanthan gum;
the abrasive is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the effect of improving periodontal disease comprises the following steps:
(a) Weighing the components in parts by weight;
(b) Mixing the components, stirring to obtain paste, and packaging to obtain the toothpaste.
Example 3
1. Toothpaste with effect of improving periodontal disease
The toothpaste with the effect of improving periodontal disease comprises the following components in parts by weight:
0.5 part of tartary buckwheat rutin, 0.8 part of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of liquorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickening agent, 18 parts of friction agent, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickening agent is hydroxyethyl cellulose;
the abrasive is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the efficacy of improving periodontal disease comprises the following steps:
(a) Weighing the components in parts by weight;
(b) Mixing the above materials, stirring to obtain paste, and packaging to obtain the final product.
Comparative example 1
1. Toothpaste with effect of improving periodontal disease
The toothpaste with the effect of improving periodontal diseases comprises the following components in parts by weight:
1.3 parts of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of liquorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickener, 18 parts of abrasive, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickening agent is hydroxyethyl cellulose;
the abrasive is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the effect of improving periodontal disease comprises the following steps:
(a) Weighing the components in parts by weight;
(b) Mixing the above materials, stirring to obtain paste, and packaging to obtain the final product.
Comparative example 2
1. Toothpaste with effect of improving periodontal disease
The toothpaste with the effect of improving periodontal disease comprises the following components in parts by weight:
1.3 parts of tartary buckwheat rutin, 2 parts of honeysuckle extract, 0.8 part of liquorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickening agent, 18 parts of friction agent, 1.5 parts of sweetening agent, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickening agent is hydroxyethyl cellulose;
the abrasive is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the efficacy of improving periodontal disease comprises the following steps:
(a) Weighing the components in parts by weight;
(b) Mixing the components, stirring to obtain paste, and packaging to obtain the toothpaste.
Examples of the experiments
90 gingivitis patients are selected, wherein the ages of the gingivitis patients are 8-24 years old, 42 gingivitis patients are male gingivitis patients and 38 gingivitis patients are not treated within 3 weeks; randomly dividing into 3 groups, each group comprises 30 persons, the first group adopts the toothpaste prepared in example 3 to brush teeth, the second group adopts the toothpaste prepared in comparative example 1 to brush teeth, and the third group adopts the toothpaste prepared in comparative example 2 to brush teeth, wherein the toothbrushing is carried out in the morning and the evening respectively, each time is not less than 3 minutes, and a uniform toothbrush is adopted; no other drugs were used for treatment during the experiment; brushing teeth for 20 days;
the gingival index and plaque index of each patient were measured before and after brushing with the example and the comparative toothpaste according to the Loe-silness standard, and the results are shown in table 1:
TABLE 1 gingival and plaque indices before and after treatment of different groups
Figure BDA0003867758120000071
As can be seen from Table 1:
the toothpaste prepared by the embodiment of the invention and the comparative example have the effect of improving gingivitis, however, the toothpaste prepared by the invention has more excellent treatment effect compared with the comparative example.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.

Claims (9)

1. The toothpaste with the effect of improving periodontal diseases is characterized by comprising the following components in parts by weight:
0.2 to 0.8 portion of tartary buckwheat rutin, 0.5 to 1.0 portion of tea polyphenol, 1 to 3 portions of honeysuckle extract, 0.5 to 1 portion of liquorice extract, 40 to 60 portions of humectant, 2 to 4 portions of surfactant, 3 to 5 portions of thickening agent, 15 to 20 portions of friction agent, 1 to 2 portions of sweetening agent, 0.5 to 1.5 portions of titanium dioxide, 1 to 2 portions of essence and 10 to 25 portions of water.
2. The toothpaste according to claim 1, wherein the toothpaste comprises the following components in parts by weight:
0.5 part of tartary buckwheat rutin, 0.8 part of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of liquorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickening agent, 18 parts of friction agent, 1.5 parts of sweetening agent, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water.
3. The toothpaste of claim 1, wherein the humectant is sorbitol and/or polyethylene glycol.
4. The toothpaste according to claim 1, wherein the surfactant is sodium lauryl sulfate and/or sodium lauryl sulfate.
5. The toothpaste of claim 1, wherein said thickening agent is at least one of xanthan gum, hydroxyethyl cellulose, and carbomer resin.
6. The toothpaste of claim 1, wherein the abrasive is calcium carbonate or hydrated silica.
7. The toothpaste according to claim 1, wherein the sweetener is sodium saccharin or erythritol.
8. The toothpaste of claim 1, wherein the honeysuckle extract and the licorice extract are aqueous extracts.
9. A method of preparing a toothpaste as claimed in any one of claims 1 to 8, comprising the steps of:
(a) Weighing the components in parts by weight;
(b) Mixing the above materials, stirring to obtain paste, and packaging to obtain the final product.
CN202211186169.1A 2022-09-27 2022-09-27 Toothpaste with periodontal disease improving effect and preparation method thereof Active CN115364016B (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039452A2 (en) * 2001-11-06 2003-05-15 The Quigley Corporation Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US20110256072A1 (en) * 2008-11-28 2011-10-20 Ezaki Glico Co., Ltd. Food and composition each comprising phosphorylated saccharide, polyphenol and fluoride
CN103083209A (en) * 2013-01-25 2013-05-08 中山大学 Master slice for mouthwash and preparation method thereof
CN107929173A (en) * 2017-12-29 2018-04-20 南宁圣特生物科技有限公司 Buckwheat Chinese mugwort tea seed essential oil and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039452A2 (en) * 2001-11-06 2003-05-15 The Quigley Corporation Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US20110256072A1 (en) * 2008-11-28 2011-10-20 Ezaki Glico Co., Ltd. Food and composition each comprising phosphorylated saccharide, polyphenol and fluoride
CN103083209A (en) * 2013-01-25 2013-05-08 中山大学 Master slice for mouthwash and preparation method thereof
CN107929173A (en) * 2017-12-29 2018-04-20 南宁圣特生物科技有限公司 Buckwheat Chinese mugwort tea seed essential oil and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李谣: "苦荞抗氧化活性研究", 中国酿造, vol. 6, no. 32, pages 24 - 27 *

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