CN114557942A - Oral care tooth powder and preparation method and application thereof - Google Patents

Oral care tooth powder and preparation method and application thereof Download PDF

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Publication number
CN114557942A
CN114557942A CN202210213030.5A CN202210213030A CN114557942A CN 114557942 A CN114557942 A CN 114557942A CN 202210213030 A CN202210213030 A CN 202210213030A CN 114557942 A CN114557942 A CN 114557942A
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parts
oral care
vitamin
calcium carbonate
raw materials
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曹云鹤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/62—Nymphaeaceae (Water-lily family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention provides an oral care dentifrice and a preparation method and application thereof, and relates to the technical field of oral care. An oral care dentifrice comprises the following raw materials in parts by weight: 0.5-1 part of calcium carbonate, 0.01-0.1 part of vitamin C, 0.001-0.003 part of calcium hydrophosphate dihydrate, 5-20 parts of pseudo-ginseng, 3-15 parts of lotus leaf, 5-15 parts of rhizoma cyperi, 2-10 parts of pepper, 5-15 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 5-20 parts of angelica sinensis, 10-20 parts of rhizoma cimicifugae, 10-25 parts of burmannia, 10-25 parts of prepared rehmannia root and 5-15 parts of schizonepeta. The invention enhances the treatment effect on periodontitis, red and swollen gum, loose teeth and gingival atrophy by the mutual synergy of the medicines.

Description

Oral care tooth powder and preparation method and application thereof
Technical Field
The invention relates to the technical field of oral care, in particular to oral care dentifrice and a preparation method and application thereof.
Background
Dentifrice is the most commonly used dental cleanser for people. In ancient times, various tools were used to wipe teeth for tooth brushing, and various dentifrices were added, most commonly salt, i.e., the precursor of dentifrice.
Periodontal disease refers to a disease occurring in the supporting tissues of the tooth (periodontal tissue), and includes two major types, i.e., gum disease involving only the gingival tissue and periodontitis affecting the deep periodontal tissues (periodontal ligament, alveolar bone, and cementum). Periodontal disease is a common oral disease, one of the major causes of tooth loss in adults, and is a major oral disease that compromises human teeth and general health. According to the introduction of the dentist: "periodontitis is a major cause of gingival atrophy, which is an important factor in tooth loss".
The existing toothpaste and tooth powder on the market only have a temporary curative effect on periodontal diseases, and the treatment effect is poor.
Disclosure of Invention
The invention aims to provide the oral care dentifrice which has the advantage of good effect of treating gum diseases.
Another object of the present invention is to provide a method for preparing an oral care dentifrice, so as to obtain the oral care dentifrice having a good effect of treating gum diseases.
The invention also aims to provide application of the oral care dentifrice in preparing a medicament for treating gum diseases.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides an oral care dentifrice which comprises the following raw materials in parts by weight: 0.5-1 part of calcium carbonate, 0.01-0.1 part of vitamin C, 0.001-0.003 part of calcium hydrophosphate dihydrate, 5-20 parts of pseudo-ginseng, 3-15 parts of lotus leaf, 5-15 parts of rhizoma cyperi, 2-10 parts of pepper, 5-15 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 5-20 parts of angelica sinensis, 10-20 parts of rhizoma cimicifugae, 10-25 parts of burmannia, 10-25 parts of prepared rehmannia root and 5-15 parts of schizonepeta.
In another aspect, an embodiment of the present application provides a method for preparing an oral care dentifrice, including the steps of:
drying the raw materials except the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate, and mixing to obtain a mixture;
crushing the mixture and grinding into powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
In a further aspect, the present application provides a use of an oral care dentifrice for preparing a medicament for treating a gum disease.
Pseudo-ginseng: sweet, slightly bitter and warm in nature; it enters liver and stomach meridians. Has effects of removing blood stasis, stopping bleeding, promoting blood circulation, and relieving pain. It is used for treating various bleeding, swelling and pain due to blood stasis, traumatic injury, etc.
Lotus leaf: bitter taste and mild nature. It enters liver, spleen and stomach meridians. Has the effects of clearing summer-heat, eliminating dampness, ascending the body fluid, clearing yang, cooling blood and stopping bleeding. Can be used for treating summer heat, polydipsia, summer damp diarrhea, spleen deficiency diarrhea, hematemesis, epistaxis, hematochezia, metrorrhagia, and metrostaxis.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral in nature; it enters liver meridian. Has effects of dispersing stagnated liver qi, relieving qi stagnation, regulating menstruation, relieving pain, regulating qi-flowing, and regulating middle warmer. Can be used for treating hypochondriac pain due to stagnation of liver-qi, abdominal pain, menoxenia, dysmenorrhea, breast pain, and abdominal pain due to stagnation of qi.
Chinese prickly ash: pungent taste and warm nature; it enters spleen, stomach and kidney meridians. Has effects of warming middle-jiao, relieving pain, killing parasites and relieving itching. Can be used for treating middle cold abdominal pain, vomiting and diarrhea due to cold-dampness, abdominal pain due to parasitic infestation, eczema, pruritus, pudendal pruritus of women, etc.
Radix angelicae: pungent taste and warm nature; it enters lung, stomach and large intestine meridians. Has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind and relieving itching. Can be used for treating wind-cold type common cold, headache, toothache, arthralgia, nasosinusitis, leukorrhagia, skin sore, carbuncle, skin pruritus, etc.
Ligusticum wallichii: pungent taste and warm nature; it enters liver, gallbladder and pericardium meridians. Has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Can be used for treating thoracic obstruction and heart pain due to heart vessel stagnation, hypochondriac distending pain due to stagnation of qi due to liver depression, thoracic and hypochondriac pricking pain due to liver blood stagnation, traumatic injury due to blood stasis stagnation, pyocutaneous disease and swelling pain, menoxenia, amenorrhea and dysmenorrhea, puerperal blood stasis and pain, lochiorrhea, various headaches, and rheumatic arthralgia.
Chinese angelica: sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians. Has the effects of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating blood deficiency, sallow complexion, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, superficial infection, pyocutaneous disease, intestinal dryness, constipation, etc.
Cimicifugae foetidae: pungent, slightly sweet and slightly cold in nature; it enters lung and spleen meridians. Has the effects of relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang qi. Can be used for treating exterior syndrome due to exogenous pathogenic factors, measles without adequate eruption, toothache, aphtha, sore throat, warm toxic, macula, qi deficiency collapse, organ prolapse, metrorrhagia, and hemorrhage.
Burley eggplant: pungent taste and mild nature; it enters liver meridian. Has the effects of clearing away heat and toxic materials, and relieving swelling and pain. Can be used for treating acute contagious conjunctivitis, nebula, skin sore, and toothache due to pathogenic fire.
Prepared rehmannia root: sweet in flavor and slightly warm in nature; it enters liver and kidney meridians. Has effects in replenishing blood, nourishing yin, replenishing essence, and replenishing marrow. Can be used for treating blood deficiency, sallow complexion, menoxenia, metrorrhagia, metrostaxis, kidney yin deficiency, soreness of waist and knees, night sweat, spermatorrhea, essence and blood deficiency, dizziness, premature gray hair, etc.
Herba schizonepetae: pungent taste and mild nature; it enters lung and liver meridians. Has the effects of dispelling pathogenic wind, relieving exterior syndrome, promoting eruption, eliminating sore, and stopping bleeding. It is indicated for exterior syndrome of exogenous pathogenic factors, measles without adequate eruption, rubella with pruritus, initial stage of pyocutaneous disease with exterior syndrome, hematemesis and epistaxis.
Bitter bamboo juice: bitter taste and cold nature. It enters heart, liver and spleen meridians. Has the effects of clearing away fire, removing toxic substances and benefiting orifices. Can be used for treating conjunctival congestion, toothache, and aphtha.
And (3) calabash tear: bitter, salty and cold in nature; it enters lung and stomach meridians. Has the effects of clearing away heat and toxic materials, eliminating phlegm and softening hard masses. Can be used for treating sore throat, toothache, ulcerative gingivitis, otitis media, scrofula, and gastralgia.
Alum: astringent, sour, cold in nature; it enters lung, spleen and liver meridians. Externally used for detoxifying and killing parasites, eliminating dampness and relieving itching; orally administered to stop bleeding and stop diarrhea, dispel phlegm and open and close. Can be used for treating scabies, tinea, eczema, pruritus, pyocutaneous disease, chronic diarrhea, dysentery, hematemesis, hematochezia, apoplexy, phlegm syncope, mania, epilepsy, etc.
The inventor thinks that the teeth are the targets of the kidney, and the kidney deficiency causes the teeth to shake and break, and the teeth are inflamed by the mutual fire and are painful; when damp-heat exists in the intestines and stomach and goes up between the gums, it is suitable for wind-cold or cold-retained, so that the damp-heat cannot be reached externally, and it also causes toothache. The treatment should purge damp-heat, tonify kidney deficiency, and keep the gingival environment clean to avoid food residue left between teeth.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the invention takes cimicifugae foetidae and buronia as monarch drugs to play roles in clearing heat and eliminating dampness, relieving pain and warming and invigorating kidney yang, and takes prepared rehmannia root, lotus leaf and ligusticum wallichii as ministerial drugs to play an auxiliary role, thereby playing roles in relieving pain, eliminating dampness, dispelling wind and tonifying kidney essence; the schizonepeta, the pepper, the pseudo-ginseng and the angelica dahurica are used as adjuvant drugs to play roles in warming the middle-jiao to relieve pain, killing insects, relieving pain, eliminating dampness, reducing swelling and relieving exterior syndrome; and rhizoma cyperi is used as a guiding drug to achieve the effects of regulating menstruation, relieving pain and regulating qi. The efficacy of the medicines can enter the body, and the medicines are mutually synergistic, so that the treatment effect on periodontitis, red and swollen gums, loose teeth and gingival atrophy is enhanced. The added calcium carbonate and the calcium hydrogen phosphate dihydrate have certain structural strength, can remove pigment and tartar on the surface of teeth when in use, and simultaneously can not damage tooth enamel and protect the surface of the teeth because the strength is not high. The added vitamin C can repair oral mucosa, protect oral integrity and maintain the inside of the oral cavity.
The preparation method is simple, convenient and fast, has high production efficiency, can realize batch production, and is suitable for popularization.
When the dentifrice is used, a proper amount of the dentifrice is only needed to be dipped and coated on teeth, the surface of the teeth can be rubbed if needed, and after 2-10min, the dentifrice is rinsed with water and then is spit out.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides an oral care dentifrice which comprises the following raw materials in parts by weight: 0.5-1 part of calcium carbonate, 0.01-0.1 part of vitamin C, 0.001-0.003 part of calcium hydrophosphate dihydrate, 5-20 parts of pseudo-ginseng, 3-15 parts of lotus leaf, 5-15 parts of rhizoma cyperi, 2-10 parts of pepper, 5-15 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 5-20 parts of angelica sinensis, 10-20 parts of rhizoma cimicifugae, 10-25 parts of burmannia, 10-25 parts of prepared rehmannia root and 5-15 parts of schizonepeta. The invention takes the cimicifugae foetidae and the buronia as monarch drugs to play the roles of eliminating dampness, relieving pain and warming and invigorating kidney yang, and takes the prepared rehmannia root, the lotus leaf and the ligusticum wallichii as ministerial drugs to play the role of assisting, thereby playing the roles of relieving pain, eliminating dampness, dispelling wind and tonifying kidney essence; the schizonepeta, the pepper, the pseudo-ginseng and the angelica dahurica are used as adjuvant drugs to play roles in warming middle-jiao and relieving pain, killing insects, relieving pain, eliminating dampness, reducing swelling and relieving exterior syndrome; and rhizoma cyperi is used as a guiding drug to achieve the effects of regulating menstruation, relieving pain and regulating qi. The efficacy of the medicines can enter the body, and the medicines are mutually synergistic, so that the treatment effect on periodontitis, red and swollen gums, loose teeth and gingival atrophy is enhanced. The added calcium carbonate and the calcium hydrophosphate dihydrate have certain structural strength, can remove pigment and tartar on the surface of teeth when in use, and simultaneously can not damage tooth enamel and protect the surface of the teeth because the strength is not high. The added vitamin C can repair oral mucosa, protect oral integrity and maintain the inside of the oral cavity.
In some embodiments of the present invention, the oral care dentifrice comprises the following raw materials in parts by weight: 0.6-0.9 part of calcium carbonate, 0.04-0.08 part of vitamin C, 0.001-0.002 part of calcium hydrophosphate dihydrate, 10-15 parts of pseudo-ginseng, 5-13 parts of lotus leaf, 8-13 parts of rhizoma cyperi, 4-8 parts of pepper, 8-13 parts of radix angelicae, 12-18 parts of ligusticum wallichii, 10-18 parts of angelica sinensis, 12-18 parts of rhizoma cimicifugae, 12-20 parts of burmannia, 15-20 parts of prepared rehmannia root and 8-13 parts of schizonepeta. With the proportion, the treatment effect is better.
In some embodiments of the present invention, the oral care dentifrice comprises the following raw materials in parts by weight: 0.8 part of calcium carbonate, 0.06 part of vitamin C, 0.002 part of calcium hydrogen phosphate dihydrate, 13 parts of pseudo-ginseng, 9 parts of lotus leaf, 10 parts of rhizoma cyperi, 6 parts of pepper, 10 parts of radix angelicae, 15 parts of ligusticum wallichii, 15 parts of angelica sinensis, 15 parts of rhizoma cimicifugae, 18 parts of burmannia, 18 parts of prepared rehmannia root and 10 parts of schizonepeta.
In some embodiments of the present invention, the oral care dentifrice further comprises the following raw materials in parts by weight: 5-15 parts of bitter bamboo juice, 1-10 parts of calanolia chinensis tear and 5-10 parts of alum. The bitter bamboo juice can clear fire, so as to accelerate the recovery of gum diseases, the calanolia root tears can clear away heat and toxic materials, the alum can kill insects and dry dampness, and the common action can strengthen the treatment effect.
In some embodiments of the present invention, the oral care dentifrice comprises the following raw materials in parts by weight: 0.8 part of calcium carbonate, 0.06 part of vitamin C, 0.002 part of calcium hydrogen phosphate dihydrate, 13 parts of pseudo-ginseng, 9 parts of lotus leaf, 10 parts of rhizoma cyperi, 6 parts of pepper, 10 parts of radix angelicae, 15 parts of ligusticum wallichii, 15 parts of angelica sinensis, 15 parts of rhizoma cimicifugae, 18 parts of burmannia, 18 parts of prepared rehmannia root, 10 parts of schizonepeta, 10 parts of bitter bamboo juice, 6 parts of calanolia and 8 parts of alum.
In some embodiments of the present invention, the oral care dentifrice further comprises 0.002 to 0.004 parts by weight of a flavoring.
The invention also provides a preparation method of the oral care dentifrice, which comprises the following steps:
drying the raw materials except the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate, and mixing to obtain a mixture;
crushing the mixture, and grinding into powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product. The preparation method is simple, convenient and fast, has high production efficiency, can realize batch production, and is suitable for popularization.
In some embodiments of the present invention, the drying temperature is 55-65 ℃.
In some embodiments of the present invention, the powder has a size of 300-350 mesh.
The invention also provides application of the oral care dentifrice in preparing a medicament for treating gum diseases.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 5g of calcium carbonate, 0.1g of vitamin C, 0.01g of calcium hydrogen phosphate dihydrate, 50g of pseudo-ginseng, 30g of lotus leaf, 50g of rhizoma cyperi, 20g of pepper, 50g of radix angelicae, 100g of ligusticum wallichii, 50g of angelica sinensis, 100g of rhizoma cimicifugae, 100g of burmannia, 100g of prepared rehmannia root and 50g of schizonepeta.
Drying the raw materials except for the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate at 55 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 300-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 2
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 6g of calcium carbonate, 0.4g of vitamin C, 0.01g of calcium hydrophosphate dihydrate, 100g of pseudo-ginseng, 50g of lotus leaf, 80g of rhizoma cyperi, 40g of pepper, 80g of radix angelicae, 120g of ligusticum wallichii, 100g of angelica sinensis, 120g of rhizoma cimicifugae, 120g of burmannia, 150g of prepared rehmannia root and 80g of schizonepeta.
Drying the raw materials except for the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate at 58 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 320-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 3
A preparation method of an oral care dentifrice comprises the following steps:
raw materials: 8g of calcium carbonate, 0.6g of vitamin C, 0.02g of calcium hydrogen phosphate dihydrate, 130g of pseudo-ginseng, 90g of lotus leaf, 100g of rhizoma cyperi, 60g of pepper, 100g of radix angelicae, 150g of ligusticum wallichii, 150g of angelica sinensis, 150g of rhizoma cimicifugae, 180g of burmannia, 180g of prepared rehmannia root and 100g of schizonepeta.
Drying the raw materials except for the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate at 60 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 330-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 4
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 9g of calcium carbonate, 0.8g of vitamin C, 0.02g of calcium hydrophosphate dihydrate, 150g of pseudo-ginseng, 130g of lotus leaf, 130g of rhizoma cyperi, 80g of pepper, 130g of radix angelicae, 180g of ligusticum wallichii, 180g of angelica sinensis, 180g of rhizoma cimicifugae, 200g of burmannia, 200g of prepared rehmannia root and 130g of schizonepeta.
Drying the raw materials except calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate at 60 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 340-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 5
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 10g of calcium carbonate, 1g g of vitamin C, 0.03g of calcium hydrogen phosphate dihydrate, 200g of pseudo-ginseng, 150g of lotus leaf, 150g of rhizoma cyperi, 100g of pepper, 150g of angelica dahurica, 200g of ligusticum wallichii, 200g of angelica sinensis, 200g of rhizoma cimicifugae, 250g of burmannia, 250g of prepared rehmannia root and 150g of schizonepeta.
Drying the raw materials except for calcium carbonate, vitamin C and calcium hydrophosphate dihydrate at 65 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 350-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 6
This example is substantially the same as example 1, except that: also comprises 50g of bitter bamboo juice, 10g of calanolia chinensis and 50g of alum.
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 5g of calcium carbonate, 0.1g of vitamin C, 0.01g of calcium hydrogen phosphate dihydrate, 50g of pseudo-ginseng, 30g of lotus leaf, 50g of rhizoma cyperi, 20g of pepper, 50g of radix angelicae, 100g of ligusticum wallichii, 50g of angelica sinensis, 100g of rhizoma cimicifugae, 100g of burmannia, 100g of prepared rehmannia root and 50g of schizonepeta. 50g of bitter bamboo juice, 10g of calanolia chinensis and 50g of alum.
Drying the raw materials except for calcium carbonate, vitamin C and calcium hydrophosphate dihydrate at 55 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding the crushed mixture into 300-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 7
This example is substantially the same as example 2, except that: also comprises bitter bamboo juice 80g, calanolia peel 30g and alum 60 g.
A preparation method of an oral care dentifrice comprises the following steps:
raw materials: 6g of calcium carbonate, 0.4g of vitamin C, 0.01g of calcium hydrogen phosphate dihydrate, 100g of pseudo-ginseng, 50g of lotus leaf, 80g of rhizoma cyperi, 40g of pepper, 80g of radix angelicae, 120g of ligusticum wallichii, 100g of angelica sinensis, 120g of rhizoma cimicifugae, 120g of burmannia, 150g of prepared rehmannia root, 80g of schizonepeta, 80g of bitter bamboo juice, 30g of calabash tear and 60g of alum.
Drying the raw materials except for the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate at 58 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 320-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 8
This example is substantially the same as example 3, except that: also comprises 100g of bitter bamboo juice, 60g of calanolia chinensis tear and 80g of alum.
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 8g of calcium carbonate, 0.6g of vitamin C, 0.02g of calcium hydrogen phosphate dihydrate, 130g of pseudo-ginseng, 90g of lotus leaf, 100g of rhizoma cyperi, 60g of pepper, 100g of radix angelicae, 150g of ligusticum wallichii, 150g of angelica sinensis, 150g of rhizoma cimicifugae, 180g of burmannia, 180g of prepared rehmannia root, 100g of schizonepeta, 100g of bitter bamboo juice, 60g of calabash tear and 80g of alum.
Drying the raw materials except calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate at 60 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 330-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 9
This example is substantially the same as example 4, except that: also comprises 130g of bitter bamboo juice, 80g of calanolia lacryma and 90g of alum.
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 9g of calcium carbonate, 0.8g of vitamin C, 0.02g of calcium hydrophosphate dihydrate, 150g of pseudo-ginseng, 130g of lotus leaf, 130g of rhizoma cyperi, 80g of pepper, 130g of angelica dahurica, 180g of ligusticum wallichii, 180g of angelica sinensis, 180g of rhizoma cimicifugae, 200g of burmannia, 200g of prepared rehmannia root, 130g of schizonepeta, 130g of bitter bamboo juice, 80g of calabash tear and 90g of alum.
Drying the raw materials except calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate at 60 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 340-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Example 10
This example is substantially the same as example 5, except that: also comprises bitter bamboo juice 150g, calanolia peel 100g and alum 100 g.
A preparation method of oral care dentifrice comprises the following steps:
raw materials: 10g of calcium carbonate, 1g g of vitamin C, 0.03g of calcium hydrogen phosphate dihydrate, 200g of pseudo-ginseng, 150g of lotus leaf, 150g of rhizoma cyperi, 100g of pepper, 150g of angelica dahurica, 200g of ligusticum wallichii, 200g of angelica sinensis, 200g of rhizoma cimicifugae, 250g of burmannia, 250g of prepared rehmannia root, 150g of schizonepeta, 150g of bitter bamboo juice, 100g of calabash tear and 100g of alum.
Drying the raw materials except for calcium carbonate, vitamin C and calcium hydrophosphate dihydrate at 65 ℃, and mixing to obtain a mixture;
crushing the mixture, and grinding into 350-mesh powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
Comparative example 1
This comparative example is essentially the same as example 3, except that: replacing Mylabris with Artemisia sphaerocephala.
Comparative example 2
This comparative example is essentially the same as example 3, except that: cimicifuga foetida is not used.
Examples of the experiments
216 patients with periodontitis were selected, with an age between 38-65 years. The patients were randomly divided into 8 groups of 27 patients, and treated with the dentifrices prepared in examples 1-5, 8 and comparative examples 1-2 twice a day, each time with a toothbrush dipping an appropriate amount of dentifrices on teeth and affected parts, the toothbrush was gently brushed for 3min, and 7 days was 1 treatment course. The results are shown in Table 1.
After 2 treatment sessions, patient status was collected.
And (3) curing: tooth loss, gingival atrophy cessation, gingival swelling and gingival bleeding.
The effect is shown: improved tooth loosening, improved gingival atrophy, reduced gingival swelling, or reduced gingival bleeding.
And (4) invalidation: the symptoms are not reduced or worsened compared to the previous ones.
TABLE 1
Figure BDA0003533411640000141
Figure BDA0003533411640000151
In combination with table 1, it can be seen that the dentifrice prepared by the present application has a remarkable therapeutic effect on periodontitis, and comparing groups 3 and 6, it can be seen that group 6 has a better effect; comparing the 3 groups and the 7-8 groups, it can be seen that the effect on the treatment effect of the dentifrice, whether by replacement or deletion of the drug, is very large.
The following are typical cases:
1. zhao, male, 47 years old, more tartar, red and swollen gums, bleeding during daily tooth brushing, and more bad breath, the dentifrice prepared in example 3 is selected for treatment, twice a day in the morning and at night, a proper amount of dentifrice is dipped and coated on teeth and affected parts every time, the toothbrush is gently brushed for 3min, 8 days are continued, the gums are swollen, the tooth brushing does not bleed any more, the bad breath disappears, the tartar is reduced more, and the tooth condition is better.
2. Certain fructus muelleri, female, 60 years old, loose teeth, weak chewing, periodontal swelling and pus discharge, and serious halitosis, the dentifrice prepared in example 7 is selected for treatment, twice a day in the morning and at night, a proper amount of dentifrice is dipped and coated on teeth and affected parts each time, the toothbrush is used for brushing gently for 3min and 14 days, the loose teeth condition is improved, the chewing is strong, the periodontal swelling is relieved, no pus discharge exists, and the halitosis condition is improved.
In conclusion, the invention takes the cimicifuga foetida and buronia as monarch drugs to play roles in clearing heat and eliminating dampness, relieving pain and warming and invigorating kidney yang, and takes the prepared rehmannia root, the lotus leaf and the ligusticum wallichii as ministerial drugs to play an auxiliary role, thereby playing roles in relieving pain, eliminating dampness, dispelling wind and tonifying kidney essence; the schizonepeta, the pepper, the pseudo-ginseng and the angelica dahurica are used as adjuvant drugs to play roles in warming middle-jiao and relieving pain, killing insects, relieving pain, eliminating dampness, reducing swelling and relieving exterior syndrome; and rhizoma cyperi is used as a guiding drug to achieve the effects of regulating menstruation, relieving pain and regulating qi. The medicine efficacy is strengthened, the medicine efficacy is mutually synergistic, and the treatment effect on periodontitis, red and swollen gum, loose teeth and gingival atrophy is enhanced. The added calcium carbonate and the calcium hydrogen phosphate dihydrate have certain structural strength, can remove pigment and tartar on the surface of teeth when in use, and simultaneously can not damage tooth enamel and protect the surface of the teeth because the strength is not high. The added vitamin C can repair oral mucosa, protect oral integrity and maintain the inside of the oral cavity.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. An oral care dentifrice is characterized by comprising the following raw materials in parts by weight: 0.5-1 part of calcium carbonate, 0.01-0.1 part of vitamin C, 0.001-0.003 part of calcium hydrophosphate dihydrate, 5-20 parts of pseudo-ginseng, 3-15 parts of lotus leaf, 5-15 parts of rhizoma cyperi, 2-10 parts of pepper, 5-15 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 5-20 parts of angelica sinensis, 10-20 parts of rhizoma cimicifugae, 10-25 parts of burmannia, 10-25 parts of prepared rehmannia root and 5-15 parts of schizonepeta.
2. The oral care dentifrice of claim 1, comprising the following raw materials in parts by weight: 0.6-0.9 part of calcium carbonate, 0.04-0.08 part of vitamin C, 0.001-0.002 part of calcium hydrophosphate dihydrate, 10-15 parts of pseudo-ginseng, 5-13 parts of lotus leaf, 8-13 parts of rhizoma cyperi, 4-8 parts of pepper, 8-13 parts of radix angelicae, 12-18 parts of ligusticum wallichii, 10-18 parts of angelica sinensis, 12-18 parts of rhizoma cimicifugae, 12-20 parts of burmannia, 15-20 parts of prepared rehmannia root and 8-13 parts of schizonepeta.
3. The oral care dentifrice of claim 2, comprising the following raw materials in parts by weight: 0.8 part of calcium carbonate, 0.06 part of vitamin C, 0.002 part of calcium hydrogen phosphate dihydrate, 13 parts of pseudo-ginseng, 9 parts of lotus leaf, 10 parts of rhizoma cyperi, 6 parts of pepper, 10 parts of radix angelicae, 15 parts of ligusticum wallichii, 15 parts of angelica sinensis, 15 parts of rhizoma cimicifugae, 18 parts of burmannia, 18 parts of prepared rehmannia root and 10 parts of schizonepeta.
4. The oral care dentifrice of claim 1, further comprising the following raw materials in parts by weight: 5-15 parts of bitter bamboo juice, 1-10 parts of calanolia chinensis tear and 5-10 parts of alum.
5. The oral care dentifrice of claim 4, comprising the following raw materials in parts by weight: 0.8 part of calcium carbonate, 0.06 part of vitamin C, 0.002 part of calcium hydrophosphate dihydrate, 13 parts of pseudo-ginseng, 9 parts of lotus leaf, 10 parts of rhizoma cyperi, 6 parts of pepper, 10 parts of angelica dahurica, 15 parts of ligusticum wallichii, 15 parts of angelica, 15 parts of rhizoma cimicifugae, 18 parts of burley eggplant, 18 parts of prepared rehmannia root, 10 parts of schizonepeta, 10 parts of bitter bamboo juice, 6 parts of calabash tear and 8 parts of alum.
6. The oral care dentifrice of claim 1 further comprising 0.002 to 0.004 parts by weight of an essence.
7. The method of preparing an oral care dentifrice of any one of claims 1 to 6, comprising the steps of:
drying the raw materials except the calcium carbonate, the vitamin C and the calcium hydrophosphate dihydrate, and mixing to obtain a mixture;
crushing the mixture and grinding into powder;
adding calcium carbonate, vitamin C and calcium hydrogen phosphate dihydrate into the powder, and uniformly mixing to obtain the oral care dentifrice finished product.
8. The method of claim 7, wherein the oven drying temperature is 55-65 ℃.
9. The method of claim 7, wherein the powder is of size 300-350 mesh.
10. Use of an oral care dentifrice as claimed in any one of claims 1 to 6 in the manufacture of a medicament for the treatment of gum disease.
CN202210213030.5A 2022-03-05 2022-03-05 Oral care tooth powder and preparation method and application thereof Withdrawn CN114557942A (en)

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Application publication date: 20220531