CN105168058A - Traditional-Chinese-medicine-charcoal-containing primary-black fashionable toothpaste - Google Patents
Traditional-Chinese-medicine-charcoal-containing primary-black fashionable toothpaste Download PDFInfo
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- CN105168058A CN105168058A CN201510615233.7A CN201510615233A CN105168058A CN 105168058 A CN105168058 A CN 105168058A CN 201510615233 A CN201510615233 A CN 201510615233A CN 105168058 A CN105168058 A CN 105168058A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses traditional-Chinese-medicine-charcoal primary-black fashionable toothpaste. The traditional-Chinese-medicine-charcoal primary-black fashionable toothpaste is prepared from, by weight, 0.05% to 4% of crinis trachycarpi, 0.05% to 4% of herba cirsii carbonisatus, 0.05% to 4% of hos sophorae carbonisatus, 15% to 50% of abrasives, 20% to 60% of humectants, 1.0% to 2.0% of thickening agents, 0.1% to 1.0% of PVM/MA copolymers, 2% to 3% of surfactants, 0.3% to 0.5% of sweetening agents, 0.1% to 0.5% of preservatives, 1.0% to 2.0% of essence and the balance deionized water. The traditional-Chinese-medicine-charcoal primary-black fashionable toothpaste has the functions of cleaning the oral cavity, stopping bleeding and invigorating gums. According to the traditional-Chinese-medicine-charcoal primary-black fashionable toothpaste, traditional Chinese medicine culture serves as a carrier, pigment-free adding and completely-natural primary black serve as fashionable elements, the functional toothpaste is prepared based on the traditional Chinese medicine culture, the natural primary black serves as the fashionable element, and the personalized and functionalized toothpaste adapting to the modern fashion trend is created and can certainly have broad market prospects.
Description
Technical field
The present invention relates to a kind of toothpaste, is a kind of black fashion toothpaste of Chinese medicine charcoal body containing Petiolus Trachycarpi, Herba Cirsii, Flos Sophorae specifically, has the strong gum effect of hemostasis, belongs to oral cavity cleaning and nursing field.
Background technology
Toothpaste is the first-selection of people's common oral cleaning-nursing, is mainly used to cleaning oral cavity, fresh breath, tooth-whitening or prophylaxis of teeth disease.Along with the raising of health of people consciousness, propose requirements at the higher level to oral cavity cleaning and nursing product, consumer not only pays close attention to the cleaning function to tooth when choosing toothpaste, also pay close attention to the health care to oral cavity, even pays close attention to the fashionable element of product.
Body black bamboo charcoal toothpaste has been a kind of fashion abroad, but more rare at home, and body black bamboo charcoal toothpaste has effect of adsorption orifice cavity foreign flavor and tooth-whitening, is more and more subject to the favor of fashional consumption person.But, body black tooth cream containing Chinese medicine charcoal does not also occur at home, Chinese medicine charcoal is applied in formulation of tooth-paste by the present invention first, gives the health care of the natural black fashion appeal of body of toothpaste and the strong gum of hemostasis, has certain novelty, practicality and novelty.
Gingival hemorrhage is the common disease in oral cavity, be the spontaneous or minimal irritation of gingiva cause hemorrhage on a small quantity.Dental plaque and dental calculus can stimulate gingiva tissue, and cause blood capillary in tissue to stimulate resistance to decline to external world, vascular permeability increases; easily cause gingival hemorrhage; if do not take effective protective measure, gingivitis, periodontitis may be developed into, have a strong impact on the quality of life of patient.Use the toothpaste with hemostatic function not only can remove dental plaque and dental calculus, early stage gingival hemorrhage and inflammation can also be made to be repaired.
The mechanism of action of hemorrhage mainly comprises: one, promote blood coagulation and fibrinolysis; Two, keep the normal resistance of blood capillary, reduce vascular permeability; Three, vascular contractile response is promoted.Experiment proves, many Chinese medicine charcoals can shorten blood coagulation and bleeding time.All calcic in most plant, major part exists with the form of calcium oxalate crystals, some drugs is at high temperature conducive to the free of calcium, thus discharge soluble calcium, because calcium ion can promote blood coagulation, therefore, after Chinese medicine parch to black, soluble calcium just likely shortens clotting time, plays anastalsis.In addition, can generate the active carbon of some after Chinese medicine parch to black, active carbon has absorption, astriction, also can promote hemostasis.For some Chinese medicine, after parch to black, some property of medicine strengthens certain material base, and as the increase of solubility calcium, the increase of content of tannin can improve haemostatic effect.
Along with the development of modernization of Chinese medicine analytical technology, also achieve good development to the research of active ingredient of Chinese herbs, this prevents oral disease to provide good theoretical foundation and technical support for oral care product utilizes active ingredient of Chinese herbs to assist.Chinese medicinal toothpaste kind is in the market a lot, Chinese medicine charcoal hemostatic mechanism is applied to oral cavity cleaning and nursing field and does not also occur.
Summary of the invention
The characteristic that after the object of the invention is to utilize some Chinese medicine parch to black, the property of medicine strengthens, in conjunction with the hemostasis principle of hemorrhage and the hemostasis feature of three taste medicine charcoals, charred Petiolus Trachycarpi, field thistle charcoal and charred Flos Sophorae are ground to form micropowder to be made an addition in toothpaste, provides a kind of black fashion toothpaste of body integrating cleaning oral cavity, the strong gum of hemostasis.
The object of the present invention is achieved like this:
Containing the black fashion toothpaste of body of Chinese medicine charcoal, comprising percentage by weight is the active component of 0.5% ~ 10% and the matrix components of 90% ~ 99.5%, and described active component comprises charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae; Described matrix components comprises abrasive, wetting agent, thickening agent, Gantrez AN-119, surfactant, sweeting agent, antiseptic, essence and deionized water.
Toothpaste of the present invention, by weight percentage, the raw material components that described active component comprises: the charred Petiolus Trachycarpi of 0.05% ~ 4%, the field thistle charcoal of 0.05% ~ 4%, the charred Flos Sophorae of 0.05% ~ 4%;
The raw material components that described matrix components comprises: the abrasive of 15% ~ 50%, the wetting agent of 20% ~ 60%, the thickening agent of 1.0% ~ 2.0%, the Gantrez AN-119 of 0.1% ~ 1.0%, the surfactant of 2% ~ 3%, the sweeting agent of 0.3% ~ 0.5%, the antiseptic of 0.1% ~ 0.5%, the essence of 1.0% ~ 2.0%, deionized water is added into 100%.
Described charred Petiolus Trachycarpi is that then grind to form 800 ~ 1000 object micropowders, main active is tannin, and preferred addition is 0.1% ~ 2% by " Chinese Pharmacopoeia " 2010 editions annex correlation technique calcine.
Described field thistle charcoal is by the parch of " Chinese Pharmacopoeia " 2010 editions annex correlation techniques, and then grind to form 800 ~ 1000 object micropowders, main active is caffeic acid and chlorogenic acid, and preferred addition is 0.2% ~ 3%.
Described charred Flos Sophorae, by the parch of " Chinese Pharmacopoeia " 2010 editions annex correlation techniques, then grinds to form 800 ~ 1000 object micropowders, and main active is globulariacitrin and glycoside unit Quercetin thereof, and preferred addition is 0.2% ~ 3%.
Described abrasive is one or both mixture in calcium carbonate, calcium hydrogen phosphate, silicon dioxide.
Described wetting agent is one or more mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol.
Described thickening agent is one or more mixture in sodium carboxymethyl cellulose, xanthan gum, guar gum, carrageenan.
Described Gantrez AN-119 can improve active matter residence time in the oral cavity, improves the bioavailability of active matter.
Described surfactant is one or more mixture in sodium laurylsulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl betanin.
Described sweeting agent is one or both the multiple mixture in saccharin sodium, acesulfame potassium.
Described antiseptic is one or more mixture in sodium benzoate, methyl hydroxybenzoate, propyl hydroxybenzoate.
Other additive can also be comprised, as tetrasodium pyrophosphate, fluoride etc. in above-mentioned toothpaste.
The present invention first by charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae three taste Chinese medicine charcoal composite usage in toothpaste, both the styptic activity of single Chinese medicine charcoal had been played, make again the haemostatic effect of three taste Chinese medicine charcoals and stop blooding principle combination, Synergistic, play haemostatic effect better, with the addition of Gantrez AN-119 simultaneously, the adhesive attraction that can produce by high molecular polymer and oral mucosa, makes the active component adhered on oral mucosa play a role lastingly, improves the bioavailability of active matter.
The present invention specifically utilizes the tannin in charred Petiolus Trachycarpi and the protein bound in blood to form macromolecular substances, forms caking, promote blood coagulation, and can shrink blood capillary, reach anastaltic effect at vascular injury place; Utilize the caffeic acid in field thistle charcoal and chlorogenic acid, by making local vasoconstriction, suppressing fibrinolytic, shortening blood coagulation and bleeding time reach haemostatic effect; Utilize globulariacitrin in charred Flos Sophorae and glycoside unit Quercetin thereof, keep the normal resistance of blood capillary, reduce vascular permeability, repair because fragility increases that hemorrhage blood capillary recovers normal elasticity.Three taste Chinese medicine charcoals have the effect for the treatment of both the principal and secondary aspects of a disease to gingival hemorrhage, the fragility of repairing gingiva blood capillary is valued in hemostasis repair process, increase the normal elasticity of blood capillary, strengthen the resistivity that blood capillary stimulates to external world, thus reach the strong gum effect of hemostasis.
The black fashion toothpaste of Chinese medicine charcoal body of the present invention, the Chinese medicine carbon activity composition added in the oral cavity residual after can being brushed teeth by process neutralization of brushing teeth, directly by impaired hemorrhage capillary absorbance, and normal oral mucosa and sublingual vein absorb and enter blood circulation, avoid the Degradation because of gastrointestinal enzyme and acid, and the head of liver crosses elimination effect to the destruction of active component, improve the degree of absorbing of Chinese medicine carbon activity composition, play the effect of the strong gum of hemostasis faster and better.
Detailed description of the invention
Below the statement to several Chinese medicine charcoal hemostatic mechanisms that the present invention relates to:
Charred Petiolus Trachycarpi is the sheath fiber with babassu Petiolus Trachycarpi, removes fibrous palm fiber, dries, cut into pieces, through the black gray expandable carbon shape Chinese medicine of calcine.Charred Petiolus Trachycarpi, containing tannin, has hemostasis and astriction, and can shrink blood capillary.Its characteristic is that the protein bound of tannin easily and in blood forms macromolecular substances, and form caking at vascular injury place, stop blood outflow, reaching hemostasis object, is the conventional charcoal drug of tcm clinical practice being treated hemorrhagic disease.
Field thistle charcoal is with the herb of Herba Cirsii and the subterraneous stem carbon shape Chinese medicine through calcine.Herba Cirsii is herb and the subterraneous stem of Compositae herbaceos perennial field thistle, is traditional Hemostatic of traditional herb medicine.Containing flavonoid glycoside composition (as linarin, rutin) and organic acid composition (as protocatechuic acid, caffeic acid, chlorogenic acid) in Herba Cirsii.Flavonoid glycoside composition has anastalsis, and caffeic acid and chlorogenic acid are also the effective ingredient of Herba Cirsii hemostasis, has and shortens blood coagulation and the effect in bleeding time.Herba Cirsii hemostasis, mainly through making local vasoconstriction, suppresses fibrinolytic and plays a role.Hardly containing flavones ingredient in field thistle charcoal, but more containing compositions such as caffeic acid, chlorogenic acid, former catechu, Herba Cirsii has and significantly promotes Blood coagulation, and hemostasis effective ingredient is chlorogenic acid and caffeic acid.According to the literature, some is contained to the medical material of rutin constituents, raise with temperature in parch to black process, Folium Symplocoris Caudatae glycoside is converted into the composition of chlorogenic acid, Caffeic acids after heated.Caffeic acid in Herba Cirsii after parch to black, chlorogenic acid content higher than the content in Herba Cirsii section, and in Herba Cirsii section rutin content apparently higher than field thistle charcoal.Hardly containing flavones ingredient in field thistle charcoal, but more containing compositions such as caffeic acid, chlorogenic acid, former catechu, so haemostatic effect is better.
Charred Flos Sophorae is that the dry flower and alabastrum of leguminous plant Chinese scholartree is through frying the Chinese medicine to carbon shape.It is stronger that Flos Sophorae fries haemostatic effect to carbon shape.Flos Sophorae has cooling blood for hemostasis, effect of purging liver-fire.Main containing globulariacitrin or its compound in Flos Sophorae, globulariacitrin and glycoside unit Quercetin thereof can keep the normal resistance of blood capillary, reduce vascular permeability, can make because fragility increases that hemorrhage blood capillary recovers normal elasticity.
Set forth the present invention further, but the use of these embodiments only for being described in more detail below by specific embodiment in conjunction with effect test example content, and shall not be applied to and limit the present invention in any form.
embodiment 1
Containing the black fashion toothpaste of body of Chinese medicine charcoal, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) methyl hydroxybenzoate, propyl hydroxybenzoate, essence are added stirring and dissolving in container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of PEG-4000 pre-dispersed evenly after add remaining PEG-4000 again;
3) deionized water to be added in premix pot in 1, then add saccharin sodium, acesulfame potassium, sodium lauroyl sarcosine, and stirring and dissolving, then the raw material in container B is added in premix pot 1 stir;
4) sorbitol is added in premix pot 2;
5) calcium carbonate, silicon dioxide, sodium carboxymethyl cellulose, guar gum, sodium laurylsulfate, charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae are added mix homogeneously in meal mixer;
6) liquid material in premix pot 1 and premix pot 2 is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 2
Containing the black fashion toothpaste of body of Chinese medicine charcoal, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) essence, methyl hydroxybenzoate are added stirring and dissolving in container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of propylene glycol pre-dispersed evenly after add remaining propylene glycol again;
3) deionized water to be added in premix pot in 1, then add saccharin sodium, tetrasodium pyrophosphate, sodium lauroyl glutamate, sodium benzoate, and stirring and dissolving, then the raw material in container B is added in premix pot 1 stir;
4) glycerol, sorbitol are added in premix pot 2;
5) calcium hydrogen phosphate, silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate, charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae are added mix homogeneously in meal mixer;
6) liquid material in premix pot 1 and premix pot 2 is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 3
Containing the black fashion toothpaste of body of Chinese medicine charcoal, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) container A is added after being weighed by essence;
2) Gantrez AN-119 is added in container B, with a small amount of Polyethylene Glycol-600 pre-dispersed evenly after add remaining Polyethylene Glycol-600 again;
3) deionized water to be added in premix pot in 1, then add saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, cocoyl betanin, sodium fluoride, and stirring and dissolving, then the raw material in container B is added in premix pot 1 stir;
4) sorbitol is added in premix pot 2;
5) silicon dioxide, sodium carboxymethyl cellulose, carrageenan, sodium laurylsulfate, charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae are added mix homogeneously in meal mixer;
6) liquid material in premix pot 1 and premix pot 2 is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 4
Containing the black fashion toothpaste of body of Chinese medicine charcoal, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) essence, methyl hydroxybenzoate are added container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of Polyethylene Glycol-600 pre-dispersed evenly after add remaining Polyethylene Glycol-600 again;
3) deionized water to be added in premix pot in 1, then add saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, and stirring and dissolving, then the raw material in container B is added in premix pot 1 stir;
4) sorbitol is added in premix pot 2;
5) silicon dioxide, sodium carboxymethyl cellulose, carrageenan, sodium laurylsulfate, charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae are added mix homogeneously in meal mixer;
6) liquid material in premix pot 1 and premix pot 2 is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
clinical trial part:
Experiment 1: the impact of hemorrhage method time that mice is docked:
Get NIH inbred mice 30, body weight 18 ~ 22g, male and female half and half, be divided into 3 groups at random, be respectively high dose group A, low dose group B, blank group (not containing Chinese medicine charcoal) C.Tested the previous day loses hair or feathers with 8% barium sulfate, dermal application to sample toothpaste, every day 2 times, continuous 6 days, last after 1 hour, cuts off Mouse Tail-tip to toothpaste test sample, treats that blood flows out and starts timing, suck blood to depletion of blood flows out with filter paper, be the bleeding time, result is as shown in table 1 below.
Table 1 is on the impact of mice docking method clotting time
| Group | Mice quantity (only) | Dosage (g/kg) | Bleeding time (second) |
| High dose group A | 10 | 5 | 1.58±0.73 |
| Low dose group B | 10 | 2 | 1.91±0.43 |
| Blank group C | 10 | 3 | 3.80±1.64 |
The experimental result of above table 1 shows, sample toothpaste group and blank group have significant difference to mice method bleeding time of docking on statistical significance, illustrate that sample toothpaste has the effect shortening the mice bleeding time.
Experiment 2: the efficacy validation on Clinical practice:
Choose the artificial subjects that 60 are suffered from gingival hemorrhage, be divided into test group A and matched group B at random, experimental group A uses embodiment toothpaste, matched group B uses certain well-known hemostasis brand toothpaste, adopting sooner or later to use for each person every day specifies test toothpaste to brush teeth once, and a 1.5 ~ 2g, after using 30 days continuously, reduce situation to gingival hemorrhage index to add up, result is as shown in table 2 below.
The efficacy validation of table 2 on Clinical practice
| Group | Number | Effective | Effectively | Invalid | Effective percentage (%) |
| Test group A | 30 | 13 | 16 | 1 | 96.7％ |
| Matched group B | 30 | 10 | 16 | 4 | 86.7％ |
The statistical description of the Clinical practice effect table 2 of above toothpaste, the present embodiment toothpaste has good effect to suppression gingival hemorrhage, is better than the competing product toothpaste in market, reaches desired design object in fast effectively.
In sum, the invention is intended to take Culture of TCM as carrier, pigment is added with nothing, 100% natural body is black is fashionable element, functional toothpaste is made with Culture of TCM, do fashionable element with natural body is black, create cater to modern trend trend personalization, functionalization toothpaste, wide market prospect will be had.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore everyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (9)
1., containing the black fashion toothpaste of body of Chinese medicine charcoal, comprise the active component of 0.5% ~ 10% and the matrix components of 90% ~ 99.5%, it is characterized in that: described active component comprises charred Petiolus Trachycarpi, field thistle charcoal, charred Flos Sophorae; Described matrix components comprises abrasive, wetting agent, thickening agent, Gantrez AN-119, surfactant, sweeting agent, antiseptic, essence and deionized water.
2. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 1, is characterized in that: the raw material components that described active component comprises: the charred Petiolus Trachycarpi of 0.05% ~ 4%, the field thistle charcoal of 0.05% ~ 4%, the charred Flos Sophorae of 0.05% ~ 4%;
The raw material components that described matrix components comprises: the abrasive of 15% ~ 50%, the wetting agent of 20% ~ 60%, the thickening agent of 1.0% ~ 2.0%, the Gantrez AN-119 of 0.1% ~ 1.0%, the surfactant of 2% ~ 3%, the sweeting agent of 0.3% ~ 0.5%, the antiseptic of 0.1% ~ 0.5%, the essence of 1.0% ~ 2.0%, deionized water is added into 100%.
3. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 2, it is characterized in that: described charred Petiolus Trachycarpi is by " Chinese Pharmacopoeia " 2010 editions annex correlation technique calcine, then grind to form 800 ~ 1000 object micropowders, preferred addition is 0.1% ~ 2%.
4. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 2, is characterized in that: described field thistle charcoal is by the parch of " Chinese Pharmacopoeia " 2010 editions annex correlation techniques, and then grind to form 800 ~ 1000 object micropowders, preferred addition is 0.2% ~ 3%.
5. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 2, is characterized in that: described charred Flos Sophorae is by the parch of " Chinese Pharmacopoeia " 2010 editions annex correlation techniques, and then grind to form 800 ~ 1000 object micropowders, preferred addition is 0.2% ~ 3%.
6. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 2, is characterized in that:
Described abrasive is one or both mixture in calcium carbonate, calcium hydrogen phosphate, silicon dioxide;
Described wetting agent is one or more mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol;
Described thickening agent is one or more mixture in sodium carboxymethyl cellulose, xanthan gum, guar gum, carrageenan;
Described surfactant is one or more mixture in sodium laurylsulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl betanin.
7. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 2, is characterized in that: described Gantrez AN-119 can improve active matter residence time in the oral cavity, improves the bioavailability of active matter.
8. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 2, is characterized in that: described sweeting agent is one or both the multiple mixture in saccharin sodium, acesulfame potassium; Described antiseptic is one or more mixture in sodium benzoate, methyl hydroxybenzoate, propyl hydroxybenzoate.
9. the black fashion toothpaste of body containing Chinese medicine charcoal according to claim 1, is characterized in that: can also comprise other additive in above-mentioned toothpaste, as tetrasodium pyrophosphate, fluoride etc.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106214598A (en) * | 2016-07-31 | 2016-12-14 | 申秋英 | Aminoacid toothpaste |
| CN113230168A (en) * | 2021-05-11 | 2021-08-10 | 广州市盛龙口腔清洁用品有限公司 | Antibacterial deodorizing fragrant toothpaste containing natural plant extract |
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| CN1169862A (en) * | 1996-07-04 | 1998-01-14 | 陈继忠 | Chinese medicine preparation for stomatocace |
| JP2000143471A (en) * | 1998-11-13 | 2000-05-23 | Chikutan Circle Kk | Toothpaste composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106214598A (en) * | 2016-07-31 | 2016-12-14 | 申秋英 | Aminoacid toothpaste |
| CN113230168A (en) * | 2021-05-11 | 2021-08-10 | 广州市盛龙口腔清洁用品有限公司 | Antibacterial deodorizing fragrant toothpaste containing natural plant extract |
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| CN105168058B (en) | 2017-12-26 |
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Effective date of registration: 20221102 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Lianxia Town, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |
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