CN113975359A - Pharmaceutical composition and preparation method and application thereof - Google Patents
Pharmaceutical composition and preparation method and application thereof Download PDFInfo
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- CN113975359A CN113975359A CN202111098718.5A CN202111098718A CN113975359A CN 113975359 A CN113975359 A CN 113975359A CN 202111098718 A CN202111098718 A CN 202111098718A CN 113975359 A CN113975359 A CN 113975359A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a pharmaceutical composition, a preparation method and application thereof. The pharmaceutical composition consists of the following raw material medicines in the weight range: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of phellodendron bark, 4-8 g of plantain seed, 3-7 g of angelica, 2-6 g of combined spicebush root, 1-4 g of sharpleaf galangal fruit and 1-5 g of grassleaf sweelflag rhizome. The pharmaceutical composition can treat patients with chyluria, and can effectively relieve or eliminate turbid urine symptoms of the patients with chyluria.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition, a preparation method thereof and application thereof in treating chyluria or lymphatic leakage.
Background
Chyluria (chyluria) is caused by lymphangioleiomyomatosis, chyluria liquid enters urine in a countercurrent way to form chyluria, the appearance is milk white in different degrees, and the chyluria test can be positive. If it contains much blood, it is called chyluria. Chyluria is characterized by turbid urine like milk, swill and soybean milk, so it is named. The onset age of chyluria is 30-60 years old. The pathogenesis of chyluria is currently considered to be the obstruction of a chest catheter, the damage of local lymphangitis, the change of lymph dynamics, the entry of lymph into a urinary tract and the occurrence of chyluria. Chyluria is classified into mild, moderate and severe according to severity. Mild manifestations are intermittent chyluria, no chylomicron clot formation, and no weight loss.
Lymphatic leakage is usually caused by operation-related injury, the lymphatic circulation is damaged or interrupted, the lymph pressure at the damaged part is greater than the pressure in tissues or the pressure in body cavities, and the lymph fluid flows out to form the lymphatic leakage.
At present, western medicines have poor effects on treating chyluria and lymphatic leakage and have more side effects. Therefore, a traditional Chinese medicine formula for treating chyluria and lymphatic leakage is urgently needed to be provided.
Disclosure of Invention
According to the research and clinical test and verification of the traditional Chinese medicine theory, the invention provides the pharmaceutical composition capable of effectively treating chyluria and lymphatic leakage.
The invention aims to provide a pharmaceutical composition for treating chyluria or lymphatic leakage.
The invention provides a pharmaceutical composition, which consists of the following raw material medicines in the weight range: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of phellodendron bark, 4-8 g of plantain seed, 3-7 g of angelica, 2-6 g of combined spicebush root, 1-4 g of sharpleaf galangal fruit and 1-5 g of grassleaf sweelflag rhizome.
Further, the pharmaceutical composition is composed of the following raw material medicines in the weight range: 5-9 g of glutinous rice root, 5-9 g of yam rhizome, 3-5 g of phellodendron bark, 5-7 g of plantain seed, 4-6 g of angelica, 3-5 g of combined spicebush root, 2-3 g of sharpleaf galangal fruit and 2-4 g of grassleaf sweelflag rhizome.
Further, the pharmaceutical composition is composed of the following raw material medicines in the weight range: 6 g of glutinous rice root, 6 g of yam rhizome, 4 g of phellodendron bark, 6 g of plantain seed, 5 g of angelica, 4 g of combined spicebush root, 2 g of sharpleaf galangal fruit and 3 g of grassleaf sweelflag rhizome.
Another object of the present invention is to provide a process for the preparation of a pharmaceutical composition.
The invention provides a preparation method of a pharmaceutical composition, which comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron bark, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 4-6 times of water, decocting for 1.5-2 hours, and filtering to obtain a liquid medicine.
Another object of the present invention is to provide a pharmaceutical preparation formed using the above pharmaceutical composition.
Further, the pharmaceutical preparation is selected from one of powder, granules, tablets, capsules, solutions and suspensions.
Another object of the present invention is to provide a use of a pharmaceutical composition for the preparation of a medicament for the treatment of chyluria or postoperative lymphatic leakage.
The invention provides an application of a pharmaceutical composition in treating chyluria or postoperative lymphatic leakage.
Further, the pharmaceutical composition is administered twice daily, wherein the single administration dose is the pharmaceutical composition and the dose thereof as described above.
The glutinous rice root of the invention has sweet taste; the nature is flat; entering liver meridian; can be used for treating fever due to yin deficiency, spontaneous perspiration, night sweat, thirst, dry throat, hepatitis, and filariasis; has the effects of nourishing yin, removing heat, and relieving sweating.
The yam rhizome of the invention is bitter in taste and mild in nature. It enters liver, stomach and bladder meridians. Has effects of promoting diuresis, treating stranguria, and dispelling pathogenic wind and dampness. It is used clinically for treating chylous stranguria, leucorrhea, etc. Bi Xie is the essential herb for treating stranguria with chyluria and turbid urine due to damp-turbidity stagnation in the lower energizer, because it can induce diuresis and excrete turbid; for leukorrhagia due to dampness, it is combined with Fu Ling and Bai Zhu.
The golden cypress is bitter and cold in nature; entering kidney, bladder and large intestine meridians; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, and removing toxic materials; can be used for treating dysentery due to damp-heat pathogen, jaundice, leukorrhagia, stranguria caused by heat pathogen, tinea pedis, flaccidity, bone steaming, overstrain, night sweat, nocturnal emission, pyocutaneous disease, toxic swelling, eczema, and pruritus.
The plantain seeds are sweet in taste and slightly cold in nature; it enters liver, kidney, lung and small intestine meridians; has effects in clearing away heat, promoting urination, eliminating dampness, treating stranguria, improving eyesight, and eliminating phlegm; can be used for treating edema, heat stranguria, pain, summer-heat dampness diarrhea, conjunctival congestion, swelling and pain, phlegm heat cough.
The Chinese angelica is warm in nature, sweet and pungent; it enters liver, heart and spleen meridians; has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease.
The combined spicebush root of the invention has pungent taste and warm property; entering lung, spleen, kidney and bladder meridians; has effects in promoting qi circulation, relieving pain, warming kidney, and dispelling cold; can be used for treating abdominal distention and pain, asthma, bladder deficiency cold, enuresis, frequent micturition, hernia, and dysmenorrhea.
The fructus alpiniae oxyphyllae of the invention is warm in nature and pungent in taste; entering spleen and kidney meridians; has effects in warming spleen, relieving diarrhea, arresting salivation, warming kidney, stopping nocturnal emission, and arresting polyuria; can be used for treating diarrhea due to spleen cold, abdominal psychroalgia, excessive saliva, enuresis due to kidney deficiency, frequent micturition, and nocturnal emission.
The grassleaf sweelflag rhizome of the invention is pungent in flavor and warm in nature; heart and stomach meridians entered; has effects in eliminating dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence; can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness.
The invention has the beneficial effects that:
the traditional Chinese medicines such as the glutinous rice root, the yam rhizome, the phellodendron bark, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit, the grassleaf sweelflag rhizome and the like are selected, and the traditional Chinese medicines are combined to generate a synergistic effect, so that chyluria and lymphatic leakage can be effectively treated. The medicinal composition takes the glutinous rice root and the yam rhizome as main components, reduces turbid urine, and is added with the golden cypress, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome for use together with the glutinous rice root and the yam rhizome, so that the medicinal composition has excellent treatment effects on chyluria and lymphatic leakage.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The embodiment of the invention provides a pharmaceutical composition, and a preparation method and application thereof. The details are described below. It should be noted that the following description of the embodiments is not intended to limit the preferred order of the embodiments. In addition, in the description of the present invention, the term "including" means "including but not limited to". Various embodiments of the invention may exist in a range of forms; it is to be understood that the description in the form of a range is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention; accordingly, the description of the ranges should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within the ranges. For example, it is contemplated that the description of a range from 1 to 6 has specifically disclosed sub-ranges such as, for example, from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as individual numbers within a range such as, for example, 1, 2, 3, 4, 5, and 6, as applicable regardless of the range. In addition, whenever a numerical range is indicated herein, it is meant to include any number (fractional or integer) recited within the indicated range.
The embodiment of the invention provides a pharmaceutical composition which can be used for treating chyluria or lymphatic leakage. The pharmaceutical composition consists of the following raw material medicines in the weight range: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of phellodendron bark, 4-8 g of plantain seed, 3-7 g of angelica, 2-6 g of combined spicebush root, 1-4 g of sharpleaf galangal fruit and 1-5 g of grassleaf sweelflag rhizome.
Further, in the pharmaceutical composition, the glutinous rice root may weigh 4 g, 5 g, 6 g, 7 g, 8 g, 9 g, or 10 g; the weight of the yam rhizome can be 4 g, 5 g, 6 g, 7 g, 8 g, 9 g or 10 g; the weight of the phellodendron amurense can be 2 g, 3 g, 4 g, 5 g or 6 g; the weight of the plantain seeds can be 4 g, 5 g, 6 g, 7 g and 8 g; the weight of the angelica can be 3 g, 4 g, 5 g, 6 g or 7 g; the weight of the combined spicebush root can be 2 g, 3 g, 4 g, 5 g or 6 g; the weight of the fructus alpiniae oxyphyllae can be 1 gram, 2 grams, 3 grams or 4 grams; the weight of the grassleaf sweelflag rhizome can be 1 g, 2 g, 3 g, 4 g or 5 g.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron bark, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 4-6 times of water, decocting for 1.5-2 hours, and filtering to obtain a liquid medicine.
The pharmaceutical composition can be used for forming various pharmaceutical preparations; further, the pharmaceutical formulation may be one of powder, granule, tablet, capsule, solution and suspension. In practical application, the pharmaceutical composition can be prepared into a certain dosage form suitable for use according to specific needs.
The pharmaceutical composition can be applied to the medicines for treating chyluria or postoperative lymphatic leakage. Further, the pharmaceutical composition is administered twice daily, wherein the single administration dose is the pharmaceutical composition and the dose thereof as described above. That is, the pharmaceutical composition is administered in a single dose of: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of phellodendron bark, 4-8 g of plantain seed, 3-7 g of angelica, 2-6 g of combined spicebush root, 1-4 g of sharpleaf galangal fruit and 1-5 g of grassleaf sweelflag rhizome.
The invention is described in further detail with reference to a part of the test results, which are described in detail below with reference to specific examples.
Example 1
The embodiment provides a pharmaceutical composition, which consists of the following raw material medicines in the weight range: 10 g of glutinous rice root, 4 g of yam rhizome, 6 g of phellodendron bark, 4 g of plantain seed, 7 g of angelica, 2 g of combined spicebush root, 4 g of sharpleaf galangal fruit and 1 g of grassleaf sweetflag rhizome.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 6 times of water, decocting for 2 hours, and filtering to obtain liquid medicine.
Example 2
The embodiment provides a pharmaceutical composition, which consists of the following raw material medicines in the weight range: 4 g of glutinous rice root, 10 g of yam rhizome, 2 g of phellodendron bark, 8 g of plantain seed, 3 g of angelica, 6 g of combined spicebush root, 1 g of sharpleaf galangal fruit and 5 g of grassleaf sweetflag rhizome.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 4 times of water, decocting for 1.5 hours, and filtering to obtain liquid medicine.
Example 3
The embodiment provides a pharmaceutical composition, which consists of the following raw material medicines in the weight range: glutinous rice root 9 g, yam rhizome 5 g, phellodendron bark 5 g, plantain seed 5 g, Chinese angelica root 6 g, lindera root 3 g, bitter cardamon 3 g, and acorus calamus 2 g.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 6 times of water, decocting for 1.5 hours, and filtering to obtain liquid medicine.
Example 4
The embodiment provides a pharmaceutical composition, which consists of the following raw material medicines in the weight range: 5 g of glutinous rice root, 9 g of yam rhizome, 3 g of phellodendron bark, 7 g of plantain seed, 4 g of angelica, 5 g of combined spicebush root, 2 g of sharpleaf galangal fruit and 4 g of grassleaf sweetflag rhizome.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 4 times of water, decocting for 2 hours, and filtering to obtain liquid medicine.
Example 5
The embodiment provides a pharmaceutical composition, which consists of the following raw material medicines in the weight range: 6 g of glutinous rice root, 6 g of yam rhizome, 4 g of phellodendron bark, 6 g of plantain seed, 5 g of angelica, 4 g of combined spicebush root, 2 g of sharpleaf galangal fruit and 3 g of grassleaf sweetflag rhizome.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 5 times of water, decocting for 2 hours, and filtering to obtain liquid medicine.
Test example 1
The test example used the pharmaceutical compositions of examples 1-5 to treat patients with chyluria, and the treatment results were recorded, and the results are detailed in table 1.
The treatment method comprises the following steps: the medicine liquid prepared by the medicine composition in the embodiment 1-5 is respectively used for treating 66 patients with chyluria, the medicine is taken twice a day, the treatment time is 28 days, and the effective patients are continuously observed for 6 months; wherein the dose in example 5 is a single administration dose.
The evaluation standard of curative effect is as follows: the effect is shown: the color of the urine turns clear after treatment, and no obvious relapse occurs within 6 months; improvement: the urine color turns clear obviously, and turbid urine occasionally occurs; and (4) invalidation: turbid urine has no obvious improvement.
The treatment results are as follows:
TABLE 1
According to the experimental examples, the total effective rate of 66 chyluria patients treated by the pharmaceutical composition of each embodiment of the invention is up to 96.97%, and the beneficial effect is remarkable. For example, treatment of chyluria patients with the pharmaceutical composition of example 5 resulted in: 26 cases of significant effect, the significant effect efficiency is 39.39%; improving 38 cases, wherein the improving efficiency is 57.58%; the ineffective efficiency is 3.03 percent in 2 cases. The total effective rate of the medicine composition reaches 96.97 percent.
In summary, the pharmaceutical composition of the present invention is capable of treating a patient with chyluria, which effectively alleviates or eliminates the symptoms of the patient with chyluria.
The pharmaceutical composition provided by the embodiments of the present invention, the preparation method and the application thereof are described in detail above, the principle and the embodiment of the present invention are illustrated herein by using specific examples, and the description of the above embodiments is only used to help understanding the method of the present invention and the core concept thereof; meanwhile, for those skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and as described above, the content of the present specification should not be construed as a limitation to the present invention.
Claims (8)
1. The pharmaceutical composition is characterized by comprising the following raw material medicines in the weight range: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of phellodendron bark, 4-8 g of plantain seed, 3-7 g of angelica, 2-6 g of combined spicebush root, 1-4 g of sharpleaf galangal fruit and 1-5 g of grassleaf sweelflag rhizome.
2. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is composed of the following raw materials by weight: 5-9 g of glutinous rice root, 5-9 g of yam rhizome, 3-5 g of phellodendron bark, 5-7 g of plantain seed, 4-6 g of angelica, 3-5 g of combined spicebush root, 2-3 g of sharpleaf galangal fruit and 2-4 g of grassleaf sweelflag rhizome.
3. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition is composed of the following raw materials by weight: 6 g of glutinous rice root, 6 g of yam rhizome, 4 g of phellodendron bark, 6 g of plantain seed, 5 g of angelica, 4 g of combined spicebush root, 2 g of sharpleaf galangal fruit and 3 g of grassleaf sweelflag rhizome.
4. A process for the preparation of a pharmaceutical composition according to any one of claims 1 to 3, comprising the steps of:
s1, preparing materials:
glutinous rice root: taking raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, performing primary stage, and drying;
rhizoma Dioscoreae Septemlobae: taking raw medicinal materials, removing fibrous roots, removing clean soil, slicing and drying in the sun;
phellodendron bark: removing impurities, spraying clear water, moistening, slicing or shredding, and drying in the sun;
plantain seed: removing impurities, screening out mud scraps and empty particles;
chinese angelica: removing impurities, cleaning, moistening, slightly drying to proper internal and external humidity, slicing, and sun drying;
combined spicebush root: removing fine root, cleaning, slicing, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
grassleaf sweelflag rhizome: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking the glutinous rice root, the yam rhizome, the phellodendron bark, the plantain seed, the angelica, the combined spicebush root, the sharpleaf galangal fruit and the grassleaf sweelflag rhizome according to the weight, adding 4-6 times of water, decocting for 1.5-2 hours, and filtering to obtain a liquid medicine.
5. A pharmaceutical formulation formed using the pharmaceutical composition of any one of claims 1 to 3.
6. The pharmaceutical formulation of claim 5, wherein the pharmaceutical formulation is selected from one of a powder, a granule, a tablet, a capsule, a solution, and a suspension.
7. Use of a pharmaceutical composition according to any one of claims 1 to 3 for the manufacture of a medicament for the treatment of chyluria or post-operative lymphatic leakage.
8. The use according to claim 7, wherein the pharmaceutical composition is administered twice daily, wherein the single dose is the pharmaceutical composition and the dose thereof according to any one of claims 1 to 3.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884722A (en) * | 2010-07-08 | 2010-11-17 | 张秀兰 | Medicament for treating chyluria and preparation method thereof |
| CN103432335A (en) * | 2013-08-30 | 2013-12-11 | 宋克垣 | Medicament for treating chyluria and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884722A (en) * | 2010-07-08 | 2010-11-17 | 张秀兰 | Medicament for treating chyluria and preparation method thereof |
| CN103432335A (en) * | 2013-08-30 | 2013-12-11 | 宋克垣 | Medicament for treating chyluria and preparation method thereof |
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| Title |
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| 唐爱莲等: "糯稻根颗粒剂制备及其游离氨基酸的鉴别与含量测定", 《中南药学》 * |
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