CN106902306A - A kind of Chinese medicine for treating kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction and preparation method thereof - Google Patents
A kind of Chinese medicine for treating kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction and preparation method thereof Download PDFInfo
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- CN106902306A CN106902306A CN201710149339.1A CN201710149339A CN106902306A CN 106902306 A CN106902306 A CN 106902306A CN 201710149339 A CN201710149339 A CN 201710149339A CN 106902306 A CN106902306 A CN 106902306A
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Abstract
The invention discloses a kind of Chinese medicine for treating kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction and preparation method thereof, described Chinese medicine includes following material medicine：The 30g of Semen Cuscutae 15, the 16g of Fructus Corni 14, the 16g of the fruit of Cherokee rose 14, the 30g of calcined Dragon's bone 20, the 20g of semen allii tuberosi 15, the 45g of the Radix Astragali 30, the 3.5g of amber 2.5, the boiling hot 5g of leech 3, the 20g of fructus alpiniae oxyphyllae 15, the 15g of mantis egg-case 10, the 30g of field pennycress 20, the 16g of radix cyathulae 14.The present invention is made of medicine in pure natural raw material, organic cooperation between various medicines, Synergistic, prepares reasonable, abundant raw material, method is simple, convenient to take, good effect, low cost is to treat the big innovation on benign prostate hyperplasia detrusor urinae of bladder dysfunction medicine.
Description
Technical field
The present invention relates to medicine, more particularly to one kind treats kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder
Chinese medicine of dysfunction and preparation method thereof.
Background technology
Benign prostate hyperplasia (benign prostatic hyperplasia, BPH) is middle-aging male common disease,
50-60 Sui clinical onset rate is 30-50%, and 60-70 Sui is 60%, is up to 83% within 80 years old, with the increase of China aged,
The patient can be more and more.BPH clinics are mainly shown as under frequent micturition, urgent urination, dysuria, enuresis nocturna frequency and retention of urine etc. urinates
Road symptom, with the passing of time may have influence on the function of kidney, cause renal insufficiency, have a strong impact on the quality of life of patient.
BPH physiology, pathological change are the hyperplasia of prostate of prostate, urethra not exclusively or is completely blocked, prostate-urethra
Portion's extension, urethral resistance increases, and compensatory is plump and convergent force strengthens to cause detrusor urinae of bladder to occur therefrom.Long-term
Urethral resistance high and detrusor compensatory shrink, and finally cause detrusor contractions decompensation, contractile function of detrusor muscles occur and are damaged
Change with bladder compliance.
Treatment BPH, clinical many prostates that hyperplasia is reduced using 5α-reductase inhibitor；Urine is alleviated in alpha receptor blocking agent
The spasm of road, bladder neck and prostate smooth musculature cells, reduces urethra pressure；Transurethral prostatic electroresection A cuts off the prostatitis of hyperplasia
Gland is treated.The drug therapy course for the treatment of is long, expensive, and side effect is big, and effect is satisfied with not to the utmost, most of to need operative treatment,
But about 10%-40% patient's postoperative curative effect is bad, the urination disorder of patient can not be released, what is had wants Preserving time urethral catheterization, very
To bladder stoma.Research both at home and abroad shows in addition to Detrusor overactivity, detrusor contractions are weak be BPH postoperative curative effect not
Good main cause, accounts for the 50% of all operations.Lack for benign prostate hyperplasia detrusor urinae of bladder dysfunction at present
Weary effective treatment method.
Hyperplasia of prostate belongs to the category of the traditional Chinese medical science " retention of urine ", and benign prostate hyperplasia contractile function of detrusor muscles obstacle is
The performance of " kidney qi deficiency, kidney loses and gasifies ", is the disease of " asthenia in origin and asthenia in superficiality ", and kidney loses and gasifies as disease originally, and stasis blocking water channel is the mark of disease.Kidney
Gasification refer to adjustment effect that kidney is metabolized to aqueous.Whether the gasification function of kidney is normally maintaining internal body fluid metabolism flat
Key effect is played in weighing apparatus, the generation excretion of especially urine depends on the rising gasification of kidney.Kidney is belonged to bladder by the network of channels and collaterals
Relation in table is constituted, the main gasification of kidney, bladder storage are urinated, and the two physiologically completes the gasification to body fluid and Excretion jointly.Such as open
Close imbalance, then the paruria symptom for occurring.Benign prostatic hyperplasia patientss are over fifty, and kidney qi is certainly empty；Prostate solid tissue
Hyperplasia be attributable to " Disorder product " category, category stasis blocking for suffer from.Kidney loses gasification, and folding is unfavorable, in addition water channel " Disorder products " stasis blocking, it is excessive
Aqueous can not be excreted in time, stop foring the disease of asthenia in origin and asthenia in superficiality for water is wet.Kidney asthenia as the principal aspect, stasis blocking for mark, sample each other because
Really, vicious circle is formed, and causes kidney qi more empty, alluvial is more weighed, water channel impatency is caused eventually, form the retention of urine.Therefore it is considered that prostate
The contractile function of detrusor muscles obstacle pathologic basis of hyperplasia disease are " kidney lose gasification, stasis blocking water channel ", kidney lose gasification for disease this, stasis blocking
Water channel is the mark of disease.
The content of the invention
In order to solve the above problems, kidney deficiency blood stasis type benign prostate hyperplasia is treated it is an object of the invention to provide one kind
Chinese medicine of detrusor urinae of bladder dysfunction and preparation method thereof, can effectively solve to treat kidney deficiency blood stasis type benign prostate hyperplasia
The problem of detrusor urinae of bladder dysfunction effect on driving birds is not good.
To achieve these goals, the technical solution adopted in the present invention is：
A kind of Chinese medicine for treating kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction, including following original
Material medicine：Semen Cuscutae 15-30g, Fructus Corni 14-16g, fruit of Cherokee rose 14-16g, calcined Dragon's bone 20-30g, semen allii tuberosi 15-20g, the Radix Astragali
30-45g, amber 2.5-3.5g, boiling hot leech 3-5g, fructus alpiniae oxyphyllae 15-20g, mantis egg-case 10-15g, field pennycress 20-30g, radix cyathulae
14-16g。
A kind of preparation method of the Chinese medicine for treating kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction,
Each material medicine is mixed, is put into container, the 700-900ml that adds water soaks 25-35 minutes, fries by intense fire to boiling,
It is changed to be cooked by slow fire 18-22 minutes, filters, reserved filtrate is obtained final product.
The present invention is made of medicine in pure natural raw material, organic cooperation between various medicines, Synergistic, is prepared and is closed
Reason, abundant raw material, method is simple, convenient to take, good effect, low cost, is treatment benign prostate hyperplasia detrusor urinae of bladder
A big innovation on dysfunction medicine.
Specific embodiment
Specific embodiment of the invention is described in further detail with reference to embodiments.
Embodiment 1
The Chinese medicine of present invention treatment kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction, including it is following
Material medicine：Semen Cuscutae 15g, Fructus Corni 14, fruit of Cherokee rose 14g, calcined Dragon's bone 20g, semen allii tuberosi 15g, Radix Astragali 30g, amber 2.5g, scald
Leech 3g, fructus alpiniae oxyphyllae 15g, mantis egg-case 10g, field pennycress 20g, radix cyathulae 14g.
The preparation method of the Chinese medicine, each material medicine is mixed, and is put into container, and the 700ml that adds water soaks 25 points
Clock, is fried by intense fire to boiling, is changed to be cooked by slow fire 18 minutes, and filtering, reserved filtrate is obtained final product.
Embodiment 2
The Chinese medicine of present invention treatment kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction, including it is following
Material medicine：Semen Cuscutae 18g, Fructus Corni 15g, fruit of Cherokee rose 15g, calcined Dragon's bone 25g, semen allii tuberosi 18g, Radix Astragali 40g, amber 3g, scald
Leech 4g, fructus alpiniae oxyphyllae 18g, mantis egg-case 12g, field pennycress 25g, radix cyathulae 15g.
The preparation method of the Chinese medicine, each material medicine is mixed, and is put into container, and the 800ml that adds water soaks 30 points
Clock, is fried by intense fire to boiling, is changed to be cooked by slow fire 20 minutes, and filtering, reserved filtrate is obtained final product.
Embodiment 3
The Chinese medicine of present invention treatment kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction, including it is following
Material medicine：Semen Cuscutae 30g, Fructus Corni 16g, fruit of Cherokee rose 16g, calcined Dragon's bone 30g, semen allii tuberosi 20g, Radix Astragali 45g, amber 3.5g,
Scald leech 5g, fructus alpiniae oxyphyllae 20g, mantis egg-case 15g, field pennycress 30g, radix cyathulae 16g.
The preparation method of the Chinese medicine, each material medicine is mixed, and is put into container, and the 900ml that adds water soaks 35 points
Clock, is fried by intense fire to boiling, is changed to be cooked by slow fire 22 minutes, and filtering, reserved filtrate is obtained final product.
The present invention is every according to this it is noted that claimed technological core of the invention is prescription (Chinese medicine compound prescription)
Decoction, pill, pulvis, capsule, tablet that herbal mixture is made, belong to claimed scope of the invention.
In said medicine, wherein：
Semen Cuscutae, alias abdicates true, beans parasitism, beans King of Hell, yellow silk, Huang Siteng, reticulate millettia, spun gold rattan etc..Annual parasitism
Draft.Semen Cuscutae is sweet, temperature, returns kidney,liver,spleen to pass through, and the effect of with nourishing liver and kidney, astringent sperm contracting urine, antiabortive, improving eyesight, antidiarrheal, begins to carry
《Sheng Nong's herbal classic》, it is listed in top grade.Sugariness typically have tonic effect, sweet pungent tepor, report gas neutralize, both can yang-tonifying, again may be used
It is beneficial cloudy, with warm but not dry, mend without it is stagnant the characteristics of.Controlling nocturnal emission with astringent drugs is antiabortive and gonadotropic Effect.The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution,
Interior residence Kidney-Yin and Yuanyang, are the root of human body reproductive development, the motive power of internal organs functional activity.
The Radix Astragali, also known as astragali or northern alpine yarrow, also makees astragalus or yellow alpine yarrow, is the root of legume astragalus mongolicus or Astragalus membranacus.
Main product is in the Inner Mongol, Shanxi, the Heilungkiang of China and other places.Spring and autumn is excavated, and several heads of fibrous root of going out are dried, and is cut into slices, raw to use
Or honey processs use.This moral character is sweet, taste tepor, return lung, spleen, liver and kidney channel.With invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation
Effect.For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, long
Burst and do not hold back, blood deficiency chlorosis, Heat Diabetes.The modern medicine study Radix Astragali has enhance immunity, liver protection, antifatigue, anti-aging, anti-
Scorching, antiulcer action.
Fructus Corni, alias medicine jujube, cornus, fructus corni.This product is the drying and ripening pulp of Cornaceae plant Fructus Corni.Main product
In Zhejiang.Slightly warm in nature, it is sour, puckery, return liver and kidney channel.Stop with tonify the liver and kidney, restrain astringent or styptic treatment for spontaneous sweating, astringent sperm contracting urine, stop-band collapse, hidroschesis,
The work(for promoting the production of body fluid to quench thirst.Cure mainly soreness of waist and knee joint, dizziness and tinnitus, forgetful, emission and spermatorrhea, enuresis frequent micturition, uterine bleeding under band, irregular menstruation,
Profuse sweating collapse, Heat Diabetes.This product mends that power is gentle with it, establishing-Yang without helping fire, enriching yin and oiliness diaphragm, restrain without staying the spies such as heresy
Distinguished service effect likes use by successive dynasties medical science.Modern medicine study has the pharmacological actions such as enhancing immune, anti-inflammatory, antibacterial.
The fruit of Cherokee rose, alias：Hemiplelea davidii, Rosa roxburghii, golden small-mouthed jar, Randia spinosa, pheasant chieftain, sugared warbler, sugar bowl, candy, honeybee
Sugar bowl, betel nut, golden tall bottle with spout, sugared orange, yellow tea bottle, rattan hook, mantis fruit, sugared bur, cape gooseberry, thorn olive, cape gooseberry, thorn
Blue stalk.It is the dry mature fruit of the rosaceous plant fruit of Cherokee rose, is harvested when 10~November fruit maturation reddens, dry, removes
Burr.This product is mild-natured, sour, sweet, puckery, returns kidney, bladder, large intestine channel, with astringent sperm contracting urine, the work(of relieving diarrhea with astringents.Modern study
It was found that：In the fruit of Cherokee rose containing substantial amounts of acidic materials, soap into etc., can controlling nocturnal emission with astringent drugs room prevent man pass out semen lingering diarrhea, woman's under band mistake
It is many, and can puckery enteron aisle, the rush down dysentery caused by preventing insufficiency of the spleen constraint ineffective；Reducing urination for preventing enuresis.Contain substantial amounts of acidic materials in the fruit of Cherokee rose
And saponin, with the de- sphincter of restriction wing, extend interval between micturition, increase the effect of discharge urine volume every time, can be used to treat
The disease of the enuresis and frequent urination；It is relieving cough and asthma, anti-spasm.The composition containing anti-smooth muscle spasm, can prevent stomach and intestine in the fruit of Cherokee rose
And the spasm of tracheae；Anti-inflammation.Recent study finds that fruit of Cherokee rose extract solution can kill staphylococcus aureus and large intestine bar
Bacterium etc., can be used to treat the disease caused by S. aureus L-forms or coli-infection.
Keel, alias：Lu Hu loses life, that gal bone, Os Draconis, calcined Dragon's bone, five OS DRACONISs, green grass or young cropsization keel, OS DRACONIS, Bai Long
Bone.The fossil of the skeleton for ancient times mammal like an elephant class, rhinoceros class, Hippocampal cortex etc..After digging out keel, soil and miscellaneous is removed
Matter.Five OS DRACONIS matter are crisp, and after being unearthed, dew is easily crushed in being empty gas, is commonly used writing paper made from bamboo and is pasted.This product is mild-natured, sweet-puckery flavor, returns
The heart, liver, kidney, large intestine channel, the work(with tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, myogenic sore cure mainly that frightened epilepsy is demented, palpitation
Forgetful, insomnia and dreamful sleep, spontaneous sweating, seminal emission stranguria with turbid discharge, hematemesis is had blood in stool, uterine bleeding under band, rush down dysentery prolapse of the anus, ulcer do not close up long.
Semen allii tuberosi, is the seed of herbaceos perennial leek.Rural area is born in, there are cultivation, Henan (flat-top in all parts of the country
Mountain) yield is larger.Infructescence is harvested during autumn fruit maturation, is dried, rub seed, remove impurity.This product is warm in nature, taste is pungent, sweet, returns
Kidney, Liver Channel, with filling liver kidney, warm waist and knee, supporing yang, controlling nocturnal emission with astringent drugs work(, cure mainly impotence, seminal emission, enuresis frequent urination, soreness and weakness of waist and knees,
Crymodynia, leukorrhea.
Amber, also known as：Jin Po, blood amber, screen amber, Hua Po, reddish brown amber, Lan Po, green amber, worm amber, beeswax, amber root.It is ancient times
Coniferale, the resin of legume, are embedded in the older fossil sample material in stratum.Used time need to remove the impurity such as sandstone, soil,
Used time smashs to pieces, is ground into fine powder use.This product is mild-natured, sweet, the thoughts of returning home, liver, small intestinl channel, bladder, lung, the spleen channel, with calmness, diuresis,
The work(of promoting blood circulation, cures mainly the diseases such as infantile convulsion, epilepsy, palpitaition, insomnia, difficult urination, odynuria, hematuria, amenorrhoea.Written by Northern and Southern Dynasties' Tao Hongjing
's《Mingyi Bielu》The large effect of amber three of summary is：One is to compose oneself, and two is promoting blood circulation to remove blood stasis, and three is inducing diuresis for treating strangurtia.Amber
It is treatment prostatic disorders common drug.
Leech, is that drying for Hirudinidae animal leech, leech or whitmania acranulata Whitman is all.Also known as Zhi Nao, to the palm, Ji, Qi, horse
Black horse, horseleech, horseleech etc..Summer, autumn catch, and catch rear clean, are first suffocated with lime or wine, then dry or dry and be medicinal.Mild-natured,
It is poisonous, the salty hardship of taste, Return liver, bladder warp, the work(of the carbuncle that disappears with promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dredging collateral,《This warp》Speech：It is " main by evil
Blood, hemostasis, the moon are closed, the accumulation of blood-breaking lump in the abdomen, s.m.p, dredging water passages." to contain protein.Also various trace elements such as iron content, manganese, zinc.Newly
Containing a kind of anticoagulative substance name hirudin (Hirudin) in fresh leech saliva, belong to polypeptide, due to not having in its molecular composition
Tryptophan and arginine, therefore have blood coagulation resisting function.But it has been destroyed medicinal material reclaimed water leech element is dried.Also secretion has in leech saliva
Histamine sample material, heparin and antithromboxin etc., synergy is have with leech.Modern research suggests that, hirudin can prevent blood coagulation
Enzyme hinders blood clotting to fibrinous effect.Hirudin be not heated or ethanol destruction.Leech still secretes a kind of histamine
Sample material, thus expansible capillary and increase bleeding；Leech has expansion capillary, improves microcirculation, increases kidney blood
The effect of flow.Its effect for improving microcirculation, similar with heparin, simply action time is of short duration.Experiment shows：Leech has expansion
Peripheral vascular, the effect for increasing CBF and reduction vascular resistence, the effect are similar to papaverine hydrochloride effect.
Fructus alpiniae oxyphyllae, is the fruit of zingiberaceous plant intelligence development.Guangdong and Hainan are distributed in, also there is cultivation in Fujian, Guangxi, Yunnan.
2-3 after field planting, in the 6-7 months, comes off when fruit, when pulp band is sweet, seed is pungent in light brown, White flesh, selects the fine day will
Fruit ear is cut, and removes carpopodium, dries or dries.This product is warm in nature, taste is pungent, returns spleen, kidney channel, stops with warm kidney contracting urine controlling nocturnal emission with astringent drugs, warm spleen
The effect of taking the photograph saliva is rushed down, crymodynia, many salivas of mouth in enuresis with renal asthenia, frequent micturition, seminal emission, gonorrhoea, deficiency-cold in spleen and stomach, vomiting, diarrhea, abdomen are cured mainly
Deng disease.
Mantis egg-case, is the ootheca that dries of Mantidae insect Chinese mantid, maculated mantis or hierodula patellifera, and three of the above practises title respectively
" the group egg capsule of a mantis ", " egg capsule of a mantis long " and " the black egg capsule of a mantis ".Main product is in originating in Guangxi, Yunnan, Hubei, Hunan, Hebei, Liaoning, Henan, mountain
The ground such as east, Jiangsu, the Inner Mongol, Sichuan.Collection processing late autumn to secondary spring is collected, and removes impurity, is steamed to worm's ovum after death, is dried, and is used
When shred.This product is mild-natured, sweet, salty, returns liver and kidney channel, with astringent sperm contracting urine, tonify the kidney and support yang the effect of, cure mainly enuresis frequent micturition, lose
Smart involuntary emission, urine gonorrhoea.《This is through meeting original》：" mantis egg-case, the special inducing astrigency of work(, therefore man is deficient, impotence due to deficiency of the kidney, and essence is lost in dream, loses and drowns
Gonorrhoea side it is multiplex it.《This warp》Say that logical five drench again, diuresis water channel, lid takes lower burnt empty stagnant to let out.”
Field pennycress, is the herb of patrinia herb patrima villosa, patrinia scabiosaefolia Fiscs, also known as bitter benefit dish, HERBA THALASPIS, penny cress.
Patana, roadside are born in, in addition to northwest, are distributed all over China.Young young stem and leaf after results will in time clean, dry,
Chopping is used, and is otherwise susceptible to go mouldy, if run into the cloudy day to dry in time, it is impossible to stack.This product is cool in nature, taste is pungent, hardship, returns
Stomach, large intestine, Liver Channel, with clearing heat and detoxicating, promoting diuresis and pus discharge, promoting blood circulation and removing blood stasis, swelling and pain relieving work(, cure mainly prostatitis, appendicitis,
Dysentery, enteritis, hepatitis, eye conjunctivitis, postpartum blood stasis stomachache, carbuncle swells furunculosis.Field pennycress pharmacological action has：1. resisting pathogenic microbes
Effect.Patrinia scabiosaefolia Fiscs oral liquid, patrinia scabiosaefolia Fiscs electuary, patrima villosa electuary have stronger suppression to make to staphylococcus aureus
With the decocting liquid of, patrima villosa in chicken embryo infected by influenza without substantially suppression toxic effect really, but its extract then has obvious suppression poison
Effect, Patrinia scaniosaefolia preserved material has slight inhibitory action to staphylococcus aureus, staphylococcus albus, diphtheroid in vitro；It is right
Hemolytic streptococcus, corynebacterium diphtheriae, pneumococcus, bacillus anthracis and clostridium tetani are without effect.2. sedation.Patrinia scabiosaefolia Fiscs
There is sedation, saponin contained therein is its active ingredient, and the ethanol extract or volatile oil of patrinia scabiosaefolia Fiscs are oral, have bright to mouse
Aobvious sedation, and the syngignoscism of yellow Jackets can be strengthened.3. hepatic cholagogic effect.Patrinia scaniosaefolia has hepatitis virus resisting, makes
Liver cell inflammatory resolution and bile capillaries dredging are acted on, and have promotion liver cell regeneration, prevent degeneration of liver cells, are improved liver function and are made
With .4., other are acted on.Experiment in vitro shows:, patrinia heterophylla and patrinia scabra Bunge have strong antitumaous effect to cancer cell, different leaf with
Patrinia scabra Bunge water extract has direct killing effect to mouse peritoneal injection to ascitic type S180 oncocytes.
Radix cyathulae, is the dry root of amaranthaceous plant radix cyathulae, also known as berry-bearing campion root, turns the root of bidentate achyranthes, beef cattle knee.Main product in Sichuan,
The ground such as Guizhou, Yunnan, Hebei, Shaanxi, Hunan.Autumn, the excavation of season in winter two, except removing LU, fibrous root and silt, clean, and run through, and cut thin
Piece, dries or shines to half-dried, stacks backwash, then dry or dry.This product is mild-natured, sweet, slight bitter, returns liver and kidney channel, logical with diuresis
Pouring, dispelling stasis of blood and stimulating the menstrual flow, easing joint movement work(, cure mainly cards such as hematuria blood drenches, Amenorrhea abdominal mass, placenta retension, injury from falling down, arthralgia pain due to rheumatism, foot
Impotence muscle contraction etc. is demonstrate,proved.《Clinical conventional Chinese medicine handbook》Speech：Radix cyathulae hardship overweights sweet, the power broken through relatively victory, and invigorate blood circulation, dissolving stasis are stopped
Bitterly, the multiplex radix cyathulae of hemostasis real example is controlled.
In said medicine, Fructus Corni slightly warm in nature is sour, puckery, returns liver and kidney channel, with tonifying the liver and kidney, astringent sperm contracting urine, convergence
Astringent or styptic treatment for spontaneous sweating, stop-band stop collapse, hidroschesis, the work(that promotes the production of body fluid to quench thirst；Amber is mild-natured, sweet, the thoughts of returning home, liver, small intestinl channel, bladder, lung, the spleen channel, tool
There are inducing diuresis for treating strangurtia, promoting blood circulation to remove blood stasis, arresting convulsion to compose oneself three large effects；The two is altogether monarch drug in a prescription, for kidney deficiency blood stasis card type, plays help liver
Kidney, contracting urine promoting blood circulation, the work(of the powdered medicine ' Tongluosan ' stasis of blood.
Semen allii tuberosi is warm in nature, taste is pungent, sweet, returns kidney, Liver Channel, with filling liver kidney, warm waist and knee, supporing yang, controlling nocturnal emission with astringent drugs work(, helps Fructus Corni
Kidney tonifying；The Radix Astragali is sweet, taste tepor, return lung, spleen, liver and kidney channel, with invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, the work(of expelling pus and promoting granulation
Effect, bowl spares gas, benefit are congenital, strengthen the function of the main water of kidney；The fruit of Cherokee rose is mild-natured, sour, sweet, puckery, returns kidney, bladder, large intestine channel, has
Astringent sperm contracting urine, the work(of relieving diarrhea with astringents helps Fructus Corni kidney-nourishing contracting urine；Leech is mild-natured, poisonous, the salty hardship of taste, and Return liver, bladder warp have
Promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dredging collateral disappear the work(of carbuncle, help amber disperse blood stasis and dredge collateral, inducing diuresis for treating strangurtia；Four is altogether ministerial drug.
Field pennycress is cool in nature, taste is pungent, hardship, returns stomach, large intestine, Liver Channel, with clearing heat and detoxicating, promoting diuresis and pus discharge, promoting blood circulation and removing blood stasis, detumescence
The work(of analgesic, both can help amber, leech to act on promoting blood circulation and removing blood stasis, inducing diuresis and reducing edema.Can be eliminated with clearing heat and detoxicating, stagnation resolvation apocenosis again
The adjoint inflammation of benign prostatic hyperplasis；Fructus alpiniae oxyphyllae is warm in nature, taste is pungent, returns spleen, kidney channel, with warm kidney contracting urine controlling nocturnal emission with astringent drugs, warming spleen and stopping diarrha
The effect of taking the photograph saliva, cures mainly the diseases such as enuresis with renal asthenia, frequent micturition, gonorrhoea；Mantis egg-case is mild-natured, sweet, salty, returns liver and kidney channel, with controlling nocturnal emission with astringent drugs contracting
The effect of urinating, tonify the kidney and support yang；Fructus alpiniae oxyphyllae matches somebody with somebody mantis egg-case, and the two is tonified the kidney and support yang, the work(of astringent sperm contracting urine is stronger.Calcined Dragon's bone is mild-natured, taste
It is sweet puckery, the thoughts of returning home, liver, kidney, large intestine channel, the work(with tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, myogenic sore.Keel match somebody with somebody leek
Son, can increase Fructus Corni, fructus alpiniae oxyphyllae, effect of mantis egg-case with kidney tonifying Yiyang, astringent sperm contracting urine.Keel match somebody with somebody amber, can be pacified with calmness
God, treatment Benign Prostatic Hypertrophy frequent urination at night, the symptom of sleep difference；Four is altogether adjutant, and one helps monarch-minister drug kidney tonifying Yiyang,
Two assistant monarch-minister drug astringent sperm contracting urines, three assistant monarch-minister drugs are promoting blood circulation and removing obstruction in channels, and four can play clearing heat and detoxicating, diuresis antiinflammation.
Radix cyathulae is mild-natured, sweet, slight bitter, returns liver and kidney channel, except with inducing diuresis for treating strangurtia, dispelling stasis of blood and stimulating the menstrual flow, it is easing joint movement it
Work(, it is played in side should have effect outer, and also as medicine is made, priming is descending.(Chinese medicine preparation is adjusted, monarch relation
Accordingly to adjust.Lower clinical data please be check simultaneously, the content of adjustment in need is seen whether)
Full side selects that medicine is fine, prescription is rigorous, efficient combination, compatibility are proper, Synergistic, kidney tonifying Yiyang, promoting blood circulation is played altogether logical
Network, astringent sperm contracting urine, clearing heat and detoxicating work(.The party and by clinic application, achieves good effect, and its relevant information is as follows.
1 Western medicine diagnostic criteria
1.1 hyperplasia of prostate diagnostic criteria BPH diagnostic criteria references《5th international benign prostate hyperplasia consulting
Opinion is recommended by the committee》Draft
1. there is lower urinary tract symptom (LUTS)；
②>50 years old males；
3. international contest (IPSS)>13；
4. appraisal of life quality (QoL)>3；
5. proved by pathology BPH.
1.2 FBOOs and detrusor function obstacle evaluation criteria
Pressure-volume and pressure-flow study are carried out using U.S.'s Medtronic companies DUET urodynamics instrument, according to
International norm operating procedure is carried out.In continuous mode, record Qmax, the sensation of bladder, capacity, bladder are complied with
Property, the amplitude, the Detrusor contractility that whether there is DI, DI, pressure-flow rate analysis judges FBOO (BOO).According to
Schaefer nomograms, 0-7 rank is divided into by degree, Detrusor contractility is divided into and very weak, weak subtracted, weak added, normally subtract, just
Often add and strong 6 ranks.We very weak, weak will subtract again, weak plus be defined as Detrusor contractility and be damaged, normally subtract, normally plus,
It is defined as Detrusor contractility strongly good.All urodynamics test results are all sentenced through more than two this subject study persons
It is fixed, to exclude illusion.
2 Standards of Chinese Medical Syndrome Differentiation
TCM syndrome diagnostic criteria reference《New Chinese medicine guideline of clinical investigations》(issuing within 1997),《The Chinese people
Republic's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect》Draft standard:
2.1 kidney qis are weak：
Primary symptom：Frequent urination, night is more so；Urinary obstruction or drop are not well；Acraturesis, range shortens；Small distention and fullness in the abdomen,
Urine drop and go out or do not go out；The urinary incontinence.
Secondary disease：Soreness and weakness of waist and knees；Urine is clarified；The enuresis；Scrotum is clammy；Impotence or seminal emission；Lusterless complexion；The cold limb of shape is cold.
Tongue vein：Tongue is weak is fat, white and moist fur, slow and sunken pulse or thin and delicate.
2.2 stasis blocking water channels：
Primary symptom：Urine drop and under, or off and on, or renal shutdown is obstructed；Urine is thin such as line；Splitting of urinary stream.
Secondary disease：Lower abdominal distention pain；Perineum distending pain；Blood urine；Essence goes out puckery pain or blood sperm.
Tongue vein：Tongue is weak purple or purple dark or petechia ecchymosis or the channels varicose of tongue bottom, uneven pulse or thin puckery.
Possesses primary symptom
1+secondary disease, 2+tongue vein, or primary symptom 2+1+tongue vein of secondary disease, you can diagnosis.
3 inclusive criterias
1. the age is between 50~85 years old；
2. the Western medicine diagnostic criteria of benign prostate hyperplasia is met；
3. meet that traditional Chinese medical science kidney qi deficiency is weak and the CM syndrome differentiation criterion of stasis blocking water channel card；
4. urodynamics test Detrusor contractility be classified as extremely weak (VW) and it is weak subtract (W-), it is weak plus (W+) patient；
5. Informed Consent Form is signed.
4 exclusion standards
1. urodynamics test Detrusor contractility is classified normal and enhanced patient；
2. color ultrasound is shown：The prostate volume person of significantly increasing；
3. to this medicine allergy or intolerant to receptor；
4. being associated with unmanageable diabetes and diabetic neuropathy and medical history or physical examination prompting has nervous system
The patient of disease；
5. the severe primary such as serious cardiovascular, liver and hemopoietic system disease and mental patient are associated with；
6. there are the Diseases such as prostate cancer, ankylurethria, neck of urinary bladder hardening, neurogenic bladder, interstitial cystitis；
7. there is the patient of pelvic surgery operation or trauma history；
8. needing application simultaneously may influence pharmaceutical effectiveness and safety evaluatio medicine person；
9. the situation for having any discomfort preferably selected is thought in studying.
5 come off standard and rejecting standard：
5.1 exit experiment case standard
1. there is allergic reaction or serious adverse events person, judging according to doctor should the person of stopping.
2. sb.'s illness took a turn for the worse in the course of disease, and being judged according to doctor should the person of stopping.
3. patient's compliance during clinical test is poor, is unwilling to proceed curer.
5.2 cases come off and treatment
The definition for coming off：Observation case is included, into random packet person, no matter when what is because exiting, as long as no completion
The observation cycle person of scheme defined, referred to as come off case.Disappeared voluntarily drug withdrawal person less than 1 course for the treatment of symptom, not as de-
Fall case.After subject comes off, researcher subject's contact, inquiry reason, record last time medicine time, completion institute energy
The evaluation item of completion.Because of allergic reaction, adverse reaction, failing to respond to any medical treatment and exiting experiment case, researcher should be according to subject
Actual conditions, take corresponding remedy measures.Patient that is every selected and having used numbering, regardless of whether coming off, all should record
With reservation case observation table.Patient come off without separately mending.All cases that come off all should collect the data such as case observation table, statistics
Analysis.
The rejecting of 5.3 cases
Doctor's advice drug application curer is not pressed；Given without any data person after randomisation and rejected.
6 packets and research method
The subject of 60 qualified entrance randomized tests of screening is divided into 2 groups, treatment group by random digits table at random
Using treatment by Chinese herbs of the present invention, control group is using the logical granule therapy of father-in-law's drip.This research using random, double blinding, parallel, control face
Bed test method, research approach is carried out after submitting a report asking for Hospital Ethical Committee's examination ＆ approval.
7 treatment methods
Treatment group uses treatment by Chinese herbs of the present invention, and daily 1 dose, decocting takes juice 400ml, and a point morning and evening warmly takes after meal twice.It is right
According to group using a father-in-law's logical granule therapy of drip, 2 times a day, 2 bags every time, is washed into decoction by nurse and gives patient after meal sooner or later and warmly takes.2 groups
Equal 4 weeks is 1 course for the treatment of, and the course for the treatment of counts curative effect after terminating.
8 observation index
8.1 main effects indexs：International contest (I-PSS), appraisal of life quality (QOL), bladder outlet
Obstruction (BOO) degree, Detrusor contraction power.
1. international contest (I-PSS)：0-35 points.It is shown in Table 1
Patient can be classified as follows：0-7 points=mild；8-19 points=moderate symptoms；20-35 points=severe
Symptom.
2. appraisal of life quality (QOL)：It is shown in Table 1.
The international contest of table 1 and appraisal of life quality table
3. FBOO (BOO) degree, Detrusor contraction power：It is dynamic using Medtronic companies of U.S. DUET urine
Mechanics instrument is detected, strictly carried out by standard.
8.2 secondary efficacy indexs：Average 24h number of micturitions, average enuresis nocturna number of times, prostate volume, residual urine volume, maximum
Urinary flow (Qmax), symptom and sign and auxiliary examination classification score standard.
1. average 24h number of micturitions=continuous 3d urinations total degree/3
2. average enuresis nocturna number of times=continuous 3d enuresis nocturna total degree/3
3. prostate volume (V=0.52 × anteroposterior diameter × left and right footpath × up and down footpath) and residual urine volume (ml).By Ultrasonography
Special messenger is responsible for, and is detected with color ultrasound.
4. Qmax (Qmax)：Detected using U.S.'s Medtronic companies DUET urodynamics instrument, strictly pressed
Standard is carried out.
5. symptom and sign and auxiliary examination is classified score standard：It is shown in Table 2.
The symptom and sign of table 2 and auxiliary examination classification score standard
8.3 clinical information gather time point：Before treatment, treat and terminate within 4 weeks to carry out These parameters collection respectively
8.4 Safety Evaluation Indexes：Hepatic and renal function, electrocardiogram, blood routine, routine urinalysis, stool routine, courage type-B ultrasonic.
9 efficacy assessment standards
9.1 comprehensive therapeutic effect evaluation criteria
1. it is effective：Symptom is obviously improved, and prostate touch has improvement or prostate volume to reduce, residual urine volume
More than 60% is reduced, detrusor urinae of bladder contraction intensity improves more than II grade or reaches normal earlier above；
2. it is effective：Symptom slightly improves, and residual urine volume reduces scope 30%~59%, and detrusor urinae of bladder shrinks strong
Degree improves more than I grade；
3. it is invalid：Symptom is reduced without improvement, residual urine volume<30%, detrusor urinae of bladder contraction intensity is earlier above also without changing
Kind or exacerbation.
9.2 symptoms improve degree evaluation standard
1. it is obviously improved：I-PSS reduces 60%-99%；
2. it is slight to improve：I-PSS reduces scope between 30%-59%；
3. without improvement：I-PSS is reduced<30%.
9.3 residual urine volumes improve degree evaluation standard
1. improve completely：Residual urine volume is wholly absent；
2. it is obviously improved：Residual urine volume reduces 60%-99%；
3. it is slight to improve：Residual urine volume reduces scope between 30%-59%；
4. without improvement：Residual urine volume is reduced<30% or residual urine volume increase.
9.4 contraction force of bladder detrusor improve evaluation criteria
1. III grade is improved：Contraction force of bladder detrusor score reduces 3 points；
2. II grade is improved：Contraction force of bladder detrusor score reduces 2 points；
3. I grade is improved：Contraction force of bladder detrusor score reduces 1 point；
4. without improvement：Contraction force of bladder detrusor score is without reduction or increases on the contrary.
10 statistical methods
1. measurement data：Test of normality is first carried out, meeting normal distribution person carries out t inspections or variance analysis, variance point
Homogeneity test of variance is carried out before analysis.Compare between two groups using t inspections, do not meet normality distribution person then using sum of ranks inspection between two groups
Test；Itself compare using paired t-test (Paired-Samples T Test) before and after treatment in group, do not meet normality distribution
Person is then using pairing rank test (2Related Samples, Wilcoxon method).Multigroup is more conform with normality point two-by-two
The neat person of cloth, variance uses variance analysis (one-way ANOVA), compares between group use LSD methods two-by-two；Normal distribution or side are not met
The uneven person of difference uses Wilcoxon rank tests.
2. enumeration data：Using rank test, compare use Wilcoxon rank tests two-by-two；Compare use between two or more group
Kruskal-Wallis is checked.Compare between two population rates (or constituting ratio), use χ2Inspection or exact method method, multiple samples
Rate or composition than between compare, using contingency table χ2Inspection.
3. ranked data：Checked using Kruskal-Wallis H.
11 results
11.1 clinical efficacies
11.1.1 during general curative effect judges treatment group 30, effective, effective, invalid respectively 14,11,5, always have
Efficiency 83.33%.9,10,11, total effective rate 63.33% are respectively in control group 30.It is statistically analyzed display
Two groups of Different therapeutical effects have statistical significance (P ＜ 0.05).
11.1.2 symptom improves the comparing of degree
Two groups after a course for the treatment of is observed, all improve significantly to BPH symptoms, and treatment group is to the improvement rate of symptom
86.67 ﹪, control group is 66.67 ﹪ to the improvement rate of symptom, and being statistically analyzed two groups of symptoms improvement degree differences has statistics
Learn meaning (P ＜ 0.05).
11.1.3 contraction force of bladder detrusor improves degree
After one course for the treatment of of observation, two groups of contraction force of bladder detrusor have clear improvement.Treatment group's improvement rate is
80.00%, control group improvement rate is 60.00%.Being statistically analyzed two groups of improvement rate differences has statistical significance (P ＜
0.05)。
11.1.4 the improvement degree of residual urine volume
After one course for the treatment of of observation, two groups of residual urine volumes have a certain degree of improvement, and treatment group is to residual urine volume
Improvement rate is 86.67%, and the improvement rate of control group is 63.33%, and improvement rate difference has statistics between being statistically analyzed two groups
Meaning (P ＜ 0.05).
11.1.5 compare before and after I-PSS scorings and life quality scores treatment
After one course for the treatment of of observation, two groups of I-PSS scorings have substantially reduction, and treatment group is better than control group (P ＜ 0.05)；
More there is decline before and after two groups of life quality scores, comparing difference is not statistically significant between treatment is first two groups.It is shown in Table 3：
Table 3 treats front and rear I-PSS scorings and life quality scores change
Note：Compared with pre-treatment,*P ＜ 0.01；Compared with control group,#P ＞ 0.05,▲P ＜ 0.05.
11.1.6 Qmax (Qmax)
After a course for the treatment of is observed, two groups of Qmaxs are increased significantly, and there are significantly the difference of Qmax before and after treatment
Property meaning (P ＜ 0.05)；Two groups of differences for comparing Qmax have significant (P ＜ 0.05) after treatment.It is shown in Table 4：
Compare before and after the Qmax of table 4 (ml/s)
Note：Compared with pre-treatment,#P ＜ 0.05；Compared with control group after treatment,▲P ＜ 0.05
11.1.7 compare before and after average 24h number of micturitions, the treatment of average enuresis nocturna number of times
Two groups after a course for the treatment of is observed, average 24h number of micturitions and average enuresis nocturna number of times have substantially reduction, between two groups
Comparing difference is not statistically significant (P ＞ 0.05).It is shown in Table 5：
Change before and after the treatment forward backward averaging 24h of table 5 urinations, the treatment of average enuresis nocturna number of times
Note：Compared with control group,*P ＞ 0.05.
11.1.8 the comparing of prostate volume
Two groups observe a course for the treatment of after, prostate volume without significant change, two groups of control no difference of science of statistics (P ＞
0.05) 6, are shown in Table：
Table 6 treats front and rear prostate volume (cm3) change
Note：Compared with control group,*P ＞ 0.05.
11.2 safety indexes abnormal rate situations
It is statistically analyzed, treatment group and control group items safety indexes blood, urine, stool routine, electrocardiogram, liver function, kidney
Work(, courage type-B ultrasonic, relatively without significant difference (P ＞ 0.05) before and after treatment.
11.3 adverse reactions
In the different phase of medication, two groups of patients occur without obvious adverse reaction.Hepatic and renal function, courage type-B ultrasonic, electrocardio
Figure, blood routine, routine urinalysis, stool routine inspection shows no obvious abnormalities.
Conclusion
Shown by above-mentioned, Chinese medicine of the present invention is reliable and stable, therapeutic effect is good, instant effect has no toxic side effect, in treatment kidney deficiency
In blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction, the symptoms such as controlled micturition difficulty can be relieved, reduced
Enuresis nocturna number of times, reduces residual urine volume, increases contraction force of bladder detrusor, reduces international contest and quality of life is commented
Point, for benign prostate hyperplasia detrusor urinae of bladder dysfunction provides good treatment condition, effective percentage reaches
83.33%, it is the big creation on traditional Chinese medicine and pharmacy, there is actual clinical meaning, it is that treatment kidney deficiency blood stasis type benign prostate increases
A big innovation on raw disease detrusor urinae of bladder dysfunction medicine, there is good social and economic benefit.
Claims (5)
1. a kind of Chinese medicine for treating kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction, it is characterised in that
Including following material medicine：Semen Cuscutae 15-30g, Fructus Corni 14-16g, fruit of Cherokee rose 14-16g, calcined Dragon's bone 20-30g, semen allii tuberosi
15-20g, Radix Astragali 30-45g, amber 2.5-3.5g, boiling hot leech 3-5g, fructus alpiniae oxyphyllae 15-20g, mantis egg-case 10-15g, field pennycress 20-
30g, radix cyathulae 14-16g.
2. in treatment kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction according to claim 1
Medicine, it is characterised in that including following material medicine：Semen Cuscutae 15g, Fructus Corni 14, fruit of Cherokee rose 14g, calcined Dragon's bone 20g, semen allii tuberosi
15g, Radix Astragali 30g, amber 2.5g, boiling hot leech 3g, fructus alpiniae oxyphyllae 15g, mantis egg-case 10g, field pennycress 20g, radix cyathulae 14g.
3. in treatment kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction according to claim 1
Medicine, it is characterised in that including following material medicine：Semen Cuscutae 18g, Fructus Corni 15g, fruit of Cherokee rose 15g, calcined Dragon's bone 25g, semen allii tuberosi
18g, Radix Astragali 40g, amber 3g, boiling hot leech 4g, fructus alpiniae oxyphyllae 18g, mantis egg-case 12g, field pennycress 25g, radix cyathulae 15g.
4. in treatment kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder dysfunction according to claim 1
Medicine, it is characterised in that including following material medicine：Semen Cuscutae 30g, Fructus Corni 16g, fruit of Cherokee rose 16g, calcined Dragon's bone 30g, semen allii tuberosi
20g, Radix Astragali 45g, amber 3.5g, boiling hot leech 5g, fructus alpiniae oxyphyllae 20g, mantis egg-case 15g, field pennycress 30g, radix cyathulae 16g.
5. a kind for the treatment of kidney deficiency blood stasis type benign prostate hyperplasia detrusor urinae of bladder work(as described in claim any one of 1-4
The preparation method of the Chinese medicine of energy obstacle, it is characterised in that each material medicine is mixed, is put into container, add water 700-
900ml is soaked 25-35 minutes, fries by intense fire to boiling, is changed to be cooked by slow fire 18-22 minutes, filters, and reserved filtrate is obtained final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938833A (en) * | 2018-09-20 | 2018-12-07 | 河南中医药大学 | A kind of Chinese medicine for treating benign prostate hyperplasia and detrusor urinae of bladder dysfunction |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014126269A1 (en) * | 2013-02-12 | 2014-08-21 | 주식회사 한국전통의학연구소 | Pharmaceutical composition for improving male sexual function and for treating infertility |
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2017
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014126269A1 (en) * | 2013-02-12 | 2014-08-21 | 주식회사 한국전통의학연구소 | Pharmaceutical composition for improving male sexual function and for treating infertility |
Non-Patent Citations (1)
| Title |
|---|
| 瞿岳云: "《中医妙方全书（珍藏本）》", 31 July 2016, 湖南科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938833A (en) * | 2018-09-20 | 2018-12-07 | 河南中医药大学 | A kind of Chinese medicine for treating benign prostate hyperplasia and detrusor urinae of bladder dysfunction |
| CN108938833B (en) * | 2018-09-20 | 2021-04-13 | 河南中医药大学 | Traditional Chinese medicine for treating benign prostatic hyperplasia and bladder detrusor dysfunction |
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| CN106902306B (en) | 2020-06-23 |
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