CN107137446A - The tripterygium wilfordii prepared slices of Chinese crude drugs that a kind of desmodium processes - Google Patents
The tripterygium wilfordii prepared slices of Chinese crude drugs that a kind of desmodium processes Download PDFInfo
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- CN107137446A CN107137446A CN201710552815.4A CN201710552815A CN107137446A CN 107137446 A CN107137446 A CN 107137446A CN 201710552815 A CN201710552815 A CN 201710552815A CN 107137446 A CN107137446 A CN 107137446A
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- desmodium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to the tripterygium wilfordii prepared slices of Chinese crude drugs that desmodium processes, the distinguished but toxicity of tripterygium wilfordii curative effect very big drug safety can effectively be solved the problems, such as, its solve technical scheme be, the medicine materical crude slice is made up of desmodium and Tripterygium Wilfordii Cut Crude Drugs using mass ratio of 1 ︰ 3 12 as raw material, the decocting that desmodium is added into 68 times of desmodium weight first is boiled twice, merge decocting liquid twice, it is the desmodium decocting liquid equivalent to the 0.1g/mL containing crude drug amount 0.025 to be concentrated into concentration；Tripterygium Wilfordii Cut Crude Drugs are added in desmodium decocting liquid, are placed in stainless-steel pan, is simmered in water most to the saturating juice of medicine, is taken out, be placed in 60 DEG C of dryings in far infrared constant temperature drying box, the Tripterygium Wilfordii Cut Crude Drugs processed into desmodium.Abundant raw material of the present invention, preparation method is simple, effectively reduces the toxicity of tripterygium wilfordii, improves curative effect and medical value, opened up the use value of tripterygium wilfordii, there is significant economic and social benefit.
Description
Technical field
The present invention relates to medicine, the tripterygium wilfordii prepared slices of Chinese crude drugs that particularly a kind of desmodium processes.
Background technology
Tripterygium wilfordii is the dry root or root of Celastraceae plant tripterygium wilfordii (Tripterygium wilfordii Hook.f.)
Xylem, it is cold in nature, it is bitter, pungent, return liver and kidney channel, effect dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, swelling and pain relieving and desinsection removing toxic substances have
The multiple biological activities such as anticancer, resisting rheumatoid arthritis, anti diabetes and kidney disease, immunosupress, the distinguished but toxicity of curative effect is very big,
One of most Chinese herbal medicine of poisoning occurs for report since as nearly half a century, and especially outstanding behaviours is in hepatotoxicity wind agitation and kidney poison
Property.
Traditional Chinese medical theory thinks, " desmodium kills tripterygium wilfordii poison ", i.e., desmodium can suppress the toxicity of tripterygium wilfordii, desmodium
The category for belonging to Chinese medicine mutual-detoxication compatibility is shared with tripterygium wilfordii.Tcm clinical practice also has with the report of desmodium solution Tripterygium wilfordii Poisoning.
Processing is the important administration features of the traditional Chinese medical science, by appropriately process can play attenuation or (and) effect of synergy.With
A kind of medicine appropriately processes another medicine, with play process attenuation or (and) purpose of synergy, have it from ancient times, such as pinellia,
Sweet lily, cornel coptis etc..It is major auxiliary burden that the present invention chooses the desmodium for having " mutual-detoxication " compatibility relationship with tripterygium wilfordii first
Medicine, it is intended to develop the efficient tripterygium wilfordii prepared slices of Chinese crude drugs of low toxicity, is that the effective medication of tripterygium wilfordii clinical safety lays the foundation.But so far not
See the open report for thering is desmodium to process Tripterygium Wilfordii Cut Crude Drugs.
The content of the invention
For above-mentioned situation, to overcome the defect of prior art, the purpose of the present invention is just to provide a kind of desmodium and processed
The tripterygium wilfordii prepared slices of Chinese crude drugs, can effectively solve the problems, such as the distinguished but toxicity of tripterygium wilfordii curative effect very big drug safety.
The technical scheme that the present invention is solved is that the medicine materical crude slice is made original by desmodium and Tripterygium Wilfordii Cut Crude Drugs by 1 ︰ 3-12 of mass ratio
Material is made, and the decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, merges decocting liquid twice, being concentrated into concentration is
Desmodium decocting liquid equivalent to the 0.025-0.1g/mL containing crude drug amount；Tripterygium Wilfordii Cut Crude Drugs are added in desmodium decocting liquid, are placed in
In stainless-steel pan, simmer in water most to the saturating juice of medicine, take out, 60 DEG C of dryings in far infrared constant temperature drying box are placed in, into desmodium big gun
The Tripterygium Wilfordii Cut Crude Drugs of system.
Abundant raw material of the present invention, preparation method is simple, effectively reduces the toxicity of tripterygium wilfordii, improves curative effect and medicinal valency
Value, has opened up the use value of tripterygium wilfordii, has there is significant economic and social benefit.
Embodiment
The embodiment to the present invention elaborates with reference to embodiments.
Embodiment 1
The present invention is in specific implementation, and the medicine materical crude slice is made up of desmodium and Tripterygium Wilfordii Cut Crude Drugs using mass ratio of 1 ︰ 3 as raw material,
The decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, merges decocting liquid twice, be concentrated into concentration for equivalent to containing
Crude drug amount 0.1g/mL desmodium decocting liquid；Tripterygium Wilfordii Cut Crude Drugs are added in desmodium decocting liquid, are placed in stainless-steel pan, are used
It is cooked by slow fire to the saturating juice of medicine and uses up, takes out, be placed in 60 DEG C of dryings in far infrared constant temperature drying box, the tripterygium wilfordii drink processed into desmodium
Piece.
Embodiment 2
The present invention is in specific implementation, and the medicine materical crude slice is made up of desmodium and Tripterygium Wilfordii Cut Crude Drugs using mass ratio of 1 ︰ 6 as raw material,
The decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, merges decocting liquid twice, be concentrated into concentration for equivalent to containing
Crude drug amount 0.05g/mL desmodium decocting liquid；Tripterygium Wilfordii Cut Crude Drugs are added in desmodium decocting liquid, are placed in stainless-steel pan, are used
It is cooked by slow fire to the saturating juice of medicine and uses up, takes out, be placed in 60 DEG C of dryings in far infrared constant temperature drying box, the tripterygium wilfordii drink processed into desmodium
Piece.
Embodiment 3
The present invention is in specific implementation, and the medicine materical crude slice makees raw material system by desmodium and Tripterygium Wilfordii Cut Crude Drugs by 1 ︰ 12 of mass ratio
Into the decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, merges decocting liquid twice, it is suitable to be concentrated into concentration
In the desmodium decocting liquid of the 0.025g/mL containing crude drug amount；Tripterygium Wilfordii Cut Crude Drugs are added in desmodium decocting liquid, stainless-steel pan is placed in
It is interior, simmer in water most to the saturating juice of medicine, take out, be placed in 60 DEG C of dryings in far infrared constant temperature drying box, the Thunder God processed into desmodium
Rattan medicine materical crude slice.
The Tripterygium Wilfordii Cut Crude Drugs that desmodium of the present invention processes have dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, swelling and pain relieving and desinsection removing toxic substances,
There are the multiple biological activities such as anticancer, resisting rheumatoid arthritis, anti diabetes and kidney disease, immunosupress, and through experiment
Extraordinary advantageous effects are achieved, relevant experimental data is as follows：
1.1 experiment materials and method
1.1.1 animal subject
Kunming (KM) mouse, male, SPF grades, 18~22g of weight provides [SCXK by experimental animal center of henan province
(Henan) 2015-0004].S180 lotus knurl ascites tumor mouse, are provided by Institute Of Chinese Materia Medica Of China Academy of Chinese Medical Sciences.
1.1.2 test medicine
The Tripterygium Wilfordii Cut Crude Drugs for taking tripterygium wilfordii health product and desmodium to process, are placed in round-bottomed flask, are separately added into 10 times of amounts
Ethyl acetate or 20%~95% ethanol, soak 1 hour, carry out refluxing extraction 3 times, 2 hours every time, 4000r/min centrifugations point
From supernatant, merge 3 supernatants, ethyl acetate be recovered under reduced pressure extremely without ethyl acetate taste, or ethanol is recovered under reduced pressure extremely without alcohol taste,
(60 DEG C) are dried under reduced pressure, the ethyl acetate or 20%~95% ethanol of the Tripterygium Wilfordii Cut Crude Drugs that tripterygium wilfordii health product and desmodium process is obtained
Extract medicinal extract test medicine.
1.2 experimental method
1.2.1 the passage of tumour cell and inoculation (S180 solid tumors)
S180 tumor-bearing mices grow 7d, and cervical dislocation puts to death tumor-bearing mice, its belly is carried out with medicinal alcohol and Iodophor
Sterilize, aseptic aspiration S180 tumor-bearing mice milky ascites (is placed on ice) into sterile EP pipes, add immediately pre- twice
Cold sterile saline dilutes 2 times, and extracting 0.2mL from the tumour cell diluted is quickly injected intraperitoneally normal mouse, conventional to raise
Support, observation passage tumor-bearing mice situation takes the eugonic tumor-bearing mices of 9d, continues to pass on, according to needed for experiment, decision is passed
Algebraically.
The vigorous S180 cell kind mouse cervical dislocations of 7d will be grown to put to death, it is sterile to take mouse milky ascites, use sterile life
Manage salt solution and dilute 5 times.Extract S180 tumor cell inoculations under tumor cell suspension, aseptic condition in mouse right fore axillary region
Subcutaneously, 0.2mL/.
1.2.2 animal packet and administration
Next day is inoculated with oncocyte, mouse is randomly divided into 7 groups：Model, model+positive drug 5 FU 5 fluorouracil (5-Fu,
25mg/kg), model+tripterygium wilfordii health product, model+tripterygium wilfordii process medicine materical crude slice A (desmodium/tripterygium wilfordii=1/3), model+tripterygium wilfordii
Process medicine materical crude slice B (desmodium/tripterygium wilfordii=1/6), model+tripterygium wilfordii and process medicine materical crude slice C (desmodium/tripterygium wilfordii=1/12) group, separately
10 intact animals are taken as Normal group.
Tripterygium wilfordii health product and the different equal gavage of processed product group (ig) administration (0.2ml/10g), dosage be 60mg/kg (by
Preliminary experiment is determined), model group and the isometric 0.5%CMC-Na of the equal ig of Normal group, one time a day, continuous 14d.15d plucks eye
Ball is taken a blood sample, and is removed tumor mass and is weighed, and tumour inhibiting rate is calculated by formula.
1.2.3 the collection and processing of sample
In after 14d last doses 24 hours, eyeball is plucked to mouse progress and takes blood, takes into an EP pipes, carries out corresponding mark
Note, 30min, 3000r/min centrifugation 15min are stood in 4 DEG C of refrigerators, serum is separated, packing is after preservation in -20 DEG C of refrigerators
It is standby, determine serum liver function indexes glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST) and kidney work(index creatinine (Cr), urea
Nitrogen (BUN).
1.2.4 solid tumor is gathered
Water is can't help in fasting after last dose, is plucked eyeball and is taken after blood, and cervical dislocation puts to death mouse, and the right oxter of mouse is splitted immediately
Crust, clip solid tumor washes away blood and mucus with physiological saline, and weighs rapidly after being blotted with filter paper.Tumor growth inhibition
Rate (Inhibition Rate, IR)=(the average knurl weight of the average knurl weight/model control group of 1- experimental groups) × 100%.
1.2.5 ELIASA detects blood parameters
Test 15d to put to death after mouse, take mouse orbit serum, survey Serum Indexes ALT, AST, Cr, BUN, it is specific by south
Capital is built up all kinds of indicator reagent box specifications of Bioengineering Research Institute and carried out.
1.2.6 statistical procedures method
Data analysis carries out the statistical procedures of data information with the medical statistics bags of SPSS 17.0, and measurement data is with averagely
Number ± standard deviationRepresent, compare between each group and use one-way analysis of variance, the neat person of variance test uses LSD methods, and variance is not
Neat person is examined with Games-Howell methods.
1.3 experimental result
1.3.1 influence of the prepared slices of Chinese crude drugs of the present invention to mice with tumor knurl weight
As shown in table 1, compared with model group, positive drug 5-Fu and the prepared slices of Chinese crude drugs of the present invention can make mice with tumor knurl weight pole
Significantly reduce (P<0.01), prompting positive drug and the prepared slices of Chinese crude drugs of the present invention show aobvious in the experiment of mouse S180 solid tumors
Write antineoplastic action；Compared with tripterygium wilfordii health product group, through desmodium according to mass ratio 1:3~1:After 12 process, tripterygium wilfordii is each
Processing medicine materical crude slice group mouse knurl weight significantly reduces (P<0.05 or P<0.01), tumor control rate increase 10.94%~
18.75%, wherein tumour inhibiting rate rise at most, illustrates after being processed through desmodium during using desmodium and tripterygium wilfordii mass ratio as 1/6
The Tripterygium Wilfordii Cut Crude Drugs (desmodium/tripterygium wilfordii=1/3~1/12) of generation, antitumor activity is significantly increased, wherein during especially with 1/6
It is preferred.Found after further being compared with positive drug 5-Fu groups, mass ratio is at 1/3~1/6, with 5-Fu no difference of science of statistics (P>
0.05) medicine materical crude slice after present invention processing, is pointed out, antitumor action is suitable with 5-Fu effects.
The prepared slices of Chinese crude drugs of the present invention of table 1 to mice with tumor knurl weight influence (n=10,)
Compared with model group,#P<0.01；Compared with tripterygium wilfordii health product, * P<0.05, * * P<0.01
1.3.2 the prepared slices of Chinese crude drugs of the present invention are to mice with tumor liver function, the influence of kidney work(
As shown in table 2, compared with normal group, positive drug 5-Fu and tripterygium wilfordii health product medicine materical crude slice can make S180 solid tumor mouse
Serum liver function indexes ALT and AST, kidney work(index Cr and BUN significantly raise (P<0.05), prompting positive drug 5-Fu and tripterygium wilfordii life
Product medicine materical crude slice causes the hepatotoxicity wind agitation and renal toxicity of mice with tumor；Compared with tripterygium wilfordii health product group, through desmodium according to mass ratio 1:3
~1:After 12 process, it is notable that tripterygium wilfordii respectively processes medicine materical crude slice group mice serum liver function indexes ALT and AST, kidney work(index Cr and BUN
Reduce (P<0.05 or P<0.01) Tripterygium Wilfordii Cut Crude Drugs (desmodium/tripterygium wilfordii=1/3 of the generation after being processed through desmodium, is illustrated
~1/12) reduce liver poison and kidney poison caused by tripterygium wilfordii.
The prepared slices of Chinese crude drugs of the present invention of table 2 to mice with tumor liver function, kidney work(influence (n=10,
Compared with normal group,&P<0.05；Compared with model group,#P<0.05；
Compared with tripterygium wilfordii health product group, * P<0.05, * * P<0.01
Above-mentioned experiment can be clearly showed, be compared with tripterygium wilfordii health product medicine materical crude slice, the tripterygium wilfordii drink after being processed through desmodium
Piece, not only antitumor action is improved, and liver poison and kidney poison are also reduced；Medicine materical crude slice effect of the present invention and positive drug 5-Fu phases
When, and avoid liver poison and renal toxicity caused by 5-Fu.Illustrate that Chinese herb triperygium wilfordii medicine materical crude slice of the present invention has antitumor low toxicity high
Effect is acted on, and has been opened up the medical value of the safe and efficient medication of tripterygium wilfordii, has been that creative contribution is made in the development of traditional Chinese medicine and pharmacy, has
Significant economic and social benefit.
Claims (4)
1. the tripterygium wilfordii prepared slices of Chinese crude drugs that a kind of desmodium processes, it is characterised in that by desmodium and Tripterygium Wilfordii Cut Crude Drugs with mass ratio
It is made up of 1 ︰ 3-12 as raw material, the decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, merges decocting liquid twice,
It is the desmodium decocting liquid equivalent to the 0.025-0.1g/mL containing crude drug amount to be concentrated into concentration；Tripterygium Wilfordii Cut Crude Drugs are added into desmodium
In decocting liquid, it is placed in stainless-steel pan, simmers in water most to the saturating juice of medicine, take out, is placed in far infrared constant temperature drying box 60 DEG C and does
Tripterygium Wilfordii Cut Crude Drugs that are dry, being processed into desmodium.
2. the tripterygium wilfordii prepared slices of Chinese crude drugs that desmodium according to claim 1 processes, it is characterised in that by desmodium and Thunder God
Rattan medicine materical crude slice is made up using mass ratio of 1 ︰ 3 as raw material, and the decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, is closed
And decocting liquid twice, it is the desmodium decocting liquid equivalent to the 0.1g/mL containing crude drug amount to be concentrated into concentration；Tripterygium Wilfordii Cut Crude Drugs are added into gold
In money grass decocting liquid, it is placed in stainless-steel pan, simmers in water most to the saturating juice of medicine, take out, be placed in 60 in far infrared constant temperature drying box
DEG C drying, the Tripterygium Wilfordii Cut Crude Drugs processed into desmodium.
3. the tripterygium wilfordii prepared slices of Chinese crude drugs that desmodium according to claim 1 processes, it is characterised in that by desmodium and Thunder God
Rattan medicine materical crude slice is made up using mass ratio of 1 ︰ 6 as raw material, and the decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, is closed
And decocting liquid twice, it is the desmodium decocting liquid equivalent to the 0.05g/mL containing crude drug amount to be concentrated into concentration；Tripterygium Wilfordii Cut Crude Drugs are added
In desmodium decocting liquid, it is placed in stainless-steel pan, simmers in water most to the saturating juice of medicine, take out, be placed in far infrared constant temperature drying box
60 DEG C of dryings, the Tripterygium Wilfordii Cut Crude Drugs processed into desmodium.
4. the tripterygium wilfordii prepared slices of Chinese crude drugs that desmodium according to claim 1 processes, it is characterised in that by desmodium and Thunder God
Rattan medicine materical crude slice is made up using mass ratio of 1 ︰ 12 as raw material, and the decocting that desmodium is added into 6-8 times of desmodium weight first is boiled twice, is closed
And decocting liquid twice, it is the desmodium decocting liquid equivalent to the 0.025g/mL containing crude drug amount to be concentrated into concentration；Tripterygium Wilfordii Cut Crude Drugs are added
In desmodium decocting liquid, it is placed in stainless-steel pan, simmers in water most to the saturating juice of medicine, take out, be placed in far infrared constant temperature drying box
60 DEG C of dryings, the Tripterygium Wilfordii Cut Crude Drugs processed into desmodium.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109856084A (en) * | 2019-03-26 | 2019-06-07 | 河南中医药大学 | A kind of stomach pill of aucklandia and amomum fruit condensed pill preparation process quality monitoring method |
-
2017
- 2017-07-07 CN CN201710552815.4A patent/CN107137446A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 李桓等: "雷公藤"异类相制"配伍减毒作用探讨", 《中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109856084A (en) * | 2019-03-26 | 2019-06-07 | 河南中医药大学 | A kind of stomach pill of aucklandia and amomum fruit condensed pill preparation process quality monitoring method |
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Application publication date: 20170908 |