CN107050311A - It is a kind of to treat cerebral infarction, the medicine of miocardial infarction - Google Patents
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction Download PDFInfo
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Abstract
The invention discloses it is a kind of treat cerebral infarction, miocardial infarction medicine, be made up of the raw material of following parts by weight：50~150 parts of the Radix Astragali, 5~20 parts of Radix Angelicae Sinensis, 5~22 parts of the radix paeoniae rubrathe, 5~20 parts of earthworm, 4~20 parts of Ligusticum wallichii, 5~22 parts of bush, 4~20 parts of safflower, 5~22 parts of peach kernel, 5~22 parts of the root of fangji, 4~20 parts of cassia seed, 5~22 parts of rhizoma Gastrodiae, 10~35 parts of the red sage root, 5~20 parts of raw bark of eucommia, 5~20 parts of yncaria stem with hooks, 3~20 parts of jujube kernel, 3~18 parts of the seed of Oriental arborvitae.Medicine of the present invention is relieved effect to the symptom such as pain, shock, cerebral disorder caused by cerebral infarction, miocardial infarction early stage, it will not develop immunity to drugs, also it is without any side effects in therapeutic effect, patient body will not be caused harm, cerebral infarction, miocardial infarction can be prevented and treated well.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly to a kind of treat cerebral infarction, the medicine of miocardial infarction.
Background technology
Infraction is a kind of symptom of organ ischemia's property necrosis, and most common and death rate highest is exactly that cerebral infarction obstructs with cardiac muscle
Plug, cerebral infarction is mainly in the crowd of more than 50~60 years old, often there is atherosclerosis, hypertension, rheumatic heart disease, coronary heart disease or glycosuria
It is before disease, onset to have premonitory symptom more, show as headache, dizziness, dizziness, transience extremity numbness, powerless.Onset is typically relatively delayed
Slowly, many onsets in quiet and sleep of patient, most of patients symptom peaks through a few houres even 1~3 day state of an illness.Cardiac muscle stalk
Have acutely and more lasting retrosternal pain during plug onset, heating, leukocytosis, erythrocyte sedimentation rate (ESR) are accelerated, serum cardiac
Enzyme activity increases and progressive ECG Change, can occur arrhythmia cordis, shock or heart failure.
Think that cerebral infarction, miocardial infarction are developed by rheumatism in theory of traditional Chinese medical science, positive unsaturated vapor, exopathogen invasion and attack are this disease
Basic pathogenesis.The principle of Chinese traditional treatment infraction is exactly that clearing and activating the channels and collaterals, promoting blood circulation and removing blood stasis, softening blood is reached by traditional Chinese herbal decoction
Pipe, the effect of qi-regulating tonifying Qi, fundamentally prevention and treatment are blocked.
Cerebral infarction, taking good care of for Patients With Myocardial Infarction are mainly taken good care of by diet and life style：1st, the fine drink of residence is taken
Food：It was found that water miscible food fiber helps to reduce the content of cholesterolemia.This fiber sees barley, beans, rough
Rice, fruit, glucosylmannitol, guar natural gum, oat.It is to reduce the optimal selection of cholesterol in oat bran and brown rice chaff.Cause
Mineral matter in being assimilated food for fiber, therefore mineral matter need to be additionally supplemented, but do not used simultaneously with fiber.Under
Row food is also good selection：Almond fruit, brewer's yeast, cereal, raw goat milk and raw goat milk product, sesame；2nd, reduce as far as possible
The intake of vitamin D：Vitamin D is not obtained in the dairy products of high fat, this based food easily facilitates artery occlusion.It should avoid homogenizing
Product, such as milk and other dairy products.These products that homogenize contain xanthine oxidase, can destroy artery and cause to move
Arteries and veins is hardened；3rd, do not smoke and drink the pungent such as drink coffee, it is high not eat cholesterol level in red meat, red meat, is artery sclerosis
The big of patient is avoided, and drinks barley water more；4th, essential fatty acid is supplemented：Essential fatty acid is considerable to health.Required fat
Acid can not be made by oneself and need not lean on the aliphatic acid of food supply in vivo.Three kinds of essential fatty acids are linolenic acid, secondary flax respectively
Oleic acid and arachidonic acid；5th, supplement the nutrients element：1. choline, lecithin and inositol, lecithin in taking 1 soupspoon before the meal, this
A little material assistances remove the fat in liver and blood；2. Co-Q10, can play the oxygen and work of improvement cardiac muscle by daily 100 milligrams
With；3. it is appropriate to supplement element and the vitamin As, vitamin B complex, vitamin C, vitamin E, these nutrients such as solarization, copper, calcium, magnesium
Beneficial heart is to maintaining the rhythm of the heart and blood pressure normally helpful；5th, some helpful natural medicinal herbs：Black radiss, butcher's broom, white bend
Dish, dandelion, fennel, ginkgo (gingko), haw berry, hop, scouring rush, Irish moss, Lobelia sessilifolia, Sheep's-parsley, HONGMUXU, rose
Real, they all have help to the treatment of miocardial infarction.
In life, cerebral infarction, Patients With Myocardial Infarction should 1, the absolutely not overweight article of lift to move, it is inevitable during lift to move weight
Bend over to hold one's breath, its physiological effect, with firmly holding one's breath substantially similar, is the common cause that aged coronary heart disease people induces miocardial infarction；
2nd, mind at rest, happiness life keeps mental state gentle, and anything be able to will be taken calmly；Participate in appropriate sports but answer
Match with keen competition is avoided, also should be for the purpose of taking exercises and heighten the enjoyment, not with victory or defeat opinion height even if match；3rd, appropriateness
Take exercise, in general, to reach the purpose of exercise, at least there are three conscientious physical trainings weekly, 20 points are no less than every time
Clock, but also no more than 50 minutes；4th, it should not be had a bath in the case of heavy meal or starvation, water temperature is preferably suitable with body temperature, water temperature
Too high skin heart is substantially expanded, a large amount of blood flow to body surface, can cause cardiac-cerebral ischemia.Bathtime is unsuitable long, washes
General sultry and stuffy between bath, the metaboilic level of people is higher in such an environment, easily anoxic, fatigue；5th, it is noted that weather
Change, under the influence of severe cold or strong cold air, coronary artery can occur spasm and secondary thrombus and cause acute myocardial infarction.
When weather drastically changes, air pressure is low, patients with coronary artery disease can feel substantially there is discomfort.Data shows that low temperature, strong wind, wet weather are anxious
One of inducement of myocardial inyaretion.So when awful weather, patients with coronary artery disease is it is noted that warming, or suitably adds coronary dilatation medicine
Thing is protected.
Doctor trained in Western medicine is it could be theoretically argued that infraction is human vas hardening, and rubbish is excessively caused in blood, treats on the market at present
Cerebral infarction and the medicine of miocardial infarction mainly have a Folium Ginkgo, aspirin enteric coated tablet, metoprolol tartrate tablets etc., these medicines
Thing treatment cycle is long, cures the symptoms, not the disease, and toxic side effect, and long-term prescription can develop immunity to drugs, so that curative effect is had a greatly reduced quality.
The content of the invention
Realizing the technical scheme of foregoing invention purpose is：For above-mentioned problems of the prior art and defect, this hair
Bright purpose be for many patients provide it is a kind of treat cerebral infarction, miocardial infarction medicine, medicine of the present invention is to cerebral infarction, the heart
The symptom such as pain, shock, cerebral disorder is relieved effect caused by muscle infarction early stage, will not develop immunity to drugs,
It is also without any side effects in therapeutic effect, patient body will not be caused harm, cerebral infarction, cardiac muscle can be prevented and treated well
Infraction.
The invention provides it is a kind of treat cerebral infarction, miocardial infarction medicine, be made up of the raw material of following parts by weight：
50~150 parts of the Radix Astragali, 5~20 parts of Radix Angelicae Sinensis, 5~22 parts of the radix paeoniae rubrathe, 5~20 parts of earthworm, 4~20 parts of Ligusticum wallichii, bush 5~
22 parts, 4~20 parts of safflower, 5~22 parts of peach kernel, 5~22 parts of the root of fangji, 4~20 parts of cassia seed, 5~22 parts of rhizoma Gastrodiae, the red sage root 10~35
Part, 5~20 parts of raw bark of eucommia, 5~20 parts of yncaria stem with hooks, 3~20 parts of jujube kernel, 3~18 parts of the seed of Oriental arborvitae.
The invention provides it is a kind of treat cerebral infarction, miocardial infarction medicine, by the raw material group of following preferred weight number
Into：
80~105 parts of the Radix Astragali, 10~18 parts of Radix Angelicae Sinensis, 11~18 parts of the radix paeoniae rubrathe, 11~16 parts of earthworm, 9~15 parts of Ligusticum wallichii, bush
11~18 parts, 9~15 parts of safflower, 11~18 parts of peach kernel, 11~18 parts of the root of fangji, 9~15 parts of cassia seed, 11~18 parts of rhizoma Gastrodiae is red
15~28 parts of ginseng, 10~18 parts of raw bark of eucommia, 10~18 parts of yncaria stem with hooks, 8~14 parts of jujube kernel, 8~15 parts of the seed of Oriental arborvitae.
The invention provides it is a kind of treat cerebral infarction, miocardial infarction medicine, by the raw material group of following optimum weight number
Into：
95 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of the radix paeoniae rubrathe, 15 parts of earthworm, 12 parts of Ligusticum wallichii, 12 parts of bush, 12 parts of safflower, peach kernel 12
Part, 12 parts of the root of fangji, 12 parts of cassia seed, 12 parts of rhizoma Gastrodiae, 20 parts of the red sage root, 15 parts of raw bark of eucommia, 15 parts of yncaria stem with hooks, 10 parts of jujube kernel, the seed of Oriental arborvitae
10 parts.
Below to effect of each taste medicine in formula in the present invention, the compatibility relationship of formulation of drug and monarch, minister, help, make
Elaborate：
The 16 kinds of Chinese medicines applied in the medicine of the present invention all have suitable treatment in different levels to cerebral infarction, miocardial infarction
Effect.
The Radix Astragali, sweet, slightly warm in nature.Return lung, spleen, liver and kidney channel.The solid table of polishing, torr sore myogenic.Cure mainly physically weak spontaneous perspiration, chronic diarrhea,
Prolapse of the anus, the prolapse of uterus, chronic nephritis, physically weak edema, chronic ulcer, the long disunion of the open sore part.1. the invigorating qi for consolidating superficies life Radix Astragali, beneficial
Superficies-consolidating, inducing diuresis for removing edema, detoxification, effect of myogenic, it is adaptable to which spontaneous perspiration, night sweat, blood-arthralgia, edema, ulcer are not burst or burst and do not hold back long
Deng disease.2. benefiting qi and nourishing blood preparing astragalus membranaceus has effect in tonifying Qi, blood-nourishing, benefit, it is adaptable to internal injury overstrain, splenasthenic diarrhea, the deficiency of vital energy, blood
The diseases such as void, laboured breathing.3. hypotensive modern medicine is proved, the Radix Astragali has reduction blood viscosity, reduces thrombosis, reduction blood
Pressure, cardioprotection, bidirectional modulation blood glucose, Green Tea Extract damage, anti-aging, anti anoxia, antitumor, enhancing immunity of organism masterpiece
With can be used to treat the diseases such as heart disease, hypertension, diabetes.The Radix Astragali can also expand blood vessel, improve skin blood circulation and nutrition
Situation, thus it is effective to the long disunion person of chronic ulcer.It can also eliminate the albuminuria of nephritis patient, protect liver, prevent glycogen
Original is reduced.
Radix Angelicae Sinensis, warm-natured, acrid-sweet flavor.The thoughts of returning home, liver, the spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation.Control irregular menstruation,
Amenorrhea is suffered from abdominal pain, and abdominal mass knot gathers, uterine bleeding；Headache due to deficiency of blood, dizziness, Impotence numbness；Intestines are dry and shit is difficult, weight after dysentery characterized by blood in the stool；Ulcer sore is stolen, and is fallen and is flutterred damage
Wound.1. body hematopoiesis function can be remarkably promoted by enriching blood, rise red blood cell, leucocyte and content of hemoglobin；2. Adjust-blood lipid suppresses
Platelet aggregation, antithrombotic adjusts blood fat；3. hypotensive resists myocardial ischemia, arrhythmia cordis, blood vessel is expanded, is reduced blood pressure；4. increase
Strong immunity strengthens immune, anti-inflammatory, liver protection, radioresistance, anti-oxidant and removing free radical etc..In addition, uterine leio can also be adjusted
Flesh.
The radix paeoniae rubrathe, bitter, cold nature；Return liver, the spleen channel.Clearing heat and cooling blood；Promoting blood circulation.Main febrile virulent maculae；Hematemesis and epistaxis；Intestines wind
Lower blood；Red eye, swell pain；Carbuncle swells sore；Amenorrhoea；Dysmenorrhoea；Collapse band stranguria with turbid discharge；The stagnant hypochondriac pain of the stasis of blood；Hernia lump in the abdomen is gathered；Injury from falling down.
Earthworm, cold in nature, taste is salty.Function：Heat-clearing, soothing the liver, Zhichuan, dredging collateral.Return liver, stomach, lung, bladder warp.Function heat-clearing is put down
Liver, relieving convulsion and spasm, relieving asthma, diuresis, dredging collateral eliminating impediment.Cure mainly hyperpyrexia agitation, twitch, dyspnea and cough due to lung-heat, thermojunction renal shutdown, numbness pain limb
Fiber crops, hemiplegia, and the card such as sore swollen toxin.Earthworm is longer than current channels and collaterals, for blockage of channel caused by many reasons, blood vessels
It is not smooth, the unfavorable card of podomere.Because its it is cold in nature can heat-clearing, therefore the hot numbness of Suitable therapeutic joint congestion and swelling pain, joint stuffiness, Chang Yufang
Oneself, bark of ash, caulis lonicerae etc. remove damp and hot, degrading the channel compatibility of drugs.Also with controlling wind-cold-dampness arthralgia, limbs joint numbness, pain, bend and stretch not
The diseases such as profit, can be with the compatibility, such as Xiao Huoluo Dan such as monkshood, rhizoma arisaematis, frankincense.Blood stagnancy due to deficiency of QI is treated, through network is unfavorable, half body after apoplexy
The diseases such as unsuccessful, facial paralysis, often with the compatibility, such as Buyang Huanwu Tang such as the Radix Astragali, Radix Angelicae Sinensis, Ligusticum wallichii.
Ligusticum wallichii, pungent, warm-natured, Return liver, courage, the heart channel of Hang-Shaoyin, gas perfume, which rises, to be dissipated, with blood-activating and qi-promoting, effect of wind-expelling pain-stopping.1st, it is living
Blood gas：1. it is used for coronary disease and angina pectoris, symptoms include chest distress, pareordia tenderness frequently send out author, can be with safflower, the red sage root, drop
The fragrant, radix paeoniae rubrathe is with use, No. 2 sides of coronary disease.2. the disease being used for caused by stagnation of QI-blood, such as preceded menstural cycle, the amount red person of polychrome, are blood-head,
It can be equal with the dried rhizome of rehmannia, moutan bark, Radix Angelicae Sinensis and use；It is delayed menstrual cycle, 1~2 month 1 time, white through waist stomachache, leukorrhea polychrome during row, with working as
Return, baked ginger, the bark of eucommia, Chinese cassia tree are equally used.3. it is used for dysmenorrhoea, if very, after pain seeing within 1 day through Attacking Midfielder's stomachache through with Radix Angelicae Sinensis, peach kernel, red
Hua Tongyong；If amenorrhoea is not all right, body without uncomfortable person, can with Radix Angelicae Sinensis, peach kernel, rhizoma zingiberis, Chinese cassia tree with use；If postpartum abdominal pain, with working as
Return, baked ginger is equally used.4. it is used for traumatic injury, partial gall, can be with cape jasmine, peach kernel, safflower with use.2nd, wind-expelling pain-stopping：1. use
In cold headache, the person that belongs to chill can be with schizonepeta, the windproof, root of Dahurain angelica with using；Belong to wind-heat person, can be with chrysanthemum, peppermint with use.②
For arthralgia pain due to rheumatism, can with notopterygium root, levisticum, windproof be equal to use.3rd, promote breath and open depression：1. it is used for the upper abdomen distending pain in hypochondrium of cholecystitis,
It can be equal with radix bupleuri, radix scutellariae and use.2. it is used for the cards such as abdominal distention and pain, acid regurgitation on gastritis be heartburn, can be equal with dandelion, the banksia rose and use.
Bush, sweet, salty, micro-pungent is put down.The thoughts of returning home, liver, the spleen channel.It is salty enter blood system, can invigorate blood circulation, stasis-dispelling and pain-killing.
Safflower, it is warm-natured, it is pungent.Cure mainly promoting blood circulation latus rectum, blood stasis removing analgesic.For Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen,
Traumatic injury.When ancients often have what blood in vivo, often add safflower tate：Gauze bag, which boils can use, twice a day steeps pin, is applicable
Various varication, blood circulation.
Peach kernel, the sweet flat, bitter of property, enters lung, liver, large intestine channel.Promoting blood circulation, relaxes bowel, relieving cough and asthma.For Amenorrhea,
Dysmenorrhoea , wei lump in the abdomen lump in the abdomens, injury from falling down, dry constipation of intestines.
The root of fangji, cold in nature, bitter is pungent, returns bladder, kidney, the spleen channel.There is inducing diuresis for removing edema, wind-expelling pain-stopping.Control oedema distension
Swollen, hygropyretic beriberi, brothers' contraction pain.With the root of gansui, lepidium seed compatibility, control oedema and be unable to prostration, and the Radix Astragali, cassia twig, Poria cocos compatibility, with
Strengthening the spleen and replenishing qi, warming yang for diuresis, and the Radix Astragali, the bighead atractylodes rhizome, radix glycyrrhizae compatibility, with invigorating qi for consolidating superficies, inducing diuresis for removing edema, with golden cypress, pawpaw, adlay etc.
Compatibility, controls damp and hot retardance channels and collaterals, tinea pedis and swells and ache.
Cassia seed, Return liver, kidney, large intestine channel.Effect：Can be invigorated blood circulation decompression, clearing liver kidney-nourishing, it is adaptable to hypertension, cerebral thrombus shape
Into there is thermal image, person takes.Can also heat-clearing improving eyesight, relax bowel.For the puckery pain of hot eyes, many tears of photophobia, dizziness of having a headache, mesh is secretly failed to understand,
Constipation, there is fat-reducing.
Rhizoma Gastrodiae, sweet, mild-natured, people's Liver Channel.Function is calming the liver, relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and only shies, clearing and activating the channels and collaterals.Rhizoma Gastrodiae can treat high blood
Pressure, long term usage can soothing the liver QI invigorating, benifit waist and knees, strengthening the bones and muscles, can also increase periphery and coronary blood flow, to heart have protection make
With.
The red sage root, bitter, cold nature；The thoughts of returning home, Liver Channel.Promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, blood-nourishing peace
God.Cure mainly irregular menstruation, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Liver and spleen swells
Greatly, angina pectoris.1. promoting blood circulation, can coronary artery dilator, increase coronary flow, improvement myocardial ischemia, infraction and cardiac function, regulation
The rhythm of the heart, and peripheral vascular can be expanded, improve microcirculation；Shorten the convalescence of red blood cell and hemochrome, increase Reticulocyte, energy
The reparation of promotion organization, accelerates the healing of fracture；2. body's hypoxia tolerance can be improved；3. pre- preventing thrombosis, there is anticoagulation, promote
Fibrinolytic, suppresses platelet aggregation, the effect of inhibition thrombosis；4. reducing blood lipid, can reduce blood fat, suppress coronary atherosclerosis shape
Into；5. protect liver, can suppress or mitigate degeneration of liver cells, necrosis and inflammatory reaction, promote liver cell regeneration, and have anti-fibrosis work
With；In addition, having inhibitory action to various bacterias such as tubercle bacilluses；6. it is antitumor, there can be nervous centralis to have inhibitory action；Have anti-swollen
Knurl is acted on；7. it is hypoglycemic to strengthen body's immunity 8..
Raw bark of eucommia, nature and flavor are sweet, micro-pungent, temperature, nontoxic, have functions that filling liver kidney, strengthening the bones and muscles, beneficial waist and knee, except aching, modern age doctor
Learning proves that the bark of eucommia has special efficacy for treatment vascular hypertension.In addition, raw bark of eucommia, which also has, removes internal rubbish, strengthen human body cell thing
Matter is metabolized, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat-clearing, broad-spectrum antiseptic, happiness maincenter god
Through improving white blood cell count, the remarkable efficacy such as body immunity.
Yncaria stem with hooks, sweet, slight bitter, cold nature；Return liver, pericardium channel；The latent drop of matter heavily fortified point, with The flat liver of heat-clearing, the work(of relieving convulsion and spasm
Effect, cures mainly irascibility superinverse headache and hot eyes, liver-yang hyperactivity is had a dizzy spell, and excess heat moves wind frightened epilepsy, child convulsion, the morbid night crying of babies, eclampsia, apoplexy
Paralysis, podomere contraction is anxious.
Jujube kernel, bitter, acid, puts down, the thoughts of returning home, Liver Channel.The primary efficacy of jujube kernel is replenishing blood for nourishing heart, antitoxic heart-soothing and sedative, often with Radix Angelicae Sinensis, white
Chinese herbaceous peony, the fleece-flower root, arillus longan with use, if heart kidney deficiency, the made restlessness of asrhenia type and insomnia of hyperactivity of yang due to yin deficiency, palpitaition, it is forgetful can be with radix scrophulariae, the dried rhizome of rehmannia
The yellow, seed of Oriental arborvitae is equally used.
The seed of Oriental arborvitae, sweet and have oil, gas micro-perfume is mild-natured nontoxic, enters the heart, liver, the spleen channel, there is certain anti-aging effects, clinical
Facts have proved it is preferable strengthening by means of tonics, mental-tranquilization good medicine simply.Every deficiency of blood old man, weak patients all can be through often to eat
With.Suitable for the disease of ferritic yin deficiency, the old dry constipation of intestines such as void declines, postpartum is thin and weak.In addition, honey is sweet and moist, it can slide sharp big
Intestines, it is for oral administration to make free movement of the bowels.It is physically weak and the very suitable of defaecation medicine should not be captured to dry constipation of intestines.Two medicines are cooked congee with rice,
Its taste is rather good, and patient is happy to take, and can receive strengthening by means of tonics, the effect of nourishing heart ease constipation.
The present invention treatment be with《The Yellow Emperor's Canon of Internal Medicine》In " Yin grows while yang is generating " be foundation, regenerated with the Chinese medicine with warm positive effect
Cardiac muscle cell, recovers the brain cell of impaired exhaustion, and " the moon is long " is to use to grow newborn cardiac muscle cell with the Chinese medicine for growing effect
Growth, repairs brain cell and myocardial ultramicrostructure.Foundation《The Yellow Emperor's Canon of Internal Medicine》The philosophic theory of " harmony between man and nature ", Man is the soul of the universe, people
Existence is among the Nature, and with nature changing rule breath manner of breathing connection, treatment infraction disease is also as a same reason.Chinese medicine of the present invention,
Curative effect is magical, and content is more, and scope is wide, be according to the state of an illness, it is different because of disease, vary with each individual, with clearing and activating the channels and collaterals, promoting blood circulation decompression, dispel
The stasis of blood is relieved pain, and softens blood vessel, the effects such as qi-regulating tonifying Qi, and the drug effect of medicine of the present invention can go directly cardiovascular and cerebrovascular, act on heart and brain and own
Artery, Vein blood pipe, including fine artery and vein, make its Rapid Expansion, and unobstructed blood flow lacks from basic mitigation, reduction blood vessel ischemic
Oxygen, improves artery, venous perfusion deficiency, strengthens cardio cerebral function, reach treatment cerebral infarction, the purpose of miocardial infarction.
Embodiment：
Below in conjunction with specific embodiment, the present invention will be described in detail.Testing the raw material of the use used includes：It is yellow
Stilbene, Radix Angelicae Sinensis, the radix paeoniae rubrathe, earthworm, Ligusticum wallichii, bush, safflower, peach kernel, the root of fangji, cassia seed, rhizoma Gastrodiae, the red sage root, raw bark of eucommia, yncaria stem with hooks, jujube kernel,
The seed of Oriental arborvitae.
The toxicity test of test example 1
The Radix Astragali that the present invention is selected, Radix Angelicae Sinensis, the radix paeoniae rubrathe, earthworm, Ligusticum wallichii, bush, safflower, peach kernel, the root of fangji, cassia seed, rhizoma Gastrodiae,
The red sage root, raw bark of eucommia, yncaria stem with hooks, jujube kernel, the Chinese medicine for the conventional integration of drinking and medicinal herbs that the seed of Oriental arborvitae is all was not only safe but also reliable.
Acute toxicity test：Using NIH mouse 80, SPF grades, male and female half and half, 16~22g of body weight carries out acute toxicity
Experiment.Mouse is randomly divided into two groups of administration group and control group, and every group 40, fasting 12h, medicine of the present invention is brewed into before experiment
Decoction so that concentration be 4.0g crude drugs/mL, gavage, gavage volume be 4.5mL/kg (i.e. unit dosage form be 18.0g crude drugs/
Kg), control group gives physiological saline, is administered 2 times within one day, and delivery time is Continuous Observation 14 days after 6h, administration, and is recorded
The toxic reaction and The dead quantity of mouse.Result of the test shows, is compared with control group, and administration group mouse has no notable difference, examination
Test Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase are normal.Administration group mouse is put to death in selection, micro-
Mouse core, liver are checked under mirror, spleen, lung, in stomach and the vitals such as thymus gland, is shown no obvious abnormalities.Therefore externally applied drug of the present invention
Thing acute toxicity is low, clinical application safety.
Long term toxicity test：Using SD rats, body weight 200g ± 10g, male and female half and half.Medicine of the present invention is brewed into decoction
Tested, prepare high, medium and low three dosage groups, respectively clinical application amount (adult's body weight in terms of 60kg, clinical application amount
For 9g crude drugs/day/people) 300,150,75 times, using gastric infusion mode, continuous use 20 weeks and after being discontinued 4 weeks, test knot
Fruit shows：Medicine of the present invention is to the hair of rat, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood
The indexs such as fat have no significant effect, and internal organs are virtually free from discovery, and substantially abnormal and histological indications show, medication 20
Week and be discontinued 4 weeks after, each internal organs of rat without substantially change.Illustrate external used medicine of the present invention to toxicity after rat long-term prescription
Small, also Non Apparent Abnormality reacts after drug withdrawal, using safety.
The contrast test of test example 2
Medicine of the present invention and other treatment cerebral infarction, the contrast test of miocardial infarction medication effect
Choosing is respectively divided into A at random with cerebral infarction (A groups) and each 100 of miocardial infarction (B groups) volunteer women1、A2、A3、
A4And B1、B2、B3、B4Totally eight test groups, record the disease condition of each volunteer in detail before the test, formulate effective standard and
Null criterion.A1、B1Group uses Folium Ginkgo, A2、B2Group uses aspirin enteric coated tablet, A3、B3Group uses tartaric acid Mei Tuoluo
That piece, A4、B4Group uses medicine of the present invention, and during testing, for the accuracy of result of the test, volunteer is in strict accordance with each
Carry out strict implement from the medicine specification used to use, other drugs must not be taken in addition, rule of working and resting should be kept, diet is clear
It is light, avoid tobacco and wine, viewing test result after 20 days, timing return visit week about during this, and record experimenter's using effect and sense
Think.Result of the test is as shown in table 1, table 2：
It can be seen from Tables 1 and 2 one kind of the present invention treat cerebral infarction, miocardial infarction medicine it is efficient 60% with
On, and other drugs effective percentage is below 10%.The data show the powerful therapeutic effect of medicine of the present invention, in experimental period
Between, had no adverse reaction using the volunteer of medicine of the present invention.
The cerebral infarction of table 1 (A groups) patient uses medicine of the present invention and other treatment cerebral infarction, miocardial infarction medication effect
Contrast test
The miocardial infarction of table 2 (B groups) patient is imitated using medicine of the present invention with other treatment cerebral infarction, miocardial infarction drug therapy
The contrast test of fruit
Embodiment 1
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction, it is made up of the raw material of following parts by weight：
50 parts of the Radix Astragali, 5 parts of Radix Angelicae Sinensis, 5 parts of the radix paeoniae rubrathe, 5 parts of earthworm, 4 parts of Ligusticum wallichii, 5 parts of bush, 4 parts of safflower, 5 parts of peach kernel, the root of fangji
5 parts, 4 parts of cassia seed, 5 parts of rhizoma Gastrodiae, 10 parts of the red sage root, 5 parts of raw bark of eucommia, 5 parts of yncaria stem with hooks, 3 parts of jujube kernel, 3 parts of the seed of Oriental arborvitae.
Embodiment 2
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction, it is made up of the raw material of following parts by weight：
80 parts of the Radix Astragali, 10 parts of Radix Angelicae Sinensis, 11 parts of the radix paeoniae rubrathe, 11 parts of earthworm, 9 parts of Ligusticum wallichii, 11 parts of bush, 9 parts of safflower, peach kernel 11
Part, 11 parts of the root of fangji, 9 parts of cassia seed, 11 parts of rhizoma Gastrodiae, 25 parts of the red sage root, 10 parts of raw bark of eucommia, 10 parts of yncaria stem with hooks, 8 parts of jujube kernel, the seed of Oriental arborvitae 8
Part.
Embodiment 3
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction, it is made up of the raw material of following parts by weight：
105 parts of the Radix Astragali, 18 parts of Radix Angelicae Sinensis, 18 parts of the radix paeoniae rubrathe, 16 parts of earthworm, 15 parts of Ligusticum wallichii, 18 parts of bush, 15 parts of safflower, peach kernel
18 parts, 18 parts of the root of fangji, 15 parts of cassia seed, 18 parts of rhizoma Gastrodiae, 28 parts of the red sage root, 18 parts of raw bark of eucommia, 18 parts of yncaria stem with hooks, 14 parts of jujube kernel, cedar seed
15 parts of benevolence.
Embodiment 4
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction, it is made up of the raw material of following parts by weight：
150 parts of the Radix Astragali, 20 parts of Radix Angelicae Sinensis, 22 parts of the radix paeoniae rubrathe, 20 parts of earthworm, 20 parts of Ligusticum wallichii, 22 parts of bush, 20 parts of safflower, peach kernel
22 parts, 22 parts of the root of fangji, 20 parts of cassia seed, 22 parts of rhizoma Gastrodiae, 35 parts of the red sage root, 20 parts of raw bark of eucommia, 20 parts of yncaria stem with hooks, 20 parts of jujube kernel, cedar seed
18 parts of benevolence.
Embodiment 5
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction, it is made up of the raw material of following parts by weight：
95 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of the radix paeoniae rubrathe, 15 parts of earthworm, 12 parts of Ligusticum wallichii, 12 parts of bush, 12 parts of safflower, peach kernel 12
Part, 12 parts of the root of fangji, 12 parts of cassia seed, 12 parts of rhizoma Gastrodiae, 20 parts of the red sage root, 15 parts of raw bark of eucommia, 15 parts of yncaria stem with hooks, 10 parts of jujube kernel, the seed of Oriental arborvitae
10 parts.
Embodiment 6
It is a kind of to treat cerebral infarction, the medicine of miocardial infarction, it is made up of the raw material of following parts by weight：
80 parts of the Radix Astragali, 10 parts of Radix Angelicae Sinensis, 11 parts of the radix paeoniae rubrathe, 11 parts of earthworm, 9 parts of Ligusticum wallichii, 11 parts of bush, 9 parts of safflower, peach kernel 11
Part, 11 parts of the root of fangji, 11 parts of cassia seed, 11 parts of rhizoma Gastrodiae, 15 parts of the red sage root, 10 parts of raw bark of eucommia, 10 parts of yncaria stem with hooks, 8 parts of jujube kernel, the seed of Oriental arborvitae 8
Part.
Claims (3)
1. a kind of treat cerebral infarction, the medicine of miocardial infarction, it is characterised in that is made up of the raw material of following parts by weight：
50~150 parts of the Radix Astragali, 5~20 parts of Radix Angelicae Sinensis, 5~22 parts of the radix paeoniae rubrathe, 5~20 parts of earthworm, 4~20 parts of Ligusticum wallichii, bush 5~22
Part, 4~20 parts of safflower, 5~22 parts of peach kernel, 5~22 parts of the root of fangji, 4~20 parts of cassia seed, 5~22 parts of rhizoma Gastrodiae, the red sage root 10~35
Part, 5~20 parts of raw bark of eucommia, 5~20 parts of yncaria stem with hooks, 3~20 parts of jujube kernel, 3~18 parts of the seed of Oriental arborvitae.
2. a kind of cerebral infarction, the medicine of miocardial infarction are treated according to claim 1, it is characterised in that by following weight
The raw material composition of number：
80~105 parts of the Radix Astragali, 10~18 parts of Radix Angelicae Sinensis, 11~18 parts of the radix paeoniae rubrathe, 11~16 parts of earthworm, 9~15 parts of Ligusticum wallichii, bush 11~
18 parts, 9~15 parts of safflower, 11~18 parts of peach kernel, 11~18 parts of the root of fangji, 9~15 parts of cassia seed, 11~18 parts of rhizoma Gastrodiae, the red sage root 15
~28 parts, 10~18 parts of raw bark of eucommia, 10~18 parts of yncaria stem with hooks, 8~14 parts of jujube kernel, 8~15 parts of the seed of Oriental arborvitae.
3. a kind of cerebral infarction, the medicine of miocardial infarction are treated according to claim 2, it is characterised in that by following weight
The raw material composition of number：
95 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of the radix paeoniae rubrathe, 15 parts of earthworm, 12 parts of Ligusticum wallichii, 12 parts of bush, 12 parts of safflower, 12 parts of peach kernel,
12 parts of the root of fangji, 12 parts of cassia seed, 12 parts of rhizoma Gastrodiae, 20 parts of the red sage root, 15 parts of raw bark of eucommia, 15 parts of yncaria stem with hooks, 10 parts of jujube kernel, the seed of Oriental arborvitae 10
Part.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108126117A (en) * | 2018-02-06 | 2018-06-08 | 冯丽华 | A kind of Chinese medicine composition for treating cerebral infarction |
| CN115154510A (en) * | 2022-08-10 | 2022-10-11 | 山东第一医科大学附属省立医院(山东省立医院) | Traditional Chinese medicine composition for treating myocardial infarction and preparation method thereof |
-
2016
- 2016-12-14 CN CN201611221414.2A patent/CN107050311A/en active Pending
Non-Patent Citations (1)
| Title |
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| 陈宝田: "《时方的临床应用》", 28 February 1989, 广东科技出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108126117A (en) * | 2018-02-06 | 2018-06-08 | 冯丽华 | A kind of Chinese medicine composition for treating cerebral infarction |
| CN115154510A (en) * | 2022-08-10 | 2022-10-11 | 山东第一医科大学附属省立医院(山东省立医院) | Traditional Chinese medicine composition for treating myocardial infarction and preparation method thereof |
| CN115154510B (en) * | 2022-08-10 | 2023-04-21 | 山东第一医科大学附属省立医院(山东省立医院) | Traditional Chinese medicine composition for treating myocardial infarction and preparation method thereof |
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Application publication date: 20170818 |