CN106723048B - One kind is for health food for relieving fatigue and preparation method thereof - Google Patents
One kind is for health food for relieving fatigue and preparation method thereof Download PDFInfo
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- CN106723048B CN106723048B CN201710054003.7A CN201710054003A CN106723048B CN 106723048 B CN106723048 B CN 106723048B CN 201710054003 A CN201710054003 A CN 201710054003A CN 106723048 B CN106723048 B CN 106723048B
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- ginseng
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
One kind being used for health food for relieving fatigue, is mixed by ginseng, matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean, is extracted by ginseng ethyl alcohol, obtains thick paste A；Matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are decocted with water, obtain thick paste B；Two parts thick paste A, B are mixed, is dried under reduced pressure, is ground into fine powder.The present invention combines substance in above-mentioned four, from the cooperative effect for the characteristics of tonifying Qi, filling liver kidney, enriching yin, invigorating the spleen, inducing resuscitation, reaching alleviation physical fatigue.Health food provided by the invention can extend the mice burden swimming time, reduce body blood lactase acid area caused by fatigue, reduce the content of urea nitrogen in blood, while increase the autonomic activities number of mouse.
Description
Technical field
It is that using food and can be used for the article of health food as raw material preparation the invention belongs to functional health-care food field
Be used for health food for relieving fatigue.
Background technology
Fatigue is a kind of comprehensive physiology course being related to many Physiology and biochemistry factors, is that human body is mental or physical exertion is arrived
A kind of normal physiological phenomena that certain phase necessarily occurs.It indicates the temporary decline of original ability to work, it may be possible to body
Develop to a tendency of sick and wounded state.Modern medicine thinks that the generation of fatigue accumulates with energy substance consumption, metabolite, is interior
The factor relations such as ambient stable sexual maladjustment, free radical influence are close, and fatigue is broadly divided into physiologic fatigability and pathological fatigue two
Major class.Physiologic fatigability includes 4 kinds of physical fatigue, mental fatigue, psychology (spirit) fatigue and mixing fatigue etc. again.Wherein,
Physical fatigue is called exercise induced fatigue, when human body for a long time, carry out excess load physical exertion when, muscle (skeletal muscle) group
It shrinks persistently or exceedingly, while largely consumption intramuscular energy substance, will produce lactic acid, carbon dioxide, water, serum urine
The metabolites such as plain nitrogen, the acidity in blood can also increase.When these metabolites (be otherwise known as kinotoxin) are in muscle
Gather it is a certain amount of after, so that it may the mobility for interfering muscle cell keeps muscle effectively flexible from continuing, and stimulates
Human tissue cell and cerebral central nervous system.Kinotoxin enters blood and runs whole body, makes one to generate limbs fatigue, be stranded
Tired, DOMS, apocleisis etc. are uncomfortable to be felt, make one to feel that body is tired, fatigue just produces in this way.
Performance one of of the fatigue as sub-health state, is the hot fields of Recent study.Sub-health state is the world
One group of clinical symptoms that health organization (WHO) proposes, between health and disease rim condition, also known as secondary health status, third shape
State, gray states.Bright according to mono- global sex inventory of WHO, the people of 70%-75% is in chronic fatigue syndrome as main table
Existing sub-health state.According to statistics, the U.S. has 6,000,000 people are under a cloud to be in sub-health state every year, and the age is mostly 20-45 year
Between.Developed caused chronic fatigue syndrome by inferior health and waited indefinitely always excessively, is just being paid more and more attention in the U.S. and Japan.China
People in sub-health state accounts for the 60%-70% of country's total population, mostly occurs in 35-45 Sui more than 700,000,000, with mental labor
Dynamic person is in the majority.10 city working clans of the Ministry of Public Health pair, which investigate, to be found, the people in sub-health state accounts for 48% or more.Hunan Province woman
Female federation announces 5000 40~60 years old middle-aged women survey reports and shows that 70% is in sub-health state.Also there is research table
Bright, middle-aged intellectuals of China 60%-70% is in sub-health state, and the 25-35 Sui Proportion of patients rate of climb is surprising at present,
Once 12.6 ten thousand university students of State Education Commission pair carried out inferior health investigation and find that nearly 40% university student is in sub-health state.
Population in sub-health state is in rising trend in many countries and regions, and inferior health, which has become, extremely urgent to be needed to solve
The problem of.
But since doctor trained in Western medicine thinks that sub-health state is not belonging to disease, it is not suitable for being treated with drug, often plain with extra-nutrition,
It rests to relieve fatigue.Theory of traditional Chinese medical science to alleviate physical fatigue have strengthening the spleen and stomach, kidney tonifying, essence replenishing, blood-nourishing tune liver, the tendon and vessel that makes moist,
Aligning reposes, improves the advantage and characteristic of sleep, and Chinese medicine alleviate abundant physical fatigue healthy food material, wide variety,
Being optimal of formula combination can be passed through.
" fatigue " is known as " void ", " consumptive disease ", " deficient " in traditional Chinese medicine,《The Yellow Emperor's Canon of Internal Medicine》In, fatigue more referred to as " tired ",
" solution is fallen ", " tired thin ", " body weight ", " weight " etc..《Plain Questions, which is shown, discusses calmly a piece》In point out that " liver void, kidney deficiency, spleen deficiency, all make us
The tired injustice of weight ", according to the Chinese medicine theory of visceral outward manifestation, fatigue and the five internal organs are all related, main duty in spleen, liver, kidney, also have with the heart, lung
It closes.The dysfunction of the spleen in transport, then no resource of generating and transforming QI and blood, limb muscle cannot support, show as four limbs lassitude hypodynamia, muscle is soft, very
Or flaccidity syndrome with atrophy and debility of the limbs and the body.The spleen has the function to transport and transform nutrients again, and water is wet, the transmitting and distributing the fluids hypofunction of spleen, easily gives birth to wet poly- phlegm, and phlegm wet is tired to be hindered in limb muscle,
It is powerless then to show as the tired weight of limbs, or even miserable pain.Liver storing blood, main reinforcement are " source of endurance " that liver stores blood, and adjusts
Blood volume is saved, can guarantee the normal defeated cloth of blood in motion process.The kidney being the origin of congenital constitution, store essential substances, and main bone gives birth to marrow.It gives up completely to natural impulse, mistake
Degree fatigue, damage of kidney-essence, marrow sea deficiency is then apathetic, dizziness and tinnitus, failure of memory, thought slowness, soreness and weakness of waist and knees, limb
Body impotence is weak not to be had to, fatigue and weak.Physical fatigue is also related with the viscera function of the heart, lung.Heart governing blood and vessels, the motive push systemic blood
It is run in arteries and veins, streamer whole body plays nutrition and moisten effect.Heart storing spirit has and dominates human five internal organs six internal organs, figures and organs
The function of all physiological functions and human body spirit and consciousness thinking activities, including the transporting of spleen, the catharsis of liver, the store essential substances of kidney, stomach it
Receiving, four limbs are bent and stretched, the movement of bone is dominated by the heart.Painstaking effort are sufficient, and the motive is vigorous, and the mind has master, then blood must be capable, blood vessels
Tonneau, vitality are vigorous.Lung governing qi department breathes, and heart promoting circulation of blood is helped towards hundred arteries and veins of remittance.Forced labour is excessive, and gas consumption hinders lung, insufficiency of lung-QI, no
Heart promoting circulation of blood can be helped, then it is stagnant the blood stasis of blood occur, shows as the symptoms such as palpitaition, uncomfortable in chest.Lung is " official of canopy " again, closes skin in body, is
The outermost layer barrier of body, Jin Ligao《Differentiation on endogenous distinguishes that gas is few arrogant》Meaning:" internal injury diet forced labour person, cardiopulmonary it
Gas first damages, and is hindered by heat, and heat was both felt frustrated, and weakness of limbs is with dynamic ... " thus the deficiency of vital energys symptoms such as fatigue is often accompanied by burnout, lazyness is sayed.
The generation of muscle power is using blood, the moon, Tianjin, liquid as material base, using gas, positive function as external manifestation.Generation and the gas of fatigue, blood,
The loss of yin, yang has close relationship.During the motion, in addition, hinder Tianjin consumption liquid, easily cause YIN-fluid being insufficient in sweating Qi Qi, it is seen that
Tired also wasting QI-blood body fluid.In a word, Chinese medicine thinks that fatigue is mainly a variety of causes and leads to spleen, liver, three dirty dysfunction of kidney,
The heart, lung involved negative and positive of qi and blood imbalance and caused by.Clinically, common with asthenic symptoms and syndrome of intermingled deficiency and excess.It is empty mainly with yin, yang,
Based on gas, blood deficiency；Actually the invasion of diseases caused by external factors perverse trend, the obstruction of the circulation of vital energy and the evil heap soil or fertilizer over and around the roots such as phlegm wet, damp and hot are mainly led to by visceral dysfunction
Resistance.
With the continuous improvement of people's living standard and health care consciousness, people increasingly pay attention to antifatigue, anti-fatigue product
Also more and more.However, dazzling anti-fatigue product can not fundamentally solve people's fatigue present situation in the market.It is anti-tired
Labor health products develop to today, and kind is extremely complicated, and antifatigue effect is unsatisfactory.The sales volume now socially generally acknowledged is most
Greatly, it is the red ox vitamin drinks of Hong Niu vitamins Beverage Company Limited production to have the anti-fatigue product of strong font size, is also deposited
The red unsound side effect of drink heavily material is being drunk, according to the report of U.S.'s health and fitness site, 253 grams of red drink heavily material sugar just have 27 grams,
These sugar are easy to be affected to the people infrequently taken exercise and overweight people, do not have complete student crowd also uncomfortable body development
It closes.Therefore, exploitation is a kind of edible safer, and antifatigue effect protrudes, and the anti-fatigue product having no adverse reaction is extremely urgent.
Invention content
The object of the present invention is to provide one kind being used for health food for relieving fatigue, is applied not only to alleviate the people of physical fatigue
Group, while mental fatigue can also be alleviated.Physiologic fatigability is not only physical fatigue, also mental fatigue, psychology (spirit) fatigue
With mixing fatigue, the present invention is screened by a large number of experiments, is preferably gone out available in view of a variety of causing factors of fatigue
Press certain prescription compatibility in the raw material of health food, by increase animal walking weight load, mitigate internal urea nitrogen content,
Reduce lactic acid accumulation, it was confirmed that alleviate the function and effect of physical fatigue；The central nervous excitation of animal can be improved simultaneously, increased
The autonomic activities of animal play the role of alleviating mental fatigue.
To achieve the above object, the present invention provides a kind of for health food for relieving fatigue, it is characterised in that is under
Made of row raw material：
Ginseng 100-500 parts by weight matrimony vine 150-750 parts by weight Rhizoma Atractylodis Macrocephalae 100-500 parts by weight coffee beans 50-250 weights
Measure part
Preferably：200 parts by weight of ginseng, 500 parts by weight of matrimony vine, 300 parts by weight of Rhizoma Atractylodis Macrocephalae, 100 parts by weight of coffee bean
Invention also provides a kind of preparation methods for health food for relieving physical fatigue comprising following step
Suddenly：
(1) ginseng ethyl alcohol extracts, and obtains thick paste A；
(2) matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are decocted with water, obtain thick paste B；
(3) two parts thick paste A, B are mixed, is dried under reduced pressure, is ground into fine powder；
(4) gained fine powder is mixed with magnesium stearate, tablet is made to get for health food for relieving physical fatigue.
Preparation method preferred embodiment is：
(1) ginseng is taken, 70% ethyl alcohol of 5-10 times of ginseng weight is added, heating and refluxing extraction 1-4 times is 1-4 hours each, filter
It crosses, merging filtrate, recycles ethyl alcohol, obtain thick paste A；
(2) matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are taken, the water of 8-15 times of weight is added up, is decocted 1-4 times, it is 0.5-2 hours each, merge
Filtrate obtains thick paste B；
(3) two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C are dried under reduced pressure, and are ground into 100 targeted fine powders, are made
Pharmaceutical composition.
It is auxiliary that required various routines when preparing different dosage forms can be added in the active component that raw material of the present invention is prepared
Material, such as disintegrant, lubricant, adhesive are prepared into any type with conventional method of Chinese medicinal and often use peroral dosage form, such as
Granule, pill, powder, tablet, capsule, oral solution etc..
Selected ginseng is well-known health-care good merchantable brand, sweet in flavor, slight bitter, slightly warm in nature in the present invention.Reinforce vital energy,
Veins takes off admittedly reinforces the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence and other effects.Cure mainly it is physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung
Cough, injury thirst, Heat Diabetes, deficiency of qi and blood, prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng etc..Modern pharmacology effect proves
It strengthens the spleen and stomach with strong help, anti-aging, and tonifying Qi promotes the production of body fluid to quench thirst, and intelligence development is reposed, enhancing memory, antifatigue, antioxygen
Change, resisting stress, it is antitumor, improve immunity of organisms the effects that.The experiment proves that ginsenoside can extend heavy burden mouse power
It exhausts swimming time, reduce blood lactase acid, urea in serum nitrogen content, show that it has mitigation to physical fatigue.Ginseng is oligomeric
Peptide can also extend the walking weight load of mouse, reduce urea in serum nitrogen level, and Ldh Activity mitigates blood lactase acid and contains
Amount increases the deposit of hepatic glycogen, and then resists the energy substance consumption of body when sports type fatigue generates, serum urea nitrogen water
Flat raising, Ldh Activity decline and lactic acid largely accumulation etc..
Rhizoma Atractylodis Macrocephalae, it is sweet in flavor, bitter, warm-natured.There are strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis function.For spleen eating less, abdominal distension
Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability etc..Document is summarized, it is found that Rhizoma Atractylodis Macrocephalae and monomer have more than 20 to plant pharmacological action,
Gastrointestinal function and movement can be adjusted, adjust the work that hydrochloric acid in gastric juice and pepsin, enhancing salivary amylase activity etc. adjust gastrointestinal function
With immunoregulation effect adjusts uterine smooth muscle effect, and also anti-aging, antitumor, anti-mutation, brain protection, kidney is protected, adjusted
Heart physiological function is saved, hypoglycemic, anti-inflammatory, antibacterial, expansion blood vessel, calmness, the effect to nervous system, adjusting Peritoneal Stomata, adjusts and drenches
Bar cell, the effects that inhibiting Adipogenesis, inhibiting metabolism activation enzyme, inhibit TYR enzyme activity, cardiac muscle cell is influenced.
The fruit of Chinese wolfberry, it is sweet in flavor, it is mild-natured.It can nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus,
Impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision.Modern pharmacology effect proves that it has immune enhancing, liver protection, drop blood
The effects that fat, hypoglycemic, antitumor, resisting stress, anti-aging, anti-oxidant, anti-neurotrosis.Polysaccharides is that dog is therein main
Functional component has multiple biological activities：Anti-oxidant, anti-aging alleviates physical fatigue, adjusts blood glucose and blood lipid metabolism, guarantor
Eyesight protecting net film prevents its lesion, protection reproductive system etc..When its alleviation physical fatigue effect shows body strenuous exercise, flesh is fine
Dimension constantly generates active oxygen with slow speed, and active oxygen acts on fribrillin, and then inhibits the sensibility and drop of calcium
Low body strength, while the variation of the indexs such as body flesh/hepatic glycogen, urea and lactic acid is influenced, cause body to generate fatigue and feels.
Matrimony vine and its main component polysaccharides can remove free radical, improve antioxidant ability of organism, reduce body and cause fatigue substances, adjust
Human body energy metabolism is saved, while body body can be improved, and then promotes the recovery of muscle power；Bax protein expressions can be reduced, are adjusted
Bcl-2/Bax ratios inhibit Apoptosis, improve locomitivity.25ml/ (kgd) dosage gavages Ningxia fresh fructus lycii Normal juice
Can be obviously prolonged the mice burden swimming time, improve after mouse movement the content of hepatic glycogen in vivo, reduce blood urea nitrogen (BUN) and
The content of blood lactase acid (LAC)；When gavaging Ningxia fresh fructus lycii Normal juice and only extending mice burden swimming of 16.6ml/ (kgd) dosage
Between, reduce the content of blood lactase acid (LAC), and to the influence difference of internal hepatic glycogen content, blood urea nitrogen (BUN) content without notable
Property meaning.Drinking matrimony vine has reduction blood glucose, promotes gluconeogenesis and liver protection function.
Main component has caffeine, tannic acid, fat, acid fat, volatile fat, protein, sugar, fibre in coffee
Dimension, minerals etc., with dispelling fatigue, relieve the effect of alcohol, promoting urination and removing dampness, relief of constipation, improve liver function, appetizing help food, influence
The effects that mood, also some researches show that the active constituents in coffee to help to alleviate oxidative stress, and caffeic acid can improve muscle
To the producing level of blood glucose, moreover it is possible to promote immune and anti-inflammatory.Foreign study, coffee can reduce heart disease, apoplexy and diabetes
Risk, compared with never coffee for drinking personage, daily 6 glasss of drink or more coffee, mortality risk reduce by 10% and 15% respectively.Together
When can make the probability for suffering from Alzheimer disease reduce by 20%.The people that another studies have shown that is drunk coffee in right amount suffers from a heart complaint risk
20% can be reduced.Its mechanism of action may be the component for existing in coffee component and having positive influences to platelet function, pass through
Blood platelet GPIIbIIIa, CD40L expression is reduced, biologically active pdgf is lowered and achieves the goal.One cross-national study shows and does not draw
With coffee, subject compares, and drink significantly reduces more than 900ml coffee person's multiple sclerosis risks daily, and the nerve of caffeine is protected
Shield and inhibition proinflammatory factor Formation and characteristics may schedule to last potential mechanism.
The present invention combines substance in above-mentioned 4, from the characteristics of tonifying Qi, filling liver kidney, enriching yin, invigorating the spleen, inducing resuscitation,
Reach the cooperative effect for alleviating physical fatigue.Health food provided by the invention can extend the mice burden swimming time, reduce tired
Body blood lactase acid area caused by labor, reduces the content of urea nitrogen in blood, while increasing the autonomic activities number of mouse.
Specific implementation mode
The advantageous effect for inventing the health food (lumber's board joins flake coffee) is expanded on further below by way of test example.
Influence of the test example 1 to the mice burden swimming time
One, test material
1 animal：Kunming mouse：18-21g, female are SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 drugs：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Two, test method and result
Take mouse 30, be randomly divided into 3 groups, respectively blank control group, lumber's board ginseng flake coffee 3.67g raw materials/kg,
1.835g raw material/kg.Give tested material 1 time daily, continuous 30 days, after last is to sample 30min, by the lead of 5% weight of tail portion load
Skin is placed in 25 ± 1 DEG C of sink went swimming, records the death time of animal.Concrete outcome is shown in Table 1.
1 lumber's board of table joins influence of the flake coffee to mice burden swimming time and autonomic activities
Note：With blank group ratio * p ＜ 0.05
1 test result of table ginseng flake coffee 3.67g raw materials/kg groups can extend the swimming time of animal, two equal energy of dosage group
Increase the autonomic activities of animal.
The present invention can increase fatigue of animals endurance, and have certain central excitatory.This is to the Asia in fatigue state
Healthy population is a good health food for relieving fatigue.
Influence of the test example 2 to urea in serum nitrogen content
One, test material
1 animal：Kunming mouse：18-21g, female are SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 drugs：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
3 kits：Urea nitrogen testing cassete：Bioengineering Research Institute's offer, lot number are built up in Nanjing：20160718.
Two, test method and result
Mouse 40 is taken, is randomly divided into 4 groups, respectively blank control group, ginseng flake coffee 3.67g raw materials/kg, 1.835g is former
Material/kg, 0.918g raw material/kg.Give tested material 1 time daily, continuous 30 days, after last is to sample 30min, in the water of 30 DEG C of temperature
It takes a blood sample after not swimming with a load attached to the body 90min, rest 60min, sets 4 DEG C of refrigerator about 3h, 2000pm/min centrifuges 15min after blood clotting, takes
Serum detects the urea nitrogen content in blood with urea nitrogen kit.Concrete outcome is shown in Table 2.
2 lumber's board of table joins influence of the flake coffee to urea nitrogen in mice serum
Note：With blank group ratio * * p ＜ 0.01
Three dosage of the visible ginseng flake coffee of 2 test result of table can be substantially reduced the urea nitrogen content in serum.
Influence of the test example 3 to full blood lactic area
One, test material
1 animal：Kunming mouse：18-21g, female are SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 drugs：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
3 kits：Full blood lactic testing cassete：Bioengineering Research Institute's offer, lot number are built up in Nanjing：20160823.
Two, test method and result
Mouse 48 is taken, 4 groups, respectively blank control group, ginseng flake coffee are randomly divided into：3.67g raw materials/kg, 1.835g
Raw material/kg, 0.918g raw material/kg.Tested material 1 time is given daily, and continuous 30 days, after last is to sample 30min, took a blood sample 50 μ l, is put into
In the protein precipitant of blood lactase acid kit, does not then bear a heavy burden and stop in the water went swimming 10min of 30 DEG C of temperature, take a blood sample 50 μ l,
It is put into the protein precipitant of blood lactase acid kit, after rest 20min, take a blood sample 50 μ l, and the albumen for being put into blood lactase acid kit is heavy
In the agent of shallow lake, Serum lactic acid content is measured according to the method for kit, calculates blood lactase acid area under the curve=1/2 × (preceding blood breast of swimming
0min blood lactase acids value after acid value+swimming) × 10+1/2 × (20min blood lactase acids value after 0min blood lactase acids value+swimming after swimming) ×
20.Concrete outcome is shown in Table 3.
Table 3 joins influence of the flake coffee to full blood lactic area
Note：With blank group ratio * * p ＜ 0.01
3 test result of table is as it can be seen that ginseng flake coffee 1.835g raw materials/kg, 0.918g raw material/kg can be substantially reduced blood lactase acid
Area.
The present invention can increase the mice burden swimming time, reduce the urea nitrogen content in serum, reduce lactic acid face in blood
Product, while increasing autonomic activities, the patient for being suitable for physical fatigue alleviates physical fatigue, mitigates body since fatigue is invited not
Suitable symptom, inspires enthusiasm simultaneously, and resisting fatigue accelerates body recovery.
Test example 3：For prove ginseng flake coffee (ginseng, matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean prescription) have a better effect, to ginseng,
Matrimony vine, Rhizoma Atractylodis Macrocephalae, four kinds of ingredients of coffee bean anti-fatigue effect carried out contrast test.
Test example 4：Influence to mouse anti-reflecting fatigue ability
One, test material
1 animal：Kunming mouse：Female, is purchased from Changchun Institute of Biological Products Co., Ltd., licensing by SPF grades
Number：SCXK (Ji) -2011-0003.
2 test specimens：
The ginseng flake coffee prepared in embodiment is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Ginseng 300g adds 5 times of 70% ethyl alcohol of amount, heating and refluxing extraction 2 times two hours every time, to merge extracting solution and concentrate
To thick paste, thick paste amount 175g is obtained, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Matrimony vine 500g adds 10 times of water to decoct twice, one hour every time, and collecting decoction, filtration is condensed into relative density
1.28-1.30 (60 DEG C) thick pastes are provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Rhizoma Atractylodis Macrocephalae 400g adds 10 times of water to decoct twice, one hour every time, and collecting decoction, filtration is condensed into relative density
1.28-1.30 (60 DEG C) thick pastes are provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Coffee bean 200g adds 10 times of water to decoct twice, one hour every time, and collecting decoction, filtration is condensed into relative density
1.28-1.30 (60 DEG C) thick pastes are provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Two, test method and result
Mouse 64 is taken, 6 groups, respectively blank control group, ginseng flake coffee 2g crude drugs/kg groups, ginseng group are randomly divided into
(20ml/kg), matrimony vine group (20ml/kg), Rhizoma Atractylodis Macrocephalae group (20ml/kg), coffee bean group (20ml/kg).Daily gavage, which is given, to be tested
Sample 1 time, successive administration 30 days.After last gives test specimen 30 minutes, animal is placed in 25 ± 1 DEG C of sink went swimming,
Record the death time of animal.It the results are shown in Table 1
Influence of 1. test specimen of table to mouse swimming time
When test result shows to give test specimen 30 days, ginseng flake coffee group mouse swimming time is with control group than apparent
Increase, that is, there is apparent anti-fatigue ability.
Test example 5 and the swimming endurance of red ox health products have carried out contrast test.
One, test material
1 animal：Kunming mouse：18-21g, female are SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 drugs：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.Red ox vitamin function drink
Stoste is concentrated 20 times, on probation by material, the production of Hong Niu vitamins Beverage Company Limited, supermarket's purchase using preceding.
Two, test method and result
Mouse 30 is taken, is randomly divided into 3 groups, respectively blank control group, lumber's board ginseng flake coffee 3.67g raw materials/kg, red
Ox concentrate 20ml/kg groups.Tested material 1 time is given daily, and continuous 30 days, after last is to sample 30min, animal is placed in 25 ± 1 DEG C
Sink went swimming, record the death time of animal.Concrete outcome is shown in Table 4.
4 lumber's board of table joins flake coffee and influence of the red drink heavily material to mouse swimming time
Note：With blank group ratio * * p ＜ 0.01, the Δ p ＜ 0.05 compared with red ox concentrate
4 test result of table is shown, compared with blank group, when ginseng flake coffee 3.67g raw materials/kg groups can extend the swimming of animal
Between, red ox concentrate has the tendency that extending swimming time；Compared with red ox concentrate 20ml/kg dosage groups, ginseng flake coffee extends
Animal swimming time is nearly 2 times of red ox concentrate.
Embodiment 1
Formula：Ginseng 220g, matrimony vine 550g, Rhizoma Atractylodis Macrocephalae 300g, coffee bean 100g
Prepare total amount：1000 are made, every 0.6g
Instructions of taking：Three times a day, 3 tablets once.
Preparation method：(1) ginseng 220g is taken, 5 times of 70% ethyl alcohol of amount, heating and refluxing extraction 2 times is added 2 hours every time, to filter
It crosses, merging filtrate, recycles ethyl alcohol, be concentrated into 60 DEG C and survey 1.28~1.30 thick paste A of relative density；
(2) matrimony vine 550g, Rhizoma Atractylodis Macrocephalae 300g, coffee bean 100g are taken, 10 times of amount water are added, decoction is secondary, 1 hour every time, merges,
It is concentrated into 60 DEG C of relative densities 1.28~1.30 and surveys thick paste B；
(3) thick paste A, B are mixed, are dried under reduced pressure, are ground into 100 mesh fine powders,
(4) gained fine powder is mixed with the magnesium stearate of fine powder weight 2%, adds 95% alcohol granulation, tabletting, packet film
Clothing is made 1000 to get for health food for relieving physical fatigue.
Embodiment 2
Formula：Ginseng 500g, matrimony vine 750g, Rhizoma Atractylodis Macrocephalae 500g, coffee bean 250g
Preparation method：(1) people is taken to participate in 10 times of 70% ethyl alcohol of amount, heating and refluxing extraction 4 times 4 hours every time, is filtered, closed
And filtrate, ethyl alcohol is recycled, 60 DEG C is concentrated into and surveys 1.28~1.30 thick paste A of relative density；
(2) it takes matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean to add 15 times of amount water, decocts 3 times, 2 hours every time, merge, be concentrated into 60 DEG C relatively
Density 1.28~1.30 surveys thick paste B；
(3) thick paste A, B are mixed, are dried under reduced pressure, are ground into 100 mesh fine powders,
Powder is made according to the customary adjuvant that common process is added pharmaceutically in above-mentioned raw materials medicine.
Embodiment 3
Formula：Ginseng 100g matrimony vine 150g Rhizoma Atractylodis Macrocephalae 100g coffee beans 50g
Preparation method：(1) people is taken to participate in 6 times of 70% ethyl alcohol of amount, heating and refluxing extraction 2 times 3 hours every time, filters, merges
Filtrate recycles ethyl alcohol, is concentrated into 60 DEG C and surveys 1.28~1.30 thick paste A of relative density；
(2) it takes matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean to add 8 times of amount water, decocts 2 times, 1.5 hours every time, merge, be concentrated into 60 DEG C of phases
Thick paste B is surveyed to density 1.28~1.30；
(3) thick paste A, B are mixed, are dried under reduced pressure, are ground into 100 mesh fine powders,
Capsule is made according to the customary adjuvant that common process is added pharmaceutically in above-mentioned raw materials medicine.
Claims (4)
1. one kind being used for health food for relieving fatigue, it is characterised in that be made of following raw materials according：
200 parts by weight of ginseng, 500 parts by weight of matrimony vine, 300 parts by weight of Rhizoma Atractylodis Macrocephalae, 100 parts by weight of coffee bean；
Preparation process is as follows：
(1) ginseng is taken, 70% ethyl alcohol of 5-10 times of ginseng weight is added, heating and refluxing extraction 1-4 times is 1-4 hours each, filtration,
Merging filtrate recycles ethyl alcohol, obtains thick paste A；
(2) matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are taken, the water of 8-15 times of weight is added up, is decocted 1-4 times, it is 0.5-2 hours each, merge filter
Liquid obtains thick paste B；
(3) two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C are dried under reduced pressure, and are ground into 100 targeted fine powders, health care is made
Food.
2. one kind being used for health food for relieving fatigue, it is characterised in that be made of following raw materials according：
Ginseng 220g, matrimony vine 550g, Rhizoma Atractylodis Macrocephalae 300g, coffee bean 100g；
Preparation process is as follows：
(1) ginseng is taken, 70% ethyl alcohol of 5-10 times of ginseng weight is added, heating and refluxing extraction 1-4 times is 1-4 hours each, filtration,
Merging filtrate recycles ethyl alcohol, obtains thick paste A；
(2) matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are taken, the water of 8-15 times of weight is added up, is decocted 1-4 times, it is 0.5-2 hours each, merge filter
Liquid obtains thick paste B；
(3) two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C are dried under reduced pressure, and are ground into 100 targeted fine powders, health care is made
Food.
3. one kind being used for health food for relieving fatigue, it is characterised in that be made of following raw materials according：
Ginseng 500g, matrimony vine 750g, Rhizoma Atractylodis Macrocephalae 500g, coffee bean 250g
Preparation process is as follows：
(1) ginseng is taken, 70% ethyl alcohol of 5-10 times of ginseng weight is added, heating and refluxing extraction 1-4 times is 1-4 hours each, filtration,
Merging filtrate recycles ethyl alcohol, obtains thick paste A；
(2) matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are taken, the water of 8-15 times of weight is added up, is decocted 1-4 times, it is 0.5-2 hours each, merge filter
Liquid obtains thick paste B；
(3) two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C are dried under reduced pressure, and are ground into 100 targeted fine powders, health care is made
Food.
4. one kind being used for health food for relieving fatigue, it is characterised in that be made of following raw materials according：
Ginseng 100g matrimony vine 150g Rhizoma Atractylodis Macrocephalae 100g coffee beans 50g
Preparation process is as follows：
(1) ginseng is taken, 70% ethyl alcohol of 5-10 times of ginseng weight is added, heating and refluxing extraction 1-4 times is 1-4 hours each, filtration,
Merging filtrate recycles ethyl alcohol, obtains thick paste A；
(2) matrimony vine, Rhizoma Atractylodis Macrocephalae, coffee bean are taken, the water of 8-15 times of weight is added up, is decocted 1-4 times, it is 0.5-2 hours each, merge filter
Liquid obtains thick paste B；
(3) two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C are dried under reduced pressure, and are ground into 100 targeted fine powders, health care is made
Food.
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Families Citing this family (3)
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| CN108967864A (en) * | 2018-07-05 | 2018-12-11 | 天津益倍元天然产物技术有限公司 | Improve energy, the functional composition relieved fatigue and its preparation method and application |
| CN110856516A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free coffee functional food and preparation method thereof |
| TWI750489B (en) * | 2019-07-17 | 2021-12-21 | 京冠生物科技股份有限公司 | Use of fermented black soybeans for preparing anti-fatigue medicines |
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| CN1098645C (en) * | 2000-10-23 | 2003-01-15 | 中国人民解放军总后勤部军需装备研究所 | Canned rice gruel with functions of resisting fatigue, resisting oxygen deficit and regulating sleep |
| CN101874537A (en) * | 2009-12-07 | 2010-11-03 | 王杰 | Ginseng powder contained granule |
| CN104784292A (en) * | 2015-03-27 | 2015-07-22 | 孙伟 | Health food for relieving fatigue |
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