CN106723048A - One kind is for health food for relieving fatigue and preparation method thereof - Google Patents
One kind is for health food for relieving fatigue and preparation method thereof Download PDFInfo
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- CN106723048A CN106723048A CN201710054003.7A CN201710054003A CN106723048A CN 106723048 A CN106723048 A CN 106723048A CN 201710054003 A CN201710054003 A CN 201710054003A CN 106723048 A CN106723048 A CN 106723048A
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- fatigue
- thick paste
- ginseng
- health food
- blood
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
One kind is used for health food for relieving fatigue, is mixed by ginseng, matrimony vine, the bighead atractylodes rhizome, coffee bean, is extracted by ginseng ethanol, obtains thick paste A；Matrimony vine, the bighead atractylodes rhizome, coffee bean are boiled with decocting, obtain thick paste B；Two parts thick paste A, B are mixed, drying under reduced pressure is ground into fine powder.Combinations of substances in above-mentioned four together, the characteristics of from tonifying Qi, filling liver kidney, enriching yin, invigorating the spleen, inducing resuscitation, is reached the cooperative effect of alleviation physical fatigue by the present invention.The health food that the present invention is provided can extend the mice burden swimming time, reduce the body blood lactase acid area that fatigue causes, and the content of urea nitrogen in blood be reduced, while increasing the autonomic activities number of times of mouse.
Description
Technical field
It is with food and to can be used for the article of health food be prepared by raw material the invention belongs to functional health-care food field
For health food for relieving fatigue.
Background technology
Fatigue be it is a kind of be related to the comprehensive physiology course of many Physiology and biochemistry factors, be that human body is mental or physical exertion is arrived
A kind of normal physiological phenomena that certain phase necessarily occurs.It indicates the temporary transient decline of original ability to work, it may be possible to body
Develop into a tendency of sick and wounded state.Modern medicine thinks that the generation of fatigue and energy substance are consumed, metabolite is piled up, interior
Closely, fatigue is broadly divided into physiologic fatigability and pathological fatigue two to the factor relations such as ambient stable sexual maladjustment, free radical influence
Major class.Physiologic fatigability is again 4 kinds including physical fatigue, mental fatigue, psychology (spirit) fatigue and mixing fatigue etc..Wherein,
Physical fatigue is called exercise induced fatigue, when human body for a long time, carry out excess load physical exertion when, muscle (skeletal muscle) group
Persistently or exceedingly shrink, while a large amount of consumption intramuscular energy substances, lactic acid, carbon dioxide, water, serum can be produced to urinate
The metabolites such as plain nitrogen, the acidity in blood can also increase.When these metabolites (be otherwise known as kinotoxin) are in muscle
Gather it is a certain amount of after, so that it may hinder the mobility of muscle cell, prevent muscle effective flexible from proceeding, and stimulate
Human tissue cell and cerebral central nervous system.Kinotoxin enters blood and runs whole body, makes one to produce limbs fatigue, is stranded
Tired, DOMS, apocleisis etc. are uncomfortable to be felt, make one to feel that body is tired, so fatigue is just generated.
One of tired performance as sub-health state, is the hot fields of Recent study.Sub-health state is the world
One group of clinical symptoms that health organization (WHO) is proposed, between health and disease rim condition, also known as secondary health status, the 3rd shape
State, gray states.Bright according to mono- global sex inventory of WHO, it is main table that the people of 70%-75% is in chronic fatigue syndrome
Existing sub-health state.According to statistics, the U.S. has 6,000,000 people under a cloud in sub-health state every year, and the age is more 20-45 year
Between.Wait indefinitely by the inferior health chronic fatigue syndrome that causes of development and always excessively, be just increasingly subject to pay attention in the U.S. and Japan.China
People in sub-health state accounts for the 60%-70% of country's total population more than 700,000,000, multiple to be born in 35-45 Sui, with mental labor
Dynamic person is in the majority.The Ministry of Public Health finds that the people in sub-health state accounts for more than 48% to 10 city working clan investigation.Hunan Province woman
Female federation announces 5000 40~60 years old middle-aged women survey reports and shows, 70% is in sub-health state.Also there is research table
Bright, middle-aged intellectuals of China 60%-70% is in sub-health state, and the Proportion of patients rate of climb of current 25-35 Sui is surprising,
Once State Education Commission carried out inferior health investigation discovery to 12.6 ten thousand university students, and nearly 40% university student is in sub-health state.
Population in sub-health state is in rising trend in many countries and regions, inferior health have become it is extremely urgent need solve
Problem.
But because doctor trained in Western medicine thinks that sub-health state is not belonging to disease, be not suitable for being treated with medicine, often with supplement the nutrients element,
Rest carrys out fatigue-relieving.Theory of traditional Chinese medical science to alleviate physical fatigue have strengthening the spleen and stomach, kidney tonifying, essence replenishing, blood-nourishing adjust liver, the tendon and vessel that makes moist,
Advantage and feature that aligning is reposed, improved the health care of sleep, and the traditional Chinese medical science alleviate abundant physical fatigue healthy food material, wide variety,
Can be by being optimal of formula combination.
" fatigue " is referred to as " void ", " consumptive disease ", " deficient " in traditional Chinese medicine,《The Yellow Emperor's Canon of Internal Medicine》In, fatigue many referred to as " tired ",
" solution is fallen ", " tired thin ", " body weight ", " body weight " etc..《Plain Questions is shown and discuss a piece calmly》In point out " it is liver void, kidney deficiency, insufficiency of the spleen, all make us
The tired injustice of body weight ", according to the traditional Chinese medical science theory of visceral outward manifestation, fatigue and the five internal organs are all related, main duty in spleen, liver, kidney, also have with the heart, lung
Close.The dysfunction of the spleen in transport, then no resource of generating and transforming QI and blood, limb muscle cannot moisten foster, show as four limbs lassitude hypodynamia, and muscle is soft, very
Or flaccidity syndrome with atrophy and debility of the limbs and the body.The spleen has the function to transport and transform nutrients again, and water is wet, the transmitting and distributing the fluids hypofunction of spleen, easily gives birth to wet poly- phlegm, and phlegm wet is tired to be hindered in limb muscle,
Then show as the tired weight of limbs powerless, or even miserable pain.Liver storing blood, cage bar, be " source of endurance ", liver storage blood, and adjust
Section blood volume, can guarantee that the normal defeated cloth of blood in motion process.The kidney being the origin of congenital constitution, store essential substances, and main bone gives birth to marrow.Give up completely to natural impulse, mistake
Degree fatigue, damage of kidney-essence, marrow sea deficiency is then One's spirits are drooping, dizziness and tinnitus, failure of memory, thought slowness, soreness and weakness of waist and knees, limb
Body impotence is weak without fatigue and weak.Function of the physical fatigue also with the heart, lung is relevant.Heart governing blood and vessels, the motive promotes systemic blood
Run in arteries and veins, streamer whole body plays nutrition and moisten effect.Heart storing spirit, with dominating human five internal organs six internal organs, body official's key
The function of all physiological functions and human body spirit and consciousness thinking activities, including the catharsis of transporting, liver of spleen, the store essential substances of kidney, stomach it
Received, four limbs are bent and stretched, the motion of bone is dominated by the heart.Painstaking effort are sufficient, and the motive is vigorous, and the mind has master, then blood must be capable, blood vessels
Tonneau, vitality is vigorous.Lung governing qi department is breathed, and heart promoting circulation of blood is helped towards hundred arteries and veins of remittance.Excessively, gas consumption hinders lung, insufficiency of lung-QI, no for forced labour
Heart promoting circulation of blood can be helped, then it is stagnant the blood stasis of blood occur, shows as the symptom such as palpitaition, uncomfortable in chest.Lung is again " official of canopy ", and skin is closed in body, is
The outermost layer barrier of body, Jin Ligao《Differentiation on endogenous distinguishes that gas is few arrogant》Meaning:" internal injury diet forced labour person, cardiopulmonary it
Gas is first damaged, and is hindered by heat, and heat was both felt frustrated, and weakness of limbs is with dynamic ... " thus fatigue is often accompanied by the deficiency of vital energy symptoms such as burnout, lazy speech.
Muscle power generation with blood, the moon, Tianjin, liquid as material base, with gas, sun function as external manifestation.Generation and the gas of fatigue, blood,
The loss of yin, yang has close relationship.In addition, in motion process, Tianjin consumption liquid is hindered in sweating Qi Qi, easily causes YIN-fluid being insufficient, it is seen that
Tired also wasting QI-blood body fluid.In a word, the traditional Chinese medical science thinks that fatigue is mainly a variety of causes and causes spleen, liver, the dirty dysfunction of kidney three,
The heart, lung are caused by negative and positive of qi and blood imbalance is involved.Clinically, it is common with asthenic symptoms and syndrome of intermingled deficiency and excess.It is empty main with yin, yang,
Based on gas, blood deficiency；Actually mainly by visceral dysfunction, the invasion and attack of diseases caused by external factors perverse trend, the obstruction of the circulation of vital energy and the evil heap soil or fertilizer over and around the roots such as phlegm wet, damp and hot are caused
Resistance.
With the continuous improvement of people's living standard and health care consciousness, people increasingly pay attention to antifatigue, anti-fatigue product
Also it is more and more.However, a feast for the eyes anti-fatigue product of in the market can not fundamentally solve people's fatigue present situation.It is anti-tired
Labor health products develop into today, and its kind is extremely numerous and diverse, and antifatigue effect is unsatisfactory.The sales volume now socially generally acknowledged is most
Greatly, there are the red ox vitamin drinks of the anti-fatigue product Shi Hongniu vitamins Beverage Company Limited production of strong font size, also deposit
The red unsound side effect of drink heavily material is being drunk, according to the report of U.S.'s health and fitness site, 253 grams of red drink heavily material sugar just there are 27 grams,
These sugar are easily affected to the people for infrequently taking exercise and overweight people, do not have complete student crowd also uncomfortable for body development
Close.Therefore, develop a kind of edible safer, antifatigue effect is protruded, and the anti-fatigue product having no adverse reaction is extremely urgent.
The content of the invention
It is used for health food for relieving fatigue it is an object of the invention to provide one kind, is applied not only to alleviate the people of physical fatigue
Group, while mental fatigue can also be alleviated.Physiologic fatigability is not only physical fatigue, also mental fatigue, psychology (spirit) fatigue
With mixing fatigue, the present invention consider fatigue various Causing Factors, screened by lot of experiments, preferably go out available
Press certain prescription compatibility in the raw material of health food, by increase animal walking weight load, mitigate internal urea nitrogen content,
Reduce lactic acid to pile up, it was confirmed that alleviate the action effect of physical fatigue；The central nervous excitation of animal can be improved simultaneously, increased
The autonomic activities of animal, plays a part of to alleviate mental fatigue.
To achieve the above object, the present invention provides a kind of for health food for relieving fatigue, it is characterised in that be under
Row raw material is made：
Ginseng 100-500 weight portion matrimony vine 150-750 weight portion bighead atractylodes rhizome 100-500 weight portion coffee beans 50-250 weights
Amount part
Preferably：The weight portion of ginseng 200, the weight portion of matrimony vine 500, the weight portion of the bighead atractylodes rhizome 300, the weight portion of coffee bean 100
Invention also provides a kind of preparation method for health food for relieving physical fatigue, it includes following step
Suddenly：
(1) ginseng ethanol is extracted, and obtains thick paste A；
(2) matrimony vine, the bighead atractylodes rhizome, coffee bean are boiled with decocting, obtain thick paste B；
(3) two parts thick paste A, B are mixed, drying under reduced pressure is ground into fine powder；
(4) gained fine powder is mixed with magnesium stearate, is made tablet, obtained final product for health food for relieving physical fatigue.
Preparation method preferred scheme is：
(1) take ginseng, plus 5-10 times of ginseng weight 70% ethanol, heating and refluxing extraction 1-4 times is each 1-4 hours, filter
Cross, merging filtrate, reclaim ethanol, obtain thick paste A；
(2) matrimony vine, the bighead atractylodes rhizome, coffee bean are taken, the water of 8-15 times of weight is added up, is decocted 1-4 times, it is each 0.5-2 hours, merge
Filtrate, obtains thick paste B；
(3) two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C of drying under reduced pressure is ground into 100 targeted fine powders, is made
Pharmaceutical composition.
The active component that raw material of the present invention is prepared, can add various routines required when preparing different dosage forms auxiliary
Material, such as disintegrant, lubricant, adhesive are prepared into any conventional peroral dosage form with conventional method of Chinese medicinal, such as
Granule, pill, powder, tablet, capsule, oral liquid etc..
Selected ginseng is well-known health-care good merchantable brand, sweet, slight bitter, slightly warm in nature in the present invention.Reinforce vital energy,
Veins takes off admittedly, reinforce the spleen to benefit the lung, blood-nourishing of promoting the production of body fluid, tranquilize the mind and promote the intelligence the effects such as.Cure mainly it is physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung
Cough, injury thirst, Heat Diabetes, deficiency of qi and blood, thin prolonged illness void, insomnia of palpitating with fear, impotence Gong Leng etc..Modern pharmacology effect is proved
It has strong help, anti-aging, strengthens the spleen and stomach, and tonifying Qi is promoted the production of body fluid to quench thirst, and intelligence development is reposed, enhancing memory, antifatigue, antioxygen
The effect such as change, resisting stress, antitumor, raising immunity of organisms.Experiment demonstrates ginsenoside can extend heavy burden mouse power
Exhaust swimming time, reduce blood lactase acid, urea in serum nitrogen content, show that it has mitigation to physical fatigue.Ginseng is oligomeric
Peptide can also extend the walking weight load of mouse, reduce urea in serum nitrogen level, and Ldh Activity mitigates blood lactase acid and contains
Amount, increases the deposit of hepatic glycogen, and then resist energy substance consumption, the serum urea nitrogen water of body when sports type fatigue is produced
Flat rising, Ldh Activity decline and lactic acid largely accumulation etc..
The bighead atractylodes rhizome, it is sweet, bitter, warm in nature.There are strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive function.For spleen eating less, abdominal distension
Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability etc..Document is summarized, it is found that the bighead atractylodes rhizome and monomer have more than 20 to plant pharmacological action,
The work of gastrointestinal function and the regulation gastrointestinal function such as motion, regulation hydrochloric acid in gastric juice and pepsin, enhancing salivary amylase activity can be adjusted
With immunoregulation effect, regulation uterine smooth muscle effect, also anti-aging, antitumor, anti-mutation, brain protection, kidney protection, tune
Section heart physiological function, hypoglycemic, anti-inflammatory, antibacterial, expansion of blood vessels, calmness, the effect to nervous system, regulation Peritoneal Stomata, regulation are drenched
Bar cell, suppress Adipogenesis, suppress metabolism activation enzyme, suppress TYR enzyme activity, on effects such as cardiac muscle cell's influences.
The fruit of Chinese wolfberry, it is sweet, it is mild-natured.Can nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus,
Impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision.Modern pharmacology effect proves that it has immune enhancing, liver protection, drop blood
Fat, hypoglycemic, antitumor, resisting stress, anti-aging, anti-oxidant, anti-neurotrosis etc. are acted on.LBP-X is therein main dog
Functional component, with multiple biological activities：Anti-oxidant, anti-aging, alleviation physical fatigue, regulation blood sugar and blood lipid metabolism, guarantor
Eyesight protecting net film prevents its lesion, protection reproductive system etc..When its alleviation physical fatigue effect shows body strenuous exercise, flesh is fine
Dimension constantly produces active oxygen with slow speed, and active oxygen acts on fribrillin, and then suppresses the sensitiveness of calcium and drop
Low body strength, while influenceing the change of the indexs such as body flesh/hepatic glycogen, urea and lactic acid, causes body to produce fatigue to feel.
Matrimony vine and its main component LBP-X can remove free radical, improve antioxidant ability of organism, reduce body and cause fatigue substances, adjust
Section human body energy metabolism, while body body can be improved, and then promotes the recovery of muscle power；Bax protein expressions can be reduced, is adjusted
Bcl-2/Bax ratios, suppress Apoptosis, improve locomitivity.25ml/ (kgd) dosage gavages Ningxia fresh fructus lycii Normal juice
Can be obviously prolonged the mice burden swimming time, improve after mouse movement the content of hepatic glycogen in vivo, reduce blood urea nitrogen (BUN) and
The content of blood lactase acid (LAC)；When gavaging Ningxia fresh fructus lycii Normal juice and only extending mice burden swimming of 16.6ml/ (kgd) dosage
Between, reduce blood lactase acid (LAC) content, and to internal hepatic glycogen content, blood urea nitrogen (BUN) content influence difference without notable
Property meaning.Drinking matrimony vine has reduction blood sugar, promotes gluconeogenesis and liver protection function.
Main component has caffeine, tannic acid, fat, acid fat, volatile fat, protein, sugar, fibre in coffee
Dimension, mineral matter etc., its have dispelling fatigue, relieve the effect of alcohol, promoting urination and removing dampness, relief of constipation, improve liver function, appetizing help food, influence
Mood etc. is acted on, and also there are some researches show the active component in coffee helps to alleviate oxidative stress, caffeic acid can improve muscle
To the producing level of blood sugar, moreover it is possible to promote immune and anti-inflammatory.Foreign study, coffee can reduce heart disease, apoplexy and diabetes
Risk, compares with never coffee for drinking personage, daily 6 glasss or more coffees of drink, and mortality risk reduces by 10% and 15% respectively.Together
When the probability reduction by 20% that can make to suffer from Alzheimer disease.Another research display, the people for drinking coffee in right amount suffers from a heart complaint risk
20% can be reduced.Its mechanism of action is probably the component for existing in coffee component and having positive influences to platelet function, is passed through
Blood platelet GPIIbIIIa, CD40L expression are reduced, biologically active pdgf is lowered and is achieved the goal.One cross-national study shows, and does not draw
With coffee, subject compares, and drink significantly reduces daily more than 900ml coffee person's multiple sclerosis risks, the nerve guarantor of caffeine
Shield and suppression proinflammatory factor Formation and characteristics may schedule to last potential mechanism.
The present invention by combinations of substances in above-mentioned 4 together, the characteristics of from tonifying Qi, filling liver kidney, enriching yin, invigorating the spleen, inducing resuscitation,
Reach the cooperative effect for alleviating physical fatigue.The health food that the present invention is provided can extend the mice burden swimming time, reduce tired
The body blood lactase acid area that labor causes, reduces the content of urea nitrogen in blood, while increasing the autonomic activities number of times of mouse.
Specific embodiment
The beneficial effect of the invention health food (lumber's board joins flake coffee) is expanded on further below by way of test example.
Influence of the test example 1 to the mice burden swimming time
First, test material
1 animal：Kunming mouse：18-21g, female is SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 medicines：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
2nd, test method and result
Take mouse 30, be randomly divided into 3 groups, respectively blank control group, lumber's board ginseng flake coffee 3.67g raw materials/kg,
1.835g raw materials/kg.Give tested material 1 time daily, continuous 30 days, after last is to sample 30min, by the lead of the body weight of afterbody load 5%
Skin, is placed in 25 ± 1 DEG C of tank went swimming, records the death time of animal.Concrete outcome is shown in Table 1.
The lumber's board of table 1 joins influence of the flake coffee to mice burden swimming time and autonomic activities
Note：With blank group than * p ＜ 0.05
The result of the test of table 1 ginseng flake coffee 3.67g raw materials/kg groups can extend the swimming time of animal, two equal energy of dosage group
Increase the autonomic activities of animal.
The present invention can increase fatigue of animals endurance, and with certain central excitatory.This is to the Asia in fatigue state
Healthy population, is a good health food for relieving fatigue.
Influence of the test example 2 to urea in serum nitrogen content
First, test material
1 animal：Kunming mouse：18-21g, female is SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 medicines：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
3 kits：Urea nitrogen testing cassete：Bioengineering Research Institute's offer, lot number are built up in Nanjing：20160718.
2nd, test method and result
Mouse 40 is taken, 4 groups are randomly divided into, respectively blank control group, ginseng flake coffee 3.67g raw materials/kg, 1.835g is former
Material/kg, 0.918g raw material/kg.Give tested material 1 time daily, continuous 30 days, after last is to sample 30min, in the water of 30 DEG C of temperature
Not swimming with a load attached to the body 90min, takes a blood sample after rest 60min, puts 4 DEG C of refrigerator about 3h, and 2000pm/min centrifugations 15min, takes after blood clotting
Serum, the urea nitrogen content in blood is detected with urea nitrogen kit.Concrete outcome is shown in Table 2.
The lumber's board of table 2 joins influence of the flake coffee to urea nitrogen in mice serum
Note：With blank group than * * p ＜ 0.01
Three dosage of the visible ginseng flake coffee of the result of the test of table 2 can substantially reduce the urea nitrogen content in serum.
Influence of the test example 3 to full blood lactic area
First, test material
1 animal：Kunming mouse：18-21g, female is SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 medicines：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
3 kits：Full blood lactic testing cassete：Bioengineering Research Institute's offer, lot number are built up in Nanjing：20160823.
2nd, test method and result
Mouse 48 is taken, 4 groups, respectively blank control group, ginseng flake coffee are randomly divided into：3.67g raw materials/kg, 1.835g
Raw material/kg, 0.918g raw material/kg.Tested material 1 time is given daily, and continuous 30 days, after last is to sample 30min, took a blood sample 50 μ l, is put into
In the protein precipitant of blood lactase acid kit, then do not bear a heavy burden and stop in the water went swimming 10min of 30 DEG C of temperature, take a blood sample 50 μ l,
It is put into the protein precipitant of blood lactase acid kit, after rest 20min, take a blood sample 50 μ l, and the albumen for being put into blood lactase acid kit sinks
In the agent of shallow lake, Serum lactic acid content is determined according to the method for kit, calculate blood lactase acid TG-AUC=1/2 × (preceding blood breast of swimming
0min blood lactase acids value after acid number+swimming) × 10+1/2 × (20min blood lactase acids value after 0min blood lactase acids value+swimming after swimming) ×
20.Concrete outcome is shown in Table 3.
Table 3 joins influence of the flake coffee to full blood lactic area
Note：With blank group than * * p ＜ 0.01
The result of the test of table 3 is visible, and ginseng flake coffee 1.835g raw materials/kg, 0.918g raw material/kg can substantially reduce blood lactase acid
Area.
The present invention can increase the mice burden swimming time, reduce the urea nitrogen content in serum, reduce lactic acid face in blood
Product, while increasing autonomic activities, the patient for being suitable for physical fatigue alleviates physical fatigue, mitigates body because fatigue is invited not
Suitable symptom, while inspiring enthusiasm, resisting fatigue accelerates body recovery.
Test example 3：For prove ginseng flake coffee (ginseng, matrimony vine, the bighead atractylodes rhizome, coffee bean prescription) have preferable curative effect, to ginseng,
Matrimony vine, the bighead atractylodes rhizome, four kinds of anti-fatigue effects of composition of coffee bean have carried out contrast test.
Test example 4：Influence to mouse anti-reflecting fatigue ability
First, test material
1 animal：Kunming mouse：Female, SPF grades, purchased from Changchun Institute of Biological Products Co., Ltd., licensing
Number：SCXK (Ji) -2011-0003.
2 test specimens：
The ginseng flake coffee prepared in embodiment, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Ginseng 300g, plus 5 times of 70% ethanol of amount, heating and refluxing extraction 2 times two hours every time, merge extract solution and concentrate
To thick paste, thick paste amount 175g is obtained, provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Matrimony vine 500g, plus 10 times of decoctings are boiled twice, one hour every time, collecting decoction, filtration, are condensed into relative density
1.28-1.30 (60 DEG C) thick pastes, are provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Bighead atractylodes rhizome 400g, plus 10 times of decoctings are boiled twice, one hour every time, collecting decoction, filtration, are condensed into relative density
1.28-1.30 (60 DEG C) thick pastes, are provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
Coffee bean 200g, plus 10 times of decoctings are boiled twice, one hour every time, collecting decoction, filtration, are condensed into relative density
1.28-1.30 (60 DEG C) thick pastes, are provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.
2nd, test method and result
Mouse 64 is taken, 6 groups, respectively blank control group, ginseng flake coffee 2g crude drugs/kg groups, ginseng group are randomly divided into
(20ml/kg), matrimony vine group (20ml/kg), bighead atractylodes rhizome group (20ml/kg), coffee bean group (20ml/kg).Daily gavage gives to be tested
Sample 1 time, successive administration 30 days.After last gives test specimen 30 minutes, animal is placed in 25 ± 1 DEG C of tank went swimming,
Record the death time of animal.The results are shown in Table 1
Influence of the test specimen of table 1. to mouse swimming time
Result of the test shows, when giving test specimen 30 days, ginseng flake coffee group mouse swimming time is with control group than obvious
Increase, i.e., with obvious anti-fatigue ability.
Test example 5 has carried out contrast test with the swimming endurance of red ox health products.
First, test material
1 animal：Kunming mouse：18-21g, female is SPF grades, public purchased from Changchun Biological Products Institute's Limited Liability
Department, credit number：SCXK (Ji) -2011-0003.
2 medicines：Lumber's board joins flake coffee, is provided by Jilin Academy of Chinese Medicine Sciences's chemistry room.Red ox vitamin function drink
Stoste is concentrated 20 times, on probation by material, Hong Niu vitamins Beverage Company Limited production, supermarket's purchase using preceding.
2nd, test method and result
Mouse 30 is taken, 3 groups are randomly divided into, respectively blank control group, lumber's board ginseng flake coffee 3.67g raw materials/kg, red
Ox concentrate 20ml/kg groups.Tested material 1 time is given daily, continuous 30 days, after last is to sample 30min, animal is placed in 25 ± 1 DEG C
Tank went swimming, record animal death time.Concrete outcome is shown in Table 4.
The lumber's board of table 4 joins influence of the flake coffee with red drink heavily material to mouse swimming time
Note：With blank group than * * p ＜ 0.01, Δ p ＜ 0.05 are compared with red ox concentrate
The result of the test of table 4 shows, compares with blank group, when ginseng flake coffee 3.67g raw materials/kg groups can extend the swimming of animal
Between, red ox concentrate has the trend of extension swimming time；Compare with red ox concentrate 20ml/kg dosage groups, ginseng flake coffee extension
Animal swimming time is nearly 2 times of red ox concentrate.
Embodiment 1
Formula：Ginseng 220g, matrimony vine 550g, bighead atractylodes rhizome 300g, coffee bean 100g
Prepare total amount：It is made 1000, every 0.6g
Instructions of taking：Three times a day, 3 tablets once.
Preparation method：(1) ginseng 220g, plus 5 times of 70% ethanol of amount, heating and refluxing extraction 2 times, 2 hours every time, filter are taken
Cross, merging filtrate, reclaim ethanol, be concentrated into 60 DEG C and survey the thick paste A of relative density 1.28~1.30；
(2) matrimony vine 550g, bighead atractylodes rhizome 300g, coffee bean 100g, plus 10 times of amount water are taken, decoction is secondary, 1 hour every time, merges,
It is concentrated into 60 DEG C of relative densities 1.28~1.30 and surveys thick paste B；
(3) thick paste A, B are mixed, drying under reduced pressure is ground into 100 mesh fine powders,
(4) gained fine powder is mixed with the magnesium stearate of fine powder weight 2%, plus 95% alcohol granulation, compressing tablet, bag film
Clothing, is made 1000, obtains final product for health food for relieving physical fatigue.
Embodiment 2
Formula：Ginseng 500g, matrimony vine 750g, bighead atractylodes rhizome 500g, coffee bean 250g
Preparation method：(1) take people and participate in 10 times of 70% ethanol of amount, heating and refluxing extraction 4 times, 4 hours every time, filtration, conjunction
And filtrate, ethanol is reclaimed, it is concentrated into 60 DEG C and surveys the thick paste A of relative density 1.28~1.30；
(2) matrimony vine, the bighead atractylodes rhizome, coffee bean plus 15 times of amount water are taken, is decocted 3 times, 2 hours every time, merged, be concentrated into 60 DEG C relatively
Density 1.28~1.30 surveys thick paste B；
(3) thick paste A, B are mixed, drying under reduced pressure is ground into 100 mesh fine powders,
Above-mentioned raw materials medicine adds customary adjuvant to be pharmaceutically made powder according to common process.
Embodiment 3
Formula：Ginseng 100g matrimony vine 150g bighead atractylodes rhizome 100g coffee beans 50g
Preparation method：(1) take people and participate in 6 times of 70% ethanol of amount, heating and refluxing extraction 2 times, 3 hours every time, filtration, merging
Filtrate, reclaims ethanol, is concentrated into 60 DEG C and surveys the thick paste A of relative density 1.28~1.30；
(2) matrimony vine, the bighead atractylodes rhizome, coffee bean plus 8 times of amount water are taken, is decocted 2 times, 1.5 hours every time, merged, be concentrated into 60 DEG C of phases
Thick paste B is surveyed to density 1.28~1.30；
(3) thick paste A, B are mixed, drying under reduced pressure is ground into 100 mesh fine powders,
Above-mentioned raw materials medicine adds customary adjuvant to be pharmaceutically made capsule according to common process.
Claims (4)
1. it is a kind of to be used for health food for relieving fatigue, it is characterised in that to be made up of following raw materials according：
Ginseng 100-500 weight portion matrimony vine 150-750 weight portion bighead atractylodes rhizome 100-500 weight portions
Coffee bean 50-250 weight portions.
2. it is according to claim 1 a kind of for health food for relieving fatigue, it is characterised in that to be by following raw materials according system
Into：The weight portion of ginseng 200, the weight portion of matrimony vine 500, the weight portion of the bighead atractylodes rhizome 300, the weight portion of coffee bean 100.
3. a kind of preparation method for health food for relieving physical fatigue according to claim 1, it is characterised in that
Comprise the following steps：
（1）Ginseng ethanol is extracted, and obtains thick paste A；
（2）Matrimony vine, the bighead atractylodes rhizome, coffee bean are boiled with decocting, obtain thick paste B；
（3）Two parts thick paste A, B are mixed, drying under reduced pressure is ground into fine powder；
（4）Gained fine powder is mixed with magnesium stearate, tablet is made, obtained final product for health food for relieving physical fatigue.
4. a kind of preparation method for health food for relieving physical fatigue according to claim 1, it is characterised in that
Comprise the following steps：
（1）Take ginseng, plus 5-10 times of ginseng weight 70% ethanol, heating and refluxing extraction 1-4 times is each 1-4 hours, and filtration is closed
And filtrate, ethanol is reclaimed, obtain thick paste A；
（2）Matrimony vine, the bighead atractylodes rhizome, coffee bean are taken, the water of 8-15 times of weight is added up, decocted 1-4 times, it is each 0.5-2 hours, merge filter
Liquid, obtains thick paste B；
（3）Two parts thick paste A, B are mixed, 0.08Mpa, 70-85 DEG C of drying under reduced pressure is ground into 100 targeted fine powders, is made medicine
Composition.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108967864A (en) * | 2018-07-05 | 2018-12-11 | 天津益倍元天然产物技术有限公司 | Improve energy, the functional composition relieved fatigue and its preparation method and application |
| CN110856516A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free coffee functional food and preparation method thereof |
| TWI750489B (en) * | 2019-07-17 | 2021-12-21 | 京冠生物科技股份有限公司 | Use of fermented black soybeans for preparing anti-fatigue medicines |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294862A (en) * | 2000-10-23 | 2001-05-16 | 中国人民解放军总后勤部军需装备研究所 | Canned rice gruel with functions of resisting fatigue, resisting oxygen deficit and regulating sleep |
| CN101874537A (en) * | 2009-12-07 | 2010-11-03 | 王杰 | Ginseng powder contained granule |
| CN104784292A (en) * | 2015-03-27 | 2015-07-22 | 孙伟 | Health food for relieving fatigue |
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2017
- 2017-01-24 CN CN201710054003.7A patent/CN106723048B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294862A (en) * | 2000-10-23 | 2001-05-16 | 中国人民解放军总后勤部军需装备研究所 | Canned rice gruel with functions of resisting fatigue, resisting oxygen deficit and regulating sleep |
| CN101874537A (en) * | 2009-12-07 | 2010-11-03 | 王杰 | Ginseng powder contained granule |
| CN104784292A (en) * | 2015-03-27 | 2015-07-22 | 孙伟 | Health food for relieving fatigue |
Non-Patent Citations (1)
| Title |
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| 无: "山楂枸杞白术茶消脂抗疲劳", 《老年生活报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108967864A (en) * | 2018-07-05 | 2018-12-11 | 天津益倍元天然产物技术有限公司 | Improve energy, the functional composition relieved fatigue and its preparation method and application |
| CN110856516A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free coffee functional food and preparation method thereof |
| TWI750489B (en) * | 2019-07-17 | 2021-12-21 | 京冠生物科技股份有限公司 | Use of fermented black soybeans for preparing anti-fatigue medicines |
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| CN106723048B (en) | 2018-09-07 |
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