CN104998252A - Iron-replenishment blood-replenishment oral liquid and preparation method thereof - Google Patents
Iron-replenishment blood-replenishment oral liquid and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an iron-replenishment blood-replenishment oral liquid and a preparation method thereof and aims at solving the problem that an iron replenishment agent is poor in absorption, large in adverse reaction of gastrointestinal tract and poor in taste, and the traditional Chinese medicine is slow in effect of replenishing blood. The oral liquid is prepared from the following raw materials according to weight: 100 to 300g of codonopsis pilosula, 100 to 200g of prepared rehmannia root, 100 to 200g of longan aril, 50 to 150g of Chinese date, 50 to 100g of pericarpium citri reticulatae and 60 to 100g of iron protein succinylate, is improved in taste, quality and effect, has the advantages of high cure rate, low adverse reaction rate, small dose and good bioavailability, and can be used for a long period.
Description
Technical field
The present invention relates to iron supplement hematinic, particularly a kind of iron supplement blood-enriching oral liquid and preparation method thereof.
Background technology
Anemia is a kind of symptom and the biochemical indicator of human body diseases, but not this disease itself.Anemia can cause systemic anoxia, causes body tissue cannot produce enough energy and is difficult to adapt to the needs of physical function, and iron deficiency anemia, the excessive and melt quality of losing blood lacks is all lead anemogenic key factor.Iron deficiency anemia (IDA) is that human body storage iron deficiency causes hemoglobin synthetic quantity to reduce and a kind of anemia of being formed, and asiderosis is the most common food deficiency diseases in countries in the world, is one of deficiency disease that sickness rate is the highest in the world.People's anemia of 1/3 is about had in the world 5,000,000,000 population.And IDA or the bad crowd of melt quality account for 500,000,000, at 4 times that developing country's iron deficiency (ID) incidence rate is developed country, the population of 20% is about had to there is IDA melt quality in China bad, wherein male's iron deficiency anemia sickness rate is 10%, women 20%, anemia of pregnant woman reaches 40%, and child is up to 52%.Iron supplementary is in the market mainly inorganic iron and Organic Iron two kinds, is divided into heme iron and the large class of nonheme iron two by the existence form in human body.These iron supplementary absorption differences, gastrointestinal side effect is large, mouthfeel is poor, and Chinese medicine is enriched blood, onset is slower, just must adhere to for a long time taking and playing blood tonification effect, in order to improve ID, and carry out rationally, effective iron supplement enriches blood, adopt Integrated TCM, the iron supplement blood-supplementing preparation of research a new generation is extremely important.
Summary of the invention
The object of the present invention is to provide a kind of iron supplement blood-enriching oral liquid and preparation method thereof, this oral liquid is easy to carry, dose is little, mouthfeel is good, without intestinal zest, bioavailability is high, be applicable to all kinds of crowd, comprise the iron supplement hematinic of diabetes, pyelonephritis, hypertension and obese people.
The technical scheme that the present invention solves is, by following weighing scale: Radix Codonopsis 100-300g, Radix Rehmanniae Preparata 100-200g, Arillus Longan 100-200g, Fructus Jujubae 50-150g, Pericarpium Citri Reticulatae 50-100g, iron protein succinylate 60-100g make as crude drug, and its preparation method is:
(1) getting the common five tastes crude drug of Radix Codonopsis, Radix Rehmanniae Preparata, Arillus Longan, Pericarpium Citri Reticulatae and Fructus Jujubae puts in extraction pot, add water, be heated to boiling, decoct twice, add five tastes crude drug weight 6-12 water doubly, each decoction 1-2 hour, filters at every turn, merge twice filtrate, being concentrated into 60-80 DEG C of survey relative density is the extractum of 1.20-1.35;
(2) in above-mentioned extractum, add the ethanol of mass concentration 75-95%, alcohol content in the mixed liquor of extractum and ethanol is made to reach 65-75%, at 10 DEG C, precipitate with ethanol 24 hours, filters, obtains filtrate, reclaim ethanol, being concentrated into 50-60 DEG C of survey relative density is the extractum of 1.25-1.40, filters, obtains extractum filtrate;
(3) in above-mentioned extractum filtrate, adding iron protein succinylate, obtain mixture, is the sodium hydroxide solution of 2mol/L by concentration, and adjust pH, to 5.8-6.2,50-60 DEG C of stirring, dissolves, obtains lysate;
(4) in above-mentioned lysate, add dissolving liquid amass 2-4 times of water gaging, stir evenly, be the sodium hydroxide solution of 2mol/L by concentration, adjust pH is to 7.2-7.4, under rotating speed is 15000r/min, centrifugalize obtains clear liquid, clear liquid is 0.1-0.3Mpa at operating pressure, ultrafiltrate temperature 20-50 DEG C, molecular cut off is carry out ultrafiltration under the condition of 40000-80000, obtain ultrafiltrate, add the steviosin of ultrafiltrate volume 0.1% and the dense orange essence of natural spy (commercially available prod: Apple Flavor & Fragrance Group Co., Ltd.) of ultrafiltrate volume 0.4%, stir evenly, to obtain final product.
The present invention compares with existing iron protein succinylate oral solution and iron supplement blood-enriching oral liquid, its mouthfeel, quality and effect are all significantly increased, and cure rate is high, and untoward reaction rate is low, can long-term taking, dose is little, and bioavailability is good, due in formula without sucrose, not only can for general clothes for patients, and the people suffering from diabetes, pyelonephritis, hypertension and obesity also can take, fragrant in taste, child and old people easily take.
Detailed description of the invention
Stop embodiment below in conjunction with practical situation to tool of the present invention to elaborate.
Embodiment 1
The present invention is by following weighing scale: Radix Codonopsis 200g, Radix Rehmanniae Preparata 150g, Arillus Longan 150g, Fructus Jujubae 100g, Pericarpium Citri Reticulatae 75g, iron protein succinylate 80g make as crude drug, and its preparation method is:
(1) getting the common five tastes crude drug of Radix Codonopsis, Radix Rehmanniae Preparata, Arillus Longan, Pericarpium Citri Reticulatae and Fructus Jujubae puts in extraction pot, add the water of five tastes crude drug weight 9 times, be heated to boiling, decoct 1.5 hours, filter, medicinal residues add the water of five tastes crude drug weight 9 times, be heated to boiling, decoct 1.5 hours, filter, merge twice filtrate, being concentrated into 70 DEG C of survey relative densities is the extractum of 1.3;
(2) in above-mentioned extractum, add the ethanol of mass concentration 85%, make alcohol content in the mixed liquor of extractum and ethanol reach 70%, at 10 DEG C, precipitate with ethanol 24 hours, filter, obtain filtrate, reclaim ethanol, being concentrated into 55 DEG C of survey relative densities is the extractum of 1.30, filters, obtains extractum filtrate;
(3) in above-mentioned extractum filtrate, adding iron protein succinylate, obtain mixture, is 2mol/L sodium hydroxide solution by concentration, adjust pH to 6.0,55 DEG C of stirrings, dissolves, obtains lysate;
(4) in above-mentioned lysate, add the long-pending 3 times of water gagings of dissolving liquid, stir evenly, be 2mol/L sodium hydroxide solution by concentration, adjust pH to 7.3, clear liquid is obtained by channel separator centrifugalize under rotating speed is 15000r/min, be transported in the fluid reservoir of hollow-fibre membrane ultrafiltration apparatus through ultrafiltration, operating pressure is 0.1-0.3Mpa, ultrafiltrate temperature 20-50 DEG C, molecular cut off is 40000-80000, obtains ultrafiltrate, adds the steviosin of ultrafiltrate volume 0.1% and the dense orange essence of natural spy of ultrafiltrate volume 0.4%, stir evenly, to obtain final product.
Embodiment 2
The present invention is by following weighing scale: Radix Codonopsis 100g, Radix Rehmanniae Preparata 100g, Arillus Longan 100g, Fructus Jujubae 50g, Pericarpium Citri Reticulatae 50g, iron protein succinylate 60g make as crude drug, and its preparation method is:
(1) getting the common five tastes crude drug of Radix Codonopsis, Radix Rehmanniae Preparata, Arillus Longan, Pericarpium Citri Reticulatae and Fructus Jujubae puts in extraction pot, add the water of five tastes crude drug weight 6 times, be heated to boiling, decoct 1 hour, filter, medicinal residues add the water of five tastes crude drug weight 6 times, be heated to boiling, decoct 1 hour, filter, merge twice filtrate, being concentrated into 60 DEG C of survey relative densities is the extractum of 1.35;
(2) in above-mentioned extractum, add the ethanol of mass concentration 75%, make alcohol content in the mixed liquor of extractum and ethanol reach 65%, at 10 DEG C, precipitate with ethanol 24 hours, filter, obtain filtrate, reclaim ethanol, being concentrated into 50 DEG C of survey relative densities is the extractum of 1.40, filters, obtains extractum filtrate;
(3) in above-mentioned extractum filtrate, adding iron protein succinylate, obtain mixture, is 2mol/L sodium hydroxide solution by concentration, adjust pH to 5.8,50 DEG C of stirrings, dissolves, obtains lysate;
(4) in above-mentioned lysate, add the long-pending 2 times of water gagings of dissolving liquid, stir evenly, be 2mol/L sodium hydroxide solution by concentration, adjust pH to 7.2, clear liquid is obtained by channel separator centrifugalize under rotating speed is 15000r/min, be transported in the fluid reservoir of hollow-fibre membrane ultrafiltration apparatus through ultrafiltration, operating pressure is 0.1-0.3Mpa, ultrafiltrate temperature 20-50 DEG C, molecular cut off is 40000-80000, obtains ultrafiltrate, adds the steviosin of ultrafiltrate volume 0.1% and the dense orange essence of natural spy of ultrafiltrate volume 0.4%, stir evenly, to obtain final product.
Embodiment 3
The present invention is by following weighing scale: Radix Codonopsis 300g, Radix Rehmanniae Preparata 200g, Arillus Longan 200g, Fructus Jujubae 150g, Pericarpium Citri Reticulatae 100g, iron protein succinylate 100g make as crude drug, and its preparation method is:
(1) getting the common five tastes crude drug of Radix Codonopsis, Radix Rehmanniae Preparata, Arillus Longan, Pericarpium Citri Reticulatae and Fructus Jujubae puts in extraction pot, add the water of five tastes crude drug weight 12 times, be heated to boiling, decoct 2 hours, filter, medicinal residues add the water of five tastes crude drug weight 12 times, be heated to boiling, decoct 2 hours, filter, merge twice filtrate, being concentrated into 80 DEG C of survey relative densities is the extractum of 1.20;
(2) in above-mentioned extractum, add the ethanol of mass concentration 95%, make alcohol content in the mixed liquor of extractum and ethanol reach 75%, at 10 DEG C, precipitate with ethanol 24 hours, filter, obtain filtrate, reclaim ethanol, being concentrated into 60 DEG C of survey relative densities is the extractum of 1.25, filters, obtains extractum filtrate;
(3) in above-mentioned extractum filtrate, adding iron protein succinylate, obtain mixture, is 2mol/L sodium hydroxide solution by concentration, adjust pH to 6.2,60 DEG C of stirrings, dissolves, obtains lysate;
(4) in above-mentioned lysate, add the long-pending 4 times of water gagings of dissolving liquid, stir evenly, be 2mol/L sodium hydroxide solution by concentration, adjust pH to 7.4, clear liquid is obtained by channel separator centrifugalize under rotating speed is 15000r/min, be transported in the fluid reservoir of hollow-fibre membrane ultrafiltration apparatus through ultrafiltration, operating pressure is 0.1-0.3Mpa, ultrafiltrate temperature 20-50 DEG C, molecular cut off is 40000-80000, obtains ultrafiltrate, adds the steviosin of ultrafiltrate volume 0.1% and the dense orange essence of natural spy of ultrafiltrate volume 0.4%, stir evenly, to obtain final product.
Embodiment 4
The present invention is by following weighing scale: Radix Codonopsis 300g, Radix Rehmanniae Preparata 100g, Arillus Longan 200g, Fructus Jujubae 150g, Pericarpium Citri Reticulatae 50g, iron protein succinylate 60g make as crude drug, and its preparation method is:
(1) getting the common five tastes crude drug of Radix Codonopsis, Radix Rehmanniae Preparata, Arillus Longan, Pericarpium Citri Reticulatae and Fructus Jujubae puts in extraction pot, add the water of five tastes crude drug weight 6 times, be heated to boiling, decoct 1 hour, filter, medicinal residues add the water of five tastes crude drug weight 9 times, be heated to boiling, decoct 1.5 hours, filter, merge twice filtrate, being concentrated into 80 DEG C of survey relative densities is the extractum of 1.20;
(2) in above-mentioned extractum, add the ethanol of mass concentration 75%, make alcohol content in the mixed liquor of extractum and ethanol reach 75%, at 10 DEG C, precipitate with ethanol 24 hours, filter, obtain filtrate, reclaim ethanol, being concentrated into 60 DEG C of survey relative densities is the extractum of 1.25, filters, obtains extractum filtrate;
(3) in above-mentioned extractum filtrate, adding iron protein succinylate, obtain mixture, is 2mol/L sodium hydroxide solution by concentration, adjust pH to 5.9,60 DEG C of stirrings, dissolves, obtains lysate;
(4) in above-mentioned lysate, add the long-pending 2 times of water gagings of dissolving liquid, stir evenly, be 2mol/L sodium hydroxide solution by concentration, adjust pH to 7.4, clear liquid is obtained by channel separator centrifugalize under rotating speed is 15000r/min, be transported in the fluid reservoir of hollow-fibre membrane ultrafiltration apparatus through ultrafiltration, operating pressure is 0.1-0.3Mpa, ultrafiltrate temperature 20-50 DEG C, molecular cut off is 40000-80000, obtains ultrafiltrate, adds the steviosin of ultrafiltrate volume 0.1% and the dense orange essence of natural spy of ultrafiltrate volume 0.4%, stir evenly, to obtain final product.
In said medicine:
Radix Codonopsis: sweet is flat.Return spleen, lung meridian.Spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.
Pharmacological research shows, Radix Codonopsis has following effect:
1, antiulcer action: Radix Codonopsis water decoction-alcohol sedimentation liquid is to all having preventive and therapeutic action by Experimental Gastric Ucler caused by type, pyloric ligation ulcers, indometacin or aspirin.
The mechanism of Radix Codonopsis antiulcer action: 1) gastric acid secretion inhibiting, reduces gastric acidity; 2) promote the secretion of stomach mucus, strengthen stomach mucus-bicarbonate barrier; 3) endogenous prostaglandin (PGEZ) content gastric mucosa being had to protective effect is increased.
2, gastrointestinal motility function is adjusted: Radix Codonopsis is the key medicine of invigorating the spleen and replenishing QI, can correct the gastrointestinal motility dysfunction of pathological state.
3, heart tonifying, shock: Radix Codonopsis has enhancing myocardial contraction, increases cardiac output, antishock effect.
4, Radix Codonopsis can improve the resistivity of body to destructive stimulus.
5, Radix Codonopsis can strengthen hemopoietic function.
6, Radix Codonopsis extract can strengthen the ability that peritoneal macrophage engulfs chicken red blood cell.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Enrich blood YIN nourishing, beneficial essence fills out marrow.For blood deficiency and yellow complexion, cardiopalmus severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, dizzy, tinnitus, and jaw is sent out early white.
Pharmacological research shows, Radix Rehmanniae Preparata has following effect:
1. on the impact of medulla hematopoietic system: Radix Rehmanniae Preparata water decoction gavages every 0.5g to posthemorrhagic anemia mice, every day 1 time, continuous 10 days, the recovery of anemia animal erythrocyte, hemoglobin can be promoted, accelerate propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E).
2. on the impact of blood coagulation: Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis stove and simple necrosis.To the hyperlipemia that high lipid food causes, the hepatic vein hemorrhage that fatty liver and rat endotoxin cause, all has the effect of inhibition thrombosis.Thinking activation to plasminogen, is antithrombotic mechanism of action.
3. on immune impact: Radix Rehmanniae Preparata alcohol extract, to mouse gavaging, has significant protective effect to the macrophage function suppressed by carrageenin; Antagonist forms cell inhibitory action.
4., on the impact of cardiovascular system: wine Radix Rehmanniae Preparata and cook Radix Rehmanniae and have significant hypotensive effect, systolic pressure and diastolic pressure all significantly decline.
5. antioxidation.
6. other effects: give rat with trilute (T3) and cause yin-deficient model and give Radix Rehmanniae Preparata water decoction 3ml (70% concentration) gavage, totally 6 days, the body weight of hyperthyroidism type deficiency of YIN rat is changed, 24 hours amounts of drinking water and urine volume, blood plasma T3, thyroxine (T4) and aldosterone (AD) concentration are significantly improved, namely T3 concentration reduces, T4 concentration raises, and be tending towards normal, illustrate that Radix Rehmanniae Preparata can not only improve deficiency of YIN symptom, and the thyroxin state of energy dysregulation.
Arillus Longan: sweet, temperature.GUIXIN, spleen channel.Spleen reinforcing heart spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Pharmacological research shows, Arillus Longan has following effect:
1. anti-stress effect: Arillus Longan extracting solution is useful to enhancing development, health invigorating, has obvious anti-stress effect.
2. anti-aging effects: Arillus Longan extracting solution has certain free radical resisting and improves the effect of cellular immune function.Found by vitro tests, longan polysaccharide has the effect of scavenging capacity oxygen-derived free radicals, but the effect suppressing hepatomicrosome lipid peroxide is Bipolar, in range of doses, along with the increase lipoid peroxidization resistant of Arillus Longan dosage strengthens, weaken on the contrary when dosage acquires a certain degree, there is no difference until return to matched group.
3. angst resistance effect: Arillus Longan has obvious angst resistance effect.Medical science | education network search arranges
4. pair Inner excretory system effect: research finds, the ethanol extraction of Arillus Longan no matter dosage size, all obviously can reduce the content of prolactin antagonist in female rats serum, and estradiol and testosterone are only just significantly reduced when heavy dose, but obviously can increase the content of progesterone and follicle stimulating hormone, and on interstitialcellstimulating hormone (ICSH) without impact.This obviously reduces for milk when clinical puerpera eats larger dose Arillus Longan puerperal, and recover of uterus is bad, losing blood morely provides theoretical foundation.
Fructus Jujubae: sweet, temperature.Return spleen, stomach, heart channel.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Pharmacological research shows, Fructus Jujubae has following effect:
1. immunosuppressive action: the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, display Fructus Jujubae has same immunosuppressive action with azathioprine, can suppress the generation of antibody to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and does not produce inhibitory action to non-reacted antibody.
2. other effects: the two glucoside A of the flavone in Fructus Jujubae, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and Fructus Jujubae has the effect increasing cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.The swimming time of mice can be extended.Nearest report Fructus Jujubae has the proliferation function of anticancer.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return spleen, stomach warp.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Pharmacological research shows, Pericarpium Citri Reticulatae has following effect:
1. the effect of pair digestive system: volatile oil contained by Pericarpium Citri Reticulatae, has gentle stimulation to gastrointestinal tract, can the secretion of facilitating digestion liquid, gets rid of pneumatosis in intestinal tube, shows the effectiveness of fragrant stomach invigorating and the wind dispelling therapeutic method to keep the adverse QI flowing downwards.
2. the effect of pair cardiovascular system: Pericarpium Citri Reticulatae decoct, ethanol extract etc. can be excited myocardium, but occur on the contrary when dosage is excessive suppressing.In addition, it also can make blood vessel produce slight contraction, rapid raising blood pressure.Pectin in Pericarpium Citri Reticulatae also has certain preventive effect to the arteriosclerosis that high fat diet causes.
3. the effect of pair respiratory system: the irritant passive phlegm-dispelling functions of volatile oil contained by Pericarpium Citri Reticulatae, makes sputum easily bring up.Pericarpium Citri Reticulatae decoct has faint dilating effect to bronchus.The relievining asthma of its ethanol extract is tired higher.
4. the effect of pair genitourinary system: Pericarpium Citri Reticulatae decoct can make Renal vascular shrink, and makes hypourocrinia.
5. antiinflammatory action: Pericarpium Citri Reticulatae decoct and vitamin C, vitamin K use, can strengthen antiinflammation.
The present invention compares with existing iron protein succinylate oral solution, and its mouthfeel, quality and effect are all significantly increased, and pertinent clinical data is as follows:
One, case selection
Select 318 examples to be diagnosed as iron deficiency anemia and obtain informed consent patient carry out this observation of curative effect.Be divided into treatment group 225 example at random, wherein male 129 example, women 96 example; Age 24-65 year, matched group totally 93 example, wherein male 57 example, women 36 example, age 23-63 year.The Hb level of all patients, all lower than 120g/L, meets the diagnostic criteria about anemia in WHO.The mean age of two groups of patients, M-F, the clinical data no significant differences such as the state of an illness, have comparability.
Two, Therapeutic Method
1. matched group is taken merely Philips's (iron protein succinylate oral solution, the large pharmaceutical factory of Italian general mark produces, and 15ml/ props up, every day 2 times, each 1, bfore meals) and is serve on 2 weeks.Treat that Hemoglobin Value is normal, Anemia every day 1 time, each one, serve on 4 weeks after correcting.
2. the iron supplement blood-enriching oral liquid prepared of the oral the present invention for the treatment of group, every day 1 time, each 7-9ml, serve on 2 weeks, treats that Hemoglobin Value is normal, after Anemia is corrected, following the service 4 weeks.
Three, criterion of therapeutical effect
Cure: clinical symptoms is obviously improved.Male: Hb>120g/L, RBC>4 × 10
12/ L, women: Hb>110g/L, RBC>3.5 × 10
12/ L.Take a turn for the better: at least rise before within 8 weeks, interior Hb comparatively treats 20g/L.Invalid: not reach above-mentioned standard.
Four, statistical procedures
Two groups of therapeutic effect compare in table 1
| Group | Number of cases | Cure | Take a turn for the better | Invalid | Effective percentage (%) |
| Treatment group | 225 | 195 | 24 | 6 | 97.3％ |
| Matched group | 93 | 45 | 12 | 36 | 61.3％ |
As can be seen from Table 1, iron supplement blood-enriching oral liquid of the present invention is adopted significantly can to improve patient's iron deficiency anemia situation.
Two groups of anemia experimental index are observed, and the results are shown in Table 2
Compare with before treatment: * P<0.05
As can be seen from Table 2, iron supplement blood-enriching oral liquid of the present invention is adopted significantly can to improve lab index RBC, Hb, HCT of anemia.
Five, two groups of adverse reactions of patients situation occurreds compare, and the results are shown in Table 3.
| Group | Number of cases | Diarrhoea | Spastic colon | Nausea and vomiting | Epigastrium pain | Fraction defective |
| Treatment group | 225 | 0 | 0 | 3 | 0 | 1.3％ |
| Matched group | 93 | 3 | 0 | 6 | 3 | 12.9％ |
As can be seen from Table 3, iron supplement blood-enriching oral liquid provided by the invention untoward reaction is few, is the compound preparation that a kind of good iron supplement is enriched blood.
Conclusion: iron protein succinylate is a peptide species albuminoid iron supplementary; take casein as raw material, to the amino on casein with succinic anhydride acylation modification after, the site that albumen can be combined with ferrum is increased; albumen after acidylate again with ferric iron chelating, obtained iron protein succinylate.Iron protein succinylate not by stomach acids destroy stomach function regulating protease hydrolyzed, does not cause damage to gastric mucosa by the protection of albuminous coat.After entering intestinal, again dissolve, and digest by trypsin.After protein protection film is digested, ferrum starts release in duodenum.Have research display, iron protein succinylate is very beneficial for being absorbed by body, does not but form high absworption peak.It presents is a kind of constant absorption trend in pharmacokinetics research display, reaches the best stable state absorbing and store gradually, can not produce the problem of resistance of the intestines and stomach at each position of body.The gas of compatibility Chinese medicine Radix Codonopsis spleen reinforcing lung, as a means of the source of hemopoietic; Arillus Longan reinforcing the heart spleen, replenishing QI and blood, reinforcing the heart spleen two gas; Radix Rehmanniae Preparata nourishing the blood and yin, vital essence replenishing and marrow benifiting; The Pericarpium Citri Reticulatae that assistant circulation of qi promoting is amusing, strengthens the digestive and absorptive functions of taste, thus reaches the object of tonify without causing stagnation; Fructus Jujubae nourishing blood to tranquillize the mind, relaxes the property of medicine of many medicines, not only determined curative effect, and does not have toxic and side effects, can also take into account QI invigorating when enriching blood, and accomplishes " qi and blood tonifying, treating both the principal and secondary aspects of a disease ".Sucrose is replaced with steviosin in the present invention, not only can for general clothes for patients, and also the people suffering from diabetes, pyelonephritis, hypertension and obesity also can take.Steviosin is used to reduce production cost.Use the seasoning of natural spy dense orange essence, fragrant in taste nature, is particularly suitable for child and old people takes.
In sum, iron supplement blood-enriching oral liquid of the present invention in cure rate and effective percentage apparently higher than general proteins ferric succinate oral administration solution.The untoward reaction rate of iron supplement blood-enriching oral liquid of the present invention is used to be starkly lower than plain edition iron protein succinylate oral solution.And the unsuitable long-term taking of iron protein succinylate oral solution.Iron supplement blood-enriching oral liquid dose of the present invention is little, and bioavailability is good, improves clinical efficacy.There is wide market prospect, have huge economic benefit and social benefit.
Claims (5)
1. an iron supplement blood-enriching oral liquid, is characterized in that, by following weighing scale: Radix Codonopsis 100-300g, Radix Rehmanniae Preparata 100-200g, Arillus Longan 100-200g, Fructus Jujubae 50-150g, Pericarpium Citri Reticulatae 50-100g, iron protein succinylate 60-100g make as crude drug.
2. iron supplement blood-enriching oral liquid according to claim 1, is characterized in that, by following weighing scale: Radix Codonopsis 200g, Radix Rehmanniae Preparata 150g, Arillus Longan 150g, Fructus Jujubae 100g, Pericarpium Citri Reticulatae 75g, iron protein succinylate 80g make as crude drug.
3. iron supplement blood-enriching oral liquid according to claim 1, is characterized in that, by following weighing scale: Radix Codonopsis 100g, Radix Rehmanniae Preparata 100g, Arillus Longan 100g, Fructus Jujubae 50g, Pericarpium Citri Reticulatae 50g, iron protein succinylate 60g make as crude drug.
4. iron supplement blood-enriching oral liquid according to claim 1, is characterized in that, by following weighing scale: Radix Codonopsis 300g, Radix Rehmanniae Preparata 200g, Arillus Longan 200g, Fructus Jujubae 150g, Pericarpium Citri Reticulatae 100g, iron protein succinylate 100g make as crude drug.
5. the preparation method of the iron supplement blood-enriching oral liquid described in claim 1-4 any one, is characterized in that,
(1) getting the common five tastes crude drug of Radix Codonopsis, Radix Rehmanniae Preparata, Arillus Longan, Pericarpium Citri Reticulatae and Fructus Jujubae puts in extraction pot, add water, be heated to boiling, decoct twice, add five tastes crude drug weight 6-12 water doubly, each decoction 1-2 hour, filters at every turn, merge twice filtrate, being concentrated into 60-80 DEG C of survey relative density is the extractum of 1.20-1.35;
(2) in above-mentioned extractum, add the ethanol of mass concentration 75-95%, alcohol content in the mixed liquor of extractum and ethanol is made to reach 65-75%, at 10 DEG C, precipitate with ethanol 24 hours, filters, obtains filtrate, reclaim ethanol, being concentrated into 50-60 DEG C of survey relative density is the extractum of 1.25-1.40, filters, obtains extractum filtrate;
(3) in above-mentioned extractum filtrate, adding iron protein succinylate, obtain mixture, is 2mol/L sodium hydroxide solution by concentration, and adjust pH, to 5.8-6.2,50-60 DEG C of stirring, dissolves, obtains lysate;
(4) in above-mentioned lysate, add dissolving liquid amass 2-4 times of water gaging, stir evenly, be 2mol/L sodium hydroxide solution by concentration, adjust pH is to 7.2-7.4, under rotating speed is 15000r/min, centrifugalize obtains clear liquid, clear liquid is 0.1-0.3Mpa at operating pressure, ultrafiltrate temperature 20-50 DEG C, and molecular cut off is carry out ultrafiltration under the condition of 40000-80000, obtain ultrafiltrate, add the steviosin of ultrafiltrate volume 0.1% and the dense orange essence of natural spy of ultrafiltrate volume 0.4% in ultrafiltrate, stir evenly, to obtain final product.
Priority Applications (1)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109645368A (en) * | 2018-12-28 | 2019-04-19 | 陕西师范大学 | A kind of iron-containing steamed meat product of richness |
| CN112205624A (en) * | 2020-10-28 | 2021-01-12 | 江苏瑞丰医药有限公司 | Ferric pyrophosphate |
| CN112205625A (en) * | 2020-10-28 | 2021-01-12 | 江苏瑞丰医药有限公司 | Ferric pyrophosphate and production method thereof |
| CN112220047A (en) * | 2020-10-28 | 2021-01-15 | 江苏海创知识产权服务有限公司 | Ferric pyrophosphate and production process thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911326A (en) * | 2006-08-16 | 2007-02-14 | 任世斌 | Oral medicine contg. donkey-hide gelatin and iron, and its prepn. method |
| CN104161896A (en) * | 2014-08-16 | 2014-11-26 | 赵学科 | Medicine composition for treating anemia |
| CN104523586A (en) * | 2014-12-29 | 2015-04-22 | 广州瑞尔医药科技有限公司 | Oral liquid and preparing method of oral liquid |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911326A (en) * | 2006-08-16 | 2007-02-14 | 任世斌 | Oral medicine contg. donkey-hide gelatin and iron, and its prepn. method |
| CN104161896A (en) * | 2014-08-16 | 2014-11-26 | 赵学科 | Medicine composition for treating anemia |
| CN104523586A (en) * | 2014-12-29 | 2015-04-22 | 广州瑞尔医药科技有限公司 | Oral liquid and preparing method of oral liquid |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109645368A (en) * | 2018-12-28 | 2019-04-19 | 陕西师范大学 | A kind of iron-containing steamed meat product of richness |
| CN112205624A (en) * | 2020-10-28 | 2021-01-12 | 江苏瑞丰医药有限公司 | Ferric pyrophosphate |
| CN112205625A (en) * | 2020-10-28 | 2021-01-12 | 江苏瑞丰医药有限公司 | Ferric pyrophosphate and production method thereof |
| CN112220047A (en) * | 2020-10-28 | 2021-01-15 | 江苏海创知识产权服务有限公司 | Ferric pyrophosphate and production process thereof |
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| CN104998252B (en) | 2018-04-06 |
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