CN102335387B - Traditional Chinese medicine composition for treating liver stagnation, improving appetite and promoting digestion and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating liver stagnation, improving appetite and promoting digestion and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional chinses medicine composition for treating liver stagnation, improving appetite and promoting digestion and a preparation method thereof, and belongs to the field of traditional Chinese medicine modernization. Active components of the traditional Chinese medicine composition for treating liver stagnation, improving appetite and promoting digestion are prepared by the following raw materials of: by weight, 150 parts of Cyperus Rotundus L (processed by vinegar), 35 parts of corydalis tuber (processed by vinegar), 50 parts of bitter organe (fried with bran), 35 parts of santal, 35 parts of banksia rose, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of radix bupleuri, 75 parts of magnolia cortex ( processed by ginger), 35 parts of clove, 35 parts of aquilaria wood, 25 parts of galagal rhizome, 35 parts of green tangerine peel (processed by vinegar), 100 parts of dried orange peel, 35 parts of licorice, 35 parts of cardamom, 25 parts of curcuma rhizome (processed by vinegar), 35 parts of Villous Amomum Fruit and 15 parts of Chinese cassia tree. The invention has the following advantages: the quality is stable and controllable; the curative effect of the traditional Chinese medicine composition provided by the invention is remarkably raised in comparison with that of present commercial dosage forms; patient dose is minimized; the bioavailability is raised; and the traditional Chinese medicine composition provided by the invention has substantial economical and social benefits.
Description
Technical field
The present invention relates to that a kind of soothing liver-QIization is strongly fragrant, the Chinese medicine composition of appetite-stimulating indigestion-relieving and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Piao's precipitation strongly fragrant ball is the Chinese medicine of the at present commercially available strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization, and it is made by Rhizoma Cyperi (vinegar system), Rhizoma Corydalis (vinegar system), Fructus Aurantii (parched with bran), Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Radix Bupleuri, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae Viride (vinegar system), Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Fructus Amomi Rotundus, Rhizoma Curcumae (vinegar system), Fructus Amomi, Cortex Cinnamomi.But Piao's precipitation strongly fragrant ball soothing liver-QI, change strongly fragrant, whet the appetite, help digestion.Be used for distension and fullness of the chest and abdomen, dyspepsia, vomiting is felt sick, and stops eating and cuts off the water, and the stagnation of QI is gloomy, the gastral cavilty twinge.Rhizoma Cyperi soothing liver-QI for relieving depression in the side, regulating QI to relieve pain, the circulation of qi promoting of Cortex Magnoliae Officinalis row dampness, alleviating distention in middle-JIAO closes with the soothing liver-QI stomach function regulating except full, and the therapeutic method to keep the adverse QI flowing downwards is except full. be monarch drug.The Radix Aucklandiae, Fructus Aurantii, Lignum Santali Albi, Pericarpium Citri Reticulatae regulating qi-flowing for harmonizing stomach, pain relieving in accent, Lignum Aquilariae Resinatum, Radix Bupleuri, Pericarpium Citri Reticulatae Viride dispersing the stagnated live-QI to relieve the stagnation of QI, stopping nausea and vomiting by lowering the adverse flow of QI is ministerial drug altogether.Rhizoma Corydalis, Rhizoma Wenyujin Concisum, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, Flos Caryophylli, Rhizoma Alpiniae Officinarum, the pain relieving of Cortex Cinnamomi warming spleen and stomach for dispelling cold, Fructus Amomi Rotundus, Fructus Amomi removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting is adjuvant drug.The Radix Glycyrrhizae mediation property of medicine is for making medicine.Full side's compatibility is received dispersing the stagnated live-QI to relieve the stagnation of QI altogether, opens the merit that helmet helps digestion.Clinical in hypochondriac pain, feelings will is not smooth, and liver is lost bar and reaches, and two side of body distensions that vapour lock is coerced due to network are altered pain, increase and decrease with the change of feelings will.Sighing frequently uncomfortable in chest, thin fur, stringy pulse; Chronic hepatitis, cholecystitis are seen above-mentioned patient.Stomachache, not catharsis of liver, gastral cavilty is had a pain due to horizontal criminal's taste, abnormal ascending-descending of QI, and pain connects two sides of body, and belch is done frequently, and noisy acid regurgitation defecate not smooth, anorexia, tongue is greasy in vain, and stringy pulse delays; Digestive tract ulcer, chronic gastritis are seen above-mentioned patient.Singultus, depressed angry, irritability is taken advantage of stomach, due to the gastric qi upper punch singultus repeatedly, fullness in the chest and hypochondrium is vexed, the time have nauseating, inappetence, greasy and thin fur, stringy pulse is slow; Gastrointestinal function of nervous system disease is seen above-mentioned patient.
In current high-tech, fast pace, society with keen competition, although material life is very abundant, psychentonia, anxiety ubiquity.These Nervous and Mental Factors are usually the reasons of morbidity.Except speech therapy, Chinese traditional treatment feelings will is hindered the disease that causes a lot of methods, and the most frequently used is the dispersing the stagnated live-QI to relieve the stagnation of QI method.
Theory of Chinese medical science thinks, long-term psychentonia, pessimal stimulation, depressed uneasiness all can cause depression of liver-QI.Stagnation of liver-QI is not dredged, and various symptoms can appear in functional activity of QI being not smooth, and often follows the abnormal of the mental status.Treating different diseases with the same therapeutic principle, in medical dispersing the stagnated live-QI to relieve the stagnation of QI method can treat multiple various disease.
Prescription and the method for making of the strongly fragrant ball of Piao's precipitation are: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g.With 18 flavor medical materials, be ground into fine powder, sieve, mixing.Every 100g powder adds refined honey 160～180g and makes big honeyed pills, and get final product.
This medicine method for making is simple, evident in efficacy.But former prescription type is honeyed pill, easily goes mouldy and microbiological contamination, and is unfavorable for quality control.Take and carry inconvenience, mouthfeel is not good, and every ball weighs 9 grams, and every dose of dose is excessive, and children's, old man and pharyngolaryngitis patient dysphagia are taken inconvenience, and patient's acceptance level is poor.And from oral slow to the gastrointestinal absorption process.These factors directly affect the application clinically of the strongly fragrant ball of plain precipitation, and these factors have affected this medicine applying clinically.
Summary of the invention
First technical problem that the present invention will solve is to provide the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization.
Another technical problem that the present invention will solve is to provide the preparation method of said medicine.
For achieving the above object, the present invention is by the following technical solutions:
The Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization, its active component is made by the raw material of following parts by weight: 150 parts of Rhizoma Cyperis (vinegar system), 35 parts of Rhizoma Corydalis (vinegar system), 50 parts of Fructus Aurantiis (parched with bran), 35 parts, Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts, Pericarpium Citri Reticulatae Viride (vinegar system), 100 parts of Pericarpium Citri Reticulataes, 35 parts, Radix Glycyrrhizae, 35 parts, Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (vinegar system), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials: Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; All the other flavour of a drug water extractions, concentrated, drying obtains dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Dry thing II is the active component of medicine of the present invention.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; All the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03-1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; All the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; All the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of soothing liver-QIization is strongly fragrant, the preparation method of the Chinese medicine composition of appetite-stimulating indigestion-relieving, takes 150 parts of Rhizoma Cyperis (vinegar system), 35 parts of Rhizoma Corydalis (vinegar system), 50 parts of Fructus Aurantiis (parched with bran), 35 parts, Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts, Pericarpium Citri Reticulatae Viride (vinegar system), 100 parts of Pericarpium Citri Reticulataes, 35 parts, Radix Glycyrrhizae, 35 parts, Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (vinegar system), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03-1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.
In described medical material, Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.
In described medical material, Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, and obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.
The Chinese medicine composition that technical solution of the present invention is related and preparation thereof have all that good soothing liver-QIization is strongly fragrant, the appetite-stimulating indigestion-relieving effect.Can be used for treating distension and fullness of the chest and abdomen, dyspepsia, vomiting is felt sick, and stops eating and cuts off the water, and the stagnation of QI is gloomy, the gastral cavilty twinge.By zoopery, we unexpectedly find, the pharmaceutical composition of technique preparation of the present invention is compared with former dosage form, has excellent promotion gastrointestinal motility effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 413 grams of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 1500g, Rhizoma Corydalis (vinegar system) 350g, Fructus Aurantii (parched with bran) 500g, Lignum Santali Albi 350g, Radix Aucklandiae 350g, Rhizoma Wenyujin Concisum 150g, Radix Bupleuri 350g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 750g, Flos Caryophylli 350g, Lignum Aquilariae Resinatum 350g, Rhizoma Alpiniae Officinarum 250g, Pericarpium Citri Reticulatae Viride (vinegar system) 350g, Pericarpium Citri Reticulatae 1000g, Radix Glycyrrhizae 350g, Fructus Amomi Rotundus 350g, Rhizoma Curcumae (vinegar system) 250g, Fructus Amomi 350g, Cortex Cinnamomi 150g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 3 times was extracted 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 4867 grams of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 365 grams of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 3 times was extracted 2 hours with 8 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.07, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 315 grams of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 396 grams of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 2 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.06, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 375 grams of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 1 hour with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.Be active component 329 grams of the present invention.
Embodiment 8: the preparation tablet
The active component 100g that embodiment 1 obtains adds microcrystalline Cellulose 10g, lactose 10g, and cross-linked pvp 5g, tabletting gets tablet, and every is 0.25g.
Embodiment 9: the preparation granule
The active component 500g that embodiment 2 obtains adds dextrin 100g, xylitol 400g, and citric acid 1g, aspartame 1g granulates, and gets granule, and every bag is 5g.
Embodiment 10: zoopery one: the impact of extract of the present invention on the mouse small intestine progradation
One. materials and methods
Piao's precipitation strongly fragrant ball (lot number: 090867), reach core hall pharmaceutical factory by new Pharmaceutical limited company in Tianjin and produce
Animal: the ICR mice is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK (capital) 2002-0003.
Cisapride is produced by Xian-Janssen Pharmaceutical Ltd., and carbon powder is produced by northization glass purchase and sale center, Tianjin
Arabic gum is produced by Tianjin pharmaceuticals
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random, and namely blank is organized, cisapride positive controls, basic, normal, high group of the strongly fragrant ball group of plain precipitation, the strongly fragrant extract of plain precipitation.dosage is: blank group is filled with purified water, cisapride positive drug group is filled with 10mg/kg cisapride medicinal liquid, the strongly fragrant ball group of Piao's precipitation is filled with 8g crude drug/strongly fragrant ball medicinal liquid of kg Piao's precipitation, the strongly fragrant extract of Piao's precipitation (embodiment 3 method preparations) is low, in, high group is filled with respectively with 2, 4, 8g crude drug/strongly fragrant extract medicinal liquid of kg Piao's precipitation, the administration volume is 20ml/kg, gastric infusion is 7 days continuously, before the last administration, fasting is 16 hours, after administration, 60 minutes every mouse stomaches only give 5% carbon powder (10% arabic gum) suspension 0.3ml/, take off cervical vertebra after 15 minutes and put to death animal, cut open the belly immediately, separate mesentery, the clip upper end is to pylorus, the lower end is to ileocecal intestinal pipe, be tiled on glass plate, draw gently linearly, measuring Length of intestine is " small intestinal total length ", distance conduct " carbon powder is at the enteral advance distance " from pylorus to the carbon powder forward position, calculate ink propulsive rate.
Experimental data is added up with variance analysis.
Two. result: see Table 1.
The impact that the administration of table 1 extract advanced mouse small intestine in seven days
Compare * P＜0.05 with the blank group, △ P＜0.05 is compared with the strongly fragrant ball of plain precipitation in * * P＜0.01
Result shows: the strongly fragrant extract of plain precipitation promotes the function that the strongly fragrant extract of length specification Piao's precipitation that the small intestinal carbon powder advances has good promotion mouse small intestine to advance 4, under the dosage of 8g crude drug/kg 4, under the dosage of 8g crude drug/kg.And the Constipation of the strongly fragrant extract of plain precipitation is better than the strongly fragrant ball of plain precipitation with dosage.
Embodiment 11: zoopery two: the impact that extract of the present invention is emptying on Mouse Stomach
One. method:
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random, and namely blank is organized, cisapride positive controls, basic, normal, high group of the strongly fragrant ball group of plain precipitation, the strongly fragrant extract of plain precipitation.Dosage is: blank group is filled with purified water; Cisapride positive drug group is filled with 10mg/kg cisapride medicinal liquid; The strongly fragrant ball group of Piao's precipitation is filled with 8g crude drug/strongly fragrant ball medicinal liquid of kg Piao's precipitation; Basic, normal, high group of Piao's precipitation strongly fragrant extract (embodiment 3 methods preparations) is filled with respectively with 2,4,8g crude drug/strongly fragrant extract medicinal liquid of kg Piao's precipitation, the administration volume is 20ml/kg, gastric infusion is 7 days continuously, before the last administration, fasting is 16 hours, after administration, 60 minutes every mouse stomaches give the semi-solid paste of trophism (by milk powder, sugar, starch forms) 0.8ml/ only, take off cervical vertebra after 20 minutes and put to death mice.Open abdomen and get stomach, claim stomach full weight and net weight, calculate the gastric residue and account for institute to fill with the percentage by weight of semisolid paste be the gastric residual rate.
Two. result: see Table 2.
The impact emptying on Mouse Stomach in seven days of table 2 extract successive administration
Compare * P＜0.05, * * P＜0.01 with the blank group
Result shows: result shows: the strongly fragrant extract of plain precipitation reduces residual quantity in Mouse Stomach 4, under the dosage of 8g crude drug/kg, illustrates that the strongly fragrant extract of plain precipitation has the good emptying function of promotion Mouse Stomach 4, under the dosage of 8g crude drug/kg.
Claims (5)
1. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of soothing liver-QIization, it is characterized in that: its active component is made by the raw material of following parts by weight: 150 parts of Rhizoma Cyperi (processed with vinegar), 35 parts of Rhizoma Corydalis (processed with vinegar), 50 parts of stir-baked Fructus Aurantii in bran, 35 parts, Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts of Pericarpium Citri Reticulatae Viride (processed with vinegar), 100 parts of Pericarpium Citri Reticulataes, 35 parts, Radix Glycyrrhizae, 35 parts, Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (processed with vinegar), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis; Described active component adopts following method to prepare: take each raw material by proportioning raw materials, and standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.
2. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 1, it is characterized in that: described Chinese medicine composition also contains the acceptable adjuvant of pharmaceutics.
3. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 2, it is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
4. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 2, it is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
5. the preparation method of the Chinese medicine composition of strongly fragrant, the appetite-stimulating indigestion-relieving of a soothing liver-QIization, is characterized in that comprising the steps: to take 150 parts of Rhizoma Cyperi (processed with vinegar), 35 parts of Rhizoma Corydalis (processed with vinegar), 50 parts of stir-baked Fructus Aurantii in bran, 35 parts, Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts of Pericarpium Citri Reticulatae Viride (processed with vinegar), 100 parts of Pericarpium Citri Reticulataes, 35 parts, Radix Glycyrrhizae, 35 parts, Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (processed with vinegar), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis; Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain fine powder A; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and fine powder A mix homogeneously, obtain dry thing II.
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| CN1119537A (en) * | 1994-09-27 | 1996-04-03 | 刘德芳 | Dangyouanwan Chinese proprietary medicine for curing splenopathy gastropathy and meridian pain and its preparing method |
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Non-Patent Citations (2)
| Title |
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| 中华人民共和国卫生部药典委员会.朴沉化郁丸.《中华人民共和国卫生部药品标准 中药成方制剂第十册》.1995,52. |
| 中华人民共和国卫生部药典委员会.朴沉化郁丸.《中华人民共和国卫生部药品标准 中药成方制剂第十册》.1995,52. * |
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