CN102145059B - Chinese patent medicament for treating intractable hypertension - Google Patents

Chinese patent medicament for treating intractable hypertension Download PDF

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CN102145059B
CN102145059B CN2011100865737A CN201110086573A CN102145059B CN 102145059 B CN102145059 B CN 102145059B CN 2011100865737 A CN2011100865737 A CN 2011100865737A CN 201110086573 A CN201110086573 A CN 201110086573A CN 102145059 B CN102145059 B CN 102145059B
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radix
root
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CN102145059A (en
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于国录
薛凤荣
薛影
史克龙
盛渝惠
于海珍
于雪杰
于方
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Abstract

The invention relates to a Chinese patent medicament for treating intractable hypertension, which comprises the following Chinese herbal medicaments in part by weight: 50 to 100 parts of seabuckthorn, 80 to 100 parts of wild thyme, 100 to 150 parts of madagascar periwinkle herb, 100 to 150 parts of ganoderma lucidum karst, 150 to 300 parts of black fungus, 80 to 100 parts of emblic root, 50 to 100 parts of salidroside, 50 to 100 parts of devilpepper root, 200 to 300 parts of kudzuvine root, 200 to 300 parts of hawthorn root and 200 to 300 parts of cassia seed. The medicaments are subjected to reasonable compatibility and are complementary in medicinal effects, so the Chinese patent medicament has good effect of reducing blood pressure, can address both symptoms and root causes, is suitable for patients who suffer from senile hypertension, juvenile hypertension, gestational hypertension, salt-sensitive hypertension and the like and particularly has the special and obvious curative effect on patients who suffer from refractory hypertension; and the Chinese patent medicament has the cure rate of 82.7 percent on the refractory hypertension, and has the total cure rate of 68.6 percent, total effectual rate (cure and effect producing) of 89.3 percent and the total effective rate of 100 percent on various kinds of hypertension, and the hypertension does not relapse after being cured.

Description

The Chinese patent medicine of treatment refractory hypertension
Technical field
The present invention relates to a kind of Chinese patent medicine, particularly relate to a kind of Chinese patent medicine of treating refractory hypertension.
Background technology
Hypertension is a kind of systemic disease by gene genetic, environment and other multiple factor interactions; Be a kind of commonly encountered diseases, frequently-occurring disease; Be to cause one of human cardiovascular and cerebrovascular disease main causes of death at present; Hypertensive sickness rate reaches 10-20% in the world wide, is one of healthy principal disease of harm humans.
China is essential hypertension country occurred frequently, and Chinese residents nutrition in 2004 and Health Situation survey result show, China more than 18 years old resident's hypertension prevalence be 18.8%, estimate that national number of patients surpasses 1.6 hundred million.For this reason, ministry of Health of China proposes annual October 8 as national hypertension day, requires the resident more than 35 years old to detect blood pressure every year at least one time, calls the hypertensive harm of the clear understanding of national people and all medical personnels, actively prevents and treats hypertension.
Hypertensive sorting technique has multiple, is divided into essential hypertension and secondary hypertension by the cause of disease; What also have is divided into gestational hypertension, salt-sensitive hypertension, is owing to insobriety, lack the hypertension that motion, smoking and hyperlipidemia etc. cause in addition; Age-based section is divided into juvenile hypertension and middle and old age hypertension.
Most of hyperpietics adhere to medication in early days, and symptom can be controlled to some extent, can be controlled in below 140/90 millimetres of mercury.But blood pressure can not be effectively controlled yet to still have a considerable amount of patients to take medicine afterwards, relatively refractory.If the hyperpietic improves bad life style (like smoking cessation, limit salt, loss of weight and increase campaign etc.); And take antihypertensive drugs more than three kinds; Through more than 3 months still can not with controlling of blood pressure when the reasonable levels (as hypertension drop to below the 140/90mm mercury column; Diabetes Microalbuminuria patient drops to below the 130/90mm mercury column, albumen every day in the urine>should be below 125/75mm during 1g), intractable (or intractable) hypertension generally be called.In recent years, refractory hypertension patient was high, had increased the danger of heart and brain renal vascular diseases greatly, was necessary to develop the control that more efficient drug is carried out this type disease.
The prevalence of refractory hypertension is higher among the middle-aged and elderly people patient, accounts for 50%, and wherein majority is an ISH; Main cause is that old people's blood vessel elasticity reduces; Vascellum tunica interna incrassation, often with atherosclerosis, this is the main cause of old people's systolic hypertension.Old people's kidney row sodium ability reduces, and hypertension makes the patient be in higher relatively precarious position.Discover that 65-74 year, the hyperpietic of age bracket exceeded 8-10 doubly than the danger with the normotensive old man's cerebrovascular of age bracket.
Gestational hypertension (claiming pregnancy induced hypertension syndrome again) is the peculiar and common disease of pregnancy women, and mother and sons' death is clinical characters when depleted, serious with hypertension, edema, albuminuria, tic, stupor, cardiorenal function.Pregnancy induced hypertension syndrome by the order of severity be divided into slightly, moderate and severe, the severe pregnancy induced hypertension syndrome is claimed preeclampsia and eclamposia again, eclamposia promptly on the hypertension basis often with the tic symptom.
Salt-sensitive hypertension, eating salt too much is to cause one of hypertensive key factor, especially some people, responsive especially to Sal, high salt diet can make blood pressure obviously increase; And after the absorption of strict restriction Sal, blood pressure can descend thereupon, and this hypertension is called salt-sensitive hypertension.Investigation finds in normal population, to have 15%~42% adult to belong to this type of hypertension, and its sickness rate has notable difference because of area, race and age different, and China sees that more than south old people Geng Yi suffers from this type of disease in the north more.
Child and young hypertension symptom majority are not true to type, and also incomplete same with the adult, what have is asymptomatic, the performance headache that has, dizzy, nausea and vomiting, and emotional anger, torpescence, vision has obstacle, even paresis occurs, and the performance dysphoria is prone to exert.This type of patient has the hypertension family history more, and general complication is less, generally apoplexy can not take place, myocardial infarction and renal insufficiency.Except that Drug therapy, also need cooperate necessary non-drug therapy, like many participation physical exertion, keep normal type, restriction edible salt intake and smoking cessation etc.
Through retrieval; Chinese patent CN200710015375.5 discloses a kind of Chinese medicinal capsule of the person in middle and old age's of treatment essential hypertension, the Chinese medicinal capsule that is mixed with by the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Mori, Fructus Ligustri Lucidi, Semen Astragali Complanati, Fructus Tribuli, Herba Cynomorii, Radix Achyranthis Bidentatae, Semen Cuscutae, Semen Raphani, Rhizoma Atractylodis Macrocephalae (parched), Fructus Lycii, Semen Plantaginis, Semen Cassiae, Flos Chrysanthemi, Radix Polygalae, Rhizoma Acori Graminei, Herba Asari.Chinese patent CN00112443.9 discloses a kind of Chinese medicine of treating hypertension, is made up of Herba Siegesbeckiae, Radix Gentianae, Spica Prunellae, Radix Scutellariae, Rhizoma Coptidis, Fructus Lycii, Radix Bupleuri, Rhizoma Alismatis, Folium Ginkgo, Herba Apocyni veneti etc.The hypertensive Chinese medicine of above-mentioned treatment is too much paid attention to regulating, and effect is slow, and the course of treatment is long, and effect is undesirable.
Summary of the invention
The technical problem that the present invention will solve: be to overcome the defective that prior art exists, provide a kind of and can effectively treat various hypertensions, particularly can treat the Chinese patent medicine of intractable hypertension.
Technical scheme of the present invention:
A kind of Chinese patent medicine of treating refractory hypertension is made up of following bulk drugs, Fructus Hippophae 50-100 part, Herba thymi vulgaris 80-100 part; Herba Catharanthi Rosei 100-150 part, Ganoderma 100-150 part, Auricularia 150-300 part; Emblic daughter root 80-100 part, Radix Rhodiolae 50-100 part, Radix Rauvolfiae 50-100 part; Radix Puerariae 200-300 part, Fructus Crataegi 200-300 part, Semen Cassiae 200-300 part.
Said crude drug is Fructus Hippophae 70-80 part, Herba thymi vulgaris 85-95 part, Herba Catharanthi Rosei 110-130 part, Ganoderma 120-140 part; Auricularia 200-260 part, emblic daughter root 90-100 part, Radix Rhodiolae 60-80 part, Radix Rauvolfiae 60-90 part; Radix Puerariae 220-260 part, Fructus Crataegi 220-280 part, Semen Cassiae 220-280 part.
Said crude drug is Fructus Hippophae 50-70 part, Herba thymi vulgaris 90-100 part, Herba Catharanthi Rosei 120-150 part, Ganoderma 100-130 part; Auricularia 150-240 part, emblic daughter root 80-90 part, Radix Rhodiolae 50-80 part, Radix Rauvolfiae 50-80 part; Radix Puerariae 240-300 part, Fructus Crataegi 260-300 part, Semen Cassiae 200-260 part.
Said crude drug is Fructus Hippophae 70-100 part, Herba thymi vulgaris 90-100 part, Herba Catharanthi Rosei 100-130 part, Ganoderma 130-150 part; Auricularia 240-300 part, emblic daughter root 80-90 part, Radix Rhodiolae 80-100 part, Radix Rauvolfiae 80-100 part; Radix Puerariae 200-260 part, Fructus Crataegi 200-260 part, Semen Cassiae 260-300 part.
Said Fructus Crataegi is a Crataegi cuneatae, and the dosage form of said Chinese patent medicine is soft capsule, pill, powder or tablet.
Chinese patent medicine instructions of taking of the present invention:
The soft capsule instructions of taking: once-a-day, each two to three, every contains former medicine 0.5 gram, uses warm water delivery service behind the 30min after meal, and 60 days is a course of treatment.Decide dose according to state of an illness weight, course of disease length are different with body constitution, the wine of banning on opium-smoking and the opium trade during the treatment, few Sal are strengthened physical exercise.Other dosage forms such as pill, powder or tablet can be with reference to this dose.
Chinese patent medicine pharmacology analysis of the present invention:
The present invention is the basis with motherland's Chinese medicine and pharmacy theory, in conjunction with the clinical practice in surplus the inventor 30 year, from motherland's medical treasure-house, filters out and has the crude drug that bar reaches wood gas, mediation retardance, can repair impaired target organ; This prescription can make patient's QI and blood full; Fundamentally replenish living matter,, make blood limpid impaired organ restore funcitons gradually; Blood vessel elasticity increases, nourishing liver spleen kidney; Sun rising clearly, turbid yin are descended, and vigor strengthens, and patient's blood pressure is not steadily rebounded, and avoids producing cardiovascular and cerebrovascular disease, alleviates the patient suffering, particularly can effectively solve intractable property hyperpietic's misery, and can thoroughly cure.It is monarch drug that the present invention selects Fructus Hippophae, Herba thymi vulgaris, Herba Catharanthi Rosei for use, and Ganoderma, Auricularia, emblic daughter root are ministerial drug, reasonable compatibility; Contain multiple type of blood pressure lowering peptide in raw material Fructus Hippophae, Ganoderma, the emblic daughter root, multi-pronged, drug effect is complementary, and antihypertensive effect is good.
Fructus Hippophae in the side: lightly seasoned, warm in nature; Relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, promoting blood circulation to remove blood stasis can enhancing immunity, has the effect of prophylaxis of tumours, defying age, blood fat reducing and blood pressure lowering.Herba thymi vulgaris, another name Herba Thymi, Herba thymi vulgaris, nature and flavor are hot, tepor; Have expelling pathogenic wind from the body surface, promoting the circulation of QI to relieve pain, cough-relieving and buck functionality.Herba Catharanthi Rosei, another name Herba amaranthi tricoloris, everyday new, nature and flavor are cool, and are poisonous, mildly bitter flavor; Suppressing the hyperactive liver and subsiding YANG, removing heat from blood blood pressure lowering, tranquillizing and allaying excitement, heat clearing and inflammation relieving and anti-cancer function are arranged; Be used for diseases such as hypertension, burning hot wound, malignant lymphoma and monocytic leukemia.
Ganoderma has another name called Ganoderma lucidum (Leyss. Ex Fr.) Karst., Ganoderma lucisum, is the red kind of Ganoderma, and nature and flavor are bitter, flat, nontoxic; The Compendium of Materia Medica record, Ganoderma lucidum (Leyss. Ex Fr.) Karst. is cured hundred diseases, and the well-informed magical effect belongs to medicinal and edible plant, and blood circulation is had blood pressure lowering and strengthens the heart contraction effect, is used for diseases such as hypertension, coronary heart disease, hyperlipidemia.Auricularia, another name Auricularia, light Auricularia, nature and flavor are sweet, and are flat; Fill blood, lung moistening, hemostasis; Invigorating the spleen and benefiting QI is arranged, eliminate the phlegm, be used for diseases such as hypertension, sclerosis of blood vessels, retinal hemorrhage wet and dysentery relieving hemostatic function.The emblic daughter root, the another name Radix Phyllanthi is the root or the root bark of euphorbia plant phyllanthus emblica, sweet in the mouth, acid are cold in nature, nontoxic, have effects for removing toxic heat, can be used for diseases such as hypertension, diarrhoea.
Radix Rhodiolae, property is flat, and sweet-puckery flavor has benefiting QI for activating blood circulation, a function of relievining asthma of promoting blood circulation, and is used for diseases such as hypertension, diabetes, insomnia forgetfulness.Radix Rauvolfiae, another name fish gallbladder wood, mountain Horse hoof, nature and flavor are bitter, cold; Calmness, blood pressure lowering arranged, invigorate blood circulation, pain relieving, heat clearing away and Detoxication, be used for diseases such as hypertension, headache, dizzy, insomnia and cholecystitis.Crataegi cuneatae has another name called Fructus Crataegi cuneatae, crataegus cuneata, red fruit, contains abundant vitamin, Crataegolic acid, citric acid, flavonoid etc.; Sweet in the mouth, acid, warm in nature, promoting digestion and removing stagnation, pain relieving dissipating blood stasis are arranged, blood fat reducing with alleviate arteriosclerotic effect, but angiocardiopathy preventing is used to have a weak heart, disease such as coronary atherosclerosis.Semen Cassiae, bitter in the mouth, sweet, salty, cold nature is gone into liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing makes eye bright, and is used to treat diseases such as constipation, hyperlipidemia and hypertension, and the effect of blood pressure lowering, blood fat reducing is arranged.
Concrete case and statistical effect:
The applicant from the eighties so far, the hyperpietic in all parts of the country of treatment is countless, 2815 examples is arranged, male's 1534 examples wherein, women's 1281 examples, 1892 examples more than 55 years old through statistics.What patient's course of disease was the shortest is 2 months, and the longest reaches 48 years.
Model case:
Case 1: the Wang, the man, 58 years old, near the people clear water gulf, Xiangcheng City, Henan Province examined November 3 1989 time.Patient's readme: existing 16 years of hypertension, closely half a year, vertigo and tinnitus increased the weight of, and women's head-ornaments are warmed, nervous increasing the weight of, thirst but no desire to drink, spiritlessness and weakness, extremity are stranded heavy, and lower limb are sent out cold, blood pressure 178/98mmHg.Hope its flushing as woman's persona, body of the tongue is light red, white and thin fur, deep,thready and forceless pulse.With taking medicine by the prescription of embodiment 3, method of administration, once-a-day, each three, every contains former medicine 0.5 gram, use warm water delivery service after 30 minutes after meal, treats 40 days, does not follow up a case by regular visits to so far and recurs.
Case 2: Ma, the woman, 51 years old, Guan Hui town Li Si cheated, and came me institute to go to a doctor on July 22nd, 1998, suffered from renal hypertension 7 years; Blood pressure 182/110-120mmHg got fat in nearly 2 years unusually, and the vomiting tripe expands, anorexia and loose stool, dizzy fear of cold; Biped is ice-cold, and is as speeding across the sky, fat and unable when dizzy, and waist is stranded as folding, dribbling urination; Cough the then enuresis, foot is stepped on Cotton Gossypii sense, and women's head-ornaments are conscious to have a Hong hotness, noon flushed complexion such as liquor-saturated, the time aphtha arranged; Pale tongue is fat, and there is indentation on the limit, and tongue is greasy in vain, and the arteries and veins flood is not appointed and pressed, and feels fine as silk by anti-for a long time.Prescription by the embodiment of the invention 5 was treated five months, and all diseases are all healed, and blood pressure is normal.
Case 3: Zhang, the man, 64 years old, the retired cadre of Henan Province Gourmet Powder Factory, on August 19th, 2000 went to a doctor; Existing 24 years of hypertension, nearly half a year, dizziness and tinnitus increased the weight of, and women's head-ornaments are warmed, and are moving then nervously pant poor appetite; Thirst but no desire to drink, spiritlessness and weakness, drowsy, extremity are aching and tired, and lower limb are sent out cold; Blood pressure 195/120mmHg hopes its light red tongue, white and thin fur, deep,thready and forceless pulse.By the prescription of the embodiment of the invention 10 treatment five days, all diseases alleviated, after to take January continuously surplus, nearly 3 years of blood pressure is normal always.
Case 4: stone, woman, 41 years old, Wang Ming mouth township, Xiangcheng City Yuan Zhai people from village; Go to a doctor June 23 nineteen ninety-five, shows as fidgety 4 years of dizzy insomnia, xerostomia, and blood pressure is through being everlasting between the 155-180/110-100mmHg, and tongue is red and dried; Yellow and thin fur, rolling pulse is examined upon somebody's introduction, treats 20 days by the prescription of embodiment 15; All diseases alleviate, after took continuously 40 days, cure.Normal always through following up a case by regular visits to existing 6 years blood pressures, it is very magical that the patient feels.
Case 5: Jiang, the woman, 68 years old, Xiangcheng City east people from street, on JIUYUE 16th, 1988 went to a doctor, and the patient has surplus the hypertension ten year, and the normal phase is taken medicines such as FUFANG JIANGYA PIAN, nifedipine, and blood pressure does not have obvious decline.Patient's lethargy is depressed in recent years, the vertigo, and desire is fallen forward, fatigue and weakness, coldness of the body with chills; Need wear underwear during summer, thirsty desire for hot drinks, tastelessness, anorexia, cardiopalmus; oliguria, nocturia, corpulent tongue is big, Tai Bai and approaching; deep and thready pulse, through taking medicine of the present invention, the bimester of pressing the prescription treatment of embodiment 15, does not send out through following up a case by regular visits to so far.
Case 6: shut out certain, woman, 54 years old, Huaiyang County bean door village people, the prescription on individual diagnosis on the 27th of nineteen ninety December.Patient main suit: vexed, depressed, it is more than, uncomfortable in chest to sigh, sleeplessness whole night, and the angel poor appetite, numb hand and foot trembles, permanent current nose bleeding, blood pressure 165-170/100-105mmHg.Father and mother elder sister and younger brother is the hyperpietic, does not all cure, and oneself has thoughts of suicide; Father dies from cerebral hemorrhage, and mother's hemiplegia is at bed, and elder sister also is a cerebral infarction; Still undesirable through the multi-treatment blood pressure, after the acquaintance introduces the court, treat ten days all diseases by the prescription of embodiment 15 and alleviate; Go to a doctor for the second time and be with younger brother to treat simultaneously, two cured per capita in 2-3 month.She elder sister and younger brothers recommended a lot of hypertensive patients to cure the disease to the inventor afterwards.
Case 7, Liu, the man, 32 years old, the Shenqiu County connected Chi Jiren; On August 11st, 2005 examined, and the patient had the nephropathy history 7 years, once used western medicines in treatment, and is bad during state of an illness fashion, can not thoroughly stablize or alleviate; Owing to take hormone for a long time, blood pressure rises to 200-210/115-120mmHg in the recent period, and it is obstructed to have a stuffy nose, anosmia; Aversion to cold and cold limbs is ached all over, and the work of not enduring hardships has lost treatment confidence.Disease is seen: corpulent tongue is big, and there is indentation on the limit, white and thin fur, and floating pulse is unable; Chi portion more very introduces the court to go to a doctor through the friend, presses the prescription treatment first quarter moon of embodiment 4, and spirit is changed; Treatment confidence has been arranged, taken medicine of the present invention again two months, blood pressure was all more satisfactory in recent years through following up a case by regular visits to.
Case 8, Dong, woman, 44 years old; Xiangcheng City is engaged in the catering trade in the industry road, and on February 9th, 2007 went to a doctor, and the patient has chronic diabetes nephropathy, hypertension, takes glyburide, diamicron, nifedipine sheet slow releasing tablet in recent years always; Controlling of blood pressure is still undesirable, and trial edition invention medicine is had a surplus January, and all diseases alleviate, and mood is very delight; Took medicine of the present invention again four months, blood pressure and blood sugar all compares normally, cures.
Case 9, the Wang, the man, 69 years old, people from Zhoukou City, on February 6th, 2000, I went him house to see him, was a friend's of inventor father.Trouble hypertension is more than ten years, and the people is thin partially, and complexion is a bit dark, and tongue is purple partially dark; The obvious varicose of sublingual vessel is pointed ten meniscuss and is not had entirely, and tongue fur is not a lot, but a yellowish and greasy fur is arranged; From the picture of the tongue complexion, be typical Blood stasis, pulse condition is heavy thin strong, the inventor with medicine of the present invention let him take; Second day old man feels that whole body is strong, and be clearheaded, obeys healing in two months again.10 years subsequently, I went to see him every year, and blood pressure does not exceed always, and the old man has just seen and overstates, is the life that the inventor has rescued him.
Case 10: Ma, woman, 69 years old, the retired professor in Xiangcheng City; On March 17th, 1993 went to a doctor, and this Ms is that the typical case eats next hypertension, and is more fat, the face circle; Big face is blushed scarlet, wood gas stasis that Here it is, say from doctor trained in Western medicine; Be facial telangiectasis institute extremely, so the general bright red of face reaches an advanced stage and possibly just become aubergine.Just begun stasis heavier the time, glowing with health, give the sensation of a kind of very strong firm of people on the contrary, this is that empty sun is more floating; Extremely disease sees that body of the tongue is purplish red to not enough of convergence, and tongue fur is satiny; Pulse condition is slided greatly but is not very heavy, takes the prescription of medicine embodiment 22 of the present invention and treats several days, and it is very comfortable that the patient feels; Took a course of treatment afterwards continuously, cured, and followed up a case by regular visits to and all compare normally always.
The clinical statistics data see the following form 1:
Figure 317105DEST_PATH_IMAGE001
Table 1 explanation: belong to obstinate hypertension among the patient, belong to senile hypertensive again, by the obstinate hypertension statistics; Belong to salt-sensitive hypertension, belong to senile hypertensive again, by salt-sensitive hypertension patient statistics.
Positive beneficial effect of the present invention:
(1) medicine of the present invention just sums up out through for many years exploration, test according to Traditional Chinese medical theory.Facts have proved that this medicine composition compatibility is reasonable, drug effect is complementary; Antihypertensive effect is better, and the ability treating both the principal and secondary aspects of a disease is applicable to patients such as senile hypertension, juvenile hypertension, gestational hypertension and salt-sensitive hypertension; Particularly obstinate hypertension is had special efficacy, curative effect is obvious.Can know that from table 1 it is 82.7% that this medicine reaches the cure rate of intractable hypertension; All kinds of hypertensive total cure rates are reached 68.6%, and total obvious effective rate (curing and produce effects) reaches 89.3%, and total effective rate reaches 100%, and does not rebound after curing.
(2) Chinese patent medicine compatibility of the present invention is good, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, regulating yin and yang; Demonstrate the treatment advantage of Chinese medicine, not only can not damage Liver and kidney, can also effectively protect the heart, brain, kidney; And Chinese medicine is inexpensive, toxic and side effects is little, and is less to the target organ influence, can treat the incurable intractable hypertension of general Western medicine; General patient treatment was cured in 1~2 month, and intractable hypertension can be cured for 3~June.Therapeutic Method is simple, need not during the patient treatment to be in hospital, and has instant effect, less patient suffering is little, cost is low, advantage such as safe, is easyly accepted by the patient.
(3) Chinese patent medicine raw material of the present invention is easy to get, and cost is low, and processing is simple, easy to implement with apply.
The specific embodiment
Embodiment 1-12: a kind of Chinese patent medicine of treating refractory hypertension, concrete crude drug composition is seen table 2.
Method for making: after crude drug mixed, add the water of crude drug 10-15 times weight, decocts 2-3 time, filter, be concentrated into and contain the medicinal liquid of moisture below 5%, the employing conventional method is prepared soft capsule, and every contains crude drug 0.5 and restrains.
Embodiment 13 ~ 24: a kind of Chinese patent medicine of treating refractory hypertension, the crude drug composition is seen table 3.
Method for making: crude drug is pulverized, sieved, mixing, process pill, powder or tablet by conventional method.
The crude drug proportioning of table 2 various embodiments of the present invention, unit is gram.
Figure DEST_PATH_IMAGE002
?[0042]?
The crude drug proportioning of table 3 various embodiments of the present invention, unit is gram.
Figure 296562DEST_PATH_IMAGE003

Claims (5)

1. a Chinese patent medicine of treating refractory hypertension is characterized in that: be made up of Fructus Hippophae 50-100 part, Herba thymi vulgaris 80-100 part following bulk drugs; Herba Catharanthi Rosei 100-150 part, Ganoderma 100-150 part, Auricularia 150-300 part; Emblic daughter root 80-100 part, Radix Rhodiolae 50-100 part, Radix Rauvolfiae 50-100 part; Radix Puerariae 200-300 part, Fructus Crataegi 200-300 part, Semen Cassiae 200-300 part.
2. Chinese patent medicine according to claim 1 is characterized in that: said crude drug is Fructus Hippophae 70-80 part, Herba thymi vulgaris 85-95 part; Herba Catharanthi Rosei 110-130 part, Ganoderma 120-140 part, Auricularia 200-260 part; Emblic daughter root 90-100 part, Radix Rhodiolae 60-80 part, Radix Rauvolfiae 60-90 part; Radix Puerariae 220-260 part, Fructus Crataegi 220-280 part, Semen Cassiae 220-280 part.
3. Chinese patent medicine according to claim 1 is characterized in that: said crude drug is Fructus Hippophae 50-70 part, Herba thymi vulgaris 90-100 part; Herba Catharanthi Rosei 120-150 part, Ganoderma 100-130 part, Auricularia 150-240 part; Emblic daughter root 80-90 part, Radix Rhodiolae 50-80 part, Radix Rauvolfiae 50-80 part; Radix Puerariae 240-300 part, Fructus Crataegi 260-300 part, Semen Cassiae 200-260 part.
4. Chinese patent medicine according to claim 1 is characterized in that: said crude drug is Fructus Hippophae 70-100 part, Herba thymi vulgaris 90-100 part; Herba Catharanthi Rosei 100-130 part, Ganoderma 130-150 part, Auricularia 240-300 part; Emblic daughter root 80-90 part, Radix Rhodiolae 80-100 part, Radix Rauvolfiae 80-100 part; Radix Puerariae 200-260 part, Fructus Crataegi 200-260 part, Semen Cassiae 260-300 part.
5. according to each described Chinese patent medicine of claim 1-4, it is characterized in that: said Fructus Crataegi is a Crataegi cuneatae.
?
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曹云.中医药治疗高血压病临床研究进展.《光明中医》.2010,第25卷(第2期),322-323. *

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