CN100551426C

CN100551426C - A kind of induce sweat, dry and in dispersible tablets of Chinese medicine and preparation method thereof

Info

Publication number: CN100551426C
Application number: CNB2006100026793A
Authority: CN
Inventors: 李祖泽; 施少斌; 郑荣波; 沈军; 黄晓丹
Original assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Current assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority date: 2006-01-27
Filing date: 2006-01-27
Publication date: 2009-10-21
Anticipated expiration: 2026-01-27
Also published as: CN101007148A

Abstract

The invention provides a kind of have induce sweat, dry and in Chinese medicine composition and preparation method thereof.This medicine is to make dispersible tablet by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, dried tangerine peel, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis, and it is rapid that medicine of the present invention has an onset, the characteristics that dissolution rate is high.Pharmacodynamics test shows that the effect of employing medicine of the present invention and commercially available Health pill are similar, but its pharmacodynamic action is better than commercially available Health pill.

Description

A kind of induce sweat, dry and in dispersible tablets of Chinese medicine and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly, relate to Chinese medicine be a kind of that raw material is made induce sweat, dry and in dispersible tablets of Chinese medicine and preparation method thereof.

Background technology

Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, these symptoms can be caused by multiple reason.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is a kind of traditional Chinese medicine, is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials; general ball; coating ", its productive labor intensity is big, with low content of technology, prescription Chinese medicine effective ingredient is not extracted, thereby cause Health pill to exist the medicine active ingredient in gastrointestinal dissolution rate and absorbance reduction, soak time prolongs, and onset is slow, and because Health pill bad smell when taking can make the patient produce resentment.

Chinese invention patent number 200410027334.4 titles are made and are protected the Ji sheet, decoct with water owing to Ramulus Uncariae Cum Uncis in its technology that adopts, be not easy to extract fat-soluble effective ingredient in the Ramulus Uncariae Cum Uncis, and multiple medical material as: Six-element medicines such as the Radix Aucklandiae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Pogostemonis adopt CO respectively ₂The process more complicated of extraction, the cycle of finishing production is long, and cost is higher.

Summary of the invention

The purpose of this invention is to provide a kind of have induce sweat, dry and in dispersible tablets of Chinese medicine.

Another object of the present invention provide a kind of have induce sweat, dry and in the preparation method of dispersible tablets of Chinese medicine.

Medicine of the present invention is to be made by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, dried tangerine peel, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.By test, the dispersant adjuvant of select determining in many adjuvants is made a kind of have induce sweat, dry and in dispersible tablets of Chinese medicine.

Preparing medicine material weight portion proportioning of the present invention is: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, tangerine 36.70～125.40 parts, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemoniss, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.

Preferred medicine material weight portion proportioning of the present invention is: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, tangerine 54.48～81.73 parts, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemoniss, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss.

Best medicine material weight portion proportioning of the present invention is: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of dried tangerine peels, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemoniss, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss.

The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.Medicine of the present invention can adopt the conventional preparation method preparation of at present common dispersant.The present invention can adopt wet granulation, mixes before tabletting, and tabletting is made dispersible tablet; The present invention can adopt non-water to granulate: the extract dry ingredient is granulated with on-aqueous liquid (as ethanol) in will writing out a prescription, and tabletting is made dispersible tablet; The present invention can adopt direct compression process: with suitable component mix homogeneously, direct compression is made dispersible tablet; The present invention can adopt the dry granulation method: with component with hydraulic pressure or double compression corning.

The present invention adopts following technology to extract, and employing is prepared as follows method and prepares dispersible tablet, is intended to further specify the present invention, but the present invention is not construed as limiting.

The present invention induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, tangerine 36.70～125.40 parts, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemoniss, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 1～10 times of amount; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 1～4 time of 2～10 times of amounts, and each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2～10 times of amounts, 30～99% ethanol extractions 1～4 time, and each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder, dextrin embedding thing and dispersant adjuvant mixing granulation, tabletting.

Preferred the present invention induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, tangerine 54.48～81.73 parts, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemoniss, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3～8 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 1～3 time of 3～8 times of amounts, and each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, and each 0.5～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

Further preferred the present invention induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

A. get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, tangerine 68.20 parts, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemoniss, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3.5～6 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, and each 1～2 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3.5～6 times of amounts, 55～90% ethanol extractions 2 times, and each 1～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

Best the present invention induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

Above-mentioned induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that dispersant adjuvant among the step c contains one or more in disintegrating agent, filler, lubricant, the binding agent.

Preferred above-mentioned induce sweat, dry and in dispersible tablets of Chinese medicine, wherein said disintegrating agent comprises and is selected from crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, carboxymethylcellulose calcium, the tween 80 one or more; Described filler comprises and is selected from lactose, microcrystalline Cellulose, pregelatinized Starch, mannitol, starch, erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, trehalose, D-ribose, low melting-point agarose, Lac, arabic gum, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, dextrin, the maltose one or more; Described lubricant comprises and is selected from magnesium stearate, Pulvis Talci, Polyethylene Glycol, the micropowder silica gel one or more; Described adhesive comprises and is selected from water, ethanol, polyvinylpyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, the natural clay silica gel magnalium one or more.

Further preferred above-mentioned induce sweat, dry and in dispersible tablets of Chinese medicine, wherein said disintegrating agent comprises and is selected from crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, the cross-linking sodium carboxymethyl cellulose one or more; Described filler comprises and is selected from lactose, microcrystalline Cellulose, pregelatinized Starch, sorbitol, arabic gum, the xylitol one or more; Described lubricant comprises and is selected from magnesium stearate, the micropowder silica gel one or more; Described adhesive comprises and is selected from water, ethanol, polyvinylpyrrolidone, the hydroxypropyl cellulose one or more.

Best above-mentioned induce sweat, dry and in dispersible tablets of Chinese medicine, wherein said disintegrating agent comprises and is selected from a kind of of crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose or both mix; Described filler comprises that being selected from a kind of of lactose, microcrystalline Cellulose or both mixes; Described lubricant is a magnesium stearate; Described adhesive is polyvinylpyrrolidone-alcoholic solution.

Above-mentioned induce sweat, dry and in dispersible tablets of Chinese medicine, the disintegrating agent among the step c wherein: dry extract fine powder and dextrin embedding thing gross weight are 0.2～4: 1; Used filler: dry extract fine powder and dextrin embedding thing gross weight are 0.1～3: 1; Used lubricant: dry extract fine powder and dextrin embedding thing gross weight are 0.05～1: 1; Used adhesive: dry extract fine powder and dextrin embedding thing gross weight are 0.05～1: 1.

In the dispersible tablet of the present invention, described Massa Medicata Fermentata is the Guangdong Massa Medicata Fermentata, and tangerine is that Exocarpium Citri Grandis, Herba Pogostemonis are Herba Pogostemonis.

The present invention induce sweat, dry and in the preparation method of dispersible tablets of Chinese medicine, comprise the steps:

A. it is even to get dry extract fine powder, dextrin embedding thing, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, lactose, microcrystalline cellulose mixt;

B. add polyvinylpyrrolidone-alcoholic solution and make soft material, sieve, granulate; Drying, granulate adds the magnesium stearate mixing, and tabletting promptly gets dispersible tablet.

Can add an amount of correctives such as Oleum menthae, menthol, artificial Rhizoma et radix valerianae, Cortex Cinnamomi and other fruity etc. in the medicine of the present invention.

Can add an amount of sweeting agent in the medicine of the present invention as sugar, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid (sodium), glycyrrhizin, alcohol sugar, radix asparagi sweet extract etc.

More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

Dispersible tablet means the rapid homodisperse a kind of tablet of disintegrate of energy in water, is a kind of quick-effective preparation that development in recent years is got up, because its distinctive advantage more and more is subjected to people's attention.

(1) compares with conventional tablet

Dispersible tablet has the following advantages:

1. good dispersing state, disintegration time are short, the medicine stripping is rapid;

2. absorption is fast, bioavailability is high

3. taking convenience can be swallowed, chew to contain and suck or with taking onset, disease controlling effectively after the aqueous dispersion.

(2) compare with dispersible tablet, freeze-dried instant sheet,

The production technology of dispersible tablet is identical with conventional tablet, does not need gas-producing disintegrant, does not need the gentle relative humidity in control room, does not need vacuum lyophilization and extra package, need not specific (special) requirements, and production cost is low.

(3) compare with drop pill

Dispersible tablet and drop pill are all quick-effective preparation, and dispersible tablet takes that mode is various, and disintegrate is faster, the bioavailability height, and production equipment is identical with conventional tablet, need not to add again equipment.

(4) compare with oral liquid

Dispersible tablet is in external disintegrate, has oral liquid and absorbs fast advantage, has productions simultaneously, carries, convenient transportation and advantage such as stablize.

In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.These test examples comprise the pharmacodynamics test of medicine of the present invention.Below used medicine prepares according to embodiment 15 methods in the test.

Test example 1

Medicine of the present invention is to the mice gastric emptying, the influence of intestinal propulsion

Medicine of the present invention according to the preparation of embodiment 15 methods, grinds, and adds water and becomes pasty state.

Control drug: Health pill, commercially available, adopt identical pastel.

1. adopt the semi-solid gastric emptying experimental technique of mice, observe medicine of the present invention normal mouse and dopamine hydrochloride are caused the influence of mice delayed gastric emptying, the result shows: (1) medicine of the present invention, Health pill are not obvious to the normal mouse gastric emptying.(2) the simple dopamine hydrochloride group of nutrition paste residual quantity significantly reduces (P＜0.01 or P＜0.05) in two dosage of medicine of the present invention (1.85g/kg, 3.70g/kg), Health pill (1.85g/kg), fourth woods (5mg/kg) stomach, and medicine of the present invention, the Health pill of prompting doses all have antagonism to the mice delayed gastric emptying that dopamine hydrochloride causes.

2. adopt mouse small intestine charcoal end propulsion trial, observe medicine of the present invention and contrast medicine Health pill, and at neostigmine, epinephrine, atropine cause that mouse small intestine advances antagonism hyperfunction or that suppress the propulsive influence of small intestine movement of mice.The result shows that (1) medicine low dose of the present invention has the propulsive effect of the small intestine movement of mice of quickening, and two dosage effects of middle and high dosage and Health pill are not obvious.(2) small intestinal that causes at neostigmine of two dosage of middle and high dosage of medicine of the present invention and Health pill is hyperfunction an inhibitory action.(3) medicine high dose of the present invention causes that to atropine intestinal propulsion suppresses antagonism is arranged, and two dosage effects of little, middle dosage and Health pill are not obvious.(4) three dosage of medicine of the present invention cause that at epinephrine intestinal propulsion suppresses antagonism is arranged, and the Health pill effect is not obvious.

Above result shows, medicine doses of the present invention causes that at neostigmine mouse small intestine advances the hyperfunction inhibitory action that has, and the mouse small intestine that epinephrine or atropine are caused advances and suppresses also to have certain antagonism.Results suggest, medicine of the present invention has regulating action to mice gastric emptying, intestinal motility disorder.One of symptom that medicine of the present invention cures mainly is a gastrointestinal upset, dyspepsia, and both all can show the gastrointestinal motility dysfunction, this effect should be that its treatment gastrointestinal is not transported, one of dyspeptic pharmacological action.

The result shows, drug effect of the present invention and Health pill effect acquaintance, and medicine of the present invention also causes that to epinephrine intestinal propulsion suppresses antagonism is arranged, and Health pill except that epinephrine is caused mouse small intestine advance the effect that suppresses not obvious.

Medicine antidiarrheal of the present invention, analgesia and spasmolysis test.

1. the test of mouse anti diarrhoea shows: three dosage of medicine of the present invention and two dosage of Health pill cause the diarrhea of mouse model with Folium Sennae obvious diarrhea effect.Show as 6 hours accumulative total of administration group and rush down following just number of times than the obvious minimizing of matched group (P＜0.05 or P＜0.01), in the medicine wherein of the present invention, low dose of (3.70g/kg, 1.85g/kg), and Health pill low dose (1.85g/kg) after giving the agent of Folium Sennae diarrhea inducing second 2 hours and the 3rd were rushed down down just in 2 hours, and number of times also obviously reduces (P＜0.05 or P＜0.01) than matched group.

2. (1) hot-plate analgesic test shows: after medicine low dose of the present invention (1.85g/kg) administration 120 minutes, 90 minutes, 120 minutes pain thresholds were than the obvious rising of matched group (P＜0.05 or P＜0.01) after middle high dose (3.70g/kg, the 5.55g/) administration; Dosage in the Health pill (3.70g/kg), high dose administration 60 minutes, pain threshold was than the obvious rising of matched group (P＜0.05 or P＜0.01) in 90 minutes.

(2) test of acetic acid twisting method shows, each dosage group of medicine of the present invention and Health pill and matched group are relatively, the equal no significant difference incubation period of writhing response (P＞0.05), medicine high dose group of the present invention (5.55g/kg) is turned round the body number of times and is obviously reduced (P＜0.05) than matched group, two dosage groups of Health pill also have certain minimizing, but difference not significantly (P＞0.05).

The result shows that medicine of the present invention and Health pill have certain analgesic activity, but onset is slow and effect a little less than.

3. the test of isolated rabbit small intestinal and stripped small intestine of guinea pig spasmolysis shows that medicine doses of the present invention causes that to acecoline the spastic contraction of isolated rabbit ileum has certain antagonism.The spastic contraction of guinea pig ileum that histamine phosphate is caused has tangible antagonism, and the tonicity of dosing metagaster obviously descends.

Results suggest, medicine of the present invention has certain spasmolysis, and the Health pill spasmolysis of same dose is not obvious.

Medicine Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion of the present invention and to the influence of rat tolerance secretion

1. adopt the sticking damage model of touching of acidic alcohol rat acute stomach; observe the sticking effect of touching damage of anti-acute stomach of medicine of the present invention and Health pill; the result shows that three dosage of medicine of the present invention (0.925g/kg, 1.85g/kg, 33.70) and Health pill (1.85g/kg) can reduce obviously that the stomach of rat model is sticking touches damage index, and the stomach of point out two kinds of preparations that some foreign substance is caused glues to be touched acute injury protective effect is arranged.

2. adopt rat pylorus ligature law stomachial secretion test to show, in the medicine of the present invention in, low dosage (1.85,0.925g/kg) do not have tangible influence to the pylorus ligation rat tolerance secretion; High dose (3.70g/kg) shows as gastric secretion, total acid output obviously reduces than matched group, points out this dosage that gastric acid secretion is had inhibitory action.Health pill (1.85g/kg) does not have tangible influence to stomachial secretion.

In order to understand the present invention better, with drug dissolution comparative experiments of the present invention advantage of the present invention is described below.

Test example 2 dispersible tablets of the present invention and the comparative experiments of ordinary tablet dissolution

Dispersing uniformity: meet pharmacopeia regulation, promptly in 20 ± 1 ℃ of water, all disintegrates and sieve in three minutes by No. 2.

Test medication: medicine dispersible tablet of the present invention (according to the preparation of embodiment 15 methods); Ordinary tablet is the preparations of 200410027334.4 patent documentation embodiment 4 methods according to application number.

Dissolution test, result of the test sees Table one.

Table one dispersible tablet of the present invention and the comparative experiments of ordinary tablet dissolution

To those skilled in the art, technology contents disclosed according to the present invention, those skilled in the art will very clear other embodiment of the present invention, and the embodiment of the invention is only as example.Under the situation of not violating purport of the present invention and scope, can carry out various changes and improvements to the present invention.For example; use different effective ingredients or active constituents of medicine and dispersant adjuvant provided by the invention to adopt identical or obstructed preparation method to make dispersant; but as long as use dispersant adjuvant of the present invention, all within protection domain of the present invention.

The specific embodiment

Further set forth the preparation method of medicine of the present invention by the following examples.

Embodiment 1:

A. get prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae g0.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrates; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 85g, cyclodextrin inclusion compound 50g, microcrystalline Cellulose 160g, mannitol 120g, carboxymethyl starch sodium 50g, micropowder silica gel 5g, low-substituted hydroxypropyl cellulose 30g, the about 150ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 2:

A. get prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrates; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid, reclaims ethanol, and the extracting solution concentrate drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 93g, cyclodextrin inclusion compound 48g, microcrystalline Cellulose 154g, mannitol 120g, carboxymethyl starch sodium 55g, micropowder silica gel 5g, low-substituted hydroxypropyl cellulose 25g, the about 150ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 3:

A. get prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, tangerine 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil betacyclodextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrates; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 95g, cyclodextrin inclusion compound 45g, microcrystalline Cellulose 155g, mannitol 100g, carboxymethyl starch sodium 35g, micropowder silica gel 15g, xylitol 30g, low-substituted hydroxypropyl cellulose 25g, the about 180ml of 75% ethanol; With above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, xylitol, micropowder silica gel, low-substituted hydroxypropyl cellulose mix in mixing channel, with 75% ethanol system soft material, granulate with 24 mesh sieves, 70 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 4:

A. get prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 4 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 4 times, merge extractive liquid, reclaims ethanol, and the extracting solution concentrate drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 125g, cyclodextrin inclusion compound 31g, microcrystalline Cellulose 140g, mannitol 120g, carboxymethyl starch sodium 50g, micropowder silica gel 5g, low-substituted hydroxypropyl cellulose 25g, the about 180ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 24 mesh sieves, 70 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 5:

A. get prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata extracting in water 1 time extracted 4 hours, and the aqueous solution of merge extractive liquid, and above-mentioned collection concentrates; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 125g, cyclodextrin inclusion compound 31g, crospolyvinylpyrrolidone 140g, cross-linking sodium carboxymethyl cellulose 120g, microcrystalline Cellulose 50g, magnesium stearate 50g, lactose 25g, 5% polyvinylpyrrolidone-30% alcoholic solution 110ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, lactose are mixed, with 5% polyvinylpyrrolidone-30% alcoholic solution system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, add the magnesium stearate mixing, tabletting is made 1000.

Embodiment 6

A. get prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 3 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 149g, cyclodextrin inclusion compound 44g, crospolyvinylpyrrolidone 50g, carboxymethyl starch sodium 20g, low-substituted hydroxypropyl cellulose 60g, cross-linking sodium carboxymethyl cellulose 60g, carboxymethylcellulose calcium 30g, tween 80 30g, sorbitol 10g, fructose 10g, trehalose 5g, lactose 2g, polyethylene glycol 6000 25g, 75% alcoholic solution 180ml; Above-mentioned substance is mixed,, granulate with 20 mesh sieves with 75% alcoholic solution system soft material, 65 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, mixing, tabletting is made 1000.

Embodiment 7:

A. get prescription, recipe quantity is standby with embodiment 3;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 88g, cyclodextrin inclusion compound 25g, crospolyvinylpyrrolidone 100g, cross-linking sodium carboxymethyl cellulose 80g, low-substituted hydroxypropyl cellulose 60g, pregelatinized Starch 15g, sorbitol 39g, arabic gum 11g, xylitol 10g, magnesium stearate 25g, micropowder silica gel 20g, 15% polyvinylpyrrolidone-70% alcoholic solution 90ml; Above-mentioned substance is mixed,, granulate with 20 mesh sieves with 15% polyvinylpyrrolidone-70% alcoholic solution system soft material, 40 ℃ of vacuum drying oven cold drying, 20 mesh sieve granulate, tabletting is made 1000.

Embodiment 8:

A. get prescription, it is standby with embodiment 2 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1 time, merge extractive liquid, reclaims ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 50g, cyclodextrin inclusion compound 50g, crospolyvinylpyrrolidone 60g, cross-linking sodium carboxymethyl cellulose 60g, microcrystalline Cellulose 150g, magnesium stearate 10g, lactose 5g, 5% polyvinylpyrrolidone-40% alcoholic solution 110ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, lactose are mixed, with 5% polyvinylpyrrolidone-40% alcoholic solution system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, add the magnesium stearate mixing, tabletting is made 1000.

Embodiment 9:

A. get prescription, it is standby with embodiment 5 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 9 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 3 times of 9 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 9 times of amounts, 99% ethanol extraction 3 times, and each 0.5～5 hour, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get above-mentioned dry extract 75g, cyclodextrin inclusion compound 25g, crospolyvinylpyrrolidone 300g, cross-linking sodium carboxymethyl cellulose 100g, microcrystalline Cellulose 300g, 50% alcoholic solution 200ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose are mixed,, granulate with 18 mesh sieves with 50% alcoholic solution system soft material, 60 ℃ of vacuum drying oven cold drying, 20 mesh sieve granulate, tabletting is made 1000.

Embodiment 10:

A. get prescription, it is standby with embodiment 6 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 30% ethanol extraction 2 times, and 5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get above-mentioned dry extract 55g, cyclodextrin inclusion compound 45g, microcrystalline Cellulose 220g, magnesium stearate 20g, lactose 15g, 5% polyvinylpyrrolidonesolution solution 80ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, lactose are mixed, with 5% polyvinylpyrrolidonesolution solution system soft material, granulate with 20 mesh sieves, 80 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, add the magnesium stearate mixing, tabletting is made 1000.

Embodiment 11:

A. get prescription, recipe quantity is standby with embodiment 1;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 7 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae be with 7 times of amounts, 65% ethanol extraction 2 times, each 2 hours, merge extractive liquid,,, reclaim the ethanol concentrated extracting solution to an amount of, drying is pulverized, the dry extract fine powder;

C. get above-mentioned dry extract 72g, cyclodextrin inclusion compound 48g, crospolyvinylpyrrolidone 160g, cross-linking sodium carboxymethyl cellulose 140g, microcrystalline Cellulose 40g, magnesium stearate 40g, lactose 55g, 10% alcoholic solution 200ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, lactose are mixed, with 10% alcoholic solution system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate add the magnesium stearate mixing, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 12

A. get prescription, recipe quantity is standby with embodiment 2;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 8 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 8 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 8 times of amounts, 95% ethanol extraction 3 times, and each 4 hours, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get above-mentioned dry extract 180g, cyclodextrin inclusion compound 50g, crospolyvinylpyrrolidone 65g, carboxymethylcellulose calcium 85g, microcrystalline Cellulose 150g, micropowder silica gel 50g, glucose 25g, 5% polyvinylpyrrolidone-20% alcoholic solution 110ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, carboxymethylcellulose calcium, microcrystalline Cellulose, glucose are mixed, with 5% polyvinylpyrrolidone-20% alcoholic solution system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, add the micropowder silica gel mixing, tabletting is made 1000.

Embodiment 13

A. get prescription, it is standby with embodiment 3 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 3 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracted 0.5 hour with 3 times of amounts, 50% ethanol extraction 1 time, and merge extractive liquid, reclaims ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get above-mentioned dry extract 65g, cyclodextrin inclusion compound 10g, pregelatinized Starch 75g, maltose 80g, carboxymethyl starch sodium 50g, micropowder silica gel 25g, low-substituted hydroxypropyl cellulose 40g, the about 150ml of 55% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, pregelatinized Starch, maltose, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 55% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 14

A. get prescription, recipe quantity is standby with embodiment 6;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 5 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 75% ethanol extraction 2 times, and 4 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get above-mentioned dry extract 75g, cyclodextrin inclusion compound 20g, microcrystalline Cellulose 120g, mannitol 50g, carboxymethyl starch sodium 110g, micropowder silica gel 8g, low-substituted hydroxypropyl cellulose 20g, the about 165ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 15

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 6 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 1.5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, concentrate, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 2 times with 80% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get above-mentioned dry extract 95g, cyclodextrin inclusion compound 40g, microcrystalline Cellulose 68g, mannitol 142g, carboxymethyl starch sodium 70g, micropowder silica gel 14g, low-substituted hydroxypropyl cellulose 40g, the about 200ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 16

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, tangerine, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 3 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata extracting in water 1 time, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, concentrate, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 3 times with 50% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get above-mentioned dry extract 105g, cyclodextrin inclusion compound 10g, mannitol 90g, carboxymethyl starch sodium 90g, micropowder silica gel 10g, low-substituted hydroxypropyl cellulose 45g, water 120ml; Above-mentioned cyclodextrin inclusion compound, dry extract, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, and water system soft material is granulated, and tabletting is made 1000.

Embodiment 17

A. get prescription, recipe quantity is standby with embodiment 4;

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, tangerine, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 8 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata extracting in water 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, concentrate, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get above-mentioned dry extract 66g, cyclodextrin inclusion compound 24g, carboxymethyl starch sodium 130g, Polyethylene Glycol 24g, cross-linking sodium carboxymethyl cellulose 108g, the about 75ml of 45% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, mannitol, carboxymethyl starch sodium, Polyethylene Glycol, cross-linking sodium carboxymethyl cellulose are mixed in mixing channel,, granulate with 20 mesh sieves with 45% ethanol system soft material, cold drying, granulate, tabletting is made 1000.

Embodiment 18

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, tangerine, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 8 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata adds 3.5 times of water gagings and extracts 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, concentrate, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get above-mentioned dry extract 105g, cyclodextrin inclusion compound 15g, microcrystalline Cellulose 130g, mannitol 110g, crospolyvinylpyrrolidone 103g, micropowder silica gel 7g, low-substituted hydroxypropyl cellulose 30g, the about 150ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, crospolyvinylpyrrolidone, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 19

A. get prescription, recipe quantity is standby with embodiment 1;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 4 times of 10 times of amounts, and each 5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 10 times of amounts, 99% ethanol extraction 4 times, and each 4 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 105g, cyclodextrin inclusion compound 51g, crospolyvinylpyrrolidone 140g, cross-linking sodium carboxymethyl cellulose 150g, microcrystalline Cellulose 20g, lactose 50g, 8% polyvinylpyrrolidone-20% alcoholic solution 110ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, lactose are mixed, with 8% polyvinylpyrrolidone-20% alcoholic solution system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 20

A. get prescription, recipe quantity is standby with embodiment 3;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 10 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2 times of amounts, 30% ethanol extraction 3 times, and each 2 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 135g, cyclodextrin inclusion compound 21g, crospolyvinylpyrrolidone 260g, sorbitol 50g, 2% polyvinylpyrrolidone-80% alcoholic solution 110ml; Above-mentioned cyclodextrin inclusion compound, dry extract, crospolyvinylpyrrolidone, sorbitol are mixed,, granulate with 20 mesh sieves with 2% polyvinylpyrrolidone-80% alcoholic solution system soft material, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate add the magnesium stearate mixing, tabletting is made 1000.

Embodiment 21

A. get prescription, recipe quantity is standby with embodiment 4;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 1 times of amount; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 9 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 7 times of amounts, 80% ethanol extraction 2 times, and each 1 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 50g, cyclodextrin inclusion compound 3g, crospolyvinylpyrrolidone 60g, carboxymethyl starch sodium 60g, low-substituted hydroxypropyl cellulose 60g, cross-linking sodium carboxymethyl cellulose 60g, carboxymethylcellulose calcium 30g, tween 80 30g, sorbitol 10g, trehalose 5g, lactose 2g, polyethylene glycol 6000 25g, 65% alcoholic solution 180ml; Above-mentioned substance is mixed,, granulate with 20 mesh sieves with 65% alcoholic solution system soft material, cold drying, 24 mesh sieve granulate, mixing, tabletting is made 1000.

Embodiment 22

A. get prescription, recipe quantity is standby with embodiment 4;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 2 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 1 time of 5 times of amounts, extract 4 hours, and the aqueous solution of merge extractive liquid, and above-mentioned collection concentrates; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 50% ethanol extraction 2 times, and each 3 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 98g, cyclodextrin inclusion compound 23g, xylitol 160g, starch 120g, carboxymethyl starch sodium 50g, micropowder silica gel 12g, low-substituted hydroxypropyl cellulose 60g, the about 150ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, xylitol, starch, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 23

A. get prescription, recipe quantity is standby with embodiment 5;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 2.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 75% ethanol extraction 2 times, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 95g, cyclodextrin inclusion compound 5g, mannitol 220g, carboxymethyl starch sodium 180g, the about 140ml of 95% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, mannitol, carboxymethyl starch sodium are mixed in mixing channel,, granulate with 20 mesh sieves with 95% ethanol system soft material, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 24

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 8 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 8 times of amounts, 95% ethanol extraction 3 times, and each 3 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 77g, cyclodextrin inclusion compound 23g, microcrystalline Cellulose 65g, mannitol 40g, carboxymethyl starch sodium 60g, micropowder silica gel 25g, low-substituted hydroxypropyl cellulose 65g, the about 90ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel,, granulate with 24 mesh sieves with 85% ethanol system soft material, cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 25

A. get prescription, recipe quantity is standby with embodiment 1;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 8 times of amounts, and each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3 times of amounts, 50% ethanol extraction 2 times, and each 0.5 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 105g, cyclodextrin inclusion compound 41g, microcrystalline Cellulose 130g, arabic gum 130g, carboxymethyl starch sodium 60g, micropowder silica gel 5g, low-substituted hydroxypropyl cellulose 15g, the about 140ml of 65% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, arabic gum, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 65% ethanol system soft material, granulate with 24 mesh sieves, 70 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 26

A. get prescription, recipe quantity is standby with embodiment 2;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 5.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 3 times of 5 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 65% ethanol extraction 2 times, and each 2 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 48g, cyclodextrin inclusion compound 13g, sorbitol 82g, xylitol 91g, carboxymethyl starch sodium 105g, micropowder silica gel 24g, low-substituted hydroxypropyl cellulose 80g, the about 75ml of 75% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, sorbitol, xylitol, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 75% ethanol system soft material, granulate, tabletting is made 1000.

Embodiment 27

A. get prescription, recipe quantity is standby with embodiment 6;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 6 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 6 times of amounts, and be each] 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrates; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 6 times of amounts, 90% ethanol extraction 2 times, and each 3 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 45g, cyclodextrin inclusion compound 5g, pregelatinized Starch 80g, arabic gum 120g, carboxymethyl starch sodium 120g, magnesium stearate 50g, low-substituted hydroxypropyl cellulose 20g, the about 200ml of 90% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, pregelatinized Starch, arabic gum, carboxymethyl starch sodium, magnesium stearate, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 90% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting, every sheet is 0.5g heavily, makes 1000.

Embodiment 28

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 6.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 3.5 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3.5 times of amounts, 55% ethanol extraction 2 times, and each 1 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 120g, cyclodextrin inclusion compound 10g, microcrystalline Cellulose 160g, crospolyvinylpyrrolidone 150g, micropowder silica gel 13g, low-substituted hydroxypropyl cellulose 80g, hydroxypropyl cellulose 25g; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, crospolyvinylpyrrolidone, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with hydroxypropyl cellulose system soft material, granulate tabletting with 20 mesh sieves, every sheet is 0.5g heavily, makes 1000.

Embodiment 29

A. get prescription, it is standby with embodiment 4 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 5.5 times of amounts, and each 1.5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4.5 times of amounts, 60% ethanol extraction 2 times, and each 2.5 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 55g, cyclodextrin inclusion compound 55g, sorbitol 85g, Lac 120g, carboxymethyl starch sodium 150g, micropowder silica gel 32g, tween 80 30g, the about 100ml of 45% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, sorbitol, Lac, carboxymethyl starch sodium, micropowder silica gel, tween 80 are mixed in mixing channel,, granulate with 18 mesh sieves with 45% ethanol system soft material, 50 ℃ of cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Embodiment 30

A. get prescription, recipe quantity is standby with embodiment 3;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 70% ethanol extraction 2 times, and each 2 hours, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 65g, cyclodextrin inclusion compound 45g, microcrystalline Cellulose 105g, citric acid 80g, carboxymethyl starch sodium 70g, micropowder silica gel 22g, low-substituted hydroxypropyl cellulose 70g, water 130ml; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, citric acid, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, and water system soft material is granulated, and tabletting is made 1000.

Embodiment 31

A. get prescription, recipe quantity is standby with embodiment 3;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 103g, cyclodextrin inclusion compound 37g, microcrystalline Cellulose 100g, mannitol 100g, crospolyvinylpyrrolidone 100g, Pulvis Talci 45g, low-substituted hydroxypropyl cellulose 30g, the about 150ml of 85% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, microcrystalline Cellulose, mannitol, crospolyvinylpyrrolidone, Pulvis Talci, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 85% ethanol system soft material, granulate, tabletting is made 1000.

Embodiment 32

A. get prescription, recipe quantity is standby with embodiment 6;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get above-mentioned dry extract 25g, cyclodextrin inclusion compound 30g, D-ribonic acid-gamma lactone 70g, starch 30g, carboxymethyl starch sodium 100g, micropowder silica gel 45g, low-substituted hydroxypropyl cellulose 50g, the about 130ml of 95% ethanol; Above-mentioned cyclodextrin inclusion compound, dry extract, D-ribonic acid-gamma lactone, starch, carboxymethyl starch sodium, micropowder silica gel, low-substituted hydroxypropyl cellulose are mixed in mixing channel, with 95% ethanol system soft material, granulate with 20 mesh sieves, 60 ℃ of vacuum drying oven cold drying, 24 mesh sieve granulate, tabletting is made 1000.

Claims

One kind have induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following weight portion proportioning raw material and dispersible tablet adjuvant:

A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, tangerine 36.70～125.40 parts, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemoniss, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 1～10 times of amount; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 1～4 time of 2～10 times of amounts, and each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2～10 times of amounts, 30～99% ethanol extractions 1～4 time, and each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder, dextrin embedding thing and dispersant adjuvant mixing granulation, tabletting;

Described dispersant adjuvant contains one or more in disintegrating agent, filler, lubricant, the binding agent;

Described disintegrating agent comprises and is selected from crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, carboxymethylcellulose calcium, the tween 80 one or more; Described filler comprises and is selected from lactose, microcrystalline Cellulose, pregelatinized Starch, mannitol, starch, erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, trehalose, D-ribose, low melting-point agarose, Lac, arabic gum, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, dextrin, the maltose one or more; Described lubricant comprises and is selected from magnesium stearate, Pulvis Talci, Polyethylene Glycol, the micropowder silica gel one or more; Described adhesive comprises and is selected from water, ethanol, polyvinylpyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, the natural clay silica gel magnalium one or more.
2. induce sweat according to claim 1, dry and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, tangerine 54.48～81.73 parts, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemoniss, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3～8 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 1～3 time of 3～8 times of amounts, and each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, and each 0.5～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder, dextrin embedding thing and dispersant adjuvant mixing granulation, tabletting.
As induce sweat, dry as described in the claim 2 and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

A. get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, tangerine 68.20 parts, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemoniss, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3.5～6 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, and each 1～2 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3.5～6 times of amounts, 55～90% ethanol extractions 2 times, and each 1～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder, dextrin embedding thing and dispersant adjuvant mixing granulation, tabletting.
As induce sweat, dry as described in the claim 3 and in dispersible tablets of Chinese medicine, it is characterized in that it is to be made by following method:

A. get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, tangerine 68.20 parts, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemoniss, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, dried tangerine peel, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection concentrated; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution concentrates; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder, dextrin embedding thing and dispersant adjuvant mixing granulation, tabletting.
5. induce sweat, dry as described in arbitrary as claim 1～4 and in dispersible tablets of Chinese medicine, it is characterized in that the disintegrating agent among the preparation method step c: dry extract fine powder and dextrin embedding thing gross weight are 0.2～4: 1; Used filler: dry extract fine powder and dextrin embedding thing gross weight are 0.1～3: 1; Used lubricant: dry extract fine powder and dextrin embedding thing gross weight are 0.05～1: 1; Used adhesive: dry extract fine powder and dextrin embedding thing gross weight are 0.05～1: 1.
6. as claimed in claim 1 induce sweat, dry and in dispersible tablets of Chinese medicine, it is characterized in that described Massa Medicata Fermentata is the Guangdong Massa Medicata Fermentata, tangerine for Exocarpium Citri Grandis, Herba Pogostemonis be Herba Pogostemonis.
7. induce sweat, dry as described in arbitrary as claim 1～6 and in the preparation method of dispersible tablets of Chinese medicine, comprise the steps:

A. it is even to get dry extract fine powder, dextrin embedding thing, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, lactose, microcrystalline cellulose mixt;

B. add polyvinylpyrrolidone-alcoholic solution and make soft material, sieve, granulate; Drying, granulate adds the magnesium stearate mixing, and tabletting promptly gets dispersible tablet.