CN102416128B - Traditional Chinese medicine composition for treating cold and relieving cough - Google Patents
Traditional Chinese medicine composition for treating cold and relieving cough Download PDFInfo
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- CN102416128B CN102416128B CN 201010502286 CN201010502286A CN102416128B CN 102416128 B CN102416128 B CN 102416128B CN 201010502286 CN201010502286 CN 201010502286 CN 201010502286 A CN201010502286 A CN 201010502286A CN 102416128 B CN102416128 B CN 102416128B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cold and relieving cough. The traditional Chinese medicine composition takes cymose buckwheat rhizome as the monarch, and is prepared from the following raw material medicines in parts by weight: 50-70 parts of cymose buckwheat rhizome, 40-60 parts of radix adenophorae, 20-40 parts of bupleurum, 20-40 parts of coltsfoot flower, 20-40 parts of radix scutellariae, 20-40 parts of radix stemonae, 10-30 parts of herba schizonepetae, 10-30 parts of aster tataricus, 10-30 parts of ledebouriella seseloides, 10-30 parts of radix peucedani, 10-30 parts of folium eriobotryae, 10-30 parts of campanulaceae, 10-30 parts of fructus schizandrae, 10-22 parts of bitter almond, 5-15 parts of pummelo peel, 5-15 parts of prepared pinellia and the like. The traditional Chinese medicine composition can be used for treating swelling and sore throat, cough or excessive phlegm and other syndromes caused by cold.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition take Rhizoma Fagopyri Dibotryis as monarch drug, particularly relate to a kind of flu cough relief traditional Chinese medicine compositions that is used for the treatment of the symptoms such as laryngopharynx swelling and pain, cough or abundant expectoration that Common Cold causes.
Background technology
Cough is disease independently, is again a symptom of multiple lung pattern disease, is mainly in autumn and winter season, belongs to clinically commonly encountered diseases and frequently-occurring disease.Due to its nosogenetic complexity, brought certain difficulty to clinical treatment.The Chinese medicine cough has abundant theory and clinical experience, and evident in efficacy.
Summary of the invention
The purpose of this invention is to provide a kind of flu cough relief traditional Chinese medicine compositions that is used for the treatment of the symptoms such as laryngopharynx swelling and pain, cough or abundant expectoration that Common Cold causes take Rhizoma Fagopyri Dibotryis as monarch drug.
For achieving the above object, technical scheme of the present invention provides a kind of flu cough relief traditional Chinese medicine compositions, and its crude drug is: Rhizoma Fagopyri Dibotryis 50-70 weight portion; Radix Adenophorae (Radix Glehniae) 40-60 weight portion; Radix Bupleuri 20-40 weight portion; Flos Farfarae 20-40 weight portion; Radix Scutellariae 20-40 weight portion; Radix Stemonae 20-40 weight portion; Herba Schizonepetae 10-30 weight portion; Radix Asteris 10-30 weight portion; Radix Saposhnikoviae 10-30 weight portion; Radix Peucedani 10-30 weight portion; Folium Eriobotryae 10-30 weight portion; Radix Platycodonis 10-30 weight portion; Fructus Schisandrae Chinensis 10-30 weight portion; Semen Armeniacae Amarum 10-22 weight portion; Exocarpium Citri Grandis 5-15 weight portion; Rhizoma Pinelliae Preparatum 5-15 weight portion;
Chinese medicine composition of the present invention, preferred crude drug is: Rhizoma Fagopyri Dibotryis 60 weight portions; Radix Adenophorae (Radix Glehniae) 50 weight portions; Radix Bupleuri 30 weight portions; Flos Farfarae 30 weight portions; Radix Scutellariae 30 weight portions; The Radix Stemonae 30 weight portions; Herba Schizonepetae 20 weight portions; Radix Asteris 20 weight portions; Radix Saposhnikoviae 20 weight portions; Radix Peucedani 20 weight portions; Folium Eriobotryae 20 weight portions; Radix Platycodonis 20 weight portions; Fructus Schisandrae Chinensis 20 weight portions; Semen Armeniacae Amarum 15 weight portions; Exocarpium Citri Grandis 10 weight portions; Rhizoma Pinelliae Preparatum 10 weight portions.
Chinese medicine composition of the present invention can be used for preparing the medicine of the symptoms such as laryngopharynx swelling and pain, cough or abundant expectoration that the treatment Common Cold causes.It can make clinical various dosage forms commonly used for above-mentioned Chinese medicine composition and any pharmaceutically acceptable carrier, as acceptable tablet, pill, capsule, granule, electuary, oral liquid, soft extract, mixture or powder clinically.Wherein preferred dosage form is soft extract.This dosage form mouthfeel is good, patient's taking convenience, and be easy to accept, and the effective substance component content is high.
According to a preferred embodiment of the invention, the invention provides a kind of flu Zhike Gao Chinese patent medicine product, its preparation method is: ten Six-elements, except the independent distillation extraction of Semen Armeniacae Amarum, all the other ten Chinese medicine of the five flavours decoct with water secondary, 2h for the first time, 1h for the second time, decocting liquid filters, filtrate merges, standing 2h gets supernatant, is concentrated into appropriate.Add refined honey, boil, let cool; Add according to this Bergeninum, CHENPI DING, Radix Glycyrrhizae fluidextract, aqua armeniacae, Mentholum alcoholic solution, add refined honey appropriate, stir evenly, and get final product.
Refined honey: Mel is put in pot, and first heating with high heat, use slow fire instead, and frequently pull floating foam and waxiness etc. out after boiling, refines to color and luster and deepen, and is when slightly strong than raw honey with its viscosity of hands sth. made by twisting, standby from fire.
Technique scheme has following advantage:
Flu cough relief traditional Chinese medicine compositions provided by the invention has to induce sweat gets rid of evils, clearing heat and moistening lung, relieving cough and resolving phlegm.The clinical laryngopharynx swelling and pain that causes for Common Cold, the diseases such as cough, abundant expectoration.Have determined curative effect, instant effect, characteristics that cure rate is high.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the flu Zhike Gao
One, formula
Rhizoma Fagopyri Dibotryis 60g Radix Adenophorae (Radix Glehniae) 50g Radix Bupleuri 30g Flos Farfarae 30g Radix Scutellariae 30g
Radix Stemonae 30g Herba Schizonepetae 20g Radix Asteris 20g Radix Saposhnikoviae 20g Radix Peucedani 20g
Folium Eriobotryae 20g Radix Platycodonis 20g Fructus Schisandrae Chinensis 20g Semen Armeniacae Amarum 15g Exocarpium Citri Grandis 10g
Rhizoma Pinelliae Preparatum 10g Bergeninum 1.5g Mentholum 1g CHENPI DING 1ml Radix Glycyrrhizae fluidextract 1ml
Refined honey is appropriate.
Two, method for making:
Front ten Six-elements, except the independent distillation extraction of Semen Armeniacae Amarum, all the other ten Chinese medicine of the five flavours decoct with water secondary, 2h for the first time, 1h for the second time, decocting liquid filters, and filtrate merges, and standing 2h gets supernatant, is concentrated into appropriate.Add refined honey, boil, let cool; Add according to this Bergeninum, CHENPI DING, Radix Glycyrrhizae fluidextract, aqua armeniacae, Mentholum alcoholic solution, add refined honey to 1000ml, stir evenly, and get final product.
Refined honey: Mel is put in pot, and first heating with high heat, use slow fire instead, and frequently pull floating foam and waxiness etc. out after boiling, refines to color and luster and deepen, and is when slightly strong than raw honey with its viscosity of hands sth. made by twisting, standby from fire.
Three, character
This product is extremely light red brown paste liquid of yellowish-brown, and being long placed in to have trace muddy, and gas is fragrant, sweet and sour, little hardship, cool.
Four, differentiate
(1) get this product 30ml, add chloroform and extract 2 times, each 10ml, combined chloroform liquid is put water bath method, adds chloroform 1ml dissolving, as need testing solution.Another depletion Semen Fagopyri Esculenti control medicinal material 3.5g adds the chloroform dipping and spends the night, and filters, and the filtrate evaporate to dryness adds chloroform 1ml dissolving, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, take chloroform-methanol (19: 1) as developing solvent, launch, take out, dry, spray is heated to the speckle colour developing clear with 10% ethanol solution of sulfuric acid.In the test sample chromatograph, with control medicinal material chromatograph corresponding position on, the speckle of aobvious same color.
(2) get this product 30ml, add 7% sulphuric acid ethanol-water (1: 3) 20ml, reflux 1 hour, let cool, use chloroform extraction 2 times, each 20ml, combined chloroform liquid, add water 30ml washing, discard washing liquid, the chloroform anhydrous sodium sulfate dehydration, filter, filtrate evaporate to dryness, residue add the 1ml dissolve with methanol, as need testing solution.Separately get Radix Platycodonis control medicinal material 3.5g, be made in the same way of control medicinal material solution.Draw each 10 μ l of above-mentioned two kinds of solution according to thin layer chromatography (appendix VI B of Chinese Pharmacopoeia version in 2005) test, put respectively on same silica gel plate G lamellae, take chloroform-ether (1: 1) as developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and 105 ℃ to be heated to speckle colour developing clear.In the test sample chromatograph, with control medicinal material chromatograph corresponding position on, the mottle of aobvious same color.
Five, check
Relative density should be not less than 1.30 (appendix VII A of Chinese Pharmacopoeia version in 2010).
Other should meet every regulation under the soft extract item (I F of Chinese Pharmacopoeia version appendix in 2010).
Six, function cures mainly
Induce sweat and get rid of evils, clearing heat and moistening lung, relieving cough and resolving phlegm.Be used for the laryngopharynx swelling and pain that Common Cold causes, the diseases such as cough, abundant expectoration.
Seven, usage and dosage
Oral, a 10～15ml, three times on the one.
Eight, specification
The 120ml/ bottle; Sealing is kept in Dark Place.
The clinical practice result of test example 1: embodiment 1
1, effect and purposes are induced sweat and are got rid of evils, preventing phlegm from forming and stopping coughing.Be used for the diseases such as laryngopharynx swelling and pain cough that Common Cold causes.
2, clinical data is observed patient's 567 examples altogether, and the oldest 72 years old, minimum 4 years old, average 32 years old.The course for the treatment of the longest 20d, the shortest 3d.
3, Therapeutic Method and course of therapy group are oral with this product, each 10mL, and every day 3 times, 5d was 1 course for the treatment of; The oral CHUANBEI PIPA GAO of matched group, each 10mL, every day 3 times, 5d was 1 course for the treatment of.
The CHUANBEI PIPA GAO that matched group adopts is capital of a country Nian Ci Um MILIAN CHUANBEI PIPA GAO, main component: Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Adenophorae (Radix Glehniae), Poria cum Radix Pini, dried tangerine peel, Radix Platycodonis, Rhizoma Pinelliae Preparatum, Radix Schisandrae Bicoloris, Semen Trichosanthis, Radix Polygalae, Semen Armeniacae Amarum, Rhizoma Zingiberis Recens, Herba Menthae, Mel.
4, criterion of therapeutical effect and result
4.1 criterion of therapeutical effect
With the laryngopharynx swelling and pain that Common Cold causes, coughing is indication.Recovery from illness: transference cure.Effectively: remission, attack times reduces; Invalid: symptom is without change.
4.2 results and analysis
Treatment group: the laryngopharynx swelling and pain that flu causes, cough 567 examples are wherein cured 356 examples (62.8%), effective 189 examples (33.3%), invalid 22 examples (3.95%), total effective rate is 96.1%.
Matched group: the laryngopharynx swelling and pain that flu causes, cough 285 examples are wherein cured 62 examples (21.75%), effective 151 examples (52.98%), invalid 72 examples (25.27%), total effective rate is 80.73%.
Embodiment 2: the flu cough pill
Adopt following formula, the aforesaid extraction step of preparation method is with embodiment 1, after with extract routinely formulation method make pill, as water-honeyed pill.
Formula:
Rhizoma Fagopyri Dibotryis 50g Radix Adenophorae (Radix Glehniae) 40g Radix Bupleuri 20g Radix Stemonae 40g Flos Farfarae 40g
Radix Scutellariae 20g Herba Schizonepetae 30g Radix Asteris 10g Radix Saposhnikoviae 30g Radix Peucedani 10g
Folium Eriobotryae 30g Radix Platycodonis 10g Fructus Schisandrae Chinensis 10g Semen Armeniacae Amarum 22g Exocarpium Citri Grandis 15g
Rhizoma Pinelliae Preparatum 5g.
Embodiment 3: the flu cough-stopping granule
Adopt following formula, the aforesaid extraction step of preparation method is with embodiment 1, after with extract formulation method granulation agent routinely.
Formula:
Rhizoma Fagopyri Dibotryis 70g Radix Adenophorae (Radix Glehniae) 60g Radix Bupleuri 40g Radix Stemonae 20g Flos Farfarae 20g
Radix Scutellariae 40g Herba Schizonepetae 10g Radix Asteris 30g Radix Saposhnikoviae 10g Radix Peucedani 30g
Folium Eriobotryae 10g Radix Platycodonis 30g Fructus Schisandrae Chinensis 30g Semen Armeniacae Amarum 10g Exocarpium Citri Grandis 5g
Rhizoma Pinelliae Preparatum 15g.
The above is only the preferred embodiment of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. the flu cough relief traditional Chinese medicine compositions take Rhizoma Fagopyri Dibotryis as monarch drug, is characterized in that, its crude drug is: Rhizoma Fagopyri Dibotryis 50-70 weight portion; Radix Adenophorae (Radix Glehniae) 40-60 weight portion; Radix Bupleuri 20-40 weight portion; Flos Farfarae 20-40 weight portion; Radix Scutellariae 20-40 weight portion; Radix Stemonae 20-40 weight portion; Herba Schizonepetae 10-30 weight portion; Radix Asteris 10-30 weight portion; Radix Saposhnikoviae 10-30 weight portion; Radix Peucedani 10-30 weight portion; Folium Eriobotryae 10-30 weight portion; Radix Platycodonis 10-30 weight portion; Fructus Schisandrae Chinensis 10-30 weight portion; Semen Armeniacae Amarum 10-22 weight portion; Exocarpium Citri Grandis 5-15 weight portion; Rhizoma Pinelliae Preparatum 5-15 weight portion.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, its crude drug is: Rhizoma Fagopyri Dibotryis 60 weight portions; Radix Adenophorae (Radix Glehniae) 50 weight portions; Radix Bupleuri 30 weight portions; Flos Farfarae 30 weight portions; Radix Scutellariae 30 weight portions; The Radix Stemonae 30 weight portions; Herba Schizonepetae 20 weight portions; Radix Asteris 20 weight portions; Radix Saposhnikoviae 20 weight portions; Radix Peucedani 20 weight portions; Folium Eriobotryae 20 weight portions; Radix Platycodonis 20 weight portions; Fructus Schisandrae Chinensis 20 weight portions; Semen Armeniacae Amarum 15 weight portions; Exocarpium Citri Grandis 10 weight portions; Rhizoma Pinelliae Preparatum 10 weight portions.
3. the application of the described Chinese medicine composition of claim 1 or 2 in the medicine of laryngopharynx swelling and pain, cough or abundant expectoration that preparation treatment Common Cold causes.
4. a flu cough relief traditional Chinese medicine preparation, is characterized in that, it is comprised of the described Chinese medicine composition of claim 1 or 2 and pharmaceutically acceptable carrier.
5. Chinese medicine preparation as claimed in claim 4, is characterized in that, described preparation is acceptable tablet, pill, capsule, granule, electuary, oral liquid, soft extract, syrup, mixture clinically.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that, it is soft extract.
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| CN 201010502286 CN102416128B (en) | 2010-09-28 | 2010-09-28 | Traditional Chinese medicine composition for treating cold and relieving cough |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671083B (en) * | 2012-05-02 | 2014-02-12 | 张燕 | Infant cough-relieving and phlegm-reducing medicine |
| CN102688354B (en) * | 2012-06-14 | 2014-02-12 | 李良 | Traditional Chinese medicine decoction of schizonepeta for treating cough and preparation method thereof |
| CN105194265A (en) * | 2014-06-26 | 2015-12-30 | 梁军 | Drug for treating cough |
| CN104524381B (en) * | 2014-12-19 | 2015-11-04 | 吕铁军 | A kind of medicine and preparation method being used for the treatment of pneumonia |
| CN106562957B (en) * | 2015-10-08 | 2019-02-12 | 中国科学院微生物研究所 | Application of the compound AJ-2 in the drug that preparation treats or prevents influenza virus |
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| CN1788782A (en) * | 2004-12-16 | 2006-06-21 | 神奇梵净山铜仁药业有限公司 | Loquat leaf extractum for nourishing lung and relieving cough |
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