CN102416093B - Chinese herbal composition capable of diminishing inflammation and clearing throat - Google Patents
Chinese herbal composition capable of diminishing inflammation and clearing throat Download PDFInfo
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- CN102416093B CN102416093B CN 201010502288 CN201010502288A CN102416093B CN 102416093 B CN102416093 B CN 102416093B CN 201010502288 CN201010502288 CN 201010502288 CN 201010502288 A CN201010502288 A CN 201010502288A CN 102416093 B CN102416093 B CN 102416093B
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Abstract
The invention discloses a Chinese herbal composition which uses golden buckwheat as a monarch drug and is capable of diminishing inflammation and clearing throat. Bulk drugs for the composition comprise, by weight, 80 to 120 parts of radix scrophulariae, 60 to 100 parts of ophiopogon root, 80 to 120 parts of Japanese honeysuckle stem, 60 to 100 parts of belamcandin, 60 to 100 parts of root of large-flowered skullcap, 60 to 150 parts of golden buckwheat, 60 to 80 parts of rehmanniae radix, 80 to 120 parts of laggera pterodonta, 60 to 100 parts of gypsum and 2 to 4 parts of menthol. The Chinese herbal composition can be used for treating abscess of throat caused by acute tonsillitis, angor, upper respiratory tract infection or the like.
Description
Technical field
The present invention relates to a kind of is the Chinese medicine composition of monarch drug with the Rhizoma Fagopyri Dibotryis, particularly relates to a kind of sharp larynx Chinese medicine composition of antiinflammatory that is used for the treatment of the laryngopharynx swelling and pain that acute tonsillitis, angina or upper respiratory tract infection etc. cause.
Background technology
Acute tonsillitis, angina are one of specialty of pharyngolaryngology commonly encountered diseases.Due to illness because of complicated, subjective symptom more than objective sign, clinical difficult its curative effect of estimating, western medical treatment only limits to topical application and the whole body of antibacterials and iodine molecule antibacterial etc. and uses.It is for oral administration that the traditional Chinese medical science previously is partial to cold and cool medicine composition prescription with heat-clearing and toxic substances removing more, and curative effect is relatively poor.We use on the basis of Chinese medicine acute tonsillitis, angina experience for many years in summary, have developed " the sharp larynx oral liquid of antiinflammatory ", through clinical verification, and satisfactory effect.
Summary of the invention
The purpose of this invention is to provide a kind of sharp larynx Chinese medicine composition of antiinflammatory that is used for the treatment of the laryngopharynx swelling and pain that acute tonsillitis, angina or upper respiratory tract infection etc. cause.
For achieving the above object, it is the sharp larynx Chinese medicine composition of antiinflammatory of monarch drug with the Rhizoma Fagopyri Dibotryis that technical scheme of the present invention provides a kind of, and its crude drug is: Rhizoma Fagopyri Dibotryis 100-150 weight portion; Herba laggera 80-120 weight portion; Radix Scrophulariae 80-120 weight portion; Caulis Lonicerae 80-120 weight portion; Radix Ophiopogonis the 60-100 weight portion; Rhizoma Belamcandae 60-100 weight portion; Radix Scutellariae 60-100 weight portion; Radix Rehmanniae 60-80 weight portion; Gypsum Fibrosum 60-100 weight portion.
Chinese medicine composition of the present invention, preferred crude drug is: Rhizoma Fagopyri Dibotryis 125 weight portions; Herba laggera 100 weight portions; Radix Scrophulariae 100 weight portions; Caulis Lonicerae 100 weight portions; Radix Ophiopogonis 80 weight portion; Rhizoma Belamcandae 80 weight portions; Radix Scutellariae 80 weight portions; The Radix Rehmanniae 80 weight portions; Gypsum Fibrosum 80 weight portions.
Chinese medicine composition of the present invention can be used for preparing the medicine of the laryngopharynx swelling and pain that treatment acute tonsillitis, angina or upper respiratory tract infection causes.It can make clinical various dosage forms commonly used for above-mentioned Chinese medicine composition and any pharmaceutically acceptable carrier, as tablet, pill, capsule, granule, electuary, oral liquid, syrup, mixture or powder etc.Wherein preferred dosage form is oral liquid.Its clinical taking convenience, production technology is simple.
According to a preferred embodiment of the invention a, the invention provides the sharp larynx oral liquid of a kind of antiinflammatory Chinese patent medicine product, its preparation method is, above-mentioned 9 flavor crude drug are ground into coarse powder, decoct with water 3 times, add water triplication, qdx, one times of amount successively, the 1st decoction 2 hours, the 2nd and 3 time each 1 hour, filtrate merges, and filters, and filtrate adds ethanol to be made and contain the alcohol amount and reach 60%, leave standstill, filter, filtering residue washs with low amounts of water, and washing liquid is incorporated in the filtrate, concentrating under reduced pressure, add sodium benzoate and Mentholum alcoholic solution, stir evenly, filter, get filtrate, add syrup, stir evenly, namely.
Technique scheme has following advantage:
The sharp larynx Chinese medicine composition of antiinflammatory provided by the invention has the effect of yin nourishing, moistening and cleaning throat, heat clearing and inflammation relieving detoxifcation.Clinical in acute tonsillitis, angina, the laryngopharynx swelling and pain that upper respiratory tract infection causes.Have determined curative effect, instant effect, characteristics that cure rate is high.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the sharp larynx oral liquid of antiinflammatory
One, prescription
Rhizoma Fagopyri Dibotryis 125g, Herba laggera 100g, Radix Scrophulariae 100g, Caulis Lonicerae 100g, Radix Ophiopogonis 80g, Rhizoma Belamcandae 80g, Radix Scutellariae 80g, Radix Rehmanniae 80g, Gypsum Fibrosum 80g, Mentholum 3g.
Two, method for making
More than 9 the flavor, be ground into coarse powder, decoct with water 3 times, add water triplication, qdx, one times of amount successively, decocted 2 hours for the 1st time, the 2nd and 3 time each 1 hour, filtrate merged, and filtered, filtrate adds ethanol to be made and contains alcohol amount and reach 60% (percentage by weight), placed 24 hours, and filtration, filtering residue washs with low amounts of water, washing liquid is incorporated in the filtrate, is evaporated to about 1000ml, adds sodium benzoate 3g and Mentholum alcoholic solution, stir evenly, filter, get filtrate, add simple syrup and make into 1000ml, stir evenly, namely.
Three, character
This product is tan thick liquid, and it is sweet to distinguish the flavor of, little hardship.
Four, differentiate
(1) get this product 10ml, add methanol 25ml, supersound process 20 minutes filters, and filtrate evaporate to dryness, residue add methanol 4ml makes dissolving, as need testing solution.Depletion Semen Fagopyri Esculenti control medicinal material 1g shines medical material solution in pairs with legal system in addition.Get the epicatechin reference substance again, add methanol and make the solution that every 1ml contains 1mg, in contrast product solution.According to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2010) test, draw each 5 μ l of need testing solution 10 μ l, control medicinal material solution and reference substance solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-methanol-formic acid (1: 2: 0.2: 0.1) be developing solvent, launch, take out, dry, spray is with 25% phosphomolybdic acid ethanol solution, and it is clear to be heated to the speckle colour developing at 110 ℃.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get this product 10ml, extract 2 times with the ethyl acetate jolting, each 10ml discards acetic acid ethyl fluid, and the water saturated n-butyl alcohol jolting of reuse is extracted 2 times, and each 10ml merges n-butyl alcohol liquid, and evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Radix Scrophulariae control medicinal material 1g, adds water saturated n-butyl alcohol 20ml supersound process 30 minutes, filters, and filtrate evaporate to dryness, residue add methanol 2ml makes dissolving, in contrast medical material solution.According to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2010) test, draw above-mentioned two kinds of solution, 2 μ l, put respectively on same silica gel g thin-layer plate, be developing solvent with chloroform-methanol (13: 2), launch, take out, dry, spray is with vanillin sulphuric acid test solution, and it is clear to be heated to the speckle colour developing.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
Five, check
Relative density: should be not less than 1.10 (an appendix VII of Chinese Pharmacopoeia version in 2010 A).
PH value: (" appendix VIB of Chinese pharmacopoeia version in 2010) the appendix VII G that should be 3.5～5.5).
Other: should meet every regulation relevant under the oral liquid item (an appendix I of Chinese Pharmacopoeia version in 2005 J).
Six, function cures mainly
Yin nourishing, moistening and cleaning throat, heat clearing and inflammation relieving detoxifcation.Be used for acute tonsillitis, angina, the laryngopharynx swelling and pain that upper respiratory tract infection causes.
Seven, usage and dosage
Oral or contain a moment slightly in isthmus faucium portion, swallow slowly again, then drug effect is better, each 10～20ml that is grown up, every day 3～4 times, or follow the doctor's advice.
Eight, specification
The 100ml/ bottle; Sealing, shading, shady and cool place preserves.
The clinical practice result of the oral liquid of test example 1: embodiment 1
1, clinical data is observed patient's 69 examples altogether, male's 37 examples, women's 32 examples, the oldest 76 years old, minimum 17 years old, average 32 years old.The course for the treatment of the longest 15d, the shortest 3d.
2, Therapeutic Method and course of therapy group are oral with this product, each 10mL, and every day 3 times, 5d was 1 course for the treatment of; Matched group qinghouyan mixture (Chinese Pharmacopoeia version in 2010: qinghouyan mixture; Composition: Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae, Fructus Forsythiae, Radix Scutellariae), each 10mL, every day 3 times, 3d was 1 course for the treatment of.
3, criterion of therapeutical effect and result
3.1 criterion of therapeutical effect
Be indication with acute tonsillitis, angina.Recovery from illness: transference cure.Effectively: remission, attack times reduces; Invalid: symptom does not have change.
3.2 therapeutic outcome
The treatment group: acute tonsillitis 69 examples, wherein cure 49 examples (71.01%), effective 15 examples (21.73%), invalid 5 examples (7.25%), total effective rate is 92.746%.
Matched group: acute tonsillitis 53 examples, wherein cure 34 examples (64.15%), effective 9 examples (16.98%), invalid 10 examples (18.87%), total effective rate is 81.13%.
Embodiment 2: the sharp lozenge of antiinflammatory
Adopt following prescription, the aforesaid extraction step of preparation method is with embodiment 1, after with extract routinely formulation method make tablet.
Prescription:
Rhizoma Fagopyri Dibotryis 150g, Herba laggera 120g, Radix Scrophulariae 80g, Caulis Lonicerae 80g, Radix Ophiopogonis 100g, Rhizoma Belamcandae 100g, Radix Scutellariae 60g, Radix Rehmanniae 60g, Gypsum Fibrosum 60g, Mentholum 2g.
Embodiment 3: the sharp larynx capsule of antiinflammatory
Adopt following prescription, the aforesaid extraction step of preparation method is with embodiment 1, after with extract after formulation method incapsulates routinely namely.
Prescription:
Rhizoma Fagopyri Dibotryis 100g, Herba laggera 80g, Radix Scrophulariae 120g, Caulis Lonicerae 120g, Radix Ophiopogonis 60g, Rhizoma Belamcandae 60g, Radix Scutellariae 100g, Radix Rehmanniae 80g, Gypsum Fibrosum 100g, Mentholum 4g.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (8)
1. one kind is the sharp larynx Chinese medicine composition of antiinflammatory of monarch drug with the Rhizoma Fagopyri Dibotryis, it is characterized in that, is prepared from by following component: Rhizoma Fagopyri Dibotryis 100-150 weight portion; Herba laggera 80-120 weight portion; Radix Scrophulariae 80-120 weight portion; Caulis Lonicerae 80-120 weight portion; Radix Ophiopogonis the 60-100 weight portion; Rhizoma Belamcandae 60-100 weight portion; Radix Scutellariae 60-100 weight portion; Radix Rehmanniae 60-80 weight portion; Gypsum Fibrosum 60-100 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that, is prepared from by following component: Rhizoma Fagopyri Dibotryis 125 weight portions; Herba laggera 100 weight portions; Radix Scrophulariae 100 weight portions; Caulis Lonicerae 100 weight portions; Radix Ophiopogonis 80 weight portion; Rhizoma Belamcandae 80 weight portions; Radix Scutellariae 80 weight portions; The Radix Rehmanniae 80 weight portions; Gypsum Fibrosum 80 weight portions.
3. claim 1 or the 2 described Chinese medicine compositions application in the medicine of the laryngopharynx swelling and pain that preparation treatment acute tonsillitis, angina or upper respiratory tract infection cause.
4. the sharp larynx Chinese medicine preparation of an antiinflammatory is characterized in that, is made up of claim 1 or 2 described Chinese medicine compositions and pharmaceutically acceptable carrier.
5. Chinese medicine preparation as claimed in claim 4 is characterized in that, described preparation is acceptable tablet, pill, capsule, electuary, syrup, mixture or powder clinically.
6. Chinese medicine preparation as claimed in claim 5 is characterized in that, described electuary is granule.
7. Chinese medicine preparation as claimed in claim 5 is characterized in that, it is oral liquid.
8. the preparation method of the described Chinese medicine preparation of claim 7 is characterized in that, described 9 flavor crude drug are ground into coarse powder, decoct with water 3 times, add water triplication, qdx, one times of amount successively, the 1st decoction 2 hours, the 2nd and 3 time each 1 hour, filtrate merges, and filters, and filtrate adds ethanol to be made and contain the alcohol amount and reach 60%, leaves standstill, filter, filtering residue washs with low amounts of water, and washing liquid is incorporated in the filtrate, concentrating under reduced pressure, add sodium benzoate and Mentholum alcoholic solution, stir evenly, filter, get filtrate, add syrup, stir evenly, namely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010502288 CN102416093B (en) | 2010-09-28 | 2010-09-28 | Chinese herbal composition capable of diminishing inflammation and clearing throat |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010502288 CN102416093B (en) | 2010-09-28 | 2010-09-28 | Chinese herbal composition capable of diminishing inflammation and clearing throat |
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| CN102416093A CN102416093A (en) | 2012-04-18 |
| CN102416093B true CN102416093B (en) | 2013-08-14 |
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| CN103461929B (en) * | 2013-09-09 | 2015-02-11 | 南陵县葛业协会 | Seasoning packet for preserving cool and refreshing salted eggs |
| CN105250779A (en) * | 2015-11-13 | 2016-01-20 | 刘翠容 | Traditional Chinese medicine composition for treating lung and stomach heat excess type chronic tonsillitis |
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| CN1270762C (en) * | 2004-08-27 | 2006-08-23 | 唐秋海 | Cough stopping and asthma relieving medicine and its preparation |
| CN101732561B (en) * | 2009-12-29 | 2013-07-24 | 重庆精鼎药材科技开发有限公司 | Health-care medicine used for preventing and treating chronic pharyngitis and preparation method thereof |
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Owner name: YUNNAN KANGCHUANG BIO-MEDICINE TECHNOLOGY INCUBATI Free format text: FORMER OWNER: GELIKANG BIOLOGICAL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD., QUJING ECONOMI Effective date: 20150212 |
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Effective date of registration: 20150212 Address after: 655000 No. 51 West Swiss Road, Qilin District, Yunnan, Qujing Patentee after: YUNNAN KANGCHUANG BIOPHARMACEUTICAL TECHNOLOGY INCUBATION CO., LTD. Address before: 655000 No. 1 Garden Road, Yunnan, Qujing Patentee before: Gelikang Biological Science and Technology Development Co., Ltd., Qujing Economi |
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Effective date of registration: 20211025 Address after: 655000 No.1 Yuanyuan Road, Qilin District, Qujing City, Yunnan Province Patentee after: QUJING NO.1 PEOPLE'S Hospital Address before: 655000 No. 51, Ruihe West Road, Qilin District, Qujing City, Yunnan Province Patentee before: YUNNAN KANGCHUANG BIOLOGICAL MEDICAL TECHNOLOGY HATCHING Co.,Ltd. |