CN107635573A - Atopic dermatitis Chinese medicine preparation, preparation method and its usage - Google Patents
Atopic dermatitis Chinese medicine preparation, preparation method and its usage Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
A kind of atopic dermatitis Chinese medicine preparation, including 0.5 part of 10 parts of Normal juice of Morinda Citrifolia juice fermentation, 1 part of stinkweed leaf juice and the thyme leaf juice calculated according to volume, Morinda Citrifolia juice fermentation Normal juice is to dry the Noni fruit cleaning of fresh mature, placed 3 months in the closed container at a temperature of 250 DEG C~350 DEG C, make its spontaneous fermentation, filter and Noni fruit fermentation Normal juice is made.The preparation combines the property of medicine feature of Morinda Citrifolia juice, stinkweed leaf and thyme leaf, the property of medicine such as invigorating the spleen, raising immunologic function, promoting the circulation of qi excreting dampness, wind-dispelling, promoting blood circulation, calm, subdhing swelling and detoxicating, sterilization, antibacterium, antiviral, antifungi, toxin expelling, cell tissue reparation activation and its regeneration function are merged, not only took stopgap measures but also consolidated, manufactured medicine for external application can effectively treat the skin disease chronic diseases such as the atopic dermatitis of asthma initiation.
Description
Technical field
The present invention relates to atopic dermatitis Chinese medicine preparation, preparation method and its usage, and it is the skins such as treatment atopic dermatitis
The property of medicine feature of skin disease chronic disease active drug, its beautiful fruit juice of Zong He Re, stinkweed leaf and thyme leaf, manufactured medicine for external application are effective
The skin disease chronic diseases such as the atopic dermatitis that asthma triggers are treated, a kind of possible approach is provided for radical cure atopic dermatitis.
Background technology
Atopic dermatitis (atopic dermatitis, AD) is a kind of chronic, recurrent, inflammatory dermatoses.The disease is sent out
Patient includes each age level, but the generally initial hair patient before infancy, 1 years old accounts for the 50% of all patients, and part is suffered from
Person's state of an illness can delay adult.In developed country, sick child child's illness rate may be up to 10%~20%.It is special over China, 20 years
The illness rate of answering property dermatitis is also being gradually risen, and District of Shanghai epidemiology survey in 2012 is shown, 3~6 years old child morbidity rate
Up to 8.3%, urban children illness rate is significantly higher than rural area.
The factor relations such as the morbidity of atopic dermatitis and h and E are close.Father and mother degree family member has anaphylaxis disease
Medical history person, suffer from the sick probability and dramatically increase.Statistics shows that about 60% patient has family's allergies, as having in family member
Atopic dermatitis, allergic asthma, allergic rhinitis, allergic conjunctivitis etc..Some patientss particularly severe atopic dermatitis
There can be serum total Ig E rise, about 40%~60% patient has periphery blood eosinophils rise.Some patientss have obvious different
Kind protein allergies, such as to part of the food albumen (meat, egg, milk, nut) or inhalation (inhalatio) (dust mite, dermatophagoides pteronyssinus etc.) allergy.
Inherent cause mainly influences skin barrier function and immunologic balance, and this patient often has what is mediated based on Th2 to exempt from
Epidemiology is abnormal, the problems such as also reducing or lack just like silk polyprotein in epidermis, weakens or destroys skin barrier function.Environmental factor
Including environmental change, lifestyle change, overwass, infector and allergen etc..In addition, psychological factor (such as nervous,
Anxiety, depression etc.) also play certain effect in the morbidity of atopic dermatitis.
The definite pathogenesis of atopic dermatitis is unclear.It is commonly considered as on the basis of inherent cause, due to allergen
Into with Microorganism colonization (such as staphylococcus aureus and chlosma), form cutaneous immunisation abnormal response and inflammation, trigger
Fash and itch, and scytitis can further be aggravated with pessimal stimulations such as overwasses by scratching.
The clinical manifestation of atopic dermatitis is varied, it is most basic be characterized in dry skin, chronic eczema sample dermatitis and
Violent itch.The disease is most of initial in infantile period, can partly betide children and adulthood.Infancy (is born to 2 years old)：
Infantile eczema is shown as, is distributed in two cheeks, forehead and scalp more, fash can be dried or oozed out.Childhood (2~12 years old)：It is more
Developed by infancy, can also occurred without infancy.Side is stretched occurred in fossa cubitalis, popliteal nest and shank, with subacute
It is main performance with chronic dermatitis, fash often dries plumpness, there is obvious lichenification.Young and adulthood (more than 12 years old)：
Skin lesion with childhood it is similar, also based on subacute and chronic dermatitis, occur mainly in the positions such as fossa cubitalis, popliteal nest, throat, also may be used
Trunk, four limbs, face, the back of the hand are betided, it is most of to can also appear as pruigo in dry, hypertrophica dermatitis infringement, some patientss
Sample fash.
Atopic dermatitis is chronic relapsing disease, up to the present, medically also without the medicine that can be effected a radical cure completely
Or method, the purpose for the treatment of are only to alleviate or eliminate clinical symptoms.Doctor trained in Western medicine is more to AD treatment method, but side effect is big,
Recurrence rate is high in a short time.Atopic dermatitis medicine includes antihistamine, and oral antihistamines help to mitigate caused dermatitis
Disease itch.Some popular antihistamines include：Loratadine, Cetirizine Hydrochloride, fexofenadine etc..Inner Yong Kang Group amine medicines
Major side effects have the normal See whats first generation Kang Group Woven amine of (but unlimited what) drowsiness (More) and resistance phenomenon, the main of external application secondary make
With those Drug Wu Productivity Sheng quick anti-Should of Over of Shi Pi Skin Right, such as eruption.
In most cases, the treatment of atopic dermatitis is completed by the application in external preparation for skin medicine.These external applications
Medicine mainly has：Xian Pi Quality hormones on glucocorticoid (You Ming Kidney) ointment or creme, glucocorticoid be by adrenal cortex beam
Shape band secretion a kind of steroid hormone, also can be artificial synthesized by chemical method, major product include hydrocortisone, fill in rice
Pine, betamethasone, beclomethasone etc., glucocorticoid have very powerful antiinflammatory action under larger dose, can protect body not
Encroached on by inflammatory reaction, while immune response, Hemorrhagic shock can also be suppressed.But glucocorticoid has obvious side effect, meeting
Cause metabolic disorder, cause if fat accumulation is in face and belly, thinning of skin, osteoporosis, hyperglycaemia, high fat of blood, influence life
The side effects such as long development；Alimentary canal can also be damaged simultaneously, causes ulcer and bleeding；In addition, glucocorticoid is also to nerveous system
System has harmful effect, and inhibits immune response, not only infection is easily occurred, and infection is also covered after infection occurs
Symptom, cause the illusion of " peace reigns under heaven ".Meanwhile after removing long-term steroid, the after reaction of nervous centralis, it may appear that swash in vivo
Plain horizontal too low situation.Modern medical service guide is pointed out to use no or little such medicine as far as possible in principle, only caused in infection
Inflammatory reaction it is very serious so that threatening patient vitals in the case of, just heavy dose can use glucocorticoid in short term
Relief of symptoms.
Calcineurin inhibitors, including Tacrolimus paste and Elidel emulsifiable paste etc.：Such medicine is to T lymphs
The selective inhibitory action of cell, there is stronger antiinflammatory action, suitable for being in a bad way and the uppity patient of routine treatment.
But its prolonged application of discovered in recent years may occur in which the vascular lesion of liver, renal toxicity, neurotoxicity and transplanted kidney, close during medication
Monitoring blood pressure and renal function are cut, moreover, the state of an illness is easy repeatedly after being discontinued.
It anti-microbial agents (antibiotic), can be caused a kind of material during certain micro-organisms growth and breeding, use
In the antibiotic cured the disease in addition to thus directly extracting；Also manually synthesis or part are artificial synthesized completely.Antibiotics
It is more, including penicillins and cephalosporins, aminoglycoside, macrolides, echinocandin class, cyclosporin and Fourth Ring
Plain class etc..Antibiotic is used for the medicine for treating various Non-viral infections.But many secondary works are shown in Clinical practice
With the drug-fast problem of bacterial fungus is especially serious.For atopic dermatitis, because bacterium, fungi field planting or scabies secondary infection can
Induce or aggravate the state of an illness, antibiotic mainly especially has the control for oozing out the skin lesion state of an illness in heavier patient.
Other externally applied drugs such as zinc oxid oil (paste) agent, Pityrol ointment etc. also have certain curative effect effect to atopic dermatitis,
Physiological sodium chloride solution, 1%~3% boric acid solution and other Hydropathic compress medicaments have necessarily for oozing out for atopic dermatitis acute stage
Curative effect, Doxepin Hydrochloride Cream in Animals and part nonsteroidal anti-inflammatory drug have itching-relieving action.
Physical therapy includes phototherapy and ultraviolet therapy.These therapy effects are limited to, and ultraviolet therapy is not suitable for 6 years old
Infants Below.In March, 2009, European atopic dermatitis ad hoc working group and European skin disease and venereology can eczema working groups
The atopic dermatitis diagnosis of issue and treatment guidelines, the target for reaffirming treatment are only to keep the length of the atopic dermatitis patients state of an illness
Phase is well alleviated.Chinese 2014 editions suggestions of atopic dermatitis practice guidelines, patient should actively coordinate the treatment of doctor, and
" clothing, food, shelter, row, washing " each side pays attention to protecting, avoids contact with the factor for the exacerbation that induces an illness as far as possible, answer regular further consultation and length
Phase follow-up.In general, current doctor trained in Western medicine is only resided within mitigation and control plane, and many patients suffer from slight illness not for a long time
It must alleviate and the dual torment of poisonous side effect of medicine.
Atopic dermatitis and " infantile eczema " in the traditional Chinese medical science, " wet sore ", " acute eczema ", " wind of four fossae, atopic dermatitis " etc. are similar.Patient's sign
Complexity is showed, is that more cards are mutually simultaneous, and without single card type, most doctors think that atopic dermatitis and spleen, the heart, liver are in close relations, wet,
Wind, heat, the stasis of blood mainly show for it, and the insufficiency of the spleen with overabundance of dampness runs through the disease all the time.
In recent years, with Chinese medicine study further deeply, traditional Chinese medicine as a kind of potential effective treatment method, by
Gradually obtain international approval.1992~nineteen ninety-five, Sheehan et al. successively exists《Britain's skin disease magazine》Controlled etc. traditional Chinese medicine has been delivered
The controlled clinical trial of atopic dermatitis is treated, in terms of being shown in erythema and the improvement of dermatitis area, the advantage for the treatment of by Chinese herbs is notable, with
Visit 1 year only about half of patient to be benefited, there is nearly 20% patient to fully recover, without recurrence sign.The U.S., Japan, the idiocrasy skin of Britain
It is selectable method in reply atopic dermatitis diagnosis and treatment predicament that TCM Therapy is thought in scorching practice guidelines.European idiocrasy
Dermatitis ad hoc working group also begin to carry out system to the latent effect and security of Chinese medicine atopic dermatitis for 1991
Evaluation, it is believed that particularly obstinate atopic dermatitis patients intractable to part, the effect of it is short-term and at a specified future date are encouraging, are
The treatment method that can be selected.But it is small to be also free from side effects so far, it can effect a radical cure and control completely atopic dermatitis to recur
Active drug and treatment means.Therefore, the property of medicine feature of the beautiful fruit juice of Zong He Re of the present invention, stinkweed leaf and thyme leaf, is made
Medicine for external application.Noni fruit (NONI, scientific name Morinda Citrifolia) health-care efficacy is more, have " Morinda officinalis Genus queen " and
The title of " Thanks fruit ".Noni fruit tree is grown in South Pacific Ocean archipelago, Philippine, Hawaii, the torrid zone such as Hainan Island and Taiwan and
The excellent Noni fruit in subtropical countries and area, wherein high quality is clear essentially from South Pacific Ocean archipelago, there beautiful scenery, air
Newly, there are azure seawater, soft sandy beach and is green and luxuriant green, without industry, do not pollute.
Noni fruit is rich in 200 multiple nutritional components, including 13 kinds of vitamins (A, B, C, E etc.), 16 kinds of mineral matters (potassium, sodium,
Zinc, calcium, iron, magnesium, phosphorus, copper, selenium etc.), 8 kinds of rare elements, 20 several amino acids including 9 kinds of essential amino acids (are to plant
Containing the superpower combination that amino acid classes are most in thing), the material of the tool antioxidation of kind more than 10.Also contain a variety of alkaloids, more
The composition of the great medical values such as candy body, a variety of ferment.
Medical research shows, most strong antioxidant is currently known with three kinds, i.e., vitamin C, pure grape pip powder and
Green appearance is strong, compares, the antioxidation of Morinda Citrifolia juice is most strong.The antioxidation of Morinda Citrifolia juice is ascorbic 2.8 times, is
1.2 times of pure grape pip powder, it is green to hold strong 1.4 times.
Biological expert proposes, if three kinds of important holophytic nutrition element classification polysaccharides, antioxidant, alkaloids are simultaneously
Largely appear in a natural plants fruit, so that it may say it is revolutionary discovery.Nutritionist Sharp proposes, the battalion in Noni fruit
Form and point create the cooperative effect for having much power, that is, the effect of the power combined outclass single component.Hai Nikebo
Scholar has found that the compound celo contained by Noni fruit would rather rebuild repair cell tissue rapidly, exclude waste and toxin and activate sound
Cell tissue, cell metabolism, reparation and the overall process of regeneration activity are participated in, helps abnormal cell to recover normal function.
《American Pharmacopeia》Introduce that promise is beautiful an antibacterium, antiviral, antifungi, improve the functions such as immunity.
《The herbal antique catalog of China》In describe Nuo Li (NONI) various information in detail, promise beautiful (NONI) is referred to as in book
Morinda citrifolia L..Dried and be used as medicine with the root of morinda citrifolia L. in traditional Chinese medicine, referred to as Morinda.Its main performance is just dehumidifying
Zhuanggu, thus be frequently used to treat eczema and traumatic injury.The main component of Morinda and belong to rubiaceous Morinda officinalis phase together
It is similar, therefore the performance and can of Morinda is mentioned in the same breath with Morinda officinalis that is particularly important on Chinese herbal medicine and often applying.《Middle medical university
Dictionary》In explanation to Morinda officinalis it is rather detailed, it is Rubiaceae, is mainly distributed on the ground such as Guangdong, Hainan and Taiwan, and its root contains
There are vitamin C, mineral matter and polysaccharides, also contain and the composition such as Morinda identical war proclamation setting forth the purpose of the expedition and enumerating the crimes of the enemy tree.Morinda officinalis is commonly used for strengthening the bone,
Wind-damp dispelling, impotence and aconuresis, the uterus cold of insufficiency type are controlled, centering gas, treat oedema, control tinea pedis, enrich blood, preventing phlegm from forming and stopping coughing, controlling kidney deficiency waist
Pin is powerless, the diseases such as spleen paralysis, rheumatism bone disease, neurasthenia, insomnia, women's infertility of withering, and is improved immunologic function, promotes longevity
Effect.
Stinkweed, also known as smelly Chinese mugwort, herb fragrant the , Shi Yun perfume (or spice) section Zhi Wu Yun of common rue herb Huo Jing mustard seven.Stinkweed is perennial herb,
1 meter of Gao Ke Da, there are the strong Gas tastes of Strong.Base portion Mu Qualityization, full Zhu No hairs, You Xian Dot.Leaf alternates, 2~3 times plumage Like Complex Leaf, totally cleave to
5~15 centimetres of drastic crack , Long, the sliver Like of falling Luan Long Round shape, obovate or 1~2 centimetre of cochlear , Long, complete Edge or Wei You Blunt Tooth.Poly- Umbrella
Inflorescence Top lifes or axillary；Hua Golden yellows, 1~2 centimetre of Zhi Trail Approximately；Sepal 4~5, Fine is small, harbors；Petal 4~5, Side Edge Fine tears
Like；Stamen 8~10,4 Mei Stickers of Hua Chu Open Time With petals Right lifes lie prostrate 4 Mei More Long of , With sepals Right lifes Shang what petal, tiltedly out
Reveal , Sheng Open Time whole Xiong Rui And row Qie Deng Long together；Carpel 3~5, Shang Bu From lifes；Hua Disk You Xian Dot.The Room of capsule 4~5, it is ripe
Time Open split.Seed Kidney shapes, black.Spring at florescence.
Stinkweed Han Play Hair oil, Inner contain nonanone -2, undecyl ketone -2, nonyl alcohol -2, undecyl alcohol -2 and its Men acetic acid esters , An Leaf
Element, α-and nopinene, linalool, amphene , Zhang Brain alkene, Lemon lemon alkene, the poly- Umbrella florigen of Right etc..It Han Sheng Wu Jian：Yun Xiang Jian, vanilla wood
Ning Jian, Yin Yu Jian, 6- first epoxide Bai Fresh Jian , Jia Tin Mi Romania Guo Jian, mountain little Ju Jian, γ-Ya Jiao Jian , Yun Xiang Ning Jian , Yun perfume (or spice) acridines
Ketone, N- methyl slope La Tedesiming, day bar, Li Buddhist nun determined, and Yun perfume (or spice) Li Buddhist nun determines and its Men season ammonium From, 2- (4- (3,4- first dioxies
Base benzene) butyl) -4- Kui Snow ketone etc..Also Inner containing bergamot Zhi , Fill bone fat element, xanthotoxin, Umbrella shapes flower Inner Zhi , East henbane elements, Iso
The fragrant withered Ting , Yun perfume (or spice) of kiss-me Kao , Yun perfume (or spice) horse Reng , Yun throws away , Iso Europe celery Genus element second, Pan When Return elements etc..
The effect of stinkweed, is more, including Qu Wind, moves back Hot, diuresis, promoting blood circulation, removing toxic substances , Xiao Swollen；Zhi Gan Mao Hair Hot , Wind Wet ostalgia is small
Child Scared Wind, difficult urination , Guo Diarrhea, hernia Gas , Women Nv The Closed, Die Da Damage Injury, Hot poison Sore Ulcers, Wet rash etc..Soup Inner clothes (1~3 can be decocted
Money) , also Ke Pound Fu, Pound Zhi Tone are deposited or fill in the external applications such as nose.《Sward Drug Prepare will》Recording stinkweed can：" disappear Bai Du Swollen, dissipates big Sore,
Manage snake Injury "；《Southern Ning cities Drug Wu Chi》：" moving back Hot Qu Wind, diuresis Xiao Swollen, control little Child Hair Hot Scared Wind , Wind Wet ostalgia "；《Drug in Wide west
Will》：" control miasma Malaria, Hot poison Sore Ulcers and all Die and Da Damage Injury.External application centipede stings Injury "；《Middle Country Drug Zhi Fig. Kam》：" Zhi The Closed Bu Tone,
Colic "；《The western plant name Recording of Wide》：" Qu Wind detoxify, and Cool blood dissipates the stasis of blood.Zhi Gan Mao Hair Hot, moon The Bu Tone, bleeding from five sense organs or subcutaneous tissue, have a toothache , Boils Swollen, snake
Sting Injury ".《Fujian medium-height grass Drug》Record：Control small Child Wet rash-Fresh Chou Cao Stems , Leaf bis- Zhi San Money.Green Dou tri- Money.Open bubbles take.
In stinkweed contained Total Jian play the role of to release Ping Hua fully recover from an illness Twin.Contained furoeoumarin Class bergamot in stinkweed
Inner Zhi, Fill bone fat element, xanthotoxin etc. can cause outside the quick Right Pi Skin of Guang Over effect , Body, there is Kill Destroy Swollen knurl Fine born of the same parents'
Effect.Furoeoumarin Class Right Fine bacterium also have photosensitization：Ji Zhe Xie Wu Quality Cun Time, Ru Tong Time expose, and can cause Fine bacterium
It is dead.The outer Try Examination Zhong , Fill bone fat elements of Body, xanthotoxin (100 mcg/ml) Right Ren Xing Knot He Rod bacterium have inhibitory action, Umbrella
Shape spends Inner ester Right cloth LuShi Rod bacterium to have antibacterial action, and the Fill bone fat element such as ultraviolet Line of With, can some DNA virus of Destroy work and RNA with using
Virus.In addition, contained furoeoumarin in stinkweed, mountain little Ju Jian have anti-inflammatory Ji Kang Group Woven amine acts on.Iso bergenin Right rats
Real Examination Collapse Ulcers have moderate Bao Nursing effect.Yin Yu Jian Right muscle has paralysis effect, and lactation Move things can be caused by involving cardiac muscle
Xue Pressure Jin rows decline.
On the other hand, stinkweed has certain toxicity, stinkweed Suo Han Play Hair oil , You Difficult Wen Gas tastes and excitant, directly uses
Yu Pi Skin can cause bright Gan, Hair Red of Burn or even bubble；Dosage must be controlled when for oral administration；Meanwhile《The western Zhong Drug Chi of Wide》Indicate：It is " pregnant
Women avoids clothes ".
Thyme, also known as Mongollian Thyme Herb, Chinese prickly ash, Chinese pepper, lindera glauca, thyme etc., Shi mono- Seed Mining Select are from Thymus Pin Seed
Plant, there is the vanilla for cooking Ning and Drug Yong Price values, thyme originates in north African, Europe and Asia temperate zone.For in labiate hundred
Fragrant herb.Thyme stem is crawled shape, is taken root everywhere, multi-branched, bottom lignifying, rufous, high 3~15 lis on spray is straight
Rice, there is strong aroma gas.Leaf is to life；Tiny, oblong or avette, up to 15 millimeters, wide up to 7 millimeters, full edge is blunt nosed, base
Portion has bristle, there is short handle.Small, aubergine is spent, gathering branch end, forms wheel umbrella flower spike：Calyx green, calyx tube is bell, and tip 5 splits, larynx
Portion's hairiness；Corolla lip, lower lip 3 split；Stamen 4, the last 2；Gynoecium 1.Pyrene ellipse, positioned at the bottom of place calyx.Thyme is given birth to
With being longer than dry hillside chiltern, the ground such as the Inner Mongol, Gansu, Shaanxi, northeast are distributed mainly in China.6~July harvests, and dries in the shade
Or using fresh herb
Thyme contains volatile oil, to spend flower content best.Its main component be Thymol (Thymol), baicalein,
The flavone components such as glucoside, luteolin-7-glucoside, apiolin, carvacrol (Carvacrol), linalool
(Linalool) multiple compounds such as cymol (p-Cymol).There is the effect such as antibechic, anti-inflammatory, anti-corrosion.Excess has stronger
Excitant, liver can be denatured.
Thyme has the smell of fragrance, very early when just appear in people as a kind of flavored vegetable, nectariferous plant
Life in, be one of natural flavoring that the mankind apply from ancient times to the present.China adjusts early in the Yuan Dynasty with regard to useful thyme
The record of savory material, the Yuan Dynasty《Must act Class complete or collected works at home》In, remember that useful thyme adds the Camel hoof seasoning of Camel peaks.Li Shizhen (1518-1593 A.D.)
《Compendium of Materia Medica》Record：' taste micro-pungent, natives are eaten with boiling mutton, fragrant U.S. thyme '.Cooking the food such as seafood, meat, fish
When, a little thyme powder can be added, except smelling removal, to increase the flavor of dish；Thyme is added when salted vegetables and pickles, can be improved
Their delicate fragrance and hay-scented taste year, thymic natural anticorrosion effect also become the green of meat pulp, sausage, daube and pickles
Harmless perfume additive.Abroad, the cheese and wine that Roman makes all make flavoring with it, and thyme or French food must
Standby spices.1970, International Organization for standardization (International Standard Organization) announced thyme
It may be used as food spice.
Thyme can treat a variety of diseases, smell sweet tea and like medicinal herbs taste.Thyme can trace in the medicinal record of China
To the Northern Song Dynasty.The various classics of TCM have described.《Shaanxi Chinese herbal medicine》Have recorded it can control indigestion, have aches and pains all over, wind-dispelling
Analgesia, small distention and fullness in the abdomen, have a toothache, control stomach cold pain；《It is good to help book on Chinese herbal medicine》Call its main fried swelling and pain of leaching；《Chinese Herbal Medicine in Xinjiang handbook》It has recorded and control
Flu, wind-dispelling, reinforcing spleen to promote digestion, the effect of relieving cough and reducing sputum, warming spleen and stomach for dispelling cold,《The sweet peaceful blue or green Chinese herbal medicine choosing in Shan》It has recorded stomach preventing or arresting vomiting and clear heat
It is antipyretic；《Middle traditional Chinese medicines plant illustrated handbook》Recording it has antispastic, wind dispelling, strong effect, cures mainly inflammation, spasmodic cough, pertussis, larynx
Head swelling and pain.It is modern it is medicinal be fresh sample or the sample that dries in the shade with its aerial part or herb, have wind-dispelling, the function of analgesic.
20 to the 54% thymol composition that thyme essential oil contains, have fungi-proofing function and by Yong Yu Tone with mouthwash,
Anti- grey first fungi Drug and anti-cough or branch Gas pipe inflammation Drug, many Elixirs that sterilize also contain thymol.Before Now are for antibiotic Yan Hair,
Thyme essential oil Hui by Yong Yu System Zuo Tu Drug Stretch Tapes, have Kill bacterium, Slow Xie Spasm , eliminating the phlegm Elixirs and Town be set for using.Chew food She Xiang Cao The
Can be with the flat feelings Xu of Ask.Thyme decoction or liquid extract can be as bronchitis or the protective agents and neuritis of other respiratory tract diseases
Or the anodyne of radiculitis.
The content of the invention
The present invention provides a kind of atopic dermatitis Chinese medicine preparation, preparation method and its usage, and it is the skins such as atopic dermatitis
Effective treatment traditional Chinese medicine of skin disease chronic disease, it uses the property of medicine feature of the beautiful fruit juice of Re, stinkweed leaf and thyme leaf, manufactured outer
The skin disease chronic diseases such as the atopic dermatitis of asthma initiation are effectively treated in the topical application of drug.
In order to complete present invention purpose, the present invention uses following technical scheme：
A kind of atopic dermatitis Chinese medicine preparation of the present invention, wherein：It includes：The Morinda Citrifolia juice calculated according to volume ferments
0.5 part of 10 parts of Normal juice, 1 part of stinkweed leaf juice and thyme leaf juice, Morinda Citrifolia juice fermentation Normal juice is that the Noni fruit of fresh mature is clear
Wash and dry, placed 3 months in the closed container at a temperature of 25 DEG C~35 DEG C, make its spontaneous fermentation, filter and Noni fruit hair is made
Ferment Normal juice；
A kind of atopic dermatitis Chinese medicine preparation of the present invention, wherein：The beautiful fruits of Suo Shu Re include：From being grown on the South Pacific Ocean
Archipelago, Philippine, Hawaii, Hainan Island, Taiwan, the torrid zone or semi-tropical Noni fruit；
A kind of atopic dermatitis Chinese medicine preparation of the present invention, wherein：The stinkweed leaf originate from China or all over the world
Stinkweed leaf；The thyme leaf is to originate from China or thyme leaf all over the world；
A kind of preparation method of atopic dermatitis Chinese medicine preparation of the present invention, it comprises the following steps：By fresh mature
Noni fruit cleaning is dried, and is placed 3 months in the closed container at a temperature of 25 DEG C~35 DEG C, makes its spontaneous fermentation, and filtering is made
Noni fruit fermentation Normal juice；Fresh the stinkweed leaf and thyme leaf chosen are cleaned with clear water, sterilized, squeezed the juice and are filtrated to get respectively
Stinkweed leaf juice and thyme leaf juice；By the volume ratio of formula, respectively by Morinda Citrifolia juice ferment 10 parts of Normal juice, 1 part of stinkweed leaf juice and
0.5 part of thyme leaf juice uniformly after mixing, obtains atopic dermatitis Chinese medicine preparation；
A kind of purposes of atopic dermatitis Chinese medicine preparation of the present invention, wherein：The atopic dermatitis Chinese medicine preparation is to use
In the medicine for the treatment of atopic dermatitis；
A kind of purposes of atopic dermatitis Chinese medicine preparation of the present invention, wherein：The atopic dermatitis Chinese medicine preparation is being controlled
Treat in the medicine of atopic dermatitis and account for 10-90%, remaining is auxiliary material；
A kind of purposes of atopic dermatitis Chinese medicine preparation of the present invention, wherein：Described auxiliary material is starch, sorbierite, wheat
Bud sugar, glucose, sucrose, lactose, silicon derivative, cellulose and its derivates, gelatin, glycerine, talcum powder, calcium carbonate, carbonic acid
One or more of mixtures in hydrogen calcium, distilled water, cyclodextrin；
A kind of purposes of atopic dermatitis Chinese medicine preparation of the present invention, wherein：It is described treatment atopic dermatitis medicine be
Suppository, soft or hard paste, creme, spray, drops, patch, tablet, sugar coated tablet, enteric coated tablet, capsule, hard capsule,
Soft capsule, oral liquid, mouth containing agent, granule, electuary, pill, powder, sublimed preparation, pulvis or injection.
The property of medicine feature of the beautiful fruit juice of atopic dermatitis Chinese medicine preparation Zong He Re of the present invention, stinkweed leaf and thyme leaf,
Invigorating the spleen, raising immunologic function, Hang Gas Seepage Wet, Qu Wind, promoting blood circulation, Town are determined into, Xiao Swollen removing toxic substances, sterilization, antibacterium, antiviral, anti-mildew
The property of medicine such as bacterium, toxin expelling, cell tissue reparation activation and its regeneration function are merged, and are not only taken stopgap measures but also are consolidated, manufactured external application
Medicine can effectively treat the skin disease chronic diseases such as the atopic dermatitis of asthma initiation.
Embodiment
The atopic dermatitis Chinese medicine preparation of the present invention includes：Morinda Citrifolia juice fermentation 10 parts of the Normal juice, smelly calculated according to volume
0.5 part of 1 part of blade of grass juice and thyme leaf juice, Morinda Citrifolia juice fermentation Normal juice is to dry the Noni fruit cleaning of fresh mature, 25
DEG C~35 DEG C at a temperature of closed container in place 3 months, make its spontaneous fermentation, filter that Noni fruit proferment Zhi , Re are made is beautiful
Fruit includes：From being grown on South Pacific Ocean archipelago, Philippine, Hawaii, Hainan Island, Taiwan, the torrid zone or semi-tropical Noni fruit,
Stinkweed leaf is to originate from China or stinkweed leaf all over the world；Thyme leaf is to originate from China or thyme leaf all over the world.
The preparation method of the atopic dermatitis Chinese medicine preparation of the present invention, it comprises the following steps：By the Nuo Li of fresh mature
Fruit cleaning is dried, and is placed 3 months in the closed container at a temperature of 25 DEG C~35 DEG C, makes its spontaneous fermentation, and it is beautiful to filter obtained promise
Fruit fermentation Normal juice；Stinkweed is cleaned, sterilized, squeezed the juice and are filtrated to get respectively to fresh the stinkweed leaf and thyme leaf chosen with clear water
Leaf juice and thyme leaf juice；By the volume ratio of formula, Morinda Citrifolia juice is fermented in 10 parts of Normal juice, 1 part of stinkweed leaf juice and hundred respectively
0.5 part of spiceleaf juice uniformly after mixing, obtains atopic dermatitis Chinese medicine preparation.
Atopic dermatitis Chinese medicine preparation of the present invention is the medicine for treating atopic dermatitis, the atopic dermatitis Chinese medicine
Preparation accounts for 10-90% in the medicine for the treatment of atopic dermatitis, and remaining is auxiliary material, and auxiliary material is pharmaceutically acceptable carrier, such as
Starch, sorbierite, maltose, glucose, sucrose, lactose, silicon derivative, cellulose and its derivates, gelatin, glycerine, talcum
Powder, calcium carbonate, calcium bicarbonate, distilled water, one or more of mixtures of cyclodextrin, the medicine for treating atopic dermatitis are bolt
It is agent, soft or hard paste, creme, spray, drops, patch, tablet, sugar coated tablet, enteric coated tablet, capsule, hard capsule, soft
Capsule, oral liquid, mouth containing agent, granule, electuary, pill, powder, sublimed preparation, pulvis or injection.
Treat the when effect of the medicine of atopic dermatitis：
There is slight respiratory tract asthma since 1 years old in patient, started within 1 years old half the atopic dermatitis for skin asthma occur, hair
Be born in the fossa cubitalis, popliteal nest and shank and stretch side, extend to wrist and both hands the back of the hand at nearly 10 years old, the following dermatitis coverage rate of wrist up to~
60%, fash dries plumpness at periphery, there is obvious lichenification, and centre is seriously oozed out.
Patient did anaphylactogen test for several times between several years, and parent takes the safeguard procedures such as moisturizing and isolation anaphylactogen always,
Period tosses about Duo Jia medical institutions, treat the Western medicine of atopic dermatitis almost with time, all how rare certain effect during treatment every time,
But in several weeks, no longer than 3 months, dermatitis recurred again.When patient is nearly 10 years old, dermatitis extends to wrist and both hands the back of the hand, hand
The following dermatitis coverage rate of wrist reaches~60%, and fash dries plumpness at periphery, there is obvious lichenification, and centre is seriously oozed out, and uses
Original western medicine, almost without effect.Patient dare not go out, and can not participate in the multinomial work such as swimming and the technique class of school
It is dynamic.
External application for curing is newly formulated using of the invention, totally 5 courses for the treatment of, each course for the treatment of 7 days.After first course for the treatment of, dermatitis covering
The expansion in face is curbed, and oozes out mitigation, and lichenification relaxes；After second course for the treatment of, do not ooze out substantially, lichenification enters one
Step relaxes, and dries plump peripheral skin and starts shedding off；After 3rd course for the treatment of, complete stopping is oozed out, is covered for new skin, liver moss
Sample becomes basic and disappeared, and plump peripheral skin further comes off；After 4th course for the treatment of, new skin growth is complete, and lichenification disappears
Lose, coming off for plump peripheral skin is basically completed, and the symptom of atopic dermatitis disappears；It is consolidation and maintenance after 5th course for the treatment of
Process, after the course for the treatment of, the symptom of patient's atopic dermatitis is wholly absent, full recovery normal skin shape at original dermatitis.This
8 months so far after the new formula external application for curing of invention, normal skin shape is always maintained at the original dermatitis of patient, without any recurrence
Sign.
Industrial applicibility
Atopic dermatitis Chinese medicine preparation, the preparation method and its usage of the present invention can in the industry be manufactured, and had
The effect of atopic dermatitis.
Above description is explanation of the invention, is not the restriction to invention, limited range of the present invention is referring to right
It is required that in the case of the spirit without prejudice to the present invention, the present invention can make any type of modification.
Claims (8)
- A kind of 1. atopic dermatitis Chinese medicine preparation, it is characterised in that：It includes：The Morinda Citrifolia juice fermentation Normal juice calculated according to volume 0.5 part of 10 parts, 1 part of stinkweed leaf juice and thyme leaf juice, Morinda Citrifolia juice fermentation Normal juice are that the Noni fruit cleaning of fresh mature is dried in the air It is dry, placed 3 months in the closed container at a temperature of 25 DEG C~35 DEG C, make its spontaneous fermentation, filtered and Noni fruit proferment is made Juice.
- 2. atopic dermatitis Chinese medicine preparation according to claim 1, it is characterised in that：The beautiful fruits of Suo Shu Re include：Come spontaneous It is longer than South Pacific Ocean archipelago, Philippine, Hawaii, Hainan Island, Taiwan, the torrid zone or semi-tropical Noni fruit.
- 3. atopic dermatitis Chinese medicine preparation according to claim 1 or 2, it is characterised in that：The stinkweed leaf is in originating from State or stinkweed leaf all over the world；The thyme leaf is to originate from China or thyme leaf all over the world.
- 4. a kind of preparation method for manufacturing atopic dermatitis Chinese medicine preparation as claimed in claim 1, it comprises the following steps：Will be new Fresh ripe Noni fruit cleaning is dried, and is placed 3 months in the closed container at a temperature of 25 DEG C~35 DEG C, is made its spontaneous fermentation, Noni fruit fermentation Normal juice is made in filtering；Fresh the stinkweed leaf and thyme leaf chosen are cleaned with clear water respectively, sterilized, is squeezed the juice and It is filtrated to get stinkweed leaf juice and thyme leaf juice；By the volume ratio of formula, respectively by 10 parts of Normal juice of Morinda Citrifolia juice fermentation, stinkweed leaf After 0.5 part of 1 part of juice and thyme leaf juice uniformly mix, atopic dermatitis Chinese medicine preparation is obtained.
- A kind of 5. purposes of atopic dermatitis Chinese medicine preparation as claimed in claim 1, it is characterised in that：The atopic dermatitis Chinese medicine preparation is the medicine for treating atopic dermatitis.
- A kind of 6. purposes of atopic dermatitis Chinese medicine preparation as claimed in claim 5, it is characterised in that：The atopic dermatitis Chinese medicine preparation accounts for 10-90% in the medicine for the treatment of atopic dermatitis, and remaining is auxiliary material.
- A kind of 7. purposes of atopic dermatitis Chinese medicine preparation as claimed in claim 6, it is characterised in that：Described auxiliary material is shallow lake Powder, sorbierite, maltose, glucose, sucrose, lactose, silicon derivative, cellulose and its derivates, gelatin, glycerine, talcum powder, One or more of mixtures in calcium carbonate, calcium bicarbonate, distilled water, cyclodextrin.
- A kind of 8. purposes of atopic dermatitis Chinese medicine preparation as claimed in claim 7, it is characterised in that：The treatment idiocrasy The medicine of dermatitis is suppository, soft or hard paste, creme, spray, drops, patch, tablet, sugar coated tablet, enteric coated tablet, capsule Agent, hard capsule, soft capsule, oral liquid, mouth containing agent, granule, electuary, pill, powder, sublimed preparation, pulvis or injection.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2016/096343 WO2018035706A1 (en) | 2016-08-23 | 2016-08-23 | Traditional chinese medicine preparation for atopic dermatitis, preparation method therefor and use thereof |
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| CN107635573A true CN107635573A (en) | 2018-01-26 |
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| WO (1) | WO2018035706A1 (en) |
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| CN112569282B (en) * | 2020-12-28 | 2022-01-04 | 仲恺农业工程学院 | Bacteriostatic composition containing morinda citrifolia extract and abelmoschus manihot extract |
| CN112870330A (en) * | 2021-01-27 | 2021-06-01 | 贝壳派创新科技（深圳）有限公司 | Wet plaster for treating acute exudative dermatitis and eczema and preparation method thereof |
| CN116616340B (en) * | 2023-04-19 | 2024-03-12 | 广东省科学院生物与医学工程研究所 | Method for preserving bananas based on noni fermentation residue fermentation liquor as preservative |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101489396A (en) * | 2006-05-12 | 2009-07-22 | 大溪地诺丽国际公司 | Method and composition for administering bioactive compounds derived from morinda citrifolia |
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| CN101313767B (en) * | 2008-06-25 | 2011-09-28 | 西南林学院 | Compound fruit juice of Nori normal juice and Passiflora coeurlea normal juice, and preparation method thereof |
| CN104524118A (en) * | 2014-12-03 | 2015-04-22 | 天峨县平昌生态农业有限公司 | Itching-relieving soothing cream and preparation method thereof |
| CN105250760A (en) * | 2015-10-15 | 2016-01-20 | 高艳丽 | Traditional Chinese medicine external lotion for treating infant eczema |
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2016
- 2016-08-23 WO PCT/CN2016/096343 patent/WO2018035706A1/en active Application Filing
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101489396A (en) * | 2006-05-12 | 2009-07-22 | 大溪地诺丽国际公司 | Method and composition for administering bioactive compounds derived from morinda citrifolia |
Non-Patent Citations (3)
| Title |
|---|
| 于纯淼等: "诺丽发酵果汁润肠通便作用效果观察", 《辽宁中医药大学学报》 * |
| 杜琳: "《花养女人幸福一生大全集》", 31 January 2012 * |
| 梁光裕: "诺丽果汁的量子医学最新研究报告", 《知识经济》 * |
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