CN114259517B - Traditional Chinese medicine aromatherapy gel for treating allergic rhinitis - Google Patents
Traditional Chinese medicine aromatherapy gel for treating allergic rhinitis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine aromatherapy gel for treating allergic rhinitis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 6-12 parts of divaricate saposhnikovia root, 7-15 parts of dahurian angelica root, 5-15 parts of biond magnolia flower, 2-8 parts of cocklebur fruit, 10-18 parts of mint, 12-17 parts of chrysanthemum, 8-14 parts of belvedere fruit and 4-13 parts of dark plum fruit. The traditional Chinese medicine aromatherapy gel is prepared from the traditional Chinese medicine aromatherapy gel, has obvious effects of improving symptoms of allergic rhinitis, such as nasal obstruction, watery nasal discharge, eye and nose pruritus and the like, and has the advantages of high symptom improving speed, short period, low recurrence rate and good market prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine aromatherapy gel for improving clinical symptoms of allergic rhinitis.
Background
Allergic Rhinitis (AR) is one of the most common diseases in the otorhinolaryngological department, and is mainly characterized by sudden and repeated episodes of nasal itching, sneezing, watery nasal discharge, nasal obstruction, and the like. The incidence rate is in a remarkable rising trend in recent years. Epidemiological investigation shows that allergic rhinitis is not a completely isolated disease, and is often combined with bronchial asthma, allergic conjunctivitis, nasosinusitis, nasal polyp and the like, so that sufficient attention should be paid to the clinical application.
At present, most of research on allergic rhinitis focuses on the treatment aspect, western medicine treatment of allergic rhinitis mainly comprises immunotherapy and drug therapy, the immunotherapy has a long treatment course and is not easy to adhere to, and the symptoms can be temporarily relieved by using anti-allergy and hormone drugs, but the side effects are easy to appear or are light or heavy; although the drug treatment can improve symptoms quickly, the symptoms are easy to relapse and have large toxic and side effects. The traditional Chinese medicine treatment is mainly oral administration, external application and acupuncture, and the oral administration and the acupuncture bring certain pain to patients, have long treatment course and are not easy to accept by the patients; the topical medicine is mainly directly applied in nasal cavity, and can cause irreversible damage to nasal mucosa when improperly applied.
Disclosure of Invention
In view of the above, the invention provides the traditional Chinese medicine aromatherapy gel for treating the allergic rhinitis, which is simple to use, free of pain, quick in effect, good in curative effect and low in adverse drug reaction, and overcomes the defects of the existing clinical medicines.
In order to achieve the purpose, the invention provides the following technical scheme:
the first technical scheme is as follows: a traditional Chinese medicine composition for treating allergic rhinitis comprises the following raw materials in parts by mass: 6-12 parts of divaricate saposhnikovia root, 7-15 parts of dahurian angelica root, 5-15 parts of biond magnolia flower, 2-8 parts of cocklebur fruit, 10-18 parts of mint, 12-17 parts of chrysanthemum, 8-14 parts of belvedere fruit and 4-13 parts of dark plum fruit.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by mass: 9 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 9 parts of biond magnolia flower, 5 parts of cocklebur fruit, 15 parts of mint, 15 parts of chrysanthemum, 9 parts of belvedere fruit and 9 parts of dark plum fruit.
The second technical scheme is as follows: a preparation method of a traditional Chinese medicine composition comprises the following steps:
weighing raw materials by weight, cleaning, pulverizing to 80-100 mesh, mixing, and supercritical CO 2 Extracting volatile oil by extraction process to obtain orange yellow crude oil, i.e. the traditional Chinese medicine composition.
Preferably, the pressure in the extraction process is 35-40MPa, the temperature is 40-50 ℃, and the flow is 40kg/h.
The third technical scheme is as follows: a Chinese medicinal aromatherapy gel is prepared from Chinese medicinal composition.
The technical scheme is as follows: a preparation method of traditional Chinese medicine aromatherapy gel comprises the following steps:
adding water into carrageenan, standing for 24h, adding the traditional Chinese medicine composition and an activating agent, heating the obtained mixture to boil, cooling to 70 ℃, adding triethanolamine and potassium sorbate, stirring, cooling and solidifying to obtain the traditional Chinese medicine aromatherapy gel.
Adding water into carrageenan, standing to fully swell the carrageenan to obtain the gel matrix. The role of triethanolamine is to adjust the pH to 6.9.
Preferably, the mass ratio of the traditional Chinese medicine composition to the carrageenan to the active agent is 1: (0.1-0.3): (0.08-0.1).
Preferably, the active agent is laurocapram.
Preferably, the adding amount of the triethanolamine is 0.2-0.4% of the mass of the mixture, and the adding amount of the potassium sorbate is 0.1-0.3% of the mass of the mixture.
The water content of the obtained Chinese medicinal aromatherapy gel is 40%.
Wind prevention: pungent and sweet in flavor and warm in nature. Enter bladder, lung, liver and spleen meridians. Has effects of relieving exterior syndrome, dispelling pathogenic wind, eliminating dampness, relieving pain, and relieving spasm. It can be used for treating wind-cold type common cold, headache, blurred vision, neck stiffness, arthralgia due to wind-cold-dampness, joint pain, spasm and spasm of limbs, and tetanus. The main components of modern research are volatile oils such as 2-methyl-3-buten-2-ol, valeraldehyde, alpha-pinene, hexanal, pentanol, hexanol, octanal, octanol, coumarin psoralen, acetophenone, 7-octen-4-ol, naphthalene, polyacetylene, beta-bisabolene, thujaplicin, beta-eucalyptol, beta-sitosterol, bergapten and phellandrin. Has antipyretic, analgesic, tranquilizing, antibacterial, antiinflammatory, and immunity enhancing effects.
Radix angelicae: the angelica dahurica has aromatic smell, pungent and fragrant flavor and can disperse and warm to dispel cold, and has the effects of dispelling wind cold, dredging orifices, relieving pain, eliminating dampness, stopping leukorrhagia, reducing swelling, eliminating dense, treating exterior syndrome with dampness, headache and nasal obstruction, yangming headache, glabellar bone pain, nasosinusitis headache, toothache, anemofrigid-damp arthralgia, cold-damp leukorrhagia, sore and carbuncle swelling and toxin.
And (3) magnolia flower: property and taste: pungent and warm; meridian tropism: entering lung and stomach meridians; the functional indications are as follows: dispelling wind and cold, and dredging nasal orifice; can be used for treating wind-cold headache, nasal obstruction, nasosinusitis, and thick nasal discharge; xinyi is good at treating nasal obstruction, nasosinusitis, lung qi, nasal orifices, nasal discharge, clear nasal discharge, nasal obstruction, headache, nasal discharge and fishy smell. Has inhibitory effect on 10 pathogenic fungi such as trichophyton interdigital. The main ingredient comprises volatile oil such as citral, eugenol, 1, 8-cineole, terpinen-4-ol, bornyl acetate, 1, 8-cineole, camphor, beta-pinene, 1, 8-cineole, etc. Lignan components such as alkaloids, terpineol dimethyl ether, liriodendron resin dimethyl ether, governin and zeylangenin. Has the functions of resisting compression, resisting bacteria, exciting and smoothing.
Fructus xanthil: is fruit of Xanthium strumarium with involucre of Compositae. Sweet in flavor, warm in nature and toxic. Enter lung and liver meridians. Has effects of dispelling pathogenic wind, relieving pain, eliminating dampness, and killing parasite. The main components comprise xanthiin, xanthinol, isoxanthinol, xanthylic ester and fatty oil, wherein the oil contains a large amount of linoleic acid, oleic acid, palmitic acid and stearic acid. In addition, it contains protein, alkaloid, vitamin C, pigment, etc. Has antibacterial, antitussive, blood sugar lowering, blood pressure lowering, and respiratory exciting effects.
Mint: property and taste: pungent taste and cool nature; meridian tropism: entering lung and liver meridians; the functional indications are as follows: disperse wind-heat, clear head and eyes, relieve sore throat, promote eruption and relieve depression. It is mainly indicated for exterior syndrome due to wind-heat, headache, conjunctival congestion, swollen and sore throat, measles without adequate eruption, itching, liver depression and hypochondriac pain. The main component of the mint volatile oil is menthol which belongs to terpene penetration enhancer, and the main action mechanism of the menthol volatile oil is to destroy the lipid barrier of cells in the horny layer, increase the distribution of the drug from a water-soluble matrix to the horny layer and cause the change of the ultrastructure when the menthol volatile oil acts on the epidermis of the skin; menthol can be preferentially distributed into the stratum corneum of intercellular space and then reversibly divides intercellular lipid, so that the permeation of the medicament is increased, meanwhile, the fluidity of lipid bilayers is increased, the permeability of the medicament is improved, and the menthol has the strongest effect in traditional Chinese medicine permeation enhancers.
Chrysanthemum: bitter and sweet in taste, slightly cold in nature; dispelling pathogenic wind and clearing heat, calming liver and improving eyesight, and clearing away heat and toxic materials; can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling. It can disperse wind-heat, calm down liver yang, clear liver and improve vision, and can be used to treat wind-heat type common cold or warm disease, fever, slight aversion to wind-cold, headache, liver yang hyperactivity, headache and vertigo, conjunctival congestion and swelling pain caused by wind-heat attack or liver fire flaming up, and syndromes such as liver and kidney essence and blood deficiency, dim and dim eyesight, etc., and has strong effects of calming liver, clearing liver and improving vision.
The preparation method comprises the following steps of (1) preparing broom cypress fruit: pungent, bitter and cold in nature; entering kidney and bladder meridians; clear heat, promote diuresis, dispel wind and relieve itching. Can be used for treating difficult and painful urination, pruritus vulvae, leukorrhagia, rubella, eczema, and skin pruritus.
Dark plum: is an immature fruit of Prunus mume (Thunb.) Sieb of Rosaceae. Sour, astringent and neutral. It enters liver, spleen, lung and large intestine meridians. Has effects in astringing lung, relieving cough, relieving diarrhea with astringents, promoting fluid production, quenching thirst, and calming ascaris. The mume fructus contains citric acid, malic acid, succinic acid, carbohydrate, sitosterol, wax-like substance and oleanolic acid-like substance. Has strong bactericidal property, and can improve liver function, contains picric acid, and can relieve pain due to heat, and pulp contains superoxide dismutase with high activity. It is clinically used for treating lung deficiency, chronic cough, chronic dysentery, intestine dryness, asthenia heat, thirst, colic, vomiting and abdominal pain; biliary ascariasis.
Compared with the prior art, the invention has the following beneficial effects:
the invention strictly controls the dosage of each raw material, controls the dosage proportion and adopts supercritical CO 2 The volatile oil is extracted by the extraction process, so that the extraction rate of the obtained volatile oil is improved, the content of active ingredients is increased, and a better treatment effect can be exerted.
The traditional Chinese medicine aromatherapy gel prepared by the invention has a remarkable effect on improving the clinical symptoms of allergic rhinitis, and the aromatherapy dosage form enables essential oil components to directly enter the nasal cavity and quickly reach other parts of a human body, so that the symptoms of rhinitis can be quickly improved and relieved, the permeability of the nasal cavity is enhanced, and the allergic symptoms are improved. Meanwhile, the aromatherapy preparation can also improve the mood, avoid the fear and side effects of medication, especially for patients who cannot accept oral drugs and have large side effects after oral administration, can be used at will without too many contraindications, and plays a role that internal treatment can not play. The method has the advantages of high symptom changing speed, short period, low recurrence rate and good market prospect.
Detailed Description
Reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Further, for numerical ranges in this disclosure, it is understood that each intervening value, between the upper and lower limit of that range, is also specifically disclosed. Every smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference herein for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the present disclosure without departing from the scope or spirit of the disclosure. Other embodiments will be apparent to those skilled in the art from consideration of the specification. The specification and examples are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are open-ended terms that mean including, but not limited to.
The "parts" described in the following examples are all "parts by mass".
Example 1
A traditional Chinese medicine composition for treating allergic rhinitis comprises the following raw materials in parts by mass:
9 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 9 parts of biond magnolia flower, 5 parts of cocklebur fruit, 15 parts of mint, 15 parts of chrysanthemum, 9 parts of belvedere fruit and 9 parts of dark plum fruit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the mass parts, cleaning, respectively crushing the raw materials to the particle size of 100 meshes, mixing the powder, and then adopting supercritical CO 2 Extracting volatile oil by extraction process at 45 deg.C under 38MPa and 40kg/hWithin 3h, obtaining orange yellow crude oil, namely the traditional Chinese medicine composition.
The preparation method of the traditional Chinese medicine aromatherapy gel comprises the following steps:
adding water into carrageenan, standing for 24h, adding the traditional Chinese medicine composition and laurocapram, heating the obtained mixture to boiling, cooling to 70 ℃, adding triethanolamine accounting for 0.3% of the mixture and potassium sorbate accounting for 0.2% of the mixture, stirring, cooling and solidifying to obtain the traditional Chinese medicine aromatherapy gel. Wherein the mass ratio of the traditional Chinese medicine composition to the carrageenan to the laurocapram is 1:0.2:0.09.
example 2
A traditional Chinese medicine composition for treating allergic rhinitis comprises the following raw materials in parts by mass: 6 parts of divaricate saposhnikovia root, 15 parts of dahurian angelica root, 8 parts of biond magnolia flower, 3 parts of siberian cocklour fruit, 10 parts of mint, 12 parts of chrysanthemum, 14 parts of belvedere fruit and 5 parts of dark plum fruit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the mass parts, cleaning, respectively crushing the raw materials to 80 meshes, mixing the powder, and then adopting supercritical CO 2 Extracting volatile oil by extraction process, wherein the pressure is 40MPa, the temperature is 40 ℃, the flow is 40kg/h, and the time is 3h, and obtaining orange yellow crude oil, namely the traditional Chinese medicine composition.
The preparation method of the traditional Chinese medicine aromatherapy gel comprises the following steps:
adding water into carrageenan, standing for 24h, adding the traditional Chinese medicine composition and laurocapram, heating the obtained mixture to boiling, cooling to 70 ℃, adding triethanolamine accounting for 0.4% of the mixture and potassium sorbate accounting for 0.1% of the mixture, stirring, cooling and solidifying to obtain the traditional Chinese medicine aromatherapy gel. Wherein the mass ratio of the traditional Chinese medicine composition to the carrageenan to the laurocapram is 1:0.3:0.1.
example 3
A traditional Chinese medicine composition for treating allergic rhinitis comprises the following raw materials in parts by mass: 15 parts of divaricate saposhnikovia root, 7 parts of dahurian angelica root, 15 parts of biond magnolia flower, 6 parts of siberian cocklour fruit, 14 parts of mint, 16 parts of chrysanthemum, 10 parts of belvedere fruit and 10 parts of dark plum fruit.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the raw materials according to the mass parts, cleaning, respectively crushing the raw materials to 80 meshes, mixing the powder, and then adopting supercritical CO 2 Extracting volatile oil by extraction process, wherein the pressure is 35MPa, the temperature is 50 ℃, the flow is 40kg/h, and the time is 3h, and obtaining orange yellow crude oil, namely the traditional Chinese medicine composition.
The preparation method of the traditional Chinese medicine aromatherapy gel comprises the following steps:
adding water into carrageenan, standing for 24h, adding the traditional Chinese medicine composition and laurocapram, heating the obtained mixture to boiling, cooling to 70 ℃, adding triethanolamine accounting for 0.2% of the mixture and potassium sorbate accounting for 0.3% of the mixture, stirring, cooling and solidifying to obtain the traditional Chinese medicine aromatherapy gel. Wherein the mass ratio of the traditional Chinese medicine composition to the carrageenan to the laurocapram is 1:0.2:0.08.
1. acute toxicity test
The toxic reaction generated by the short-term contact of the intact skin and the damaged skin of the rabbit with the traditional Chinese medicine aromatherapy gel prepared in the embodiment 1 of the invention is observed.
Rabbits were divided into blank and experimental groups, which were divided into intact skin groups: removing hair from both sides of spinal column of rabbit 24 hr before administration, and removing hair area of about 15 × 10cm 2 (ii) a Group of damaged skin: removing hair from both sides of spinal column of rabbit 24 hr before administration, and removing hair area of about 15 × 10cm 2 And after 24h of hair removal, the skin is disinfected and scratched by a needle to stab the epidermis, not damage the dermis and slightly ooze blood. The blank set was not processed. Each group comprises 10 male and female halves. Adding 0.1g of traditional Chinese medicine aromatherapy gel into 1L of water to perform aromatic fumigation on the depilated area of the back of the animal, covering the fumigated area with gauze after 5min of fumigation, fixing the fumigated area with adhesive plaster, washing off the tested medicine after 24h of test, and continuously observing for 7 days, wherein no toxic reaction is found.
2. Clinical observations
400 patients with allergic rhinitis were selected for experimental observation of the drug of the present invention. Among 400 patients, factors such as the severity of rhinitis symptoms, the age and sex of the patients are not considered, the 400 patients are divided into 4 groups, 1-3 groups are fumigated by the traditional Chinese medicine aromatherapy gel prepared in examples 1-3, the 4 th group is taken as a control group for oral administration, the treatment period is 7 days, and the results are shown in table 1.
The preparation method of the oral decoction of the control group comprises the following steps:
the product comprises the following raw materials in parts by mass: 15 parts of astragalus membranaceus, 12 parts of cocklebur fruits, 12 parts of bighead atractylodes rhizome, 3 parts of asarum, 9 parts of platycodon grandiflorum, 9 parts of divaricate saposhnikovia roots, 9 parts of radix angelicae, 6 parts of mint, 9 parts of rhizoma acori graminei, 9 parts of biond magnolia flowers and 9 parts of schisandra chinensis.
The preparation method comprises the following steps: the medicines are mixed and decocted into decoction, 700mL of water is added into the first preparation to be decocted to 200mL, and mL of water is added into the second preparation to be decocted to 200mL.
The application method of the traditional Chinese medicine aromatherapy gel comprises the following steps: adding 0.1g of Chinese medicinal aromatherapy gel into 1L of water, performing aromatic fumigation once a day, 5min each time, and 7 days as a treatment course.
The use method of the oral decoction of the control group comprises the following steps: the medicine is taken twice a day, in the morning and at night, and 7 days are a treatment course.
The curative effect standard is as follows:
the effect is shown: the symptoms of rhinocnesmus, sneezing, rhinocnesmus and watery nasal discharge disappear;
the method has the following advantages: relieving or eliminating symptoms of rhinocnesmus, sneezing, rhinocnesmus and watery rhinorrhea;
and (4) invalidation: there was no change before and after treatment.
TABLE 1
| Show effect/human | Effective/human | Invalid/human | Total effective rate (%) | |
| Example 1 | 98 | 1 | 1 | 99 |
| Example 2 | 94 | 3 | 3 | 97 |
| Example 3 | 95 | 3 | 2 | 98 |
| Control group | 74 | 8 | 18 | 82 |
As can be seen from the table 1, the traditional Chinese medicine aromatherapy gel prepared by the invention has obvious effect on allergic rhinitis, short treatment period, quick response and convenient treatment, and avoids the pain and side effect caused by oral administration. And through observation after 2 months, only 3 patients treated by the traditional Chinese medicine aromatherapy gel have relapses, and 42 patients treated by the control group have relapses, which shows that the traditional Chinese medicine aromatherapy gel prepared by the invention has low relapse rate and good market prospect.
The above description is intended to be illustrative of the present invention and should not be taken as limiting the invention, as the invention is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.
Claims (5)
1. The traditional Chinese medicine composition for treating allergic rhinitis is characterized by being prepared from the following raw materials in parts by mass: 9 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 9 parts of biond magnolia flower, 5 parts of cocklebur fruit, 15 parts of mint, 15 parts of chrysanthemum, 9 parts of belvedere fruit and 9 parts of dark plum fruit;
the preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing raw materials by weight, cleaning, pulverizing to 80-100 mesh, mixing, and supercritical CO 2 Extracting volatile oil by extraction process to obtain orange crude oil, i.e. Chinese medicinal composition;
the pressure is 35-40MPa, the temperature is 40-50 ℃, and the flow is 40kg/h in the extraction process.
2. A traditional Chinese medicine aromatherapy gel, which is characterized by being prepared from the traditional Chinese medicine composition of claim 1.
3. The preparation method of the traditional Chinese medicine aromatherapy gel according to claim 2, characterized by comprising the following steps:
adding water into carrageenan, standing for 24h, adding the traditional Chinese medicine composition and laurocapram, heating the obtained mixture to boiling, cooling to 70 ℃, adding triethanolamine and potassium sorbate, stirring, cooling and solidifying to obtain the traditional Chinese medicine aromatherapy gel.
4. The preparation method according to claim 3, wherein the mass ratio of the traditional Chinese medicine composition to the carrageenan to the laurocapram is 1: (0.1-0.3): (0.08-0.1).
5. The method according to claim 3, wherein the triethanolamine is added in an amount of 0.2 to 0.4% by mass of the mixture, and the potassium sorbate is added in an amount of 0.1 to 0.3% by mass of the mixture.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085193A (en) * | 2006-06-09 | 2007-12-12 | 由春娜 | Method for preparing children indigestion-relieving gel |
| CN108837012A (en) * | 2018-09-26 | 2018-11-20 | 冯炜 | Chinese medicine composition and Yupingfeng anti-allergy preparation for allergic rhinitis |
| CN111759032A (en) * | 2020-04-16 | 2020-10-13 | 南京中医药大学 | Multifunctional protective mask and preparation method thereof |
| CN112156131A (en) * | 2020-11-10 | 2021-01-01 | 天津中医药大学 | Mask for treating rhinitis and preparation method |
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2021
- 2021-12-10 CN CN202111518913.9A patent/CN114259517B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085193A (en) * | 2006-06-09 | 2007-12-12 | 由春娜 | Method for preparing children indigestion-relieving gel |
| CN108837012A (en) * | 2018-09-26 | 2018-11-20 | 冯炜 | Chinese medicine composition and Yupingfeng anti-allergy preparation for allergic rhinitis |
| CN111759032A (en) * | 2020-04-16 | 2020-10-13 | 南京中医药大学 | Multifunctional protective mask and preparation method thereof |
| CN112156131A (en) * | 2020-11-10 | 2021-01-01 | 天津中医药大学 | Mask for treating rhinitis and preparation method |
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