CN101669995A - Composite for treatment and health care of heart cerebrovascular diseases and preparation method thereof - Google Patents
Composite for treatment and health care of heart cerebrovascular diseases and preparation method thereof Download PDFInfo
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- CN101669995A CN101669995A CN200910192665A CN200910192665A CN101669995A CN 101669995 A CN101669995 A CN 101669995A CN 200910192665 A CN200910192665 A CN 200910192665A CN 200910192665 A CN200910192665 A CN 200910192665A CN 101669995 A CN101669995 A CN 101669995A
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Abstract
The invention discloses a composite for treatment and health care of heart cerebrovascular diseases and a preparation method thereof; the composite comprises mucuna, fructus cannabis, salvia miltiorrhiza, schisandra chinensis, hydrangea aspera don and vermiculite. The composite can treat the heart cerebrovascular diseases safely, rapidly and effectively and be used for daily heart cerebrovascularhealth care, the adsorption is good, and the disadvantages that the adsorption rate of traditional Chinese medicines is low and the curative effect is slow in the prior art.
Description
Technical field
The present invention relates to a kind of compositions and preparation method that is used for cardiovascular and cerebrovascular diseases and health care.
Background technology
Cardiovascular and cerebrovascular disease is cardiovascular and cerebrovascular disease general designation.Cardiovascular and cerebrovascular disease is a kind of serious threat mankind, and particularly the commonly encountered diseases of middle-aged and elderly people health more than 50 years old even use most advanced, perfect at present treatment means, still can have the cerebrovascular accident survivor life more than 50% not take care of oneself fully! Every year is died from the number of cardiovascular and cerebrovascular disease up to 1,500 ten thousand people in the whole world, occupies various causes of the death first place.Cardiovascular and cerebrovascular disease has become the highest No.1 killer of the human dead cause of disease, also is " the noiseless demon " of health of people!
Cardiovascular and cerebrovascular disease has the characteristics of " sickness rate height, disability rate height, mortality rate height, relapse rate height, complication are how "-" four is high by more than one ", and at present, China cardiovascular and cerebrovascular disease patient has surpassed 2.7 hundred million people! China dies from nearly 3,000,000 people of cardiovascular and cerebrovascular disease every year, accounts for 51% of the annual total dead cause of disease of China.And the patient 75% who survives disability to some extent, 40% is heavy residual!
The medicine that is used for the treatment of cardiovascular and cerebrovascular disease at present has Western medicine that Chinese medicine is also arranged, Western medicine can be contained the state of an illness rapidly, effectively, but Western medicine is very serious to the side effects of human body, often make that the state of an illness is more serious, even stay some sequela or complication, and these diseases of treatment are to take for absorption of human body with the thick protein molecular structure form of Chinese herbal medicine decoction, Chinese patent medicine in the prior art, but are difficult to gather effect.
Polypeptide is a kind of nutrient substance that important biomolecule is learned function that has, the mechanism of absorption of polypeptide is better than all materials, therefore, the discovery of its mechanism of absorption, physiological health to the mankind is extremely important, the human mechanism of absorption that should utilize polypeptide is brought up to a brand-new level to human life and health, and this also is the place of the meaning of the great discovery of polypeptide mechanism of absorption.Regulate the different disease of human body with the physiological function of polypeptide, it will be the epoch-making revolution and the whole mankind's Gospel that human body is attained in health.
But at present, also do not have a kind of be used for cardiovascular and cerebrovascular diseases and health care peptide composition.
Summary of the invention
For solving the problem that prior art exists, the compositions that can be used for cardiovascular and cerebrovascular diseases and health care that the invention provides a kind of easy absorption, has no side effect.
The present invention is achieved in that
A kind of compositions that is used for cardiovascular and cerebrovascular diseases and health care, described compositions comprises MATENG, Fructus Cannabis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Folium hydrangeae strigosae and Hirudo.
Another object of the present invention provides a kind of described method for compositions that is used for cardiovascular and cerebrovascular diseases and health care for preparing, specifically:
(1) MATENG, Fructus Cannabis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Folium hydrangeae strigosae and Hirudo are cleaned up, broken then;
(2) step (1) gained mixture is carried out alcohol reflux, carry out multiple times of filtration after the end that refluxes;
(3) in filtrate, add concentrated sulphuric acid, reclaim the alcohol in the filtrate;
(4) filtrate of step (3) gained is carried out centrifugalize;
(5) the separating medium pH value after the centrifugalize is adjusted to 5.5～7.5, obtain being used for the total flavones bioactive substance of cardiovascular and cerebrovascular diseases and health care;
(6) with the purification of total flavones bioactive substance process, extraction, separation, the refining various polypeptide products that obtain flavonoid that extract.
MATENG is just widely plantation in ancient times, is used to cure the disease, and wine brewing, alcoholic intoxication, famine year allays one's hunger." Chinese medicine voluminous dictionary " carries: the MATENG root, and the tool heat-clearing and toxic substances removing, spasmolysis and analgesia, the yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal increases brain and coronary blood flow, improves effects such as brain microcirculation.Be used for the treatment of diseases such as hypertension, hyperlipidemia, coronary heart disease, angina pectoris, cerebral thrombosis, headache, dizziness, neck pain, sudden deafness, pneumonia clinically, evident in efficacy.And a large amount of Flavonoid substances that contain in the MATENG root also have cancer-resisting, enrich estrogen inducer and the plain pure effect of spring amount.
Fructus Cannabis is the dry mature seed of moraceae plants Fructus Cannabis, the Fructus Cannabis sweet in the mouth, and property is flat, return spleen, stomach, large intestine channel, the effect loosening bowel to relieve constipation, moisturize parasite killing, Fructus Cannabis contains very low cholesterol level, but and the plant sterol content 438mg/100g of very high cholesterol reducing.
The Radix Salviae Miltiorrhizae bitter in the mouth is slightly cold.GUIXIN, Liver Channel.Main effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Fructus Schisandrae Chinensis is warm in nature, and sour in the mouth, sweet is returned lung, the heart, kidney channel, and main curative effect is: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Hirudo is the general name of Annelida Hirudinea animal, is no vertebra Mollusca, and chassis less construction all can utilize.Main component is protein, polypeptide and trace element etc.Have removing blood stasis, removing blood stasis, function such as the painful abdominal mass of stimulating the menstrual flow, disappear; Hirudo is used to cure the disease, and long medicinal history is at home and abroad all arranged.China beginning remembers in Shennong's Herbal, later on each " Chinese pharmacopoeia is all on the books for the Compendium of Material Medica of medical science monograph such as Li Shizhen (1518-1593 A.D.) and modern each edition.Contain acid low molecular polypeptide in the Hirudo, molecular weight 4000～7000 has special effect; In the 17 contained seed amino acids, wherein 7 kinds is essential amino acid, and its content is the 1535mg/100g dry weight, accounts for 72% of whole aminoacid total quantitys, and these aminoacid play a part very important in the mankind's health care; Traditional drugs is used: blood stasis amenorrhea, traumatic injury; Modern medicinal: control diseases of cardiovascular and cerebrovascular systems such as apoplexy, hyperlipidemia etc. have wide range of applications.
The leaf of Folium hydrangeae strigosae, root, fruit all can be used as medicine, and the Folium hydrangeae strigosae nature and flavor are sweet, flat, nontoxic, and normal drink has nourishing liver and kidney, heat-clearing and toxic substances removing, antiinflammatory, the effect of promoting the production of body fluid for nourishing the lung, cough-relieving sore-throat relieving; Overweight people and suffer from the hyperpietic and drink has Weight-reducing and lipid-lowering, blood pressure lowering, reduction cholesterolemia, suppresses and delay sclerosis of blood vessels, prevent and treat coronary heart disease and arthritis effect, is the natural Chinese herbal medicines plant.Studies show that Folium hydrangeae strigosae contains 4.1% bioflavonoids, flavone is the good merchantable brand of the world the world of medicine control cardiovascular and cerebrovascular disease of generally acknowledging and the smelting cancer that gives protection against cancer; The Polyphenols that contains in the Folium hydrangeae strigosae is present optimal natural antioxidant simultaneously, has anti-fatigue, antidotal effect.The joint study of China Preventive Medicial Science Institute and Hebei Medical University shows that the effective percentage of its blood pressure lowering reaches 90.5%, obvious effective rate 80.6%.
The compositions that is used for cardiovascular and cerebrovascular diseases and health care provided by the invention is the biologically active peptide that utilizes modern biological new and high technology to obtain from natural medicine-food dual-use materials provided by the invention, be made into various health foods (as beverage, wine, food) or medicine, because pharmaceutical composition provided by the invention is to be lower than the special small material form of 10000 daltonian polypeptide with molecular weight to enter body for absorbing (being equivalent to nanometer food), thereby it is faster, safer, more effectively treat No.1 killer-cardiovascular and cerebrovascular disease (heart disease of current serious harm humans health, coronary heart disease, myocardial infarction, cerebral infarction, apoplexy, cerebral hemorrhage etc.), overcome in the prior art with Chinese herbal medicine decoction, the low difficult problem of absorbance that the thick protein molecular structure form of Chinese patent medicine or Western medicine is brought for absorption of human body, improved cure rate, also overcome Western medicine the deleterious shortcoming of the person.
The specific embodiment
Describe the present invention in detail below in conjunction with specific embodiment, be used for explaining the present invention in this illustrative examples of the present invention and explanation, but not as a limitation of the invention.
Embodiment 1:
The compositions that is used for cardiovascular and cerebrovascular diseases and health care that present embodiment provides comprises following components in part by weight:
15 parts of MATENG, 9 parts of Fructus Cannabiss, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Fructus Schisandrae Chinensis, 3 parts of Folium hydrangeae strigosae, 3 parts of Hirudo (polypeptide protein 50 ius).
The preparation of compositions method that present embodiment provides is:
(1) MATENG, Fructus Cannabis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Folium hydrangeae strigosae and Hirudo are cleaned up, broken then;
(2) step (1) gained mixture is carried out alcohol reflux, carry out multiple times of filtration after the end that refluxes;
(3) in filtrate, add concentrated sulphuric acid, reclaim the alcohol in the filtrate;
(4) filtrate of step (3) gained is carried out centrifugalize;
(5) the separating medium pH value after the centrifugalize is adjusted to 5.5～7.5, obtain being used for the total flavones bioactive substance of cardiovascular and cerebrovascular diseases and health care;
(6) with the purification of total flavones bioactive substance process, extraction, separation, the refining various polypeptide products that obtain flavonoid that extract.
Polypeptide had not both had the chemical toxicity side effect of Western medicine neither Western medicine neither Chinese medicine, did not have the bio-toxicity of similar indivedual Chinese medicines yet, and polypeptide is a kind of nutrient substance that important biomolecule is learned function that has.This Functional Polypeptides can not only provide the human body growth promoter required nutrient substance, and has special physiologic function: can blood fat reducing, slow down aging, body shaping skin care, antioxidation, anti-melancholy, resisting fatigue, improvement sleep, hypermnesis, inhibition tumor etc.; Can promote human body to protein, the absorption of vitamin and various healthy trace elements with household.
There is layer protecting film on polypeptide body self surface; can not be subjected to short enzyme, pepsin, pancreatin, amylase, digestive enzyme and the hydrolysis of acid-base material secondary of human body; it directly enters small intestinal with complete form and is absorbed, and brings into play its biological function with the human recycle system.The outer synthetic peptide composition of this prosthesis take enter human body speed as rocket, the scientist who has calls biological missile to it, pass people's oral cavity, stomach apace, directly entering small intestinal is absorbed, finally enter blood of human body blood circulation, organ and cell tissue, be absorbed by the body and utilize with complete form, bring into play its physiological action and biological function rapidly.It belongs to nutrition cures the disease, and is with " benefit ", cures the disease with " accent ", and the peptide nutrition that human body replenish to be lacked is cured the disease and strengthened healthy chain reaction with its physiological function.Polypeptide can play the transportation instrument in human body, the usual various nutrient substance of eating of people can be adsorbed on the peptide body, delivery is transported to each cell of human body, organ, tissue then, is absorbed by the body and utilizes together with body, brings into play different separately functions.
The compositions that is used for cardiovascular and cerebrovascular diseases and health care that present embodiment provides, MATENG, Fructus Cannabis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, the property of medicine synergism of Folium hydrangeae strigosae and each component of Hirudo, can treat cardiovascular and cerebrovascular disease (heart disease effectively, coronary heart disease, myocardial infarction, cerebral infarction, apoplexy, cerebral hemorrhage etc.), especially the peptide composition that adopts the present embodiment preparation method from above-mentioned substance, to extract, more can enter human body fast, be absorbed by the body, thereby fast, safety, treat cardiovascular and cerebrovascular disease effectively, overcome the shortcoming of Western medicine to the human injury, it is low also to have overcome existing Chinese medicine absorbance, the shortcoming that curative effect is slow.
The compositions that present embodiment provides can be made the form of medicine, as forms such as injection, tablet, capsule, powder, also can be made into the form of food, as beverage, wine, cookies, noodles, sugar etc., can also be made into the form of health product, as oral liquid, buccal tablet, chewable tablet etc., promptly can be made into different forms according to different user demands, select to take for people.
Embodiment 2:
The compositions that is used for cardiovascular and cerebrovascular diseases and health care that present embodiment provides comprises following components in part by weight:
30 parts of MATENG, 15 parts of Fructus Cannabiss, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Fructus Schisandrae Chinensis, 9 parts of Folium hydrangeae strigosae, 1.5 parts of Hirudo (polypeptide protein 20 ius).
Described preparation method is identical with embodiment 1 described method.
Embodiment 3:
The compositions that is used for cardiovascular and cerebrovascular diseases and health care that present embodiment provides comprises following components in part by weight:
20 parts of MATENG, 10 parts of Fructus Cannabiss, 12 parts of Radix Salviae Miltiorrhizaes, 4 parts of Fructus Schisandrae Chinensis, 6 parts of Folium hydrangeae strigosae, 2 parts of Hirudo (polypeptide protein 25 ius).
Described preparation method is identical with embodiment 1 described method.
More than the technical scheme that the embodiment of the invention provided is described in detail, used specific case herein the principle and the embodiment of the embodiment of the invention are set forth, the explanation of above embodiment only is applicable to the principle that helps to understand the embodiment of the invention; Simultaneously, for one of ordinary skill in the art, according to the embodiment of the invention, the part that on the specific embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.
Claims (6)
1, a kind of compositions that is used for cardiovascular and cerebrovascular diseases and health care, it is characterized in that: described compositions comprises MATENG, Fructus Cannabis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Folium hydrangeae strigosae and Hirudo.
2, the compositions that is used for cardiovascular and cerebrovascular diseases and health care as claimed in claim 1, it is characterized in that: described compositions comprises following components in part by weight:
15～30 parts of MATENG, 9～15 parts of Fructus Cannabiss, 9～15 parts of Radix Salviae Miltiorrhizaes, 2～6 parts of Fructus Schisandrae Chinensis, 3～9 parts of Folium hydrangeae strigosae, 1.5～3 parts of Hirudo.
3, the compositions that is used for cardiovascular and cerebrovascular diseases and health care as claimed in claim 2, it is characterized in that: described compositions comprises following components in part by weight:
15 parts of MATENG, 9 parts of Fructus Cannabiss, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Fructus Schisandrae Chinensis, 3 parts of Folium hydrangeae strigosae, 3 parts of Hirudo.
4, the compositions that is used for cardiovascular and cerebrovascular diseases and health care as claimed in claim 2, it is characterized in that: described compositions comprises following components in part by weight:
30 parts of MATENG, 15 parts of Fructus Cannabiss, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Fructus Schisandrae Chinensis, 9 parts of Folium hydrangeae strigosae, 1.5 parts of Hirudo.
5, the compositions that is used for cardiovascular and cerebrovascular diseases and health care as claimed in claim 2, it is characterized in that: described compositions comprises following components in part by weight:
20 parts of MATENG, 10 parts of Fructus Cannabiss, 12 parts of Radix Salviae Miltiorrhizaes, 4 parts of Fructus Schisandrae Chinensis, 6 parts of Folium hydrangeae strigosae, 2 parts of Hirudo.
6, a kind of preparation is as the described method for compositions that is used for cardiovascular and cerebrovascular diseases and health care of one of claim 1～5, and it is characterized in that: described method is:
(1) MATENG, Fructus Cannabis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Folium hydrangeae strigosae and Hirudo are cleaned up, broken then;
(2) step (1) gained mixture is carried out alcohol reflux, carry out multiple times of filtration after the end that refluxes;
(3) in filtrate, add concentrated sulphuric acid, reclaim the alcohol in the filtrate;
(4) filtrate of step (3) gained is carried out centrifugalize;
(5) the separating medium pH value after the centrifugalize is adjusted to 5.5～7.5, obtain being used for the total flavones bioactive substance of cardiovascular and cerebrovascular diseases and health care;
(6) with the purification of total flavones bioactive substance process, extraction, separation, the refining various polypeptide products that obtain flavonoid that extract.
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| CN200910192665A CN101669995A (en) | 2009-09-24 | 2009-09-24 | Composite for treatment and health care of heart cerebrovascular diseases and preparation method thereof |
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| CN200910192665A CN101669995A (en) | 2009-09-24 | 2009-09-24 | Composite for treatment and health care of heart cerebrovascular diseases and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102754886A (en) * | 2012-07-30 | 2012-10-31 | 黄祥泰 | Beverage and preparation method thereof, and applications of Taiwan benzoin leaves in preparation of beverage |
| EP3111780A1 (en) * | 2015-07-03 | 2017-01-04 | Analyticon Discovery GmbH | Natural stilbenes as sweeteners or sweetener enhancer |
| CN108669271A (en) * | 2018-05-26 | 2018-10-19 | 贵州江口骆象茶业有限公司 | A kind of elaeagnus conferta fruits health protection tea |
-
2009
- 2009-09-24 CN CN200910192665A patent/CN101669995A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102754886A (en) * | 2012-07-30 | 2012-10-31 | 黄祥泰 | Beverage and preparation method thereof, and applications of Taiwan benzoin leaves in preparation of beverage |
| CN102754886B (en) * | 2012-07-30 | 2013-06-12 | 黄祥泰 | Beverage and preparation method thereof, and applications of Taiwan benzoin leaves in preparation of beverage |
| EP3111780A1 (en) * | 2015-07-03 | 2017-01-04 | Analyticon Discovery GmbH | Natural stilbenes as sweeteners or sweetener enhancer |
| WO2017005515A1 (en) * | 2015-07-03 | 2017-01-12 | Analyticon Discovery Gmbh | Natural stilbenes as sweeteners or sweetener enhancer |
| AU2016290335B2 (en) * | 2015-07-03 | 2020-05-14 | Analyticon Discovery Gmbh | Natural stilbenes as sweeteners or sweetener enhancer |
| US10653172B2 (en) | 2015-07-03 | 2020-05-19 | Analyticon Discovery Gmbh | Natural stilbenes as sweeteners or sweetener enhancer |
| CN108669271A (en) * | 2018-05-26 | 2018-10-19 | 贵州江口骆象茶业有限公司 | A kind of elaeagnus conferta fruits health protection tea |
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Application publication date: 20100317 |